PKA, RI, PKA-RI, PKAr, cAMP-dependent protein kinase R1
Please see the JBrowse view of Dmel\Pka-R1 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Transposon inserted in intron 1
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.45
3.8, 3.4, 3.2, 2.7, 2.4 (northern blot)
The group(s) of polypeptides indicated below share identical sequence to each other.
377, 320, 297 (aa)
class IV gene
class II gene
class I gene
class III gene
Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer.
The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain but is not phosphorylated. The physiological significance of phosphorylations by other kinases is unclear.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pka-R1 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
JBrowse - Visual display of RNA-Seq signals
View Dmel\Pka-R1 in JBrowse
3-47
3-43.7
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Gene expression is increased in response to the presence of two copies of Scer\GAL4hs.PB.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Molecular, genetic, biochemical and behavioural characterisation of Pka-R1 mutants.
Isolated from a genomic DNA library using a bovine cDNA probe for a type I regulatory subunit of cAMP-dependent protein kinase.
Pka-R1 encodes a type I regulatory subunit of the cAMP-dependent protein kinase.
Mst77F is encoded by the first intron of Pka-R1, and is transcribed off the opposite strand.
Encodes the type I regulatory subunit form of Pka. Gene is expressed particularly abundantly in mushroom bodies.
P-element insertions near transcription start sites are homozygous viable but have decreased ability to learn in a classical olfactory conditioning paradigm (FBrf0058270).
Source for merge of: Pka-R1 l(3)18304
Source for merge of: Pka-R1 CG12452
Annotations CG3263 and CG12452 merged as CG42341 in release 5.9 of the genome annotation.
Release 1 annotation CG18677 corresponds to part of release 3.2 annotation CG3263 (Pka-R1).
