The gene bruchpilot is referred to in FlyBase by the symbol Dmel\brp (CG42344, FBgn0259246). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: calcium channel activity. There is experimental evidence that it is involved in the biological process: synaptic transmission; neuromuscular synaptic transmission; regulation of synaptic plasticity; neurotransmitter secretion; adult locomotory behavior; cytoskeletal matrix organization at active zone; maintenance of presynaptic active zone structure; short-term memory; anesthesia-resistant memory. 36 alleles are reported. The phenotypes of these alleles are annotated with: t-bar; neuromuscular junction; embryonic/larval neuromuscular junction; mesothoracic tergum; synapse; synaptic vesicle. It has 9 annotated transcripts and 9 annotated polypeptides. Protein features are: CAZ complex, RIM-binding protein. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: adult brain. Gene sequence location is 2R:5391270..5428822.
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In lamina cross section, expression of brp is largely restricted to the ring of R1-R6 terminals within the photoreceptor cartridge, and shows a punctate distribution. Using immunoelectron microscopy, immunosignals are localized to regions of the T-bar ribbon in photoreceptor tetrads, specifically at the edge of the ribbon's platform. It is also expressed in the neuropils of the central brain.
brp protein is expressed in larva and adults as discrete puncta in the presynatic active zone of the mushroom body alpha/beta, alpha'/beta' and gamma neurons and calyx.
brp protein labels the presynaptic terminals in the medulla and lamina. Co-expression of brp and Scer\GAL4cry.PE labelled cell projections was observed in the medulla, corresponding to DN3 neurons, but not in the lamina.
brp protein is expressed in the presynaptic active zone. In the larval neuromuscular junction, it defines the core of the active zone, being surrounded by clusters of Liprin-α and RhoGAP100F.
Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: adult brain.
[download data (TSV)]
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, during late pupal stages.
[download data (TSV)]
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cDNA Clones ( 54 )
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cDNAs and ESTs that fall within the genomic extent
of the gene model, which may include cDNAs and ESTs
of genes within introns, or of overlapping genes.
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brp mutant neuromuscular synapses suffer from active zone membrane defects, a complete loss of presynaptic dense bodies and severely depressed evoked vesicle release. Presynaptic Ca2+-channels become diffusely distributed in brp mutants.
Nicotinamide mononucleotide adenylyltransferase maintains active zone structure by stabilizing Bruchpilot. [FBrf0220367]
Beck et al., 2012, J. Neurosci. 32(20): 7058--7073
Regulation of Fasciclin II and Synaptic Terminal Development by the Splicing Factor Beag. [FBrf0218385]
Bousquet et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(1): 249--254
Expression of a desaturase gene, desat1, in neural and nonneural tissues separately affects perception and emission of sex pheromones in Drosophila. [FBrf0217137]
Bruckner et al., 2012, J. Neurosci. 32(48): 17048--17058
Fife, a Drosophila Piccolo-RIM Homolog, Promotes Active Zone Organization and Neurotransmitter Release. [FBrf0220079]
Chen and Ganetzky, 2012, J. Cell Biol. 196(4): 529--543
A neuropeptide signaling pathway regulates synaptic growth in Drosophila. [FBrf0217500]
de Vries and Clandinin, 2012, Curr. Biol. 22(5): 353--362
Loom-sensitive neurons link computation to action in the Drosophila visual system. [FBrf0217719]
Dickman et al., 2012, J. Neurosci. 32(25): 8716--8724
Snapin is Critical for Presynaptic Homeostatic Plasticity. [FBrf0218676]
Füger et al., 2012, PLoS Genet. 8(11): e1003066
Spastic Paraplegia Mutation N256S in the Neuronal Microtubule Motor KIF5A Disrupts Axonal Transport in a Drosophila HSP Model. [FBrf0220146]
Graf et al., 2012, J. Neurosci. 32(47): 16586--16596
RIM Promotes Calcium Channel Accumulation at Active Zones of the Drosophila Neuromuscular Junction. [FBrf0220028]
Hergarden et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(10): 3967--3972
Allatostatin-A neurons inhibit feeding behavior in adult Drosophila. [FBrf0217661]
Jafari et al., 2012, PLoS Biol. 10(3): e1001280
Combinatorial activation and repression by seven transcription factors specify Drosophila odorant receptor expression. [FBrf0217822]
Jordán-Álvarez et al., 2012, J. Cell Sci. 125(15): 3621--3629
Presynaptic PI3K activity triggers the formation of glutamate receptors at neuromuscular terminals of Drosophila. [FBrf0219610]
Kahsai et al., 2012, Neuroscience 208: 11--26
Distribution of metabotropic receptors of serotonin, dopamine, GABA, glutamate, and short neuropeptide F in the central complex of Drosophila. [FBrf0217851]
Keleman et al., 2012, Nature 489(7414): 145--149
Dopamine neurons modulate pheromone responses in Drosophila courtship learning. [FBrf0219398]
Kim and Marqués, 2012, Dev. Neurobiol. 72(12): 1541--1558
The Ly6 neurotoxin-like molecule target of wit regulates spontaneous neurotransmitter release at the developing neuromuscular junction in Drosophila. [FBrf0219871]
Kim et al., 2012, Genes Dev. 26(9): 974--987
Drosophila Neto is essential for clustering glutamate receptors at the neuromuscular junction. [FBrf0218161]
Koles et al., 2012, J. Biol. Chem. 287(20): 16820--16834
Mechanism of evenness interrupted (evi)-exosome release at synaptic boutons. [FBrf0218323]
Krauchunas et al., 2012, Dev. Biol. 370(1): 125--134
Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. [FBrf0219342]
Krüttner et al., 2012, Neuron 76(2): 383--395
Drosophila CPEB Orb2A Mediates Memory Independent of Its RNA-Binding Domain. [FBrf0219767]
Lloyd et al., 2012, Neuron 74(2): 344--360
The p150(Glued) CAP-Gly Domain Regulates Initiation of Retrograde Transport at Synaptic Termini. [FBrf0218160]
Lutas et al., 2012, G3 (Bethesda) 2(1): 59--69
Genetic analysis in Drosophila reveals a role for the mitochondrial protein p32 in synaptic transmission. [FBrf0217628]
Masuyama et al., 2012, J. Neurogenet. 26(1): 89--102
Mapping neural circuits with activity-dependent nuclear import of a transcription factor. [FBrf0217864]
Miller et al., 2012, J. Neurosci. 32(40): 13776--13786
Analysis of synaptic growth and function in Drosophila with an extended larval stage. [FBrf0219554]
Mosca et al., 2012, Nature 484(7393): 237--241
Trans-synaptic Teneurin signalling in neuromuscular synapse organization and target choice. [FBrf0218053]
Nechipurenko and Broihier, 2012, J. Cell Biol. 196(3): 345--362
FoxO limits microtubule stability and is itself negatively regulated by microtubule disruption. [FBrf0217391]
Nfonsam et al., 2012, PLoS ONE 7(8): e44583
Analysis of the Transcriptomes Downstream of Eyeless and the Hedgehog, Decapentaplegic and Notch Signaling Pathways in Drosophila melanogaster. [FBrf0219414]
Owald et al., 2012, Nat. Neurosci. 15(9): 1219--1226
Cooperation of Syd-1 with Neurexin synchronizes pre- with postsynaptic assembly. [FBrf0219330]
Penney et al., 2012, Neuron 74(1): 166--178
TOR Is Required for the Retrograde Regulation of Synaptic Homeostasis at the Drosophila Neuromuscular Junction. [FBrf0218076]
Prieto-Godino et al., 2012, PLoS Biol. 10(10): e1001400
Embryonic origin of olfactory circuitry in Drosophila: contact and activity-mediated interactions pattern connectivity in the antennal lobe. [FBrf0219665]
Knockdown of the Drosophila Fused in Sarcoma (FUS) Homologue Causes Deficient Locomotive Behavior and Shortening of Motoneuron Terminal Branches. [FBrf0218682]
Shohat-Ophir et al., 2012, Science 335(6074): 1351--1355
Sexual deprivation increases ethanol intake in Drosophila. [FBrf0217810]
Starostina et al., 2012, J. Neurosci. 32(13): 4665--4674
A Drosophila DEG/ENaC Subunit Functions Specifically in Gustatory Neurons Required for Male Courtship Behavior. [FBrf0217925]
Stephan et al., 2012, J. Neurosci. 32(46): 16080--16094
Drosophila Psidin Regulates Olfactory Neuron Number and Axon Targeting through Two Distinct Molecular Mechanisms. [FBrf0220017]
Tayler et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(50): 20697--20702
A neuropeptide circuit that coordinates sperm transfer and copulation duration in Drosophila. [FBrf0220217]
Tsai et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(43): 17699--17704
Activity-dependent retrograde laminin A signaling regulates synapse growth at Drosophila neuromuscular junctions. [FBrf0219768]
Weber et al., 2012, PLoS ONE 7(4): e34745
Genome-Wide Association Analysis of Oxidative Stress Resistance in Drosophila melanogaster. [FBrf0218073]
Zhou et al., 2012, J. Neurosci. 32(41): 14281--14287
Molecular Genetic Analysis of Sexual Rejection: Roles of Octopamine and Its Receptor OAMB in Drosophila Courtship Conditioning. [FBrf0219612]
Abou Tayoun et al., 2011, J. Neurosci. 31(39): 13897--13910
The Drosophila SK Channel (dSK) Contributes to Photoreceptor Performance by Mediating Sensitivity Control at the First Visual Network. [FBrf0216279]
Baas et al., 2011, Development 138(3): 553--563
Sugar-free frosting, a homolog of SAD kinase, drives neural-specific glycan expression in the Drosophila embryo. [FBrf0212690]
Besson et al., 2011, J. Comp. Neurol. 519(14): 2734--2757
Involvement of the drosophila taurine/aspartate transporter dEAAT2 in selective olfactory and gustatory perceptions. [FBrf0214574]
Chen et al., 2011, PLoS ONE 6(4): e18853
Highly Tissue Specific Expression of Sphinx Supports Its Male Courtship Related Role in Drosophila melanogaster. [FBrf0213606]
Cheng et al., 2011, J. Cell Biol. 194(6): 921--935
S6 kinase localizes to the presynaptic active zone and functions with PDK1 to control synapse development. [FBrf0216911]
Christiansen et al., 2011, J. Neurosci. 31(26): 9696--9707
Presynapses in Kenyon Cell Dendrites in the Mushroom Body Calyx of Drosophila. [FBrf0214059]
Cognigni et al., 2011, Cell Metab. 13(1): 92--104
Enteric neurons and systemic signals couple nutritional and reproductive status with intestinal homeostasis. [FBrf0212594]
Damulewicz and Pyza, 2011, PLoS ONE 6(6): e21258
The Clock Input to the First Optic Neuropil of Drosophila melanogaster Expressing Neuronal Circadian Plasticity. [FBrf0214354]
Glial-derived prodegenerative signaling in the Drosophila neuromuscular system. [FBrf0216904]
King et al., 2011, J. Neurosci. 31(3): 1139--1148
Drosophila tao Controls Mushroom Body Development and Ethanol-Stimulated Behavior through par-1. [FBrf0212818]
Knapek et al., 2011, J. Neurosci. 31(9): 3453--3458
Bruchpilot, a synaptic active zone protein for anesthesia-resistant memory. [FBrf0213189]
Koon et al., 2011, Nat. Neurosci. 14(2): 190--199
Autoregulatory and paracrine control of synaptic and behavioral plasticity by octopaminergic signaling. [FBrf0212895]
Lieber et al., 2011, Neuron 69(3): 468--481
DSL-Notch Signaling in the Drosophila Brain in Response to Olfactory Stimulation. [FBrf0212999]
Liu et al., 2011, J. Neurosci. 31(6): 2052--2063
Drosophila Acyl-CoA Synthetase Long-Chain Family Member 4 Regulates Axonal Transport of Synaptic Vesicles and Is Required for Synaptic Development and Transmission. [FBrf0212968]
Liu et al., 2011, Science 334(6062): 1565--1569
RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release. [FBrf0216992]
Miśkiewicz et al., 2011, Neuron 72(5): 776--788
ELP3 Controls Active Zone Morphology by Acetylating the ELKS Family Member Bruchpilot. [FBrf0216903]
Morante et al., 2011, Development 138(4): 687--693
Cell migration in Drosophila optic lobe neurons is controlled by eyeless/Pax6. [FBrf0212874]
Müller et al., 2011, Neuron 69(4): 749--762
Rab3-GAP Controls the Progression of Synaptic Homeostasis at a Late Stage of Vesicle Release. [FBrf0213055]
Pak et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(30): 12390--12395
Mutation of the conserved polyadenosine RNA binding protein, ZC3H14/dNab2, impairs neural function in Drosophila and humans. [FBrf0214553]
Peled and Isacoff, 2011, Nat. Neurosci. 14(4): 519--526
Optical quantal analysis of synaptic transmission in wild-type and rab3-mutant Drosophila motor axons. [FBrf0213336]
Pilgram et al., 2011, J. Neurosci. 31(2): 492--500
The RhoGAP crossveinless-c Interacts with Dystrophin and Is Required for Synaptic Homeostasis at the Drosophila Neuromuscular Junction. [FBrf0212767]
Pitman et al., 2011, Curr. Biol. 21(10): 855--861
A pair of inhibitory neurons are required to sustain labile memory in the Drosophila mushroom body. [FBrf0213725]
Rossetto et al., 2011, Hum. Mol. Genet. 20(21): 4248--4257
Defhc1.1, a homologue of the juvenile myoclonic gene EFHC1, modulates architecture and basal activity of the neuromuscular junction in Drosophila. [FBrf0216330]
Sarthi and Elefant, 2011, PLoS ONE 6(10): e26202
dTip60 HAT Activity Controls Synaptic Bouton Expansion at the Drosophila Neuromuscular Junction. [FBrf0216592]
Shakiryanova et al., 2011, J. Neurosci. 31(25): 9093--9100
Differential Control of Presynaptic CaMKII Activation and Translocation to Active Zones. [FBrf0213996]
Sprecher et al., 2011, Dev. Biol. 358(1): 33--43
The Drosophila larval visual system: High-resolution analysis of a simple visual neuropil. [FBrf0215208]
Sun et al., 2011, J. Neurosci. 31(2): 687--699
Neuroligin 2 is required for synapse development and function at the Drosophila neuromuscular junction. [FBrf0212770]
Sweeney et al., 2011, Neuron 72(5): 734--747
Secreted Semaphorins from Degenerating Larval ORN Axons Direct Adult Projection Neuron Dendrite Targeting. [FBrf0216932]
Vrailas-Mortimer et al., 2011, Dev. Cell 21(4): 783--795
A Muscle-Specific p38 MAPK/Mef2/MnSOD Pathway Regulates Stress, Motor Function, and Life Span in Drosophila. [FBrf0216446]
Weyhersmüller et al., 2011, J. Neurosci. 31(16): 6041--6052
Rapid Active Zone Remodeling during Synaptic Plasticity. [FBrf0213525]
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