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Gene Dmel\brp

General Information
Symbol	Dmel\brp	Species	D. melanogaster
Name	bruchpilot	Annotation symbol	CG42344
Feature type	protein_coding_gene	FlyBase ID	FBgn0259246
Gene Model Status	Current	Stock availability	20 publicly available
Also Known As	nc82, CG30337, CG34146, mAb nc82, MAbnc82, CG12932
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	45E3-45F1	Sequence location	2R:5,391,293..5,428,822 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene bruchpilot is referred to in FlyBase by the symbol Dmel\brp (CG42344, FBgn0259246). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: calcium channel activity. There is experimental evidence that it is involved in the biological process: synaptic transmission; neuromuscular synaptic transmission; regulation of synaptic plasticity; neurotransmitter secretion; adult locomotory behavior; maintenance of presynaptic active zone structure; short-term memory; anesthesia-resistant memory. 27 alleles are reported. The phenotypes of these alleles are annotated with: t-bar; embryonic/larval neuromuscular junction; mesothoracic tergum. It has 9 annotated transcripts and 9 annotated polypeptides. Protein features are: CAZ complex, RIM-binding protein. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: adult brain. Gene sequence location is 2R:5391293..5428822.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Clones 38417 62581 HL04211 EK121854 EK137237 9690 EK103627 73071 161717 74926 29418 RH42027 EK248442 EK266019 EK188539 39287 166532 EK269635 EK156263 RH59150 EK121851 121275 EK204964 174733 CK01.170A.D1 EK302207 EK151618 165128 145925 EK063904
FB2012_01	Transgenic Constructs P{UAS-brp-short[mCherry]} Alleles brp[MI02987] brp[S.Scer\UAS.T:Disc\RFP-mCherry] References Vrailas-Mortimer et al., 2011, Dev. Cell 21(4): 783--795 Hallermann et al., 2010, J. Neurosci. 30(43): 14340--14345 Albornoz et al., 2008, Gene Expr. Patterns 8(6): 443--451 Bellen, 2011.10.25, set956.xml Carlsson et al., 2010, J. Comp. Neurol. 518(16): 3359--3380 Knight et al., 2010, J. Neurosci. 30(14): 5047--5057 Kuromi et al., 2010, Europ. J. Neurosci. 32(3): 335--346 Rohrbough and Broadie, 2010, Development 137(20): 3523--3533 Rossetto et al., 2011, Hum. Mol. Genet. 20(21): 4248--4257 Sequence features BKN28677 HFA06245 HFA06801 HFA06246 BKN29701 BKN29577 BKN31455 Insertions Mi{MIC}brp[MI02987]
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 45E3-45F1   Limits computationally determined from genome sequence between P{lacW}wunk09507&P{lacW}l(2)k12402k12402 and P{EP}EP2165&P{lacW}l(2)k01301k01301
Experimentally Determined Cytological Location
Cytogenetic map Notes References 45E4-45E4   Limits computationally determined from genome sequence between P{lacW}wunk09507&P{lacW}l(2)k12402k12402 and P{EP}EP2165&P{lacW}l(2)k01301k01301;   (Buchner, 2004.10.12)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\brp for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.42 Gene merge based on EST/cDNA data. Due to an oversight in the implementation of gene annotation merges, one of the transcripts (and the corresponding polypeptide) of this gene were assigned non-unique symbols in r5.9. Although there were no conflicts within a given release, the same symbols were used for different isoforms in different releases. The affected gene product symbols have now been changed to symbols not used previously in the database; see individual transcript reports for details.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) brp-RD FBtr0299915  NM_165677   9656   1740 brp-RE FBtr0299916  NM_206063   6049   1740 brp-RF FBtr0299917  NM_136649   3421   750 brp-RG FBtr0300245  NM_001103771   9412   1786 brp-RH FBtr0300542  NM_001043070   5562   1740 brp-RI FBtr0305059     4811   1397 brp-RJ FBtr0305060     11638   2238 brp-RK FBtr0305061     6203   1707 brp-RL FBtr0305062     6425   1781
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein brp-PD   FBpp0289193   201.7   1740   6.13     NP_724796   AAM71068 brp-PE   FBpp0289194   201.7   1740   6.13     NP_995785   AAS64886 brp-PF   FBpp0289195   83.3   750   8.55     NP_610493   AAF58931 brp-PG   FBpp0289478   206.7   1786   6.25     NP_001097241   ABV53738 brp-PH   FBpp0289769   201.7   1740   6.13     NP_001036535   AAF58930 brp-PI   FBpp0293596   161.7   1397   5.80       brp-PJ   FBpp0293597   255.3   2238   6.90       brp-PK   FBpp0293598   197.4   1707   6.27       brp-PL   FBpp0293599   206.2   1781   6.24
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • CAZ complex, RIM-binding protein (IPR019323)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA697442   AA698283   AE013599 AAF58930   AE013599 AAF58931   AE013599 AAM71068   AE013599 AAS64886   AE013599 ABV53738   AJ849544 CAH61079   AY119446 AAM50100   BF490099   BF495753   BF505532   BI612987   BI630166   BT025916   BT029931   BT058052   CO185381   CO185453   CO264038   CO267727   CO271490   CO276698   CO276701   CO281248   CO286797   CO293854   CO299026   CO305392   CO316834   CO317891   CO322636   CO328519   CO331971   CO344807   EC077997   EC078253   EC080106   EC082879   EC088809   EC197635   EC199210   EC200574   EC204217   EC210645   EC212540   EC217284   EC220747   EC227387   EC237648   EC244228   EC247255   EC252452   EC255144   EC258569   EC259953   EL879235   EL879236   EL879345   EL879734   EL882163   EL882164   ES690947
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8MRS3 Q25B55 A1Z7V1 A1Z7V2 A8DY79
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 16 -- 17   embryonic/larval neuromuscular junction   (Banovic et al., 2010) third instar larval stage   embryonic/larval neuromuscular junction   • presynaptic active zone (Marrus and DiAntonio, 2004) synapse   • presynaptic active zone (Graf et al., 2009) adult stage   adult antennal lobe glomerulus   (Laissue et al., 1999) lamina neuropil | restricted   (Hamanaka and Meinertzhagen, 2010) medulla neuropil | restricted   (Hamanaka and Meinertzhagen, 2010) photoreceptor cell R1 | restricted   (Hamanaka and Meinertzhagen, 2010) photoreceptor cell R2 | restricted   (Hamanaka and Meinertzhagen, 2010) photoreceptor cell R3 | restricted   (Hamanaka and Meinertzhagen, 2010) photoreceptor cell R4 | restricted   (Hamanaka and Meinertzhagen, 2010) photoreceptor cell R5 | restricted   (Hamanaka and Meinertzhagen, 2010) photoreceptor cell R6 | restricted   (Hamanaka and Meinertzhagen, 2010)
Additional Descriptive Data
	In lamina cross section, expression of brp is largely restricted to the ring of R1-R6 terminals within the photoreceptor cartridge, and shows a punctate distribution. Using immunoelectron microscopy, immunosignals are localized to regions of the T-bar ribbon in photoreceptor tetrads, specifically at the edge of the ribbon's platform. It is also expressed in the neuropils of the central brain. (Hamanaka and Meinertzhagen, 2010) nc82 is used as a generic marker for neuropil structures. (Laissue et al., 1999) brp localizes opposite to clusters of glutamate receptors in the neuromuscular junction of late-stage embryos. (Banovic et al., 2010)
Marker for
	neuropil
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0259246    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0259246 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0259246 expression level Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    15 embryo 04-06hr    17 embryo 06-08hr    31 embryo 08-10hr    32 embryo 10-12hr    70 embryo 12-14hr    280 embryo 14-16hr    1264 embryo 16-18hr    1746 embryo 18-20hr    2469 embryo 20-22hr    1821 embryo 22-24hr    1523 larva L1    1679 larva L2    549 larva L3 12hr old    180 larva L3 puffstage 1-2    74 larva L3 puffstage 3-6    288 larva L3 puffstage 7-9    299 white prepupae new    325 white prepupae 12hr    791 white prepupae 24hr    1191 pupae 2d postWPP    1666 pupae 3d postWPP    1306 pupae 4d postWPP    610 adult male 01day    796 adult male 05day    894 adult male 30day    743 adult female 01day    363 adult female 05day    82 adult female 30day    101 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    15 embryo 04-06hr    17 embryo 06-08hr    31 embryo 08-10hr    32 embryo 10-12hr    70 embryo 12-14hr  (280) embryo 14-16hr  (1264) embryo 16-18hr  (1746) embryo 18-20hr  (2469) embryo 20-22hr  (1821) embryo 22-24hr  (1523) larva L1  (1679) larva L2  (549) larva L3 12hr old  (180) larva L3 puffstage 1-2    74 larva L3 puffstage 3-6  (288) larva L3 puffstage 7-9  (299) white prepupae new  (325) white prepupae 12hr  (791) white prepupae 24hr  (1191) pupae 2d postWPP  (1666) pupae 3d postWPP  (1306) pupae 4d postWPP  (610) adult male 01day  (796) adult male 05day  (894) adult male 30day  (743) adult female 01day  (363) adult female 05day    82 adult female 30day  101 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    15 embryo 04-06hr    17 embryo 06-08hr    31 embryo 08-10hr    32 embryo 10-12hr    70 embryo 12-14hr    280 embryo 14-16hr    1264 embryo 16-18hr  (1746) embryo 18-20hr  (2469) embryo 20-22hr  (1821) embryo 22-24hr  (1523) larva L1  (1679) larva L2    549 larva L3 12hr old    180 larva L3 puffstage 1-2    74 larva L3 puffstage 3-6    288 larva L3 puffstage 7-9    299 white prepupae new    325 white prepupae 12hr    791 white prepupae 24hr    1191 pupae 2d postWPP  (1666) pupae 3d postWPP    1306 pupae 4d postWPP    610 adult male 01day    796 adult male 05day    894 adult male 30day    743 adult female 01day    363 adult female 05day    82 adult female 30day    101 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    15 embryo 04-06hr    17 embryo 06-08hr    31 embryo 08-10hr    32 embryo 10-12hr    70 embryo 12-14hr    280 embryo 14-16hr    1264 embryo 16-18hr    1746 embryo 18-20hr    2469 embryo 20-22hr    1821 embryo 22-24hr    1523 larva L1    1679 larva L2    549 larva L3 12hr old    180 larva L3 puffstage 1-2    74 larva L3 puffstage 3-6    288 larva L3 puffstage 7-9    299 white prepupae new    325 white prepupae 12hr    791 white prepupae 24hr    1191 pupae 2d postWPP    1666 pupae 3d postWPP    1306 pupae 4d postWPP    610 adult male 01day    796 adult male 05day    894 adult male 30day    743 adult female 01day    363 adult female 05day    82 adult female 30day    101 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    15 embryo 04-06hr    17 embryo 06-08hr    31 embryo 08-10hr    32 embryo 10-12hr    70 embryo 12-14hr    280 embryo 14-16hr    1264 embryo 16-18hr    1746 embryo 18-20hr    2469 embryo 20-22hr    1821 embryo 22-24hr    1523 larva L1    1679 larva L2    549 larva L3 12hr old    180 larva L3 puffstage 1-2    74 larva L3 puffstage 3-6    288 larva L3 puffstage 7-9    299 white prepupae new    325 white prepupae 12hr    791 white prepupae 24hr    1191 pupae 2d postWPP    1666 pupae 3d postWPP    1306 pupae 4d postWPP    610 adult male 01day    796 adult male 05day    894 adult male 30day    743 adult female 01day    363 adult female 05day    82 adult female 30day    101 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0259246 expression level Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    15 embryo 04-06hr    17 embryo 06-08hr    31 embryo 08-10hr    32 embryo 10-12hr    70 embryo 12-14hr    280 embryo 14-16hr    1264 embryo 16-18hr    1746 embryo 18-20hr    2469 embryo 20-22hr    1821 embryo 22-24hr    1523 larva L1    1679 larva L2    549 larva L3 12hr old    180 larva L3 puffstage 1-2    74 larva L3 puffstage 3-6    288 larva L3 puffstage 7-9    299 white prepupae new    325 white prepupae 12hr    791 white prepupae 24hr    1191 pupae 2d postWPP    1666 pupae 3d postWPP    1306 pupae 4d postWPP    610 adult male 01day    796 adult male 05day    894 adult male 30day    743 adult female 01day    363 adult female 05day    82 adult female 30day    101 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    15 embryo 04-06hr    17 embryo 06-08hr    31 embryo 08-10hr    32 embryo 10-12hr    70 embryo 12-14hr  (280) embryo 14-16hr  (1264) embryo 16-18hr  (1746) embryo 18-20hr  (2469) embryo 20-22hr  (1821) embryo 22-24hr  (1523) larva L1  (1679) larva L2  (549) larva L3 12hr old  (180) larva L3 puffstage 1-2    74 larva L3 puffstage 3-6  (288) larva L3 puffstage 7-9  (299) white prepupae new  (325) white prepupae 12hr  (791) white prepupae 24hr  (1191) pupae 2d postWPP  (1666) pupae 3d postWPP  (1306) pupae 4d postWPP  (610) adult male 01day  (796) adult male 05day  (894) adult male 30day  (743) adult female 01day  (363) adult female 05day    82 adult female 30day  101 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    15 embryo 04-06hr    17 embryo 06-08hr    31 embryo 08-10hr    32 embryo 10-12hr    70 embryo 12-14hr    280 embryo 14-16hr    1264 embryo 16-18hr  1746 embryo 18-20hr  2469 embryo 20-22hr  1821 embryo 22-24hr  1523 larva L1  1679 larva L2    549 larva L3 12hr old    180 larva L3 puffstage 1-2    74 larva L3 puffstage 3-6    288 larva L3 puffstage 7-9    299 white prepupae new    325 white prepupae 12hr    791 white prepupae 24hr    1191 pupae 2d postWPP  1666 pupae 3d postWPP    1306 pupae 4d postWPP    610 adult male 01day    796 adult male 05day    894 adult male 30day    743 adult female 01day    363 adult female 05day    82 adult female 30day    101 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    15 embryo 04-06hr    17 embryo 06-08hr    31 embryo 08-10hr    32 embryo 10-12hr    70 embryo 12-14hr    280 embryo 14-16hr    1264 embryo 16-18hr    1746 embryo 18-20hr    2469 embryo 20-22hr    1821 embryo 22-24hr    1523 larva L1    1679 larva L2    549 larva L3 12hr old    180 larva L3 puffstage 1-2    74 larva L3 puffstage 3-6    288 larva L3 puffstage 7-9    299 white prepupae new    325 white prepupae 12hr    791 white prepupae 24hr    1191 pupae 2d postWPP    1666 pupae 3d postWPP    1306 pupae 4d postWPP    610 adult male 01day    796 adult male 05day    894 adult male 30day    743 adult female 01day    363 adult female 05day    82 adult female 30day    101 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    15 embryo 04-06hr    17 embryo 06-08hr    31 embryo 08-10hr    32 embryo 10-12hr    70 embryo 12-14hr    280 embryo 14-16hr    1264 embryo 16-18hr    1746 embryo 18-20hr    2469 embryo 20-22hr    1821 embryo 22-24hr    1523 larva L1    1679 larva L2    549 larva L3 12hr old    180 larva L3 puffstage 1-2    74 larva L3 puffstage 3-6    288 larva L3 puffstage 7-9    299 white prepupae new    325 white prepupae 12hr    791 white prepupae 24hr    1191 pupae 2d postWPP    1666 pupae 3d postWPP    1306 pupae 4d postWPP    610 adult male 01day    796 adult male 05day    894 adult male 30day    743 adult female 01day    363 adult female 05day    82 adult female 30day    101 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0259246    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0259246 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: adult brain. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis no informative data Adult Male Accessory Gland     Adult Carcass     modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_14
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259246 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12932-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | larval stage (with Df(2R)BSC29) brp69 viable, with Scer\GAL4elav-C155 brpdsRNA.C.Scer\UAS viable, with Scer\GAL4GMR.PF brpdsRNA.C.Scer\UAS viable, with Scer\GAL4pnr-MD237 brpGD7874 brpGD10046 Other Phenotypes Allele body color defective, with Scer\GAL4pnr-MD237 brpGD10046 flight defective, with Scer\GAL4elav-C155 brpdsRNA.C.Scer\UAS locomotor behavior defective, with Scer\GAL4elav-C155 brpdsRNA.B.Scer\UAS brpdsRNA.C.Scer\UAS memory defective, with Scer\GAL4c739, brpdsRNA.B.Scer\UAS brpdsRNA.C.Scer\UAS memory defective, with Scer\GAL4c739, brpdsRNA.C.Scer\UAS brpdsRNA.B.Scer\UAS memory defective, with Scer\GAL4ey-OK107, brpdsRNA.B.Scer\UAS brpdsRNA.C.Scer\UAS memory defective, with Scer\GAL4ey-OK107, brpdsRNA.C.Scer\UAS brpdsRNA.B.Scer\UAS memory defective, with Scer\GAL4Mef2.247, brpdsRNA.B.Scer\UAS brpdsRNA.C.Scer\UAS memory defective, with Scer\GAL4Mef2.247, brpdsRNA.C.Scer\UAS brpdsRNA.B.Scer\UAS neuroanatomy defective (with Df(2R)BSC29) brp69 neurophysiology defective, with Scer\GAL4BG380 brpScer\UAS.T:Avic\GFP neurophysiology defective, with Scer\GAL4elav.Switch.PO brpScer\UAS.T:Avic\GFP neurophysiology defective, with Scer\GAL4elav-C155 brpdsRNA.C.Scer\UAS neurophysiology defective (with Df(2R)BSC29) brp69 visible, with Scer\GAL4pnr-MD237 brpGD7874 brpGD10046 Phenotype manifest in Allele chaeta | supernumerary, with Scer\GAL4pnr-MD237 brpGD7874 embryonic/larval neuromuscular junction brp69 mesothoracic tergum, with Scer\GAL4pnr-MD237 brpGD10046 brpGD7874 t-bar brp69 t-bar, with Scer\GAL4elav-C155 brpdsRNA.C.Scer\UAS t-bar, with Scer\GAL4GMR.PF brpdsRNA.C.Scer\UAS
Classical Alleles ( 11 )
For All Classical Alleles Show
Allele of brp Class Mutagen Stocks Known lesion brp5-HA-1511 1 -- brpc04298 1 -- brpd00208 1 -- brpd09839 1 -- brpf01241b 1 -- brpf02174 1 -- brpKG04653b 1 -- brpMB09517 1 -- brp69 Delta2-3 0 Yes brpMI02987 0 -- brpScer\UAS.T:Disc\RFP-mRFP 0 --
Alleles Carried on Transgenic Constructs ( 16 )
For All Alleles Carried on Transgenic Constructs Show
Allele of brp Class Mutagen Stocks Known lesion brpScer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 3 Yes brpGD7874 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes brpGD10045 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes brpGD10046 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes brpJF01932 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes brpKK108677 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes brpKK109577 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes brpKK109701 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes brpKK111455 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes brpdsRNA.B.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes brpdsRNA.C.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes brpGD7875 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes brpS.mb247.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes brpS.Scer\UAS.T:Avic\GFP-CFP in vitro construct - coding region fusion 0 Yes brpS.Scer\UAS.T:Disc\RFP-mCherry in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes brpScer\UAS.cWa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7875} NA P{GD10045} NA P{GD10046} NA P{KK108677} NA P{KK109577} NA P{KK109701} NA P{KK111455} NA P{TRiP.JF01932} NA P{UAS-brp.dsRNA.B} NA P{UAS-brp.dsRNA.C} NA P{UAS-brp.GFP} NA P{UAS-brp.S-CFP} NA P{UAS-brp.W} NA P{UAS-brp-shortmCherry} NA characterization construct P{mb247-brp-shortGFP} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}brpMI02987 NA P{RS5}brp5-HA-1511 NA P{SUPor-P}brpKG04653b NA PBac{PB}brpc04298 NA PBac{WH}brpf01241b NA PBac{WH}brpf02174 NA insertion of mobile activating element P{XP}brpd00208 NA P{XP}brpd09839 NA insertion of enhancer trap binary system Mi{ET1}brpMB09517 No
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 12 terms )
Molecular Function
CV term Evidence References
calcium channel activity inferred from mutant phenotype (Sigrist et al., 2006)
Biological Process
CV term Evidence References
adult locomotory behavior inferred from mutant phenotype (Wagh et al., 2006) anesthesia-resistant memory inferred from direct assay (Knapek et al., 2011) maintenance of presynaptic active zone structure inferred from mutant phenotype (Kittel et al., 2006, Wagh et al., 2006) neuromuscular synaptic transmission inferred from mutant phenotype (Ly et al., 2008) neurotransmitter secretion inferred from mutant phenotype (Kittel et al., 2006) regulation of synaptic plasticity inferred from mutant phenotype (Kittel et al., 2006) short-term memory inferred from direct assay (Knapek et al., 2011) synaptic transmission inferred from mutant phenotype (Ly et al., 2008)
Cellular Component
CV term Evidence References
neuromuscular junction inferred from direct assay (Kohsaka et al., 2007) presynaptic active zone inferred from direct assay (Wagh et al., 2006, Kittel et al., 2006) colocalizes_with presynaptic membrane inferred from direct assay (Kohsaka et al., 2007)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions brp allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61808 DroID - A comprehensive database of gene and protein interactions. • FBgn0259246 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35977
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12472 Dere\GG24080 Dgri\GH19927 Dmoj\GI19884 Dper\GL15294 Dpse\GA11918 Dsec\GM21130 Dsim\GD15383 Dvir\GJ15053 Dwil\GK21819 Dyak\GE19283
Curated drosophilid orthologs	Dpse\GA11918   Dpse\GA11919   Dpse\GA15767   Dpse\GA15768
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL008273-PA Aedes aegypti (mosquito) AGAP010286-PA Anopheles gambiae (mosquito) XP_392541.3 Apis mellifera (honey bee) XP_001948673.1 Acyrthosiphon pisum (pea aphid) BGIBMGA013779-PA Bombyx mori (silk worm) CPIJ017714 Culex pipens (mosquito) ISCW020384-PA Ixodes scapularis (deer tick) LmjF34.0690 Leishmania major (virus) 33287 Monocosta brevicollis (choanoflagellate) XP_001606987.1 Nasonia vitripennis (wasp) 30288 Ostreococcus tauri (green alga) PHUM000649-PA Pediculus humanus (human body louse) 161451 Physcomitrella patens (moss) Smp_165890 Schistosoma mansoni (trematode parasite) XP_973199.2 Tribolium castaneum (red flour beetle) ENSTRUP00000031213 Takifugu rubripes (pufferfish Takifugu) 86827.m00468 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000002024 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11297 NV10238 LH11035 ISCW020384 FBgn0236636 FBgn0232789 FBgn0223806 FBgn0223805 FBgn0202254 FBgn0202253 FBgn0187052 FBgn0176012 FBgn0171816 JGI_V11_14447 FBgn0246354 FBgn0075784 FBgn0148022 FBgn0142623 FBgn0142622 FBgn0127393 FBgn0127392 FBgn0116221 FBgn0116220 FBgn0089507 FBgn0089508 CPIJ017714 BGIBMGA013779 ACYPI003779 GB19596 AGAP010286 AAEL008273 AAEL008265 PHUM380940 GLEAN_10156
Stocks & Reagents
Stocks Listed in FlyBase ( 20 )
Bloomington	35848 P{UAS-brp.GFP}1, w*
Harvard	- P{XP}brpd00208 - P{XP}brpd09839 - PBac{PB}brpc04298 - PBac{WH}brpf02174
VDRC	v104422 P{KK108677}VIE-260B v104630 P{KK111455}VIE-260B v107748 P{KK109701}VIE-260B v107925 P{KK109577}VIE-260B v38746 w1118; P{GD7874}v38746 v38748 w1118; P{GD7874}v38748 v21135 w1118; P{GD10046}v21135
	More stocks available...
Genomic Clones ( 2 )
	BACR14J24 BACR48G21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 53 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT09405 IP09541
Other clones	IP11737 MIP02718
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT07774 AT26383 HL02476 HL04211 RH42027 RH59150
Other clones	9690 29418 38417 39287 62581 73071 74926 121275 145925 161717 165128 166532 174733 214211.9 214249.42 214351.51 214511.50 CK01.6C.A6 CK01.13A.F3 CK01.143B.D9 CK01.170A.D1 EK008905 EK009527 EK063904 EK103627 EK121851 EK121854 EK137237 EK151618 EK156263 EK174346 EK188539 EK204964 EK248442 EK266019 EK269635 EK302207 EP09337 EP19929 IP09241 IP09341 IP09656 IP11937
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0259246 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35976 35977 35978 246547
Antibody Information
	monoclonal (Marrus and DiAntonio, 2004, Jiao et al., 2010, Knapek et al., 2011, Jiao et al., 2010)
Other Information
Discoverer
Etymology
	'bruchpilot' is German for 'crash pilot'. (Nieratschker, 2005) Named "bruchpilot" as mutants for this gene display unstable flight and quickly crash to the ground. (Wagh et al., 2006)
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: brp CG12932 (FlyBase Genome Annotators, 2008) Source for merge of: brp CG12933 CG30336 CG30337 (Sigrist, 2006.2.28) Source for merge of: brp Mabnc82 (Wagh et al., 2006)
Additional comments	Annotations CG34146 and CG12932 merged as CG42344 in release 5.9 of the genome annotation. (FlyBase Genome Annotators, 2008) Annotations CG12933, CG30336 and CG30337 merged as CG34146 (which corresponds to brp) in release 5.1 of the genome annotation. (FlyBase Genome Annotators, 2006) Annotation CG1931 split into CG30337 and CG30336 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
Other Comments
	brp plays a role in promoting calcium channel clustering at the active zone. (Kittel et al., 2006) brp mutant neuromuscular synapses suffer from active zone membrane defects, a complete loss of presynaptic dense bodies and severely depressed evoked vesicle release. Presynaptic Ca2+-channels become diffusely distributed in brp mutants. (Sigrist et al., 2006) RNAi knockdown flies show synaptic defects, impairment of walking behaviour and unstable flight. (Nieratschker, 2005) Encodes a protein which is expressed in the neuropil structures of the adult brain. (Laissue et al., 1999)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136649 NM_165677 NM_206063 NM_001043070 NM_001103771 RefSeq (Proteins) • NP_610493 NP_724796 NP_995785 NP_001036535 NP_001097241 DDBJ / EMBL / GenBank • AAF58930 AAF58931 AAM50100 AAM71068 AAS64886 ABV53738 AJ849544 AY119446 BF495753 CAH61079 Entrez Gene - A searchable database of RefSeq genes. • 35977 UniProtKB/TrEMBL • A1Z7V1 A1Z7V2 A8DY79 Q8MRS3 Q25B55
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • CAZ complex, RIM-binding protein (IPR019323)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61808 DroID - A comprehensive database of gene and protein interactions. • FBgn0259246 DRSC - Results from RNAi screens. • FBgn0259246 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259246 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12932-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0259246 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35976 35977 35978 246547 InParanoid A subset of ortholog calls from InParanoid. • AAEL008273-PA Aedes aegypti (mosquito) AGAP010286-PA Anopheles gambiae (mosquito) XP_392541.3 Apis mellifera (honey bee) XP_001948673.1 Acyrthosiphon pisum (pea aphid) BGIBMGA013779-PA Bombyx mori (silk worm) CPIJ017714 Culex pipens (mosquito) ISCW020384-PA Ixodes scapularis (deer tick) LmjF34.0690 Leishmania major (virus) 33287 Monocosta brevicollis (choanoflagellate) XP_001606987.1 Nasonia vitripennis (wasp) 30288 Ostreococcus tauri (green alga) PHUM000649-PA Pediculus humanus (human body louse) 161451 Physcomitrella patens (moss) Smp_165890 Schistosoma mansoni (trematode parasite) XP_973199.2 Tribolium castaneum (red flour beetle) ENSTRUP00000031213 Takifugu rubripes (pufferfish Takifugu) 86827.m00468 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000002024 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35977 modMine - Data generated by the modENCODE project. • FBgn0259246 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11297 NV10238 LH11035 ISCW020384 FBgn0236636 FBgn0232789 FBgn0223806 FBgn0223805 FBgn0202254 FBgn0202253 FBgn0187052 FBgn0176012 FBgn0171816 JGI_V11_14447 FBgn0246354 FBgn0075784 FBgn0148022 FBgn0142623 FBgn0142622 FBgn0127393 FBgn0127392 FBgn0116221 FBgn0116220 FBgn0089507 FBgn0089508 CPIJ017714 BGIBMGA013779 ACYPI003779 GB19596 AGAP010286 AAEL008273 AAEL008265 PHUM380940 GLEAN_10156
Synonyms & Secondary IDs ( 23 )
Reported As
Symbol Synonym	BRP (Bogdanik et al., 2008, Banovic et al., 2010, Wagh et al., 2006, Kittel et al., 2006, Kittel et al., 2006, Besse et al., 2007, Vijayakrishnan et al., 2009, Rushton et al., 2009, Gilestro et al., 2009, Fouquet et al., 2009, Iyengar et al., 2006, Li et al., 2007, Nieratschker et al., 2009, Chen et al., 2010, Higashi-Kovtun et al., 2010, Kim et al., 2010, Hamanaka and Meinertzhagen, 2010, Sun et al., 2011, Danjo et al., 2011, Han et al., 2011, Damulewicz and Pyza, 2011, Rossetto et al., 2011) brp (Kurshan et al., 2009, Ratnaparkhi et al., 2008, Wagh et al., 2006, Kim et al., 2009, Daniels et al., 2008, Graf et al., 2009, Cook et al., 2010.2.12, Mauss et al., 2009, Johnson et al., 2009, Owald et al., 2010, Boerner and Duch, 2010, Tsurudome et al., 2010, Lee and Wu, 2010, Knapek et al., 2011, Christiansen et al., 2011, Hallermann et al., 2010) Brp (Giagtzoglou et al., 2009, Chouhan et al., 2010, Mosca and Schwarz, 2010, Zeng et al., 2007, Kohsaka et al., 2007, Pielage et al., 2008, Frank et al., 2009, Chiang et al., 2009, Lin et al., 2009, Ly et al., 2008, Pack-Chung et al., 2007, Barber et al., 2009, Koch et al., 2008, Fuentes-Medel et al., 2009, Johnson et al., 2009, Viquez et al., 2009, Sánchez-Soriano et al., 2010, Bachmann et al., 2010, Inaki et al., 2010, Bachmann et al., 2010, Choi et al., 2010, Nagai et al., 2010, Baas et al., 2011, Pilgram et al., 2011, Liu et al., 2011, Müller et al., 2011, O'Connor-Giles et al., 2008, Peled and Isacoff, 2011, Carlsson et al., 2010, Vrailas-Mortimer et al., 2011, Rohrbough and Broadie, 2010) bruchpilot (Viquez et al., 2006) Cast (Buchner, 2004.10.12) CG1931 (Anholt and Mackay, 2001, ) CG12932 (Wagh et al., 2006, Keleman et al., 2009.8.5) CG12933   CG30336 (Wendler et al., 2010, ) CG30337 (Giot et al., 2003, Rehwinkel et al., 2006, Firth and Baker, 2007) CG34146 (FlyBase Genome Annotators, 2006, Keleman et al., 2009.8.5) CG42344 (FlyBase Genome Annotators, 2008, Perkins et al., 1.15.2009) mAb nc82 (Komiyama et al., 2004, Heimbeck et al., 1999) MAbnc82 (Ashraf et al., 2006) Mabnc82   mAbnc82 (Kain et al., 2009) nc82 (Python and Stocker, 2002, Hong et al., 2009, Hattori et al., 2007, Koh et al., 2007, Ohyama et al., 2007, Baker et al., 2007, Doherty et al., 2009, Liebl et al., 2008, Chen and Hing, 2008, Benton et al., 2007, Sweeney et al., 2007, Dahanukar et al., 2007, Nicolaï et al., 2010, Tamura et al., 2010, Liu et al., 2007, Komiyama, 2007, Kreher et al., 2005, Goldman et al., 2005, Berdnik et al., 2006, Ang et al., 2006, Ataman et al., 2006, Dudu et al., 2006, Dickman, 2006, Dickman et al., 2006, Longair et al., 2007, Hiesinger et al., 2005, Fishilevich et al., 2005, Liu et al., 2006, Yoshihara et al., 2005, Ramaekers et al., 2005, Pielage et al., 2005, Fishilevich and Vosshall, 2005, Larsson et al., 2004, Wang et al., 2004, Wucherpfennig et al., 2003, Marie et al., 2004, Yu et al., 2004, Hummel and Zipursky, 2004, Zhu and Luo, 2004, Jefferis et al., 2002, Zhu et al., 2003, Hummel et al., 2003, Pereanu and Hartenstein, 2003, Rein et al., 2002, Jefferis et al., 2001, Scott et al., 2001, Vosshall et al., 2000, Zhu et al., 2006, Mehta, 2005, Zhai et al., 2006, Kurtovic et al., 2007, Pielage et al., 2006, Jefferis et al., 2007, Wilson and Laurent, 2005, Wu et al., 2005, Dekker et al., 2006, Beuchle et al., 2007, Park et al., 2002, Datta et al., 2008, Lai et al., 2008, Loewen et al., 2006, Nakayama et al., 2006, Fischer et al., 2009, Edwards and Meinertzhagen, 2009, Benton et al., 2009, Ishimoto et al., 2009, Yu et al., 2009, Gu et al., 2009, Mao and Davis, 2009, Iyengar et al., 2006, Rothenfluh et al., 2006, Joseph et al., 2009, Claridge-Chang et al., 2009, Pack-Chung et al., 2007, Berdnik et al., 2008, Izergina et al., 2009, Belay et al., 2007, Dickman and Davis, 2009, Li et al., 2010, Sokol et al., 2008, Miyamoto and Amrein, 2008, Bao et al., 2007, Koganezawa et al., 2010, Potter et al., 2010, Blagburn, 2008, Tanaka et al., 2008, Fergestad et al., 2010, Das et al., 2008, Chou et al., 2010, Tea et al., 2010, Repnikova et al., 2010, Schulte et al., 2010, Cachero et al., 2010, Hamanaka and Meinertzhagen, 2010, Cognigni et al., 2011, Morante et al., 2011, Albornoz et al., 2008, Kahsai and Winther, 2011) Nc82 (Oh et al., 2008, Mahr and Aberle, 2006, Lichtneckert et al., 2007, Guerrero et al., 2005, Lichtneckert et al., 2008, O'Connor-Giles et al., 2008, Haussmann et al., 2008, Fouquet et al., 2009, Rasse et al., 2005, Lee and Wu, 2010) NC82 (Collins et al., 2006, Miller et al., 2005, Marrus and DiAntonio, 2004, Dulcis and Levine, 2005, Wu et al., 2005, Romero-Pozuelo et al., 2007, Cayirlioglu et al., 2008, Qurashi et al., 2007, Jiao et al., 2010, Neely et al., 2010, Liu et al., 2010, Han et al., 2011, James and Broihier, 2011) nc-82 (Zhang et al., 2009)
Name Synonym	Bruchpilot (Bogdanik et al., 2008, Koh et al., 2007, Das et al., 2010, Liebl et al., 2008, Ratnaparkhi et al., 2008, Oh et al., 2008, Chen and Hing, 2008, Chouhan et al., 2010, Banovic et al., 2010, Nicolaï et al., 2010, Mosca and Schwarz, 2010, Pielage et al., 2006, Stowers and Isacoff, 2007, Schmid et al., 2006, Vijayakrishnan et al., 2009, Fischer et al., 2009, Wairkar et al., 2009, Edwards and Meinertzhagen, 2009, Qurashi et al., 2007, Kim et al., 2009, Frank et al., 2009, Ishimoto et al., 2009, Gilestro et al., 2009, Gu et al., 2009, Fouquet et al., 2009, Iyengar et al., 2006, Kain et al., 2009, Wairkar et al., 2008, Daniels et al., 2008, Ly et al., 2008, Graf et al., 2009, Kohsaka et al., 2007, Fuentes-Medel et al., 2009, Johnson et al., 2009, Viquez et al., 2009, Nieratschker et al., 2009, Blagburn, 2008, Sánchez-Soriano et al., 2010, Owald et al., 2010, Kim et al., 2010, Marie et al., 2010, Inaki et al., 2010, Choi et al., 2010, Nagai et al., 2010, Tsurudome et al., 2010, Baas et al., 2011, Pilgram et al., 2011, Roy et al., 2007, Gohl et al., 2011, Zeng et al., 2007, Liu et al., 2011, Sun et al., 2011, Lee and Wu, 2010, Knapek et al., 2011, Albornoz et al., 2008, Kahsai and Winther, 2011, Schmid et al., 2008, James and Broihier, 2011, Kuromi et al., 2010, Rohrbough and Broadie, 2010) bruchpilot (Kurshan et al., 2009, Baker et al., 2007, Sigrist, 2006.2.28, Nieratschker, 2005, Sigrist et al., 2006, Wagh et al., 2006, Pielage et al., 2006, Koch et al., 2008, O'Connor-Giles et al., 2008, Tanaka et al., 2008, Li et al., 2007, Huntwork and Littleton, 2007, Mauss et al., 2009, Chen et al., 2010, Higashi-Kovtun et al., 2010, Schulte et al., 2010, Boerner and Duch, 2010, Young and Armstrong, 2010, White et al., 2010, Spokony and Restifo, 2009, Knight et al., 2010) BRUCHPILOT (Danjo et al., 2011) CG12932   CG42344 (FlyBase Genome Annotators, 2008) Monoclonal antibody nc82 (Laissue et al., 1999) Nc82 (Guerrero et al., 2005)
Secondary FlyBase IDs
	FBgn0027377 FBgn0033418 FBgn0033419 FBgn0033420 FBgn0050336 FBgn0050337 FBgn0083982 FBgn0086376
References ( 232 )
Generate a list of	All references relating to this gene ( 232 )
List References by type	Research paper  ( 205 ) Supplementary material  ( 9 ) Review  ( 1 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 4 ) FlyBase analysis  ( 4 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 1 )
Recent research papers ( 60 )
	Baas et al., 2011, Development 138(3): 553--563 Sugar-free frosting, a homolog of SAD kinase, drives neural-specific glycan expression in the Drosophila embryo. [FBrf0212690] Christiansen et al., 2011, J. Neurosci. 31(26): 9696--9707 Presynapses in Kenyon Cell Dendrites in the Mushroom Body Calyx of Drosophila. [FBrf0214059] Cognigni et al., 2011, Cell Metab. 13(1): 92--104 Enteric neurons and systemic signals couple nutritional and reproductive status with intestinal homeostasis. [FBrf0212594] Damulewicz and Pyza, 2011, PLoS ONE 6(6): e21258 The Clock Input to the First Optic Neuropil of Drosophila melanogaster Expressing Neuronal Circadian Plasticity. [FBrf0214354] Danjo et al., 2011, PLoS ONE 6(2): e17131 A tripartite synapse model in Drosophila. [FBrf0213114] Gohl et al., 2011, Nat. Methods 8(3): 231--237 A versatile in vivo system for directed dissection of gene expression patterns. [FBrf0213287] Han et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(23): 9673--9678 Enhancer-driven membrane markers for analysis of nonautonomous mechanisms reveal neuron-glia interactions in Drosophila. [FBrf0213916] James and Broihier, 2011, Development 138(15): 3273--3286 Crimpy inhibits the BMP homolog Gbb in motoneurons to enable proper growth control at the Drosophila neuromuscular junction. [FBrf0214390] Kahsai and Winther, 2011, J. Comp. Neurol. 519(2): 290--315 Chemical neuroanatomy of the Drosophila central complex: distribution of multiple neuropeptides in relation to neurotransmitters. [FBrf0212649] Knapek et al., 2011, J. Neurosci. 31(9): 3453--3458 Bruchpilot, a synaptic active zone protein for anesthesia-resistant memory. [FBrf0213189] Liu et al., 2011, J. Neurosci. 31(6): 2052--2063 Drosophila Acyl-CoA Synthetase Long-Chain Family Member 4 Regulates Axonal Transport of Synaptic Vesicles and Is Required for Synaptic Development and Transmission. [FBrf0212968] Morante et al., 2011, Development 138(4): 687--693 Cell migration in Drosophila optic lobe neurons is controlled by eyeless/Pax6. [FBrf0212874] Müller et al., 2011, Neuron 69(4): 749--762 Rab3-GAP Controls the Progression of Synaptic Homeostasis at a Late Stage of Vesicle Release. [FBrf0213055] Peled and Isacoff, 2011, Nat. Neurosci. 14(4): 519--526 Optical quantal analysis of synaptic transmission in wild-type and rab3-mutant Drosophila motor axons. [FBrf0213336] Pilgram et al., 2011, J. Neurosci. 31(2): 492--500 The RhoGAP crossveinless-c Interacts with Dystrophin and Is Required for Synaptic Homeostasis at the Drosophila Neuromuscular Junction. [FBrf0212767] Rossetto et al., 2011, Hum. Mol. Genet. 20(21): 4248--4257 Defhc1.1, a homologue of the juvenile myoclonic gene EFHC1, modulates architecture and basal activity of the neuromuscular junction in Drosophila. [FBrf0216330] Sun et al., 2011, J. 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