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Gene Dmel\Mob3

General Information
Symbol	Dmel\Mob3	Species	D. melanogaster
Name		Annotation symbol	CG4946
Feature type	protein_coding_gene	FlyBase ID	FBgn0259482
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	dmob3
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	31B1-31B1	Sequence location	2L:10,265,339..10,266,570 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\Mob3 (CG4946, FBgn0259482). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Mob1/phocein. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1629158_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Mob3. Gene sequence location is 2L:10265339..10266570.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN29447 HFA02791
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 31B1-31B1   Limits computationally determined from genome sequence between P{lacW}me31Bk06607 and P{PZ}nmd08774
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Mob3 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Mob3-RA FBtr0079983  NM_135520   909   220
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Mob3-PA   FBpp0079573   25.5   220   8.31     NP_609364   AAF52892
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Mob1/phocein (IPR005301)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA697948   AE014134 AAF52892   AY071000 AAL48622   BE978286   BI168259   BP548640   BP553581   BP553582   BP559970   BP559971   CO189392   CO277527   CO320287   CO322803   CO344508   EC060295   EC074943   EC080701   EC211931   EC216010   EC256309   EL876987
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VL13
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0259482    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0259482 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0259482 expression level Developmental Stage   Expression Level embryo 00-02hr    2203 embryo 02-04hr    1041 embryo 04-06hr    1049 embryo 06-08hr    1049 embryo 08-10hr    1194 embryo 10-12hr    891 embryo 12-14hr    976 embryo 14-16hr    314 embryo 16-18hr    377 embryo 18-20hr    234 embryo 20-22hr    308 embryo 22-24hr    399 larva L1    358 larva L2    549 larva L3 12hr old    471 larva L3 puffstage 1-2    701 larva L3 puffstage 3-6    767 larva L3 puffstage 7-9    957 white prepupae new    837 white prepupae 12hr    918 white prepupae 24hr    921 pupae 2d postWPP    809 pupae 3d postWPP    532 pupae 4d postWPP    258 adult male 01day    589 adult male 05day    674 adult male 30day    582 adult female 01day    578 adult female 05day    1710 adult female 30day    1629 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2203) embryo 02-04hr  (1041) embryo 04-06hr  (1049) embryo 06-08hr  (1049) embryo 08-10hr  (1194) embryo 10-12hr  (891) embryo 12-14hr  (976) embryo 14-16hr  (314) embryo 16-18hr  (377) embryo 18-20hr  (234) embryo 20-22hr  (308) embryo 22-24hr  (399) larva L1  (358) larva L2  (549) larva L3 12hr old  (471) larva L3 puffstage 1-2  (701) larva L3 puffstage 3-6  (767) larva L3 puffstage 7-9  (957) white prepupae new  (837) white prepupae 12hr  (918) white prepupae 24hr  (921) pupae 2d postWPP  (809) pupae 3d postWPP  (532) pupae 4d postWPP  (258) adult male 01day  (589) adult male 05day  (674) adult male 30day  (582) adult female 01day  (578) adult female 05day  (1710) adult female 30day  (1629) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2203) embryo 02-04hr    1041 embryo 04-06hr    1049 embryo 06-08hr    1049 embryo 08-10hr    1194 embryo 10-12hr    891 embryo 12-14hr    976 embryo 14-16hr    314 embryo 16-18hr    377 embryo 18-20hr    234 embryo 20-22hr    308 embryo 22-24hr    399 larva L1    358 larva L2    549 larva L3 12hr old    471 larva L3 puffstage 1-2    701 larva L3 puffstage 3-6    767 larva L3 puffstage 7-9    957 white prepupae new    837 white prepupae 12hr    918 white prepupae 24hr    921 pupae 2d postWPP    809 pupae 3d postWPP    532 pupae 4d postWPP    258 adult male 01day    589 adult male 05day    674 adult male 30day    582 adult female 01day    578 adult female 05day  (1710) adult female 30day  (1629) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2203 embryo 02-04hr    1041 embryo 04-06hr    1049 embryo 06-08hr    1049 embryo 08-10hr    1194 embryo 10-12hr    891 embryo 12-14hr    976 embryo 14-16hr    314 embryo 16-18hr    377 embryo 18-20hr    234 embryo 20-22hr    308 embryo 22-24hr    399 larva L1    358 larva L2    549 larva L3 12hr old    471 larva L3 puffstage 1-2    701 larva L3 puffstage 3-6    767 larva L3 puffstage 7-9    957 white prepupae new    837 white prepupae 12hr    918 white prepupae 24hr    921 pupae 2d postWPP    809 pupae 3d postWPP    532 pupae 4d postWPP    258 adult male 01day    589 adult male 05day    674 adult male 30day    582 adult female 01day    578 adult female 05day    1710 adult female 30day    1629 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2203 embryo 02-04hr    1041 embryo 04-06hr    1049 embryo 06-08hr    1049 embryo 08-10hr    1194 embryo 10-12hr    891 embryo 12-14hr    976 embryo 14-16hr    314 embryo 16-18hr    377 embryo 18-20hr    234 embryo 20-22hr    308 embryo 22-24hr    399 larva L1    358 larva L2    549 larva L3 12hr old    471 larva L3 puffstage 1-2    701 larva L3 puffstage 3-6    767 larva L3 puffstage 7-9    957 white prepupae new    837 white prepupae 12hr    918 white prepupae 24hr    921 pupae 2d postWPP    809 pupae 3d postWPP    532 pupae 4d postWPP    258 adult male 01day    589 adult male 05day    674 adult male 30day    582 adult female 01day    578 adult female 05day    1710 adult female 30day    1629 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0259482 expression level Developmental Stage   Expression Level embryo 00-02hr    2203 embryo 02-04hr    1041 embryo 04-06hr    1049 embryo 06-08hr    1049 embryo 08-10hr    1194 embryo 10-12hr    891 embryo 12-14hr    976 embryo 14-16hr    314 embryo 16-18hr    377 embryo 18-20hr    234 embryo 20-22hr    308 embryo 22-24hr    399 larva L1    358 larva L2    549 larva L3 12hr old    471 larva L3 puffstage 1-2    701 larva L3 puffstage 3-6    767 larva L3 puffstage 7-9    957 white prepupae new    837 white prepupae 12hr    918 white prepupae 24hr    921 pupae 2d postWPP    809 pupae 3d postWPP    532 pupae 4d postWPP    258 adult male 01day    589 adult male 05day    674 adult male 30day    582 adult female 01day    578 adult female 05day    1710 adult female 30day    1629 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2203) embryo 02-04hr  (1041) embryo 04-06hr  (1049) embryo 06-08hr  (1049) embryo 08-10hr  (1194) embryo 10-12hr  (891) embryo 12-14hr  (976) embryo 14-16hr  (314) embryo 16-18hr  (377) embryo 18-20hr  (234) embryo 20-22hr  (308) embryo 22-24hr  (399) larva L1  (358) larva L2  (549) larva L3 12hr old  (471) larva L3 puffstage 1-2  (701) larva L3 puffstage 3-6  (767) larva L3 puffstage 7-9  (957) white prepupae new  (837) white prepupae 12hr  (918) white prepupae 24hr  (921) pupae 2d postWPP  (809) pupae 3d postWPP  (532) pupae 4d postWPP  (258) adult male 01day  (589) adult male 05day  (674) adult male 30day  (582) adult female 01day  (578) adult female 05day  (1710) adult female 30day  (1629) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  2203 embryo 02-04hr    1041 embryo 04-06hr    1049 embryo 06-08hr    1049 embryo 08-10hr    1194 embryo 10-12hr    891 embryo 12-14hr    976 embryo 14-16hr    314 embryo 16-18hr    377 embryo 18-20hr    234 embryo 20-22hr    308 embryo 22-24hr    399 larva L1    358 larva L2    549 larva L3 12hr old    471 larva L3 puffstage 1-2    701 larva L3 puffstage 3-6    767 larva L3 puffstage 7-9    957 white prepupae new    837 white prepupae 12hr    918 white prepupae 24hr    921 pupae 2d postWPP    809 pupae 3d postWPP    532 pupae 4d postWPP    258 adult male 01day    589 adult male 05day    674 adult male 30day    582 adult female 01day    578 adult female 05day  1710 adult female 30day  1629 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2203 embryo 02-04hr    1041 embryo 04-06hr    1049 embryo 06-08hr    1049 embryo 08-10hr    1194 embryo 10-12hr    891 embryo 12-14hr    976 embryo 14-16hr    314 embryo 16-18hr    377 embryo 18-20hr    234 embryo 20-22hr    308 embryo 22-24hr    399 larva L1    358 larva L2    549 larva L3 12hr old    471 larva L3 puffstage 1-2    701 larva L3 puffstage 3-6    767 larva L3 puffstage 7-9    957 white prepupae new    837 white prepupae 12hr    918 white prepupae 24hr    921 pupae 2d postWPP    809 pupae 3d postWPP    532 pupae 4d postWPP    258 adult male 01day    589 adult male 05day    674 adult male 30day    582 adult female 01day    578 adult female 05day    1710 adult female 30day    1629 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2203 embryo 02-04hr    1041 embryo 04-06hr    1049 embryo 06-08hr    1049 embryo 08-10hr    1194 embryo 10-12hr    891 embryo 12-14hr    976 embryo 14-16hr    314 embryo 16-18hr    377 embryo 18-20hr    234 embryo 20-22hr    308 embryo 22-24hr    399 larva L1    358 larva L2    549 larva L3 12hr old    471 larva L3 puffstage 1-2    701 larva L3 puffstage 3-6    767 larva L3 puffstage 7-9    957 white prepupae new    837 white prepupae 12hr    918 white prepupae 24hr    921 pupae 2d postWPP    809 pupae 3d postWPP    532 pupae 4d postWPP    258 adult male 01day    589 adult male 05day    674 adult male 30day    582 adult female 01day    578 adult female 05day    1710 adult female 30day    1629 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0259482    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0259482 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0259482 expression level Tissue   Expression Level Larval Central Nervous System    318.6 Larval Midgut    66.8 Larval Hindgut    149.9 Larval Malpighian Tubules    279.5 Larval Fat Body    228.6 Larval Salivary Gland    289.8 Larval Trachea    261.25 Larval Carcass    177.85 Adult Head    305.3 Adult Eye    448.05 Adult Brain    306.7 Adult Thoracic-Abdominal Ganglion    330.9 Adult Crop    308.1 Adult Midgut    96.6 Adult Hindgut    207.4 Adult Malpighian Tubules    135.5 Adult Fat Body    170.6 Adult Salivary Gland    453.5 Adult Heart    220.4 Adult VirginFemale Spermatheca    287.7 Adult InseminatedFemale Spermatheca    277.9 Adult Ovary    455.2 Adult Testis    129.7 Adult Male Accessory Gland    400.1 Adult Carcass    201.7 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    318.6 Larval Midgut    66.8 Larval Hindgut    149.9 Larval Malpighian Tubules    279.5 Larval Fat Body    228.6 Larval Salivary Gland    289.8 Larval Trachea    261.25 Larval Carcass    177.85 Adult Head    305.3 Adult Eye    448.05 Adult Brain    306.7 Adult Thoracic-Abdominal Ganglion    330.9 Adult Crop    308.1 Adult Midgut    96.6 Adult Hindgut    207.4 Adult Malpighian Tubules    135.5 Adult Fat Body    170.6 Adult Salivary Gland    453.5 Adult Heart    220.4 Adult VirginFemale Spermatheca    287.7 Adult InseminatedFemale Spermatheca    277.9 Adult Ovary    455.2 Adult Testis    129.7 Adult Male Accessory Gland    400.1 Adult Carcass    201.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    318.6 Larval Midgut    66.8 Larval Hindgut    149.9 Larval Malpighian Tubules    279.5 Larval Fat Body    228.6 Larval Salivary Gland    289.8 Larval Trachea    261.25 Larval Carcass    177.85 Adult Head    305.3 Adult Eye    448.05 Adult Brain    306.7 Adult Thoracic-Abdominal Ganglion    330.9 Adult Crop    308.1 Adult Midgut    96.6 Adult Hindgut    207.4 Adult Malpighian Tubules    135.5 Adult Fat Body    170.6 Adult Salivary Gland    453.5 Adult Heart    220.4 Adult VirginFemale Spermatheca    287.7 Adult InseminatedFemale Spermatheca    277.9 Adult Ovary    455.2 Adult Testis    129.7 Adult Male Accessory Gland    400.1 Adult Carcass    201.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    318.6 Larval Midgut    66.8 Larval Hindgut    149.9 Larval Malpighian Tubules    279.5 Larval Fat Body    228.6 Larval Salivary Gland    289.8 Larval Trachea    261.25 Larval Carcass    177.85 Adult Head    305.3 Adult Eye    448.05 Adult Brain    306.7 Adult Thoracic-Abdominal Ganglion    330.9 Adult Crop    308.1 Adult Midgut    96.6 Adult Hindgut    207.4 Adult Malpighian Tubules    135.5 Adult Fat Body    170.6 Adult Salivary Gland    453.5 Adult Heart    220.4 Adult VirginFemale Spermatheca    287.7 Adult InseminatedFemale Spermatheca    277.9 Adult Ovary    455.2 Adult Testis    129.7 Adult Male Accessory Gland    400.1 Adult Carcass    201.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0259482 expression level Tissue   Expression Level Larval Central Nervous System    318.6 Larval Midgut    66.8 Larval Hindgut    149.9 Larval Malpighian Tubules    279.5 Larval Fat Body    228.6 Larval Salivary Gland    289.8 Larval Trachea    261.25 Larval Carcass    177.85 Adult Head    305.3 Adult Eye    448.05 Adult Brain    306.7 Adult Thoracic-Abdominal Ganglion    330.9 Adult Crop    308.1 Adult Midgut    96.6 Adult Hindgut    207.4 Adult Malpighian Tubules    135.5 Adult Fat Body    170.6 Adult Salivary Gland    453.5 Adult Heart    220.4 Adult VirginFemale Spermatheca    287.7 Adult InseminatedFemale Spermatheca    277.9 Adult Ovary    455.2 Adult Testis    129.7 Adult Male Accessory Gland    400.1 Adult Carcass    201.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    318.6 Larval Midgut    66.8 Larval Hindgut    149.9 Larval Malpighian Tubules    279.5 Larval Fat Body    228.6 Larval Salivary Gland    289.8 Larval Trachea    261.25 Larval Carcass    177.85 Adult Head    305.3 Adult Eye    448.05 Adult Brain    306.7 Adult Thoracic-Abdominal Ganglion    330.9 Adult Crop    308.1 Adult Midgut    96.6 Adult Hindgut    207.4 Adult Malpighian Tubules    135.5 Adult Fat Body    170.6 Adult Salivary Gland    453.5 Adult Heart    220.4 Adult VirginFemale Spermatheca    287.7 Adult InseminatedFemale Spermatheca    277.9 Adult Ovary    455.2 Adult Testis    129.7 Adult Male Accessory Gland    400.1 Adult Carcass    201.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    318.6 Larval Midgut    66.8 Larval Hindgut    149.9 Larval Malpighian Tubules    279.5 Larval Fat Body    228.6 Larval Salivary Gland    289.8 Larval Trachea    261.25 Larval Carcass    177.85 Adult Head    305.3 Adult Eye    448.05 Adult Brain    306.7 Adult Thoracic-Abdominal Ganglion    330.9 Adult Crop    308.1 Adult Midgut    96.6 Adult Hindgut    207.4 Adult Malpighian Tubules    135.5 Adult Fat Body    170.6 Adult Salivary Gland    453.5 Adult Heart    220.4 Adult VirginFemale Spermatheca    287.7 Adult InseminatedFemale Spermatheca    277.9 Adult Ovary    455.2 Adult Testis    129.7 Adult Male Accessory Gland    400.1 Adult Carcass    201.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    318.6 Larval Midgut    66.8 Larval Hindgut    149.9 Larval Malpighian Tubules    279.5 Larval Fat Body    228.6 Larval Salivary Gland    289.8 Larval Trachea    261.25 Larval Carcass    177.85 Adult Head    305.3 Adult Eye    448.05 Adult Brain    306.7 Adult Thoracic-Abdominal Ganglion    330.9 Adult Crop    308.1 Adult Midgut    96.6 Adult Hindgut    207.4 Adult Malpighian Tubules    135.5 Adult Fat Body    170.6 Adult Salivary Gland    453.5 Adult Heart    220.4 Adult VirginFemale Spermatheca    287.7 Adult InseminatedFemale Spermatheca    277.9 Adult Ovary    455.2 Adult Testis    129.7 Adult Male Accessory Gland    400.1 Adult Carcass    201.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    305.3   NA  Eye    448.05   NA  Brain    306.7   318.6  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    330.9   NA  Crop    308.1   66.8  Midgut    96.6   149.9  Hindgut    207.4   279.5  Malpighian Tubules    135.5   228.6  Fat Body    170.6   289.8  Salivary Gland    453.5   NA  Heart    220.4   261.25  Trachea    NA   NA  VirginFemale Spermatheca    287.7   NA  InseminatedFemale Spermatheca    277.9   NA  Ovary    455.2   NA  Testis    129.7   NA  Male Accessory Gland    400.1   177.85  Carcass    201.7 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259482 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4946-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Mob3GD10532 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Mob3 Class Mutagen Stocks Known lesion Mob3G17981 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Mob3 Class Mutagen Stocks Known lesion Mob3GD10532 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Mob3KK109447 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6026 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK109447} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Mob3G17981 NA
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
	There is no information supporting a biological process or cellular component term for this gene. (Based on a review of available data on: 2007-02-19)
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Mob3 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0259482 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34372
Orthologs
Genome-wide drosophilid orthologs	Dana\GF15759 Dere\GG10099 Dgri\GH13517 Dmoj\GI18135 Dper\GL18994 Dsec\GM18081 Dsim\GD23671 Dvir\GJ14867 Dyak\GE18913
Curated drosophilid orthologs
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL007325-PA Aedes aegypti (mosquito) AGAP007872-PA Anopheles gambiae (mosquito) XP_396081.2 Apis mellifera (honey bee) XP_001951298.1 Acyrthosiphon pisum (pea aphid) 210581 Branchiostoma floridae (lancelet) XP_001898487.1 Brugia malayi (roundworm nematode) ENSBTAP00000001063 Bos taurus (bovine) CN07114 Caenorhabditis brenneri (small nematode) CBP07163 Caenorhabditis briggsae (nematode) CE21179 Caenorhabditis elegans (worm) ENSCAFP00000002488 Canis familiaris (dog) ENSCINP00000003998 Ciona intestinalis (sea squirt) JA08380 Caenorhabditis japonica (nematode) CMA101C Cyanidioschyzon merolae (red alga) CPIJ009351 Culex pipens (mosquito) ENSCPOP00000008500 Cavia porcellus (guinea pig) RP28092 Caenorhabditis remanei (nematode) ENSCSAVP00000009025 Ciona savignyi (sedentary tunicate) 151090 Capitella spl (polychaete worm) 191064 Daphnia pulex (daphnia) ENSDARP00000021765 Danio rerio (zebra fish) ENSECAP00000019022 Equus caballus (horse) XP_653651 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000015729 Gymnopilus aculeatus (mushroom) ENSGALP00000033993 Gallus gallus (chicken) 106063 Hypsipyla robusta (cedar shoot borer) ENSP00000262244 Homo sapiens (human) ISCW003834-PA Ixodes scapularis (deer tick) 208809 Lottia gigantea (owl limpet) 14634 Monocosta brevicollis (choanoflagellate) ENSMODP00000005289 Monodelphis domestica (gray opossum) ENSMMUP00000026552 Macaca mulatta (rhesus monkey) ENSMUSP00000100040 Mus musculus (house mouse) XP_001607884.1 Nasonia vitripennis (wasp) ENSOANP00000011555 Ornithorynchus anatinus (platypus) ENSORLP00000020718 Oryzias latipes (japanese killifish) PHUM004023-PA Pediculus humanus (human body louse) ENSPPYP00000021462 Pongo pygmaeus (orangutan) ENSPTRP00000035638 Pan troglodytes (chimpanzee) ENSRNOP00000025634 Rattus norvegicus (norway rat) Smp_095470 Schistosoma mansoni (trematode parasite) XP_969194.1 Tribolium castaneum (red flour beetle) ENSTNIP00000009402 Tetraodon nigroviridis (green spotted pufferfish) 38473 Thalassiosira pseudonana (marine diatom) ENSTRUP00000045237 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000029904 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10945 LH21963 ISCW003834 FBgn0236287 FBgn0202071 FBgn0195048 FBgn0172988 JGI_V11_191064 FBgn0156595 FBgn0140875 FBgn0120993 FBgn0102411 FBgn0092783 CPIJ009351 ACYPI001031 GB14885 AGAP007872 AAEL007325 PB20056 PHUM128450 GLEAN_15384
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	28097 y1 w*; P{EP}Mob3G17981/CyO
VDRC	v106853 P{KK109447}VIE-260B v21551 w1118; P{GD10532}v21551 v21550 w1118; P{GD10532}v21550/CyO
Genomic Clones ( 2 )
	BACR07H08 BACR30M19 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 18 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE08857
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	HL03517
Other clones	7426 62927 69972 178473 bs76e09 CK01.54B.E8 EC256309 EK044152 EK125410 EK188946 EK283622 EP19412 FGH129H12 FGM225B10 FGM323H09 IP06912
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0259482 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34372
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Mob3 CG4946 (He et al., 2005)
Source for database merge of
Additional comments
Other Comments
	Identification: on basis of sequence similarity to S. cerevisiae MOB1 (S000001368). (Domingues et al., 2005)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135520 RefSeq (Proteins) • NP_609364 DDBJ / EMBL / GenBank • AAF52892 AAL48622 AY071000 BI168259 Entrez Gene - A searchable database of RefSeq genes. • 34372 UniProtKB/TrEMBL • Q9VL13
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Mob1/phocein (IPR005301)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0259482 DRSC - Results from RNAi screens. • FBgn0259482 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259482 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4946-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0259482 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34372 InParanoid A subset of ortholog calls from InParanoid. • AAEL007325-PA Aedes aegypti (mosquito) AGAP007872-PA Anopheles gambiae (mosquito) XP_396081.2 Apis mellifera (honey bee) XP_001951298.1 Acyrthosiphon pisum (pea aphid) 210581 Branchiostoma floridae (lancelet) XP_001898487.1 Brugia malayi (roundworm nematode) ENSBTAP00000001063 Bos taurus (bovine) CN07114 Caenorhabditis brenneri (small nematode) CBP07163 Caenorhabditis briggsae (nematode) CE21179 Caenorhabditis elegans (worm) ENSCAFP00000002488 Canis familiaris (dog) ENSCINP00000003998 Ciona intestinalis (sea squirt) JA08380 Caenorhabditis japonica (nematode) CMA101C Cyanidioschyzon merolae (red alga) CPIJ009351 Culex pipens (mosquito) ENSCPOP00000008500 Cavia porcellus (guinea pig) RP28092 Caenorhabditis remanei (nematode) ENSCSAVP00000009025 Ciona savignyi (sedentary tunicate) 151090 Capitella spl (polychaete worm) 191064 Daphnia pulex (daphnia) ENSDARP00000021765 Danio rerio (zebra fish) ENSECAP00000019022 Equus caballus (horse) XP_653651 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000015729 Gymnopilus aculeatus (mushroom) ENSGALP00000033993 Gallus gallus (chicken) 106063 Hypsipyla robusta (cedar shoot borer) ENSP00000262244 Homo sapiens (human) ISCW003834-PA Ixodes scapularis (deer tick) 208809 Lottia gigantea (owl limpet) 14634 Monocosta brevicollis (choanoflagellate) ENSMODP00000005289 Monodelphis domestica (gray opossum) ENSMMUP00000026552 Macaca mulatta (rhesus monkey) ENSMUSP00000100040 Mus musculus (house mouse) XP_001607884.1 Nasonia vitripennis (wasp) ENSOANP00000011555 Ornithorynchus anatinus (platypus) ENSORLP00000020718 Oryzias latipes (japanese killifish) PHUM004023-PA Pediculus humanus (human body louse) ENSPPYP00000021462 Pongo pygmaeus (orangutan) ENSPTRP00000035638 Pan troglodytes (chimpanzee) ENSRNOP00000025634 Rattus norvegicus (norway rat) Smp_095470 Schistosoma mansoni (trematode parasite) XP_969194.1 Tribolium castaneum (red flour beetle) ENSTNIP00000009402 Tetraodon nigroviridis (green spotted pufferfish) 38473 Thalassiosira pseudonana (marine diatom) ENSTRUP00000045237 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000029904 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34372 modMine - Data generated by the modENCODE project. • FBgn0259482 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10945 LH21963 ISCW003834 FBgn0236287 FBgn0202071 FBgn0195048 FBgn0172988 JGI_V11_191064 FBgn0156595 FBgn0140875 FBgn0120993 FBgn0102411 FBgn0092783 CPIJ009351 ACYPI001031 GB14885 AGAP007872 AAEL007325 PB20056 PHUM128450 GLEAN_15384
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	CG4946 (He et al., 2005, Keleman et al., 2009.8.5, Schulte et al., 2010) dmob3 (Wainman et al., 2004) DMob3 (Domingues et al., 2005) Dmob3 (Mentelova et al., 2007, He et al., 2005) Mob3 (Schulte et al., 2010)
Name Synonym	CG4946   Mob3 (Domingues et al., 2005)
Secondary FlyBase IDs
	FBgn0032203 FBgn0083173
References ( 14 )
Research paper	Schulte et al., 2010, J. Neurosci. 30(15): 5189--5203 DMob4/Phocein regulates synapse formation, axonal transport, and microtubule organization. [FBrf0210612] He et al., 2005, Molec. Biol. Cell 16(9): 4139--4152 Drosophila mob family proteins interact with the related tricornered (trc) and warts (wts) kinases. [FBrf0188034]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Bellen, 2009.6.29, BDGP_2009_0629.GenExel.xml BDGP_2009_0629.GenExel.xml [FBrf0208121] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] O'Farrell, 2001.9.11, FlyBase error report for CG13852 on Mon Sep 10 18:52:22 2001. FlyBase error report for CG13852 on Mon Sep 10 18:52:22 2001. [FBrf0138586]
Abstract	Mentelova et al., 2007, Europ. Dros. Res. Conf. 20: F020 CHARACTERISATION OF THE DROSOPHILA MELANOGASTER MOB HOMOLOGUES. [FBrf0199824] Domingues et al., 2005, Europ. Dros. Res. Conf. 19: DR6 Centrosomal protein Mob4 is a new tumor supressor. [FBrf0185141] Wainman et al., 2004, A. Dros. Res. Conf. 45 Suppl.: 913A MOB1-like genes in Drosophila melanogaster. [FBrf0179616]
FlyBase analysis	FlyBase Curators, 2002-, Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. [FBrf0159398]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]