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Gene Dmel\crb

General Information
Symbol	Dmel\crb	Species	D. melanogaster
Name	crumbs	Annotation symbol	CG6383
Feature type	protein_coding_gene	FlyBase ID	FBgn0259685
Gene Model Status	Current	Stock availability	22 publicly available
Also Known As	l(3)07207, Crumbs, Crbs
Genomic Location
Chromosome (arm)	3R	Recombination map	3-82
Cytogenetic map	95F10-95F11	Sequence location	3R:20,120,800..20,140,154 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene crumbs is referred to in FlyBase by the symbol Dmel\crb (CG6383, FBgn0259685). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein kinase C binding. There is experimental evidence for 26 unique biological process terms, many of which group under: cellular component organization or biogenesis; biological regulation; cellular process; establishment or maintenance of bipolar cell polarity; sensory organ development; cell junction organization; compound eye photoreceptor development; system development; open tracheal system development; positive regulation of cell proliferation; localization; gland morphogenesis; embryonic development via the syncytial blastoderm; establishment or maintenance of polarity of follicular epithelium; multicellular organism reproduction. 93 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; organ system; external compound sense organ; non-connected developing system; adult segment; adherens junction; peripheral nervous system; spiracle; embryonic hindgut; imaginal precursor; late extended germ band embryo. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Concanavalin A-like lectin/glucanase; Concanavalin A-like lectin/glucanase, subgroup; EGF; EGF-like calcium-binding; EGF-like calcium-binding, conserved site; EGF-like region, conserved site; EGF-type aspartate/asparagine hydroxylation site; Epidermal growth factor-like; Epidermal growth factor-like, type 3; Laminin G domain; Laminin G, subdomain 1; Laminin G, subdomain 2. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 06-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult crop, larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, larval/adult salivary gland, adult ovary, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1628146_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of crb. Gene sequence location is 3R:20120800..20140154.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	crb: crumbs Homozygous lethal; many small holes in cuticle.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Maruyama et al., 2011, PLoS ONE 6(6): e20901
FB2012_01	Controlled Vocabulary Terms invaginating stomatogastric nervous system precursor liquid clearance, open tracheal system References Chartier et al., 2011, J. Cell Sci. 124(20): 3393--3398 Kolahgar et al., 2011, Development 138(14): 3021--3031 Muschalik and Knust, 2011, J. Cell Sci. 124(21): 3715--3725 Stümpges and Behr, 2011, FEBS Lett. 585(20): 3316--3321 Colosimo et al., 2010, Dev. Dyn. 239(1): 115--125 Zhan et al., 2010, PLoS ONE 5(11): e14134 Mui et al., 2011, PLoS ONE 6(10): e25965 Gilbert et al., 2011, Dev. Cell 20(5): 700--712 Sequence features HFA16927 BKN21850
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 95F10-95F11   Limits computationally determined from genome sequence between P{PZ}crb07207&P{PZ}BRWD305842 and P{EP}CycB3EP3127
Experimentally Determined Cytological Location
Cytogenetic map Notes References 95F3-95F10   (determined by in situ hybridisation)   (Harden et al., 2002) 95F11-95F12   (determined by in situ hybridisation)   (Spradling et al., 1999) 95F-95F   (determined by in situ hybridisation) 95F3--10 (determined by in situ hybridisation)   (Szeged Stock Center, 1998-) 95F9-95F13   (determined by in situ hybridisation)   (Ranz et al., 1999) 95F-95F   (determined by in situ hybridisation)   (Deak et al., 1997) 95F11-95F12   (determined by in situ hybridisation)   (Perrimon et al., 1996) 95F11-95F12     (BDGP Project Members, 1994-1999) 99F-99F   (determined by in situ hybridisation)   (Tepass et al., 1990) 95F-95F   (determined by in situ hybridisation)   (Knust et al., 1987)
Experimentally Determined Recombination Data
Location	3-82 (Tearle and Nusslein-Volhard, 1987)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\crb for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) crb-RA FBtr0084603  NM_079756   7543   2146 crb-RB FBtr0111008  NM_001043286   7672   2189 crb-RC FBtr0304726     7864   2253
Additional Transcript Data & Comments
Reported size (kB)	7.7, 7.5 (northern blot) (Tepass et al., 1990)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein crb-PA   FBpp0083987   233.6   2146   4.50     NP_524480   AAF56276 crb-PB   FBpp0110307   238.6   2189   4.53     NP_001036751   ABI31202 crb-PC   FBpp0293268   244.7   2253   4.55
Additional Polypeptide Data & Comments
Reported size (kDa)	2139 (aa); 234 (kD) (Tepass et al., 1990)
Comments	crb protein is used as a marker for the boundary cells that delineate the dorsal and ventral domains of the embryonic large intestine. (Maeda et al., 2007) Four Cys-poor regions of crb are distantly related to domains present in the C-terminal part of laminin-A chains and merosin. This homology suggests that the Cys-poor regions may be directly involved in its role in epithelial organization. (Patthy, 1991)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • EGF-like calcium-binding, conserved site (IPR018097) EGF-type aspartate/asparagine hydroxylation site (IPR000152) Epidermal growth factor-like, type 3 (IPR000742) Laminin G domain (IPR001791) EGF-like calcium-binding (IPR001881) Epidermal growth factor-like (IPR006210) Concanavalin A-like lectin/glucanase (IPR008985) Laminin G, subdomain 2 (IPR012680) EGF-like region, conserved site (IPR013032) Concanavalin A-like lectin/glucanase, subgroup (IPR013320) EGF (IPR006209) Laminin G, subdomain 1 (IPR012679)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA439014   AA538865   AE014297 AAF56276   AE014297 ABI31202   AQ026290   AQ073342   AW942272   AY118509 AAM49878   BH809473   BI165373   BP550115   BP550116   BP554271   BP558611   CL525925   CO185566   CO191688   CO265447   CO267719   CO269501   CO286541   CO287178   CO295035   CO296389   CO300419   CO306941   CO307197   CO308083   CO309327   CO320855   CZ466902   CZ469513   CZ472564   CZ481877   CZ484322   CZ484323   CZ484341   CZ488604   CZ488605   EC060892   EC064272   EC064365   EC065893   EC066185   EC079887   EC081085   EC086262   EC208636   EC229736   EC233832   EC235272   EC245818   EC250614   M33753 AAA28428   X05144 CAA28793   Z71109
UniProtKB/Swiss-Prot	P10040
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage   embryonic/larval hindgut   (Tepass et al., 1990) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage | late   adult salivary gland primordium | dorsal & posterior   (Myat and Andrew, 2002) embryonic stage   epithelium   • cytoplasm | apical (Lecuyer et al., 2007) embryonic stage 5   epithelial cell   • cytoplasm | apical (Lecuyer et al., 2007) Comment:clustered apical distribution northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Tepass et al., 1990) embryonic stage -- adult stage     (Tepass et al., 1990)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage   stomatogastric nervous system   (Tepass et al., 1990) embryonic/larval trachea   (Tepass et al., 1990) presumptive embryonic/larval peripheral nervous system   (Tepass et al., 1990) ectoderm   (Tepass et al., 1990) chordotonal organ   (Tepass et al., 1990) Malpighian tubule   (Tepass et al., 1990) embryonic stage 8 -- 11   neuroblast   (Tepass et al., 1990) stomodeum   (Tepass et al., 1990) third instar larval stage   optic lobe   (Tepass and Knust, 1990) peripodial epithelium   (Tepass and Knust, 1990) adult stage | male   testicular duct   (Tepass and Knust, 1990) male accessory gland   (Tepass and Knust, 1990) ejaculatory duct   (Tepass and Knust, 1990) immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   optic lobe   (Tepass et al., 1990) embryonic/larval hindgut   (Tepass et al., 1990) epithelial cell   (Tepass et al., 1990) endoderm   (Tepass et al., 1990) embryonic/larval foregut   (Tepass et al., 1990) external sensory organ   (Tepass et al., 1990) embryonic/larval salivary gland   (Tepass et al., 1990) embryonic stage | late   adult salivary gland primordium   • plasma membrane | apical (Myat and Andrew, 2002) embryonic stage 5   epithelial cell   • cytoplasm | apical (Lecuyer et al., 2007) Comment:clustered apical distribution embryonic stage 8 -- 11   posterior embryonic/larval midgut   (Tepass et al., 1990) embryonic stage 11   invaginating stomatogastric nervous system precursor   (Gonzalez-Gaitan and Jackle, 2000) embryonic stage 11 -- 16   embryonic hindgut   (Iwaki et al., 2001) embryonic stage 15   keyhole structure   (Fuss et al., 2001) embryonic stage 15 -- 16   embryonic hindgut   (Fuss et al., 2001) embryonic stage 16   hindgut   (Wu and Lengyel, 1998) embryonic small intestine   (Iwaki et al., 2001) embryonic large intestine   (Iwaki et al., 2001) embryonic rectum   (Iwaki et al., 2001) third instar larval stage   imaginal disc   (Tepass and Knust, 1990) salivary gland imaginal ring   (Tepass and Knust, 1990) embryonic/larval garland cell   (Tepass and Knust, 1990) pupal stage   eye photoreceptor cell stalk | apical   (Nam and Choi, 2003) pharate adult stage   rhabdomere R2   (Karagiosis and Ready, 2004) rhabdomere R4   (Karagiosis and Ready, 2004) rhabdomere R5   (Karagiosis and Ready, 2004) rhabdomere R7   (Karagiosis and Ready, 2004) adult stage | male   seminal vesicle   (Tepass and Knust, 1990) ejaculatory bulb   (Tepass and Knust, 1990) adult stage   photoreceptor cell R1 stalk   (Karagiosis and Ready, 2004) photoreceptor cell R2 stalk   (Karagiosis and Ready, 2004) photoreceptor cell R3 stalk   (Karagiosis and Ready, 2004) photoreceptor cell R4 stalk   (Karagiosis and Ready, 2004) photoreceptor cell R5 stalk   (Karagiosis and Ready, 2004) photoreceptor cell R6 stalk   (Karagiosis and Ready, 2004) photoreceptor cell R7 stalk   (Karagiosis and Ready, 2004) adult stage & oogenesis   follicle cell   (Tepass and Knust, 1990) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   epithelium   • cytoplasm | apical (Lecuyer et al., 2007) embryonic stage 13   tracheal pit   • apical plasma membrane (Klebes and Knust, 2000)
Additional Descriptive Data
	crb protein is first detected during gastrulation in the ectoderm and in the endoderm but not in the mesoderm. It localizes to the apical surfaces of epithelial cells and is preferentially concentrated at the borders between neighboring cells. Between stages 8 and 11 crb protein expression is lost in the posterior midgut, in the cells at the bottom of the stomodeal invagination, and in neuroblasts before they delaminate from the ectoderm. By stage 11, crb protein is restricted to epithelial cells of ectodermal origin and is observed in the foregut, the tracheal system, the salivary glands, the Malpighian tubules, the optic lobes, and the stomatogastric nervous system. Later in embryogenesis, expression is observed in the hindgut epithelium and in external sensory organs and chordotonal organs of the PNS. (Tepass et al., 1990) Protein is observed concentrated in cells undergoing apical constriction during invagination of the salivary gland primordia. (Tepass and Knust, 1990, Myat and Andrew, 2002) The expression of crb protein is used as a marker for the apical surface of the hindgut epithelium. crb protein is detected outlining the lumina of the hidgut and malpighian tubules. crb protein is additionally detected in all ectodermally derived epithelia. (Wu and Lengyel, 1998) In third instar larvae, crb protein is observed in epithelial cells but not adepithelial cells of all imaginal discs. It is also seen in the inner and outer optic lobe anlage, the imaginal ring of the salivary glands, faintly in trachea, and on the surface of garland cells. In adult males, crb protein is observed in the testicular duct, seminal vesicle, male accessory gland, ejaculatory bulb, and ejaculatory duct. In females, it is observed in follicle cells in oogenesis stages S1-S10. (Tepass and Knust, 1990) crb protein localizes to the stalk of the rhabdomere. It is seen in this location from about 50% through pupal development only in rhabdomeres R2, R4, R5 and R7, because R1, R3 and R6 lack stalks at this stage. (Karagiosis and Ready, 2004)
Marker for
	keyhole structure embryonic large intestine tracheal system ectodermally derived epithelia
Subcellular Localization
CV Term	plasma membrane (Tepass and Knust, 1990) plasma membrane | apical (Tepass et al., 1990)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0259685    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0259685 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 06-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0259685 expression level Developmental Stage   Expression Level embryo 00-02hr    2179 embryo 02-04hr    3765 embryo 04-06hr    2232 embryo 06-08hr    3358 embryo 08-10hr    4313 embryo 10-12hr    2727 embryo 12-14hr    3328 embryo 14-16hr    2461 embryo 16-18hr    1572 embryo 18-20hr    1449 embryo 20-22hr    789 embryo 22-24hr    922 larva L1    713 larva L2    859 larva L3 12hr old    579 larva L3 puffstage 1-2    582 larva L3 puffstage 3-6    1269 larva L3 puffstage 7-9    2271 white prepupae new    2032 white prepupae 12hr    1816 white prepupae 24hr    2469 pupae 2d postWPP    2435 pupae 3d postWPP    1344 pupae 4d postWPP    1027 adult male 01day    802 adult male 05day    808 adult male 30day    940 adult female 01day    1633 adult female 05day    1913 adult female 30day    1829 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2179) embryo 02-04hr  (3765) embryo 04-06hr  (2232) embryo 06-08hr  (3358) embryo 08-10hr  (4313) embryo 10-12hr  (2727) embryo 12-14hr  (3328) embryo 14-16hr  (2461) embryo 16-18hr  (1572) embryo 18-20hr  (1449) embryo 20-22hr  (789) embryo 22-24hr  (922) larva L1  (713) larva L2  (859) larva L3 12hr old  (579) larva L3 puffstage 1-2  (582) larva L3 puffstage 3-6  (1269) larva L3 puffstage 7-9  (2271) white prepupae new  (2032) white prepupae 12hr  (1816) white prepupae 24hr  (2469) pupae 2d postWPP  (2435) pupae 3d postWPP  (1344) pupae 4d postWPP  (1027) adult male 01day  (802) adult male 05day  (808) adult male 30day  (940) adult female 01day  (1633) adult female 05day  (1913) adult female 30day  (1829) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2179) embryo 02-04hr  (3765) embryo 04-06hr  (2232) embryo 06-08hr  (3358) embryo 08-10hr  (4313) embryo 10-12hr  (2727) embryo 12-14hr  (3328) embryo 14-16hr  (2461) embryo 16-18hr  (1572) embryo 18-20hr  1449 embryo 20-22hr    789 embryo 22-24hr    922 larva L1    713 larva L2    859 larva L3 12hr old    579 larva L3 puffstage 1-2    582 larva L3 puffstage 3-6    1269 larva L3 puffstage 7-9  (2271) white prepupae new  (2032) white prepupae 12hr  (1816) white prepupae 24hr  (2469) pupae 2d postWPP  (2435) pupae 3d postWPP    1344 pupae 4d postWPP    1027 adult male 01day    802 adult male 05day    808 adult male 30day    940 adult female 01day  (1633) adult female 05day  (1913) adult female 30day  (1829) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2179 embryo 02-04hr    3765 embryo 04-06hr    2232 embryo 06-08hr    3358 embryo 08-10hr    4313 embryo 10-12hr    2727 embryo 12-14hr    3328 embryo 14-16hr    2461 embryo 16-18hr    1572 embryo 18-20hr    1449 embryo 20-22hr    789 embryo 22-24hr    922 larva L1    713 larva L2    859 larva L3 12hr old    579 larva L3 puffstage 1-2    582 larva L3 puffstage 3-6    1269 larva L3 puffstage 7-9    2271 white prepupae new    2032 white prepupae 12hr    1816 white prepupae 24hr    2469 pupae 2d postWPP    2435 pupae 3d postWPP    1344 pupae 4d postWPP    1027 adult male 01day    802 adult male 05day    808 adult male 30day    940 adult female 01day    1633 adult female 05day    1913 adult female 30day    1829 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2179 embryo 02-04hr    3765 embryo 04-06hr    2232 embryo 06-08hr    3358 embryo 08-10hr    4313 embryo 10-12hr    2727 embryo 12-14hr    3328 embryo 14-16hr    2461 embryo 16-18hr    1572 embryo 18-20hr    1449 embryo 20-22hr    789 embryo 22-24hr    922 larva L1    713 larva L2    859 larva L3 12hr old    579 larva L3 puffstage 1-2    582 larva L3 puffstage 3-6    1269 larva L3 puffstage 7-9    2271 white prepupae new    2032 white prepupae 12hr    1816 white prepupae 24hr    2469 pupae 2d postWPP    2435 pupae 3d postWPP    1344 pupae 4d postWPP    1027 adult male 01day    802 adult male 05day    808 adult male 30day    940 adult female 01day    1633 adult female 05day    1913 adult female 30day    1829 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0259685 expression level Developmental Stage   Expression Level embryo 00-02hr    2179 embryo 02-04hr    3765 embryo 04-06hr    2232 embryo 06-08hr    3358 embryo 08-10hr    4313 embryo 10-12hr    2727 embryo 12-14hr    3328 embryo 14-16hr    2461 embryo 16-18hr    1572 embryo 18-20hr    1449 embryo 20-22hr    789 embryo 22-24hr    922 larva L1    713 larva L2    859 larva L3 12hr old    579 larva L3 puffstage 1-2    582 larva L3 puffstage 3-6    1269 larva L3 puffstage 7-9    2271 white prepupae new    2032 white prepupae 12hr    1816 white prepupae 24hr    2469 pupae 2d postWPP    2435 pupae 3d postWPP    1344 pupae 4d postWPP    1027 adult male 01day    802 adult male 05day    808 adult male 30day    940 adult female 01day    1633 adult female 05day    1913 adult female 30day    1829 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2179) embryo 02-04hr  (3765) embryo 04-06hr  (2232) embryo 06-08hr  (3358) embryo 08-10hr  (4313) embryo 10-12hr  (2727) embryo 12-14hr  (3328) embryo 14-16hr  (2461) embryo 16-18hr  (1572) embryo 18-20hr  (1449) embryo 20-22hr  (789) embryo 22-24hr  (922) larva L1  (713) larva L2  (859) larva L3 12hr old  (579) larva L3 puffstage 1-2  (582) larva L3 puffstage 3-6  (1269) larva L3 puffstage 7-9  (2271) white prepupae new  (2032) white prepupae 12hr  (1816) white prepupae 24hr  (2469) pupae 2d postWPP  (2435) pupae 3d postWPP  (1344) pupae 4d postWPP  (1027) adult male 01day  (802) adult male 05day  (808) adult male 30day  (940) adult female 01day  (1633) adult female 05day  (1913) adult female 30day  (1829) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  2179 embryo 02-04hr  (3765) embryo 04-06hr  2232 embryo 06-08hr  (3358) embryo 08-10hr  (4313) embryo 10-12hr  (2727) embryo 12-14hr  (3328) embryo 14-16hr  2461 embryo 16-18hr  1572 embryo 18-20hr  1449 embryo 20-22hr    789 embryo 22-24hr    922 larva L1    713 larva L2    859 larva L3 12hr old    579 larva L3 puffstage 1-2    582 larva L3 puffstage 3-6    1269 larva L3 puffstage 7-9  2271 white prepupae new  2032 white prepupae 12hr  1816 white prepupae 24hr  2469 pupae 2d postWPP  2435 pupae 3d postWPP    1344 pupae 4d postWPP    1027 adult male 01day    802 adult male 05day    808 adult male 30day    940 adult female 01day  1633 adult female 05day  1913 adult female 30day  1829 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2179 embryo 02-04hr    3765 embryo 04-06hr    2232 embryo 06-08hr    3358 embryo 08-10hr    4313 embryo 10-12hr    2727 embryo 12-14hr    3328 embryo 14-16hr    2461 embryo 16-18hr    1572 embryo 18-20hr    1449 embryo 20-22hr    789 embryo 22-24hr    922 larva L1    713 larva L2    859 larva L3 12hr old    579 larva L3 puffstage 1-2    582 larva L3 puffstage 3-6    1269 larva L3 puffstage 7-9    2271 white prepupae new    2032 white prepupae 12hr    1816 white prepupae 24hr    2469 pupae 2d postWPP    2435 pupae 3d postWPP    1344 pupae 4d postWPP    1027 adult male 01day    802 adult male 05day    808 adult male 30day    940 adult female 01day    1633 adult female 05day    1913 adult female 30day    1829 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2179 embryo 02-04hr    3765 embryo 04-06hr    2232 embryo 06-08hr    3358 embryo 08-10hr    4313 embryo 10-12hr    2727 embryo 12-14hr    3328 embryo 14-16hr    2461 embryo 16-18hr    1572 embryo 18-20hr    1449 embryo 20-22hr    789 embryo 22-24hr    922 larva L1    713 larva L2    859 larva L3 12hr old    579 larva L3 puffstage 1-2    582 larva L3 puffstage 3-6    1269 larva L3 puffstage 7-9    2271 white prepupae new    2032 white prepupae 12hr    1816 white prepupae 24hr    2469 pupae 2d postWPP    2435 pupae 3d postWPP    1344 pupae 4d postWPP    1027 adult male 01day    802 adult male 05day    808 adult male 30day    940 adult female 01day    1633 adult female 05day    1913 adult female 30day    1829 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0259685    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0259685 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult crop, larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, larval/adult salivary gland, adult ovary, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0259685 expression level Tissue   Expression Level Larval Central Nervous System    66.525 Larval Midgut    213 Larval Hindgut    318.6 Larval Malpighian Tubules    161.5 Larval Fat Body    38.9 Larval Salivary Gland    284.1 Larval Trachea    540.75 Larval Carcass    261.8 Adult Head    271.5 Adult Eye    452.2 Adult Brain    43.8 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    507.1 Adult Midgut    172.4 Adult Hindgut    325.3 Adult Malpighian Tubules    78.3 Adult Fat Body    40.7 Adult Salivary Gland    359.1 Adult Heart    72.725 Adult VirginFemale Spermatheca    72.3 Adult InseminatedFemale Spermatheca    96.3 Adult Ovary    359.6 Adult Testis    43 Adult Male Accessory Gland    128.8 Adult Carcass    127.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    66.525 Larval Midgut    213 Larval Hindgut    318.6 Larval Malpighian Tubules    161.5 Larval Fat Body    38.9 Larval Salivary Gland    284.1 Larval Trachea  (540.75) Larval Carcass    261.8 Adult Head    271.5 Adult Eye    452.2 Adult Brain    43.8 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop  507.1 Adult Midgut    172.4 Adult Hindgut    325.3 Adult Malpighian Tubules    78.3 Adult Fat Body    40.7 Adult Salivary Gland    359.1 Adult Heart    72.725 Adult VirginFemale Spermatheca    72.3 Adult InseminatedFemale Spermatheca    96.3 Adult Ovary    359.6 Adult Testis    43 Adult Male Accessory Gland    128.8 Adult Carcass    127.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    66.525 Larval Midgut    213 Larval Hindgut    318.6 Larval Malpighian Tubules    161.5 Larval Fat Body    38.9 Larval Salivary Gland    284.1 Larval Trachea    540.75 Larval Carcass    261.8 Adult Head    271.5 Adult Eye    452.2 Adult Brain    43.8 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    507.1 Adult Midgut    172.4 Adult Hindgut    325.3 Adult Malpighian Tubules    78.3 Adult Fat Body    40.7 Adult Salivary Gland    359.1 Adult Heart    72.725 Adult VirginFemale Spermatheca    72.3 Adult InseminatedFemale Spermatheca    96.3 Adult Ovary    359.6 Adult Testis    43 Adult Male Accessory Gland    128.8 Adult Carcass    127.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    66.525 Larval Midgut    213 Larval Hindgut    318.6 Larval Malpighian Tubules    161.5 Larval Fat Body    38.9 Larval Salivary Gland    284.1 Larval Trachea    540.75 Larval Carcass    261.8 Adult Head    271.5 Adult Eye    452.2 Adult Brain    43.8 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    507.1 Adult Midgut    172.4 Adult Hindgut    325.3 Adult Malpighian Tubules    78.3 Adult Fat Body    40.7 Adult Salivary Gland    359.1 Adult Heart    72.725 Adult VirginFemale Spermatheca    72.3 Adult InseminatedFemale Spermatheca    96.3 Adult Ovary    359.6 Adult Testis    43 Adult Male Accessory Gland    128.8 Adult Carcass    127.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0259685 expression level Tissue   Expression Level Larval Central Nervous System    66.525 Larval Midgut    213 Larval Hindgut    318.6 Larval Malpighian Tubules    161.5 Larval Fat Body    38.9 Larval Salivary Gland    284.1 Larval Trachea    540.75 Larval Carcass    261.8 Adult Head    271.5 Adult Eye    452.2 Adult Brain    43.8 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    507.1 Adult Midgut    172.4 Adult Hindgut    325.3 Adult Malpighian Tubules    78.3 Adult Fat Body    40.7 Adult Salivary Gland    359.1 Adult Heart    72.725 Adult VirginFemale Spermatheca    72.3 Adult InseminatedFemale Spermatheca    96.3 Adult Ovary    359.6 Adult Testis    43 Adult Male Accessory Gland    128.8 Adult Carcass    127.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    66.525 Larval Midgut    213 Larval Hindgut    318.6 Larval Malpighian Tubules    161.5 Larval Fat Body    38.9 Larval Salivary Gland    284.1 Larval Trachea  540.75 Larval Carcass    261.8 Adult Head    271.5 Adult Eye    452.2 Adult Brain    43.8 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop  507.1 Adult Midgut    172.4 Adult Hindgut    325.3 Adult Malpighian Tubules    78.3 Adult Fat Body    40.7 Adult Salivary Gland    359.1 Adult Heart    72.725 Adult VirginFemale Spermatheca    72.3 Adult InseminatedFemale Spermatheca    96.3 Adult Ovary    359.6 Adult Testis    43 Adult Male Accessory Gland    128.8 Adult Carcass    127.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    66.525 Larval Midgut    213 Larval Hindgut    318.6 Larval Malpighian Tubules    161.5 Larval Fat Body    38.9 Larval Salivary Gland    284.1 Larval Trachea    540.75 Larval Carcass    261.8 Adult Head    271.5 Adult Eye    452.2 Adult Brain    43.8 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    507.1 Adult Midgut    172.4 Adult Hindgut    325.3 Adult Malpighian Tubules    78.3 Adult Fat Body    40.7 Adult Salivary Gland    359.1 Adult Heart    72.725 Adult VirginFemale Spermatheca    72.3 Adult InseminatedFemale Spermatheca    96.3 Adult Ovary    359.6 Adult Testis    43 Adult Male Accessory Gland    128.8 Adult Carcass    127.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    66.525 Larval Midgut    213 Larval Hindgut    318.6 Larval Malpighian Tubules    161.5 Larval Fat Body    38.9 Larval Salivary Gland    284.1 Larval Trachea    540.75 Larval Carcass    261.8 Adult Head    271.5 Adult Eye    452.2 Adult Brain    43.8 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    507.1 Adult Midgut    172.4 Adult Hindgut    325.3 Adult Malpighian Tubules    78.3 Adult Fat Body    40.7 Adult Salivary Gland    359.1 Adult Heart    72.725 Adult VirginFemale Spermatheca    72.3 Adult InseminatedFemale Spermatheca    96.3 Adult Ovary    359.6 Adult Testis    43 Adult Male Accessory Gland    128.8 Adult Carcass    127.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion no informative data Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    271.5   NA  Eye    452.2   NA  Brain    43.8   66.525  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    507.1   213  Midgut    172.4   318.6  Hindgut    325.3   161.5  Malpighian Tubules    78.3   38.9  Fat Body    40.7   284.1  Salivary Gland    359.1   NA  Heart    72.725   540.75  Trachea    NA   NA  VirginFemale Spermatheca    72.3   NA  InseminatedFemale Spermatheca    96.3   NA  Ovary    359.6   NA  Testis    43   NA  Male Accessory Gland    128.8   261.8  Carcass    127.6 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_30
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259685
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal crbB-82 lethal, with Scer\GAL4332.3 crbScer\UAS.cWa lethal, with Scer\GAL4unspecified crbScer\UAS.cWa lethal (with Df(3R)crb87-4) crbS050911 lethal (with Df(3R)crb87-5) crbS010409 crbS025807b crbS050911 crbS050920 crbS058104 crbS135506 crbS138404 lethal | embryonic stage crbD88-3 lethal | embryonic stage, with Scer\GAL4da.G32 crbintra.Scer\UAS.T:Hsap\MYC crbintra.Scer\UAS crbScer\UAS.cWa lethal | embryonic stage, with Scer\GAL4ptc-559.1 crbintra.Scer\UAS.T:Hsap\MYC crbintra.Scer\UAS crbScer\UAS.cWa lethal | embryonic stage | recessive crb1 crb2 crbunspecified lethal | larval stage | recessive crb07207 crbD88-3 lethal | pupal stage | recessive crbS010409 lethal | recessive crb82-04 crb82-16 crb07207 crb07883b crbD88-4 crbD88-5 crbD88-7 crbD88-9 crbj1B5 crbR7 crbS87-9 crbS010409 crbS025807b crbS050911 crbS050920 crbS058104 crbS135506 semi-lethal | embryonic stage, with Scer\GAL4en-e16E crbT6AT9AS11AS13A.intra.Scer\UAS semi-lethal | recessive crbS138404 viable crbEY06985 crbKI.A.T:Avic\GFP crbKI.B.T:Avic\GFP crbKI.C.T:Avic\GFP viable, with Scer\GAL4pnr-MD237 crbGD14463 Sterility Allele female sterile crb07207 fertile crbEY06985 Other Phenotypes Allele cell polarity defective crb1 crb2 cell polarity defective, with Scer\GAL4en-e16E crbintra.Scer\UAS cell polarity defective, with Scer\GAL4GMR.PF crbintra.Scer\UAS.T:Hsap\MYC cell polarity defective, with Scer\GAL4unspecified crbScer\UAS.cWa cell polarity defective | embryonic stage 16, with Scer\GAL4ct.PB crbintra.Scer\UAS.T:Hsap\MYC cell shape defective, with Scer\GAL4c381 crbScer\UAS.cWa hyperplasia, with Scer\GAL4en-e16E crbintra.Scer\UAS size defective | recessive | somatic clone crbΔFBM visible, with Scer\GAL4en-e16E crbintra.Scer\UAS visible, with Scer\GAL4GMR.PF crbintra.Scer\UAS.T:Hsap\MYC crbintra.Scer\UAS crbIntraY10A.E16A.Scer\UAS.T:Hsap\MYC visible, with Scer\GAL4pnr-MD237 crbGD14463 visible, with Scer\GAL4sev.EP.M crbintra.Scer\UAS visible | cell autonomous | somatic clone crb2 visible | recessive | somatic clone crb82-04 crb82-16 wild-type crb+t33 wild-type, with Scer\GAL4GMR.PF crbIntraY10A.E16A.ΔERLI.Scer\UAS.T:Hsap\MYC Phenotype manifest in Allele adherens junction crb2 adherens junction | embryonic stage 9 crb2 adherens junction | embryonic stage 10 crb2 adherens junction | pupal stage | heat sensitive, with Scer\GAL4hs.PB crbScer\UAS.cWa adherens junction | somatic clone crb2 crbD88-3 amnioserosa crb1 crb2 crbS010409 amnioserosa, with Scer\GAL4332.3 crbScer\UAS.cWa crbintra.Scer\UAS crbintra.Scer\UAS.T:Hsap\MYC amnioserosa, with Scer\GAL4da.G32 crbScer\UAS.cWa crbintra.Scer\UAS amnioserosa, with Scer\GAL4ptc-559.1 crbScer\UAS.cWa crbintra.Scer\UAS crbintra.Scer\UAS.T:Hsap\MYC denticle belt, with Scer\GAL4ptc-559.1 crbScer\UAS.cWa crbintra.Scer\UAS crbintra.Scer\UAS.T:Hsap\MYC dorsal closure embryo crbS010409 crbS025807b crbS025817 crbS025819 crbS050920 dorsal closure embryo, with Scer\GAL4c381 crbScer\UAS.cWa dorsal mesothoracic disc & epithelial cell, with Scer\GAL4en-e16E crbT6DT9D.intra.Scer\UAS crbintra.Scer\UAS dorsal trunk primordium, with Scer\GAL4btl.PS crbScer\UAS.cWa ectoderm crb2 egg | germline clone crb07207 embryo crbunspecified embryo, with Scer\GAL4mat.αTub67C.T:Hsim\VP16 crbintra.Scer\UAS.T:Hsap\MYC embryo | embryonic stage 16, with Scer\GAL4ct.PB crbintra.Scer\UAS.T:Hsap\MYC embryonic/first instar larval cuticle crb2 crbD88-1 crbunspecified embryonic/first instar larval cuticle, with Scer\GAL4332.3 crbScer\UAS.cWa embryonic/first instar larval cuticle, with Scer\GAL4c381 crbScer\UAS.cWa embryonic/first instar larval cuticle, with Scer\GAL4da.G32 crbScer\UAS.cWa crbintra.Scer\UAS embryonic/first instar larval cuticle | ventral crb07207 embryonic/larval esophagus | embryonic stage crb1 embryonic/larval foregut | embryonic stage crbD88-4 crbD88-5 crbD88-7 crbD88-9 crbR7 crbS87-9 embryonic/larval hindgut | embryonic stage crb1 crbD88-4 crbD88-5 crbD88-7 crbD88-9 crbR7 crbS87-9 embryonic/larval pharynx | embryonic stage crb1 embryonic/larval proventriculus | embryonic stage crb1 embryonic/larval salivary gland | embryonic stage crb1 crb2 crbD88-4 crbD88-5 crbD88-7 crbD88-9 crbR7 crbS87-9 embryonic/larval spiracle crbD88-3 embryonic/larval spiracle, with Scer\GAL4ems.HRE crbT6AT9AS11AS13A.intra.Scer\UAS embryonic/larval tracheal system | embryonic stage 17 crb2 crbj1B5 embryonic/larval tracheal system | embryonic stage 17, with Scer\GAL4btl.PS crbGD14463 crbJF02777 embryonic epidermis crb1 crb2 embryonic epidermis, with Scer\GAL4332.3 crbScer\UAS.cWa embryonic epidermis, with Scer\GAL4da.G32 crbIntra16-37.Scer\UAS.T:Rnor\CD2 crbIntraE16A.Scer\UAS.T:Hsap\MYC crbIntraWT.Scer\UAS.T:Rnor\CD2 crbIntraY10A.E16A.Scer\UAS.T:Hsap\MYC crbIntraY10A.Scer\UAS.T:Hsap\MYC crbScer\UAS.cWa crbintra.Scer\UAS.T:Hsap\MYC embryonic hindgut crbS010409 embryonic Malpighian tubule crb1 embryonic Malpighian tubule, with Scer\GAL4ct.PB crbintra.Scer\UAS.T:Hsap\MYC epidermis crbD88-2 crbD88-4 crbD88-5 crbD88-7 crbD88-9 crbR7 crbS87-2 crbS87-9 epidermis, with Scer\GAL4da.G32 crbScer\UAS.cWa crbintra.Scer\UAS crbintra.Scer\UAS.T:Hsap\MYC epidermis, with Scer\GAL4ptc-559.1 crbScer\UAS.cWa crbintra.Scer\UAS crbintra.Scer\UAS.T:Hsap\MYC epithelial cell crb11A2 crbdsRNA.cLa eye, with Scer\GAL4GMR.PF crbIntraY10A.E16A.Scer\UAS.T:Hsap\MYC crbintra.Scer\UAS crbintra.Scer\UAS.T:Hsap\MYC eye, with Scer\GAL4sev.EP.M crbintra.Scer\UAS eye, with Scer\GAL4unspecified crbScer\UAS.cWa eye | somatic clone crb82-04 crb82-16 eye disc, with Scer\GAL4GMR.PF crbintra.Scer\UAS eye disc, with Scer\GAL4unspecified crbScer\UAS.cWa eye photoreceptor cell crb2 eye photoreceptor cell | somatic clone crb2 crbM82-4 eye photoreceptor cell stalk crb2 eye photoreceptor cell stalk, with Scer\GAL4ninaE.PHS crbScer\UAS.cWa crbextra.Scer\UAS crbextraTM.Scer\UAS.T:Avic\GFP eye photoreceptor cell stalk | cell autonomous | somatic clone crb2 eye photoreceptor cell stalk | somatic clone crb2 crbD88-3 crbS87-2 follicle cell | somatic clone crb2 germ band crbS010409 crbS025807b crbS025817 crbS025819 crbS050920 interommatidial bristle, with Scer\GAL4GMR.PF crbintra.Scer\UAS interommatidial bristle, with Scer\GAL4sev.EP.M crbintra.Scer\UAS interommatidial bristle | somatic clone crb2 crb82-04 mesothoracic tergum, with Scer\GAL4pnr-MD237 crbGD14463 ommatidial precursor cluster, with Scer\GAL4GMR.PF crbintra.Scer\UAS ommatidium, with Scer\GAL4GMR.PF crbintra.Scer\UAS ommatidium, with Scer\GAL4sev.EP.M crbintra.Scer\UAS ommatidium | somatic clone crb2 ommatidium | third instar larval stage, with Scer\GAL4GMR.PF crbScer\UAS.cWa crbintra.Scer\UAS.T:Hsap\MYC ovariole | germline clone crb07207 photoreceptor & adherens junction, with Scer\GAL4GMR.PF crbIntraY10A.E16A.Scer\UAS.T:Hsap\MYC crbintra.Scer\UAS.T:Hsap\MYC photoreceptor | third instar larval stage, with Scer\GAL4GMR.PF crbScer\UAS.cWa crbintra.Scer\UAS.T:Hsap\MYC photoreceptor cell R1 | third instar larval stage, with Scer\GAL4GMR.PF crbScer\UAS.cWa crbintra.Scer\UAS.T:Hsap\MYC photoreceptor cell R6 | third instar larval stage, with Scer\GAL4GMR.PF crbScer\UAS.cWa crbintra.Scer\UAS.T:Hsap\MYC posterior crossvein, with Scer\GAL4en-e16E crbT6AT9AS11AS13A.intra.Scer\UAS presumptive embryonic/larval nervous system crb11A2 presumptive embryonic salivary gland, with Scer\GAL4fkh.PH crbScer\UAS.cWa retina | cell autonomous | conditional | somatic clone crb2 rhabdomere | cell autonomous | somatic clone crb2 crbM82-4 rhabdomere | pupal stage | heat sensitive, with Scer\GAL4hs.PB crbScer\UAS.cWa rhabdomere | somatic clone crb2 crbD88-3 crbS87-2 secondary pigment cell, with Scer\GAL4GMR.PF crbintra.Scer\UAS secondary pigment cell | somatic clone crb2 crbS87-2 spiracular chamber crb1 spot adherens junction crb1 crb2 spot adherens junction, with Scer\GAL4da.G32 crbScer\UAS.cWa crbintra.Scer\UAS tendon cell, with Scer\GAL4da.G32 crbScer\UAS.cWa crbintra.Scer\UAS crbintra.Scer\UAS.T:Hsap\MYC tertiary pigment cell, with Scer\GAL4GMR.PF crbintra.Scer\UAS tertiary pigment cell | somatic clone crb2 crbS87-2 trachea crb1 crb2 crbD88-4 crbD88-5 crbD88-7 crbD88-9 crbR7 crbS87-9 ventral nervous system crbunspecified wing, with Scer\GAL4en-e16E crbintra.Scer\UAS wing blade | somatic clone crb82-04 crbΔFBM wing disc | posterior compartment, with Scer\GAL4en-e16E crbintra.Scer\UAS wing disc | somatic clone crb82-04 wing margin | cell autonomous | somatic clone crb2 wing vein | cell autonomous | somatic clone crb2 zonula adherens crb1 crb2 crbD88-1 crbunspecified zonula adherens, with Scer\GAL4da.G32 crbScer\UAS.cWa crbintra.Scer\UAS zonula adherens & photoreceptor | somatic clone crb2
Classical Alleles ( 57 )
For All Classical Alleles Show
Allele of crb Class Mutagen Stocks Known lesion crb2 loss of function allele, amorphic allele - genetic evidence ethyl methanesulfonate 2 -- crbj1B5 P-element activity 2 -- crbKG05098 P-element activity 2 -- crb1 amorphic allele - genetic evidence ethyl methanesulfonate 1 Yes crb07207 P-element activity 1 -- crbc01109 piggyBac transposase 1 -- crbc04784 piggyBac transposase 1 -- crbd02006 P-element activity 1 -- crbe04121 piggyBac transposase 1 -- crbEY06985 P-element activity 1 -- crbf01837 piggyBac transposase 1 -- crbf05973 piggyBac transposase 1 -- crbMB08251 1 -- crbD88-1 amorphic allele - genetic evidence X ray 0 Yes crbD88-4 amorphic allele - genetic evidence X ray 0 Yes crbD88-5 amorphic allele - genetic evidence X ray 0 Yes crbD88-7 amorphic allele - genetic evidence X ray 0 Yes crbD88-9 amorphic allele - genetic evidence X ray 0 Yes crbR7 amorphic allele - genetic evidence X ray 0 Yes crbS87-9 amorphic allele - genetic evidence X ray 0 Yes crb07883b P-element activity 0 -- crb11A2 0 -- crb82-04 ethyl methanesulfonate 0 Yes crb82-16 ethyl methanesulfonate 0 Yes crbB-82 P-element activity 0 -- crbD88-2 hypomorphic allele - genetic evidence X ray 0 -- crbD88-3 hypomorphic allele - genetic evidence X ray 0 -- crbf01852 piggyBac transposase 0 -- crbF89 0 -- crbGX24w- 0 Yes crbKI.A.T:Avic\GFP recombination 0 Yes crbKI.B.T:Avic\GFP recombination 0 Yes crbKI.C.T:Avic\GFP recombination 0 Yes crbKI10.T:Zzzz\EosFP-m recombination FLPase SCEI endonuclease 0 Yes crbKI12.T:Zzzz\EosFP-m recombination FLPase SCEI endonuclease 0 Yes crbKI13.T:Zzzz\EosFP-m recombination FLPase SCEI endonuclease 0 Yes crbKI14.rpr+.T:Zzzz\EosFP-m recombination FLPase SCEI endonuclease 0 Yes crbKI2.T:Zzzz\EosFP-m recombination FLPase SCEI endonuclease 0 Yes crbKI5.T:Zzzz\EosFP-m recombination FLPase SCEI endonuclease 0 Yes crbKI6.T:Zzzz\EosFP-m recombination FLPase SCEI endonuclease 0 Yes crbKI8.T:Zzzz\EosFP-m recombination FLPase SCEI endonuclease 0 Yes crbKI9.rpr+.T:Zzzz\EosFP-m recombination FLPase SCEI endonuclease 0 Yes crbM11.M2 loss of function allele 0 Yes crbM82-4 ethyl methanesulfonate 0 -- crbS010409 hypomorphic allele - genetic evidence Delta2-3 P-element activity 0 Yes crbS025807b Delta2-3 P-element activity 0 -- crbS025817 0 -- crbS025819 0 -- crbS050911 Delta2-3 P-element activity 0 -- crbS050920 Delta2-3 P-element activity 0 -- crbS058104 Delta2-3 P-element activity 0 -- crbS135506 Delta2-3 P-element activity 0 -- crbS138404 Delta2-3 P-element activity 0 -- crbS87-2 hypomorphic allele - genetic evidence X ray 0 -- crbunspecified ethyl methanesulfonate 0 -- crbΔFBM recombination 0 Yes crbΔPBM recombination 0 Yes
Alleles Carried on Transgenic Constructs ( 36 )
For All Alleles Carried on Transgenic Constructs Show
Allele of crb Class Mutagen Stocks Known lesion crbGD14463 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes crbScer\UAS.cWa in vitro construct - regulatory fusion in vitro construct - minigene 2 Yes crbHMS01409 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes crbJF02777 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes crb+t33 in vitro construct - genomic fragment 0 Yes crb1.MtnA in vitro construct - amino acid replacement 0 Yes crb8F105.MtnA.T:VSV\G in vitro construct - deletion 0 Yes crbdsRNA.cLa in vitro construct - RNAi 0 Yes crbextra.Scer\UAS in vitro construct - regulatory fusion 0 Yes crbextraTM.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes crbGD145 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes crbGD2641 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes crbintra.GMR in vitro construct - regulatory fusion 0 Yes crbintra.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion 0 Yes crbintra.Scer\UAS.T:Zzzz\EosFP-m in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes crbintra.Scer\UAS in vitro construct - regulatory fusion 0 Yes crbintra.SV40.3'UTR.Scer\UAS in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes crbIntra1-14.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes crbIntra16-29.Scer\UAS.T:Rnor\CD2 in vitro construct - deletion 0 Yes crbIntra16-37.Scer\UAS.T:Rnor\CD2 in vitro construct - deletion in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes crbIntraE16A.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes crbIntraWT.Scer\UAS.T:Rnor\CD2 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes crbIntraY10A.E16A.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes crbIntraY10A.E16A.ΔERLI.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes crbIntraY10A.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes crbIntraΔERLI.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes crbmEosFP.KI.Scer\SceI.RS in vitro construct 0 Yes crbMtnA.PW in vitro construct - regulatory fusion 0 Yes crbMtnA.T:VSV\G in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes crbR7A.MtnA.T:VSV\G in vitro construct - site directed mutagenesis 0 Yes crbS6.MtnA.T:VSV\G in vitro construct - deletion 0 Yes crbScer\UAS.intra.T:Hsap\MYC in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes crbT6AT9A.intra.Scer\UAS in vitro construct - site directed mutagenesis in vitro construct - regulatory fusion 0 Yes crbT6AT9AS11AS13A.intra.Scer\UAS in vitro construct - site directed mutagenesis in vitro construct - regulatory fusion 0 Yes crbT6DT9D.intra.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes crbY10A.MtnA.T:VSV\G in vitro construct - site directed mutagenesis 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)B204 (Jurgens et al., 1984) Df(3R)BSC317 (Ling et al., 2010) Df(3R)BSC638 (Christensen et al., 2008.10.20) Df(3R)crb87-4 (Szeged Stock Center, 1998-, Spradling, 1999.12.9, BDGP Project Members, 1994-1999, Cobb, 1996) Df(3R)crb87-5 (Szeged Stock Center, 1998-, Spradling et al., 1999, BDGP Project Members, 1994-1999, Cobb, 1996, Deak et al., 1997) Df(3R)Exel6199 (Ryder, 2004.4.26) Df(3R)Exel8178 (Ryder, 2004.4.26, Ling et al., 2010) Ts(YSt;3Lt)H173 (Jurgens et al., 1984, Tearle and Nusslein-Volhard, 1987) Ts(YSt;3Lt)R13 (Jurgens et al., 1984)
Not disrupted in	Df(3R)slo8 (Cobb, 1996) Df(3R)XTA1 (Cobb, 1996) In(3R)Ubx7LLatsR (Cobb, 1996) T(Y;3)A117 (Cobb, 1996) Ts(YLt;3Lt)G73 (Tearle and Nusslein-Volhard, 1987)
Duplicated in	Dp(3;3)M95A+13 (Tepass and Knust, 1993)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD145} NA P{GD2641} NA P{GD14463} NA P{TRiP.HMS01409} NA P{TRiP.JF02777} NA P{UAS-crb.extra.TM-GFP} NA P{UAS-crb.extra} NA P{UAS-crb.Intra1-14} NA P{UAS-crb.Intra16-29-WT.T:CD2} NA P{UAS-crb.Intra16-37-WT.T:CD2} NA P{UAS-crb.intra.mEosFP} NA P{UAS-crb.intra.T6AT9A} NA P{UAS-crb.intra} NA P{UAS-crb.IntraE16A} NA P{UAS-crb.intra-myc} NA P{UAS-crb.IntraWT.T:CD2} NA P{UAS-crb.IntraY10A.E16A.ΔERLI} NA P{UAS-crb.IntraY10A.E16A} NA P{UAS-crb.IntraY10A} NA P{UAS-crb.IntraΔERLI} NA P{UAS-crb.myc} NA P{UAS-crb.SV40.3'UTR} NA P{UAS-crb.wt} NA P{UAS-crb-intra.T6DT9D} NA reporter construct P{crb-lacZ.3n--} No P{crb-lacZ.-4n4n} No P{crb-lacZ.43.2} No P{crb-lacZ.H-Pelican} No P{crb-lacZ.STAT.mut} No characterization construct P{FRT(crb::mEosFP.KI)} NA P{GMR-crb.intra} NA P{Pw-1} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}crbj1B5 No P{lacW}crbS010409 No P{lacW}crbS025807b No P{lacW}crbS025817 No P{lacW}crbS025819 No P{lacW}crbS050911 No P{lacW}crbS050920 No P{lacW}crbS058104 No P{lacW}crbS135506 No P{lacW}crbS138404 No P{lacW}l(3)SH075SH075 No P{PZ}crb07207 No P{PZ}crb07883b No P{PZ}crbB-82 No insertion of mobile activating element P{EP}CG5715EP1089 NA P{EPgy2}crbEY06985 NA P{XP}crbd02006 NA miscellaneous insertions P{SUPor-P}crbKG05098 NA PBac{nub-lacZ.A}crbM11.M2 NA PBac{PB}crbc01109 NA PBac{PB}crbc04784 NA PBac{RB}crbe04121 NA PBac{WH}crbf01837 NA PBac{WH}crbf01852 NA PBac{WH}crbf05973 NA insertion of enhancer trap binary system Mi{ET1}crbMB08251 No
Gene Ontology: Function, Process & Cellular Component ( 43 unique terms )
Terms Based on Experimental Evidence ( 31 terms )
Molecular Function
CV term Evidence References
protein kinase C binding inferred from physical interaction with aPKC (Sotillos et al., 2004)
Biological Process
CV term Evidence References
adherens junction organization inferred from mutant phenotype (Fan et al., 2003) cellular membrane organization inferred from mutant phenotype (Myat and Andrew, 2002) compound eye morphogenesis inferred from genetic interaction with ex (Ling et al., 2010) inferred from genetic interaction with kibra (Ling et al., 2010) inferred from genetic interaction with Mer (Ling et al., 2010) inferred from mutant phenotype (Ling et al., 2010) compound eye photoreceptor development inferred from mutant phenotype (Fan et al., 2003) dorsal closure, amnioserosa morphology change inferred from mutant phenotype (Harden et al., 2002) establishment of epithelial cell apical/basal polarity inferred from direct assay (Campbell et al., 2009) establishment or maintenance of apical/basal cell polarity inferred from mutant phenotype (Lu and Bilder, 2005) establishment or maintenance of cell polarity inferred from mutant phenotype (Tepass et al., 1990) establishment or maintenance of polarity of embryonic epithelium inferred from mutant phenotype (Hong et al., 2001) establishment or maintenance of polarity of follicular epithelium inferred from mutant phenotype (Tanentzapf et al., 2000) liquid clearance, open tracheal system inferred from genetic interaction with crb (Stümpges and Behr, 2011) maintenance of epithelial cell apical/basal polarity inferred from direct assay (Campbell et al., 2009) negative regulation of Notch signaling pathway inferred from genetic interaction with N (Herranz et al., 2006) negative regulation of organ growth inferred from mutant phenotype (Ling et al., 2010) nervous system development inferred from mutant phenotype (Koizumi et al., 2007) oogenesis inferred from mutant phenotype (Perrimon et al., 1996) open tracheal system development inferred from mutant phenotype (Lovegrove et al., 2006) photoreceptor cell maintenance inferred from mutant phenotype (Johnson et al., 2002) positive regulation of cell proliferation inferred from mutant phenotype (Lu and Bilder, 2005) positive regulation of phosphorylation inferred from mutant phenotype (Ling et al., 2010) regulation of hippo signaling cascade inferred from genetic interaction with ex (Ling et al., 2010) inferred from genetic interaction with kibra (Ling et al., 2010) inferred from genetic interaction with Mer (Ling et al., 2010) rhabdomere development inferred from mutant phenotype (Pichaud and Desplan, 2001, Fan et al., 2003) salivary gland morphogenesis inferred from mutant phenotype (Myat and Andrew, 2002) tube morphogenesis inferred from mutant phenotype (Myat and Andrew, 2002) zonula adherens assembly inferred from mutant phenotype (Izaddoost et al., 2002) zonula adherens maintenance inferred from mutant phenotype (Pellikka et al., 2002, Harris and Peifer, 2004)
Cellular Component
CV term Evidence References
apical plasma membrane inferred from direct assay (Tepass and Knust, 1990) apicolateral plasma membrane inferred from direct assay (Sotillos et al., 2004, Bachmann et al., 2001) inferred from physical interaction with sdt (Bachmann et al., 2001) plasma membrane inferred from direct assay (Tanentzapf et al., 2000) rhabdomere inferred from direct assay (Liu et al., 2009)
Terms Based on Predictions or Assertions ( 22 terms )
Molecular Function
CV term Evidence References
calcium ion binding inferred from electronic annotation with InterPro:IPR001881, InterPro:IPR018097 (FlyBase Curators et al., 2004-) spectrin binding traceable author statement (Medina et al., 2002)
Biological Process
CV term Evidence References
cell-cell junction assembly non-traceable author statement (Bilder et al., 2002, Wedlich, 2002) cellular membrane organization traceable author statement (Sudarsan, 2003) compound eye photoreceptor development traceable author statement (Pichaud and Desplan, 2002) establishment of epithelial cell apical/basal polarity traceable author statement (Patthy, 1991) establishment or maintenance of cell polarity non-traceable author statement (Humbert et al., 2003) establishment or maintenance of epithelial cell apical/basal polarity non-traceable author statement (Swiss-Prot Project Members, 1989.3.1) traceable author statement (Tepass et al., 2001) morphogenesis of an epithelium non-traceable author statement (Swiss-Prot Project Members, 1989.3.1, Cereijido et al., 2003) traceable author statement (Tepass et al., 2001) morphogenesis of a polarized epithelium traceable author statement (Gibson and Perrimon, 2003) photoreceptor cell maintenance non-traceable author statement (Driscoll and Gerstbrein, 2003) protein localization traceable author statement (Humbert et al., 2003) rhabdomere development non-traceable author statement (Pichaud and Desplan, 2002) salivary gland development traceable author statement (Sudarsan, 2003, Abrams et al., 2003, Nelson, 2003) zonula adherens assembly traceable author statement (Tepass et al., 2001, Medina et al., 2002, Humbert et al., 2003) zonula adherens maintenance non-traceable author statement (Pichaud and Desplan, 2002)
Cellular Component
CV term Evidence References
apical plasma membrane non-traceable author statement (Hong et al., 2001, Wedlich, 2002) traceable author statement (Patthy, 1991, Tanentzapf et al., 2000, Tepass et al., 2001) cell-cell adherens junction non-traceable author statement (Bilder et al., 2002) integral to membrane non-traceable author statement (Swiss-Prot Project Members, 1989.3.1) traceable author statement (Patthy, 1991, Wedlich, 2002) plasma membrane inferred from sequence or structural similarity (Tepass et al., 1990) inferred from sequence or structural similarity with EMBL:D32210 (FlyBase, 1992-) septate junction traceable author statement (Wedlich, 2002) subapical complex traceable author statement (Medina et al., 2002)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions crb allele Gene References crb1 arm (Greaves et al., 1999) os (Bach et al., 2003) crb2 BacA\p35 (Johnson et al., 2002) CycE (Brumby et al., 2004) dlg1 (Tanentzapf and Tepass, 2003) gkt (Dunlop et al., 2004) kst (Pellikka et al., 2002, Medina et al., 2002) l(2)gl (Tanentzapf and Tepass, 2003) scrib (Tanentzapf and Tepass, 2003) crb11A2 scrib (Bilder et al., 2003) crbintra.Scer\UAS dlg1 (Tanentzapf and Tepass, 2003) l(2)gl (Tanentzapf and Tepass, 2003) scrib (Tanentzapf and Tepass, 2003) crbj1B5 os (Bach et al., 2003) crbS010409 Rac1 (Harden et al., 2002) Sac1 (Wei et al., 2003) unspecified aPKC (Sotillos et al., 2004) sdt (Hong et al., 2001) shg (Greaves et al., 1999)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67824 DroID - A comprehensive database of gene and protein interactions. • FBgn0259685 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42896
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dbuz\crb (Ranz et al., 1999) Dpse\GA19553   Drep\crb (Ranz et al., 1999) Dvir\crb (Ranz et al., 1999)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL009102-PA Aedes aegypti (mosquito) AGAP003873-PA Anopheles gambiae (mosquito) XP_001121416.1 Apis mellifera (honey bee) XP_001950069.1 Acyrthosiphon pisum (pea aphid) 86846 Branchiostoma floridae (lancelet) BGIBMGA007609-PA Bombyx mori (silk worm) CN01205 Caenorhabditis brenneri (small nematode) CBP31620 Caenorhabditis briggsae (nematode) CE07053 Caenorhabditis elegans (worm) ENSCINP00000001113 Ciona intestinalis (sea squirt) JA11912 Caenorhabditis japonica (nematode) CPIJ012979 Culex pipens (mosquito) ENSCPOP00000008998 Cavia porcellus (guinea pig) RP40283 Caenorhabditis remanei (nematode) ENSCSAVP00000006984 Ciona savignyi (sedentary tunicate) DDB0235380 Dictyostelium discoideum (amoeba) 301952 Daphnia pulex (daphnia) ENSDARP00000078748 Danio rerio (zebra fish) ENSGALP00000037962 Gallus gallus (chicken) GL50803_137727 Giardia lamblia (flagellated protozoan) 72015 Hypsipyla robusta (cedar shoot borer) ENSP00000356370 Homo sapiens (human) 27644 Monocosta brevicollis (choanoflagellate) ENSMODP00000015882 Monodelphis domestica (gray opossum) ENSMMUP00000016170 Macaca mulatta (rhesus monkey) ENSMUSP00000060769 Mus musculus (house mouse) 244064 Nematostella vectensis (starlet anemone) XP_001604138.1 Nasonia vitripennis (wasp) ENSORLP00000015845 Oryzias latipes (japanese killifish) 24459 Ostreococcus tauri (green alga) PHUM004130-PA Pediculus humanus (human body louse) ENSPTRP00000046227 Pan troglodytes (chimpanzee) Smp_143300 Schistosoma mansoni (trematode parasite) XP_970640.1 Tribolium castaneum (red flour beetle) ENSTNIP00000019679 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000035880 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000021935 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12437 LH25440 LH10639 LH12262 FBgn0240650 FBgn0224314 FBgn0210899 FBgn0192542 FBgn0181439 JGI_V11_301952 FBgn0079549 FBgn0159442 FBgn0132833 FBgn0126276 FBgn0103579 FBgn0097744 CPIJ012979 BGIBMGA007609 ACYPI002220 GB14525 AGAP003873 AAEL009102 AAEL009093 PB25650 PHUM489120 GLEAN_04424
Stocks & Reagents
Stocks Listed in FlyBase ( 22 )
Bloomington	5544 w*; P{UAS-crb.wt}30.12e 25594 w1118; Mi{ET1}crbMB08251 27697 y1 v1; P{TRiP.JF02777}attP2
Harvard	- P{XP}crbd02006 - PBac{PB}crbc01109 - PBac{PB}crbc04784 - PBac{RB}crbe04121 - PBac{WH}crbf01837 - PBac{WH}crbf05973
Kyoto	108289 w*; P{UAS-crb.wt}30.12e
VDRC	v39177 w1118; P{GD14463}v39177 v39178 w1118; P{GD14463}v39178
	More stocks available...
Genomic Clones ( 1 )
	BACR04E17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 35 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD13435
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD18496 RE05254
Other clones	30000.1 40304 54052 65889 66393 80722 81910 145168 152914 183514 CK01.6D.H11 CK01.51A.D2 CK01.64D.B10 CK01.124D.G12 EC31671 EK010224 EK063145 EK065139 EK094760 EK142701 EK151607 EK178145 EK208407 EK213536 EK217347 EK252829 EK253909 EK256610 EK288514 FGM105D04 FGM228H12 FGM316A06
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0259685 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42896
Antibody Information
	polyclonal (Tepass et al., 1990, Kilic et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: crb CG6383 (Kodira, 1999.11)
Source for database merge of	Source for merge of: crb far (Pichaud, 2008.5.21) Source for merge of: crb l(3)07207 (Read et al., 2005) Source for merge of: crb l(3)j1B5 (Moussian, 2000.12.7) Source for merge of: crb l(3)S050920 (Szeged Stock Center, 1998-) Source for merge of: crb l(3)S058104 (Wei et al., 2003)
Additional comments	Four more alleles discarded by Tubingen.
Other Comments
	crb is required for cell polarity in the tubles only from the time when morphogenetic movements start. (Campbell et al., 2009) The crb 3' UTR is necessary and sufficient for it's apical localization in embryos. (Li et al., 2008) In vivo overexpression experiments reveal the kinase activity of aPKC on crb to be required for epithelial polarity. (Sotillos et al., 2004) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Overexpression of the JM region of the crb gene product recruits adherens junctions to ectopic sites of the photoreceptor cell membrane without causing loss of apicobasal polarity. (Izaddoost et al., 2002) crb is required to inhibit light-induced photoreceptor degeneration. (Johnson et al., 2002) crb is essential for photoreceptor morphogenesis. crb is required to maintain zonula adherens integrity during the rapid apical membrane expansion that builds the rhabdomere. In addition, crb regulates stalk development by stabilizing the membrane-associated spectrin cytoskeleton. (Pellikka et al., 2002) sdt is a partner of crb in the control of epithelial cell polarity in the developing embryo. (Bachmann et al., 2001) sdt interacts with crb to control polarity of epithelia but not neuroblasts. (Hong et al., 2001) crb is required for the formation and maintenance of the follicular epithelium. (Tanentzapf et al., 2000) Mutants exhibit cellular differentiation defects. (Moore et al., 1998) Loss of cell polarity in the epidermal primordium of crb mutant embryos is associated with a failure to establish the zonulae adherentes. These junctions fail to develop when an altered polarity is induced by the overexpression of crb. crb and sdt have different functions during the formation of the zonula adherens. (Grawe et al., 1996) The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation. crb is required for germ cell viability or early oogenesis. (Perrimon et al., 1996) crb and sdt are required for the third step in zonula adherens formation. The marginal zone of the apical membrane may contain a crb- and sdt-dependent retention mechanism for adherens junction material that facilitates zonula adherens formation. (Tepass, 1996) crb is part of the apical membrane and is concentrated in the immediate vicinity of the zonula adherens. (Tepass, 1996) The insertion of crb protein into the plasma memebrane is necessary and sufficient to confer apical character on a membrane domain. crb plays a key role in specifying the apical plasma membrane domain of ectodermal epithelial cells. (Wodarz et al., 1995) Mutations in crb lead to widespread defects in the development of epithelial tissues followed by massive cell death during embryogenesis. Df(3L)W10 can block the massive cell death but the gross morphological defects are not rescued. (White et al., 1994) crb and sdt encode critical components of a pathway that acts at the apical pole of epithelial cells to control their cytoarchitecture. Mosaic experiments suggest that sdt though not crb is required cell autonomously. Double mutant analysis suggests that sdt acts downstream of and is activated by crb. (Tepass and Knust, 1993) Cys poor regions of the proteins encoded by sli and ft are homologous with the laminin A-type modules of the crb protein.The laminin A-type modules of these proteins may participate in the interactions that control morphogenesis. (Patthy, 1992) Four Cys poor regions of crb are distantly related to domains present in the C terminal part of laminin A chains. (Patthy, 1991) The homology with the C terminal part of laminin A chains suggests that the Cys poor regions of crb may be directly involved in interactions organizing epithelia. (Patthy, 1991) The crb gene encodes an integral membrane protein with 30 EGF-like repeats in the extracellular domain. (Tepass et al., 1990) crb may function to establish and/or maintain epithelia cell polarity. (Tepass et al., 1990) Clonal analysis of crb indicates that crb is not cell autonomous in its expression, this suggests that the gene product may act as a diffusable factor and may serve as a signal in a cell-cell communication process. (Tepass and Knust, 1990) crb mutants display many small holes in the cuticle. (Jurgens et al., 1984)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079756 NM_001043286 RefSeq (Proteins) • NP_524480 NP_001036751 DDBJ / EMBL / GenBank • AA439014 AAA28428 AAF56276 AAM49878 ABI31202 AQ026290 AQ073342 AW942272 AY118509 BH809473 CAA28793 CL525925 CZ466902 CZ469513 CZ472564 CZ481877 CZ484322 CZ484323 CZ484341 CZ488604 CZ488605 M33753 X05144 Z71109 Entrez Gene - A searchable database of RefSeq genes. • 42896 UniProtKB/Swiss-Prot • P10040
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • EGF-like calcium-binding, conserved site (IPR018097) EGF-type aspartate/asparagine hydroxylation site (IPR000152) Epidermal growth factor-like, type 3 (IPR000742) Laminin G domain (IPR001791) EGF-like calcium-binding (IPR001881) Epidermal growth factor-like (IPR006210) Concanavalin A-like lectin/glucanase (IPR008985) Laminin G, subdomain 2 (IPR012680) EGF-like region, conserved site (IPR013032) Concanavalin A-like lectin/glucanase, subgroup (IPR013320) EGF (IPR006209) Laminin G, subdomain 1 (IPR012679)
Linkouts
	BioGRID - A database of protein and genetic interactions • 67824 DroID - A comprehensive database of gene and protein interactions. • FBgn0259685 DRSC - Results from RNAi screens. • FBgn0259685 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259685 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0259685 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42896 InParanoid A subset of ortholog calls from InParanoid. • AAEL009102-PA Aedes aegypti (mosquito) AGAP003873-PA Anopheles gambiae (mosquito) XP_001121416.1 Apis mellifera (honey bee) XP_001950069.1 Acyrthosiphon pisum (pea aphid) 86846 Branchiostoma floridae (lancelet) BGIBMGA007609-PA Bombyx mori (silk worm) CN01205 Caenorhabditis brenneri (small nematode) CBP31620 Caenorhabditis briggsae (nematode) CE07053 Caenorhabditis elegans (worm) ENSCINP00000001113 Ciona intestinalis (sea squirt) JA11912 Caenorhabditis japonica (nematode) CPIJ012979 Culex pipens (mosquito) ENSCPOP00000008998 Cavia porcellus (guinea pig) RP40283 Caenorhabditis remanei (nematode) ENSCSAVP00000006984 Ciona savignyi (sedentary tunicate) DDB0235380 Dictyostelium discoideum (amoeba) 301952 Daphnia pulex (daphnia) ENSDARP00000078748 Danio rerio (zebra fish) ENSGALP00000037962 Gallus gallus (chicken) GL50803_137727 Giardia lamblia (flagellated protozoan) 72015 Hypsipyla robusta (cedar shoot borer) ENSP00000356370 Homo sapiens (human) 27644 Monocosta brevicollis (choanoflagellate) ENSMODP00000015882 Monodelphis domestica (gray opossum) ENSMMUP00000016170 Macaca mulatta (rhesus monkey) ENSMUSP00000060769 Mus musculus (house mouse) 244064 Nematostella vectensis (starlet anemone) XP_001604138.1 Nasonia vitripennis (wasp) ENSORLP00000015845 Oryzias latipes (japanese killifish) 24459 Ostreococcus tauri (green alga) PHUM004130-PA Pediculus humanus (human body louse) ENSPTRP00000046227 Pan troglodytes (chimpanzee) Smp_143300 Schistosoma mansoni (trematode parasite) XP_970640.1 Tribolium castaneum (red flour beetle) ENSTNIP00000019679 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000035880 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000021935 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /gene/crumbs.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42896 modMine - Data generated by the modENCODE project. • FBgn0259685 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12437 LH25440 LH10639 LH12262 FBgn0240650 FBgn0224314 FBgn0210899 FBgn0192542 FBgn0181439 JGI_V11_301952 FBgn0079549 FBgn0159442 FBgn0132833 FBgn0126276 FBgn0103579 FBgn0097744 CPIJ012979 BGIBMGA007609 ACYPI002220 GB14525 AGAP003873 AAEL009102 AAEL009093 PB25650 PHUM489120 GLEAN_04424 REDfly - A database of transcriptional regulatory elements. • FBgn0259685
Synonyms & Secondary IDs ( 19 )
Reported As
Symbol Synonym	0509/20 (Deak et al., 1997) 1384/04 (Deak et al., 1997) CG6383 (Mohit et al., 2006, Perkins et al., 2009, Ni et al., 2011.7.19) Crb (Wei et al., 2004, Richard et al., 2006, Pichaud, 2008.5.21, Ng et al., 2006, Le Bivic, 2005, Morrison et al., 2007, Harden et al., 2002, Muschalik et al., 2006, Kerman et al., 2007, Roeth et al., 2007, Abrams et al., 2006, Wei et al., 2005, Beronja et al., 2005, Lu and Bilder, 2005, Schneider et al., 2006, Moberg et al., 2005, Wu et al., 2007, Nam et al., 2008, Laprise et al., 2008, Maruyama et al., 2011, Li et al., 2007, Suzuki and Ohno, 2006, Harris and Peifer, 2007, Tsarouhas et al., 2007, Bayraktar et al., 2006, Leibfried et al., 2008, Bulgakova et al., 2008, Harris and Tepass, 2008, Mirouse et al., 2009, Vincent et al., 2008, Morrison et al., 2008, Widmann and Dahmann, 2009, Martin et al., 2007, Hamaratoglu et al., 2009, Wang et al., 2009, Woolworth et al., 2009, Massarwa et al., 2009, de Velasco et al., 2007, Zhang and Ward, 2009, Kim et al., 2009, Andrew and Baker, 2008, Martinez et al., 2009, Chung et al., 2009, Maurel-Zaffran et al., 2010, Genevet et al., 2009, Duchi et al., 2010, Norum et al., 2010, Warner et al., 2010, Chen et al., 2010, Nelson et al., 2010, Simone and DiNardo, 2010, Bahri et al., 2010, Nilton et al., 2010, Chen et al., 2011, Tikhmyanova et al., 2010, Kaplan and Tolwinski, 2010, Shaik et al., 2011, Colosimo et al., 2010, Gilbert et al., 2011, Zhan et al., 2010) crb (Huang et al., 2008, Pocha et al., 2011, Richardson and Pichaud, 2010, Liebl et al., 2006, Lecuyer et al., 2007, Luschnig et al., 2006, Gilbert et al., 2007, Harris and Peifer, 2004, Myat and Andrew, 2002, Giebel and Wodarz, 2006, Budde, 2005, Mohit et al., 2006, Wang et al., 2006, Sandmann et al., 2007, Kolsch et al., 2007, Harris and Peifer, 2005, D'Costa et al., 2006, Lovegrove et al., 2006, Li et al., 2008, Maeda et al., 2007, Campbell et al., 2010, Nam and Choi, 2006, Georlette et al., 2007, Christensen et al., 2008.10.20, Szafranski and Goode, 2007, Horne-Badovinac and Bilder, 2008, Koizumi et al., 2007, Herranz et al., 2008, Laprise et al., 2006, Denef et al., 2008, Ling et al., 2010, Mirouse et al., 2007, Li et al., 2008, Grzeschik et al., 2007, Wang and Riechmann, 2007, Sotillos et al., 2008, Xu et al., 2008, Blankenship et al., 2007, Kerman et al., 2008, Huang et al., 2009, Herranz et al., 2006, Rivas et al., 2008, Chanana et al., 2009, Jeon and Zinn, 2009, Campbell et al., 2009, Forster et al., 2010, Fan et al., 2003, Gilbert et al., 2009, Roeth et al., 2009, Gilbert et al., 2009, Leong et al., 2009, Laprise et al., 2010, Morais-de-Sá et al., 2010, Grzeschik et al., 2010, Robinson et al., 2010, Franz and Riechmann, 2010, Shao et al., 2010, Walther and Pichaud, 2010, Chen et al., 2009, Chen et al., 2010, Fichelson et al., 2010, Hsouna et al., 2010, Murthy et al., 2010, Bachmann et al., 2008, Garlena et al., 2010, Krahn et al., 2010, Kaplan et al., 2009, Letizia et al., 2011, Richard et al., 2009, Kilic et al., 2010, Stümpges and Behr, 2011) CRB (Wilk et al., 2000, Bassett et al., 1997, Harris and Beckendorf, 2007) Crbs (Fraichard et al., 2006, Tian and Ten Hagen, 2007) crumb (Ip and Gridley, 2002) Crumbs (Wirtz-Peitz and Knoblich, 2006, Yatsenko et al., 2007) CT19912 (Hynes and Zhao, 2000) far (Pichaud, 2008.5.21, ) l(3)07207 (Spradling et al., 1999, Spradling, 1999.12.9, Perrimon et al., 1996, BDGP Project Members, 1994-1999, ) l(3)j1B5 (Spradling et al., 1999, ) l(3)S050920   l(3)S058104
Name Synonym	Crumbs (Lee et al., 2010, Richard et al., 2006, Pocha et al., 2011, Richardson and Pichaud, 2010, Fox et al., 2010, Ng et al., 2006, Humbert et al., 2006, Fraichard et al., 2006, Geisbrecht and Montell, 2002, Xu et al., 2007, Kerman et al., 2007, Thomas et al., 2007, Fehon, 2006, Abrams et al., 2006, Harris and Peifer, 2004, Menon et al., 2005, Solecki et al., 2006, Beronja et al., 2005, Lu and Bilder, 2005, Bulgakova and Knust, 2007, Duchi et al., 2007, Letizia et al., 2007, Tountas and Fortini, 2007, Husain et al., 2006, Langevin et al., 2005, Windler and Bilder, 2008, Nam et al., 2008, Laprise et al., 2008, Li et al., 2008, Harris and Tepass, 2008, Pichaud, 2008.5.21, Li et al., 2007, Staudt et al., 2006, Margolis and Borg, 2005, Nam and Choi, 2006, Huang et al., 2008, Pirraglia et al., 2006, Laprise et al., 2006, Jaekel and Klein, 2006, Denef et al., 2008, Wang and Riechmann, 2007, Banerjee et al., 2008, Sotillos et al., 2008, Kwon et al., 2008, Leibfried et al., 2008, Martinek et al., 2008, Maybeck and Röper, 2009, Harris and Tepass, 2008, Mirouse et al., 2009, Vincent et al., 2008, Morrison et al., 2008, Banyai and Patthy, 2004, Hijazi et al., 2009, Genevet et al., 2009, Wang et al., 2009, Laprise et al., 2009, Ma et al., 2008, Jeon and Zinn, 2009, Massarwa et al., 2009, Campbell et al., 2009, Moyer and Jacobs, 2008, Zhang and Ward, 2009, Roeth et al., 2009, Andrew and Baker, 2008, Liu et al., 2009, Martinez et al., 2009, Leong et al., 2009, Chung et al., 2009, Laprise et al., 2010, Grzeschik et al., 2010, Robinson et al., 2010, Franz and Riechmann, 2010, Jayaram et al., 2008, Fernandes et al., 2010, Norum et al., 2010, Warner et al., 2010, Walther and Pichaud, 2010, Gonzalez-Gaitan and Jackle, 2000, Simone and DiNardo, 2010, Bahri et al., 2010, Nilton et al., 2010, Murthy et al., 2010, Garlena et al., 2010, Letizia et al., 2011, Kempkens et al., 2006, Richard et al., 2009, Kilic et al., 2010, Shaik et al., 2011) crumbs (Tien et al., 2008, Tepass and Harris, 2007, Wiggin et al., 2005, Rivas et al., 2007, Guthridge et al., 2007, Maeda et al., 2007, Horne-Badovinac and Bilder, 2008, Li et al., 2008, Ling et al., 2010, Blankenship et al., 2007, Kerman et al., 2008, Huang et al., 2009, Desai et al., 2009, Herranz et al., 2006, Chanana et al., 2009, den Hollander et al., 2001, Kim et al., 2009, Acharya et al., 2008, Fan et al., 2003, Morais-de-Sá et al., 2010, Shao et al., 2010, Chen et al., 2010, Fichelson et al., 2010, Hsouna et al., 2010, Bachmann et al., 2008, Lee and Thomas, 2011, Kaplan et al., 2009, Gambis et al., 2011) fat rhabdomere (Pichaud, 2008.5.21) fat rhabdomeres (Pichaud and Desplan, 2001) lethal (3) 07207
Secondary FlyBase IDs
	FBgn0000368 FBgn0010919 FBgn0024518 FBgn0028125 FBgn0044351 FBgn0060827 FBgn0086905
References ( 507 )
Generate a list of	All references relating to this gene ( 507 )
List References by type	Research paper  ( 316 ) Supplementary material  ( 10 ) Review  ( 93 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 59 ) FlyBase analysis  ( 1 ) Computer file  ( 5 ) Conference report  ( 2 ) Stock list  ( 1 ) Curated genome annotation  ( 2 ) Protein sequence record  ( 1 ) Automatic genome annotation  ( 1 ) Book  ( 1 ) Interview  ( 1 )
Recent research papers ( 49 )
	Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Chartier et al., 2011, J. Cell Sci. 124(20): 3393--3398 Crumbs controls epithelial integrity by inhibiting Rac1 and PI3K. [FBrf0216454] Chen et al., 2011, PLoS ONE 6(1): e16127 Genetic interaction of centrosomin and bazooka in apical domain regulation in Drosophila photoreceptor. [FBrf0212822] Gambis et al., 2011, Dev. Biol. 351(1): 128--134 Two-color in vivo imaging of photoreceptor apoptosis and development in Drosophila. [FBrf0213000] Gilbert et al., 2011, Dev. Cell 20(5): 700--712 A Screen for Conditional Growth Suppressor Genes Identifies the Drosophila Homolog of HD-PTP as a Regulator of the Oncoprotein Yorkie. [FBrf0213686] Kolahgar et al., 2011, Development 138(14): 3021--3031 Apical deficiency triggers JNK-dependent apoptosis in the embryonic epidermis of Drosophila. [FBrf0214000] League and Nam, 2011, PLoS ONE 6(6): e21218 Role of Kinesin Heavy Chain in Crumbs Localization along the Rhabdomere Elongation in Drosophila Photoreceptor. [FBrf0213997] Lee and Thomas, 2011, Mech. Dev. 128(1-2): 116--128 Rac1 modulation of the apical domain is negatively regulated by β(Heavy)-spectrin. [FBrf0213021] Letizia et al., 2011, J. Cell Sci. 124(2): 240--251 Regulated Crb accumulation controls apical constriction and invagination in Drosophila tracheal cells. [FBrf0212559] Maruyama et al., 2011, PLoS ONE 6(6): e20901 Genome-Wide Analysis Reveals a Major Role in Cell Fate Maintenance and an Unexpected Role in Endoreduplication for the Drosophila FoxA Gene Fork Head. [FBrf0214025] Mui et al., 2011, PLoS ONE 6(10): e25965 Role of spectraplakin in Drosophila photoreceptor morphogenesis. [FBrf0216481] Muschalik and Knust, 2011, J. Cell Sci. 124(21): 3715--3725 Increased levels of the cytoplasmic domain of Crumbs repolarise developing Drosophila photoreceptors. [FBrf0216625] Pocha et al., 2011, Curr. Biol. 21(13): 1111--1117 Retromer controls epithelial cell polarity by trafficking the apical determinant crumbs. [FBrf0214250] Sansores-Garcia et al., 2011, EMBO J. 30(12): 2325--2335 Modulating F-actin organization induces organ growth by affecting the Hippo pathway. [FBrf0213953] Shaik et al., 2011, Glycobiology 21(6): 743--756 The Alg5 ortholog Wollknäuel is essential for correct epidermal differentiation during Drosophila late embryogenesis. [FBrf0214472] Stümpges and Behr, 2011, FEBS Lett. 585(20): 3316--3321 Time-specific regulation of airway clearance by the Drosophila J-domain transmembrane protein Wurst. [FBrf0216409] Bahri et al., 2010, Development 137(12): 2023--2032 The leading edge during dorsal closure as a model for epithelial plasticity: Pak is required for recruitment of the Scribble complex and septate junction formation. [FBrf0210918] Campbell et al., 2010, Mech. Dev. 127(7-8): 345--357 Mesenchymal-to-epithelial transition of intercalating cells in Drosophila renal tubules depends on polarity cues from epithelial neighbours. [FBrf0211143] Chen et al., 2010, PLoS ONE 5(3): e9480 Role of Spastin in Apical Domain Control along the Rhabdomere Elongation in Drosophila Photoreceptor. [FBrf0210148] Chen et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(36): 15810--15815 The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila. [FBrf0211766] Colosimo et al., 2010, Dev. Dyn. 239(1): 115--125 GSK3beta affects apical-basal polarity and cell-cell adhesion by regulating aPKC levels. [FBrf0215313] Duchi et al., 2010, Development 137(9): 1493--1503 Drosophila VHL tumor-suppressor gene regulates epithelial morphogenesis by promoting microtubule and aPKC stability. [FBrf0210606] Fernandes et al., 2010, Dev. Cell 18(1): 64--76 Zona pellucida domain proteins remodel the apical compartment for localized cell shape changes. [FBrf0211093] Fichelson et al., 2010, Development 137(5): 815--824 lethal giant larvae is required with the par genes for the early polarization of the Drosophila oocyte. [FBrf0209930] Fox et al., 2010, J. Cell Biol. 191(3): 479--492 The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity. [FBrf0212217] Franz and Riechmann, 2010, Dev. Biol. 338(2): 136--147 Stepwise polarisation of the Drosophila follicular epithelium. [FBrf0209855] Garlena et al., 2010, J. Cell Sci. 123(18): 3177--3188 Regulation of mixed-lineage kinase activation in JNK-dependent morphogenesis. [FBrf0211702] Grzeschik et al., 2010, Curr. Biol. 20(7): 573--581 Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms. [FBrf0210559] Hsouna et al., 2010, Mol. Cell. Biol. 30(15): 3779--3794 Drosophila von hippel-lindau tumor suppressor gene function in epithelial tubule morphogenesis. [FBrf0211250] Kaplan and Tolwinski, 2010, J. Cell Sci. 123(18): 3157--3165 Spatially defined Dsh-Lgl interaction contributes to directional tissue morphogenesis. [FBrf0211705] Kilic et al., 2010, Europ. J. Cell Biol. 89(6): 449--461 The Drosophila Crumbs signal peptide is unusually long and is a substrate for signal peptide peptidase. [FBrf0210611] Krahn et al., 2010, J. Cell Biol. 190(5): 751--760 Formation of a Bazooka-Stardust complex is essential for plasma membrane polarity in epithelia. [FBrf0211675] Laprise et al., 2010, Curr. Biol. 20(1): 55--61 Epithelial Polarity Proteins Regulate Drosophila Tracheal Tube Size in Parallel to the Luminal Matrix Pathway. [FBrf0209969] Lee et al., 2010, J. Cell Sci. 123(2): 277--285 The cell adhesion molecule Roughest depends on beta(Heavy)-spectrin during eye morphogenesis in Drosophila. [FBrf0209565] Ling et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(23): 10532--10537 The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded. [FBrf0211036] Maurel-Zaffran et al., 2010, Dev. Biol. 343(1-2): 18--27 Reiterative use of signalling pathways controls multiple cellular events during Drosophila posterior spiracle organogenesis. [FBrf0211024] Morais-de-Sá et al., 2010, Cell 141(3): 509--523 aPKC phosphorylation of Bazooka defines the apical/lateral border in Drosophila epithelial cells. [FBrf0210663] Murthy et al., 2010, Development 137(16): 2773--2783 Sec5, a member of the exocyst complex, mediates Drosophila embryo cellularization. [FBrf0211434] Nelson et al., 2010, Genetics 185(3): 831--839 The Drosophila Claudin Kune-kune Is Required for Septate Junction Organization and Tracheal Tube Size Control. [FBrf0211332] Nilton et al., 2010, Development 137(14): 2427--2437 Crooked, coiled and crimpled are three Ly6-like proteins required for proper localization of septate junction components. [FBrf0211147] Norum et al., 2010, PLoS ONE 5(5): e10802 Trafficking through COPII stabilises cell polarity and drives secretion during Drosophila epidermal differentiation. [FBrf0210959] Richardson and Pichaud, 2010, Development 137(4): 641--650 Crumbs is required to achieve proper organ size control during Drosophila head development. [FBrf0209872] Robinson et al., 2010, Curr. Biol. 20(7): 582--590 Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein expanded. [FBrf0210560] Shao et al., 2010, PLoS ONE 5(4): e9938 A modifier screen for Bazooka/PAR-3 interacting genes in the Drosophila embryo epithelium. [FBrf0210449] Simone and DiNardo, 2010, Development 137(8): 1385--1394 Actomyosin contractility and Discs large contribute to junctional conversion in guiding cell alignment within the Drosophila embryonic epithelium. [FBrf0210407] Tikhmyanova et al., 2010, PLoS ONE 5(8): e12369 Dcas supports cell polarization and cell-cell adhesion complexes in development. [FBrf0211678] Walther and Pichaud, 2010, Curr. Biol. 20(12): 1065--1074 Crumbs/DaPKC-Dependent Apical Exclusion of Bazooka Promotes Photoreceptor Polarity Remodeling. [FBrf0211169] Warner et al., 2010, Curr. Biol. 20(8): 677--686 The Cdc42/Par6/aPKC Polarity Complex Regulates Apoptosis-Induced Compensatory Proliferation in Epithelia. [FBrf0211164] Zhan et al., 2010, PLoS ONE 5(11): e14134 The bHLH Transcription Factor, Hairy, Refines the Terminal Cell Fate in the Drosophila Embryonic Trachea. [FBrf0212509] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...