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Gene Dmel\CG42354

General Information
Symbol	Dmel\CG42354	Species	D. melanogaster
Name		Annotation symbol	CG42354
Feature type	protein_coding_gene	FlyBase ID	FBgn0259700
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	CG9216
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	14A9-14A9	Sequence location	X:15,987,092..15,998,945 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG42354 (FBgn0259700). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 7 alleles are reported. No phenotypic data is available. It has 6 annotated transcripts and 6 annotated polypeptides. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during early pupal stages. This gene is annotated by FlyBase as a dicistronic gene, meaning that some or all of its transcripts encode two or more polypeptide-coding open reading frames (ORFs) , with each ORF assigned to a different gene. The distribution of RNA-Seq coverage data amongst the different encoded genes cannot be determined. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system, adult crop, larval midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, adult salivary gland, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval central nervous system, adult midgut, larval fat body, larval salivary gland, larval trachea. Comments on Affy2 ProbeSet: ProbeSet 1630280_s_at aligns to a genomic region shared by exons of 2 FlyBase-annotated genes; hence it is impossible to interpret the expression pattern and levels of CG42353 expression signal. See the GBrowse view of CG42353 to determine the overlapping gene(s). Gene sequence location is X:15987092..15998945.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 14A9-14A9
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG42354 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.42 Gene model reviewed during 5.43 Gene split based on EST/cDNA data. gene_with_dicistronic_mRNA ; SO:0000722
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG42354-RA FBtr0299949  NM_167486   2708   502 CG42354-RB FBtr0299950  NM_001144729   5884   502 CG42354-RC FBtr0299951  NM_001144730   6119   502 CG42354-RD FBtr0310314  NM_001272666   2594   502 CG42354-RE FBtr0310315  NM_001272667   2625   502 CG42354-RF FBtr0310316  NM_001272668   2711   503
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG42354-PA   FBpp0289226   56.7   502   5.91     NP_727937   AAN09385 CG42354-PB   FBpp0289227   56.7   502   5.91     NP_001138201   ACL82933 CG42354-PC   FBpp0289228   56.7   502   5.91     NP_001138202   ACL82934 CG42354-PD   FBpp0301997   56.7   502   5.91     NP_001259595   AGB95437 CG42354-PE   FBpp0301998   56.7   502   5.91     NP_001259596   AGB95438 CG42354-PF   FBpp0301999   56.8   503   5.91     NP_001259597   AGB95439
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202348   AA697640   AA698733   AA698947   AA941906   AA942030   AA951999   AA979110   AE014298 AAN09385   AE014298 ACL82933   AE014298 ACL82934   AE014298 AGB95437   AE014298 AGB95438   AE014298 AGB95439   AI259257   AI260284   AI519052   BG638544   BH256422   BI162811   BI163772   BI164715   BI166827   BI173593   BI229993   BI238351   BI240440   BI241226   BI356516   BI482228   BI485063   BI566996   BI568587   BI578494   BI580425   BI581578   BI582180   BI582508   BI586896   BI605386   BI607813   BI617524   BI617941   BI620820   BI631218   BI631396   BT010113   CA803956   CL610163   CO189145   CO265765   CO267309   CO269127   CO271099   CO272732   CO272907   CO279052   CO287810   CO291519   CO291931   CO292215   CO293567   CO293860   CO294310   CO296306   CO298032   CO298355   CO307281   CO310790   CO314956   CO316907   CO319145   CO319908   CO342366   CZ478480   CZ489184   EC056934   EC058602   EC063961   EC068029   EC072707   EC075056   EC077551   EC089476   EC199162   EC201278   EC201291   EC208608   EC211635   EC213479   EC215936   EC220242   EC232387   EC234191   EC235423   EC236348   EC237485   EC240919   EC241169   EC243780   EC245540   EC246871   EC258358   EC259050   EV587743   EV590391   EV591698   EV595705
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IR21
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system, adult crop, larval midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, adult salivary gland, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval central nervous system, adult midgut, larval fat body, larval salivary gland, larval trachea. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    409.725 Larval Midgut    872 Larval Hindgut    781.6 Larval Malpighian Tubules    990.9 Larval Fat Body    316.1 Larval Salivary Gland    221.2 Larval Trachea    497.075 Larval Carcass    500.975 Adult Head    488.7 Adult Eye    700.6 Adult Brain    758.7 Adult Thoracic-Abdominal Ganglion    782.2 Adult Crop    1039.1 Adult Midgut    454.1 Adult Hindgut    818.4 Adult Malpighian Tubules    650.3 Adult Fat Body    704.5 Adult Salivary Gland    668.6 Adult Heart    588.05 Adult VirginFemale Spermatheca    620 Adult InseminatedFemale Spermatheca    597.4 Adult Ovary    549.1 Adult Testis    85.9 Adult Male Accessory Gland    1511.7 Adult Carcass    594.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    409.725 Larval Midgut  (872) Larval Hindgut  (781.6) Larval Malpighian Tubules  (990.9) Larval Fat Body    316.1 Larval Salivary Gland    221.2 Larval Trachea    497.075 Larval Carcass  500.975 Adult Head    488.7 Adult Eye  (700.6) Adult Brain  (758.7) Adult Thoracic-Abdominal Ganglion  (782.2) Adult Crop  (1039.1) Adult Midgut    454.1 Adult Hindgut  (818.4) Adult Malpighian Tubules  (650.3) Adult Fat Body  (704.5) Adult Salivary Gland  (668.6) Adult Heart  (588.05) Adult VirginFemale Spermatheca  (620) Adult InseminatedFemale Spermatheca  (597.4) Adult Ovary  (549.1) Adult Testis    85.9 Adult Male Accessory Gland  (1511.7) Adult Carcass  (594.7) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    409.725 Larval Midgut    872 Larval Hindgut    781.6 Larval Malpighian Tubules    990.9 Larval Fat Body    316.1 Larval Salivary Gland    221.2 Larval Trachea    497.075 Larval Carcass    500.975 Adult Head    488.7 Adult Eye    700.6 Adult Brain    758.7 Adult Thoracic-Abdominal Ganglion    782.2 Adult Crop  1039.1 Adult Midgut    454.1 Adult Hindgut    818.4 Adult Malpighian Tubules    650.3 Adult Fat Body    704.5 Adult Salivary Gland    668.6 Adult Heart    588.05 Adult VirginFemale Spermatheca    620 Adult InseminatedFemale Spermatheca    597.4 Adult Ovary    549.1 Adult Testis    85.9 Adult Male Accessory Gland  (1511.7) Adult Carcass    594.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    409.725 Larval Midgut    872 Larval Hindgut    781.6 Larval Malpighian Tubules    990.9 Larval Fat Body    316.1 Larval Salivary Gland    221.2 Larval Trachea    497.075 Larval Carcass    500.975 Adult Head    488.7 Adult Eye    700.6 Adult Brain    758.7 Adult Thoracic-Abdominal Ganglion    782.2 Adult Crop    1039.1 Adult Midgut    454.1 Adult Hindgut    818.4 Adult Malpighian Tubules    650.3 Adult Fat Body    704.5 Adult Salivary Gland    668.6 Adult Heart    588.05 Adult VirginFemale Spermatheca    620 Adult InseminatedFemale Spermatheca    597.4 Adult Ovary    549.1 Adult Testis    85.9 Adult Male Accessory Gland    1511.7 Adult Carcass    594.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    409.725 Larval Midgut    872 Larval Hindgut    781.6 Larval Malpighian Tubules    990.9 Larval Fat Body    316.1 Larval Salivary Gland    221.2 Larval Trachea    497.075 Larval Carcass    500.975 Adult Head    488.7 Adult Eye    700.6 Adult Brain    758.7 Adult Thoracic-Abdominal Ganglion    782.2 Adult Crop    1039.1 Adult Midgut    454.1 Adult Hindgut    818.4 Adult Malpighian Tubules    650.3 Adult Fat Body    704.5 Adult Salivary Gland    668.6 Adult Heart    588.05 Adult VirginFemale Spermatheca    620 Adult InseminatedFemale Spermatheca    597.4 Adult Ovary    549.1 Adult Testis    85.9 Adult Male Accessory Gland    1511.7 Adult Carcass    594.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    409.725 Larval Midgut  (872) Larval Hindgut  781.6 Larval Malpighian Tubules  (990.9) Larval Fat Body    316.1 Larval Salivary Gland    221.2 Larval Trachea    497.075 Larval Carcass  500.975 Adult Head    488.7 Adult Eye  700.6 Adult Brain  758.7 Adult Thoracic-Abdominal Ganglion  782.2 Adult Crop  (1039.1) Adult Midgut    454.1 Adult Hindgut  (818.4) Adult Malpighian Tubules  650.3 Adult Fat Body  704.5 Adult Salivary Gland  668.6 Adult Heart  588.05 Adult VirginFemale Spermatheca  620 Adult InseminatedFemale Spermatheca  597.4 Adult Ovary  549.1 Adult Testis    85.9 Adult Male Accessory Gland  (1511.7) Adult Carcass  594.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    409.725 Larval Midgut    872 Larval Hindgut    781.6 Larval Malpighian Tubules    990.9 Larval Fat Body    316.1 Larval Salivary Gland    221.2 Larval Trachea    497.075 Larval Carcass    500.975 Adult Head    488.7 Adult Eye    700.6 Adult Brain    758.7 Adult Thoracic-Abdominal Ganglion    782.2 Adult Crop  1039.1 Adult Midgut    454.1 Adult Hindgut    818.4 Adult Malpighian Tubules    650.3 Adult Fat Body    704.5 Adult Salivary Gland    668.6 Adult Heart    588.05 Adult VirginFemale Spermatheca    620 Adult InseminatedFemale Spermatheca    597.4 Adult Ovary    549.1 Adult Testis    85.9 Adult Male Accessory Gland  1511.7 Adult Carcass    594.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    409.725 Larval Midgut    872 Larval Hindgut    781.6 Larval Malpighian Tubules    990.9 Larval Fat Body    316.1 Larval Salivary Gland    221.2 Larval Trachea    497.075 Larval Carcass    500.975 Adult Head    488.7 Adult Eye    700.6 Adult Brain    758.7 Adult Thoracic-Abdominal Ganglion    782.2 Adult Crop    1039.1 Adult Midgut    454.1 Adult Hindgut    818.4 Adult Malpighian Tubules    650.3 Adult Fat Body    704.5 Adult Salivary Gland    668.6 Adult Heart    588.05 Adult VirginFemale Spermatheca    620 Adult InseminatedFemale Spermatheca    597.4 Adult Ovary    549.1 Adult Testis    85.9 Adult Male Accessory Gland    1511.7 Adult Carcass    594.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    488.7   NA  Eye    700.6   NA  Brain    758.7   409.725  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    782.2   NA  Crop    1039.1   872  Midgut    454.1   781.6  Hindgut    818.4   990.9  Malpighian Tubules    650.3   316.1  Fat Body    704.5   221.2  Salivary Gland    668.6   NA  Heart    588.05   497.075  Trachea    NA   NA  VirginFemale Spermatheca    620   NA  InseminatedFemale Spermatheca    597.4   NA  Ovary    549.1   NA  Testis    85.9   NA  Male Accessory Gland    1511.7   500.975  Carcass    594.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    7 central nervous system, pupae P8    9 head, virgin 1-day female    19 head, virgin 4-day female    19 head, virgin 20-day female    16 head, mated 1-day female    18 head, mated 4-day female    18 head, mated 20-day female    14 head, mated 1-day male    23 head, mated 4-day male    23 head, mated 20-day male    26 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    48 digestive system, 1-day adult    18 digestive system, 4-day adult    21 digestive system, 20-day adult    18 fat body, larvae L3 wandering    5 fat body, white prepupae    8 fat body, pupae P8    6 carcass, larvae L3 wandering    13 carcass, 1-day adult    18 carcass, 4-day adult    19 carcass, 20-day adult    16 ovary, virgin 4-day female    22 ovary, mated 4-day female    19 testis, mated 4-day male    5 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    7 central nervous system, pupae P8    9 head, virgin 1-day female    19 head, virgin 4-day female    19 head, virgin 20-day female    16 head, mated 1-day female    18 head, mated 4-day female    18 head, mated 20-day female    14 head, mated 1-day male    23 head, mated 4-day male    23 head, mated 20-day male  26 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering  (48) digestive system, 1-day adult    18 digestive system, 4-day adult    21 digestive system, 20-day adult    18 fat body, larvae L3 wandering    5 fat body, white prepupae    8 fat body, pupae P8    6 carcass, larvae L3 wandering    13 carcass, 1-day adult    18 carcass, 4-day adult    19 carcass, 20-day adult    16 ovary, virgin 4-day female    22 ovary, mated 4-day female    19 testis, mated 4-day male    5 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    7 central nervous system, pupae P8    9 head, virgin 1-day female    19 head, virgin 4-day female    19 head, virgin 20-day female    16 head, mated 1-day female    18 head, mated 4-day female    18 head, mated 20-day female    14 head, mated 1-day male    23 head, mated 4-day male    23 head, mated 20-day male    26 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    48 digestive system, 1-day adult    18 digestive system, 4-day adult    21 digestive system, 20-day adult    18 fat body, larvae L3 wandering    5 fat body, white prepupae    8 fat body, pupae P8    6 carcass, larvae L3 wandering    13 carcass, 1-day adult    18 carcass, 4-day adult    19 carcass, 20-day adult    16 ovary, virgin 4-day female    22 ovary, mated 4-day female    19 testis, mated 4-day male    5 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    7 central nervous system, pupae P8    9 head, virgin 1-day female    19 head, virgin 4-day female    19 head, virgin 20-day female    16 head, mated 1-day female    18 head, mated 4-day female    18 head, mated 20-day female    14 head, mated 1-day male    23 head, mated 4-day male    23 head, mated 20-day male    26 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    48 digestive system, 1-day adult    18 digestive system, 4-day adult    21 digestive system, 20-day adult    18 fat body, larvae L3 wandering    5 fat body, white prepupae    8 fat body, pupae P8    6 carcass, larvae L3 wandering    13 carcass, 1-day adult    18 carcass, 4-day adult    19 carcass, 20-day adult    16 ovary, virgin 4-day female    22 ovary, mated 4-day female    19 testis, mated 4-day male    5 accessory gland, mated 4-day male    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    7 central nervous system, pupae P8    9 head, virgin 1-day female    19 head, virgin 4-day female    19 head, virgin 20-day female    16 head, mated 1-day female    18 head, mated 4-day female    18 head, mated 20-day female    14 head, mated 1-day male    23 head, mated 4-day male    23 head, mated 20-day male    26 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    48 digestive system, 1-day adult    18 digestive system, 4-day adult    21 digestive system, 20-day adult    18 fat body, larvae L3 wandering    5 fat body, white prepupae    8 fat body, pupae P8    6 carcass, larvae L3 wandering    13 carcass, 1-day adult    18 carcass, 4-day adult    19 carcass, 20-day adult    16 ovary, virgin 4-day female    22 ovary, mated 4-day female    19 testis, mated 4-day male    5 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    7 central nervous system, pupae P8    9 head, virgin 1-day female    19 head, virgin 4-day female    19 head, virgin 20-day female    16 head, mated 1-day female    18 head, mated 4-day female    18 head, mated 20-day female    14 head, mated 1-day male    23 head, mated 4-day male    23 head, mated 20-day male  26 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering  (48) digestive system, 1-day adult    18 digestive system, 4-day adult    21 digestive system, 20-day adult    18 fat body, larvae L3 wandering    5 fat body, white prepupae    8 fat body, pupae P8    6 carcass, larvae L3 wandering    13 carcass, 1-day adult    18 carcass, 4-day adult    19 carcass, 20-day adult    16 ovary, virgin 4-day female    22 ovary, mated 4-day female    19 testis, mated 4-day male    5 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    7 central nervous system, pupae P8    9 head, virgin 1-day female    19 head, virgin 4-day female    19 head, virgin 20-day female    16 head, mated 1-day female    18 head, mated 4-day female    18 head, mated 20-day female    14 head, mated 1-day male    23 head, mated 4-day male    23 head, mated 20-day male    26 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    48 digestive system, 1-day adult    18 digestive system, 4-day adult    21 digestive system, 20-day adult    18 fat body, larvae L3 wandering    5 fat body, white prepupae    8 fat body, pupae P8    6 carcass, larvae L3 wandering    13 carcass, 1-day adult    18 carcass, 4-day adult    19 carcass, 20-day adult    16 ovary, virgin 4-day female    22 ovary, mated 4-day female    19 testis, mated 4-day male    5 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    7 central nervous system, pupae P8    9 head, virgin 1-day female    19 head, virgin 4-day female    19 head, virgin 20-day female    16 head, mated 1-day female    18 head, mated 4-day female    18 head, mated 20-day female    14 head, mated 1-day male    23 head, mated 4-day male    23 head, mated 20-day male    26 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    48 digestive system, 1-day adult    18 digestive system, 4-day adult    21 digestive system, 20-day adult    18 fat body, larvae L3 wandering    5 fat body, white prepupae    8 fat body, pupae P8    6 carcass, larvae L3 wandering    13 carcass, 1-day adult    18 carcass, 4-day adult    19 carcass, 20-day adult    16 ovary, virgin 4-day female    22 ovary, mated 4-day female    19 testis, mated 4-day male    5 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during early pupal stages. This gene is annotated by FlyBase as a dicistronic gene, meaning that some or all of its transcripts encode two or more polypeptide-coding open reading frames (ORFs) , with each ORF assigned to a different gene. The distribution of RNA-Seq coverage data amongst the different encoded genes cannot be determined. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    28 embryo 04-06hr    9 embryo 06-08hr    8 embryo 08-10hr    15 embryo 10-12hr    18 embryo 12-14hr    25 embryo 14-16hr    22 embryo 16-18hr    27 embryo 18-20hr    23 embryo 20-22hr    24 embryo 22-24hr    28 larva L1    10 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9    29 white prepupae new    46 white prepupae 12hr    90 white prepupae 24hr    52 pupae 2d postWPP    35 pupae 3d postWPP    22 pupae 4d postWPP    22 adult male 01day    24 adult male 05day    20 adult male 30day    17 adult female 01day    19 adult female 05day    19 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr  (28) embryo 04-06hr    9 embryo 06-08hr    8 embryo 08-10hr    15 embryo 10-12hr    18 embryo 12-14hr    25 embryo 14-16hr    22 embryo 16-18hr  (27) embryo 18-20hr    23 embryo 20-22hr    24 embryo 22-24hr  (28) larva L1    10 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9  (29) white prepupae new  (46) white prepupae 12hr  (90) white prepupae 24hr  (52) pupae 2d postWPP  (35) pupae 3d postWPP    22 pupae 4d postWPP    22 adult male 01day    24 adult male 05day    20 adult male 30day    17 adult female 01day    19 adult female 05day    19 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    28 embryo 04-06hr    9 embryo 06-08hr    8 embryo 08-10hr    15 embryo 10-12hr    18 embryo 12-14hr    25 embryo 14-16hr    22 embryo 16-18hr    27 embryo 18-20hr    23 embryo 20-22hr    24 embryo 22-24hr    28 larva L1    10 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9    29 white prepupae new    46 white prepupae 12hr    90 white prepupae 24hr    52 pupae 2d postWPP    35 pupae 3d postWPP    22 pupae 4d postWPP    22 adult male 01day    24 adult male 05day    20 adult male 30day    17 adult female 01day    19 adult female 05day    19 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    28 embryo 04-06hr    9 embryo 06-08hr    8 embryo 08-10hr    15 embryo 10-12hr    18 embryo 12-14hr    25 embryo 14-16hr    22 embryo 16-18hr    27 embryo 18-20hr    23 embryo 20-22hr    24 embryo 22-24hr    28 larva L1    10 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9    29 white prepupae new    46 white prepupae 12hr    90 white prepupae 24hr    52 pupae 2d postWPP    35 pupae 3d postWPP    22 pupae 4d postWPP    22 adult male 01day    24 adult male 05day    20 adult male 30day    17 adult female 01day    19 adult female 05day    19 adult female 30day    17 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    28 embryo 04-06hr    9 embryo 06-08hr    8 embryo 08-10hr    15 embryo 10-12hr    18 embryo 12-14hr    25 embryo 14-16hr    22 embryo 16-18hr    27 embryo 18-20hr    23 embryo 20-22hr    24 embryo 22-24hr    28 larva L1    10 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9    29 white prepupae new    46 white prepupae 12hr    90 white prepupae 24hr    52 pupae 2d postWPP    35 pupae 3d postWPP    22 pupae 4d postWPP    22 adult male 01day    24 adult male 05day    20 adult male 30day    17 adult female 01day    19 adult female 05day    19 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr  28 embryo 04-06hr    9 embryo 06-08hr    8 embryo 08-10hr    15 embryo 10-12hr    18 embryo 12-14hr    25 embryo 14-16hr    22 embryo 16-18hr  27 embryo 18-20hr    23 embryo 20-22hr    24 embryo 22-24hr  28 larva L1    10 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9  29 white prepupae new  (46) white prepupae 12hr  (90) white prepupae 24hr  (52) pupae 2d postWPP  (35) pupae 3d postWPP    22 pupae 4d postWPP    22 adult male 01day    24 adult male 05day    20 adult male 30day    17 adult female 01day    19 adult female 05day    19 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    28 embryo 04-06hr    9 embryo 06-08hr    8 embryo 08-10hr    15 embryo 10-12hr    18 embryo 12-14hr    25 embryo 14-16hr    22 embryo 16-18hr    27 embryo 18-20hr    23 embryo 20-22hr    24 embryo 22-24hr    28 larva L1    10 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9    29 white prepupae new    46 white prepupae 12hr    90 white prepupae 24hr    52 pupae 2d postWPP    35 pupae 3d postWPP    22 pupae 4d postWPP    22 adult male 01day    24 adult male 05day    20 adult male 30day    17 adult female 01day    19 adult female 05day    19 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    28 embryo 04-06hr    9 embryo 06-08hr    8 embryo 08-10hr    15 embryo 10-12hr    18 embryo 12-14hr    25 embryo 14-16hr    22 embryo 16-18hr    27 embryo 18-20hr    23 embryo 20-22hr    24 embryo 22-24hr    28 larva L1    10 larva L2    7 larva L3 12hr old    7 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9    29 white prepupae new    46 white prepupae 12hr    90 white prepupae 24hr    52 pupae 2d postWPP    35 pupae 3d postWPP    22 pupae 4d postWPP    22 adult male 01day    24 adult male 05day    20 adult male 30day    17 adult female 01day    19 adult female 05day    19 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    12 embryonic 1182-4H    17 embryonic GM2    22 embryonic Kc167    17 embryonic S1    36 embryonic S3    12 leg disc CME L1    16 wing disc CME-W2    14 wing disc ML-DmD8    16 wing disc ML-DmD9    18 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    12 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    29 ovary fGS/OSS    10 ovary OSC    14 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    12 embryonic 1182-4H    17 embryonic GM2    22 embryonic Kc167    17 embryonic S1  (36) embryonic S3    12 leg disc CME L1    16 wing disc CME-W2    14 wing disc ML-DmD8    16 wing disc ML-DmD9    18 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    12 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2  (29) ovary fGS/OSS    10 ovary OSC    14 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    12 embryonic 1182-4H    17 embryonic GM2    22 embryonic Kc167    17 embryonic S1    36 embryonic S3    12 leg disc CME L1    16 wing disc CME-W2    14 wing disc ML-DmD8    16 wing disc ML-DmD9    18 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    12 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    29 ovary fGS/OSS    10 ovary OSC    14 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    12 embryonic 1182-4H    17 embryonic GM2    22 embryonic Kc167    17 embryonic S1    36 embryonic S3    12 leg disc CME L1    16 wing disc CME-W2    14 wing disc ML-DmD8    16 wing disc ML-DmD9    18 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    12 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    29 ovary fGS/OSS    10 ovary OSC    14 ovary OSS    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    12 embryonic 1182-4H    17 embryonic GM2    22 embryonic Kc167    17 embryonic S1    36 embryonic S3    12 leg disc CME L1    16 wing disc CME-W2    14 wing disc ML-DmD8    16 wing disc ML-DmD9    18 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    12 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    29 ovary fGS/OSS    10 ovary OSC    14 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    12 embryonic 1182-4H    17 embryonic GM2    22 embryonic Kc167    17 embryonic S1  (36) embryonic S3    12 leg disc CME L1    16 wing disc CME-W2    14 wing disc ML-DmD8    16 wing disc ML-DmD9    18 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    12 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2  29 ovary fGS/OSS    10 ovary OSC    14 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    12 embryonic 1182-4H    17 embryonic GM2    22 embryonic Kc167    17 embryonic S1    36 embryonic S3    12 leg disc CME L1    16 wing disc CME-W2    14 wing disc ML-DmD8    16 wing disc ML-DmD9    18 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    12 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    29 ovary fGS/OSS    10 ovary OSC    14 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    12 embryonic 1182-4H    17 embryonic GM2    22 embryonic Kc167    17 embryonic S1    36 embryonic S3    12 leg disc CME L1    16 wing disc CME-W2    14 wing disc ML-DmD8    16 wing disc ML-DmD9    18 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    12 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    29 ovary fGS/OSS    10 ovary OSC    14 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    19 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    19 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    19 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    19 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    19 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    19 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    19 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    19 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_27
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259700 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9216-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of CG42354 Class Mutagen Stocks Known lesion CG42354e00615 1 Yes CG42354f06480 1 Yes CG42354KG01000 1 Yes CG42354MI02514 1 -- CG42354GS1079 0 Yes
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG42354 Class Mutagen Stocks Known lesion CG42354KK110299 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG42354GD14158 0 --
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK110299} NA characterization construct P{GD14158} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}CG42353MI02514 NA P{SUPor-P}CG42353KG01000 NA PBac{RB}CG42353e00615 NA PBac{WH}CG42353f06480 NA insertion of mobile activating element P{GSV1}CG42353GS1079 NA
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	gene_with_dicistronic_mRNA (FlyBase Genome Annotators, 2008) nuclear_gene (FlyBase Genome Annotators, 2008) protein_coding_gene (FlyBase Genome Annotators, 2008)
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG42354 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0259700
Orthologs
OrthoDB Orthologs (7) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6X3HM1 Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6X3HM1)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG42354     Drosophila sechellia   Dsec\GM12979     Drosophila pseudoobscura pseudoobscura   Dpse\GA25123     Drosophila persimilis   Dper\GL15906     Drosophila virilis   Dvir\GJ18557     Drosophila mojavensis   Dmoj\GI10911     Drosophila grimshawi   Dgri\GH12167
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	12971 y1 P{SUPor-P}CG42353KG01000 CG42354KG01000 35994 y1 w* Mi{MIC}CG42353MI02514 CG42354MI02514
Harvard	- PBac{RB}CG42353e00615 - PBac{WH}CG42353f06480
VDRC	v101942 P{KK110299}VIE-260B
Genomic Clones ( 1 )
	BACR03G18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 97 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH03748
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	HL02919 HL05605 HL06013 LD02519 LD26035 LD27241 LD33375 LD38176 LP02633 LP04031 RE02047 RE03271 RE04444 RE07050 RE16544 RE27907 RE34759 RE37284 RE38251 RE42685 RE64886 RE68332 RE72370 RE74618 RH11762 RH19096 RH20132 RH20730 RH27118 RH36818 RH40181 RH47887 RH48430 RH52055 RH60748 RH60953 RH70977
Other clones	9241 9625 19108 37820 46890 48608 58984 69708 70051 71392 73929 74033 76493 82440 99941 118932 149081 162487 176529 214383.40 214505.27 283714 CK01.3D.E11 CK01.32C.D12 CK01.51B.F12 CK01.84A.D12 CK01.123A.G12 CK01.133B.E6 Dmel_neb_011488_0399_2803 Dmel_neb_012494_0674_0517 Dmel_neb_012730_0125_3359 Dmel_neb_014993_0332_1294 EK043154 EK066848 EK093660 EK101951 EK108156 EK108754 EK133360 EK143604 EK149411 EK171150 EK172828 EK197547 EK198822 EK199464 EK203520 EK205007 EK206536 EK213338 EK222526 EK238611 EK254255 EK266135 EK276405 EK281354 EP14564 ESG0111c.B21.1_A01 LD28995
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0259700 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 7354437
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	Source for split of: CG9216 (FlyBase Genome Annotators, 2008) Annotation CG9216 split into CG42353 and CG42354 in release 5.10 of the genome annotation. (FlyBase Genome Annotators, 2008) One or more of the processed transcripts for this gene contain(s) two non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by CG42353 and CG42354. (FlyBase Genome Annotators, 2008)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_167486 NM_001144729 NM_001144730 NM_001272666 NM_001272667 NM_001272668 RefSeq (Proteins) • NP_727937 NP_001138201 NP_001138202 NP_001259595 NP_001259596 NP_001259597 DDBJ / EMBL / GenBank • AA697640 AA698733 AA979110 AAN09385 ACL82933 ACL82934 AGB95437 AGB95438 AGB95439 AI260284 AI519052 BH256422 BI162811 BI163772 BI164715 BI166827 BI173593 BI229993 BI238351 BI240440 BI241226 BI356516 BI482228 BI485063 BI568587 BI578494 BI580425 BI581578 BI582180 BI582508 BI586896 BI605386 BI607813 BI617524 BI617941 BI620820 BI631218 BI631396 CL610163 CO189145 CO265765 CO267309 CO269127 CO271099 CO272732 CO272907 CO279052 CO287810 CO291519 CO291931 CO293567 CO294310 CO298032 CO298355 CO307281 CO310790 CO314956 CO316907 CO319145 CO319908 CO342366 CZ478480 CZ489184 EC056934 EC058602 EC063961 EC068029 EC072707 EC075056 EC077551 EC089476 EC199162 EC201278 EC201291 EC208608 EC211635 EC213479 EC215936 EC220242 EC232387 EC234191 EC235423 EC236348 EC237485 EC240919 EC241169 EC243780 EC245540 EC258358 EC259050 Entrez Gene - A searchable database of RefSeq genes. • 7354437 UniProtKB/TrEMBL • Q8IR21
Other Crossreferences
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0259700 DRSC - Results from RNAi screens. • FBgn0259700 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259700 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9216-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0259700 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 7354437 modMine - Data generated by the modENCODE project. • FBgn0259700
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	CG9216 (Bellen et al., 2004, Keleman et al., 2009.8.5, Kanuka et al., 2005) CG42354 (FlyBase Genome Annotators, 2008)
Name Synonym
Secondary FlyBase IDs
	FBan0009216 FBgn0030726
References ( 10 )
Research paper	Crawford et al., 2012, Cell Death Differ. 19(12): 2040--2048 Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis. [FBrf0220233] Kanuka et al., 2005, Biochim. Biophys. Acta 1726(3): 225--237 Gain-of-function screen identifies a role of the Sec61alpha translocon in Drosophila postmitotic neurotoxicity. [FBrf0189853] Bellen et al., 2004, Genetics 167(2): 761--781 The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. [FBrf0179132]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979]
Personal communication to FlyBase	Bellen, 2011.5.24, set932.xml set932.xml [FBrf0213718] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase Genome Annotators, 2008, Changes affecting gene model number or type in release 5.10 of the annotated D.melanogaster genome. Changes affecting gene model number or type in release 5.10 of the annotated D.melanogaster genome. [FBrf0204955] FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]