FB2020_01, released Feb 12, 2020

Gene: Dmel\DIP-ε

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General Information
Symbol
Dmel\DIP-ε
Species
D. melanogaster
Name
Dpr-interacting protein ε
Annotation Symbol
CG42368
Feature Type
protein_coding_gene
FlyBase ID
FBgn0259714
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Snapshot
Insufficient genetic data for FlyBase to solicit a summary. [Date last reviewed: 2017-07-13]
Other Summaries
Key Links
Genomic Location
Cytogenetic map
Sequence location
2L:6,377,771..6,411,326 [-]
Recombination map

2-19

RefSeq locus
NT_033779 REGION:6377771..6411326
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
-
Predictions / Assertions
-
Summaries
Gene Group (FlyBase)
DPR-INTERACTING PROTEINS -
Dpr-interacting protein (DIP) members belong to the immunoglobulin superfamily and possess three Ig domains. DIPs form a complex interaction network with members of the Defective proboscis extension reponse (Dpr) family. Dprs and DIPs act as neuronal surface labels involved in the specificity of synaptic connections between neurons and their target cells. (Adapted from FBrf0230454).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\DIP-ε or the JBrowse view of Dmel\DIP-ε for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene
nuclear_gene
(FlyBase Genome Annotators, 2008)
protein_coding_gene
(FlyBase Genome Annotators, 2008)
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
DIP-ε-RA
FBtr0299967
NM_001144327
3150
467
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
DIP-ε-PA
FBpp0289244
51.1
467
7.94
NP_001137799
ACL83005
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\DIP-ε using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (3 terms)
Molecular Function (0 terms)
There is no information supporting a Molecular Function term for this gene. (Based on a review of available data on: 2009-02-19 )
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
synapse organization
inferred from expression pattern
(Carrillo et al., 2015)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
integral component of plasma membrane
inferred from sequence model
(Ozkan et al., 2013)
neuron projection
inferred from biological aspect of ancestor with PANTHER:PTN000456776
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\DIP-ε in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 9 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of DIP-ε
Transgenic constructs containing regulatory region of DIP-ε
Deletions and Duplications ( 1 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Other Phenotypes
Allele
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
mesothoracic tergum, with Scer\GAL4pnr-MD237
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (17)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\LSAMP
5 of 15
Yes
No
Hsap\NTM
5 of 15
Yes
No
Hsap\OPCML
5 of 15
Yes
No
Hsap\IGLON5
4 of 15
No
No
Hsap\NEGR1
4 of 15
No
No
 
Hsap\IGSF9B
2 of 15
No
No
Hsap\KIRREL1
1 of 15
No
No
Hsap\KIRREL2
1 of 15
No
No
Hsap\KIRREL3
1 of 15
No
No
Hsap\LRIT1
1 of 15
No
No
Hsap\LRIT3
1 of 15
No
No
Hsap\NCAM1
1 of 15
No
No
 
Hsap\NCAM2
1 of 15
No
No
Hsap\PAPLN
1 of 15
No
No
Hsap\SDK1
1 of 15
No
No
Hsap\TMIGD1
1 of 15
No
Yes
Hsap\USH2A
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (18)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Lsamp
5 of 15
Yes
No
Mmus\Ntm
5 of 15
Yes
No
Mmus\Iglon5
4 of 15
No
No
Mmus\Negr1
4 of 15
No
No
Mmus\Opcml
4 of 15
No
No
Mmus\Igsf9b
2 of 15
No
No
Mmus\Kirrel2
1 of 15
No
No
 
Mmus\Kirrel3
1 of 15
No
No
 
Mmus\Kirrel
1 of 15
No
No
 
Mmus\Lrit1
1 of 15
No
No
Mmus\Lrit3
1 of 15
No
No
Mmus\Ncam1
1 of 15
No
No
Mmus\Ncam2
1 of 15
No
No
Mmus\Papln
1 of 15
No
No
Mmus\Ptprq
1 of 15
No
Yes
Mmus\Sdk1
1 of 15
No
No
Mmus\Tmigd1
1 of 15
No
Yes
Mmus\Vsig10
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (15)
Rnor\Iglon5
4 of 13
Yes
No
Rnor\Lsamp
4 of 13
Yes
No
Rnor\Negr1
4 of 13
Yes
No
Rnor\Ntm
4 of 13
Yes
No
Rnor\Opcml
4 of 13
Yes
No
Rnor\Igsf9b
2 of 13
No
No
Rnor\Igsf9
1 of 13
No
No
Rnor\Kirrel1
1 of 13
No
No
Rnor\Kirrel2
1 of 13
No
No
Rnor\Kirrel3
1 of 13
No
No
Rnor\Lrit1
1 of 13
No
No
Rnor\Ncam1
1 of 13
No
No
Rnor\Ncam2
1 of 13
No
No
Rnor\Tmigd1
1 of 13
No
Yes
Rnor\Vsig10
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (9)
Xtro\ntm
3 of 12
Yes
Yes
Xtro\iglon5
2 of 12
No
No
Xtro\lsamp
2 of 12
No
No
Xtro\negr1
2 of 12
No
No
Xtro\igsf9b
1 of 12
No
No
Xtro\kirrel2
1 of 12
No
No
Xtro\lrit3
1 of 12
No
Yes
Xtro\opcml
1 of 12
No
No
Xtro\papln
1 of 12
No
No
Danio rerio (Zebrafish) (33)
Drer\negr1
4 of 15
Yes
No
Drer\zgc:110372
4 of 15
Yes
Yes
Drer\ntm
3 of 15
No
No
Drer\igsf9bb
2 of 15
No
No
Drer\lsamp
2 of 15
No
No
Drer\ncam1b
2 of 15
No
No
Drer\olfml2ba
2 of 15
No
No
Drer\opcml
2 of 15
No
No
Drer\dscama
1 of 15
No
No
Drer\dscamb
1 of 15
No
No
Drer\igsf9a
1 of 15
No
No
Drer\itgb4
1 of 15
No
No
Drer\kirrel1a
1 of 15
No
No
Drer\kirrel1b
1 of 15
No
No
Drer\kirrel3a
1 of 15
No
No
Drer\kirrel3b
1 of 15
No
No
Drer\kirrel3l
1 of 15
No
No
Drer\LOC100151468
1 of 15
No
Yes
Drer\lrit1a
1 of 15
No
No
Drer\lrit1b
1 of 15
No
No
Drer\lrit3a
1 of 15
No
No
Drer\lrit3b
1 of 15
No
No
Drer\ncam2
1 of 15
No
No
Drer\paplna
1 of 15
No
No
Drer\pigrl4.2
1 of 15
No
Yes
Drer\sdk1a
1 of 15
No
No
Drer\sdk1b
1 of 15
No
No
Drer\si:ch211-9d9.7
1 of 15
No
Yes
Drer\si:ch211-215e19.3
1 of 15
No
Yes
Drer\si:ch1073-459j12.1
1 of 15
No
No
Drer\ush2a
1 of 15
No
Yes
Drer\vsig10
1 of 15
No
Yes
Drer\zgc:152904
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (7)
Cele\rig-5
7 of 15
Yes
No
Cele\C53A5.13
1 of 15
No
Yes
Cele\rig-3
1 of 15
No
Yes
Cele\unc-122
1 of 15
No
No
Cele\zig-1
1 of 15
No
Yes
Cele\zig-7
1 of 15
No
Yes
Cele\zig-11
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091907D2 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\DIP-ε
Drosophila simulans
Dsim\GD22581
Drosophila erecta
Dere\GG23628
Drosophila yakuba
Dyak\GE18447
Drosophila ananassae
Dana\GF15393
Drosophila pseudoobscura pseudoobscura
Dpse\GA28099
Drosophila willistoni
Dwil\GK15358
Drosophila virilis
Dvir\GJ15194
Drosophila mojavensis
Dmoj\GI17503
Drosophila grimshawi
Dgri\GH10989
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150FQ3 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17025203
Musca domestica
House fly
Mdoa\17005889
Glossina morsitans
Tsetse fly
Gmor\GMOY005765
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_13247
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_13246
Mayetiola destructor
Hessian fly
Mdes\Mdes006902
Mayetiola destructor
Hessian fly
Mdes\Mdes006901
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL004992
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL000576
Anopheles darlingi
American malaria mosquito
Adar\ADAC006874
Anopheles darlingi
American malaria mosquito
Adar\ADAC010341
Anopheles gambiae
Malaria mosquito
Agam\AGAP009965
Anopheles gambiae
Malaria mosquito
Agam\AGAP009964
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ014491
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ014494
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0NZP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA012749
Bombyx mori
Silkmoth
Bmor\BGIBMGA003448
Bombyx mori
Silkmoth
Bmor\BGIBMGA006527
Bombyx mori
Silkmoth
Bmor\BGIBMGA006372
Bombyx mori
Silkmoth
Bmor\BGIBMGA006522
Bombyx mori
Silkmoth
Bmor\BGIBMGA006503
Bombyx mori
Silkmoth
Bmor\BGIBMGA012748
Bombyx mori
Silkmoth
Bmor\BGIBMGA001598
Bombyx mori
Silkmoth
Bmor\BGIBMGA003750
Bombyx mori
Silkmoth
Bmor\BGIBMGA003749
Bombyx mori
Silkmoth
Bmor\BGIBMGA003732
Bombyx mori
Silkmoth
Bmor\BGIBMGA003449
Bombyx mori
Silkmoth
Bmor\BGIBMGA006354
Bombyx mori
Silkmoth
Bmor\BGIBMGA012552
Danaus plexippus
Monarch butterfly
Dple\DPOGS202145-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS203828-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS211022-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS208144-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS201275-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS203651-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS203652-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS205961-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS207613-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS210945-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS210000-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS203849-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL011813
Heliconius melpomene
Postman butterfly
Hmel\HMEL013350
Heliconius melpomene
Postman butterfly
Hmel\HMEL012261
Heliconius melpomene
Postman butterfly
Hmel\HMEL003035
Heliconius melpomene
Postman butterfly
Hmel\HMEL006925
Heliconius melpomene
Postman butterfly
Hmel\HMEL008575
Heliconius melpomene
Postman butterfly
Hmel\HMEL006927
Heliconius melpomene
Postman butterfly
Hmel\HMEL017174
Heliconius melpomene
Postman butterfly
Hmel\HMEL005965
Heliconius melpomene
Postman butterfly
Hmel\HMEL006332
Heliconius melpomene
Postman butterfly
Hmel\HMEL006539
Heliconius melpomene
Postman butterfly
Hmel\HMEL010534
Apis florea
Little honeybee
Aflo\2591117684
Apis florea
Little honeybee
Aflo\3462472596
Apis florea
Little honeybee
Aflo\2843829908
Apis florea
Little honeybee
Aflo\4176508772
Apis florea
Little honeybee
Aflo\2147486513
Apis florea
Little honeybee
Aflo\2147545235
Apis florea
Little honeybee
Aflo\2417181078
Apis florea
Little honeybee
Aflo\5201999796
Apis florea
Little honeybee
Aflo\4646252996
Apis florea
Little honeybee
Aflo\3362862196
Apis florea
Little honeybee
Aflo\4889524388
Apis florea
Little honeybee
Aflo\3918565844
Apis mellifera
Western honey bee
Amel\GB52504
Apis mellifera
Western honey bee
Amel\GB53265
Apis mellifera
Western honey bee
Amel\GB50800
Apis mellifera
Western honey bee
Amel\GB47354
Apis mellifera
Western honey bee
Amel\GB41403
Apis mellifera
Western honey bee
Amel\GB49508
Apis mellifera
Western honey bee
Amel\GB51594
Apis mellifera
Western honey bee
Amel\GB51681
Apis mellifera
Western honey bee
Amel\GB53840
Apis mellifera
Western honey bee
Amel\GB51595
Apis mellifera
Western honey bee
Amel\GB45988
Apis mellifera
Western honey bee
Amel\GB41562
Apis mellifera
Western honey bee
Amel\GB55549
Apis mellifera
Western honey bee
Amel\GB51141
Apis mellifera
Western honey bee
Amel\GB54005
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP16423
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25515
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP23850
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP10259
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP13226
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP13337
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18178
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22308
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP16909
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25516
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP17480
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP13338
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP15373
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22307
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP24236
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP24756
Bombus terrestris
Buff-tailed bumblebee
Bter\15212940
Bombus terrestris
Buff-tailed bumblebee
Bter\15217068
Bombus terrestris
Buff-tailed bumblebee
Bter\15204621
Bombus terrestris
Buff-tailed bumblebee
Bter\15209177
Bombus terrestris
Buff-tailed bumblebee
Bter\15202391
Bombus terrestris
Buff-tailed bumblebee
Bter\15202476
Bombus terrestris
Buff-tailed bumblebee
Bter\15201809
Bombus terrestris
Buff-tailed bumblebee
Bter\15214843
Bombus terrestris
Buff-tailed bumblebee
Bter\15212862
Bombus terrestris
Buff-tailed bumblebee
Bter\15206560
Bombus terrestris
Buff-tailed bumblebee
Bter\15217116
Bombus terrestris
Buff-tailed bumblebee
Bter\15206561
Bombus terrestris
Buff-tailed bumblebee
Bter\15210263
Linepithema humile
Argentine ant
Lhum\LH13292
Linepithema humile
Argentine ant
Lhum\LH18572
Linepithema humile
Argentine ant
Lhum\LH15936
Linepithema humile
Argentine ant
Lhum\LH14263
Linepithema humile
Argentine ant
Lhum\LH10846
Linepithema humile
Argentine ant
Lhum\LH16487
Linepithema humile
Argentine ant
Lhum\LH14183
Linepithema humile
Argentine ant
Lhum\LH25028
Linepithema humile
Argentine ant
Lhum\LH14743
Linepithema humile
Argentine ant
Lhum\LH14746
Linepithema humile
Argentine ant
Lhum\LH14260
Linepithema humile
Argentine ant
Lhum\LH16488
Linepithema humile
Argentine ant
Lhum\LH12878
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001593
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001aa1
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0009c3
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000b0d
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0008a5
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0009c2
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001592
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0007ff
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000cf2
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001a9f
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00084f
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0008c1
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000b8b
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG026202
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG037169
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG015414
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG009362
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005530
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG007875
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG002618
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008148
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG011813
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG013057
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012719
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005528
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05063
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08512
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05966
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09311
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03321
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02178
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02490
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02494
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09361
Tribolium castaneum
Red flour beetle
Tcas\TC000701
Tribolium castaneum
Red flour beetle
Tcas\TC031539
Tribolium castaneum
Red flour beetle
Tcas\TC010786
Tribolium castaneum
Red flour beetle
Tcas\TC031541
Tribolium castaneum
Red flour beetle
Tcas\TC004955
Tribolium castaneum
Red flour beetle
Tcas\TC014162
Tribolium castaneum
Red flour beetle
Tcas\TC000863
Tribolium castaneum
Red flour beetle
Tcas\TC004958
Tribolium castaneum
Red flour beetle
Tcas\TC004659
Tribolium castaneum
Red flour beetle
Tcas\TC032089
Tribolium castaneum
Red flour beetle
Tcas\TC000861
Pediculus humanus
Human body louse
Phum\PHUM036550
Pediculus humanus
Human body louse
Phum\PHUM217590
Pediculus humanus
Human body louse
Phum\PHUM390430
Pediculus humanus
Human body louse
Phum\PHUM126440
Pediculus humanus
Human body louse
Phum\PHUM177710
Pediculus humanus
Human body louse
Phum\PHUM522020
Pediculus humanus
Human body louse
Phum\PHUM578400
Pediculus humanus
Human body louse
Phum\PHUM530320
Pediculus humanus
Human body louse
Phum\PHUM370250
Pediculus humanus
Human body louse
Phum\PHUM007330
Rhodnius prolixus
Kissing bug
Rpro\RPRC005674
Rhodnius prolixus
Kissing bug
Rpro\RPRC015144
Rhodnius prolixus
Kissing bug
Rpro\RPRC009299
Rhodnius prolixus
Kissing bug
Rpro\RPRC006606
Rhodnius prolixus
Kissing bug
Rpro\RPRC001556
Rhodnius prolixus
Kissing bug
Rpro\RPRC010148
Rhodnius prolixus
Kissing bug
Rpro\RPRC011344
Rhodnius prolixus
Kissing bug
Rpro\RPRC005451
Cimex lectularius
Bed bug
Clec\CLEC008941
Cimex lectularius
Bed bug
Clec\CLEC006594
Cimex lectularius
Bed bug
Clec\CLEC000939
Cimex lectularius
Bed bug
Clec\CLEC002212
Cimex lectularius
Bed bug
Clec\CLEC013031
Cimex lectularius
Bed bug
Clec\CLEC011490
Cimex lectularius
Bed bug
Clec\CLEC008000
Cimex lectularius
Bed bug
Clec\CLEC008004
Cimex lectularius
Bed bug
Clec\CLEC002289
Cimex lectularius
Bed bug
Clec\CLEC007082
Cimex lectularius
Bed bug
Clec\CLEC008002
Cimex lectularius
Bed bug
Clec\CLEC011053
Cimex lectularius
Bed bug
Clec\CLEC002287
Cimex lectularius
Bed bug
Clec\CLEC000938
Cimex lectularius
Bed bug
Clec\CLEC002213
Cimex lectularius
Bed bug
Clec\CLEC013034
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI066930
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007740
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI084924
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007560
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI44419
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003036
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005927
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI20922
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI086108
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006654
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003948
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009056
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005486
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009100
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI071368
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_16659
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_17391
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_00542
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_09457
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_17390
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_14804
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_18213
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_14803
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_15537
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_16658
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0O9L )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR015630
Strigamia maritima
European centipede
Smar\SMAR014186
Strigamia maritima
European centipede
Smar\SMAR006796
Strigamia maritima
European centipede
Smar\SMAR009513
Strigamia maritima
European centipede
Smar\SMAR005081
Strigamia maritima
European centipede
Smar\SMAR012070
Strigamia maritima
European centipede
Smar\SMAR005545
Strigamia maritima
European centipede
Smar\SMAR001043
Ixodes scapularis
Black-legged tick
Isca\ISCW023683
Ixodes scapularis
Black-legged tick
Isca\ISCW009561
Ixodes scapularis
Black-legged tick
Isca\ISCW014380
Ixodes scapularis
Black-legged tick
Isca\ISCW023663
Ixodes scapularis
Black-legged tick
Isca\ISCW009560
Ixodes scapularis
Black-legged tick
Isca\ISCW023682
Stegodyphus mimosarum
African social velvet spider
Smim\KFM77193.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM65868.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM76454.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM76455.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM82641.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM68181.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM65269.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM60731.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM66590.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM62082.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur40g00390
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g12070
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g01420
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g09120
Tetranychus urticae
Two-spotted spider mite
Turt\tetur23g00020
Tetranychus urticae
Two-spotted spider mite
Turt\tetur23g00030
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_65516
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_324470
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_40896
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_311160
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_327264
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_54679
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_326104
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_117315
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_335708
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_323113
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G138W )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Negr1L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Fn3/Igf_33
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Fn3/Igf_13
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hypp_2901
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Fn3/Igf_7
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_013493gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hmcn1L_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hypp_1414
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (38)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
DIP-θ
6 of 10
DIP-ζ
6 of 10
Ama
5 of 10
DIP-α
5 of 10
DIP-δ
5 of 10
DIP-η
5 of 10
DIP-ι
5 of 10
DIP-κ
5 of 10
DIP-β
4 of 10
DIP-γ
4 of 10
Lac
4 of 10
DIP-λ
3 of 10
CG7166
2 of 10
CG34353
2 of 10
babos
1 of 10
CG6867
1 of 10
CG13506
1 of 10
CG33543
1 of 10
dpr2
1 of 10
dpr3
1 of 10
dpr5
1 of 10
dpr10
1 of 10
dpr11
1 of 10
dpr15
1 of 10
dpr17
1 of 10
dpr19
1 of 10
dpr21
1 of 10
Dscam2
1 of 10
fipi
1 of 10
kirre
1 of 10
klg
1 of 10
Nrg
1 of 10
robo1
1 of 10
robo2
1 of 10
rst
1 of 10
Strn-Mlck
1 of 10
tutl
1 of 10
wrapper
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    OPCML; opioid binding protein/cell adhesion molecule like
    model of  ovarian cancer
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    LSAMP; limbic system associated membrane protein
    5 of 15
    603241
        NTM; neurotrimin
        5 of 15
        607938
            OPCML; opioid binding protein/cell adhesion molecule like
            5 of 15
            600632
            IGLON5; IgLON family member 5
            4 of 15
                NEGR1; neuronal growth regulator 1
                4 of 15
                613173
                     
                    Functional Complementation Data
                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                    Interactions
                    Summary of Physical Interactions
                    esyN Network Diagram
                    Show neighbor-neighbor interactions:
                    Select Layout:
                    Legend:
                    Protein
                    RNA
                    Selected Interactor(s)
                    Interactions Browser
                    View in Interactions Browser
                    Please see the Physical Interaction reports below for full details
                    protein-protein
                    Physical Interaction
                    Assay
                    References
                    DIP-ε - cDIP
                    enzyme linked immunosorbent assay
                    (Carrillo et al., 2015, Ozkan et al., 2013)
                    DIP-ε - dpr13
                    enzyme linked immunosorbent assay, surface plasmon resonance, predetermined participant
                    (Cosmanescu et al., 2018, Carrillo et al., 2015, Ozkan et al., 2013)
                    DIP-ε - dpr14
                    enzyme linked immunosorbent assay, surface plasmon resonance, predetermined participant
                    (Cosmanescu et al., 2018, Carrillo et al., 2015, Ozkan et al., 2013)
                    DIP-ε - dpr16
                    enzyme linked immunosorbent assay
                    (Carrillo et al., 2015, Ozkan et al., 2013)
                    DIP-ε - dpr17
                    enzyme linked immunosorbent assay
                    (Carrillo et al., 2015, Ozkan et al., 2013)
                    DIP-ε - dpr18
                    surface plasmon resonance, predetermined participant
                    (Cosmanescu et al., 2018)
                    DIP-ε - dpr19
                    enzyme linked immunosorbent assay, surface plasmon resonance, predetermined participant
                    (Cosmanescu et al., 2018, Carrillo et al., 2015, Ozkan et al., 2013)
                    DIP-ε - dpr20
                    enzyme linked immunosorbent assay, surface plasmon resonance, predetermined participant
                    (Cosmanescu et al., 2018, Carrillo et al., 2015, Ozkan et al., 2013)
                    DIP-ε - dpr6
                    enzyme linked immunosorbent assay
                    (Carrillo et al., 2015, Ozkan et al., 2013)
                    DIP-ε - dpr9
                    surface plasmon resonance, predetermined participant
                    (Cosmanescu et al., 2018)
                    Summary of Genetic Interactions
                    esyN Network Diagram
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    External Data
                    Linkouts
                    DroID - A comprehensive database of gene and protein interactions.
                    MIST (protein-protein) - An integrated Molecular Interaction Database
                    Pathways
                    Signaling Pathways (FlyBase)
                    Metabolic Pathways
                    External Data
                    Linkouts
                    Genomic Location and Detailed Mapping Data
                    Chromosome (arm)
                    2L
                    Recombination map

                    2-19

                    Cytogenetic map
                    26C4-26D1
                    Sequence location
                    2L:6,377,771..6,411,326 [-]
                    FlyBase Computed Cytological Location
                    Cytogenetic map
                    Evidence for location
                    26C4-26D1
                    Experimentally Determined Cytological Location
                    Cytogenetic map
                    Notes
                    References
                    Experimentally Determined Recombination Data
                    Location

                    2-19

                    (FlyBase, 2016)

                    2-20.6

                    (Comeron et al., 2012)
                    Left of (cM)
                    Right of (cM)
                    Notes
                    Stocks and Reagents
                    Stocks (8)
                    Genomic Clones (34)
                    cDNA Clones (10)
                     

                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                    cDNA clones, fully sequences
                    BDGP DGC clones
                    Other clones
                    Drosophila Genomics Resource Center cDNA clones

                    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                    cDNA Clones, End Sequenced (ESTs)
                    BDGP DGC clones
                      Other clones
                      RNAi and Array Information
                      Linkouts
                      DRSC - Results frm RNAi screens
                      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                      Antibody Information
                      Laboratory Generated Antibodies
                       
                      Commercially Available Antibodies
                       
                      Other Information
                      Relationship to Other Genes
                      Source for database identify of

                      Source for identity of: DIP-ε CG42368

                      (Ozkan et al., 2014.12.4)
                      Source for database merge of
                      Additional comments

                      Source for split of: CG13981

                      (FlyBase Genome Annotators, 2008)

                      Source for split of: CG33295

                      (FlyBase Genome Annotators, 2008)

                      Source for split of: CG9508

                      (FlyBase Genome Annotators, 2008)

                      Source for split of: CG9511

                      (FlyBase Genome Annotators, 2008)

                      Annotations CG13981, CG33295, CG9508, and CG9511 split into CG42368, CG42369 and CG42370 in release 5.10 of the genome annotation.

                      (FlyBase Genome Annotators, 2008)
                      Other Comments

                      New annotation (CG33295) in release 3.2 of the genome annotation.

                      (FlyBase Genome Annotators, 2004)
                      Origin and Etymology
                      Discoverer
                      Etymology
                      Identification
                      External Crossreferences and Linkouts ( 28 )
                      Sequence Crossreferences
                      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                      Other crossreferences
                      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                      Flygut - An atlas of the Drosophila adult midgut
                      FlyMine - An integrated database for Drosophila genomics
                      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                      InterPro - A database of protein families, domains and functional sites
                      KEGG Genes - Molecular building blocks of life in the genomic space.
                      modMine - A data warehouse for the modENCODE project
                      Linkouts
                      DroID - A comprehensive database of gene and protein interactions.
                      DRSC - Results frm RNAi screens
                      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                      MIST (protein-protein) - An integrated Molecular Interaction Database
                      Synonyms and Secondary IDs (9)
                      Datasets (0)
                      Study focus (0)
                      Experimental Role
                      Project
                      Project Type
                      Title
                      References (45)