Gene Dmel\CG42382

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General Information

Symbol

Dmel\CG42382

Species

D. melanogaster

Name

Annotation symbol

CG42382

Feature type

protein_coding_gene

FlyBase ID

FBgn0259728

Gene Model Status

Current

Stock availability

3 publicly available

Also Known As

CG8016

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

45B1-45B1

Sequence location

2R:5,054,071..5,055,013 [-]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol Dmel\CG42382 (FBgn0259728). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: zinc ion binding; nucleic acid binding. Based on sequence similarity, it is predicted to be involved in the biological process: DNA repair. 4 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: Zinc finger, CCCH-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1632496_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG42382. Gene sequence location is 2R:5054071..5055013.

User Contributed Data

Beta version, feedback welcome

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

FB2013_02

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

45B1-45B1

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\CG42382 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Gene model reviewed during 5.49

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

CG42382-RA

FBtr0299994

NM_078941

885

180

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

CG42382-PA

FBpp0289271

19.8

180

8.48

NP_523665

AAF58972

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Zinc finger, CCCH-type (IPR000571)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

A1Z7R9

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

(Fisher et al., 2012)

Comment:maternally deposited

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		69.2
Larval Midgut		18.6
Larval Hindgut		22.9
Larval Malpighian Tubules		31.1
Larval Fat Body		40.3
Larval Salivary Gland		25.3
Larval Trachea		42.125
Larval Carcass		36.3
Adult Head		28.2
Adult Eye		30.075
Adult Brain		43.1
Adult Thoracic-Abdominal Ganglion		38.8
Adult Crop		29
Adult Midgut		24
Adult Hindgut		29.3
Adult Malpighian Tubules		19.7
Adult Fat Body		27.3
Adult Salivary Gland		52.2
Adult Heart		16.05
Adult VirginFemale Spermatheca		12.5
Adult InseminatedFemale Spermatheca		20.3
Adult Ovary		49.5
Adult Testis		11.8
Adult Male Accessory Gland		36.3
Adult Carcass		24.7
Expression Level Scale		None Low

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		69.2
Larval Midgut		18.6
Larval Hindgut		22.9
Larval Malpighian Tubules		31.1
Larval Fat Body		40.3
Larval Salivary Gland		25.3
Larval Trachea		42.125
Larval Carcass		36.3
Adult Head		28.2
Adult Eye		30.075
Adult Brain		43.1
Adult Thoracic-Abdominal Ganglion		38.8
Adult Crop		29
Adult Midgut		24
Adult Hindgut		29.3
Adult Malpighian Tubules		19.7
Adult Fat Body		27.3
Adult Salivary Gland		52.2
Adult Heart		16.05
Adult VirginFemale Spermatheca		12.5
Adult InseminatedFemale Spermatheca		20.3
Adult Ovary		49.5
Adult Testis		11.8
Adult Male Accessory Gland		36.3
Adult Carcass		24.7
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		69.2
Larval Midgut		18.6
Larval Hindgut		22.9
Larval Malpighian Tubules		31.1
Larval Fat Body		40.3
Larval Salivary Gland		25.3
Larval Trachea		42.125
Larval Carcass		36.3
Adult Head		28.2
Adult Eye		30.075
Adult Brain		43.1
Adult Thoracic-Abdominal Ganglion		38.8
Adult Crop		29
Adult Midgut		24
Adult Hindgut		29.3
Adult Malpighian Tubules		19.7
Adult Fat Body		27.3
Adult Salivary Gland		52.2
Adult Heart		16.05
Adult VirginFemale Spermatheca		12.5
Adult InseminatedFemale Spermatheca		20.3
Adult Ovary		49.5
Adult Testis		11.8
Adult Male Accessory Gland		36.3
Adult Carcass		24.7
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		69.2
Larval Midgut		18.6
Larval Hindgut		22.9
Larval Malpighian Tubules		31.1
Larval Fat Body		40.3
Larval Salivary Gland		25.3
Larval Trachea		42.125
Larval Carcass		36.3
Adult Head		28.2
Adult Eye		30.075
Adult Brain		43.1
Adult Thoracic-Abdominal Ganglion		38.8
Adult Crop		29
Adult Midgut		24
Adult Hindgut		29.3
Adult Malpighian Tubules		19.7
Adult Fat Body		27.3
Adult Salivary Gland		52.2
Adult Heart		16.05
Adult VirginFemale Spermatheca		12.5
Adult InseminatedFemale Spermatheca		20.3
Adult Ovary		49.5
Adult Testis		11.8
Adult Male Accessory Gland		36.3
Adult Carcass		24.7
Expression Level Scale		Very high

log, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		69.2
Larval Midgut		18.6
Larval Hindgut		22.9
Larval Malpighian Tubules		31.1
Larval Fat Body		40.3
Larval Salivary Gland		25.3
Larval Trachea		42.125
Larval Carcass		36.3
Adult Head		28.2
Adult Eye		30.075
Adult Brain		43.1
Adult Thoracic-Abdominal Ganglion		38.8
Adult Crop		29
Adult Midgut		24
Adult Hindgut		29.3
Adult Malpighian Tubules		19.7
Adult Fat Body		27.3
Adult Salivary Gland		52.2
Adult Heart		16.05
Adult VirginFemale Spermatheca		12.5
Adult InseminatedFemale Spermatheca		20.3
Adult Ovary		49.5
Adult Testis		11.8
Adult Male Accessory Gland		36.3
Adult Carcass		24.7
Expression Level Scale		None Low Moderate

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		69.2
Larval Midgut		18.6
Larval Hindgut		22.9
Larval Malpighian Tubules		31.1
Larval Fat Body		40.3
Larval Salivary Gland		25.3
Larval Trachea		42.125
Larval Carcass		36.3
Adult Head		28.2
Adult Eye		30.075
Adult Brain		43.1
Adult Thoracic-Abdominal Ganglion		38.8
Adult Crop		29
Adult Midgut		24
Adult Hindgut		29.3
Adult Malpighian Tubules		19.7
Adult Fat Body		27.3
Adult Salivary Gland		52.2
Adult Heart		16.05
Adult VirginFemale Spermatheca		12.5
Adult InseminatedFemale Spermatheca		20.3
Adult Ovary		49.5
Adult Testis		11.8
Adult Male Accessory Gland		36.3
Adult Carcass		24.7
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		69.2
Larval Midgut		18.6
Larval Hindgut		22.9
Larval Malpighian Tubules		31.1
Larval Fat Body		40.3
Larval Salivary Gland		25.3
Larval Trachea		42.125
Larval Carcass		36.3
Adult Head		28.2
Adult Eye		30.075
Adult Brain		43.1
Adult Thoracic-Abdominal Ganglion		38.8
Adult Crop		29
Adult Midgut		24
Adult Hindgut		29.3
Adult Malpighian Tubules		19.7
Adult Fat Body		27.3
Adult Salivary Gland		52.2
Adult Heart		16.05
Adult VirginFemale Spermatheca		12.5
Adult InseminatedFemale Spermatheca		20.3
Adult Ovary		49.5
Adult Testis		11.8
Adult Male Accessory Gland		36.3
Adult Carcass		24.7
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		69.2
Larval Midgut		18.6
Larval Hindgut		22.9
Larval Malpighian Tubules		31.1
Larval Fat Body		40.3
Larval Salivary Gland		25.3
Larval Trachea		42.125
Larval Carcass		36.3
Adult Head		28.2
Adult Eye		30.075
Adult Brain		43.1
Adult Thoracic-Abdominal Ganglion		38.8
Adult Crop		29
Adult Midgut		24
Adult Hindgut		29.3
Adult Malpighian Tubules		19.7
Adult Fat Body		27.3
Adult Salivary Gland		52.2
Adult Heart		16.05
Adult VirginFemale Spermatheca		12.5
Adult InseminatedFemale Spermatheca		20.3
Adult Ovary		49.5
Adult Testis		11.8
Adult Male Accessory Gland		36.3
Adult Carcass		24.7
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	28.2
NA	Eye	30.075
NA	Brain	43.1
69.2	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	38.8
NA	Crop	no informative data
no informative data	Midgut	no informative data
no informative data	Hindgut	no informative data
no informative data	Malpighian Tubules	no informative data
no informative data	Fat Body	no informative data
no informative data	Salivary Gland	no informative data
NA	Heart	16.05
42.125	Trachea	NA
NA	VirginFemale Spermatheca	no informative data
NA	InseminatedFemale Spermatheca	no informative data
NA	Ovary	49.5
NA	Testis	no informative data
NA	Male Accessory Gland	no informative data
no informative data	Carcass	no informative data

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		7
central nervous system, larvae L3		10
central nervous system, pupae P8		5
head, virgin 1-day female		2
head, virgin 4-day female		3
head, virgin 20-day female		2
head, mated 1-day female		2
head, mated 4-day female		3
head, mated 20-day female		2
head, mated 1-day male		4
head, mated 4-day male		4
head, mated 20-day male		7
salivary gland, larvae L3 wandering		2
salivary gland, white prepupae		2
digestive system, larvae L3 wandering		3
digestive system, 1-day adult		2
digestive system, 4-day adult		2
digestive system, 20-day adult		2
fat body, larvae L3 wandering		1
fat body, white prepupae		2
fat body, pupae P8		6
carcass, larvae L3 wandering		6
carcass, 1-day adult		2
carcass, 4-day adult		2
carcass, 20-day adult		2
ovary, virgin 4-day female		9
ovary, mated 4-day female		7
testis, mated 4-day male		4
accessory gland, mated 4-day male		2
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		7
central nervous system, larvae L3		10
central nervous system, pupae P8		5
head, virgin 1-day female		2
head, virgin 4-day female		3
head, virgin 20-day female		2
head, mated 1-day female		2
head, mated 4-day female		3
head, mated 20-day female		2
head, mated 1-day male		4
head, mated 4-day male		4
head, mated 20-day male		7
salivary gland, larvae L3 wandering		2
salivary gland, white prepupae		2
digestive system, larvae L3 wandering		3
digestive system, 1-day adult		2
digestive system, 4-day adult		2
digestive system, 20-day adult		2
fat body, larvae L3 wandering		1
fat body, white prepupae		2
fat body, pupae P8		6
carcass, larvae L3 wandering		6
carcass, 1-day adult		2
carcass, 4-day adult		2
carcass, 20-day adult		2
ovary, virgin 4-day female		9
ovary, mated 4-day female		7
testis, mated 4-day male		4
accessory gland, mated 4-day male		2
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		7
central nervous system, larvae L3		10
central nervous system, pupae P8		5
head, virgin 1-day female		2
head, virgin 4-day female		3
head, virgin 20-day female		2
head, mated 1-day female		2
head, mated 4-day female		3
head, mated 20-day female		2
head, mated 1-day male		4
head, mated 4-day male		4
head, mated 20-day male		7
salivary gland, larvae L3 wandering		2
salivary gland, white prepupae		2
digestive system, larvae L3 wandering		3
digestive system, 1-day adult		2
digestive system, 4-day adult		2
digestive system, 20-day adult		2
fat body, larvae L3 wandering		1
fat body, white prepupae		2
fat body, pupae P8		6
carcass, larvae L3 wandering		6
carcass, 1-day adult		2
carcass, 4-day adult		2
carcass, 20-day adult		2
ovary, virgin 4-day female		9
ovary, mated 4-day female		7
testis, mated 4-day male		4
accessory gland, mated 4-day male		2
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		7
central nervous system, larvae L3		10
central nervous system, pupae P8		5
head, virgin 1-day female		2
head, virgin 4-day female		3
head, virgin 20-day female		2
head, mated 1-day female		2
head, mated 4-day female		3
head, mated 20-day female		2
head, mated 1-day male		4
head, mated 4-day male		4
head, mated 20-day male		7
salivary gland, larvae L3 wandering		2
salivary gland, white prepupae		2
digestive system, larvae L3 wandering		3
digestive system, 1-day adult		2
digestive system, 4-day adult		2
digestive system, 20-day adult		2
fat body, larvae L3 wandering		1
fat body, white prepupae		2
fat body, pupae P8		6
carcass, larvae L3 wandering		6
carcass, 1-day adult		2
carcass, 4-day adult		2
carcass, 20-day adult		2
ovary, virgin 4-day female		9
ovary, mated 4-day female		7
testis, mated 4-day male		4
accessory gland, mated 4-day male		2
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		7
central nervous system, larvae L3		10
central nervous system, pupae P8		5
head, virgin 1-day female		2
head, virgin 4-day female		3
head, virgin 20-day female		2
head, mated 1-day female		2
head, mated 4-day female		3
head, mated 20-day female		2
head, mated 1-day male		4
head, mated 4-day male		4
head, mated 20-day male		7
salivary gland, larvae L3 wandering		2
salivary gland, white prepupae		2
digestive system, larvae L3 wandering		3
digestive system, 1-day adult		2
digestive system, 4-day adult		2
digestive system, 20-day adult		2
fat body, larvae L3 wandering		1
fat body, white prepupae		2
fat body, pupae P8		6
carcass, larvae L3 wandering		6
carcass, 1-day adult		2
carcass, 4-day adult		2
carcass, 20-day adult		2
ovary, virgin 4-day female		9
ovary, mated 4-day female		7
testis, mated 4-day male		4
accessory gland, mated 4-day male		2
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		7
central nervous system, larvae L3		10
central nervous system, pupae P8		5
head, virgin 1-day female		2
head, virgin 4-day female		3
head, virgin 20-day female		2
head, mated 1-day female		2
head, mated 4-day female		3
head, mated 20-day female		2
head, mated 1-day male		4
head, mated 4-day male		4
head, mated 20-day male		7
salivary gland, larvae L3 wandering		2
salivary gland, white prepupae		2
digestive system, larvae L3 wandering		3
digestive system, 1-day adult		2
digestive system, 4-day adult		2
digestive system, 20-day adult		2
fat body, larvae L3 wandering		1
fat body, white prepupae		2
fat body, pupae P8		6
carcass, larvae L3 wandering		6
carcass, 1-day adult		2
carcass, 4-day adult		2
carcass, 20-day adult		2
ovary, virgin 4-day female		9
ovary, mated 4-day female		7
testis, mated 4-day male		4
accessory gland, mated 4-day male		2
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		7
central nervous system, larvae L3		10
central nervous system, pupae P8		5
head, virgin 1-day female		2
head, virgin 4-day female		3
head, virgin 20-day female		2
head, mated 1-day female		2
head, mated 4-day female		3
head, mated 20-day female		2
head, mated 1-day male		4
head, mated 4-day male		4
head, mated 20-day male		7
salivary gland, larvae L3 wandering		2
salivary gland, white prepupae		2
digestive system, larvae L3 wandering		3
digestive system, 1-day adult		2
digestive system, 4-day adult		2
digestive system, 20-day adult		2
fat body, larvae L3 wandering		1
fat body, white prepupae		2
fat body, pupae P8		6
carcass, larvae L3 wandering		6
carcass, 1-day adult		2
carcass, 4-day adult		2
carcass, 20-day adult		2
ovary, virgin 4-day female		9
ovary, mated 4-day female		7
testis, mated 4-day male		4
accessory gland, mated 4-day male		2
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		7
central nervous system, larvae L3		10
central nervous system, pupae P8		5
head, virgin 1-day female		2
head, virgin 4-day female		3
head, virgin 20-day female		2
head, mated 1-day female		2
head, mated 4-day female		3
head, mated 20-day female		2
head, mated 1-day male		4
head, mated 4-day male		4
head, mated 20-day male		7
salivary gland, larvae L3 wandering		2
salivary gland, white prepupae		2
digestive system, larvae L3 wandering		3
digestive system, 1-day adult		2
digestive system, 4-day adult		2
digestive system, 20-day adult		2
fat body, larvae L3 wandering		1
fat body, white prepupae		2
fat body, pupae P8		6
carcass, larvae L3 wandering		6
carcass, 1-day adult		2
carcass, 4-day adult		2
carcass, 20-day adult		2
ovary, virgin 4-day female		9
ovary, mated 4-day female		7
testis, mated 4-day male		4
accessory gland, mated 4-day male		2
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in adult female stages.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		6
embryo 02-04hr		3
embryo 04-06hr		5
embryo 06-08hr		5
embryo 08-10hr		9
embryo 10-12hr		8
embryo 12-14hr		4
embryo 14-16hr		2
embryo 16-18hr		3
embryo 18-20hr		2
embryo 20-22hr		1
embryo 22-24hr		2
larva L1		2
larva L2		3
larva L3 12hr old		2
larva L3 puffstage 1-2		1
larva L3 puffstage 3-6		3
larva L3 puffstage 7-9		4
white prepupae new		4
white prepupae 12hr		5
white prepupae 24hr		6
pupae 2d postWPP		5
pupae 3d postWPP		2
pupae 4d postWPP		1
adult male 01day		2
adult male 05day		2
adult male 30day		2
adult female 01day		3
adult female 05day		5
adult female 30day		4
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		6
embryo 02-04hr		3
embryo 04-06hr		5
embryo 06-08hr		5
embryo 08-10hr		9
embryo 10-12hr		8
embryo 12-14hr		4
embryo 14-16hr		2
embryo 16-18hr		3
embryo 18-20hr		2
embryo 20-22hr		1
embryo 22-24hr		2
larva L1		2
larva L2		3
larva L3 12hr old		2
larva L3 puffstage 1-2		1
larva L3 puffstage 3-6		3
larva L3 puffstage 7-9		4
white prepupae new		4
white prepupae 12hr		5
white prepupae 24hr		6
pupae 2d postWPP		5
pupae 3d postWPP		2
pupae 4d postWPP		1
adult male 01day		2
adult male 05day		2
adult male 30day		2
adult female 01day		3
adult female 05day		5
adult female 30day		4
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		6
embryo 02-04hr		3
embryo 04-06hr		5
embryo 06-08hr		5
embryo 08-10hr		9
embryo 10-12hr		8
embryo 12-14hr		4
embryo 14-16hr		2
embryo 16-18hr		3
embryo 18-20hr		2
embryo 20-22hr		1
embryo 22-24hr		2
larva L1		2
larva L2		3
larva L3 12hr old		2
larva L3 puffstage 1-2		1
larva L3 puffstage 3-6		3
larva L3 puffstage 7-9		4
white prepupae new		4
white prepupae 12hr		5
white prepupae 24hr		6
pupae 2d postWPP		5
pupae 3d postWPP		2
pupae 4d postWPP		1
adult male 01day		2
adult male 05day		2
adult male 30day		2
adult female 01day		3
adult female 05day		5
adult female 30day		4
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		6
embryo 02-04hr		3
embryo 04-06hr		5
embryo 06-08hr		5
embryo 08-10hr		9
embryo 10-12hr		8
embryo 12-14hr		4
embryo 14-16hr		2
embryo 16-18hr		3
embryo 18-20hr		2
embryo 20-22hr		1
embryo 22-24hr		2
larva L1		2
larva L2		3
larva L3 12hr old		2
larva L3 puffstage 1-2		1
larva L3 puffstage 3-6		3
larva L3 puffstage 7-9		4
white prepupae new		4
white prepupae 12hr		5
white prepupae 24hr		6
pupae 2d postWPP		5
pupae 3d postWPP		2
pupae 4d postWPP		1
adult male 01day		2
adult male 05day		2
adult male 30day		2
adult female 01day		3
adult female 05day		5
adult female 30day		4
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		6
embryo 02-04hr		3
embryo 04-06hr		5
embryo 06-08hr		5
embryo 08-10hr		9
embryo 10-12hr		8
embryo 12-14hr		4
embryo 14-16hr		2
embryo 16-18hr		3
embryo 18-20hr		2
embryo 20-22hr		1
embryo 22-24hr		2
larva L1		2
larva L2		3
larva L3 12hr old		2
larva L3 puffstage 1-2		1
larva L3 puffstage 3-6		3
larva L3 puffstage 7-9		4
white prepupae new		4
white prepupae 12hr		5
white prepupae 24hr		6
pupae 2d postWPP		5
pupae 3d postWPP		2
pupae 4d postWPP		1
adult male 01day		2
adult male 05day		2
adult male 30day		2
adult female 01day		3
adult female 05day		5
adult female 30day		4
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		6
embryo 02-04hr		3
embryo 04-06hr		5
embryo 06-08hr		5
embryo 08-10hr		9
embryo 10-12hr		8
embryo 12-14hr		4
embryo 14-16hr		2
embryo 16-18hr		3
embryo 18-20hr		2
embryo 20-22hr		1
embryo 22-24hr		2
larva L1		2
larva L2		3
larva L3 12hr old		2
larva L3 puffstage 1-2		1
larva L3 puffstage 3-6		3
larva L3 puffstage 7-9		4
white prepupae new		4
white prepupae 12hr		5
white prepupae 24hr		6
pupae 2d postWPP		5
pupae 3d postWPP		2
pupae 4d postWPP		1
adult male 01day		2
adult male 05day		2
adult male 30day		2
adult female 01day		3
adult female 05day		5
adult female 30day		4
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		6
embryo 02-04hr		3
embryo 04-06hr		5
embryo 06-08hr		5
embryo 08-10hr		9
embryo 10-12hr		8
embryo 12-14hr		4
embryo 14-16hr		2
embryo 16-18hr		3
embryo 18-20hr		2
embryo 20-22hr		1
embryo 22-24hr		2
larva L1		2
larva L2		3
larva L3 12hr old		2
larva L3 puffstage 1-2		1
larva L3 puffstage 3-6		3
larva L3 puffstage 7-9		4
white prepupae new		4
white prepupae 12hr		5
white prepupae 24hr		6
pupae 2d postWPP		5
pupae 3d postWPP		2
pupae 4d postWPP		1
adult male 01day		2
adult male 05day		2
adult male 30day		2
adult female 01day		3
adult female 05day		5
adult female 30day		4
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		6
embryo 02-04hr		3
embryo 04-06hr		5
embryo 06-08hr		5
embryo 08-10hr		9
embryo 10-12hr		8
embryo 12-14hr		4
embryo 14-16hr		2
embryo 16-18hr		3
embryo 18-20hr		2
embryo 20-22hr		1
embryo 22-24hr		2
larva L1		2
larva L2		3
larva L3 12hr old		2
larva L3 puffstage 1-2		1
larva L3 puffstage 3-6		3
larva L3 puffstage 7-9		4
white prepupae new		4
white prepupae 12hr		5
white prepupae 24hr		6
pupae 2d postWPP		5
pupae 3d postWPP		2
pupae 4d postWPP		1
adult male 01day		2
adult male 05day		2
adult male 30day		2
adult female 01day		3
adult female 05day		5
adult female 30day		4
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		17
Schneider line 2 Sg4		14
embryonic 1182-4H		8
embryonic GM2		16
embryonic Kc167		15
embryonic S1		15
embryonic S3		17
leg disc CME L1		9
wing disc CME-W2		12
wing disc ML-DmD8		11
wing disc ML-DmD9		7
wing disc ML-DmD16-c3		4
wing disc ML-DmD21		16
wing disc ML-DmD32		12
haltere disc ML-DmD17-c3		15
eye-antennal disc ML-DmD11		10
antennal disc ML-DmD20-c5		22
mixed discs ML-DmD4-c1		12
CNS ML-DmBG1-c1		11
CNS ML-DmBG2-c2		30
tumorous blood cells mbn2		7
ovary fGS/OSS		2
ovary OSC		3
ovary OSS		3
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		17
Schneider line 2 Sg4		14
embryonic 1182-4H		8
embryonic GM2		16
embryonic Kc167		15
embryonic S1		15
embryonic S3		17
leg disc CME L1		9
wing disc CME-W2		12
wing disc ML-DmD8		11
wing disc ML-DmD9		7
wing disc ML-DmD16-c3		4
wing disc ML-DmD21		16
wing disc ML-DmD32		12
haltere disc ML-DmD17-c3		15
eye-antennal disc ML-DmD11		10
antennal disc ML-DmD20-c5		22
mixed discs ML-DmD4-c1		12
CNS ML-DmBG1-c1		11
CNS ML-DmBG2-c2		(30)
tumorous blood cells mbn2		7
ovary fGS/OSS		2
ovary OSC		3
ovary OSS		3
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		17
Schneider line 2 Sg4		14
embryonic 1182-4H		8
embryonic GM2		16
embryonic Kc167		15
embryonic S1		15
embryonic S3		17
leg disc CME L1		9
wing disc CME-W2		12
wing disc ML-DmD8		11
wing disc ML-DmD9		7
wing disc ML-DmD16-c3		4
wing disc ML-DmD21		16
wing disc ML-DmD32		12
haltere disc ML-DmD17-c3		15
eye-antennal disc ML-DmD11		10
antennal disc ML-DmD20-c5		22
mixed discs ML-DmD4-c1		12
CNS ML-DmBG1-c1		11
CNS ML-DmBG2-c2		30
tumorous blood cells mbn2		7
ovary fGS/OSS		2
ovary OSC		3
ovary OSS		3
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		17
Schneider line 2 Sg4		14
embryonic 1182-4H		8
embryonic GM2		16
embryonic Kc167		15
embryonic S1		15
embryonic S3		17
leg disc CME L1		9
wing disc CME-W2		12
wing disc ML-DmD8		11
wing disc ML-DmD9		7
wing disc ML-DmD16-c3		4
wing disc ML-DmD21		16
wing disc ML-DmD32		12
haltere disc ML-DmD17-c3		15
eye-antennal disc ML-DmD11		10
antennal disc ML-DmD20-c5		22
mixed discs ML-DmD4-c1		12
CNS ML-DmBG1-c1		11
CNS ML-DmBG2-c2		30
tumorous blood cells mbn2		7
ovary fGS/OSS		2
ovary OSC		3
ovary OSS		3
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		17
Schneider line 2 Sg4		14
embryonic 1182-4H		8
embryonic GM2		16
embryonic Kc167		15
embryonic S1		15
embryonic S3		17
leg disc CME L1		9
wing disc CME-W2		12
wing disc ML-DmD8		11
wing disc ML-DmD9		7
wing disc ML-DmD16-c3		4
wing disc ML-DmD21		16
wing disc ML-DmD32		12
haltere disc ML-DmD17-c3		15
eye-antennal disc ML-DmD11		10
antennal disc ML-DmD20-c5		22
mixed discs ML-DmD4-c1		12
CNS ML-DmBG1-c1		11
CNS ML-DmBG2-c2		30
tumorous blood cells mbn2		7
ovary fGS/OSS		2
ovary OSC		3
ovary OSS		3
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		17
Schneider line 2 Sg4		14
embryonic 1182-4H		8
embryonic GM2		16
embryonic Kc167		15
embryonic S1		15
embryonic S3		17
leg disc CME L1		9
wing disc CME-W2		12
wing disc ML-DmD8		11
wing disc ML-DmD9		7
wing disc ML-DmD16-c3		4
wing disc ML-DmD21		16
wing disc ML-DmD32		12
haltere disc ML-DmD17-c3		15
eye-antennal disc ML-DmD11		10
antennal disc ML-DmD20-c5		22
mixed discs ML-DmD4-c1		12
CNS ML-DmBG1-c1		11
CNS ML-DmBG2-c2		30
tumorous blood cells mbn2		7
ovary fGS/OSS		2
ovary OSC		3
ovary OSS		3
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		17
Schneider line 2 Sg4		14
embryonic 1182-4H		8
embryonic GM2		16
embryonic Kc167		15
embryonic S1		15
embryonic S3		17
leg disc CME L1		9
wing disc CME-W2		12
wing disc ML-DmD8		11
wing disc ML-DmD9		7
wing disc ML-DmD16-c3		4
wing disc ML-DmD21		16
wing disc ML-DmD32		12
haltere disc ML-DmD17-c3		15
eye-antennal disc ML-DmD11		10
antennal disc ML-DmD20-c5		22
mixed discs ML-DmD4-c1		12
CNS ML-DmBG1-c1		11
CNS ML-DmBG2-c2		30
tumorous blood cells mbn2		7
ovary fGS/OSS		2
ovary OSC		3
ovary OSS		3
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		17
Schneider line 2 Sg4		14
embryonic 1182-4H		8
embryonic GM2		16
embryonic Kc167		15
embryonic S1		15
embryonic S3		17
leg disc CME L1		9
wing disc CME-W2		12
wing disc ML-DmD8		11
wing disc ML-DmD9		7
wing disc ML-DmD16-c3		4
wing disc ML-DmD21		16
wing disc ML-DmD32		12
haltere disc ML-DmD17-c3		15
eye-antennal disc ML-DmD11		10
antennal disc ML-DmD20-c5		22
mixed discs ML-DmD4-c1		12
CNS ML-DmBG1-c1		11
CNS ML-DmBG2-c2		30
tumorous blood cells mbn2		7
ovary fGS/OSS		2
ovary OSC		3
ovary OSS		3
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		3
cold shock, 4-day adult		3
heat shock, 4-day adult		4
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		5
Cadmium 100 mM 48 hrs, 4-day adult		5
Copper 0.5 mM 12 hrs, larvae L3		0
Copper 15 mM 48 hrs, 4-day adult		6
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		4
Ethanol 2.5% 3 hrs, larvae L3		5
Ethanol 5% 3 hrs, larvae L3		5
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		6
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		11
Caffeine 25 mg/ml 48 hrs, 4-day adult		3
Paraquat 5 mM 48 hrs, 4-day adult		5
Paraquat 10 mM 48 hrs, 4-day adult		5
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		3
cold shock, 4-day adult		3
heat shock, 4-day adult		4
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		5
Cadmium 100 mM 48 hrs, 4-day adult		5
Copper 0.5 mM 12 hrs, larvae L3		0
Copper 15 mM 48 hrs, 4-day adult		6
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		4
Ethanol 2.5% 3 hrs, larvae L3		5
Ethanol 5% 3 hrs, larvae L3		5
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		6
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		11
Caffeine 25 mg/ml 48 hrs, 4-day adult		3
Paraquat 5 mM 48 hrs, 4-day adult		5
Paraquat 10 mM 48 hrs, 4-day adult		5
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		3
cold shock, 4-day adult		3
heat shock, 4-day adult		4
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		5
Cadmium 100 mM 48 hrs, 4-day adult		5
Copper 0.5 mM 12 hrs, larvae L3		0
Copper 15 mM 48 hrs, 4-day adult		6
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		4
Ethanol 2.5% 3 hrs, larvae L3		5
Ethanol 5% 3 hrs, larvae L3		5
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		6
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		11
Caffeine 25 mg/ml 48 hrs, 4-day adult		3
Paraquat 5 mM 48 hrs, 4-day adult		5
Paraquat 10 mM 48 hrs, 4-day adult		5
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		3
cold shock, 4-day adult		3
heat shock, 4-day adult		4
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		5
Cadmium 100 mM 48 hrs, 4-day adult		5
Copper 0.5 mM 12 hrs, larvae L3		0
Copper 15 mM 48 hrs, 4-day adult		6
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		4
Ethanol 2.5% 3 hrs, larvae L3		5
Ethanol 5% 3 hrs, larvae L3		5
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		6
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		11
Caffeine 25 mg/ml 48 hrs, 4-day adult		3
Paraquat 5 mM 48 hrs, 4-day adult		5
Paraquat 10 mM 48 hrs, 4-day adult		5
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		3
cold shock, 4-day adult		3
heat shock, 4-day adult		4
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		5
Cadmium 100 mM 48 hrs, 4-day adult		5
Copper 0.5 mM 12 hrs, larvae L3		0
Copper 15 mM 48 hrs, 4-day adult		6
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		4
Ethanol 2.5% 3 hrs, larvae L3		5
Ethanol 5% 3 hrs, larvae L3		5
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		6
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		11
Caffeine 25 mg/ml 48 hrs, 4-day adult		3
Paraquat 5 mM 48 hrs, 4-day adult		5
Paraquat 10 mM 48 hrs, 4-day adult		5
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		3
cold shock, 4-day adult		3
heat shock, 4-day adult		4
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		5
Cadmium 100 mM 48 hrs, 4-day adult		5
Copper 0.5 mM 12 hrs, larvae L3		0
Copper 15 mM 48 hrs, 4-day adult		6
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		4
Ethanol 2.5% 3 hrs, larvae L3		5
Ethanol 5% 3 hrs, larvae L3		5
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		6
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		11
Caffeine 25 mg/ml 48 hrs, 4-day adult		3
Paraquat 5 mM 48 hrs, 4-day adult		5
Paraquat 10 mM 48 hrs, 4-day adult		5
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		3
cold shock, 4-day adult		3
heat shock, 4-day adult		4
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		5
Cadmium 100 mM 48 hrs, 4-day adult		5
Copper 0.5 mM 12 hrs, larvae L3		0
Copper 15 mM 48 hrs, 4-day adult		6
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		4
Ethanol 2.5% 3 hrs, larvae L3		5
Ethanol 5% 3 hrs, larvae L3		5
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		6
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		11
Caffeine 25 mg/ml 48 hrs, 4-day adult		3
Paraquat 5 mM 48 hrs, 4-day adult		5
Paraquat 10 mM 48 hrs, 4-day adult		5
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		3
cold shock, 4-day adult		3
heat shock, 4-day adult		4
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		5
Cadmium 100 mM 48 hrs, 4-day adult		5
Copper 0.5 mM 12 hrs, larvae L3		0
Copper 15 mM 48 hrs, 4-day adult		6
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		4
Ethanol 2.5% 3 hrs, larvae L3		5
Ethanol 5% 3 hrs, larvae L3		5
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		6
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		11
Caffeine 25 mg/ml 48 hrs, 4-day adult		3
Paraquat 5 mM 48 hrs, 4-day adult		5
Paraquat 10 mM 48 hrs, 4-day adult		5
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010, Graveley et al., 2011)

External Data & Images

Linkouts

BDGP expression data

•

RH63179

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0259728

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable, with Scer\GAL4^pnr-MD237

Other Phenotypes

Allele

visible, with Scer\GAL4^pnr-MD237

CG42382^GD4197

Phenotype manifest in

Allele

mesothoracic tergum, with Scer\GAL4^pnr-MD237

CG42382^GD4197

Classical Alleles ( 1 )

For All Classical Alleles Show

Allele of CG42382	Class	Mutagen	Stocks	Known lesion
CG42382^G18927		P-element activity	1	--

Alleles Carried on Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Allele of CG42382	Mutagen	Stocks	Known lesion
CG42382^GD17262	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
CG42382^GD4197	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
CG42382^KK111052	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes

Aneuploid Aberrations

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD4197}

P{GD17262}

P{KK111052}

Insertions

Type of insertions

Name

Expression data

insertion of mobile activating element

P{EP}CG42382^G18927

Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )

Terms Based on Experimental Evidence ( 0 terms )

Terms Based on Predictions or Assertions ( 3 terms )

Molecular Function

CV term

Evidence

References

nucleic acid binding

inferred from electronic annotation with InterPro:IPR000571

(FlyBase Curators et al., 2004-)

zinc ion binding

inferred from electronic annotation with InterPro:IPR000571

(FlyBase Curators et al., 2004-)

Biological Process

CV term

Evidence

References

DNA repair

inferred from sequence or structural similarity

(Burtis, 1999.11)

Cellular Component ( 0 terms)

Sequence Ontology: Class of Gene

nuclear_gene

(FlyBase Genome Annotators, 2008)

protein_coding_gene

(FlyBase Genome Annotators, 2008)

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

CG42382 allele

Gene

References

External Data

Linkouts

BioGRID - A database of protein and genetic interactions

•

61776

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0259728

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

35938

Orthologs

OrthoDB Orthologs (33) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG6H9Z67

Dipteran inclusive ortholog search

EOG6R2449

Insect inclusive ortholog search

EOG6NCK9C

Arthropod inclusive ortholog search

EOG6K6DMV

Metazoa inclusive ortholog search

EOG6GN6SF

Orthologs in Drosophila Species (EOG6H9Z67)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA20768

Drosophila persimilis

Dper\GL11137

Drosophila persimilis

Dper\GL18396

Drosophila persimilis

Dper\GL17461

Drosophila willistoni

Dwil\GK22866

Drosophila virilis

Dvir\GJ18563

Drosophila mojavensis

Dmoj\GI19818

Drosophila grimshawi

Dgri\GH19868

Orthologs in non-Drosophila Dipterans (EOG6R2449)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL015059

Anopheles gambiae

Malaria mosquito

Agam\AGAP006163

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ019715

Orthologs in non-Dipteran Insects (EOG6NCK9C)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Apis mellifera

Western honey bee

Amel\GB55789

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG006736

Acromyrmex echinatior

Panamanian leafcutter ant

Aech\AECH13558

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO13751

Harpegnathos saltator

Jerdons jumping ant

Hsal\HSAL21731

Linepithema humile

Argentine ant

Lhum\LH10404

Pogonomyrmex barbatus

Red harvester ant

Pbar\PB26072

Solenopsis invicta

Red fire ant

Sinv\SINV23133

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI009868

Bombyx mori

Silkmoth

Bmor\Bmo.12733

Pediculus humanus

Human body louse

Phum\PHUM369760

Tribolium castaneum

Red flour beetle

Tcas\TC012417

Orthologs in non-Insect Arthropods (EOG6K6DMV)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Ixodes scapularis

Deer tick

Isca\ISCW020733

Orthologs in non-Arthropod Metazoa (EOG6GN6SF)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Caenorhabditis elegans

Nematode

Cele\ccch-3

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_028429gn

Danio rerio

Zebrafish

Drer\si:ch211-113e8.11

Human Orthologs (0)

Gene

OMIM

HGNC

AAA Orthologs (0) based on analysis using Dmel annotation version 4.3

No orthologs identified

Stocks & Reagents

Stocks Listed in FlyBase ( 3 )

Bloomington

27450

y¹ w^*; P{EP}CG42382^G18927

VDRC

v10463

w¹¹¹⁸; P{GD4197}v10463

v46965

w¹¹¹⁸ P{GD17262}v46965

Genomic Clones ( 1 )

BACR10M14

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 9 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

RH63179

Other clones

FI09344

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

DRSC - Results from RNAi screens.

•

FBgn0259728

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

35938

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

The "rad201[1]" chromosome contains a number of lesions in two different genes. These are: F50L in the CG42382 annotation, and K61E, V93A and Y108H in the CG2412 annotation (corresponding to the Rad51C gene). In addition, an opus element is inserted in the Rad51C promoter region approximately 400bp upstream of the start codon. This mutant allele was isolated from a natural population, and thus it is not known which of the lesions are neutral and which cause the mutant phenotype.

(Khromykh et al., 2008)

FlyBase curator comment: information corresponding to the "rad201" complementation group has been separated out from information corresponding to the "CG8016" annotation in FlyBase, since evidence suggests that the "rad201" complementation group instead may correspond to the neighbouring annotation, CG2412. In addition, the CG8016 annotation has been renamed CG42382 in release 5.10 of the genome annotation to avoid confusion. The "rad201" complementation group has not yet been associated with the CG2412 annotation in FlyBase, as a lesion in CG2412 was only found in one out of two rad201 alleles tested in this paper.

(Chaouki and Salz, 2006)

The "rad201" complementation group has been associated with the "CG8016" annotation on FlyBase. However, evidence suggests that "rad201" instead corresponds to the neighbouring annotation, CG2412; the "rad201¹" allele has a lesion within the CG2412 open reading frame (although no lesion has been found in the "rad201^ZII-0670" allele), and the protein encoded by CG2412 interacts with Spf45 protein.

(Chaouki and Salz, 2006)

Other Comments

Annotation CG8016 renamed CG42382 in release 5.10 of the genome annotation.

(FlyBase Genome Annotators, 2008)

FlyBase curator comment: the gene referred to as "rad201" in the figure on page 299 corresponds to the CG42382 annotation. This annotation was previously linked to the rad201 mutant complementation group in FlyBase, which is probably why the annotation is labelled "rad201" in the Figure, but the annotation has since been separated out into its own gene report because evidence from FBrf0192968 suggests that the rad201 complementation group may correspond instead to the neighbouring Rad51C gene.

(Khromykh et al., 2008)

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_078941

RefSeq (Proteins)

•

NP_523665

DDBJ / EMBL / GenBank

•

Entrez Gene - A searchable database of RefSeq genes.

•

35938

UniProtKB/TrEMBL

•

A1Z7R9

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Zinc finger, CCCH-type (IPR000571)

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

•

RH63179

Linkouts

BioGRID - A database of protein and genetic interactions

•

61776

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0259728

DRSC - Results from RNAi screens.

•

FBgn0259728

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0259728

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0259728

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

35938

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

35938

modMine - Data generated by the modENCODE project.

•

FBgn0259728

Synonyms & Secondary IDs ( 2 )

Reported As

Symbol Synonym

CG8016

(Burtis, 1999.11, Giot et al., 2003, Chaouki and Salz, 2006, Keleman et al., 2009.8.5)

CG42382

(FlyBase Genome Annotators, 2008, )

Name Synonym

Secondary FlyBase IDs

FBgn0003194

References ( 17 )

Research paper

Khromykh et al., 2008, Russ. J. Genet. 44(3): 295--300: Epigenetic effect of the rad201(G1) mutation in a system with mobilization of nonautonomous P elements in Drosophila. [FBrf0205174]
Khromykh et al., 2008, Genetika, Moscow 44(3): 346--352: [Epigenetic effect of the rad201(G1) mutation in a system with mobilization of nonautonomous P elements in Drosophila] [FBrf0205862]
Chaouki and Salz, 2006, PLoS Genet. 2(12): e178: Drosophila SPF45: A Bifunctional Protein with Roles in Both Splicing and DNA Repair. [FBrf0192968]

Supplementary material

Graveley et al., 2011, Nature 471(7339):: Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980]
The modENCODE Consortium, 2010, Science 330(6012):: DataS14: Gene co-expression clusters. [FBrf0213979]
Mummery-Widmer et al., 2009, Nature 458(7241):: Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Giot et al., 2003, Science 302(5651):: Tables S1 to S7. [FBrf0166452]

Personal communication to FlyBase

Bellen, 2009.5.5, BDGP_2009_0507.GenExel.xml: BDGP_2009_0507.GenExel.xml [FBrf0207859]
Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510]
Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms.: Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file): Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]

FlyBase analysis

FlyBase Genome Annotators, 2008, Changes affecting gene model number or type in release 5.10 of the annotated D.melanogaster genome.: Changes affecting gene model number or type in release 5.10 of the annotated D.melanogaster genome. [FBrf0204955]
FlyBase, 1996-, FlyBase inference based on genome sequence analysis.: FlyBase inference based on genome sequence analysis. [FBrf0104946]
FlyBase, 1992-, FlyBase curation.: FlyBase curation. [FBrf0105495]

Curated genome annotation

Burtis, 1999.11, [Annotations performed at the Celera Jamboreee.]: [Annotations performed at the Celera Jamboreee.] [FBrf0126655]

Website

Fisher et al., 2012, BDGP insitu homepage: BDGP insitu homepage [FBrf0219073]