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Gene Dmel\ab

General Information
Symbol	Dmel\ab	Species	D. melanogaster
Name	abrupt	Annotation symbol	CG4807
Feature type	protein_coding_gene	FlyBase ID	FBgn0259750
Gene Model Status	Current	Stock availability	32 publicly available
Also Known As	clu
Genomic Location
Chromosome (arm)	2L	Recombination map	2-44.0
Cytogenetic map	32E1-32E2	Sequence location	2L:11,210,681..11,261,080 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene abrupt is referred to in FlyBase by the symbol Dmel\ab (CG4807, FBgn0259750). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: sequence-specific DNA binding transcription factor activity. There is experimental evidence that it is involved in the biological process: border follicle cell migration; dendrite morphogenesis; neuron development; muscle organ development. 47 alleles are reported. The phenotypes of these alleles are annotated with: hypodermal muscle of larval abdomen; organ system subdivision; organ system; adult segment; peripheral nervous system; larval abdominal segment; A1-7 dorsal oblique muscle 3; thoracic segment; hypodermal muscle of larval abdominal 2; abdominal 6 oblique muscle. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: BTB/POZ; BTB/POZ fold; BTB/POZ-like; Zinc finger, C2H2; Zinc finger, C2H2-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1629702_a_at completely aligns to an exonic region of only a subset of 3 of the 4 FlyBase-annotated transcript isoforms of ab. Gene sequence location is 2L:11210681..11261080.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	ab: abrupt ab: abrupt Edith M. Wallace, unpublished. Vein L5 usually stops after posterior crossvein. Scutellar bristles usually fewer. Wing effect probably acts during contraction period (Waddington). Overlaps wild type. Expression more severe in females than in males and when pupal stage takes place at 20 than at 25. TSP during the first 10% of pupal stage. (Thompson, Bruni, Carbonaro, and Russo, 1988, DIS 67: 86). RK2. ab2 Vein L5 does not reach margin. Scutellar bristles always fewer than wild type. Hairs parted down midline of thorax and abdomen. Supra-alar bristles sometimes absent. Coxae tend to be thickened. Males sterile and have rotated genitalia. ab/ab2 resembles ab/ab but has a stronger bristle effect. RK2.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	References Knowles-Barley, 2011.8.24, BrainTrap expression curation.
FB2012_01	References Cunha et al., 2010, PLoS Genet. 6: e1001014 Sequence features BKN30195 HFA03478
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 32E1-32E2   (determined by in situ hybridisation); Limits computationally determined from genome sequence between P{PZ}l(2)0400804008&P{PZ}cmet04431 and P{PZ}salm03602
Experimentally Determined Cytological Location
Cytogenetic map Notes References 32E1-32E2   (determined by in situ hybridisation); Limits computationally determined from genome sequence between P{PZ}l(2)0400804008&P{PZ}cmet04431 and P{PZ}salm03602   (Grieder et al., 2007) 32E1-32E2     (Crews, 1995.12.20) 32E1-32E2     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	2-44.0 (Edmondson, 1952)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\ab for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) ab-RA FBtr0080204  NM_057214   5139   904 ab-RB FBtr0080203  NM_057215   4837   894 ab-RC FBtr0300472  NM_001169480   1411   369 ab-RD FBtr0300473  NM_001169481   4885   894
Additional Transcript Data & Comments
Reported size (kB)	5.1 (northern blot) (Hu et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein ab-PA   FBpp0079793   95.1   904   6.28     NP_476562   AAF53087 ab-PB   FBpp0079792   94.0   894   6.17     NP_476563   AAN10774 ab-PC   FBpp0289699   38.7   369   5.72     NP_001162951   ACZ94238 ab-PD   FBpp0289700   94.0   894   6.17     NP_001162952   ACZ94239
Additional Polypeptide Data & Comments
Reported size (kDa)	904, 894 (aa) (Hu et al., 1995)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • BTB/POZ-like (IPR000210) Zinc finger, C2H2 (IPR007087) BTB/POZ (IPR013069) BTB/POZ fold (IPR011333) Zinc finger, C2H2-like (IPR015880)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140659   AA140963   AA141840   AA141842   AA142155   AA264347   AE014134 AAF53087   AE014134 AAN10774   AC006073   AC092241   AE014134 ACZ94238   AE014134 ACZ94239   AI257168   AQ025716   BF497208   BF499921   BI228386   BI581919   BI582174   BI611827   BI626050   BT001583 AAN71338   BT003807   BT023841   CK131584   CK661492   CL528185   CO185530   CO188878   CO190280   CO190900   CO196451   CO263573   CO263654   CO265004   CO271579   CO272531   CO274435   CO274635   CO277376   CO278682   CO281605   CO282965   CO283976   CO284787   CO288194   CO288886   CO292721   CO301526   CO301832   CO302321   CO311378   CO313232   CO314957   CO316444   CO318275   CO319901   CO320189   CO321029   CO326200   CO338699   CZ468985   CZ468986   CZ469995   CZ471000   CZ479690   CZ479691   CZ479987   CZ484753   CZ486675   CZ488198   CZ488989   EC062567   EC063933   EC065195   EC066488   EC067068   EC071615   EC071847   EC073818   EC076895   EC080841   EC081437   EC082187   EC083528   EC087285   EC089963   EC194648   EC196599   EC199639   EC202353   EC205718   EC211424   EC212758   EC213697   EC218962   EC219650   EC220966   EC221335   EC221552   EC227157   EC227478   EC227555   EC229373   EC239162   EC240204   EC240220   EC241434   EC242091   EC242437   EC246138   EC247047   EC256810   EC263557   EL874510   EL874511   EL874657   ES693200   ES693201   ES693203   ES693220   ES693246   EV596270   GH942869   GH947190   GH951881   GH955052   GH956175   GH958998   GH960250   GH965797   GH969057   GH970780   GH971841   GH977116   U43733 AAA86639
UniProtKB/Swiss-Prot	Q24174
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage   embryonic stomatogastric nervous system   (Hu et al., 1995) VUM precursor   (Hu et al., 1995) embryonic stage 9 -- 17   ventral midline   (Hu et al., 1995) embryonic stage 11 -- 17   epidermis   (Hu et al., 1995) embryonic stage 14 -- 17   embryonic/larval muscle system   (Hu et al., 1995) larval stage   eye-antennal disc   (Hu et al., 1995) imaginal disc   (Hu et al., 1995) wing disc   (Hu et al., 1995)
Additional Descriptive Data
	ab is expressed in all the cells of the ventral midline starting in stage 9. The only other site of nervous system expression is the stomatogastric nervous system and its precursors. Epidermal expression begins in stage 11 in a pattern of stripes and is uniform by stage 12. ab is expressed in all 30 embryonic abdominal muscles with the highest concentrations in the ventral longitudinal, ventral oblique, and segmental border muscles. ab is also expressed in all imaginal discs. (Hu et al., 1995)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage   embryonic stomatogastric nervous system   (Hu et al., 1995) VUM precursor   (Hu et al., 1995) embryonic stage 14 -- 17   embryonic/larval muscle system   (Hu et al., 1995) larval stage   wing disc   (Hu et al., 1995) immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   embryonic stomatogastric nervous system   (Hu et al., 1995) embryonic stage 9 -- 17   ventral midline   (Hu et al., 1995) embryonic stage 11 -- 17   epidermis   (Hu et al., 1995) larval stage   imaginal disc   (Hu et al., 1995) eye-antennal disc   (Hu et al., 1995)
Additional Descriptive Data
	ab is expressed in all the cells of the ventral midline starting in stage 9. The only other site of nervous system expression is the stomatogastric nervous system and its precursors. Epidermal expression begins in stage 11 in a pattern of stripes and is uniform by stage 12. ab is expressed in all 30 embryonic abdominal muscles with the highest concentrations in the ventral longitudinal, ventral oblique, and segmental border muscles. ab is also expressed in all imaginal discs. (Hu et al., 1995)
Marker for
Subcellular Localization
CV Term	nucleus (Hu et al., 1995)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0259750    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0259750 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0259750 expression level Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    408 embryo 04-06hr    1337 embryo 06-08hr    5681 embryo 08-10hr    6988 embryo 10-12hr    6490 embryo 12-14hr    7823 embryo 14-16hr    4183 embryo 16-18hr    1482 embryo 18-20hr    1343 embryo 20-22hr    1454 embryo 22-24hr    1334 larva L1    1139 larva L2    1190 larva L3 12hr old    769 larva L3 puffstage 1-2    436 larva L3 puffstage 3-6    684 larva L3 puffstage 7-9    940 white prepupae new    2205 white prepupae 12hr    3185 white prepupae 24hr    2479 pupae 2d postWPP    853 pupae 3d postWPP    425 pupae 4d postWPP    407 adult male 01day    509 adult male 05day    776 adult male 30day    660 adult female 01day    92 adult female 05day    43 adult female 30day    32 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr  (408) embryo 04-06hr  (1337) embryo 06-08hr  (5681) embryo 08-10hr  (6988) embryo 10-12hr  (6490) embryo 12-14hr  (7823) embryo 14-16hr  (4183) embryo 16-18hr  (1482) embryo 18-20hr  (1343) embryo 20-22hr  (1454) embryo 22-24hr  (1334) larva L1  (1139) larva L2  (1190) larva L3 12hr old  (769) larva L3 puffstage 1-2  (436) larva L3 puffstage 3-6  (684) larva L3 puffstage 7-9  (940) white prepupae new  (2205) white prepupae 12hr  (3185) white prepupae 24hr  (2479) pupae 2d postWPP  (853) pupae 3d postWPP  (425) pupae 4d postWPP  (407) adult male 01day  (509) adult male 05day  (776) adult male 30day  (660) adult female 01day    92 adult female 05day    43 adult female 30day    32 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    408 embryo 04-06hr    1337 embryo 06-08hr  (5681) embryo 08-10hr  (6988) embryo 10-12hr  (6490) embryo 12-14hr  (7823) embryo 14-16hr  (4183) embryo 16-18hr  1482 embryo 18-20hr    1343 embryo 20-22hr  1454 embryo 22-24hr    1334 larva L1    1139 larva L2    1190 larva L3 12hr old    769 larva L3 puffstage 1-2    436 larva L3 puffstage 3-6    684 larva L3 puffstage 7-9    940 white prepupae new  (2205) white prepupae 12hr  (3185) white prepupae 24hr  (2479) pupae 2d postWPP    853 pupae 3d postWPP    425 pupae 4d postWPP    407 adult male 01day    509 adult male 05day    776 adult male 30day    660 adult female 01day    92 adult female 05day    43 adult female 30day    32 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    408 embryo 04-06hr    1337 embryo 06-08hr    5681 embryo 08-10hr    6988 embryo 10-12hr    6490 embryo 12-14hr    7823 embryo 14-16hr    4183 embryo 16-18hr    1482 embryo 18-20hr    1343 embryo 20-22hr    1454 embryo 22-24hr    1334 larva L1    1139 larva L2    1190 larva L3 12hr old    769 larva L3 puffstage 1-2    436 larva L3 puffstage 3-6    684 larva L3 puffstage 7-9    940 white prepupae new    2205 white prepupae 12hr    3185 white prepupae 24hr    2479 pupae 2d postWPP    853 pupae 3d postWPP    425 pupae 4d postWPP    407 adult male 01day    509 adult male 05day    776 adult male 30day    660 adult female 01day    92 adult female 05day    43 adult female 30day    32 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    408 embryo 04-06hr    1337 embryo 06-08hr    5681 embryo 08-10hr    6988 embryo 10-12hr    6490 embryo 12-14hr    7823 embryo 14-16hr    4183 embryo 16-18hr    1482 embryo 18-20hr    1343 embryo 20-22hr    1454 embryo 22-24hr    1334 larva L1    1139 larva L2    1190 larva L3 12hr old    769 larva L3 puffstage 1-2    436 larva L3 puffstage 3-6    684 larva L3 puffstage 7-9    940 white prepupae new    2205 white prepupae 12hr    3185 white prepupae 24hr    2479 pupae 2d postWPP    853 pupae 3d postWPP    425 pupae 4d postWPP    407 adult male 01day    509 adult male 05day    776 adult male 30day    660 adult female 01day    92 adult female 05day    43 adult female 30day    32 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0259750 expression level Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    408 embryo 04-06hr    1337 embryo 06-08hr    5681 embryo 08-10hr    6988 embryo 10-12hr    6490 embryo 12-14hr    7823 embryo 14-16hr    4183 embryo 16-18hr    1482 embryo 18-20hr    1343 embryo 20-22hr    1454 embryo 22-24hr    1334 larva L1    1139 larva L2    1190 larva L3 12hr old    769 larva L3 puffstage 1-2    436 larva L3 puffstage 3-6    684 larva L3 puffstage 7-9    940 white prepupae new    2205 white prepupae 12hr    3185 white prepupae 24hr    2479 pupae 2d postWPP    853 pupae 3d postWPP    425 pupae 4d postWPP    407 adult male 01day    509 adult male 05day    776 adult male 30day    660 adult female 01day    92 adult female 05day    43 adult female 30day    32 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr  (408) embryo 04-06hr  (1337) embryo 06-08hr  (5681) embryo 08-10hr  (6988) embryo 10-12hr  (6490) embryo 12-14hr  (7823) embryo 14-16hr  (4183) embryo 16-18hr  (1482) embryo 18-20hr  (1343) embryo 20-22hr  (1454) embryo 22-24hr  (1334) larva L1  (1139) larva L2  (1190) larva L3 12hr old  (769) larva L3 puffstage 1-2  (436) larva L3 puffstage 3-6  (684) larva L3 puffstage 7-9  (940) white prepupae new  (2205) white prepupae 12hr  (3185) white prepupae 24hr  (2479) pupae 2d postWPP  (853) pupae 3d postWPP  (425) pupae 4d postWPP  (407) adult male 01day  (509) adult male 05day  (776) adult male 30day  (660) adult female 01day    92 adult female 05day    43 adult female 30day    32 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    408 embryo 04-06hr    1337 embryo 06-08hr  (5681) embryo 08-10hr  (6988) embryo 10-12hr  (6490) embryo 12-14hr  (7823) embryo 14-16hr  (4183) embryo 16-18hr  1482 embryo 18-20hr    1343 embryo 20-22hr  1454 embryo 22-24hr    1334 larva L1    1139 larva L2    1190 larva L3 12hr old    769 larva L3 puffstage 1-2    436 larva L3 puffstage 3-6    684 larva L3 puffstage 7-9    940 white prepupae new  2205 white prepupae 12hr  (3185) white prepupae 24hr  (2479) pupae 2d postWPP    853 pupae 3d postWPP    425 pupae 4d postWPP    407 adult male 01day    509 adult male 05day    776 adult male 30day    660 adult female 01day    92 adult female 05day    43 adult female 30day    32 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    408 embryo 04-06hr    1337 embryo 06-08hr    5681 embryo 08-10hr    6988 embryo 10-12hr    6490 embryo 12-14hr    7823 embryo 14-16hr    4183 embryo 16-18hr    1482 embryo 18-20hr    1343 embryo 20-22hr    1454 embryo 22-24hr    1334 larva L1    1139 larva L2    1190 larva L3 12hr old    769 larva L3 puffstage 1-2    436 larva L3 puffstage 3-6    684 larva L3 puffstage 7-9    940 white prepupae new    2205 white prepupae 12hr    3185 white prepupae 24hr    2479 pupae 2d postWPP    853 pupae 3d postWPP    425 pupae 4d postWPP    407 adult male 01day    509 adult male 05day    776 adult male 30day    660 adult female 01day    92 adult female 05day    43 adult female 30day    32 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    408 embryo 04-06hr    1337 embryo 06-08hr    5681 embryo 08-10hr    6988 embryo 10-12hr    6490 embryo 12-14hr    7823 embryo 14-16hr    4183 embryo 16-18hr    1482 embryo 18-20hr    1343 embryo 20-22hr    1454 embryo 22-24hr    1334 larva L1    1139 larva L2    1190 larva L3 12hr old    769 larva L3 puffstage 1-2    436 larva L3 puffstage 3-6    684 larva L3 puffstage 7-9    940 white prepupae new    2205 white prepupae 12hr    3185 white prepupae 24hr    2479 pupae 2d postWPP    853 pupae 3d postWPP    425 pupae 4d postWPP    407 adult male 01day    509 adult male 05day    776 adult male 30day    660 adult female 01day    92 adult female 05day    43 adult female 30day    32 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0259750    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0259750 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0259750 expression level Tissue   Expression Level Larval Central Nervous System    178.475 Larval Midgut    4.6 Larval Hindgut    24.6 Larval Malpighian Tubules    4.4 Larval Fat Body    6.1 Larval Salivary Gland    7.8 Larval Trachea    56.575 Larval Carcass    238.625 Adult Head    13.6 Adult Eye    50.5 Adult Brain    103.3 Adult Thoracic-Abdominal Ganglion    71.6 Adult Crop    24.4 Adult Midgut    0.9 Adult Hindgut    3.2 Adult Malpighian Tubules    8.3 Adult Fat Body no informative data Adult Salivary Gland    3.7 Adult Heart    18.925 Adult VirginFemale Spermatheca    21.1 Adult InseminatedFemale Spermatheca    21.1 Adult Ovary    5.4 Adult Testis    9.4 Adult Male Accessory Gland    2.3 Adult Carcass    4 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    178.475 Larval Midgut    4.6 Larval Hindgut    24.6 Larval Malpighian Tubules    4.4 Larval Fat Body    6.1 Larval Salivary Gland    7.8 Larval Trachea    56.575 Larval Carcass    238.625 Adult Head    13.6 Adult Eye    50.5 Adult Brain    103.3 Adult Thoracic-Abdominal Ganglion    71.6 Adult Crop    24.4 Adult Midgut    0.9 Adult Hindgut    3.2 Adult Malpighian Tubules    8.3 Adult Fat Body no informative data Adult Salivary Gland    3.7 Adult Heart    18.925 Adult VirginFemale Spermatheca    21.1 Adult InseminatedFemale Spermatheca    21.1 Adult Ovary    5.4 Adult Testis    9.4 Adult Male Accessory Gland    2.3 Adult Carcass    4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    178.475 Larval Midgut    4.6 Larval Hindgut    24.6 Larval Malpighian Tubules    4.4 Larval Fat Body    6.1 Larval Salivary Gland    7.8 Larval Trachea    56.575 Larval Carcass    238.625 Adult Head    13.6 Adult Eye    50.5 Adult Brain    103.3 Adult Thoracic-Abdominal Ganglion    71.6 Adult Crop    24.4 Adult Midgut    0.9 Adult Hindgut    3.2 Adult Malpighian Tubules    8.3 Adult Fat Body no informative data Adult Salivary Gland    3.7 Adult Heart    18.925 Adult VirginFemale Spermatheca    21.1 Adult InseminatedFemale Spermatheca    21.1 Adult Ovary    5.4 Adult Testis    9.4 Adult Male Accessory Gland    2.3 Adult Carcass    4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    178.475 Larval Midgut    4.6 Larval Hindgut    24.6 Larval Malpighian Tubules    4.4 Larval Fat Body    6.1 Larval Salivary Gland    7.8 Larval Trachea    56.575 Larval Carcass    238.625 Adult Head    13.6 Adult Eye    50.5 Adult Brain    103.3 Adult Thoracic-Abdominal Ganglion    71.6 Adult Crop    24.4 Adult Midgut    0.9 Adult Hindgut    3.2 Adult Malpighian Tubules    8.3 Adult Fat Body no informative data Adult Salivary Gland    3.7 Adult Heart    18.925 Adult VirginFemale Spermatheca    21.1 Adult InseminatedFemale Spermatheca    21.1 Adult Ovary    5.4 Adult Testis    9.4 Adult Male Accessory Gland    2.3 Adult Carcass    4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0259750 expression level Tissue   Expression Level Larval Central Nervous System    178.475 Larval Midgut    4.6 Larval Hindgut    24.6 Larval Malpighian Tubules    4.4 Larval Fat Body    6.1 Larval Salivary Gland    7.8 Larval Trachea    56.575 Larval Carcass    238.625 Adult Head    13.6 Adult Eye    50.5 Adult Brain    103.3 Adult Thoracic-Abdominal Ganglion    71.6 Adult Crop    24.4 Adult Midgut    0.9 Adult Hindgut    3.2 Adult Malpighian Tubules    8.3 Adult Fat Body no informative data Adult Salivary Gland    3.7 Adult Heart    18.925 Adult VirginFemale Spermatheca    21.1 Adult InseminatedFemale Spermatheca    21.1 Adult Ovary    5.4 Adult Testis    9.4 Adult Male Accessory Gland    2.3 Adult Carcass    4 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    178.475 Larval Midgut    4.6 Larval Hindgut    24.6 Larval Malpighian Tubules    4.4 Larval Fat Body    6.1 Larval Salivary Gland    7.8 Larval Trachea    56.575 Larval Carcass    238.625 Adult Head    13.6 Adult Eye    50.5 Adult Brain    103.3 Adult Thoracic-Abdominal Ganglion    71.6 Adult Crop    24.4 Adult Midgut    0.9 Adult Hindgut    3.2 Adult Malpighian Tubules    8.3 Adult Fat Body no informative data Adult Salivary Gland    3.7 Adult Heart    18.925 Adult VirginFemale Spermatheca    21.1 Adult InseminatedFemale Spermatheca    21.1 Adult Ovary    5.4 Adult Testis    9.4 Adult Male Accessory Gland    2.3 Adult Carcass    4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    178.475 Larval Midgut    4.6 Larval Hindgut    24.6 Larval Malpighian Tubules    4.4 Larval Fat Body    6.1 Larval Salivary Gland    7.8 Larval Trachea    56.575 Larval Carcass    238.625 Adult Head    13.6 Adult Eye    50.5 Adult Brain    103.3 Adult Thoracic-Abdominal Ganglion    71.6 Adult Crop    24.4 Adult Midgut    0.9 Adult Hindgut    3.2 Adult Malpighian Tubules    8.3 Adult Fat Body no informative data Adult Salivary Gland    3.7 Adult Heart    18.925 Adult VirginFemale Spermatheca    21.1 Adult InseminatedFemale Spermatheca    21.1 Adult Ovary    5.4 Adult Testis    9.4 Adult Male Accessory Gland    2.3 Adult Carcass    4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    178.475 Larval Midgut    4.6 Larval Hindgut    24.6 Larval Malpighian Tubules    4.4 Larval Fat Body    6.1 Larval Salivary Gland    7.8 Larval Trachea    56.575 Larval Carcass    238.625 Adult Head    13.6 Adult Eye    50.5 Adult Brain    103.3 Adult Thoracic-Abdominal Ganglion    71.6 Adult Crop    24.4 Adult Midgut    0.9 Adult Hindgut    3.2 Adult Malpighian Tubules    8.3 Adult Fat Body no informative data Adult Salivary Gland    3.7 Adult Heart    18.925 Adult VirginFemale Spermatheca    21.1 Adult InseminatedFemale Spermatheca    21.1 Adult Ovary    5.4 Adult Testis    9.4 Adult Male Accessory Gland    2.3 Adult Carcass    4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    13.6   NA  Eye    50.5   NA  Brain    103.3   178.475  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    71.6   NA  Crop    24.4   4.6  Midgut    0.9   24.6  Hindgut    3.2   4.4  Malpighian Tubules    8.3   6.1  Fat Body    no informative data   7.8  Salivary Gland    3.7   NA  Heart    18.925   56.575  Trachea    NA   NA  VirginFemale Spermatheca    21.1   NA  InseminatedFemale Spermatheca    21.1   NA  Ovary    5.4   NA  Testis    9.4   NA  Male Accessory Gland    2.3   238.625  Carcass    4 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_11
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259750
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage ab26 lethal | first instar larval stage abclu-1 lethal | first instar larval stage (with abclu-1) abk02807 lethal | first instar larval stage (with abk02807) abclu-1 lethal | pupal stage, with Scer\GAL4pnr-MD237 abGD4062 lethal | pupal stage | recessive ab60M abG9 lethal | recessive abclu-1 abclu2 abclu3 abk02807 semi-lethal | recessive abl-60h viable abEY09709 viable (with ab1) ab26 abclu-1 viable (with ab26) ab1 viable (with abclu-1) ab1 Sterility Allele fertile abEY09709 male sterile | recessive ab1 ab1D ab2 ab51g ab60M abG9 Other Phenotypes Allele neuroanatomy defective abclu-1 abk02807 neuroanatomy defective, with Scer\GAL4109(2)80 abScer\UAS.cBa neuroanatomy defective, with Scer\GAL4109(2)80, Scer\GAL4IG1-2 abScer\UAS.L.cSa abScer\UAS.S.cSa neuroanatomy defective (with abclu-1) abk02807 neuroanatomy defective (with abk02807) abclu-1 neuroanatomy defective | semidominant ab26 neuroanatomy defective | somatic clone ab26 visible, with Scer\GAL4dpp.blk1 abB2149 abScer\UAS.cGa visible | dominant ab1D abclu-1 visible | recessive ab2 ab51g abl-60h visible | recessive | cold sensitive ab1 wild-type abBL97 Phenotype manifest in Allele abdominal 2 dorsal acute muscle 3 ab1D abG5 abclu-1 abclu2 abclu3 abdominal 2 dorsal oblique muscle 3 ab1D abG5 abclu-1 abclu2 abclu3 abdominal 2 dorsal oblique muscle 5 ab1D abG5 abclu-1 abclu2 abclu3 abdominal 2 lateral oblique muscle 1 ab1D abG5 abclu-1 abclu2 abclu3 abdominal 3 dorsal acute muscle 3 ab1D abG5 abclu-1 abclu2 abclu3 abdominal 3 dorsal oblique muscle 3 ab1D abG5 abclu-1 abclu2 abclu3 abdominal 3 dorsal oblique muscle 5 ab1D abG5 abclu-1 abclu2 abclu3 abdominal 3 lateral oblique muscle 1 ab1D abG5 abclu-1 abclu2 abclu3 abdominal 4 dorsal acute muscle 3 ab1D abG5 abclu-1 abclu2 abclu3 abdominal 4 dorsal oblique muscle 3 ab1D abG5 abclu-1 abclu2 abclu3 abdominal 4 dorsal oblique muscle 5 ab1D abG5 abclu-1 abclu2 abclu3 abdominal 4 lateral oblique muscle 1 ab1D abG5 abclu-1 abclu2 abclu3 abdominal 5 dorsal acute muscle 3 ab1D abG5 abclu-1 abclu2 abclu3 abdominal 5 dorsal oblique muscle 3 ab1D abG5 abclu-1 abclu2 abclu3 abdominal 5 dorsal oblique muscle 5 ab1D abG5 abclu-1 abclu2 abclu3 abdominal 5 lateral oblique muscle 1 ab1D abG5 abclu-1 abclu2 abclu3 abdominal 6 dorsal acute muscle 3 ab1D abG5 abclu-1 abclu2 abclu3 abdominal 6 dorsal oblique muscle 3 ab1D abG5 abclu-1 abclu2 abclu3 abdominal 6 dorsal oblique muscle 5 ab1D abG5 abclu-1 abclu2 abclu3 abdominal 6 lateral oblique muscle 1 ab1D abG5 abclu-1 abclu2 abclu3 abdominal 7 dorsal acute muscle 3 ab1D abG5 abclu-1 abclu2 abclu3 abdominal 7 dorsal oblique muscle 3 ab1D abG5 abclu-1 abclu2 abclu3 abdominal 7 dorsal oblique muscle 5 ab1D abG5 abclu-1 abclu2 abclu3 abdominal 7 lateral oblique muscle 1 ab1D abG5 abclu-1 abclu2 abclu3 abdominal posterior ventral multidendritic neuron vdap abclu-1 abk02807 abKG05262 ab26 abdominal posterior ventral multidendritic neuron vdap, with Scer\GAL4221 abScer\UAS.cBa abdominal posterior ventral multidendritic neuron vdap (with abclu-1) abk02807 abdominal posterior ventral multidendritic neuron vdap (with abk02807) abclu-1 abdominal segmental nerve ab1D abG5 abclu-1 abclu2 abclu3 abdominal transverse nerve ab1D abG5 abclu-1 abclu2 abclu3 arista, with Scer\GAL4dpp.blk1 abB2149 abScer\UAS.cGa autophagic vacuole & larval fat body | somatic clone | cell autonomous abk02807 bipolar dendrite neuron | somatic clone ab26 border follicle cell, with Scer\GAL4c306 abEY09709 border follicle cell, with Scer\GAL4slbo.2.6 abScer\UAS.cUa coxa ab2 ab51g dorsal double row ab1 dorsal multidendritic neuron, with Scer\GAL4109(2)80 abScer\UAS.cBa dorsal multidendritic neuron ddaA, with Scer\GAL4109(2)80, Scer\GAL4IG1-2 abScer\UAS.L.cSa abScer\UAS.S.cSa dorsal multidendritic neuron ddaB, with Scer\GAL4109(2)80, Scer\GAL4IG1-2 abScer\UAS.L.cSa dorsal multidendritic neuron ddaC, with Scer\GAL4109(2)80, Scer\GAL4IG1-2 abScer\UAS.L.cSa dorsal multidendritic neuron ddaC, with Scer\GAL4477 abScer\UAS.cBa dorsal multidendritic neuron ddaD abk02807 dorsal multidendritic neuron ddaD | somatic clone abclu-1 abk02807 dorsal multidendritic neuron ddaE abclu-1 abk02807 dorsal multidendritic neuron ddaE, with Scer\GAL4221 abScer\UAS.cBa dorsal multidendritic neuron ddaE (with ab1) ab26 dorsal multidendritic neuron ddaE (with ab26) ab1 dorsal multidendritic neuron ddaE (with abclu-1) abk02807 dorsal multidendritic neuron ddaE (with abk02807) abclu-1 dorsal multidendritic neuron ddaE | somatic clone abclu-1 abk02807 ab26 dorsal multidendritic neuron ddaF | somatic clone ab26 female germline cell | somatic clone | supernumerary, with Scer\GAL4Act.PU abScer\UAS.cBa germline cell | supernumerary | heat sensitive, with Scer\GAL4ptc-559.1, Scer\GAL80ts.αTub84B abScer\UAS.cBa leg ab1 leg, with Scer\GAL4dpp.blk1 abB2149 leg (with ab1) ab1D leg (with ab1D) ab1 leg (with ab60M) abG9 leg (with abG9) ab60M lysosome & larval fat body | somatic clone | cell autonomous abk02807 macrochaeta, with Scer\GAL4dpp.blk1 abB2149 macrochaeta & wing ab1 macrochaeta & wing (with ab1) ab1D macrochaeta & wing (with ab1D) ab1 macrochaeta & wing (with ab60M) abG9 macrochaeta & wing (with abG9) ab60M macrochaeta | supernumerary, with Scer\GAL4dpp.blk1 abB2149 male genitalia ab1 ab2 ab51g male genitalia (with ab1) ab1D male genitalia (with ab1D) ab1 male genitalia (with ab60M) abG9 male genitalia (with abG9) ab60M mechanosensory ventral triple row bristle ab1 medial triple row ab1 microchaeta & abdomen ab2 ab51g microchaeta & thorax ab2 ab51g mitochondrion & larval fat body | somatic clone | cell autonomous abk02807 posterior crossvein ab1 abM1 posterior scutellar bristle ab1 scutellar bristle ab2 ab51g sensillum campaniformium of anterior crossvein ab1 abM1 sensillum campaniformium of dorsal radius ab1 abM1 sensillum campaniformium of dorsal radius (with ab1) ab1D sensillum campaniformium of dorsal radius (with ab1D) ab1 sensillum campaniformium of dorsal radius (with ab60M) abG9 sensillum campaniformium of dorsal radius (with abG9) ab60M supraalar bristle ab2 ab51g transverse nerve abclu-1 ventral double row ab1 wing ab1D abclu-1 wing vein (with ab1) ab1D wing vein (with ab1D) ab1 ab94 wing vein (with ab60M) abG9 wing vein (with ab94) ab1D wing vein (with abG9) ab60M wing vein | cell non-autonomous | ectopic | somatic clone, with Scer\GAL4Ubx.PdC abScer\UAS.cBa wing vein L5 ab1 ab2 ab51g ab94 abM1 abl-60h wing vein L5 (with ab1) abclu-1 wing vein L5 (with abclu-1) ab1 wing vein L5 | cold sensitive ab1
Classical Alleles ( 36 )
For All Classical Alleles Show
Allele of ab Class Mutagen Stocks Known lesion ab2 spontaneous 6 -- abk02807 P-element activity 3 -- ab1 spontaneous 2 -- abKG05262 P-element activity 2 -- ab1D amorphic allele - genetic evidence Delta2-3 1 Yes ab5-HA-2891 1 -- abc04102 piggyBac transposase 1 -- abc06804 piggyBac transposase 1 -- abclu-1 ethyl methanesulfonate 1 Yes abe01874 piggyBac transposase 1 -- abe02159 piggyBac transposase 1 -- abEY01129 P-element activity 1 -- abEY09709 P-element activity 1 -- abf02245 piggyBac transposase 1 -- abf04146 piggyBac transposase 1 -- abf06303 piggyBac transposase 1 -- abMI01579 1 -- abNP1107 1 -- abG5 amorphic allele - genetic evidence gamma ray 0 Yes ab26 ethyl methanesulfonate 0 Yes ab51g spontaneous 0 -- ab60M gamma ray 0 -- ab94 P-element activity 0 -- abB2149 0 Yes abBL97 P-element activity 0 -- abc05455 piggyBac transposase 0 -- abclu2 ethyl methanesulfonate 0 Yes abclu3 ethyl methanesulfonate 0 -- abCPTI004479 piggyBac transposase 0 Yes abf05597 piggyBac transposase 0 -- abG9 gamma ray 0 -- abl-60h spontaneous 0 -- abM1 0 -- abNP2225 0 -- abSH2025 0 -- abunspecified 0 --
Alleles Carried on Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Allele of ab Class Mutagen Stocks Known lesion abGD4062 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes abHMS00369 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes abJF03343 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes abKK110195 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes abScer\UAS.cBa in vitro construct - regulatory fusion 1 Yes abdsRNA.cDa in vitro construct - RNAi 0 Yes abdsRNA.cDb in vitro construct - RNAi 0 Yes abScer\UAS.cGa in vitro construct - regulatory fusion 0 Yes abScer\UAS.cUa in vitro construct - regulatory fusion 0 Yes abScer\UAS.L.cSa in vitro construct - regulatory fusion 0 Yes abScer\UAS.S.cSa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)BSC241 (Christensen and Cook, 2006.12.5) Df(2L)BSC242 (Christensen and Cook, 2008.4.15) Df(2L)BSC343 (Christensen and Cook, 2007.10.29) Df(2L)Exel6028 (Ryder, 2004.4.26) Df(2L)FCK-20 (Li et al., 2004)
Not disrupted in	Df(2L)Prl (BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4062} NA P{KK110195} NA P{TRiP.HMS00369} NA P{TRiP.JF03343} NA P{UAS-ab.B} NA P{UAS-ab.G} NA P{UAS-ab.L} NA P{UAS-ab.S} NA P{UAS-ab.U} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}abEY01129 NA P{EPgy2}abEY09709 NA P{GSV1}EP-179EP-179 NA P{GSV1}GSd324GSd324 NA P{Mae-UAS.6.11}abB2149 NA miscellaneous insertions Mi{MIC}abMI01579 NA P{RS5}ab5-HA-2891 NA P{SUPor-P}abKG05262 NA PBac{810.P.FSVS-2}abCPTI004479 NA PBac{PB}abc04102 NA PBac{PB}abc05455 NA PBac{PB}abc06804 NA PBac{RB}abe01874 NA PBac{RB}abe02159 NA PBac{WH}abf02245 NA PBac{WH}abf04146 NA PBac{WH}abf05597 NA PBac{WH}abf06303 NA insertion of enhancer trap P{A92}abBL97 No P{lacW}abk02807 No P{lacW}abSH2025 No P{lacW}l(2)SH0770SH0770 No P{lwB}ab1D No P{lwB}ab94 No insertion of enhancer trap binary system P{GawB}abNP1107 No P{GawB}abNP2225 No
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
border follicle cell migration inferred from mutant phenotype (Jang et al., 2009) dendrite morphogenesis inferred from mutant phenotype (Sugimura et al., 2004, Li et al., 2004, Parrish et al., 2006) muscle organ development inferred from mutant phenotype (Parrish et al., 2006) neuron development inferred from mutant phenotype (Parrish et al., 2006)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity with EMBL:AF032676 (FlyBase, 1992-) zinc ion binding inferred from electronic annotation with InterPro:IPR007087, InterPro:IPR015880 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
axon choice point recognition traceable author statement (Chiba, 1999)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with EMBL:AF032676 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	gene (Grieder et al., 2007) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions ab allele Gene References ab1 bi (Cook et al., 2004) N (Thompson et al., 1988) Snr1 (Marenda et al., 2004) unspecified Bap55 (Parrish et al., 2006) ct (Sugimura et al., 2004) HmgD (Parrish et al., 2006) rho (Sturtevant and Bier, 1995) sens (Parrish et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60620 DroID - A comprehensive database of gene and protein interactions. • FBgn0259750 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34560
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14766 Dere\GG23712 Dgri\GH13387 Dmoj\GI20650 Dper\GL19550 Dsec\GM18962 Dsim\ab Dvir\GJ13245 Dwil\GK14898 Dyak\ab
Curated drosophilid orthologs	Dpse\GA18447   Dpse\inc (Sturtevant and Novitski, 1941, Sturtevant and Tan, 1937)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL002008-PA Aedes aegypti (mosquito) AGAP008032-PA Anopheles gambiae (mosquito) XP_001122274.1 Apis mellifera (honey bee) BGIBMGA003766-PA Bombyx mori (silk worm) ENSBTAP00000004465 Bos taurus (bovine) ENSCAFP00000029905 Canis familiaris (dog) ENSCINP00000020104 Ciona intestinalis (sea squirt) CPIJ006343 Culex pipens (mosquito) ENSCPOP00000000787 Cavia porcellus (guinea pig) ENSECAP00000010928 Equus caballus (horse) ENSGACP00000017893 Gymnopilus aculeatus (mushroom) ENSGALP00000007304 Gallus gallus (chicken) ENSP00000308759 Homo sapiens (human) ENSMODP00000030484 Monodelphis domestica (gray opossum) XP_001601763.1 Nasonia vitripennis (wasp) ENSOANP00000023224 Ornithorynchus anatinus (platypus) ENSORLP00000017660 Oryzias latipes (japanese killifish) ENSPPYP00000012774 Pongo pygmaeus (orangutan) ENSPTRP00000000851 Pan troglodytes (chimpanzee) ENSRNOP00000027323 Rattus norvegicus (norway rat) XP_973130.1 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0235930 FBgn0200471 FBgn0195143 FBgn0173865 FBgn0247381 FBgn0115853 FBgn0091793 AGAP008032
Stocks & Reagents
Stocks Listed in FlyBase ( 32 )
Bloomington	203 ab1 23639 w*; P{UAS-ab.B}55
Harvard	- PBac{PB}abc04102 - PBac{PB}abc06804 - PBac{RB}abe01874 - PBac{RB}abe02159 - PBac{WH}abf02245 - PBac{WH}abf04146 - PBac{WH}abf06303
Kyoto	105785 ab1
VDRC	v104582 P{KK110195}VIE-260B v41005 w1118; P{GD4062}v41005
	More stocks available...
Genomic Clones ( 1 )
	BACR09F02 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 100 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT11330 IP14443 RE25924
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT14704 LD07509 LP05458 LP11514 LP21051 RH18250 RH19751 RH20126 RH66579
Other clones	8761 12854 13206 18339 30925 45732 52569 55371 55763 58427 72275 75980 76309 82119 103046 106475 118996 161171 166599 176016 176297 177501 240822 CK01.10C.C12 CK01.27D.C12 CK01.58C.G10 CK01.62B.H5 CK01.82B.D5 CK01.85D.C12 CK01.88B.D11 CK01.100B.G10 CK01.106C.F12 CK01.115D.E6 CK01.116C.A6 CK01.169C.H7 CK00361 CK01042 CK02570 Dmel_neb_015363_0832_2468 EC256810 EK004551 EK010003 EK042304 EK047657 EK050024 EK067942 EK069614 EK088944 EK089154 EK103932 EK107521 EK114119 EK114750 EK124103 EK130956 EK141211 EK157704 EK161858 EK164934 EK166821 EK181316 EK182259 EK183911 EK200825 EK224324 EK231944 EK238612 EK264957 EK271225 EK281344 EK282652 EK290161 EN17428 EP03431 IP14543 IP14743 RP004016277 RP004083771 RP004104513 RP004152647 RP004211956 RP004255728 RP004302157 RP004406836 RP004422247 RP004446947 RP004487486 RP004547284
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0259750 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34560
Antibody Information
	polyclonal (Hu et al., 1995)
Other Information
Discoverer
	Bridges, 16th Oct. 1916.
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: ab CG4807 (Zhong, 1999.11)
Source for database merge of	Source for merge of: ab B2149 (Grieder et al., 2007)
Additional comments
Other Comments
	ab is a repressor of ecdysone signalling and border follicle cell migration. (Jang et al., 2009) dsRNA has been made from templates generated with primers directed against this gene. ab RNAi causes an increase in dendrite arborization of ddaD and ddaE neurons. There is an increase in the number and length of lateral branches, which results in an expansion of the coverage field, most noticeably along the anteroposterior (AP) axis. In addition to these defects,ab RNAi also causes frequent cell death, defects in muscle, alterations in the number of MD neurons, defects in dendrite morphogenesis and reproducible defects in da dendrite development. (Parrish et al., 2006) P-element excision and γ ray induced lethal mutations of the enhancer trap BL97 fail to complement ab. (Hu et al., 1995) ab encodes a BTB-zinc finger regulatory protein that controls the specificity of neuromuscular connections. (Hu et al., 1995) Loss of vein mutations cause suppression of rhohs.PSt ectopic vein phenotype and enhancement of the rhove-1 loss of vein phenotype. (Sturtevant and Bier, 1995) Identification: Mutations affecting neuromuscular connectivity, using an antibody to Fas2. (van Vactor et al., 1993) Mutations in ab affect individual longitudinal veins: vein specific effects. (Diaz-Benjumea and Garcia-Bellido, 1990) kni, tg, tt, ab, cv, cv-2, cv-c and cv-d belong to the radius incompletus phenotypic group within the 'lack-of-vein' mutant class. Loss-of-function alleles at these loci remove stretches of veins in two or more longitudinal veins. Double mutants of this group have additive phenotypes suggesting the genes are vein-specific, and small lanceolate wings. Therefore involved in whole vein-region specification rather than vein differentiation. ab alleles may have pleiotropic effects on leg development or be embryonic lethal. (Diaz-Benjumea et al., 1989) Loss of function is lethal, with effects on connectivity of segmental nerves; hypomorphic alleles affect the development of wing veins, especially wing vein L5, with effects in coxa, male genitalia and bristles.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057214 NM_057215 NM_001169480 NM_001169481 RefSeq (Proteins) • NP_476562 NP_476563 NP_001162951 NP_001162952 DDBJ / EMBL / GenBank • AAA86639 AAF53087 AAN10774 AAN71338 AC006073 AC092241 ACZ94238 ACZ94239 AQ025716 BF497208 BI228386 BT001583 CL528185 CZ468985 CZ468986 CZ469995 CZ471000 CZ479690 CZ479691 CZ479987 CZ484753 CZ486675 CZ488198 CZ488989 U43733 Entrez Gene - A searchable database of RefSeq genes. • 34560 UniProtKB/Swiss-Prot • Q24174
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • BTB/POZ-like (IPR000210) Zinc finger, C2H2 (IPR007087) BTB/POZ (IPR013069) BTB/POZ fold (IPR011333) Zinc finger, C2H2-like (IPR015880)
Linkouts
	BioGRID - A database of protein and genetic interactions • 60620 DroID - A comprehensive database of gene and protein interactions. • FBgn0259750 DRSC - Results from RNAi screens. • FBgn0259750 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259750 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0259750 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34560 InParanoid A subset of ortholog calls from InParanoid. • AAEL002008-PA Aedes aegypti (mosquito) AGAP008032-PA Anopheles gambiae (mosquito) XP_001122274.1 Apis mellifera (honey bee) BGIBMGA003766-PA Bombyx mori (silk worm) ENSBTAP00000004465 Bos taurus (bovine) ENSCAFP00000029905 Canis familiaris (dog) ENSCINP00000020104 Ciona intestinalis (sea squirt) CPIJ006343 Culex pipens (mosquito) ENSCPOP00000000787 Cavia porcellus (guinea pig) ENSECAP00000010928 Equus caballus (horse) ENSGACP00000017893 Gymnopilus aculeatus (mushroom) ENSGALP00000007304 Gallus gallus (chicken) ENSP00000308759 Homo sapiens (human) ENSMODP00000030484 Monodelphis domestica (gray opossum) XP_001601763.1 Nasonia vitripennis (wasp) ENSOANP00000023224 Ornithorynchus anatinus (platypus) ENSORLP00000017660 Oryzias latipes (japanese killifish) ENSPPYP00000012774 Pongo pygmaeus (orangutan) ENSPTRP00000000851 Pan troglodytes (chimpanzee) ENSRNOP00000027323 Rattus norvegicus (norway rat) XP_973130.1 Tribolium castaneum (red flour beetle) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /neural/abrupt.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34560 modMine - Data generated by the modENCODE project. • FBgn0259750 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0235930 FBgn0200471 FBgn0195143 FBgn0173865 FBgn0247381 FBgn0115853 FBgn0091793 AGAP008032
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	ab (Hattori et al., 2007, Li et al., 2004, Stark et al., 2005, Dorner et al., 2006, Christensen and Cook, 2006.12.5, Sugimura et al., 2004, Crews and Brenman, 2006, Kim et al., 2006, Cook, 2006.6.12, Zhang et al., 2006, Christensen and Cook, 2007.10.29, Quinones-Coello, 2007, Caygill and Johnston, 2008, Cook et al., 2008, Molnar et al., 2006, Grieder et al., 2007, Christensen and Cook, 2008.4.15, Brodsky et al., 2004, Minidorff et al., 2007, Spokony and Restifo, 2007, Caygill and Johnston, 2008, Franciscovich et al., 2008, Arsham and Neufeld, 2009, Zeitlinger et al., 2007, Long et al., 2009, Komiyama and Luo, 2007, Pilgram et al., 2011, König et al., 2011, Cunha et al., 2010) Ab (Shimono et al., 2009) B2149   CG4807 (Whitfield, 2001.10.8, Quinones-Coello, 2007, Molnar et al., 2006, Grieder et al., 2007, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2010.12.1) clu (Bate and Broadie, 1995, Seeger, 1994, van Vactor et al., 1993, Caygill and Johnston, 2008) l(2)k02807   ptd
Name Synonym	Abrupt (Hattori et al., 2007, Parrish et al., 2006, Jang et al., 2009, Long et al., 2009, Shimono et al., 2009) abrupt (Li et al., 2004, Sugimura et al., 2004, Sahota et al., 2007, Crews and Brenman, 2006, Caygill and Johnston, 2008, Cook et al., 2008, Grieder et al., 2007, Spokony and Restifo, 2007, Caygill and Johnston, 2008, Parrish et al., 2007, Sharma et al., 2011) clueless (Wilson, 1993, Broadie et al., 1993, Goodman and Doe, 1993, Caygill and Johnston, 2008) parted
Secondary FlyBase IDs
	FBgn0000011 FBgn0013436 FBgn0022233 FBgn0259599
References ( 109 )
Generate a list of	All references relating to this gene ( 109 )
List References by type	Research paper  ( 45 ) Supplementary material  ( 8 ) Review  ( 18 ) Personal communication to FlyBase  ( 15 ) Abstract  ( 9 ) FlyBase analysis  ( 3 ) Curated genome annotation  ( 1 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 4 ) Automatic genome annotation  ( 1 ) Book  ( 3 ) Spoof  ( 1 )
Recent research papers ( 5 )
	König et al., 2011, EMBO J. 30(8): 1549--1562 Ecdysteroids affect Drosophila ovarian stem cell niche formation and early germline differentiation. [FBrf0213531] Pilgram et al., 2011, J. Neurosci. 31(2): 492--500 The RhoGAP crossveinless-c Interacts with Dystrophin and Is Required for Synaptic Homeostasis at the Drosophila Neuromuscular Junction. [FBrf0212767] Sharma et al., 2011, Chemosphere 82(3): 370--376 Transcriptome analysis provides insights for understanding the adverse effects of endosulfan in Drosophila melanogaster. [FBrf0212610] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Cunha et al., 2010, PLoS Genet. 6: e1001014 Combinatorial binding leads to diverse regulatory responses: Lmd is a tissue-specific modulator of Mef2 activity. [FBrf0211225] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...