• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\pzg

General Information
Symbol	Dmel\pzg	Species	D. melanogaster
Name	putzig	Annotation symbol	CG7752
Feature type	protein_coding_gene	FlyBase ID	FBgn0259785
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	Z4, p160
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	78C5-78C6	Sequence location	3L:21,279,199..21,283,410 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene putzig is referred to in FlyBase by the symbol Dmel\pzg (CG7752, FBgn0259785). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: chromatin binding. There is experimental evidence that it is involved in the biological process: ecdysone receptor-mediated signaling pathway; negative regulation of JAK-STAT cascade; positive regulation of Notch signaling pathway; chromosome organization; cell cycle; neurogenesis. 18 alleles are reported. The phenotypes of these alleles are annotated with: eye; polytene chromosome; embryonic/larval salivary gland; polytene chromosome band; mesothoracic tergum; wing. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Zinc finger, C2H2; Zinc finger, C2H2-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval/adult salivary gland, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1630682_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of pzg. Gene sequence location is 3L:21279199..21283410.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 78C5-78C6   Limits computationally determined from genome sequence between P{PZ}ppl00217 and P{lacW}l(3)j1B10j1B10
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\pzg for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Low-frequency RNA-seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) pzg-RA FBtr0078336  NM_141040   4093   996 pzg-RB FBtr0331793  NM_001275214   3824   996
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein pzg-PA   FBpp0077992   105.1   996   4.54     NP_649297   AAF51699 pzg-PB   FBpp0304178   105.1   996   4.54     NP_001262143   AGB94836
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2-like (IPR015880) Zinc finger, C2H2 (IPR007087)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202168   AA202199   AA202522   AA202694   AA202948   AA246671   AA246749   AA264174   AA264859   AA390323   AA390559   AA392102   AA392438   AA438576   AA438913   AA439140   AA439323   AA440859   AA538618   AA539627   AA694755   AA816578   AA816955   AA817021   AA940681   AA940698   AA941831   AA942400   AA948955   AA949413   AA949892   AA950948   AA951051   AA951277   AA951497   AA951859   AA978938   AA979365   AA990711   AE014296 AAF51699   AE014296 AGB94836   AI062478   AI297650   AI386876   AI456318   AI457064   AI511621   AI512000   AI512412   AI514702   AI515353   AI518102   AI518710   AI520258   AI520268   AI520472   AI531788   AI532729   AI533019   AI533410   AI533481   AI542145   AI542474   AI543917   AI544088   AI546169   AW942384   BG638037   BI166825   BI167990   BI168650   BI169849   BI212614   BI213576   BI214951   BI216047   BI231616   BI232295   BI232307   BI235264   BI236208   BI237339   BI239204   BI353038   BI353196   BI356594   BI364290   BI365045   BI365236   BI365876   BI367951   BI367972   BI369291   BI373374   BI481879   BI486057   BI486124   BI577647   BI578562   BI579967   BI580712   BI580854   BI633228   BI637311   BI638534   BI639498   BI639847   BP553417   BT010057 AAQ22526   CK605353   CK605354   CK661808   CL868468   CO187539   CO264363   CO266996   CO270849   CO271354   CO277178   CO277535   CO285298   CO292465   CO295733   CO304064   CO309956   CO314798   CO333344   CO337358   CO339940   CZ466326   CZ468192   CZ470424   CZ470425   EC061633   EC067244   EC071366   EC071577   EC073842   EC083146   EC083708   EC086578   EC088377   EC195078   EC197832   EC202012   EC202212   EC222667   EC223593   EC229491   EC232689   EC239668   EC239871   EC244273   EC246067   EC247417   EC266107   EV592878   EV595368
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VP57
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   antennal anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage central brain anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage dorsal head epidermis anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage visual anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage organism | ubiquitous   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   antennal primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium organism | ubiquitous   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   central brain primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleus inferred from direct assay (Kugler and Nagel, 2007, Eggert et al., 2004) NURF complex inferred from physical interaction with E(bx), Iswi, Caf1, Nurf-38 (Kugler and Nagel, 2010) polytene chromosome interband inferred from direct assay (Eggert et al., 2004, Gortchakov et al., 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval/adult salivary gland, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    256.1 Larval Midgut    63.3 Larval Hindgut    62.7 Larval Malpighian Tubules    52.3 Larval Fat Body    52.4 Larval Salivary Gland    108.1 Larval Trachea    86.425 Larval Carcass    74.85 Adult Head    99.6 Adult Eye    66.95 Adult Brain    222.9 Adult Thoracic-Abdominal Ganglion    143 Adult Crop    55.3 Adult Midgut    76.7 Adult Hindgut    63.2 Adult Malpighian Tubules    49.2 Adult Fat Body    83.9 Adult Salivary Gland    108.8 Adult Heart    40.775 Adult VirginFemale Spermatheca    66.3 Adult InseminatedFemale Spermatheca    76.5 Adult Ovary    69.6 Adult Testis    19.7 Adult Male Accessory Gland    206.6 Adult Carcass    74.4 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    256.1 Larval Midgut    63.3 Larval Hindgut    62.7 Larval Malpighian Tubules    52.3 Larval Fat Body    52.4 Larval Salivary Gland    108.1 Larval Trachea    86.425 Larval Carcass    74.85 Adult Head    99.6 Adult Eye    66.95 Adult Brain    222.9 Adult Thoracic-Abdominal Ganglion    143 Adult Crop    55.3 Adult Midgut    76.7 Adult Hindgut    63.2 Adult Malpighian Tubules    49.2 Adult Fat Body    83.9 Adult Salivary Gland    108.8 Adult Heart    40.775 Adult VirginFemale Spermatheca    66.3 Adult InseminatedFemale Spermatheca    76.5 Adult Ovary    69.6 Adult Testis    19.7 Adult Male Accessory Gland    206.6 Adult Carcass    74.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    256.1 Larval Midgut    63.3 Larval Hindgut    62.7 Larval Malpighian Tubules    52.3 Larval Fat Body    52.4 Larval Salivary Gland    108.1 Larval Trachea    86.425 Larval Carcass    74.85 Adult Head    99.6 Adult Eye    66.95 Adult Brain    222.9 Adult Thoracic-Abdominal Ganglion    143 Adult Crop    55.3 Adult Midgut    76.7 Adult Hindgut    63.2 Adult Malpighian Tubules    49.2 Adult Fat Body    83.9 Adult Salivary Gland    108.8 Adult Heart    40.775 Adult VirginFemale Spermatheca    66.3 Adult InseminatedFemale Spermatheca    76.5 Adult Ovary    69.6 Adult Testis    19.7 Adult Male Accessory Gland    206.6 Adult Carcass    74.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    256.1 Larval Midgut    63.3 Larval Hindgut    62.7 Larval Malpighian Tubules    52.3 Larval Fat Body    52.4 Larval Salivary Gland    108.1 Larval Trachea    86.425 Larval Carcass    74.85 Adult Head    99.6 Adult Eye    66.95 Adult Brain    222.9 Adult Thoracic-Abdominal Ganglion    143 Adult Crop    55.3 Adult Midgut    76.7 Adult Hindgut    63.2 Adult Malpighian Tubules    49.2 Adult Fat Body    83.9 Adult Salivary Gland    108.8 Adult Heart    40.775 Adult VirginFemale Spermatheca    66.3 Adult InseminatedFemale Spermatheca    76.5 Adult Ovary    69.6 Adult Testis    19.7 Adult Male Accessory Gland    206.6 Adult Carcass    74.4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    256.1 Larval Midgut    63.3 Larval Hindgut    62.7 Larval Malpighian Tubules    52.3 Larval Fat Body    52.4 Larval Salivary Gland    108.1 Larval Trachea    86.425 Larval Carcass    74.85 Adult Head    99.6 Adult Eye    66.95 Adult Brain    222.9 Adult Thoracic-Abdominal Ganglion    143 Adult Crop    55.3 Adult Midgut    76.7 Adult Hindgut    63.2 Adult Malpighian Tubules    49.2 Adult Fat Body    83.9 Adult Salivary Gland    108.8 Adult Heart    40.775 Adult VirginFemale Spermatheca    66.3 Adult InseminatedFemale Spermatheca    76.5 Adult Ovary    69.6 Adult Testis    19.7 Adult Male Accessory Gland    206.6 Adult Carcass    74.4 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    256.1 Larval Midgut    63.3 Larval Hindgut    62.7 Larval Malpighian Tubules    52.3 Larval Fat Body    52.4 Larval Salivary Gland    108.1 Larval Trachea    86.425 Larval Carcass    74.85 Adult Head    99.6 Adult Eye    66.95 Adult Brain    222.9 Adult Thoracic-Abdominal Ganglion    143 Adult Crop    55.3 Adult Midgut    76.7 Adult Hindgut    63.2 Adult Malpighian Tubules    49.2 Adult Fat Body    83.9 Adult Salivary Gland    108.8 Adult Heart    40.775 Adult VirginFemale Spermatheca    66.3 Adult InseminatedFemale Spermatheca    76.5 Adult Ovary    69.6 Adult Testis    19.7 Adult Male Accessory Gland    206.6 Adult Carcass    74.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    256.1 Larval Midgut    63.3 Larval Hindgut    62.7 Larval Malpighian Tubules    52.3 Larval Fat Body    52.4 Larval Salivary Gland    108.1 Larval Trachea    86.425 Larval Carcass    74.85 Adult Head    99.6 Adult Eye    66.95 Adult Brain    222.9 Adult Thoracic-Abdominal Ganglion    143 Adult Crop    55.3 Adult Midgut    76.7 Adult Hindgut    63.2 Adult Malpighian Tubules    49.2 Adult Fat Body    83.9 Adult Salivary Gland    108.8 Adult Heart    40.775 Adult VirginFemale Spermatheca    66.3 Adult InseminatedFemale Spermatheca    76.5 Adult Ovary    69.6 Adult Testis    19.7 Adult Male Accessory Gland    206.6 Adult Carcass    74.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    256.1 Larval Midgut    63.3 Larval Hindgut    62.7 Larval Malpighian Tubules    52.3 Larval Fat Body    52.4 Larval Salivary Gland    108.1 Larval Trachea    86.425 Larval Carcass    74.85 Adult Head    99.6 Adult Eye    66.95 Adult Brain    222.9 Adult Thoracic-Abdominal Ganglion    143 Adult Crop    55.3 Adult Midgut    76.7 Adult Hindgut    63.2 Adult Malpighian Tubules    49.2 Adult Fat Body    83.9 Adult Salivary Gland    108.8 Adult Heart    40.775 Adult VirginFemale Spermatheca    66.3 Adult InseminatedFemale Spermatheca    76.5 Adult Ovary    69.6 Adult Testis    19.7 Adult Male Accessory Gland    206.6 Adult Carcass    74.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    99.6   NA  Eye    66.95   NA  Brain    222.9   256.1  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    143   NA  Crop    55.3   63.3  Midgut    76.7   62.7  Hindgut    63.2   52.3  Malpighian Tubules    49.2   52.4  Fat Body    83.9   108.1  Salivary Gland    108.8   NA  Heart    40.775   86.425  Trachea    NA   NA  VirginFemale Spermatheca    66.3   NA  InseminatedFemale Spermatheca    76.5   NA  Ovary    69.6   NA  Testis    19.7   NA  Male Accessory Gland    206.6   74.85  Carcass    74.4 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    80 central nervous system, larvae L3    158 central nervous system, pupae P8    26 head, virgin 1-day female    14 head, virgin 4-day female    14 head, virgin 20-day female    17 head, mated 1-day female    15 head, mated 4-day female    17 head, mated 20-day female    19 head, mated 1-day male    16 head, mated 4-day male    24 head, mated 20-day male    25 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    15 digestive system, 4-day adult    21 digestive system, 20-day adult    16 fat body, larvae L3 wandering    8 fat body, white prepupae    27 fat body, pupae P8    24 carcass, larvae L3 wandering    68 carcass, 1-day adult    12 carcass, 4-day adult    20 carcass, 20-day adult    19 ovary, virgin 4-day female    149 ovary, mated 4-day female    105 testis, mated 4-day male    8 accessory gland, mated 4-day male    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (80) central nervous system, larvae L3  (158) central nervous system, pupae P8  26 head, virgin 1-day female    14 head, virgin 4-day female    14 head, virgin 20-day female    17 head, mated 1-day female    15 head, mated 4-day female    17 head, mated 20-day female    19 head, mated 1-day male    16 head, mated 4-day male    24 head, mated 20-day male    25 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    15 digestive system, 4-day adult    21 digestive system, 20-day adult    16 fat body, larvae L3 wandering    8 fat body, white prepupae  (27) fat body, pupae P8    24 carcass, larvae L3 wandering  (68) carcass, 1-day adult    12 carcass, 4-day adult    20 carcass, 20-day adult    19 ovary, virgin 4-day female  (149) ovary, mated 4-day female  (105) testis, mated 4-day male    8 accessory gland, mated 4-day male    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    80 central nervous system, larvae L3  (158) central nervous system, pupae P8    26 head, virgin 1-day female    14 head, virgin 4-day female    14 head, virgin 20-day female    17 head, mated 1-day female    15 head, mated 4-day female    17 head, mated 20-day female    19 head, mated 1-day male    16 head, mated 4-day male    24 head, mated 20-day male    25 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    15 digestive system, 4-day adult    21 digestive system, 20-day adult    16 fat body, larvae L3 wandering    8 fat body, white prepupae    27 fat body, pupae P8    24 carcass, larvae L3 wandering    68 carcass, 1-day adult    12 carcass, 4-day adult    20 carcass, 20-day adult    19 ovary, virgin 4-day female  (149) ovary, mated 4-day female  105 testis, mated 4-day male    8 accessory gland, mated 4-day male    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    80 central nervous system, larvae L3    158 central nervous system, pupae P8    26 head, virgin 1-day female    14 head, virgin 4-day female    14 head, virgin 20-day female    17 head, mated 1-day female    15 head, mated 4-day female    17 head, mated 20-day female    19 head, mated 1-day male    16 head, mated 4-day male    24 head, mated 20-day male    25 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    15 digestive system, 4-day adult    21 digestive system, 20-day adult    16 fat body, larvae L3 wandering    8 fat body, white prepupae    27 fat body, pupae P8    24 carcass, larvae L3 wandering    68 carcass, 1-day adult    12 carcass, 4-day adult    20 carcass, 20-day adult    19 ovary, virgin 4-day female    149 ovary, mated 4-day female    105 testis, mated 4-day male    8 accessory gland, mated 4-day male    18 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    80 central nervous system, larvae L3    158 central nervous system, pupae P8    26 head, virgin 1-day female    14 head, virgin 4-day female    14 head, virgin 20-day female    17 head, mated 1-day female    15 head, mated 4-day female    17 head, mated 20-day female    19 head, mated 1-day male    16 head, mated 4-day male    24 head, mated 20-day male    25 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    15 digestive system, 4-day adult    21 digestive system, 20-day adult    16 fat body, larvae L3 wandering    8 fat body, white prepupae    27 fat body, pupae P8    24 carcass, larvae L3 wandering    68 carcass, 1-day adult    12 carcass, 4-day adult    20 carcass, 20-day adult    19 ovary, virgin 4-day female    149 ovary, mated 4-day female    105 testis, mated 4-day male    8 accessory gland, mated 4-day male    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (80) central nervous system, larvae L3  (158) central nervous system, pupae P8  26 head, virgin 1-day female    14 head, virgin 4-day female    14 head, virgin 20-day female    17 head, mated 1-day female    15 head, mated 4-day female    17 head, mated 20-day female    19 head, mated 1-day male    16 head, mated 4-day male    24 head, mated 20-day male    25 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    15 digestive system, 4-day adult    21 digestive system, 20-day adult    16 fat body, larvae L3 wandering    8 fat body, white prepupae  27 fat body, pupae P8    24 carcass, larvae L3 wandering  (68) carcass, 1-day adult    12 carcass, 4-day adult    20 carcass, 20-day adult    19 ovary, virgin 4-day female  (149) ovary, mated 4-day female  (105) testis, mated 4-day male    8 accessory gland, mated 4-day male    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    80 central nervous system, larvae L3  (158) central nervous system, pupae P8    26 head, virgin 1-day female    14 head, virgin 4-day female    14 head, virgin 20-day female    17 head, mated 1-day female    15 head, mated 4-day female    17 head, mated 20-day female    19 head, mated 1-day male    16 head, mated 4-day male    24 head, mated 20-day male    25 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    15 digestive system, 4-day adult    21 digestive system, 20-day adult    16 fat body, larvae L3 wandering    8 fat body, white prepupae    27 fat body, pupae P8    24 carcass, larvae L3 wandering    68 carcass, 1-day adult    12 carcass, 4-day adult    20 carcass, 20-day adult    19 ovary, virgin 4-day female  (149) ovary, mated 4-day female  105 testis, mated 4-day male    8 accessory gland, mated 4-day male    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    80 central nervous system, larvae L3    158 central nervous system, pupae P8    26 head, virgin 1-day female    14 head, virgin 4-day female    14 head, virgin 20-day female    17 head, mated 1-day female    15 head, mated 4-day female    17 head, mated 20-day female    19 head, mated 1-day male    16 head, mated 4-day male    24 head, mated 20-day male    25 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    15 digestive system, 4-day adult    21 digestive system, 20-day adult    16 fat body, larvae L3 wandering    8 fat body, white prepupae    27 fat body, pupae P8    24 carcass, larvae L3 wandering    68 carcass, 1-day adult    12 carcass, 4-day adult    20 carcass, 20-day adult    19 ovary, virgin 4-day female    149 ovary, mated 4-day female    105 testis, mated 4-day male    8 accessory gland, mated 4-day male    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    115 embryo 02-04hr    185 embryo 04-06hr    204 embryo 06-08hr    253 embryo 08-10hr    183 embryo 10-12hr    110 embryo 12-14hr    84 embryo 14-16hr    66 embryo 16-18hr    47 embryo 18-20hr    33 embryo 20-22hr    49 embryo 22-24hr    43 larva L1    33 larva L2    27 larva L3 12hr old    21 larva L3 puffstage 1-2    20 larva L3 puffstage 3-6    38 larva L3 puffstage 7-9    39 white prepupae new    42 white prepupae 12hr    40 white prepupae 24hr    49 pupae 2d postWPP    17 pupae 3d postWPP    7 pupae 4d postWPP    9 adult male 01day    10 adult male 05day    11 adult male 30day    11 adult female 01day    41 adult female 05day    63 adult female 30day    64 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (115) embryo 02-04hr  (185) embryo 04-06hr  (204) embryo 06-08hr  (253) embryo 08-10hr  (183) embryo 10-12hr  (110) embryo 12-14hr  (84) embryo 14-16hr  (66) embryo 16-18hr  (47) embryo 18-20hr  (33) embryo 20-22hr  (49) embryo 22-24hr  (43) larva L1  (33) larva L2  (27) larva L3 12hr old    21 larva L3 puffstage 1-2    20 larva L3 puffstage 3-6  (38) larva L3 puffstage 7-9  (39) white prepupae new  (42) white prepupae 12hr  (40) white prepupae 24hr  (49) pupae 2d postWPP    17 pupae 3d postWPP    7 pupae 4d postWPP    9 adult male 01day    10 adult male 05day    11 adult male 30day    11 adult female 01day  (41) adult female 05day  (63) adult female 30day  (64) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (115) embryo 02-04hr  (185) embryo 04-06hr  (204) embryo 06-08hr  (253) embryo 08-10hr  (183) embryo 10-12hr  (110) embryo 12-14hr    84 embryo 14-16hr    66 embryo 16-18hr    47 embryo 18-20hr    33 embryo 20-22hr    49 embryo 22-24hr    43 larva L1    33 larva L2    27 larva L3 12hr old    21 larva L3 puffstage 1-2    20 larva L3 puffstage 3-6    38 larva L3 puffstage 7-9    39 white prepupae new    42 white prepupae 12hr    40 white prepupae 24hr    49 pupae 2d postWPP    17 pupae 3d postWPP    7 pupae 4d postWPP    9 adult male 01day    10 adult male 05day    11 adult male 30day    11 adult female 01day    41 adult female 05day    63 adult female 30day    64 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    115 embryo 02-04hr    185 embryo 04-06hr    204 embryo 06-08hr    253 embryo 08-10hr    183 embryo 10-12hr    110 embryo 12-14hr    84 embryo 14-16hr    66 embryo 16-18hr    47 embryo 18-20hr    33 embryo 20-22hr    49 embryo 22-24hr    43 larva L1    33 larva L2    27 larva L3 12hr old    21 larva L3 puffstage 1-2    20 larva L3 puffstage 3-6    38 larva L3 puffstage 7-9    39 white prepupae new    42 white prepupae 12hr    40 white prepupae 24hr    49 pupae 2d postWPP    17 pupae 3d postWPP    7 pupae 4d postWPP    9 adult male 01day    10 adult male 05day    11 adult male 30day    11 adult female 01day    41 adult female 05day    63 adult female 30day    64 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    115 embryo 02-04hr    185 embryo 04-06hr    204 embryo 06-08hr    253 embryo 08-10hr    183 embryo 10-12hr    110 embryo 12-14hr    84 embryo 14-16hr    66 embryo 16-18hr    47 embryo 18-20hr    33 embryo 20-22hr    49 embryo 22-24hr    43 larva L1    33 larva L2    27 larva L3 12hr old    21 larva L3 puffstage 1-2    20 larva L3 puffstage 3-6    38 larva L3 puffstage 7-9    39 white prepupae new    42 white prepupae 12hr    40 white prepupae 24hr    49 pupae 2d postWPP    17 pupae 3d postWPP    7 pupae 4d postWPP    9 adult male 01day    10 adult male 05day    11 adult male 30day    11 adult female 01day    41 adult female 05day    63 adult female 30day    64 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (115) embryo 02-04hr  (185) embryo 04-06hr  (204) embryo 06-08hr  (253) embryo 08-10hr  (183) embryo 10-12hr  (110) embryo 12-14hr  (84) embryo 14-16hr  (66) embryo 16-18hr  (47) embryo 18-20hr  (33) embryo 20-22hr  (49) embryo 22-24hr  (43) larva L1  (33) larva L2  27 larva L3 12hr old    21 larva L3 puffstage 1-2    20 larva L3 puffstage 3-6  (38) larva L3 puffstage 7-9  (39) white prepupae new  (42) white prepupae 12hr  (40) white prepupae 24hr  (49) pupae 2d postWPP    17 pupae 3d postWPP    7 pupae 4d postWPP    9 adult male 01day    10 adult male 05day    11 adult male 30day    11 adult female 01day  (41) adult female 05day  (63) adult female 30day  (64) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  115 embryo 02-04hr  (185) embryo 04-06hr  (204) embryo 06-08hr  (253) embryo 08-10hr  (183) embryo 10-12hr  110 embryo 12-14hr    84 embryo 14-16hr    66 embryo 16-18hr    47 embryo 18-20hr    33 embryo 20-22hr    49 embryo 22-24hr    43 larva L1    33 larva L2    27 larva L3 12hr old    21 larva L3 puffstage 1-2    20 larva L3 puffstage 3-6    38 larva L3 puffstage 7-9    39 white prepupae new    42 white prepupae 12hr    40 white prepupae 24hr    49 pupae 2d postWPP    17 pupae 3d postWPP    7 pupae 4d postWPP    9 adult male 01day    10 adult male 05day    11 adult male 30day    11 adult female 01day    41 adult female 05day    63 adult female 30day    64 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    115 embryo 02-04hr    185 embryo 04-06hr    204 embryo 06-08hr    253 embryo 08-10hr    183 embryo 10-12hr    110 embryo 12-14hr    84 embryo 14-16hr    66 embryo 16-18hr    47 embryo 18-20hr    33 embryo 20-22hr    49 embryo 22-24hr    43 larva L1    33 larva L2    27 larva L3 12hr old    21 larva L3 puffstage 1-2    20 larva L3 puffstage 3-6    38 larva L3 puffstage 7-9    39 white prepupae new    42 white prepupae 12hr    40 white prepupae 24hr    49 pupae 2d postWPP    17 pupae 3d postWPP    7 pupae 4d postWPP    9 adult male 01day    10 adult male 05day    11 adult male 30day    11 adult female 01day    41 adult female 05day    63 adult female 30day    64 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    68 Schneider line 2 Sg4    61 embryonic 1182-4H    67 embryonic GM2    65 embryonic Kc167    23 embryonic S1    97 embryonic S3    78 leg disc CME L1    91 wing disc CME-W2    44 wing disc ML-DmD8    35 wing disc ML-DmD9    88 wing disc ML-DmD16-c3    107 wing disc ML-DmD21    73 wing disc ML-DmD32    56 haltere disc ML-DmD17-c3    72 eye-antennal disc ML-DmD11    68 antennal disc ML-DmD20-c5    48 mixed discs ML-DmD4-c1    103 CNS ML-DmBG1-c1    73 CNS ML-DmBG2-c2    69 tumorous blood cells mbn2    40 ovary fGS/OSS    105 ovary OSC    108 ovary OSS    69 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (68) Schneider line 2 Sg4  (61) embryonic 1182-4H  (67) embryonic GM2  (65) embryonic Kc167    23 embryonic S1  (97) embryonic S3  (78) leg disc CME L1  (91) wing disc CME-W2  (44) wing disc ML-DmD8  (35) wing disc ML-DmD9  (88) wing disc ML-DmD16-c3  (107) wing disc ML-DmD21  (73) wing disc ML-DmD32  (56) haltere disc ML-DmD17-c3  (72) eye-antennal disc ML-DmD11  (68) antennal disc ML-DmD20-c5  (48) mixed discs ML-DmD4-c1  (103) CNS ML-DmBG1-c1  (73) CNS ML-DmBG2-c2  (69) tumorous blood cells mbn2  (40) ovary fGS/OSS  (105) ovary OSC  (108) ovary OSS  (69) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    68 Schneider line 2 Sg4    61 embryonic 1182-4H    67 embryonic GM2    65 embryonic Kc167    23 embryonic S1    97 embryonic S3    78 leg disc CME L1    91 wing disc CME-W2    44 wing disc ML-DmD8    35 wing disc ML-DmD9    88 wing disc ML-DmD16-c3  107 wing disc ML-DmD21    73 wing disc ML-DmD32    56 haltere disc ML-DmD17-c3    72 eye-antennal disc ML-DmD11    68 antennal disc ML-DmD20-c5    48 mixed discs ML-DmD4-c1  103 CNS ML-DmBG1-c1    73 CNS ML-DmBG2-c2    69 tumorous blood cells mbn2    40 ovary fGS/OSS  105 ovary OSC  (108) ovary OSS    69 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    68 Schneider line 2 Sg4    61 embryonic 1182-4H    67 embryonic GM2    65 embryonic Kc167    23 embryonic S1    97 embryonic S3    78 leg disc CME L1    91 wing disc CME-W2    44 wing disc ML-DmD8    35 wing disc ML-DmD9    88 wing disc ML-DmD16-c3    107 wing disc ML-DmD21    73 wing disc ML-DmD32    56 haltere disc ML-DmD17-c3    72 eye-antennal disc ML-DmD11    68 antennal disc ML-DmD20-c5    48 mixed discs ML-DmD4-c1    103 CNS ML-DmBG1-c1    73 CNS ML-DmBG2-c2    69 tumorous blood cells mbn2    40 ovary fGS/OSS    105 ovary OSC    108 ovary OSS    69 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    68 Schneider line 2 Sg4    61 embryonic 1182-4H    67 embryonic GM2    65 embryonic Kc167    23 embryonic S1    97 embryonic S3    78 leg disc CME L1    91 wing disc CME-W2    44 wing disc ML-DmD8    35 wing disc ML-DmD9    88 wing disc ML-DmD16-c3    107 wing disc ML-DmD21    73 wing disc ML-DmD32    56 haltere disc ML-DmD17-c3    72 eye-antennal disc ML-DmD11    68 antennal disc ML-DmD20-c5    48 mixed discs ML-DmD4-c1    103 CNS ML-DmBG1-c1    73 CNS ML-DmBG2-c2    69 tumorous blood cells mbn2    40 ovary fGS/OSS    105 ovary OSC    108 ovary OSS    69 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (68) Schneider line 2 Sg4  (61) embryonic 1182-4H  (67) embryonic GM2  (65) embryonic Kc167    23 embryonic S1  (97) embryonic S3  (78) leg disc CME L1  (91) wing disc CME-W2  (44) wing disc ML-DmD8  (35) wing disc ML-DmD9  (88) wing disc ML-DmD16-c3  (107) wing disc ML-DmD21  (73) wing disc ML-DmD32  (56) haltere disc ML-DmD17-c3  (72) eye-antennal disc ML-DmD11  (68) antennal disc ML-DmD20-c5  (48) mixed discs ML-DmD4-c1  (103) CNS ML-DmBG1-c1  (73) CNS ML-DmBG2-c2  (69) tumorous blood cells mbn2  (40) ovary fGS/OSS  (105) ovary OSC  (108) ovary OSS  (69) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    68 Schneider line 2 Sg4    61 embryonic 1182-4H    67 embryonic GM2    65 embryonic Kc167    23 embryonic S1    97 embryonic S3    78 leg disc CME L1    91 wing disc CME-W2    44 wing disc ML-DmD8    35 wing disc ML-DmD9    88 wing disc ML-DmD16-c3  107 wing disc ML-DmD21    73 wing disc ML-DmD32    56 haltere disc ML-DmD17-c3    72 eye-antennal disc ML-DmD11    68 antennal disc ML-DmD20-c5    48 mixed discs ML-DmD4-c1  103 CNS ML-DmBG1-c1    73 CNS ML-DmBG2-c2    69 tumorous blood cells mbn2    40 ovary fGS/OSS  105 ovary OSC  108 ovary OSS    69 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    68 Schneider line 2 Sg4    61 embryonic 1182-4H    67 embryonic GM2    65 embryonic Kc167    23 embryonic S1    97 embryonic S3    78 leg disc CME L1    91 wing disc CME-W2    44 wing disc ML-DmD8    35 wing disc ML-DmD9    88 wing disc ML-DmD16-c3    107 wing disc ML-DmD21    73 wing disc ML-DmD32    56 haltere disc ML-DmD17-c3    72 eye-antennal disc ML-DmD11    68 antennal disc ML-DmD20-c5    48 mixed discs ML-DmD4-c1    103 CNS ML-DmBG1-c1    73 CNS ML-DmBG2-c2    69 tumorous blood cells mbn2    40 ovary fGS/OSS    105 ovary OSC    108 ovary OSS    69 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    21 heat shock, 4-day adult    28 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    34 Cadmium 100 mM 48 hrs, 4-day adult    74 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    84 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    63 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    68 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    54 Paraquat 10 mM 48 hrs, 4-day adult    44 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  26 cold shock, 4-day adult    21 heat shock, 4-day adult  (28) Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult  (34) Cadmium 100 mM 48 hrs, 4-day adult  (74) Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult  (84) Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult  (31) Ethanol 2.5% 3 hrs, larvae L3  (63) Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (68) Caffeine 25 mg/ml 48 hrs, 4-day adult  (33) Paraquat 5 mM 48 hrs, 4-day adult  (54) Paraquat 10 mM 48 hrs, 4-day adult  (44) Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    21 heat shock, 4-day adult    28 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    34 Cadmium 100 mM 48 hrs, 4-day adult    74 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    84 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    63 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    68 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    54 Paraquat 10 mM 48 hrs, 4-day adult    44 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    21 heat shock, 4-day adult    28 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    34 Cadmium 100 mM 48 hrs, 4-day adult    74 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    84 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    63 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    68 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    54 Paraquat 10 mM 48 hrs, 4-day adult    44 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    21 heat shock, 4-day adult    28 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    34 Cadmium 100 mM 48 hrs, 4-day adult    74 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    84 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    63 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    68 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    54 Paraquat 10 mM 48 hrs, 4-day adult    44 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  26 cold shock, 4-day adult    21 heat shock, 4-day adult  28 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult  (34) Cadmium 100 mM 48 hrs, 4-day adult  (74) Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult  (84) Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult  31 Ethanol 2.5% 3 hrs, larvae L3  (63) Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (68) Caffeine 25 mg/ml 48 hrs, 4-day adult  (33) Paraquat 5 mM 48 hrs, 4-day adult  (54) Paraquat 10 mM 48 hrs, 4-day adult  (44) Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    21 heat shock, 4-day adult    28 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    34 Cadmium 100 mM 48 hrs, 4-day adult    74 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    84 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    63 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    68 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    54 Paraquat 10 mM 48 hrs, 4-day adult    44 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    21 heat shock, 4-day adult    28 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    34 Cadmium 100 mM 48 hrs, 4-day adult    74 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    84 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    63 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    68 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    54 Paraquat 10 mM 48 hrs, 4-day adult    44 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • LD15904 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259785
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal pzgGD9955 lethal, with Scer\GAL4T80 pzgScer\UAS.cEa lethal (with Df(3L)Pc-2q) pzg66 lethal (with Df(3L)Pc) pzg66 lethal (with Df(3L)Pc-MK) pzg66 lethal | embryonic stage | recessive pzg1.3 lethal | heat sensitive, with Scer\GAL4da.G32 pzgdsRNA.Scer\UAS lethal | larval stage | recessive pzg66 lethal | pupal stage | recessive pzg7.1 partially lethal - majority die pzgCB02305 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 pzgGD9955 Other Phenotypes Allele developmental rate defective, with Scer\GAL4da.G32 pzgdsRNA.Scer\UAS developmental rate defective | larval stage pzg66 enhancer of variegation, with In(1)wm4 pzgT:Hsap\MYC locomotor behavior defective | larval stage pzg66 melanotic mass phenotype | adult stage, with Scer\GAL4Cg.PA pzgdsRNA.Scer\UAS melanotic mass phenotype | adult stage, with Scer\GAL4Hml.PG pzgdsRNA.Scer\UAS melanotic mass phenotype | larval stage, with Scer\GAL4Cg.PA pzgdsRNA.Scer\UAS melanotic mass phenotype | larval stage, with Scer\GAL4Hml.PG pzgdsRNA.Scer\UAS melanotic mass phenotype | pupal stage, with Scer\GAL4Cg.PA pzgdsRNA.Scer\UAS melanotic mass phenotype | pupal stage, with Scer\GAL4Hml.PG pzgdsRNA.Scer\UAS neuroanatomy defective | larval stage pzgGD9955 small body | larval stage pzg66 suppressor of variegation | dominant, with In(1)wm4 pzg1.3 pzg7.1 visible, with Scer\GAL4en-e16E pzgdsRNA.Scer\UAS visible, with Scer\GAL4ey.PH pzgdsRNA.Scer\UAS pzgScer\UAS.cEa visible, with Scer\GAL4pnr-MD237 pzgGD9955 visible, with Scer\GAL4sd-SG29.1 pzgdsRNA.Scer\UAS Phenotype manifest in Allele embryonic/larval neuroblast | larval stage pzgGD9955 embryonic/larval salivary gland, with Scer\GAL4G61 pzgScer\UAS.cEa eye, with Scer\GAL4ey.PH pzgScer\UAS.cEa pzgdsRNA.Scer\UAS ganglion mother cell | larval stage pzgGD9955 melanotic mass | adult stage, with Scer\GAL4Cg.PA pzgdsRNA.Scer\UAS melanotic mass | adult stage, with Scer\GAL4Hml.PG pzgdsRNA.Scer\UAS melanotic mass | larval stage, with Scer\GAL4Cg.PA pzgdsRNA.Scer\UAS melanotic mass | larval stage, with Scer\GAL4Hml.PG pzgdsRNA.Scer\UAS melanotic mass | pupal stage, with Scer\GAL4Cg.PA pzgdsRNA.Scer\UAS melanotic mass | pupal stage, with Scer\GAL4Hml.PG pzgdsRNA.Scer\UAS mesothoracic tergum, with Scer\GAL4pnr-MD237 pzgGD9955 polytene chromosome pzg7.1 polytene chromosome (with pzg1.3) pzg7.1 polytene chromosome (with pzg7.1) pzg1.3 polytene chromosome band pzg7.1 polytene chromosome band (with pzg1.3) pzg7.1 polytene chromosome band (with pzg7.1) pzg1.3 wing, with Scer\GAL4en-e16E pzgdsRNA.Scer\UAS wing, with Scer\GAL4sd-SG29.1 pzgdsRNA.Scer\UAS
Classical Alleles ( 11 )
For All Classical Alleles Show
Allele of pzg Class Mutagen Stocks Known lesion pzgc00261 piggyBac transposase 1 -- pzgc06011 piggyBac transposase 1 -- pzgEY11005 P-element activity 1 -- pzg66 amorphic allele - molecular evidence Delta2-3 0 Yes pzg1.3 Delta2-3 0 Yes pzg5-HA-2964 0 -- pzg7.1 Delta2-3 0 Yes pzgc02767 piggyBac transposase 0 -- pzgCB02305 P-element activity 0 Yes pzgEP756 0 Yes pzgGS-A1165 Delta2-3 0 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of pzg Class Mutagen Stocks Known lesion pzgGD9955 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes pzgGL00373 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes pzgdsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes pzgNIG.7752R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes pzgScer\UAS.cEa in vitro construct - regulatory fusion 0 Yes pzgScer\UAS.cKa in vitro construct - regulatory fusion 0 Yes pzgT:Hsap\MYC in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Pc (Kugler et al., 2011) Df(3L)Pc-2q (Kugler et al., 2011) Df(3L)Pc-MK (Kugler et al., 2011)
Partially disrupted in	Df(3L)Z4-1.3 (Eggert et al., 2004)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{NIG.7752R} NA P{TRiP.GL00373} NA P{UAS-pzg.K} NA P{UAS-pzg.RNAi} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}CG12974EP756 NA P{EPgy2}pzgEY11005 NA P{GSV1}pzgGS-A1165 NA miscellaneous insertions P{3'SUPor-P}pzg66 NA P{PTT-GB}pzgCB02305 NA P{RS5}pzg5-HA-2964 NA P{SUPor-P}KG04911 NA PBac{PB}pzgc00261 NA PBac{PB}pzgc02767 NA PBac{PB}pzgc06011 NA
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 10 terms )
Molecular Function
CV term Evidence References
chromatin binding inferred from direct assay (Kugler and Nagel, 2010)
Biological Process
CV term Evidence References
cell cycle inferred from mutant phenotype (Nagel et al., 2005) chromosome organization inferred from mutant phenotype (Eggert et al., 2004) ecdysone receptor-mediated signaling pathway inferred from mutant phenotype (Kugler et al., 2011) negative regulation of JAK-STAT cascade inferred from mutant phenotype (Kugler et al., 2011) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) positive regulation of Notch signaling pathway inferred from genetic interaction with N (Kugler and Nagel, 2010)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Kugler and Nagel, 2007, Eggert et al., 2004) NURF complex inferred from physical interaction with E(bx), Iswi, Caf1, Nurf-38 (Kugler and Nagel, 2010) polytene chromosome interband inferred from direct assay (Eggert et al., 2004, Gortchakov et al., 2005)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
DNA binding non-traceable author statement (Eggert et al., 2003) zinc ion binding inferred from electronic annotation with InterPro:IPR007087, InterPro:IPR015880 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
chromatin organization non-traceable author statement (Eggert et al., 2003)
Cellular Component
CV term Evidence References
polytene chromosome interband non-traceable author statement (Eggert et al., 2003)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
pzg - Aats-asn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pzg - BEAF-32 anti bait coimmunoprecipitation, western blot (Gan et al., 2011) pzg - CG10321 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pzg - CG10681 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pzg - CG12236 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pzg - CG15514 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pzg - CG1603 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pzg - CG1792 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pzg - CG3542 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pzg - CG3995 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pzg - CG4854 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pzg - CG6689 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pzg - CG8745 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pzg - CG9797 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pzg - CanA1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pzg - Chro experimental knowledge based, two hybrid (Guruharsha et al., 2011, Gan et al., 2011) pzg - Dredd anti tag coimmunoprecipitation, peptide massfingerprinting (Fukuyama et al., 2012) pzg - JIL-1 anti bait coimmunoprecipitation, western blot (Gan et al., 2011) pzg - Kr-h1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pzg - Mkk4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pzg - Opbp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pzg - RagC-D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pzg - RpLP0 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pzg - S-Lap1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pzg - SmD3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pzg - Trl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pzg - Zif anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pzg - brk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pzg - grau anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pzg - gus anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pzg - ken anti bait coimmunoprecipitation, western blot (Kugler et al., 2011) pzg - lack anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pzg - row experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) pzg - sax anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pzg - slbo anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pzg - ttk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pzg - wee anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) pzg - wek anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions pzg allele Gene References unspecified ct (Krupp et al., 2005) CycE (Kugler and Nagel, 2007) dap (Kugler and Nagel, 2007) grim (Mueller et al., 2005) H (Kugler and Nagel, 2007, Mueller et al., 2005) mus209 (Kugler and Nagel, 2007) N (Kugler and Nagel, 2007) rpr (Mueller et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65599 DroID - A comprehensive database of gene and protein interactions. • FBgn0259785 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40351
Orthologs
OrthoDB Orthologs (72) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG68SHCG Dipteran inclusive ortholog search EOG698V7V Insect inclusive ortholog search EOG6PC8MX Arthropod inclusive ortholog search EOG6K98SZ Metazoa inclusive ortholog search EOG6CP3HQ
Orthologs in Drosophila Species (EOG68SHCG)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Ubx     Drosophila melanogaster fruit fly  Dmel\mask     Drosophila melanogaster fruit fly  Dmel\pzg     Drosophila simulans   Dsim\GD21080   Y Drosophila sechellia   Dsec\GM26576   Y Drosophila erecta   Dere\GG11270   Y Drosophila erecta   Dere\GG13905   Y Drosophila erecta   Dere\GG16353   Y Drosophila erecta   Dere\GG13621   Y Drosophila yakuba   Dyak\GE12807   Y Drosophila yakuba   Dyak\GE21759   Y Drosophila yakuba   Dyak\GE23462   Y Drosophila yakuba   Dyak\GE24879   Y Drosophila yakuba   Dyak\GE16132   Y Drosophila ananassae   Dana\GF24304 Y Y Drosophila ananassae   Dana\GF15139   Y Drosophila ananassae   Dana\GF16118   Y Drosophila ananassae   Dana\GF23262   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA27251   Y Drosophila persimilis   Dper\GL19632   Y Drosophila persimilis   Dper\GL23419   Y Drosophila willistoni   Dwil\GK11389   Y Drosophila virilis   Dvir\GJ10528   Y Drosophila mojavensis   Dmoj\GI12555   Y Drosophila mojavensis   Dmoj\GI15390   Y Drosophila mojavensis   Dmoj\GI17826   Y Drosophila mojavensis   Dmoj\GI23579   Y Drosophila mojavensis   Dmoj\GI11788   Y Drosophila mojavensis   Dmoj\GI24181   Y Drosophila grimshawi   Dgri\GH18670   Y Drosophila grimshawi   Dgri\GH10927   Y
Orthologs in non-Drosophila Dipterans (EOG698V7V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL004651 Y Anopheles gambiae Malaria mosquito  Agam\AGAP010846 Y Anopheles gambiae Malaria mosquito  Agam\AGAP003519 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002710 Y
Orthologs in non-Dipteran Insects (EOG6PC8MX)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB52985 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG016792 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG016781 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15907 Y Atta cephalotes Leafcutter ant  Acep\ACEP10961 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO14755 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22369 Y Linepithema humile Argentine ant  Lhum\LH26053 Y Linepithema humile Argentine ant  Lhum\LH23585 Y Linepithema humile Argentine ant  Lhum\LH23583 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB24046 Y Solenopsis invicta Red fire ant  Sinv\SINV14899 Y Solenopsis invicta Red fire ant  Sinv\SINV15068 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI008142 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI007888 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI086044 Y Bombyx mori Silkmoth  Bmor\BGIBMGA006327 Y Bombyx mori Silkmoth  Bmor\BGIBMGA006328 Y Pediculus humanus Human body louse  Phum\PHUM473040 Y Tribolium castaneum Red flour beetle  Tcas\TC001033 Y
Orthologs in non-Insect Arthropods (EOG6K98SZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Ixodes scapularis Deer tick  Isca\ISCW008360 Y
Orthologs in non-Arthropod Metazoa (EOG6CP3HQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\R11A8.7 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_021764gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_019054gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_022642gn Y Danio rerio Zebrafish  Drer\ankhd1 Y Xenopus tropicalis Western clawed frog  Xtro\ankhd1 Y Xenopus tropicalis Western clawed frog  Xtro\ankrd17 Y Gallus gallus Domestic chicken  Ggal\ANKRD17 Y Gallus gallus Domestic chicken  Ggal\ANKHD1 Y Mus musculus House mouse  Mmus\Ankhd1 Y Mus musculus House mouse  Mmus\Ankrd17 Y Rattus norvegicus Norway rat  Rnor\Ankrd17 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000030247 Y Homo sapiens Human  Hsap\ANKHD1 Y Homo sapiens Human  Hsap\ANKHD1-EIF4EBP3 Y Homo sapiens Human  Hsap\ANKRD17 Y
Human Orthologs (3)
Gene OMIM HGNC Hsap\ANKHD1     Hsap\ANKHD1-EIF4EBP3     Hsap\ANKRD17
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD14946 Drosophila sechellia Dsec\GM22352 Drosophila erecta Dere\GG16169 Drosophila yakuba Dyak\GE23052 Drosophila ananassae Dana\GF24304 Drosophila pseudoobscura pseudoobscura Dpse\GA20561 Drosophila persimilis Dper\GL24674 Drosophila willistoni Dwil\GK20464 Drosophila virilis Dvir\GJ13882 Drosophila mojavensis Dmoj\GI13135 Drosophila grimshawi Dgri\GH14973
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	35448 y1 sc* v1; P{TRiP.GL00373}attP2 20653 y1 w67c23; P{EPgy2}pzgEY11005/TM3, Sb1 Ser1
Harvard	- PBac{PB}pzgc00261 - PBac{PB}pzgc06011
VDRC	v25541 w1118; P{GD9955}v25541 v25542 w1118; P{GD9955}v25542
Genomic Clones ( 1 )
	BACR02C22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 146 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD15904
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH01693 GH17236 GM01481 GM21931 GM22630 LD02121 LD02283 LD02309 LD02763 LD02901 LD03245 LD03360 LD05584 LD05682 LD07815 LD09477 LD09516 LD11305 LD12383 LD12460 LD13619 LD13862 LD17888 LD18189 LD21862 LD22006 LD22767 LD22819 LD26582 LD27133 LD27664 LD28308 LD28449 LD31135 LD31662 LD31979 LD32593 LD33148 LD33885 LD34546 LD36235 LD37290 LD37522 LD38406 LD40358 LD40370 LD40646 LD41194 LD43089 LD43601 LD44284 LD45602 LD46270 LD46320 LD47135 LP11995 LP21543 RE07047 RE08519 RE09479 RE11140 RE17731 RE19003 RE21115 RE22850 RE22909 RE28341 RE28355 RE31084 RE32238 RE33553 RE35634 RE42777 RE49370 RE50264 RE50479 RE51270 RE53836 RE53860 RE55424 RE60641 RE64489 RE69429 RE69491 RE71358 RE72443 RE74079 RE74935 RE75092 SD03052 SD04327 SD04688 SD05211 SD05320 SD08260 SD08813 SD19283 SD20840 SD22081 SD22543 SD27265
Other clones	1699 7560 14553 28255 30195 37087 50444 52921 57543 63348 71956 77827 97579 101330 118537 181195 273804 281812 569011 CK01.33C.B10 CK01.130D.F6 CK01.168B.C12 Dmel_neb_008071_0589_0543 Dmel_neb_009485_0647_2460 EK030229 EK100555 EK103144 EK123242 EK125424 EK138755 EK148145 EK168717 EK200240 EK211458 EK220027 EK237826 EK243546 EK306544 EN14346 EP09706 FGM224C11 LD13307 LD31327 UT01867
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0259785 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40351
Antibody Information
Other Information
Discoverer
Etymology
	Gene is named "putzig" (German for tiny/droll) owing to its influence on the growth of larvae. (Kugler and Nagel, 2007)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Z4 CG7752 (Eggert, 2004.11.5)
Source for database merge of	Source for merge of: pzg Z4 (Kugler and Nagel, 2007)
Additional comments
Other Comments
	Identification: as a suppressor of H mediated cell death induction. (Nagel et al., 2005) Reduction in levels of pzg gene activity during larval development results in developmental delays and reduction of tissue size due to impaired cell cycle progression and induction of cell death. (Nagel et al., 2005) Null mutants of Z4 are embryonic lethal and hypomorphic mutants die at late larval/early pupal stages. Z4 mutants have a dosage-sensitive effect on position-effect variegation with a haplo-suppressor and triplo-enhancer phenotype. (Eggert et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141040 NM_001275214 RefSeq (Proteins) • NP_649297 NP_001262143 DDBJ / EMBL / GenBank • AA440859 AAF51699 AAQ22526 AGB94836 AW942384 BT010057 CL868468 CZ466326 CZ468192 CZ470424 CZ470425 Entrez Gene - A searchable database of RefSeq genes. • 40351 UniProtKB/TrEMBL • Q9VP57
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2-like (IPR015880) Zinc finger, C2H2 (IPR007087) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD15904
Linkouts
	BioGRID - A database of protein and genetic interactions • 65599 DroID - A comprehensive database of gene and protein interactions. • FBgn0259785 DRSC - Results from RNAi screens. • FBgn0259785 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259785 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0259785 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40351 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/putzig.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40351 modMine - Data generated by the modENCODE project. • FBgn0259785
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	CG7752 (Kugler and Nagel, 2007, Mueller et al., 2005, Krupp et al., 2005, Brody et al., 2002, Stuart et al., 2007, Baeg et al., 2007, Eggert et al., 2004, Ni et al., 2011.7.19, Cammarato et al., 2011, Azad et al., 2012) p160 (Hochheimer et al., 2002, Hochheimer et al., 2002) pzg (Kugler and Nagel, 2007, Kugler and Nagel, 2007, Kugler et al., 2011, Takács et al., 2012, Azad et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Antao et al., 2012) Pzg (Kallappagoudar et al., 2010) Q9VP57_DROME (Fukuyama et al., 2012) Z4 (Prestel et al., 2010, Mendjan et al., 2006, Demakova et al., 2007, Gan et al., 2007, Buszczak et al., 2007, Eggert et al., 2004, Andreyeva et al., 2007, Gortchakov et al., 2005, Andreyeva et al., 2005, Raja et al., 2010, Semeshin et al., 2002, Wang et al., 2013, Gan et al., 2011) z4 (Larschan et al., 2012)
Name Synonym	putzig (Nagel et al., 2005, Kugler and Nagel, 2007, Kugler et al., 2011, Kugler and Nagel, 2010) Z4 (Cammarato et al., 2011)
Secondary FlyBase IDs
	FBgn0037066 FBgn0083067
References ( 57 )
Generate a list of	All references relating to this gene ( 57 )
List References by type	Research paper  ( 28 ) Supplementary material  ( 8 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 6 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 10 )
	Wang et al., 2013, Nat. Struct. Mol. Biol. 20(2): 202--209 Chromatin proteins captured by ChIP-mass spectrometry are linked to dosage compensation in Drosophila. [FBrf0220693] Antao et al., 2012, Mol. Cell. Biol. 32(12): 2170--2182 Protein Landscape at Drosophila melanogaster Telomere-Associated Sequence Repeats. [FBrf0218429] Azad et al., 2012, G3 (Bethesda) 2(10): 1169--1178 Identification of Genes Underlying Hypoxia Tolerance in Drosophila by a P-element Screen. [FBrf0219647] Fukuyama et al., 2012, J. Proteomics 75(15): 4610--4619 On-bead tryptic proteolysis: An attractive procedure for LC-MS/MS analysis of the Drosophila caspase 8 protein complex during immune response against bacteria. [FBrf0218992] Krauchunas et al., 2012, Dev. Biol. 370(1): 125--134 Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. [FBrf0219342] Larschan et al., 2012, PLoS Genet. 8(7): e1002830 Identification of Chromatin-Associated Regulators of MSL Complex Targeting in Drosophila Dosage Compensation. [FBrf0219020] Silva-Sousa et al., 2012, PLoS Genet. 8(12): e1003153 The Chromosomal Proteins JIL-1 and Z4/Putzig Regulate the Telomeric Chromatin in Drosophila melanogaster. [FBrf0220335] Takács et al., 2012, Int. J. Biol. Sci. 8(7): 1055--1061 Protein interactions on telomeric retrotransposons in Drosophila. [FBrf0219367] Gan et al., 2011, J. Biosci., Bangalore 36(3): 425--438 The Chriz-Z4 complex recruits JIL-1 to polytene chromosomes, a requirement for interband-specific phosphorylation of H3S10. [FBrf0216935] Kugler et al., 2011, Genetics 188(1): 127--139 The Putzig-NURF Nucleosome Remodeling Complex Is Required for Ecdysone Receptor Signaling and Innate Immunity in Drosophila melanogaster. [FBrf0213648] Show all research papers ...