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Gene Dmel\bora

General Information
Symbol	Dmel\bora	Species	D. melanogaster
Name	aurora borealis	Annotation symbol	CG6897
Feature type	protein_coding_gene	FlyBase ID	FBgn0259791
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	75D4-75D4	Sequence location	3L:18,615,794..18,617,855 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene aurora borealis is referred to in FlyBase by the symbol Dmel\bora (CG6897, FBgn0259791). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: asymmetric protein localization involved in cell fate determination; activation of protein kinase activity; peripheral nervous system development. 6 alleles are reported. The phenotype of these alleles is annotated with: tormogen cell. It has one annotated transcript and one annotated polypeptide. Protein features are: Aurora borealis protein. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1638411_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of bora. Gene sequence location is 3L:18615794..18617855.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features BKN45296 HFA10744 BKN25816
FB2011_10	References Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 75D4-75D4   Limits computationally determined from genome sequence between P{PZ}W05014 and P{lacW}l(3)j14E7j14E7
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\bora for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) bora-RA FBtr0075108  NM_140791   2004   539
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein bora-PA   FBpp0074874   59.1   539   6.51     NP_649048   AAF49248
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Aurora borealis protein (IPR023252)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202134   AA202993   AA246674   AA263602   AA390536   AA392012   AA392993   AA438709   AA440551   AA441477   AA538828   AA539998   AA540104   AA816269   AA817521   AA820438   AA938856   AA949088   AA949806   AA950330   AA952255   AA979138   AA979146   AE014296 AAF49248   AI061697   AI512771   AI513194   AI514333   AI520107   AI546384   AI546386   AW942779   AY070548 AAL48019   BF501659   BG637910   BG638390   BI213662   BI214695   BI216004   BI241672   BI356475   BI356701   BI366599   BI366813   BI370595   BI373596   BI579443   BI633052   CO177341   CO268795   CO284881   CO286470   CO292616   CO298534   CO298562   CO302988   CO303062   CO306668   CO316463   EC066413   EC069268   EC077004   EC087780   EC088498   EC208573   EC215295   EC218477   EC234969   GH750974   GH753108   GH753563   GH757818   GH757874   GH770619   GH771085   GH772888   GH774031   GH775107   GH784098   GH786181   GH786329   GH786636   GH790507   GH791009   GH791143   GH791384   GH792350   GH792775   GH793550   GH793582   GH794290   GH794873   GH796191   GH796320   GH796821   GH799803   GH801468   GH802052   GH803053   GH804552   GH809283   GH809995   GH812286   GH813282   GH814255   GH814732   GH815843   GH816442   GH816490   GH816760   GH817902   GH818042   GH818858   GH819159   GH820968   GH821100   GH821993   GH822690   GH823860   GH824357   GH824560   GH826258   GH826425   GH826596   GH826628   GH827707   GH830279   GH833104   GH835739   GH836687   GH837011   GH837869   GH838527   GH838972   GH839809   GH840338   GH840406   GH841809   GH843346   GH843824   GH845187   GH845259   GH847592   GH849279   GH849655   GH854292   GH855722   GH856116   GH858478   GH859610   GH859620   GH860306   GH863072   GH863877   GH864351   GH865479   GH867664   GH867689   GH868241   GH869604   GH874538   GH874871   GH875478   GH881773   GH884271   GH884833   GH886262   GH886897   GH890102   GH893487   GH894528   GH895133   GH896676   GH897418   GH898388   GH899725   GH903554   GH904057   GH905234   GH905915   GH908365   GH909263   GH909826   GH909957   GH910578   GH913835   GH914769   GH915358   GH916634   GH916694   GH916998   GH921549   GH925218   GH925558   GH926363   GH926956   GH928390   GH929422   GH931758   GH931820   GH935817   GH935822   GH937074   GH937873   GH939225   GH939771   GH939798
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VVR2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0259791    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0259791 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0259791 expression level Developmental Stage   Expression Level embryo 00-02hr    4680 embryo 02-04hr    7064 embryo 04-06hr    5666 embryo 06-08hr    4385 embryo 08-10hr    2968 embryo 10-12hr    1524 embryo 12-14hr    960 embryo 14-16hr    1329 embryo 16-18hr    1126 embryo 18-20hr    551 embryo 20-22hr    1768 embryo 22-24hr    1456 larva L1    19 larva L2    26 larva L3 12hr old    74 larva L3 puffstage 1-2    147 larva L3 puffstage 3-6    307 larva L3 puffstage 7-9    369 white prepupae new    372 white prepupae 12hr    811 white prepupae 24hr    857 pupae 2d postWPP    575 pupae 3d postWPP    376 pupae 4d postWPP    332 adult male 01day    487 adult male 05day    927 adult male 30day    799 adult female 01day    620 adult female 05day    1553 adult female 30day    1740 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4680) embryo 02-04hr  (7064) embryo 04-06hr  (5666) embryo 06-08hr  (4385) embryo 08-10hr  (2968) embryo 10-12hr  (1524) embryo 12-14hr  (960) embryo 14-16hr  (1329) embryo 16-18hr  (1126) embryo 18-20hr  (551) embryo 20-22hr  (1768) embryo 22-24hr  (1456) larva L1    19 larva L2    26 larva L3 12hr old    74 larva L3 puffstage 1-2  (147) larva L3 puffstage 3-6  (307) larva L3 puffstage 7-9  (369) white prepupae new  (372) white prepupae 12hr  (811) white prepupae 24hr  (857) pupae 2d postWPP  (575) pupae 3d postWPP  (376) pupae 4d postWPP  (332) adult male 01day  (487) adult male 05day  (927) adult male 30day  (799) adult female 01day  (620) adult female 05day  (1553) adult female 30day  (1740) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4680) embryo 02-04hr  (7064) embryo 04-06hr  (5666) embryo 06-08hr  (4385) embryo 08-10hr  (2968) embryo 10-12hr  (1524) embryo 12-14hr    960 embryo 14-16hr    1329 embryo 16-18hr    1126 embryo 18-20hr    551 embryo 20-22hr  (1768) embryo 22-24hr  1456 larva L1    19 larva L2    26 larva L3 12hr old    74 larva L3 puffstage 1-2    147 larva L3 puffstage 3-6    307 larva L3 puffstage 7-9    369 white prepupae new    372 white prepupae 12hr    811 white prepupae 24hr    857 pupae 2d postWPP    575 pupae 3d postWPP    376 pupae 4d postWPP    332 adult male 01day    487 adult male 05day    927 adult male 30day    799 adult female 01day    620 adult female 05day  (1553) adult female 30day  (1740) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4680 embryo 02-04hr    7064 embryo 04-06hr    5666 embryo 06-08hr    4385 embryo 08-10hr    2968 embryo 10-12hr    1524 embryo 12-14hr    960 embryo 14-16hr    1329 embryo 16-18hr    1126 embryo 18-20hr    551 embryo 20-22hr    1768 embryo 22-24hr    1456 larva L1    19 larva L2    26 larva L3 12hr old    74 larva L3 puffstage 1-2    147 larva L3 puffstage 3-6    307 larva L3 puffstage 7-9    369 white prepupae new    372 white prepupae 12hr    811 white prepupae 24hr    857 pupae 2d postWPP    575 pupae 3d postWPP    376 pupae 4d postWPP    332 adult male 01day    487 adult male 05day    927 adult male 30day    799 adult female 01day    620 adult female 05day    1553 adult female 30day    1740 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4680 embryo 02-04hr    7064 embryo 04-06hr    5666 embryo 06-08hr    4385 embryo 08-10hr    2968 embryo 10-12hr    1524 embryo 12-14hr    960 embryo 14-16hr    1329 embryo 16-18hr    1126 embryo 18-20hr    551 embryo 20-22hr    1768 embryo 22-24hr    1456 larva L1    19 larva L2    26 larva L3 12hr old    74 larva L3 puffstage 1-2    147 larva L3 puffstage 3-6    307 larva L3 puffstage 7-9    369 white prepupae new    372 white prepupae 12hr    811 white prepupae 24hr    857 pupae 2d postWPP    575 pupae 3d postWPP    376 pupae 4d postWPP    332 adult male 01day    487 adult male 05day    927 adult male 30day    799 adult female 01day    620 adult female 05day    1553 adult female 30day    1740 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0259791 expression level Developmental Stage   Expression Level embryo 00-02hr    4680 embryo 02-04hr    7064 embryo 04-06hr    5666 embryo 06-08hr    4385 embryo 08-10hr    2968 embryo 10-12hr    1524 embryo 12-14hr    960 embryo 14-16hr    1329 embryo 16-18hr    1126 embryo 18-20hr    551 embryo 20-22hr    1768 embryo 22-24hr    1456 larva L1    19 larva L2    26 larva L3 12hr old    74 larva L3 puffstage 1-2    147 larva L3 puffstage 3-6    307 larva L3 puffstage 7-9    369 white prepupae new    372 white prepupae 12hr    811 white prepupae 24hr    857 pupae 2d postWPP    575 pupae 3d postWPP    376 pupae 4d postWPP    332 adult male 01day    487 adult male 05day    927 adult male 30day    799 adult female 01day    620 adult female 05day    1553 adult female 30day    1740 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4680) embryo 02-04hr  (7064) embryo 04-06hr  (5666) embryo 06-08hr  (4385) embryo 08-10hr  (2968) embryo 10-12hr  (1524) embryo 12-14hr  (960) embryo 14-16hr  (1329) embryo 16-18hr  (1126) embryo 18-20hr  (551) embryo 20-22hr  (1768) embryo 22-24hr  (1456) larva L1    19 larva L2    26 larva L3 12hr old    74 larva L3 puffstage 1-2  (147) larva L3 puffstage 3-6  (307) larva L3 puffstage 7-9  (369) white prepupae new  (372) white prepupae 12hr  (811) white prepupae 24hr  (857) pupae 2d postWPP  (575) pupae 3d postWPP  (376) pupae 4d postWPP  (332) adult male 01day  (487) adult male 05day  (927) adult male 30day  (799) adult female 01day  (620) adult female 05day  (1553) adult female 30day  (1740) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4680) embryo 02-04hr  (7064) embryo 04-06hr  (5666) embryo 06-08hr  (4385) embryo 08-10hr  (2968) embryo 10-12hr  1524 embryo 12-14hr    960 embryo 14-16hr    1329 embryo 16-18hr    1126 embryo 18-20hr    551 embryo 20-22hr  1768 embryo 22-24hr  1456 larva L1    19 larva L2    26 larva L3 12hr old    74 larva L3 puffstage 1-2    147 larva L3 puffstage 3-6    307 larva L3 puffstage 7-9    369 white prepupae new    372 white prepupae 12hr    811 white prepupae 24hr    857 pupae 2d postWPP    575 pupae 3d postWPP    376 pupae 4d postWPP    332 adult male 01day    487 adult male 05day    927 adult male 30day    799 adult female 01day    620 adult female 05day  1553 adult female 30day  1740 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4680 embryo 02-04hr    7064 embryo 04-06hr    5666 embryo 06-08hr    4385 embryo 08-10hr    2968 embryo 10-12hr    1524 embryo 12-14hr    960 embryo 14-16hr    1329 embryo 16-18hr    1126 embryo 18-20hr    551 embryo 20-22hr    1768 embryo 22-24hr    1456 larva L1    19 larva L2    26 larva L3 12hr old    74 larva L3 puffstage 1-2    147 larva L3 puffstage 3-6    307 larva L3 puffstage 7-9    369 white prepupae new    372 white prepupae 12hr    811 white prepupae 24hr    857 pupae 2d postWPP    575 pupae 3d postWPP    376 pupae 4d postWPP    332 adult male 01day    487 adult male 05day    927 adult male 30day    799 adult female 01day    620 adult female 05day    1553 adult female 30day    1740 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4680 embryo 02-04hr    7064 embryo 04-06hr    5666 embryo 06-08hr    4385 embryo 08-10hr    2968 embryo 10-12hr    1524 embryo 12-14hr    960 embryo 14-16hr    1329 embryo 16-18hr    1126 embryo 18-20hr    551 embryo 20-22hr    1768 embryo 22-24hr    1456 larva L1    19 larva L2    26 larva L3 12hr old    74 larva L3 puffstage 1-2    147 larva L3 puffstage 3-6    307 larva L3 puffstage 7-9    369 white prepupae new    372 white prepupae 12hr    811 white prepupae 24hr    857 pupae 2d postWPP    575 pupae 3d postWPP    376 pupae 4d postWPP    332 adult male 01day    487 adult male 05day    927 adult male 30day    799 adult female 01day    620 adult female 05day    1553 adult female 30day    1740 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0259791    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0259791 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0259791 expression level Tissue   Expression Level Larval Central Nervous System    61.125 Larval Midgut    4.4 Larval Hindgut    6.4 Larval Malpighian Tubules    7.1 Larval Fat Body no informative data Larval Salivary Gland    6.6 Larval Trachea no informative data Larval Carcass    7.45 Adult Head    3.8 Adult Eye    3.375 Adult Brain    3.2 Adult Thoracic-Abdominal Ganglion    6.9 Adult Crop    4.5 Adult Midgut    8.8 Adult Hindgut    5.9 Adult Malpighian Tubules    3.7 Adult Fat Body    6.9 Adult Salivary Gland    4.7 Adult Heart    3.65 Adult VirginFemale Spermatheca    4.2 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    208.9 Adult Testis    156.5 Adult Male Accessory Gland    2.9 Adult Carcass    9.5 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    61.125 Larval Midgut    4.4 Larval Hindgut    6.4 Larval Malpighian Tubules    7.1 Larval Fat Body no informative data Larval Salivary Gland    6.6 Larval Trachea no informative data Larval Carcass    7.45 Adult Head    3.8 Adult Eye    3.375 Adult Brain    3.2 Adult Thoracic-Abdominal Ganglion    6.9 Adult Crop    4.5 Adult Midgut    8.8 Adult Hindgut    5.9 Adult Malpighian Tubules    3.7 Adult Fat Body    6.9 Adult Salivary Gland    4.7 Adult Heart    3.65 Adult VirginFemale Spermatheca    4.2 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    208.9 Adult Testis    156.5 Adult Male Accessory Gland    2.9 Adult Carcass    9.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    61.125 Larval Midgut    4.4 Larval Hindgut    6.4 Larval Malpighian Tubules    7.1 Larval Fat Body no informative data Larval Salivary Gland    6.6 Larval Trachea no informative data Larval Carcass    7.45 Adult Head    3.8 Adult Eye    3.375 Adult Brain    3.2 Adult Thoracic-Abdominal Ganglion    6.9 Adult Crop    4.5 Adult Midgut    8.8 Adult Hindgut    5.9 Adult Malpighian Tubules    3.7 Adult Fat Body    6.9 Adult Salivary Gland    4.7 Adult Heart    3.65 Adult VirginFemale Spermatheca    4.2 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    208.9 Adult Testis    156.5 Adult Male Accessory Gland    2.9 Adult Carcass    9.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    61.125 Larval Midgut    4.4 Larval Hindgut    6.4 Larval Malpighian Tubules    7.1 Larval Fat Body no informative data Larval Salivary Gland    6.6 Larval Trachea no informative data Larval Carcass    7.45 Adult Head    3.8 Adult Eye    3.375 Adult Brain    3.2 Adult Thoracic-Abdominal Ganglion    6.9 Adult Crop    4.5 Adult Midgut    8.8 Adult Hindgut    5.9 Adult Malpighian Tubules    3.7 Adult Fat Body    6.9 Adult Salivary Gland    4.7 Adult Heart    3.65 Adult VirginFemale Spermatheca    4.2 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    208.9 Adult Testis    156.5 Adult Male Accessory Gland    2.9 Adult Carcass    9.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0259791 expression level Tissue   Expression Level Larval Central Nervous System    61.125 Larval Midgut    4.4 Larval Hindgut    6.4 Larval Malpighian Tubules    7.1 Larval Fat Body no informative data Larval Salivary Gland    6.6 Larval Trachea no informative data Larval Carcass    7.45 Adult Head    3.8 Adult Eye    3.375 Adult Brain    3.2 Adult Thoracic-Abdominal Ganglion    6.9 Adult Crop    4.5 Adult Midgut    8.8 Adult Hindgut    5.9 Adult Malpighian Tubules    3.7 Adult Fat Body    6.9 Adult Salivary Gland    4.7 Adult Heart    3.65 Adult VirginFemale Spermatheca    4.2 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    208.9 Adult Testis    156.5 Adult Male Accessory Gland    2.9 Adult Carcass    9.5 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    61.125 Larval Midgut    4.4 Larval Hindgut    6.4 Larval Malpighian Tubules    7.1 Larval Fat Body no informative data Larval Salivary Gland    6.6 Larval Trachea no informative data Larval Carcass    7.45 Adult Head    3.8 Adult Eye    3.375 Adult Brain    3.2 Adult Thoracic-Abdominal Ganglion    6.9 Adult Crop    4.5 Adult Midgut    8.8 Adult Hindgut    5.9 Adult Malpighian Tubules    3.7 Adult Fat Body    6.9 Adult Salivary Gland    4.7 Adult Heart    3.65 Adult VirginFemale Spermatheca    4.2 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    208.9 Adult Testis    156.5 Adult Male Accessory Gland    2.9 Adult Carcass    9.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    61.125 Larval Midgut    4.4 Larval Hindgut    6.4 Larval Malpighian Tubules    7.1 Larval Fat Body no informative data Larval Salivary Gland    6.6 Larval Trachea no informative data Larval Carcass    7.45 Adult Head    3.8 Adult Eye    3.375 Adult Brain    3.2 Adult Thoracic-Abdominal Ganglion    6.9 Adult Crop    4.5 Adult Midgut    8.8 Adult Hindgut    5.9 Adult Malpighian Tubules    3.7 Adult Fat Body    6.9 Adult Salivary Gland    4.7 Adult Heart    3.65 Adult VirginFemale Spermatheca    4.2 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    208.9 Adult Testis    156.5 Adult Male Accessory Gland    2.9 Adult Carcass    9.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    61.125 Larval Midgut    4.4 Larval Hindgut    6.4 Larval Malpighian Tubules    7.1 Larval Fat Body no informative data Larval Salivary Gland    6.6 Larval Trachea no informative data Larval Carcass    7.45 Adult Head    3.8 Adult Eye    3.375 Adult Brain    3.2 Adult Thoracic-Abdominal Ganglion    6.9 Adult Crop    4.5 Adult Midgut    8.8 Adult Hindgut    5.9 Adult Malpighian Tubules    3.7 Adult Fat Body    6.9 Adult Salivary Gland    4.7 Adult Heart    3.65 Adult VirginFemale Spermatheca    4.2 Adult InseminatedFemale Spermatheca    5.7 Adult Ovary    208.9 Adult Testis    156.5 Adult Male Accessory Gland    2.9 Adult Carcass    9.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea no informative data Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    3.8   NA  Eye    3.375   NA  Brain    3.2   61.125  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    6.9   NA  Crop    4.5   4.4  Midgut    8.8   6.4  Hindgut    5.9   7.1  Malpighian Tubules    3.7   no informative data  Fat Body    6.9   6.6  Salivary Gland    4.7   NA  Heart    3.65   no informative data  Trachea    NA   NA  VirginFemale Spermatheca    4.2   NA  InseminatedFemale Spermatheca    5.7   NA  Ovary    208.9   NA  Testis    156.5   NA  Male Accessory Gland    2.9   7.45  Carcass    9.5 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_01
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259791 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6897-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 boraGD12069 lethal | pupal stage (with bora15) bora18 lethal | pupal stage (with bora18) bora15 lethal | pupal stage (with Df(3L)Cat) bora15 bora18 lethal | pupal stage | recessive bora15 bora18 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 boraGD12069 Other Phenotypes Allele neuroanatomy defective | somatic clone boraunspecified visible, with Scer\GAL4pnr-MD237 boraGD12069 visible | somatic clone bora15 bora18 boraunspecified Phenotype manifest in Allele embryonic/larval brain | larval stage, with Scer\GAL41407 boraGD12069 eo neuron | somatic clone boraunspecified head sensillum | somatic clone bora15 bora18 boraunspecified socket | ectopic | somatic clone bora15 bora18 boraunspecified thecogen cell | somatic clone boraunspecified tormogen cell, with Scer\GAL4pnr-MD237 boraGD12069 tormogen cell | ectopic | somatic clone boraunspecified trichogen cell | ectopic | somatic clone bora15 bora18 boraunspecified trichogen cell | supernumerary, with Scer\GAL4pnr-MD237 boraGD12069
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of bora Class Mutagen Stocks Known lesion boraEY21751 P-element activity 1 -- bora15 ethyl methanesulfonate 0 Yes bora18 ethyl methanesulfonate 0 Yes boraunspecified 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of bora Class Mutagen Stocks Known lesion boraGD12069 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes boraScer\UAS.T:Avic\GFP-S65T in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Cat (Hutterer et al., 2006)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{UAS-bora-GFP} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}KG06002 NA insertion of mobile activating element P{EPgy2}boraEY21751 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with UniProtKB:Q9VGF9 (assigned by UniProtKB) (Hutterer et al., 2006)
Biological Process
CV term Evidence References
activation of protein kinase activity inferred from direct assay (assigned by UniProtKB) (Hutterer et al., 2006) asymmetric protein localization involved in cell fate determination inferred from mutant phenotype (Hutterer et al., 2006) peripheral nervous system development inferred from mutant phenotype (Hutterer et al., 2003)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (assigned by UniProtKB) (Hutterer et al., 2006) nucleus inferred from direct assay (assigned by UniProtKB) (Hutterer et al., 2006)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions bora allele Gene References unspecified aur (Hutterer et al., 2006, Hutterer et al., 2003)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65312 DroID - A comprehensive database of gene and protein interactions. • FBgn0259791 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40031
Orthologs
Genome-wide drosophilid orthologs	Dana\GF23632 Dere\GG13667 Dgri\GH16808 Dmoj\GI12212 Dper\GL22884 Dpse\GA19938 Dsec\GM14982 Dsim\GD14759 Dvir\GJ11444 Dwil\GK11230 Dyak\GE19963
Curated drosophilid orthologs	Dpse\GA19938
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL007045-PA Aedes aegypti (mosquito) AGAP012375-PA Anopheles gambiae (mosquito) XP_001121605.1 Apis mellifera (honey bee) 125061 Branchiostoma floridae (lancelet) 125067 Branchiostoma floridae (lancelet) ENSBTAP00000026496 Bos taurus (bovine) CBP19948 Caenorhabditis briggsae (nematode) CE35560 Caenorhabditis elegans (worm) ENSCAFP00000007414 Canis familiaris (dog) CPIJ014090 Culex pipens (mosquito) ENSCPOP00000000796 Cavia porcellus (guinea pig) RP06233 Caenorhabditis remanei (nematode) ENSCSAVP00000007415 Ciona savignyi (sedentary tunicate) 219226 Capitella spl (polychaete worm) ENSECAP00000019561 Equus caballus (horse) ENSGACP00000013046 Gymnopilus aculeatus (mushroom) ENSP00000367046 Homo sapiens (human) 236988 Lottia gigantea (owl limpet) ENSMODP00000036495 Monodelphis domestica (gray opossum) ENSMMUP00000036212 Macaca mulatta (rhesus monkey) ENSMUSP00000022656 Mus musculus (house mouse) ENSOANP00000015896 Ornithorynchus anatinus (platypus) ENSPPYP00000006164 Pongo pygmaeus (orangutan) ENSPTRP00000010069 Pan troglodytes (chimpanzee) ENSRNOP00000035098 Rattus norvegicus (norway rat) XP_001811384.1 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • LH16843 FBgn0237292 FBgn0213241 FBgn0198702 FBgn0186434 FBgn0169903 JGI_V11_333408 FBgn0079934 FBgn0160474 FBgn0134969 FBgn0124279 FBgn0105931 FBgn0100626 CPIJ014090 CPIJ011676 ACYPI37968 GB10618 AGAP012375 AAEL012923 AAEL007045 PB24946 PHUM494530 GLEAN_11843
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	22501 y1 w67c23; P{EPgy2}boraEY21751
VDRC	v35132 w1118; P{GD12069}v35132 v35134 w1118; P{GD12069}v35134
Genomic Clones ( 2 )
	BACR17L05 BACR23M20 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 202 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD27847
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT17049 GM13976 LD01122 LD02254 LD03416 LD05587 LD06762 LD08388 LD08771 LD10969 LD12173 LD13045 LD15367 LD16428 LD18446 LD19315 LD19469 LD23184 LD28853 LD29365 LD29831 LD33416 LD33425 LD33776 LD40081 LD40123 LD44793 LD45396 LD47946 LD47948 RE19110 RE20695 RE22788 RE38790 RE42642 RE42903 RE52172 RE52431 RE57285 RE60929 RE73472 SD27021
Other clones	62024 102881 120349 159226 160950 CK01.50A.F5 CK01.65B.D11 CK01.121B.C7 EK053214 EK062918 EK092712 EK167157 EK173213 EK173247 EK185315 EK200606 EK239828 EK251753 EK265026 LD24066 RP003016617 RP003017134 RP003038548 RP003058250 RP003070901 RP003074821 RP003076626 RP003078444 RP003087238 RP003090550 RP003094873 RP003095154 RP003101387 RP003112644 RP003115238 RP003119656 RP003120836 RP003123202 RP003132313 RP003135482 RP003143302 RP003145586 RP003149487 RP003149876 RP003154127 RP003154666 RP003158915 RP003160895 RP003163772 RP003171494 RP003171706 RP003173920 RP003174085 RP003175496 RP003181716 RP003182759 RP003183195 RP003190608 RP003192827 RP003198218 RP003205088 RP003207304 RP003217874 RP003224609 RP003225717 RP003228631 RP003232969 RP003233652 RP003235101 RP003236806 RP003244826 RP003245807 RP003246507 RP003247317 RP003252666 RP003253531 RP003261193 RP003277917 RP003279284 RP003281509 RP003282016 RP003282077 RP003285702 RP003295521 RP003304184 RP003309609 RP003310453 RP003316640 RP003318808 RP003326765 RP003327482 RP003335249 RP003355062 RP003360606 RP003361379 RP003372074 RP003391792 RP003399839 RP003414762 RP003417358 RP003419458 RP003420479 RP003430976 RP003438529 RP003441980 RP003455869 RP003456945 RP003475722 RP003476873 RP003477170 RP003478017 RP003481635 RP003484603 RP003488922 RP003495011 RP003496756 RP003500356 RP003502744 RP003504440 RP003509152 RP003512213 RP003512447 RP003513512 RP003516854 RP003529188 RP003530050 RP003532124 RP003532547 RP003532603 RP003536161 RP003537496 RP003552246 RP003559186 RP003560010 RP003571053 RP003571369 RP003572516 RP003573430 RP003574254 RP003575553 RP003580033 RP003580543 RP003586633 RP003596199 RP003602610 RP003609627 RP003610813 RP003618122 RP003628591 RP003636561 RP003637770 RP003641351 RP003645257 RP003661749 RP003661946 RP003663428 RP003664791 RP003665888 RP003674120
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0259791 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40031
Antibody Information
Other Information
Discoverer
Etymology
	The gene is named "aurora borealis" to indicate its similarity to the "aurora-A" gene (mutants of both genes have a similar phenotype). (Hutterer et al., 2006)
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: bora CG6897 (Hutterer et al., 2006)
Additional comments
Other Comments
	Identification: in a screen for mutants affecting peripheral nervous system development. (Hutterer et al., 2003) Mutants show cell fate transformations in the peripheral nervous system. (Hutterer et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140791 RefSeq (Proteins) • NP_649048 DDBJ / EMBL / GenBank • AA949088 AAF49248 AAL48019 AW942779 AY070548 Entrez Gene - A searchable database of RefSeq genes. • 40031 UniProtKB/TrEMBL • Q9VVR2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Aurora borealis protein (IPR023252)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65312 DroID - A comprehensive database of gene and protein interactions. • FBgn0259791 DRSC - Results from RNAi screens. • FBgn0259791 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259791 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6897-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0259791 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40031 InParanoid A subset of ortholog calls from InParanoid. • AAEL007045-PA Aedes aegypti (mosquito) AGAP012375-PA Anopheles gambiae (mosquito) XP_001121605.1 Apis mellifera (honey bee) 125061 Branchiostoma floridae (lancelet) 125067 Branchiostoma floridae (lancelet) ENSBTAP00000026496 Bos taurus (bovine) CBP19948 Caenorhabditis briggsae (nematode) CE35560 Caenorhabditis elegans (worm) ENSCAFP00000007414 Canis familiaris (dog) CPIJ014090 Culex pipens (mosquito) ENSCPOP00000000796 Cavia porcellus (guinea pig) RP06233 Caenorhabditis remanei (nematode) ENSCSAVP00000007415 Ciona savignyi (sedentary tunicate) 219226 Capitella spl (polychaete worm) ENSECAP00000019561 Equus caballus (horse) ENSGACP00000013046 Gymnopilus aculeatus (mushroom) ENSP00000367046 Homo sapiens (human) 236988 Lottia gigantea (owl limpet) ENSMODP00000036495 Monodelphis domestica (gray opossum) ENSMMUP00000036212 Macaca mulatta (rhesus monkey) ENSMUSP00000022656 Mus musculus (house mouse) ENSOANP00000015896 Ornithorynchus anatinus (platypus) ENSPPYP00000006164 Pongo pygmaeus (orangutan) ENSPTRP00000010069 Pan troglodytes (chimpanzee) ENSRNOP00000035098 Rattus norvegicus (norway rat) XP_001811384.1 Tribolium castaneum (red flour beetle) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/bora1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40031 modMine - Data generated by the modENCODE project. • FBgn0259791 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • LH16843 FBgn0237292 FBgn0213241 FBgn0198702 FBgn0186434 FBgn0169903 JGI_V11_333408 FBgn0079934 FBgn0160474 FBgn0134969 FBgn0124279 FBgn0105931 FBgn0100626 CPIJ014090 CPIJ011676 ACYPI37968 GB10618 AGAP012375 AAEL012923 AAEL007045 PB24946 PHUM494530 GLEAN_11843
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	bora (Hutterer et al., 2006, Mummery-Widmer et al., 2009) CG6897 (Hutterer et al., 2006, Zhou et al., 2008, Neumüller et al., 2011)
Name Synonym	aurora borealis   borealis (Hutterer et al., 2003) CG6897
Secondary FlyBase IDs
	FBgn0036800 FBgn0064189
References ( 16 )
Research paper	Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Mummery-Widmer et al., 2009, Nature 458(7241): 987--992 Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. [FBrf0207855] Zhou et al., 2008, Mol. Cell 32(4): 592--599 Comparative analysis of argonaute-dependent small RNA pathways in Drosophila. [FBrf0206362] Hutterer et al., 2006, Dev. Cell 11(2): 147--157 Mitotic activation of the kinase Aurora-A requires its binding partner Bora. [FBrf0192833]
Supplementary material	Neumüller et al., 2011, Cell Stem Cell 8(5): Supplemental Table S1. [FBrf0214431] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Bellen, 2006.8.3, MBBatch686_2.xml MBBatch686_2.xml [FBrf0191805]
Abstract	Hutterer et al., 2006, A. Dros. Res. Conf. 47: 153B Mitotic activation of the kinase Aurora-A requires its binding partner Bora. [FBrf0188851] Hutterer et al., 2003, A. Dros. Res. Conf. 44: 43 Nuclear release of the AuroraA binding protein Bora at the onset of mitosis. [FBrf0154487]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]