• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Hip14

General Information
Symbol	Dmel\Hip14	Species	D. melanogaster
Name	Huntingtin-interacting protein 14	Annotation symbol	CG6017
Feature type	protein_coding_gene	FlyBase ID	FBgn0259824
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	dHIP14, l(3)72Ad, CG 6017
Genomic Location
Chromosome (arm)	3L	Recombination map	3-[43]
Cytogenetic map	72C1-72C1	Sequence location	3L:15,981,336..15,985,564 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Huntingtin-interacting protein 14 is referred to in FlyBase by the symbol Dmel\Hip14 (CG6017, FBgn0259824). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: protein-cysteine S-palmitoleyltransferase activity. There is experimental evidence that it is involved in the biological process: synaptic transmission; positive regulation of protein secretion; synaptic vesicle exocytosis. 25 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; intersegmental nerve; embryonic/larval neuromuscular junction. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Ankyrin repeat; Ankyrin repeat-containing domain; Zinc finger, DHHC-type, palmitoyltransferase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult ovary, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1637612_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Hip14. Gene sequence location is 3L:15981336..15985564.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 72C1-72C1   Limits computationally determined from genome sequence between P{EP}Tfb2EP572 and P{lacW}thj5C8&P{PZ}Mbs03802; Left limit from inclusion within Df(3L)Q26 (FBrf0085566) Right limit from non-inclusion within Df(3L)st-f13 (FBrf0072686)
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	3-[43]
Left of (cM)	P{EPgy2}CG31739EY12630 (Ohyama et al., 2007)
Right of (cM)	P{SUPor-P}Pka-C3KG00222 (Ohyama et al., 2007)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Hip14 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.44 Gene model reviewed during 5.46 Stop-codon suppression (UAG) postulated; FBrf0216884. gene_with_stop_codon_read_through ; SO:0000697
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Hip14-RA FBtr0075518  NM_140567   3086   637 Hip14-RB FBtr0330161  NM_001274981   3086   655 Hip14-RC FBtr0333577  NM_001274982   3910   637
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Hip14-PA   FBpp0075273   71.3   637   7.95     NP_648824   AAF49554 Hip14-PB   FBpp0303194   73.3   655   8.03     NP_001261910   AGB94603 Hip14-PC   FBpp0305754   71.3   637   7.95     NP_001261911   AGB94604
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, DHHC-type, palmitoyltransferase (IPR001594) Ankyrin repeat (IPR002110) Ankyrin repeat-containing domain (IPR020683)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA391861   AA567586   AA568027   AA568028   AA735243   AA735244   AA802677   AA802884   AE014296 AAF49554   AE014296 AGB94603   AE014296 AGB94604   AI260953   AW942155   AY094779 AAM11132   AZ300974   BI163564   BI165829   BI169899   BI212983   BI366593   BI369517   BI370516   BI373828   BI577864   BI583597   BI588820   BI636015   BI641140   CL526157   CO153035   CO153047   CO196282   CO269086   CO270550   CO270557   CO272144   CO279519   CO286343   CO286894   CO287524   CO289428   CO290602   CO293246   CO296145   CO314569   CO338551   CZ475810   EC051260   EC052600   EC053281   EC054454   EC055464   EC055492   EC058528   EC059672   EC062158   EC075704   EC079601   EC198341   EC207717   EC208476   EC218849   EC219863   EC232316   EC235291   EC235682   EC242294   EC244719   EC248714   EC250881   EC262572   EC263868   EC264496   EC265407   EV583144   EV594364   GH748087   GH749020   GH749272   GH751903   GH759578   GH771373   GH773925   GH774144   GH775154   GH777608   GH779142   GH780887   GH784283   GH785374   GH786928   GH787858   GH792667   GH793931   GH794699   GH800166   GH801602   GH802508   GH805142   GH809259   GH819348   GH826809   GH827188   GH828658   GH834092   GH834814   GH842553   GH845876   GH849373   GH851242   GH854756   GH856584   GH857337   GH860935   GH861581   GH864982   GH865296   GH868869   GH871537   GH872017   GH872369   GH874294   GH874652   GH875823   GH880760   GH882995   GH884843   GH887071   GH888922   GH891403   GH892613   GH894884   GH898981   GH901487   GH905481   GH906524   GH908077   GH911916   GH913343   GH917025   GH918147   GH919581   GH922371   GH922637   GH922770   GH930231   GH934729   GH935015   GH936456   GH937730
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VUW9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | faint & ubiquitous   (Fisher et al., 2012) pole plasm   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   embryonic central brain neuron   (Fisher et al., 2012) lateral cord neuron   (Fisher et al., 2012) somatic muscle primordium   (Fisher et al., 2012) Comment:reported as muscle system primordium visceral muscle primordium   (Fisher et al., 2012) Comment:reported as muscle system primordium embryonic stage 13 -- 16   embryonic/larval muscle system   (Fisher et al., 2012) embryonic/larval somatic muscle   (Fisher et al., 2012) embryonic/larval visceral muscle   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Golgi apparatus inferred from direct assay (Stowers and Isacoff, 2007, Kang and Bier, 2010, Bannan et al., 2008) synapse inferred from direct assay (Ohyama et al., 2007) synaptic vesicle inferred from direct assay (Stowers and Isacoff, 2007)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult ovary, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    138.45 Larval Midgut    221 Larval Hindgut    190.9 Larval Malpighian Tubules    191 Larval Fat Body    76.8 Larval Salivary Gland    49.5 Larval Trachea    92.375 Larval Carcass    121.875 Adult Head    94.4 Adult Eye    50.4 Adult Brain    116.9 Adult Thoracic-Abdominal Ganglion    104.2 Adult Crop    123.9 Adult Midgut    143 Adult Hindgut    154.5 Adult Malpighian Tubules    167.4 Adult Fat Body    77.6 Adult Salivary Gland    55.1 Adult Heart    68.5 Adult VirginFemale Spermatheca    84 Adult InseminatedFemale Spermatheca    89.9 Adult Ovary    236.7 Adult Testis    14.6 Adult Male Accessory Gland    59.1 Adult Carcass    87.5 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    138.45 Larval Midgut    221 Larval Hindgut    190.9 Larval Malpighian Tubules    191 Larval Fat Body    76.8 Larval Salivary Gland    49.5 Larval Trachea    92.375 Larval Carcass    121.875 Adult Head    94.4 Adult Eye    50.4 Adult Brain    116.9 Adult Thoracic-Abdominal Ganglion    104.2 Adult Crop    123.9 Adult Midgut    143 Adult Hindgut    154.5 Adult Malpighian Tubules    167.4 Adult Fat Body    77.6 Adult Salivary Gland    55.1 Adult Heart    68.5 Adult VirginFemale Spermatheca    84 Adult InseminatedFemale Spermatheca    89.9 Adult Ovary    236.7 Adult Testis    14.6 Adult Male Accessory Gland    59.1 Adult Carcass    87.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    138.45 Larval Midgut    221 Larval Hindgut    190.9 Larval Malpighian Tubules    191 Larval Fat Body    76.8 Larval Salivary Gland    49.5 Larval Trachea    92.375 Larval Carcass    121.875 Adult Head    94.4 Adult Eye    50.4 Adult Brain    116.9 Adult Thoracic-Abdominal Ganglion    104.2 Adult Crop    123.9 Adult Midgut    143 Adult Hindgut    154.5 Adult Malpighian Tubules    167.4 Adult Fat Body    77.6 Adult Salivary Gland    55.1 Adult Heart    68.5 Adult VirginFemale Spermatheca    84 Adult InseminatedFemale Spermatheca    89.9 Adult Ovary    236.7 Adult Testis    14.6 Adult Male Accessory Gland    59.1 Adult Carcass    87.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    138.45 Larval Midgut    221 Larval Hindgut    190.9 Larval Malpighian Tubules    191 Larval Fat Body    76.8 Larval Salivary Gland    49.5 Larval Trachea    92.375 Larval Carcass    121.875 Adult Head    94.4 Adult Eye    50.4 Adult Brain    116.9 Adult Thoracic-Abdominal Ganglion    104.2 Adult Crop    123.9 Adult Midgut    143 Adult Hindgut    154.5 Adult Malpighian Tubules    167.4 Adult Fat Body    77.6 Adult Salivary Gland    55.1 Adult Heart    68.5 Adult VirginFemale Spermatheca    84 Adult InseminatedFemale Spermatheca    89.9 Adult Ovary    236.7 Adult Testis    14.6 Adult Male Accessory Gland    59.1 Adult Carcass    87.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    138.45 Larval Midgut    221 Larval Hindgut    190.9 Larval Malpighian Tubules    191 Larval Fat Body    76.8 Larval Salivary Gland    49.5 Larval Trachea    92.375 Larval Carcass    121.875 Adult Head    94.4 Adult Eye    50.4 Adult Brain    116.9 Adult Thoracic-Abdominal Ganglion    104.2 Adult Crop    123.9 Adult Midgut    143 Adult Hindgut    154.5 Adult Malpighian Tubules    167.4 Adult Fat Body    77.6 Adult Salivary Gland    55.1 Adult Heart    68.5 Adult VirginFemale Spermatheca    84 Adult InseminatedFemale Spermatheca    89.9 Adult Ovary    236.7 Adult Testis    14.6 Adult Male Accessory Gland    59.1 Adult Carcass    87.5 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    138.45 Larval Midgut    221 Larval Hindgut    190.9 Larval Malpighian Tubules    191 Larval Fat Body    76.8 Larval Salivary Gland    49.5 Larval Trachea    92.375 Larval Carcass    121.875 Adult Head    94.4 Adult Eye    50.4 Adult Brain    116.9 Adult Thoracic-Abdominal Ganglion    104.2 Adult Crop    123.9 Adult Midgut    143 Adult Hindgut    154.5 Adult Malpighian Tubules    167.4 Adult Fat Body    77.6 Adult Salivary Gland    55.1 Adult Heart    68.5 Adult VirginFemale Spermatheca    84 Adult InseminatedFemale Spermatheca    89.9 Adult Ovary    236.7 Adult Testis    14.6 Adult Male Accessory Gland    59.1 Adult Carcass    87.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    138.45 Larval Midgut    221 Larval Hindgut    190.9 Larval Malpighian Tubules    191 Larval Fat Body    76.8 Larval Salivary Gland    49.5 Larval Trachea    92.375 Larval Carcass    121.875 Adult Head    94.4 Adult Eye    50.4 Adult Brain    116.9 Adult Thoracic-Abdominal Ganglion    104.2 Adult Crop    123.9 Adult Midgut    143 Adult Hindgut    154.5 Adult Malpighian Tubules    167.4 Adult Fat Body    77.6 Adult Salivary Gland    55.1 Adult Heart    68.5 Adult VirginFemale Spermatheca    84 Adult InseminatedFemale Spermatheca    89.9 Adult Ovary    236.7 Adult Testis    14.6 Adult Male Accessory Gland    59.1 Adult Carcass    87.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    138.45 Larval Midgut    221 Larval Hindgut    190.9 Larval Malpighian Tubules    191 Larval Fat Body    76.8 Larval Salivary Gland    49.5 Larval Trachea    92.375 Larval Carcass    121.875 Adult Head    94.4 Adult Eye    50.4 Adult Brain    116.9 Adult Thoracic-Abdominal Ganglion    104.2 Adult Crop    123.9 Adult Midgut    143 Adult Hindgut    154.5 Adult Malpighian Tubules    167.4 Adult Fat Body    77.6 Adult Salivary Gland    55.1 Adult Heart    68.5 Adult VirginFemale Spermatheca    84 Adult InseminatedFemale Spermatheca    89.9 Adult Ovary    236.7 Adult Testis    14.6 Adult Male Accessory Gland    59.1 Adult Carcass    87.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    94.4   NA  Eye    50.4   NA  Brain    116.9   138.45  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    104.2   NA  Crop    123.9   221  Midgut    143   190.9  Hindgut    154.5   191  Malpighian Tubules    167.4   76.8  Fat Body    77.6   49.5  Salivary Gland    55.1   NA  Heart    68.5   92.375  Trachea    NA   NA  VirginFemale Spermatheca    84   NA  InseminatedFemale Spermatheca    89.9   NA  Ovary    236.7   NA  Testis    14.6   NA  Male Accessory Gland    59.1   121.875  Carcass    87.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    20 central nervous system, pupae P8    21 head, virgin 1-day female    16 head, virgin 4-day female    12 head, virgin 20-day female    13 head, mated 1-day female    10 head, mated 4-day female    11 head, mated 20-day female    11 head, mated 1-day male    17 head, mated 4-day male    17 head, mated 20-day male    16 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    24 digestive system, 1-day adult    13 digestive system, 4-day adult    14 digestive system, 20-day adult    17 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    13 carcass, larvae L3 wandering    14 carcass, 1-day adult    8 carcass, 4-day adult    9 carcass, 20-day adult    11 ovary, virgin 4-day female    46 ovary, mated 4-day female    37 testis, mated 4-day male    4 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    20 central nervous system, pupae P8    21 head, virgin 1-day female    16 head, virgin 4-day female    12 head, virgin 20-day female    13 head, mated 1-day female    10 head, mated 4-day female    11 head, mated 20-day female    11 head, mated 1-day male    17 head, mated 4-day male    17 head, mated 20-day male    16 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    24 digestive system, 1-day adult    13 digestive system, 4-day adult    14 digestive system, 20-day adult    17 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    13 carcass, larvae L3 wandering    14 carcass, 1-day adult    8 carcass, 4-day adult    9 carcass, 20-day adult    11 ovary, virgin 4-day female  (46) ovary, mated 4-day female  (37) testis, mated 4-day male    4 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    20 central nervous system, pupae P8    21 head, virgin 1-day female    16 head, virgin 4-day female    12 head, virgin 20-day female    13 head, mated 1-day female    10 head, mated 4-day female    11 head, mated 20-day female    11 head, mated 1-day male    17 head, mated 4-day male    17 head, mated 20-day male    16 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    24 digestive system, 1-day adult    13 digestive system, 4-day adult    14 digestive system, 20-day adult    17 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    13 carcass, larvae L3 wandering    14 carcass, 1-day adult    8 carcass, 4-day adult    9 carcass, 20-day adult    11 ovary, virgin 4-day female    46 ovary, mated 4-day female    37 testis, mated 4-day male    4 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    20 central nervous system, pupae P8    21 head, virgin 1-day female    16 head, virgin 4-day female    12 head, virgin 20-day female    13 head, mated 1-day female    10 head, mated 4-day female    11 head, mated 20-day female    11 head, mated 1-day male    17 head, mated 4-day male    17 head, mated 20-day male    16 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    24 digestive system, 1-day adult    13 digestive system, 4-day adult    14 digestive system, 20-day adult    17 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    13 carcass, larvae L3 wandering    14 carcass, 1-day adult    8 carcass, 4-day adult    9 carcass, 20-day adult    11 ovary, virgin 4-day female    46 ovary, mated 4-day female    37 testis, mated 4-day male    4 accessory gland, mated 4-day male    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    20 central nervous system, pupae P8    21 head, virgin 1-day female    16 head, virgin 4-day female    12 head, virgin 20-day female    13 head, mated 1-day female    10 head, mated 4-day female    11 head, mated 20-day female    11 head, mated 1-day male    17 head, mated 4-day male    17 head, mated 20-day male    16 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    24 digestive system, 1-day adult    13 digestive system, 4-day adult    14 digestive system, 20-day adult    17 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    13 carcass, larvae L3 wandering    14 carcass, 1-day adult    8 carcass, 4-day adult    9 carcass, 20-day adult    11 ovary, virgin 4-day female    46 ovary, mated 4-day female    37 testis, mated 4-day male    4 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    20 central nervous system, pupae P8    21 head, virgin 1-day female    16 head, virgin 4-day female    12 head, virgin 20-day female    13 head, mated 1-day female    10 head, mated 4-day female    11 head, mated 20-day female    11 head, mated 1-day male    17 head, mated 4-day male    17 head, mated 20-day male    16 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    24 digestive system, 1-day adult    13 digestive system, 4-day adult    14 digestive system, 20-day adult    17 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    13 carcass, larvae L3 wandering    14 carcass, 1-day adult    8 carcass, 4-day adult    9 carcass, 20-day adult    11 ovary, virgin 4-day female  (46) ovary, mated 4-day female  (37) testis, mated 4-day male    4 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    20 central nervous system, pupae P8    21 head, virgin 1-day female    16 head, virgin 4-day female    12 head, virgin 20-day female    13 head, mated 1-day female    10 head, mated 4-day female    11 head, mated 20-day female    11 head, mated 1-day male    17 head, mated 4-day male    17 head, mated 20-day male    16 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    24 digestive system, 1-day adult    13 digestive system, 4-day adult    14 digestive system, 20-day adult    17 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    13 carcass, larvae L3 wandering    14 carcass, 1-day adult    8 carcass, 4-day adult    9 carcass, 20-day adult    11 ovary, virgin 4-day female    46 ovary, mated 4-day female    37 testis, mated 4-day male    4 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    20 central nervous system, pupae P8    21 head, virgin 1-day female    16 head, virgin 4-day female    12 head, virgin 20-day female    13 head, mated 1-day female    10 head, mated 4-day female    11 head, mated 20-day female    11 head, mated 1-day male    17 head, mated 4-day male    17 head, mated 20-day male    16 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    24 digestive system, 1-day adult    13 digestive system, 4-day adult    14 digestive system, 20-day adult    17 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    13 carcass, larvae L3 wandering    14 carcass, 1-day adult    8 carcass, 4-day adult    9 carcass, 20-day adult    11 ovary, virgin 4-day female    46 ovary, mated 4-day female    37 testis, mated 4-day male    4 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    41 embryo 04-06hr    25 embryo 06-08hr    21 embryo 08-10hr    26 embryo 10-12hr    22 embryo 12-14hr    19 embryo 14-16hr    20 embryo 16-18hr    18 embryo 18-20hr    15 embryo 20-22hr    14 embryo 22-24hr    15 larva L1    13 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    13 white prepupae 24hr    14 pupae 2d postWPP    10 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    11 adult male 30day    11 adult female 01day    22 adult female 05day    32 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (51) embryo 02-04hr  (41) embryo 04-06hr    25 embryo 06-08hr    21 embryo 08-10hr  26 embryo 10-12hr    22 embryo 12-14hr    19 embryo 14-16hr    20 embryo 16-18hr    18 embryo 18-20hr    15 embryo 20-22hr    14 embryo 22-24hr    15 larva L1    13 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    13 white prepupae 24hr    14 pupae 2d postWPP    10 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    11 adult male 30day    11 adult female 01day    22 adult female 05day  (32) adult female 30day  (32) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    41 embryo 04-06hr    25 embryo 06-08hr    21 embryo 08-10hr    26 embryo 10-12hr    22 embryo 12-14hr    19 embryo 14-16hr    20 embryo 16-18hr    18 embryo 18-20hr    15 embryo 20-22hr    14 embryo 22-24hr    15 larva L1    13 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    13 white prepupae 24hr    14 pupae 2d postWPP    10 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    11 adult male 30day    11 adult female 01day    22 adult female 05day    32 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    41 embryo 04-06hr    25 embryo 06-08hr    21 embryo 08-10hr    26 embryo 10-12hr    22 embryo 12-14hr    19 embryo 14-16hr    20 embryo 16-18hr    18 embryo 18-20hr    15 embryo 20-22hr    14 embryo 22-24hr    15 larva L1    13 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    13 white prepupae 24hr    14 pupae 2d postWPP    10 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    11 adult male 30day    11 adult female 01day    22 adult female 05day    32 adult female 30day    32 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    41 embryo 04-06hr    25 embryo 06-08hr    21 embryo 08-10hr    26 embryo 10-12hr    22 embryo 12-14hr    19 embryo 14-16hr    20 embryo 16-18hr    18 embryo 18-20hr    15 embryo 20-22hr    14 embryo 22-24hr    15 larva L1    13 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    13 white prepupae 24hr    14 pupae 2d postWPP    10 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    11 adult male 30day    11 adult female 01day    22 adult female 05day    32 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (51) embryo 02-04hr  (41) embryo 04-06hr    25 embryo 06-08hr    21 embryo 08-10hr  26 embryo 10-12hr    22 embryo 12-14hr    19 embryo 14-16hr    20 embryo 16-18hr    18 embryo 18-20hr    15 embryo 20-22hr    14 embryo 22-24hr    15 larva L1    13 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    13 white prepupae 24hr    14 pupae 2d postWPP    10 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    11 adult male 30day    11 adult female 01day    22 adult female 05day  32 adult female 30day  32 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    41 embryo 04-06hr    25 embryo 06-08hr    21 embryo 08-10hr    26 embryo 10-12hr    22 embryo 12-14hr    19 embryo 14-16hr    20 embryo 16-18hr    18 embryo 18-20hr    15 embryo 20-22hr    14 embryo 22-24hr    15 larva L1    13 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    13 white prepupae 24hr    14 pupae 2d postWPP    10 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    11 adult male 30day    11 adult female 01day    22 adult female 05day    32 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    41 embryo 04-06hr    25 embryo 06-08hr    21 embryo 08-10hr    26 embryo 10-12hr    22 embryo 12-14hr    19 embryo 14-16hr    20 embryo 16-18hr    18 embryo 18-20hr    15 embryo 20-22hr    14 embryo 22-24hr    15 larva L1    13 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    13 white prepupae 24hr    14 pupae 2d postWPP    10 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    11 adult male 30day    11 adult female 01day    22 adult female 05day    32 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    32 embryonic 1182-4H    20 embryonic GM2    37 embryonic Kc167    38 embryonic S1    21 embryonic S3    26 leg disc CME L1    25 wing disc CME-W2    32 wing disc ML-DmD8    20 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    9 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    26 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    32 ovary fGS/OSS    7 ovary OSC    6 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4  (32) embryonic 1182-4H    20 embryonic GM2  (37) embryonic Kc167  (38) embryonic S1    21 embryonic S3  26 leg disc CME L1    25 wing disc CME-W2  (32) wing disc ML-DmD8    20 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    9 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5  26 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2  (32) ovary fGS/OSS    7 ovary OSC    6 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    32 embryonic 1182-4H    20 embryonic GM2    37 embryonic Kc167    38 embryonic S1    21 embryonic S3    26 leg disc CME L1    25 wing disc CME-W2    32 wing disc ML-DmD8    20 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    9 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    26 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    32 ovary fGS/OSS    7 ovary OSC    6 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    32 embryonic 1182-4H    20 embryonic GM2    37 embryonic Kc167    38 embryonic S1    21 embryonic S3    26 leg disc CME L1    25 wing disc CME-W2    32 wing disc ML-DmD8    20 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    9 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    26 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    32 ovary fGS/OSS    7 ovary OSC    6 ovary OSS    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    32 embryonic 1182-4H    20 embryonic GM2    37 embryonic Kc167    38 embryonic S1    21 embryonic S3    26 leg disc CME L1    25 wing disc CME-W2    32 wing disc ML-DmD8    20 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    9 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    26 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    32 ovary fGS/OSS    7 ovary OSC    6 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4  32 embryonic 1182-4H    20 embryonic GM2  (37) embryonic Kc167  (38) embryonic S1    21 embryonic S3  26 leg disc CME L1    25 wing disc CME-W2  32 wing disc ML-DmD8    20 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    9 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5  26 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2  32 ovary fGS/OSS    7 ovary OSC    6 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    32 embryonic 1182-4H    20 embryonic GM2    37 embryonic Kc167    38 embryonic S1    21 embryonic S3    26 leg disc CME L1    25 wing disc CME-W2    32 wing disc ML-DmD8    20 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    9 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    26 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    32 ovary fGS/OSS    7 ovary OSC    6 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    32 embryonic 1182-4H    20 embryonic GM2    37 embryonic Kc167    38 embryonic S1    21 embryonic S3    26 leg disc CME L1    25 wing disc CME-W2    32 wing disc ML-DmD8    20 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    9 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    26 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    32 ovary fGS/OSS    7 ovary OSC    6 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    6 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    33 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    22 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    6 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult  (33) Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    22 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3  (30) Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  26 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    6 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    33 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    22 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    6 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    33 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    22 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    6 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    33 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    22 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    6 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult  (33) Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    22 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3  30 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  26 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    6 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    33 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    22 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    6 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    33 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    22 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_01 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	BDGP expression data • LD10758 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259824 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6017-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | first instar larval stage | maternal effect | recessive Hip14ex11 lethal | larval stage | recessive Hip14I25 lethal | pharate adult stage | recessive Hip14ex11 lethal | pupal stage (with Df(3L)brm11) Hip141 Hip142 Hip143 lethal | pupal stage (with Hip141) Hip142 Hip143 lethal | pupal stage (with Hip142) Hip141 Hip143 lethal | pupal stage (with Hip143) Hip141 Hip142 lethal | pupal stage | recessive Hip141 lethal | recessive Hip1472Ad-1 Hip1472Ad-2 viable Hip14EY09853 viable, with Scer\GAL4pnr-MD237 Hip14GD3594 Sterility Allele fertile Hip14EY09853 Other Phenotypes Allele hypoactive | first instar larval stage | maternal effect Hip14ex11 neuroanatomy defective | larval stage, with Scer\GAL4elav-C155 Hip14EP3292 neurophysiology defective | pharate adult stage Hip14ex11 neurophysiology defective | somatic clone Hip141 Hip142 Hip143 Hip14ex11 neurophysiology defective | third instar larval stage (with Df(3L)brm11) Hip141 neurophysiology defective | third instar larval stage | heat sensitive (with Df(3L)brm11) Hip142 uncoordinated | pharate adult stage Hip14ex11 visible, with Scer\GAL4pnr-MD237 Hip14GD3594 Phenotype manifest in Allele anterior fascicle & synapse | supernumerary, with Scer\GAL4elav-C155 Hip14EP3292 embryonic/larval neuromuscular junction (with Df(3L)brm11) Hip141 Hip142 intersegmental nerve, with Scer\GAL4elav-C155 Hip14EP3292 retina | somatic clone Hip14ex11 Hip141 Hip142 Hip143 synapse & eye photoreceptor cell | somatic clone Hip141 Hip142 Hip143 trichogen cell, with Scer\GAL4pnr-MD237 Hip14GD3594
Classical Alleles ( 11 )
For All Classical Alleles Show
Allele of Hip14 Class Mutagen Stocks Known lesion Hip141 ethyl methanesulfonate 1 Yes Hip142 ethyl methanesulfonate 1 Yes Hip14d07562 P-element activity 1 -- Hip14EP3292 P-element activity 1 Yes Hip14EY09853 P-element activity 1 Yes Hip14I25 1 -- Hip143 ethyl methanesulfonate 0 Yes Hip1472Ad-1 ethyl methanesulfonate 0 -- Hip1472Ad-2 ethyl methanesulfonate 0 -- Hip14ex11 loss of function allele P-element activity 0 Yes Hip14unspecified 0 --
Alleles Carried on Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Hip14 Class Mutagen Stocks Known lesion Hip14GD3594 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Hip14HMS01422 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Hip14JF01167 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Hip14KK108236 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Hip14Scer\UAS.cOa in vitro construct - regulatory fusion 1 Yes Hip14+t6.5 in vitro construct - genomic fragment 0 Yes Hip14+tCH322-55J22 in vitro construct - genomic fragment 0 Yes Hip14C.T:Avic\GFP-EGFP in vitro construct - coding region fusion 0 Yes Hip14N.T:Avic\GFP-EGFP in vitro construct - coding region fusion 0 Yes Hip14NIG.6017R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Hip14Scer\UAS.cKa in vitro construct - regulatory fusion 0 Yes Hip14Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Hip14Scer\UAS.T:Disc\RFP-tdTomato in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Hip14T:Avic\GFP-YFP in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)brm11 (Brizuela et al., 1994, Melendez et al., 1995, Ohyama et al., 2007, Cooper and Kennison, 2011) Df(3L)BSC443 (Cooper and Kennison, 2011) Df(3L)BSC774 (Cooper and Kennison, 2011) Df(3L)Q26 (Melendez et al., 1995) Df(3L)th102 (Brizuela et al., 1994, Cooper and Kennison, 2011) Df(3L)X-21.2 (Cooper and Kennison, 2011) Df(3L)XG5 (Cooper and Kennison, 2011)
Not disrupted in	Df(3L)A5 (Melendez et al., 1995) Df(3L)BK10 (Melendez et al., 1995) Df(3L)Brd6 (Melendez et al., 1995) Df(3L)Brd20 (Melendez et al., 1995) Df(3L)st-f13 (Brizuela et al., 1994, Melendez et al., 1995) Df(3L)th117 (Melendez et al., 1995)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK108236} NA P{NIG.6017R} NA P{TRiP.HMS01422} NA P{TRiP.JF01167} NA P{UAS-Hip14.GFP} NA P{UAS-Hip14.K} NA P{UAS-Hip14.O} NA P{UAS-Hip14.TOM} NA characterization construct P{CtermGFP-Hip14} NA P{Hip14+t6.5} NA P{Hip14-YFP.S} NA P{NtermGFP-Hip14} NA PBac{CH322-55J22} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}DNApol-δEP3292 NA P{EPgy2}Hip14EY09853 NA P{XP}Hip14d07562 NA
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
positive regulation of protein secretion inferred from mutant phenotype (Kang and Bier, 2010) synaptic transmission inferred from mutant phenotype (Stowers and Isacoff, 2007, Ohyama et al., 2007) synaptic vesicle exocytosis inferred from mutant phenotype (Ohyama et al., 2007)
Cellular Component
CV term Evidence References
Golgi apparatus inferred from direct assay (Stowers and Isacoff, 2007, Kang and Bier, 2010, Bannan et al., 2008) synapse inferred from direct assay (Ohyama et al., 2007) synaptic vesicle inferred from direct assay (Stowers and Isacoff, 2007)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
protein-cysteine S-palmitoleyltransferase activity inferred from sequence or structural similarity with Saccharomyces ERF2 (Bannan et al., 2008) zinc ion binding inferred from electronic annotation with InterPro:IPR001594 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
protein palmitoylation inferred from sequence or structural similarity with Saccharomyces ERF2 (Bannan et al., 2008)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene   gene_with_stop_codon_read_through (Jungreis et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Hip14 - Atx2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip14 - CG17660 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip14 - CG2064 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip14 - Chc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip14 - Karyβ3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip14 - Mec2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip14 - porin anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip14 - sog anti tag coimmunoprecipitation, anti tag western blot (Kang and Bier, 2010)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Hip14 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65058 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0259824 DroID - A comprehensive database of gene and protein interactions. • FBgn0259824 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39747 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9VUW9
Orthologs
OrthoDB Orthologs (49) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6NKCF1 Dipteran inclusive ortholog search EOG60GCZZ Insect inclusive ortholog search EOG63XSZZ Arthropod inclusive ortholog search EOG6ZCRKX Metazoa inclusive ortholog search EOG6WMHN9
Orthologs in Drosophila Species (EOG6NKCF1)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Hip14     Drosophila simulans   Dsim\GD14587 Y   Drosophila sechellia   Dsec\GM25573     Drosophila erecta   Dere\GG15942 Y   Drosophila yakuba   Dyak\GE22881 Y   Drosophila ananassae   Dana\GF24107 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19299 Y   Drosophila persimilis   Dper\GL12748 Y   Drosophila willistoni   Dwil\GK24504 Y   Drosophila virilis   Dvir\GJ13576 Y   Drosophila mojavensis   Dmoj\GI11882 Y   Drosophila grimshawi   Dgri\GH14779 Y
Orthologs in non-Drosophila Dipterans (EOG60GCZZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL006780   Anopheles gambiae Malaria mosquito  Agam\AGAP011732   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001459   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001460   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001458   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ018286
Orthologs in non-Dipteran Insects (EOG63XSZZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB43411   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG019080   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15352   Atta cephalotes Leafcutter ant  Acep\ACEP12899   Camponotus floridanus Florida carpenter ant  Cflo\CFLO22016   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21827   Linepithema humile Argentine ant  Lhum\LH22932   Pogonomyrmex barbatus Red harvester ant  Pbar\PB25665   Solenopsis invicta Red fire ant  Sinv\SINV17314   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009276   Bombyx mori Silkmoth  Bmor\BGIBMGA001083   Pediculus humanus Human body louse  Phum\PHUM506720   Tribolium castaneum Red flour beetle  Tcas\GLEAN_07009
Orthologs in non-Insect Arthropods (EOG6ZCRKX)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_201447   Ixodes scapularis Deer tick  Isca\ISCW017062
Orthologs in non-Arthropod Metazoa (EOG6WMHN9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\D2021.2   Caenorhabditis elegans Nematode  Cele\H32C10.3   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_021834gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_021833gn   Danio rerio Zebrafish  Drer\zdhhc17   Danio rerio Zebrafish  Drer\zdhhc13   Xenopus tropicalis Western clawed frog  Xtro\zdhhc13   Xenopus tropicalis Western clawed frog  Xtro\zdhhc17   Gallus gallus Domestic chicken  Ggal\ZDHHC17   Gallus gallus Domestic chicken  Ggal\ZDHHC13   Mus musculus House mouse  Mmus\Zdhhc13   Mus musculus House mouse  Mmus\Zdhhc17   Rattus norvegicus Norway rat  Rnor\Zdhhc13   Rattus norvegicus Norway rat  Rnor\Zdhhc17   Homo sapiens Human  Hsap\ZDHHC17   Homo sapiens Human  Hsap\ZDHHC13
Human Orthologs (2)
Gene OMIM HGNC Hsap\ZDHHC17     Hsap\ZDHHC13
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD14587 Drosophila erecta Dere\GG15942 Drosophila yakuba Dyak\GE22881 Drosophila ananassae Dana\GF24107 Drosophila pseudoobscura pseudoobscura Dpse\GA19299 Drosophila persimilis Dper\GL12748 Drosophila willistoni Dwil\GK24504 Drosophila virilis Dvir\GJ13576 Drosophila mojavensis Dmoj\GI11882 Drosophila grimshawi Dgri\GH14779
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	42697 y1 w*; P{UAS-Hip14.O}2 31591 y1 v1; P{TRiP.JF01167}attP2 17614 y1 w67c23; P{EPgy2}Hip14EY09853 35012 y1 sc* v1; P{TRiP.HMS01422}attP2 17109 w1118; P{EP}DNApol-δEP3292 Hip14EP3292 4111 w1118; Hip14I25 P{white-un4}71F/TM3, Sb1 39718 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; Hip141 P{neoFRT}80B/TM3, P{GAL4-Kr.C}DC2, P{UAS-GFP.S65T}DC10, Sb1 39734 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; Hip142 P{neoFRT}80B/TM3, P{GAL4-Kr.C}DC2, P{UAS-GFP.S65T}DC10, Sb1
Harvard	- P{XP}Hip14d07562
VDRC	v101736 P{KK108236}VIE-260B v8487 w1118; P{GD3594}v8487
Genomic Clones ( 1 )
	BACR18K24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 141 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD10758
Other clones	DPiM_LD10758
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM06089 GM06517 HL01487 HL02177 HL02185 LP05005 RE02988 RE05801 RE11204 RE18275 RE52166 RE55724 RE57163 RE61254 RE71622 RH22249 RH30258 SD17574 SD24345
Other clones	8004 21406 33266 46084 66714 73281 80498 117676 193892 521989 522001 524818 572788 CK01.80D.H5 CK01.81C.D5 CK01.90B.F11 CK01.95D.G2 CK01.110A.C3 CK01.110A.E3 CK01.122D.G2 Dmel_dig_008369_0599_1506 Dmel_neb_014117_0624_1701 EC051260 EC052600 EC053281 EC054454 EC055464 EC055492 EK002702 EK062531 EK064215 EK066106 EK071022 EK074443 EK093557 EK099310 EK099318 EK106013 EK134948 EK202236 EK212833 EK237036 EN01135 EN01148 EN17051 LD01664 RP003001940 RP003005066 RP003013218 RP003016300 RP003043824 RP003046288 RP003052491 RP003059262 RP003070463 RP003072383 RP003090323 RP003095200 RP003101112 RP003111933 RP003120893 RP003126080 RP003126981 RP003136012 RP003140686 RP003140982 RP003152752 RP003155214 RP003190276 RP003196861 RP003198774 RP003215870 RP003217008 RP003225781 RP003249975 RP003255780 RP003262437 RP003273814 RP003285998 RP003287795 RP003288157 RP003289680 RP003298394 RP003310785 RP003319609 RP003325864 RP003331734 RP003332360 RP003333688 RP003333909 RP003336071 RP003337746 RP003379086 RP003404490 RP003420222 RP003433787 RP003446733 RP003468280 RP003498967 RP003516455 RP003518078 RP003518548 RP003524708 RP003525298 RP003530380 RP003534130 RP003545348 RP003550482 RP003552529 RP003566187 RP003572749 RP003586959 RP003602185 RP003602930 RP003609371 RP003620611 RP003638155 RP003645642 RP003662031 RP003666722
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0259824 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39747
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Hip14 CG6017 l(3)72Ad (Stowers and Isacoff, 2007)
Source for database merge of	Source for merge of: CG6017 l(3)72Ad (Stowers and Isacoff, 2007)
Additional comments
Other Comments
	The 'l(3)72Ad' (Hip14) complementation group comprises 2 EMS-induced mutant alleles. (Cooper and Kennison, 2011) Hip14 is required in photoreceptors for synapse function and in other neurons for organismal viability. (Stowers and Isacoff, 2007)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140567 NM_001274981 NM_001274982 RefSeq (Proteins) • NP_648824 NP_001261910 NP_001261911 DDBJ / EMBL / GenBank • AA391861 AAF49554 AAM11132 AGB94603 AGB94604 AW942155 AY094779 AZ300974 CL526157 CZ475810 Entrez Gene - A searchable database of RefSeq genes. • 39747 UniProtKB/TrEMBL • Q9VUW9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, DHHC-type, palmitoyltransferase (IPR001594) Ankyrin repeat (IPR002110) Ankyrin repeat-containing domain (IPR020683) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD10758
Linkouts
	BioGRID - A database of protein and genetic interactions • 65058 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0259824 DroID - A comprehensive database of gene and protein interactions. • FBgn0259824 DRSC - Results from RNAi screens. • FBgn0259824 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259824 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6017-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0259824 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39747 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39747 modMine - Data generated by the modENCODE project. • FBgn0259824 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9VUW9
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	3L1 (Ohyama et al., 2007) CG6017 (Ohyama et al., 2007, Stowers and Isacoff, 2007, Bakal et al., 2007, Kang and Bier, 2010, Keleman et al., 2009.8.5, Bannan et al., 2008, Venken et al., 2009, Ni et al., 2008, Ni et al., 2011.7.19, Japanese National Institute of Genetics, 2012.5.21) CG 6017 (Kraut et al., 2001, Kraut et al., 2001) dHIP14 (Stowers and Isacoff, 2007, Kang and Bier, 2010, Bannan et al., 2008) hip14 (Ohyama et al., 2007) Hip14 (Jungreis et al., 2011, Venken et al., 2009, Venken et al., 2009, Cooper and Kennison, 2011) l(3)72Ad (Stowers and Isacoff, 2007, Cooper and Kennison, 2011)
Name Synonym	ankyrin domain (Kraut et al., 2001, Kraut et al., 2001) CG6017   htt-interacting protein 14 (Ohyama et al., 2007) Huntingtin-interacting protein 14 (Stowers and Isacoff, 2007) lethal (3) 72Ad
Secondary FlyBase IDs
	FBgn0004715 FBgn0036555
References ( 33 )
Generate a list of	All references relating to this gene ( 33 )
List References by type	Research paper  ( 11 ) Supplementary material  ( 8 ) Personal communication to FlyBase  ( 9 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 1 ) Book  ( 1 )
Recent research papers ( 2 )
	Lindsley et al., 2013, PLoS ONE 8(2): e55915 Anent the Genomics of Spermatogenesis in Drosophila melanogaster. [FBrf0220812] Cooper and Kennison, 2011, PLoS ONE 6(8): e23509 Molecular Genetic Analyses of Polytene Chromosome Region 72A-D in Drosophila melanogaster Reveal a Gene Desert in 72D. [FBrf0214748] Show all research papers ...