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Gene Dmel\Cap-G

General Information
Symbol	Dmel\Cap-G	Species	D. melanogaster
Name		Annotation symbol	CG34438
Feature type	protein_coding_gene	FlyBase ID	FBgn0259876
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	dcap-g, CG17054, l(2)49Ff, CapG, vr9
Genomic Location
Chromosome (arm)	2R	Recombination map	2-[68]
Cytogenetic map	49E7-49F7	Sequence location	2R:9,020,647..9,030,325 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\Cap-G (CG34438, FBgn0259876). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: mitotic chromosome condensation; mitotic spindle organization; synaptonemal complex disassembly; cytokinesis; sister chromatid segregation; mitotic sister chromatid segregation; neurogenesis. 27 alleles are reported. The phenotypes of these alleles are annotated with: eye; oocyte; mesothoracic tergum; wing; synaptonemal complex. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Armadillo-like helical; Armadillo-type fold; Condensin complex subunit 3; Nuclear condensin complex subunit 3, C-terminal domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult salivary gland, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1629902_at aligns to a genomic region shared by exons of 2 FlyBase-annotated genes; hence it is impossible to interpret the expression pattern and levels of CG34439 expression signal. See the GBrowse view of CG34439 to determine the overlapping gene(s). Gene sequence location is 2R:9020647..9030325.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	l(2)49Ff Embryonic lethal.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 49E7-49F7   Left limit from non-inclusion within Df(2R)vg83f15 (FBrf0048224) Right limit from inclusion within Df(2R)vg33 (FBrf0048224)
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	2-[68]
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Cap-G for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Cap-G-RF FBtr0299507  NM_206105   4387   1351 Cap-G-RG FBtr0301325  NM_001169664   4231   1299
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Cap-G-PF   FBpp0288780   153.9   1351   7.59     NP_995827   AAS64860 Cap-G-PG   FBpp0290540   148.4   1299   7.19     NP_001163135   AAF58425
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Armadillo-type fold (IPR016024) Condensin complex subunit 3 (IPR027165) Armadillo-like helical (IPR011989) Nuclear condensin complex subunit 3, C-terminal domain (IPR025977)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140963   AA390617   AA438778   AA979128   AE013599 AAF58425   AE013599 AAS64860   AI533168   AY061306   BF486567   BF487614   BF488341   BF488553   BF490073   BF491603   BF492119   BF492125   BF494641   BF495346   BF496502   BF498008   BF499625   BF500053   BF500766   BF501043   BF502858   BF504547   BF505004   BF506013   BG637941   BG638708   BG640841   BI235596   BI581919   BI582174   BI611827   BI626050   BT009931   BT032841   CK132511   CO188410   CO267797   CO284113   CO287499   CO304551   CO306908   CO311269   CO325167   CO327929   CO332052   CO338699   CO340463   EC074905   EC210622   EC214689   EC221144   EC232526   EC235782   EC237332   EC239460   EC258791   EV579561   GH747894   GH748198   GH748809   GH749140   GH749835   GH750081   GH750303   GH751793   GH752150   GH752569   GH752813   GH753742   GH755753   GH755837   GH756603   GH756773   GH757640   GH757869   GH760464   GH760856   GH761092   GH770394   GH770457   GH770894   GH771858   GH772248   GH772630   GH772865   GH772962   GH773190   GH773565   GH773660   GH774869   GH775058   GH775094   GH775292   GH775887   GH777029   GH777761   GH778670   GH781635   GH782631   GH783959   GH785035   GH785410   GH786417   GH786967   GH788206   GH788327   GH788415   GH788994   GH789442   GH789622   GH790198   GH790468   GH791691   GH792380   GH793919   GH794097   GH794418   GH794954   GH795010   GH795057   GH795129   GH795347   GH795800   GH796161   GH796365   GH799134   GH799294   GH799450   GH799456   GH799642   GH800774   GH801901   GH802296   GH802629   GH802726   GH804023   GH804026   GH804537   GH805921   GH806383   GH806453   GH806777   GH808053   GH808202   GH812152   GH812177   GH812849   GH813409   GH813540   GH813584   GH814175   GH814512   GH816051   GH817062   GH817890   GH818064   GH818384   GH820185   GH820448   GH821789   GH823328   GH823526   GH823652   GH823687   GH824714   GH824834   GH828471   GH828733   GH828944   GH829132   GH829524   GH829765   GH830288   GH830786   GH830910   GH831104   GH831472   GH832232   GH832443   GH832493   GH832634   GH832995   GH833537   GH834016   GH834962   GH835184   GH835683   GH835842   GH836357   GH837599   GH838033   GH838313   GH838489   GH838517   GH839707   GH842034   GH845577   GH846265   GH846290   GH847143   GH847877   GH848646   GH849198   GH850240   GH850520   GH851192   GH851672   GH851681   GH852615   GH852679   GH852887   GH852995   GH853087   GH853552   GH854548   GH855315   GH856720   GH856983   GH857918   GH858851   GH858920   GH859049   GH859607   GH861811   GH861997   GH862256   GH862322   GH862605   GH862904   GH864051   GH864153   GH865680   GH865750   GH867233   GH867489   GH867658   GH868922   GH869363   GH869460   GH871104   GH871368   GH871459   GH871769   GH871897   GH871977   GH872594   GH873533   GH874181   GH874775   GH875111   GH875167   GH875651   GH876123   GH876397   GH876574   GH877190   GH877729   GH877903   GH878032   GH878605   GH879279   GH879668   GH881266   GH881570   GH881854   GH881861   GH882125   GH882153   GH882335   GH882693   GH885368   GH885729   GH886349   GH887603   GH887702   GH888716   GH888949   GH889339   GH891384   GH891409   GH891440   GH891605   GH892032   GH892184   GH892892   GH893298   GH893616   GH897598   GH897977   GH898058   GH898369   GH899461   GH899798   GH899799   GH900398   GH901435   GH903123   GH903440   GH904211   GH906245   GH907948   GH908231   GH908315   GH909371   GH909901   GH910051   GH910105   GH910300   GH910639   GH911187   GH911343   GH912520   GH913915   GH915899   GH915951   GH916344   GH917598   GH918934   GH919378   GH920092   GH920585   GH921808   GH921880   GH923424   GH924608   GH927137   GH927250   GH927882   GH928661   GH928754   GH928987   GH929703   GH930748   GH930795   GH931785   GH932036   GH932700   GH932862   GH932875   GH933035   GH934689   GH935010   GH937602   GH938353
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	A1Z987 B3DN53
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   central brain primordium   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) RT-PCR Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 16   organism   (Jager et al., 2005) Comment:Cap-G-RF transcript; highest expression at 0-2hr AEL adult stage | male   organism   (Jager et al., 2005) Comment:Cap-G-RF transcript
Additional Descriptive Data
	Cap-G expression is highest at 0-2hr AEL, with levels declining as embryogenesis progresses. Expression is also high in adult males, but undetectable in adult females or in larvae. (Jager et al., 2005)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult salivary gland, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    158 Larval Midgut    33.6 Larval Hindgut    50.7 Larval Malpighian Tubules    39.6 Larval Fat Body    73.8 Larval Salivary Gland    71.1 Larval Trachea    52.4 Larval Carcass    59.95 Adult Head    31.3 Adult Eye    13.825 Adult Brain    59.7 Adult Thoracic-Abdominal Ganglion    56.8 Adult Crop    44.7 Adult Midgut    50.5 Adult Hindgut    52.2 Adult Malpighian Tubules    30.1 Adult Fat Body    42.5 Adult Salivary Gland    113.6 Adult Heart    9.3 Adult VirginFemale Spermatheca    25.2 Adult InseminatedFemale Spermatheca    34.1 Adult Ovary    223.7 Adult Testis    98.3 Adult Male Accessory Gland    54.7 Adult Carcass    56.3 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    158 Larval Midgut    33.6 Larval Hindgut    50.7 Larval Malpighian Tubules    39.6 Larval Fat Body    73.8 Larval Salivary Gland    71.1 Larval Trachea    52.4 Larval Carcass    59.95 Adult Head    31.3 Adult Eye    13.825 Adult Brain    59.7 Adult Thoracic-Abdominal Ganglion    56.8 Adult Crop    44.7 Adult Midgut    50.5 Adult Hindgut    52.2 Adult Malpighian Tubules    30.1 Adult Fat Body    42.5 Adult Salivary Gland    113.6 Adult Heart    9.3 Adult VirginFemale Spermatheca    25.2 Adult InseminatedFemale Spermatheca    34.1 Adult Ovary    223.7 Adult Testis    98.3 Adult Male Accessory Gland    54.7 Adult Carcass    56.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    158 Larval Midgut    33.6 Larval Hindgut    50.7 Larval Malpighian Tubules    39.6 Larval Fat Body    73.8 Larval Salivary Gland    71.1 Larval Trachea    52.4 Larval Carcass    59.95 Adult Head    31.3 Adult Eye    13.825 Adult Brain    59.7 Adult Thoracic-Abdominal Ganglion    56.8 Adult Crop    44.7 Adult Midgut    50.5 Adult Hindgut    52.2 Adult Malpighian Tubules    30.1 Adult Fat Body    42.5 Adult Salivary Gland    113.6 Adult Heart    9.3 Adult VirginFemale Spermatheca    25.2 Adult InseminatedFemale Spermatheca    34.1 Adult Ovary    223.7 Adult Testis    98.3 Adult Male Accessory Gland    54.7 Adult Carcass    56.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    158 Larval Midgut    33.6 Larval Hindgut    50.7 Larval Malpighian Tubules    39.6 Larval Fat Body    73.8 Larval Salivary Gland    71.1 Larval Trachea    52.4 Larval Carcass    59.95 Adult Head    31.3 Adult Eye    13.825 Adult Brain    59.7 Adult Thoracic-Abdominal Ganglion    56.8 Adult Crop    44.7 Adult Midgut    50.5 Adult Hindgut    52.2 Adult Malpighian Tubules    30.1 Adult Fat Body    42.5 Adult Salivary Gland    113.6 Adult Heart    9.3 Adult VirginFemale Spermatheca    25.2 Adult InseminatedFemale Spermatheca    34.1 Adult Ovary    223.7 Adult Testis    98.3 Adult Male Accessory Gland    54.7 Adult Carcass    56.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    158 Larval Midgut    33.6 Larval Hindgut    50.7 Larval Malpighian Tubules    39.6 Larval Fat Body    73.8 Larval Salivary Gland    71.1 Larval Trachea    52.4 Larval Carcass    59.95 Adult Head    31.3 Adult Eye    13.825 Adult Brain    59.7 Adult Thoracic-Abdominal Ganglion    56.8 Adult Crop    44.7 Adult Midgut    50.5 Adult Hindgut    52.2 Adult Malpighian Tubules    30.1 Adult Fat Body    42.5 Adult Salivary Gland    113.6 Adult Heart    9.3 Adult VirginFemale Spermatheca    25.2 Adult InseminatedFemale Spermatheca    34.1 Adult Ovary    223.7 Adult Testis    98.3 Adult Male Accessory Gland    54.7 Adult Carcass    56.3 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    158 Larval Midgut    33.6 Larval Hindgut    50.7 Larval Malpighian Tubules    39.6 Larval Fat Body    73.8 Larval Salivary Gland    71.1 Larval Trachea    52.4 Larval Carcass    59.95 Adult Head    31.3 Adult Eye    13.825 Adult Brain    59.7 Adult Thoracic-Abdominal Ganglion    56.8 Adult Crop    44.7 Adult Midgut    50.5 Adult Hindgut    52.2 Adult Malpighian Tubules    30.1 Adult Fat Body    42.5 Adult Salivary Gland    113.6 Adult Heart    9.3 Adult VirginFemale Spermatheca    25.2 Adult InseminatedFemale Spermatheca    34.1 Adult Ovary    223.7 Adult Testis    98.3 Adult Male Accessory Gland    54.7 Adult Carcass    56.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    158 Larval Midgut    33.6 Larval Hindgut    50.7 Larval Malpighian Tubules    39.6 Larval Fat Body    73.8 Larval Salivary Gland    71.1 Larval Trachea    52.4 Larval Carcass    59.95 Adult Head    31.3 Adult Eye    13.825 Adult Brain    59.7 Adult Thoracic-Abdominal Ganglion    56.8 Adult Crop    44.7 Adult Midgut    50.5 Adult Hindgut    52.2 Adult Malpighian Tubules    30.1 Adult Fat Body    42.5 Adult Salivary Gland    113.6 Adult Heart    9.3 Adult VirginFemale Spermatheca    25.2 Adult InseminatedFemale Spermatheca    34.1 Adult Ovary    223.7 Adult Testis    98.3 Adult Male Accessory Gland    54.7 Adult Carcass    56.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    158 Larval Midgut    33.6 Larval Hindgut    50.7 Larval Malpighian Tubules    39.6 Larval Fat Body    73.8 Larval Salivary Gland    71.1 Larval Trachea    52.4 Larval Carcass    59.95 Adult Head    31.3 Adult Eye    13.825 Adult Brain    59.7 Adult Thoracic-Abdominal Ganglion    56.8 Adult Crop    44.7 Adult Midgut    50.5 Adult Hindgut    52.2 Adult Malpighian Tubules    30.1 Adult Fat Body    42.5 Adult Salivary Gland    113.6 Adult Heart    9.3 Adult VirginFemale Spermatheca    25.2 Adult InseminatedFemale Spermatheca    34.1 Adult Ovary    223.7 Adult Testis    98.3 Adult Male Accessory Gland    54.7 Adult Carcass    56.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    31.3   NA  Eye    no informative data   NA  Brain    59.7   158  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    56.8   NA  Crop    44.7   33.6  Midgut    50.5   50.7  Hindgut    52.2   39.6  Malpighian Tubules    30.1   73.8  Fat Body    no informative data   71.1  Salivary Gland    113.6   NA  Heart    9.3   52.4  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    223.7   NA  Testis    98.3   NA  Male Accessory Gland    54.7   59.95  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    26 central nervous system, pupae P8    5 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    4 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    3 fat body, white prepupae    10 fat body, pupae P8    7 carcass, larvae L3 wandering    16 carcass, 1-day adult    2 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    65 ovary, mated 4-day female    52 testis, mated 4-day male    29 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3  26 central nervous system, pupae P8    5 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    4 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    3 fat body, white prepupae    10 fat body, pupae P8    7 carcass, larvae L3 wandering    16 carcass, 1-day adult    2 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female  (65) ovary, mated 4-day female  (52) testis, mated 4-day male  (29) accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    26 central nervous system, pupae P8    5 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    4 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    3 fat body, white prepupae    10 fat body, pupae P8    7 carcass, larvae L3 wandering    16 carcass, 1-day adult    2 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    65 ovary, mated 4-day female    52 testis, mated 4-day male    29 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    26 central nervous system, pupae P8    5 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    4 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    3 fat body, white prepupae    10 fat body, pupae P8    7 carcass, larvae L3 wandering    16 carcass, 1-day adult    2 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    65 ovary, mated 4-day female    52 testis, mated 4-day male    29 accessory gland, mated 4-day male    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    26 central nervous system, pupae P8    5 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    4 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    3 fat body, white prepupae    10 fat body, pupae P8    7 carcass, larvae L3 wandering    16 carcass, 1-day adult    2 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    65 ovary, mated 4-day female    52 testis, mated 4-day male    29 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3  26 central nervous system, pupae P8    5 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    4 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    3 fat body, white prepupae    10 fat body, pupae P8    7 carcass, larvae L3 wandering    16 carcass, 1-day adult    2 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female  (65) ovary, mated 4-day female  (52) testis, mated 4-day male  29 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    26 central nervous system, pupae P8    5 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    4 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    3 fat body, white prepupae    10 fat body, pupae P8    7 carcass, larvae L3 wandering    16 carcass, 1-day adult    2 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    65 ovary, mated 4-day female    52 testis, mated 4-day male    29 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    26 central nervous system, pupae P8    5 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    4 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    3 fat body, white prepupae    10 fat body, pupae P8    7 carcass, larvae L3 wandering    16 carcass, 1-day adult    2 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    65 ovary, mated 4-day female    52 testis, mated 4-day male    29 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    35 embryo 04-06hr    74 embryo 06-08hr    91 embryo 08-10hr    53 embryo 10-12hr    27 embryo 12-14hr    17 embryo 14-16hr    9 embryo 16-18hr    7 embryo 18-20hr    5 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    4 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    14 white prepupae new    14 white prepupae 12hr    23 white prepupae 24hr    26 pupae 2d postWPP    15 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    12 adult male 05day    17 adult male 30day    17 adult female 01day    17 adult female 05day    35 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (63) embryo 02-04hr  (35) embryo 04-06hr  (74) embryo 06-08hr  (91) embryo 08-10hr  (53) embryo 10-12hr  (27) embryo 12-14hr    17 embryo 14-16hr    9 embryo 16-18hr    7 embryo 18-20hr    5 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    4 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    14 white prepupae new    14 white prepupae 12hr    23 white prepupae 24hr  26 pupae 2d postWPP    15 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    12 adult male 05day    17 adult male 30day    17 adult female 01day    17 adult female 05day  (35) adult female 30day  (37) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    35 embryo 04-06hr    74 embryo 06-08hr    91 embryo 08-10hr    53 embryo 10-12hr    27 embryo 12-14hr    17 embryo 14-16hr    9 embryo 16-18hr    7 embryo 18-20hr    5 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    4 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    14 white prepupae new    14 white prepupae 12hr    23 white prepupae 24hr    26 pupae 2d postWPP    15 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    12 adult male 05day    17 adult male 30day    17 adult female 01day    17 adult female 05day    35 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    35 embryo 04-06hr    74 embryo 06-08hr    91 embryo 08-10hr    53 embryo 10-12hr    27 embryo 12-14hr    17 embryo 14-16hr    9 embryo 16-18hr    7 embryo 18-20hr    5 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    4 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    14 white prepupae new    14 white prepupae 12hr    23 white prepupae 24hr    26 pupae 2d postWPP    15 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    12 adult male 05day    17 adult male 30day    17 adult female 01day    17 adult female 05day    35 adult female 30day    37 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    35 embryo 04-06hr    74 embryo 06-08hr    91 embryo 08-10hr    53 embryo 10-12hr    27 embryo 12-14hr    17 embryo 14-16hr    9 embryo 16-18hr    7 embryo 18-20hr    5 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    4 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    14 white prepupae new    14 white prepupae 12hr    23 white prepupae 24hr    26 pupae 2d postWPP    15 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    12 adult male 05day    17 adult male 30day    17 adult female 01day    17 adult female 05day    35 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (63) embryo 02-04hr  (35) embryo 04-06hr  (74) embryo 06-08hr  (91) embryo 08-10hr  (53) embryo 10-12hr  27 embryo 12-14hr    17 embryo 14-16hr    9 embryo 16-18hr    7 embryo 18-20hr    5 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    4 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    14 white prepupae new    14 white prepupae 12hr    23 white prepupae 24hr  26 pupae 2d postWPP    15 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    12 adult male 05day    17 adult male 30day    17 adult female 01day    17 adult female 05day  (35) adult female 30day  (37) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    35 embryo 04-06hr    74 embryo 06-08hr    91 embryo 08-10hr    53 embryo 10-12hr    27 embryo 12-14hr    17 embryo 14-16hr    9 embryo 16-18hr    7 embryo 18-20hr    5 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    4 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    14 white prepupae new    14 white prepupae 12hr    23 white prepupae 24hr    26 pupae 2d postWPP    15 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    12 adult male 05day    17 adult male 30day    17 adult female 01day    17 adult female 05day    35 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    35 embryo 04-06hr    74 embryo 06-08hr    91 embryo 08-10hr    53 embryo 10-12hr    27 embryo 12-14hr    17 embryo 14-16hr    9 embryo 16-18hr    7 embryo 18-20hr    5 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    4 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    14 white prepupae new    14 white prepupae 12hr    23 white prepupae 24hr    26 pupae 2d postWPP    15 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    12 adult male 05day    17 adult male 30day    17 adult female 01day    17 adult female 05day    35 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    25 embryonic 1182-4H    32 embryonic GM2    19 embryonic Kc167    16 embryonic S1    50 embryonic S3    40 leg disc CME L1    32 wing disc CME-W2    23 wing disc ML-DmD8    26 wing disc ML-DmD9    33 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    23 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    37 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    34 CNS ML-DmBG1-c1    29 CNS ML-DmBG2-c2    36 tumorous blood cells mbn2    16 ovary fGS/OSS    39 ovary OSC    29 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (54) Schneider line 2 Sg4    25 embryonic 1182-4H  (32) embryonic GM2    19 embryonic Kc167    16 embryonic S1  (50) embryonic S3  (40) leg disc CME L1  (32) wing disc CME-W2    23 wing disc ML-DmD8  26 wing disc ML-DmD9  (33) wing disc ML-DmD16-c3  (39) wing disc ML-DmD21    23 wing disc ML-DmD32  (29) haltere disc ML-DmD17-c3  (37) eye-antennal disc ML-DmD11  (29) antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1  (34) CNS ML-DmBG1-c1  (29) CNS ML-DmBG2-c2  (36) tumorous blood cells mbn2    16 ovary fGS/OSS  (39) ovary OSC  (29) ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    25 embryonic 1182-4H    32 embryonic GM2    19 embryonic Kc167    16 embryonic S1    50 embryonic S3    40 leg disc CME L1    32 wing disc CME-W2    23 wing disc ML-DmD8    26 wing disc ML-DmD9    33 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    23 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    37 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    34 CNS ML-DmBG1-c1    29 CNS ML-DmBG2-c2    36 tumorous blood cells mbn2    16 ovary fGS/OSS    39 ovary OSC    29 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    25 embryonic 1182-4H    32 embryonic GM2    19 embryonic Kc167    16 embryonic S1    50 embryonic S3    40 leg disc CME L1    32 wing disc CME-W2    23 wing disc ML-DmD8    26 wing disc ML-DmD9    33 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    23 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    37 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    34 CNS ML-DmBG1-c1    29 CNS ML-DmBG2-c2    36 tumorous blood cells mbn2    16 ovary fGS/OSS    39 ovary OSC    29 ovary OSS    17 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    25 embryonic 1182-4H    32 embryonic GM2    19 embryonic Kc167    16 embryonic S1    50 embryonic S3    40 leg disc CME L1    32 wing disc CME-W2    23 wing disc ML-DmD8    26 wing disc ML-DmD9    33 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    23 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    37 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    34 CNS ML-DmBG1-c1    29 CNS ML-DmBG2-c2    36 tumorous blood cells mbn2    16 ovary fGS/OSS    39 ovary OSC    29 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (54) Schneider line 2 Sg4    25 embryonic 1182-4H  32 embryonic GM2    19 embryonic Kc167    16 embryonic S1  (50) embryonic S3  (40) leg disc CME L1  32 wing disc CME-W2    23 wing disc ML-DmD8  26 wing disc ML-DmD9  (33) wing disc ML-DmD16-c3  (39) wing disc ML-DmD21    23 wing disc ML-DmD32  29 haltere disc ML-DmD17-c3  (37) eye-antennal disc ML-DmD11  29 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1  (34) CNS ML-DmBG1-c1  29 CNS ML-DmBG2-c2  (36) tumorous blood cells mbn2    16 ovary fGS/OSS  (39) ovary OSC  29 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    25 embryonic 1182-4H    32 embryonic GM2    19 embryonic Kc167    16 embryonic S1    50 embryonic S3    40 leg disc CME L1    32 wing disc CME-W2    23 wing disc ML-DmD8    26 wing disc ML-DmD9    33 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    23 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    37 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    34 CNS ML-DmBG1-c1    29 CNS ML-DmBG2-c2    36 tumorous blood cells mbn2    16 ovary fGS/OSS    39 ovary OSC    29 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    25 embryonic 1182-4H    32 embryonic GM2    19 embryonic Kc167    16 embryonic S1    50 embryonic S3    40 leg disc CME L1    32 wing disc CME-W2    23 wing disc ML-DmD8    26 wing disc ML-DmD9    33 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    23 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    37 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    34 CNS ML-DmBG1-c1    29 CNS ML-DmBG2-c2    36 tumorous blood cells mbn2    16 ovary fGS/OSS    39 ovary OSC    29 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    7 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    35 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    7 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult  (34) Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3  (35) Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (32) Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    7 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    35 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    7 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    35 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    7 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    35 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    7 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult  (34) Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3  (35) Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  32 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    7 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    35 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    7 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    35 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_06 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • LD29017 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259876
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Cap-GGD9275 lethal (with Cap-G49Ff-1) Cap-GEP2346 lethal (with Cap-G49Ff-3) Cap-GEP2346 lethal (with Cap-G49Ff-6) Cap-GEP2346 lethal (with Cap-GEP2346) Cap-G49Ff-1 Cap-G49Ff-3 Cap-G49Ff-6 lethal (with Cap-GEP2346), with Scer\GAL4[-]: Cap-GK1 Cap-GK2 lethal (with Cap-GK1), with Scer\GAL4[-]: Cap-GEP2346 lethal (with Cap-GK2), with Scer\GAL4[-]: Cap-GEP2346 lethal | embryonic stage Cap-G49Ff-1 lethal | embryonic stage | recessive Cap-GK4 Cap-GK5 lethal | recessive Cap-G49Ff-1 Cap-G49Ff-3 Cap-G49Ff-4 Cap-G49Ff-5 Cap-G49Ff-6 Cap-G49Ff-7 Cap-G49Ff-8 Cap-GK1 Cap-GK2 partially lethal - majority die | larval stage | recessive Cap-GK3 partially lethal - majority die | recessive | heat sensitive Cap-G49Ff-2 viable, with Scer\GAL4pnr-MD237 Cap-GGD9275 Sterility Allele female sterile Cap-GK3 Cap-GZ1 Cap-GZ2 female sterile (with Cap-GK1) Cap-GZ1 Cap-GZ2 female sterile (with Cap-GZ1) Cap-GK1 female sterile (with Cap-GZ2) Cap-GK1 Other Phenotypes Allele enhancer of variegation, with In(1)wm4h Cap-G64 enhancer of variegation, with P{hsp26-pt-T}39C-72 Cap-G64 enhancer of variegation, with P{hsp26-pt-T}118E-10 Cap-G64 mitotic cell cycle defective Cap-G49Ff-6 Cap-G64 mitotic cell cycle defective (with Cap-G49Ff-3) Cap-G49Ff-6 mitotic cell cycle defective (with Cap-G49Ff-6) Cap-G49Ff-3 neuroanatomy defective | larval stage Cap-GGD9275 suppressor of variegation | dominant, with In(1)wm4h Cap-GK1 Cap-GK2 visible, with Scer\GAL4Bx-MS1096 Cap-GHM04022 visible, with Scer\GAL4pnr-MD237 Cap-GGD9275 visible (with Df(2R)vg56) Cap-GK3 Phenotype manifest in Allele anaphase & condensed nuclear chromosome Cap-GK1 Cap-GK2 anaphase & condensed nuclear chromosome (with Df(2R)vg56) Cap-GK1 Cap-GK3 Cap-GK4 embryonic/larval neuroblast | larval stage Cap-GGD9275 eye (with Df(2R)vg56) Cap-GK3 ganglion mother cell | larval stage Cap-GGD9275 mesothoracic tergum, with Scer\GAL4pnr-MD237 Cap-GGD9275 metaphase & condensed nuclear chromosome (with Df(2R)vg56) Cap-GK3 mitosis & nuclear chromosome Cap-G6 Cap-G64 mitosis & nuclear chromosome (with Df(2R)vg56) Cap-GK3 oocyte (with Cap-GK4) Cap-GZ1 oocyte (with Cap-GZ1) Cap-GK4 prophase & nuclear chromosome (with Df(2R)vg56) Cap-GK4 synaptonemal complex (with Cap-GK4) Cap-GZ1 synaptonemal complex (with Cap-GZ1) Cap-GK4 synaptonemal complex (with Df(2R)vg56) Cap-GK3 telophase & nuclear chromosome (with Df(2R)vg56) Cap-GK4 wing, with Scer\GAL4Bx-MS1096 Cap-GHM04022 wing (with Df(2R)vg56) Cap-GK3
Classical Alleles ( 20 )
For All Classical Alleles Show
Allele of Cap-G Class Mutagen Stocks Known lesion Cap-GEP2346 P-element activity 2 Yes Cap-G49Ff-1 ethyl methanesulfonate 1 Yes Cap-G64 1 Yes Cap-G6 1 -- Cap-Gf05637 piggyBac transposase 1 -- Cap-G49Ff-2 ethyl methanesulfonate 0 -- Cap-G49Ff-3 ethyl methanesulfonate 0 Yes Cap-G49Ff-4 ethyl methanesulfonate 0 -- Cap-G49Ff-5 ethyl methanesulfonate 0 -- Cap-G49Ff-6 ethyl methanesulfonate 0 Yes Cap-G49Ff-7 ethyl methanesulfonate 0 -- Cap-G49Ff-8 gamma ray 0 -- Cap-G49Ff-9 ethyl methanesulfonate 0 -- Cap-GK1 ethyl methanesulfonate 0 -- Cap-GK2 ethyl methanesulfonate 0 -- Cap-GK3 P-element activity 0 Yes Cap-GK4 P-element activity 0 Yes Cap-GK5 P-element activity 0 Yes Cap-GZ1 ethyl methanesulfonate 0 Yes Cap-GZ2 ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Cap-G Class Mutagen Stocks Known lesion Cap-GGD9275 in vitro construct - regulatory fusion in vitro construct - RNAi 1 Yes Cap-GGL00643 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Cap-GHM04022 in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Cap-GKK100392 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Cap-GNIG.17054R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Cap-GScer\UAS.P\T.cJa in vitro construct - regulatory fusion 0 Yes Cap-Gt11.2 in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel8057 (Ryder, 2004.4.26) Df(2R)Su(z)3-1.jtg (Wu and Howe, 1995) Df(2R)vg33 (Dej et al., 2004, Lasko and Pardue, 1988) Df(2R)vg56 (Dej et al., 2004, Lasko and Pardue, 1988, Hao et al., 1995) Df(2R)vg104 (Lasko and Pardue, 1988, Hao et al., 1995) Df(2R)vg106 (Lasko and Pardue, 1988, Hao et al., 1995) Df(2R)vg-B (Dej et al., 2004, Lasko and Pardue, 1988, Wu and Howe, 1995, Hao et al., 1995) Df(2R)vg-P2 (Lasko and Pardue, 1988, Hao et al., 1995)
Not disrupted in	Df(2R)lE107 (Boynton and Tully, 1992) Df(2R)lE388 (Boynton and Tully, 1992) Df(2R)R7 (Lasko and Pardue, 1988) Df(2R)Su(z)2-1.a6 (Wu and Howe, 1995) Df(2R)Su(z)2-1.b8 (Wu and Howe, 1995) Df(2R)Su(z)25 (Wu and Howe, 1995) Df(2R)Su(z)3-1.iy (Wu and Howe, 1995) Df(2R)vg62 (Lasko and Pardue, 1988, Wu and Howe, 1995) Df(2R)vg79b3 (Lasko and Pardue, 1988) Df(2R)vg79d8 (Lasko and Pardue, 1988) Df(2R)vg81 (Lasko and Pardue, 1988) Df(2R)vg83f15 (Lasko and Pardue, 1988) Df(2R)vg107 (Lasko and Pardue, 1988) Df(2R)vg120 (Lasko and Pardue, 1988) Df(2R)vg124 (Lasko and Pardue, 1988) Df(2R)vg133 (Lasko and Pardue, 1988) Df(2R)vg135 (Lasko and Pardue, 1988) Df(2R)vg136 (Lasko and Pardue, 1988, Hao et al., 1995) Df(2R)vg-C (Lasko and Pardue, 1988) Df(2R)vg-D (Lasko and Pardue, 1988, Wu and Howe, 1995) In(2LR)vg79a (Lasko and Pardue, 1988)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK100392} NA P{NIG.17054R} NA P{TRiP.GL00643} NA P{UASp-Cap-G.J} NA characterization construct P{GD9275} NA P{TRiP.HM04022} NA PBac{Cap-Gt11.2} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Cap-GEP2346 NA miscellaneous insertions P{?EP}Cap-GK3 NA P{GT1}BG01873 NA P{wHy}CG34439DG04101 NA PBac{WH}Cap-Gf05637 NA
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cytokinesis inferred from mutant phenotype (Echard et al., 2004) mitotic chromosome condensation inferred from mutant phenotype (Dej et al., 2004, Goshima et al., 2007) mitotic sister chromatid segregation inferred from mutant phenotype (Dej et al., 2004, Jager et al., 2005) mitotic spindle organization inferred from mutant phenotype (Goshima et al., 2007) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) sister chromatid segregation inferred from mutant phenotype (Cobbe et al., 2006) synaptonemal complex disassembly inferred from mutant phenotype (Resnick et al., 2009)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
condensin complex inferred from sequence or structural similarity with human NCAPG (Ono et al., 2003)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Cap-G - CG14141 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cap-G - Gyk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Cap-G allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62209 DroID - A comprehensive database of gene and protein interactions. • FBgn0259876 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36440
Orthologs
OrthoDB Orthologs (50) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6G4H8R Dipteran inclusive ortholog search EOG6BRWTN Insect inclusive ortholog search EOG68CZQG Arthropod inclusive ortholog search EOG6N02W2 Metazoa inclusive ortholog search EOG65J4QF
Orthologs in Drosophila Species (EOG6G4H8R)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Cap-G     Drosophila simulans   Dsim\GD10940 Y   Drosophila sechellia   Dsec\GM21443 Y   Drosophila erecta   Dere\GG20356 Y   Drosophila yakuba   Dyak\GE12515 Y   Drosophila ananassae   Dana\GF12936 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA24748 Y   Drosophila persimilis   Dper\GL11491 Y   Drosophila willistoni   Dwil\GK22222 Y   Drosophila virilis   Dvir\GJ21233 Y   Drosophila mojavensis   Dmoj\GI19984 Y   Drosophila grimshawi   Dgri\GH20312 Y
Orthologs in non-Drosophila Dipterans (EOG6BRWTN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL011049   Anopheles gambiae Malaria mosquito  Agam\AGAP007568   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ007176   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ013419   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ020111   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016393   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ004742   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ017741   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006884
Orthologs in non-Dipteran Insects (EOG68CZQG)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC413691   Apis mellifera Western honey bee  Amel\GB46278   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG012293   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15605   Atta cephalotes Leafcutter ant  Acep\ACEP14985   Camponotus floridanus Florida carpenter ant  Cflo\CFLO12957   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15358   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15359   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15336   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19794   Linepithema humile Argentine ant  Lhum\LH21768   Pogonomyrmex barbatus Red harvester ant  Pbar\PB23691   Solenopsis invicta Red fire ant  Sinv\SINV11864   Acyrthosiphon pisum Pea aphid  Apim\ACYPI008588   Acyrthosiphon pisum Pea aphid  Apim\ACYPI081878   Bombyx mori Silkmoth  Bmor\BGIBMGA012974   Pediculus humanus Human body louse  Phum\PHUM527880   Tribolium castaneum Red flour beetle  Tcas\GLEAN_07921   Tribolium castaneum Red flour beetle  Tcas\TC009926
Orthologs in non-Insect Arthropods (EOG6N02W2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\RPB2   Ixodes scapularis Deer tick  Isca\ISCW005983
Orthologs in non-Arthropod Metazoa (EOG65J4QF)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018309gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_012150gn   Danio rerio Zebrafish  Drer\ncapg   Xenopus tropicalis Western clawed frog  Xtro\ncapg   Gallus gallus Domestic chicken  Ggal\NCAPG   Mus musculus House mouse  Mmus\Ncapg   Rattus norvegicus Norway rat  Rnor\Ncapg   Homo sapiens Human  Hsap\NCAPG
Human Orthologs (1)
Gene OMIM HGNC Hsap\NCAPG
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD10940 Drosophila sechellia Dsec\GM21443 Drosophila erecta Dere\GG20356 Drosophila yakuba Dyak\GE12515 Drosophila ananassae Dana\GF12936 Drosophila pseudoobscura pseudoobscura Dpse\GA24748 Drosophila persimilis Dper\GL11491 Drosophila willistoni Dwil\GK22222 Drosophila virilis Dvir\GJ21233 Drosophila mojavensis Dmoj\GI19984 Drosophila grimshawi Dgri\GH20312
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	17045 w1118; P{EP}Cap-GEP2346/CyO 38204 y1 sc* v1; P{TRiP.GL00643}attP2 5562 al1 b1 Cap-G6 c1 sp1/SM5 5561 al1 b1 Cap-G49Ff-1 c1 sp1/SM5 9456 al1 dpov1 b1 pr1 Cap-G64/CyO, P{en1}wgen11
Harvard	- PBac{WH}Cap-Gf05637
Kyoto	114448 yd2 w1118 P{ey-FLP.N}2; P{neoFRT}42D P{EP}Cap-GEP2346 /CyO y+
VDRC	v40047 w1118; P{GD9275}v40047
Genomic Clones ( 1 )
	BACR48I10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 344 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD22256 LD29017 SD10043
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03343 AT04339 AT06127 AT07159 AT08362 AT10441 AT12359 AT14230 AT14850 AT15789 AT16244 AT18693 AT20901 AT22587 AT23582 AT24017 AT26354 AT28387 AT28993 AT29003 LD13133 LP14078 RE31480 RH18250 RH19751 RH20126 RH66579 SD04908 SD12003
Other clones	11533 28461 38944 67858 74485 108687 145404 192510 214375.42 CK01042 Dmel_dig_017064_0670_1674 EK040028 EK066025 EK151852 EK165303 EK195734 EK224006 EK245054 EK252745 EK302405 EN17428 EP08260 EP10709 LD09638 LD33396 RP003010791 RP003013455 RP003015144 RP003015151 RP003019124 RP003019835 RP003020439 RP003021111 RP003023319 RP003025029 RP003025238 RP003026317 RP003031125 RP003032347 RP003041333 RP003042030 RP003042094 RP003044324 RP003048945 RP003050250 RP003051686 RP003055369 RP003057018 RP003062328 RP003063734 RP003064114 RP003064752 RP003065192 RP003071306 RP003071694 RP003073552 RP003079477 RP003081085 RP003084780 RP003086341 RP003088001 RP003089469 RP003091455 RP003093990 RP003094140 RP003096943 RP003097802 RP003105625 RP003106531 RP003110157 RP003111859 RP003118133 RP003118500 RP003121108 RP003121736 RP003124173 RP003125930 RP003130062 RP003130346 RP003131949 RP003133701 RP003136857 RP003138321 RP003140741 RP003140923 RP003141862 RP003147687 RP003147855 RP003148537 RP003149153 RP003149721 RP003150174 RP003151069 RP003152493 RP003155030 RP003157453 RP003158801 RP003160113 RP003161806 RP003162828 RP003164776 RP003165771 RP003165795 RP003167321 RP003168578 RP003169099 RP003169203 RP003174319 RP003174867 RP003176572 RP003176847 RP003179224 RP003183242 RP003185345 RP003193278 RP003196353 RP003198527 RP003198535 RP003199905 RP003200769 RP003204492 RP003213281 RP003218475 RP003219357 RP003225633 RP003226129 RP003231941 RP003233122 RP003233612 RP003235682 RP003238264 RP003242069 RP003244174 RP003244469 RP003246738 RP003247743 RP003248500 RP003251477 RP003254343 RP003256284 RP003257752 RP003261515 RP003263288 RP003264763 RP003267195 RP003267816 RP003268810 RP003271339 RP003273170 RP003275899 RP003278607 RP003279190 RP003280814 RP003282279 RP003283151 RP003283275 RP003284474 RP003292671 RP003295690 RP003299790 RP003300422 RP003302626 RP003307796 RP003310179 RP003316013 RP003316542 RP003318046 RP003319689 RP003319918 RP003322788 RP003328290 RP003334916 RP003336160 RP003337033 RP003337409 RP003339512 RP003340148 RP003340882 RP003342571 RP003342684 RP003344373 RP003350322 RP003350779 RP003355501 RP003358996 RP003362902 RP003364137 RP003365666 RP003367946 RP003368163 RP003372592 RP003374126 RP003375009 RP003377703 RP003378217 RP003385535 RP003389152 RP003390451 RP003391946 RP003392282 RP003393323 RP003402087 RP003402249 RP003402624 RP003407605 RP003407834 RP003409118 RP003409839 RP003412217 RP003412363 RP003415512 RP003416649 RP003418813 RP003425173 RP003426645 RP003426950 RP003431966 RP003435746 RP003435923 RP003438080 RP003440364 RP003447499 RP003450119 RP003451478 RP003452390 RP003452449 RP003452893 RP003455246 RP003456377 RP003458061 RP003458190 RP003459096 RP003459526 RP003464720 RP003464742 RP003464927 RP003467410 RP003468062 RP003468812 RP003470292 RP003473708 RP003473883 RP003481745 RP003484758 RP003486120 RP003490555 RP003491782 RP003491928 RP003492757 RP003492865 RP003493442 RP003498306 RP003499148 RP003501201 RP003502514 RP003503725 RP003504986 RP003510143 RP003511231 RP003511663 RP003520252 RP003521092 RP003530619 RP003532679 RP003534505 RP003537624 RP003539140 RP003545037 RP003545182 RP003545750 RP003551730 RP003553569 RP003554112 RP003557188 RP003557320 RP003557982 RP003559518 RP003562278 RP003566054 RP003570286 RP003570645 RP003580570 RP003585971 RP003586130 RP003587121 RP003589741 RP003596397 RP003598600 RP003605527 RP003606346 RP003610959 RP003613509 RP003613819 RP003613977 RP003614958 RP003614983 RP003615083 RP003616463 RP003624233 RP003628135 RP003637994 RP003647093 RP003649788 RP003655707 RP003656474 RP003657776 RP003666307 RP003667120 RP003673547 RP003674574 RP003678093 RP003680187
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0259876 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36440
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Cap-G CG17054 (Dej, 2001.3.5)
Source for database merge of	Source for merge of: Cap-G l(2)49Ff (Jager et al., 2005) Source for merge of: CG17054 CG13327 (Whitfield, 2000.12.15)
Additional comments	Annotation CG17054 split into CG34438 (which corresponds to Cap-G) and CG34439 in release 5.2 of the genome annotation. (FlyBase Genome Annotators, 2007) Annotations CG13328 and CG17054 merged as CG17054 in release 3.2 of the genome annotation. (FlyBase Genome Annotators, 2004)
Other Comments
	Cap-G has a role in disassembly of the synaptonemal complex and proper retention of the chromosomes in a metaphase I-arrested state during female meiosis. (Resnick et al., 2009) RNAi screen using dsRNA made from templates generated with primers directed against this gene results in defects in chromosome condensation and chromosome misalignment on the metaphase spindle when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA. (Goshima et al., 2007) Chromosome condensation appears largely unaffected in mutant embryos, while massive defects in sister chromatid segregation occur during mitosis. (Jager et al., 2005) Cap-G is required during mitosis for chromosome condensation during prophase and prometaphase. (Dej et al., 2004) Cap-G mutants show defects in chromosome condensation during prophase and prometaphase, but this defect is resolved by metaphase. Defects in sister chromatid separation are also seen in Cap-G mutants. (Dej et al., 2004) dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells. (Echard et al., 2004) Mutants are embryonic lethal and show defects in chromosome segregation in mitosis. There are no obvious defects in condensation at prophase and metaphase, but chromosome structure is affected, as evidenced by the failure of chromosome arms to separate fully at anaphase. Chromatid separation at the centromere is unaffected, and localization and delocalization of the mei-S332 centromeric cohesion protein is also normal. (Dej and Orr-Weaver, 2001)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_206105 NM_001169664 RefSeq (Proteins) • NP_995827 NP_001163135 DDBJ / EMBL / GenBank • AAF58425 AAS64860 Entrez Gene - A searchable database of RefSeq genes. • 36440 UniProtKB/TrEMBL • A1Z987 B3DN53
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Armadillo-type fold (IPR016024) Condensin complex subunit 3 (IPR027165) Armadillo-like helical (IPR011989) Nuclear condensin complex subunit 3, C-terminal domain (IPR025977) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD29017
Linkouts
	BioGRID - A database of protein and genetic interactions • 62209 DroID - A comprehensive database of gene and protein interactions. • FBgn0259876 DRSC - Results from RNAi screens. • FBgn0259876 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259876 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0259876 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36440 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/cap-g-1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36440 modMine - Data generated by the modENCODE project. • FBgn0259876
Synonyms & Secondary IDs ( 19 )
Reported As
Symbol Synonym	Cap-G (Zahedi et al., 2008, Jager et al., 2005, Nagarkar et al., 2007, Herzog et al., 2008, Georlette et al., 2007, Somma et al., 2008, Friedman et al., 2011, Korenjak et al., 2012) cap-G (Echard et al., 2004, Foglietti et al., 2006) CapG (Asha et al., 2003, McElroy et al., 2008) CAP-G (Goshima et al., 2007, Savvidou et al., 2005) cap-g (Pek and Kai, 2011) CG13327 (Asha et al., 2003) CG17054 (Jager et al., 2005, Ono et al., 2003, Hirano, 2002, Goshima et al., 2007) CG30057   CG34438 (FlyBase Genome Annotators, 2007, Keleman et al., 2009.8.5, Japanese National Institute of Genetics, 2012.5.21, Ni et al., 2010.12.1) dcap-g (Cobbe et al., 2006, Dej and Orr-Weaver, 2003, Resnick et al., 2009) dCAP-G (Dej et al., 2004) DCAP-G (Dej and Orr-Weaver, 2003, Dej and Orr-Weaver, 2001) dCap-G (Longworth et al., 2008) DmCAP-G (Oliveira et al., 2005) l(2)49Ff (Jager et al., 2005, Doheny et al., 2008) l(2)vr9 (Lasko and Pardue, 1988, ) vr9 (Renn et al., 1998, Wu and Howe, 1995) vr-9 (Duronio et al., 1998)
Name Synonym	Cap-G   lethal (2) 49Ff
Secondary FlyBase IDs
	FBan0017054 FBgn0002077 FBgn0033795 FBgn0033796 FBgn0033797 FBgn0050057 FBgn0061377 FBgn0069198 FBgn0085467 FBgn0250905
References ( 54 )
Generate a list of	All references relating to this gene ( 54 )
List References by type	Research paper  ( 28 ) Supplementary material  ( 6 ) Review  ( 1 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 5 ) FlyBase analysis  ( 3 ) Stock list  ( 1 ) Website  ( 1 ) Book  ( 1 )
Recent research papers ( 4 )
	Baradaran-Heravi et al., 2012, Hum. Mol. Genet. 21(11): 2572--2587 Penetrance of biallelic SMARCAL1 mutations is associated with environmental and genetic disturbances of gene expression. [FBrf0218299] Korenjak et al., 2012, Mol. Cell. Biol. 32(21): 4375--4387 RBF Binding to both Canonical E2F Targets and Noncanonical Targets Depends on Functional dE2F/dDP Complexes. [FBrf0219643] Friedman et al., 2011, Sci. Signal. 4(196): rs10 Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling. [FBrf0216513] Pek and Kai, 2011, Curr. Biol. 21(1): 39--44 A role for vasa in regulating mitotic chromosome condensation in Drosophila. [FBrf0212718] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...