mfl, minifly, Uhg6
This is a fused gene: the 3' end corresponds to the non-coding gene Uhg6, which contains one or more snoRNA loci within intronic regions.
Gene model reviewed during 5.42
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.48
Possible mutation in sequenced strain; transposable element after first alternative polyadenylation site may inhibit alternative 3' UTR formation containing downstream snoRNA precursor sequence (Uhg6).
Component of the small nucleolar ribonucleoprotein particle containing H/ACA-type snoRNAs (H/ACA snoRNPs).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Nop60B using the Feature Mapper tool.
Nop60B protein is localized to the nucleolus during interphase. During mitosis the protein is localized throughout the cytoplasm and is absent from the condensed chromosomes. With confocal microscopy, a low level of punctate nuclear staining is seen in addition to the nucleolar staining.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Nop60B in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene results in a change in cell proliferation.
One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders.
Nop60B plays a central role in ribosomal RNA processing and pseudouridylation.