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Gene Dmel\Nop60B

General Information
Symbol	Dmel\Nop60B	Species	D. melanogaster
Name	Nucleolar protein at 60B	Annotation symbol	CG3333
Feature type	protein_coding_gene	FlyBase ID	FBgn0259937
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	mfl
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	60C1-60C2	Sequence location	2R:20,062,248..20,073,866 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Nucleolar protein at 60B is referred to in FlyBase by the symbol Dmel\Nop60B (CG3333, FBgn0259937). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: pseudouridylate synthase activity. There is experimental evidence that it is involved in the biological process: wing disc development; ribosome biogenesis; germ cell development; rRNA processing; pseudouridine synthesis; neurogenesis. 20 alleles are reported. The phenotypes of these alleles are annotated with: organ system; adult segment; organ system subdivision; multicellular structure; thoracic segment; sense organ; eo support cell; adult; imaginal precursor; portion of tissue. It has 7 annotated transcripts and 7 annotated polypeptides. Protein features are: Dyskerin-like; PUA-like domain; Pseudouridine synthase II; Pseudouridine synthase, catalytic domain; Pseudouridine synthase-related; Pseudouridine synthase/archaeosine transglycosylase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, during early larval stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: larval trachea, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval central nervous system, larval/adult midgut, larval hindgut, adult Malpighian tubules, adult heart, adult fat body, larval salivary gland, adult spermathecae, adult male accessory gland, larval/adult carcass. Gene sequence location is 2R:20062248..20073866.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features BKN21291 HFA04627
FB2011_10	Clones GM08026 References Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 60C1-60C2   Limits computationally determined from genome sequence between P{EP}EP503 and P{lacW}Nop60Bk05318
Experimentally Determined Cytological Location
Cytogenetic map Notes References 60B12-60C1     (Giordano, 1998.9.2) 60C1-60C2   (determined by in situ hybridisation)   (Spradling et al., 1999) 60B-60C   (determined by in situ hybridisation)   (Giordano et al., 1999) 60B13-60C1   (determined by in situ hybridisation)   (Phillips et al., 1998) 60C1-60C2     (Beaton, 1997.12.27) 60B12-60B13   60C1--2   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Nop60B for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.42 3' exons correspond to Uhg6 (non-coding).
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Nop60B-RA FBtr0072258  NM_080381   1905   508 Nop60B-RB FBtr0100213  NM_001014547   2370   508 Nop60B-RC FBtr0300227  NM_001169815   2336   508 Nop60B-RD FBtr0300228  NM_001169816   2516   508 Nop60B-RE FBtr0300229  NM_001169817   2757   508 Nop60B-RF FBtr0300861  NM_001169818   3564   508 Nop60B-RG FBtr0304599     1123   227
Additional Transcript Data & Comments
Reported size (kB)	~1.5 (northern blot); 1.7 (longest cDNA) (Phillips et al., 1998) 2.0, 1.8 (northern blot) (Giordano et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Nop60B-PA   FBpp0072166   56.8   508   9.88     NP_525120   AAF47178 Nop60B-PB   FBpp0099583   56.8   508   9.88     NP_001014547   AAX52682 Nop60B-PC   FBpp0289464   56.8   508   9.88     NP_001163286   ACZ94558 Nop60B-PD   FBpp0289465   56.8   508   9.88     NP_001163287   ACZ94559 Nop60B-PE   FBpp0289466   56.8   508   9.88     NP_001163288   ACZ94560 Nop60B-PF   FBpp0290083   56.8   508   9.88     NP_001163289   ACZ94561 Nop60B-PG   FBpp0293141   25.8   227   10.38
Additional Polypeptide Data & Comments
Reported size (kDa)	508 (aa); 56 (kD predicted) (Giordano et al., 1999) 508 (aa) (Phillips et al., 1998)
Comments	Nop60B protein rescues the function of the yeast cbf5 gene. (Phillips et al., 1998)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • PUA-like domain (IPR015947) Pseudouridine synthase/archaeosine transglycosylase (IPR002478) Pseudouridine synthase II (IPR002501) Pseudouridine synthase-related (IPR004802) Dyskerin-like (IPR012960) Pseudouridine synthase, catalytic domain (IPR020103)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA392859   AA441095   AA536558   AA541054   AA567096   AA695793   AA696017   AA696995   AA802546   AA802665   AA802743   AA803219   AA950150   AA951296   AA952067   AE013599 AAF47178   AE013599 AAX52682   AE013599 ACZ94558   AE013599 ACZ94559   AE013599 ACZ94560   AE013599 ACZ94561   AF017230 AAC97117   AF089837 AAD16092   AF097634 AAD19897   AI258139   AI516392   AI546302   AQ025756   AY060937   AY089408 AAL90146   AY805216   BF487909   BF492699   BF492700   BG635440   BG636116   BG640543   BG641367   BG641447   BI141937   BI165668   BI166032   BI166252   BI169096   BI171373   BI212859   BI212910   BI213020   BI213187   BI213208   BI215405   BI216269   BI228056   BI228181   BI228603   BI228723   BI231874   BI232850   BI234509   BI236112   BI237408   BI238587   BI239034   BI241648   BI353074   BI353708   BI353920   BI354088   BI354724   BI354894   BI355006   BI355671   BI356641   BI357382   BI358534   BI361316   BI361421   BI363483   BI365612   BI365642   BI367357   BI367359   BI373881   BI374032   BI374146   BI375485   BI375811   BI572109   BI577275   BI577558   BI577605   BI577884   BI579207   BI606465   BI609295   BI632424   BI635563   BI636358   BP544865   BP549616   BP549617   BP553419   BT030987   BT064644   CK605148   CK605149   CK657904   CO155692   CO155949   CO156228   CO178366   CO178725   CO265841   CO279060   CO281543   CO283373   CO284580   CO284826   CO295287   CO297889   CO297954   CO300636   CO301285   CO303868   CO306774   CO307730   CO310598   CO314122   CO314445   CO316446   CO324467   CO324545   CO327318   CO333609   CO336173   CO336424   CO339468   CO339878   CZ483791   DQ841550 ABH08965   DQ857345 ABI17547   DQ857346 ABI17548   EC056989   EC065430   EC069766   EC074171   EC085143   EC088354   EC199495   EC199906   EC202697   EC203659   EC208887   EC210083   EC214687   EC215573   EC216739   EC221773   EC225789   EC230340   EC234353   EC245693   EC248269   EC254315   EC261201   EC267800   ES692124   EV592907   EV594942   GH951725
UniProtKB/Swiss-Prot	O44081
UniProtKB/TrEMBL	Q95S65 E1JGV6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Giordano et al., 1999) embryonic stage 4 -- 14   organism | ubiquitous   (Phillips et al., 1998) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous   (Phillips et al., 1998) embryonic stage -- adult stage     (Giordano et al., 1999) embryonic stage 1 -- 9     (Giordano et al., 1999) Comment:reference states 0-4 hr AEL oogenesis stage S3 -- S14 & adult stage | female   nurse cell   (Phillips et al., 1998) oocyte   (Phillips et al., 1998) oogenesis   ovary | ubiquitous   (Phillips et al., 1998) ovary   (Giordano et al., 1999) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage & larval stage     (Giordano et al., 1999) embryonic stage 1 -- 9     (Giordano et al., 1999) Comment:reference states 0-4 hr AEL embryonic stage 1 -- 11     (Giordano et al., 1999) Comment:reference states 0-6 hr AEL adult stage | female     (Giordano et al., 1999) adult stage & oogenesis   nurse cell   (Giordano et al., 1999)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous   (Phillips et al., 1998) oogenesis   ovary   (Giordano et al., 1999) immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous   (Phillips et al., 1998) adult stage & oogenesis   germarium   (Phillips et al., 1998) follicle cell   (Phillips et al., 1998) oogenesis   organism | ubiquitous   (Phillips et al., 1998)
Additional Descriptive Data
	Nop60B protein is localized to the nucleolus during interphase. During mitosis the protein is localized throughout the cytoplasm and is absent from the condensed chromosomes. With confocal microscopy, a low level of punctate nuclear staining is seen in addition to the nucleolar staining. (Phillips et al., 1998) Nop60B protein is detected in the nucleus of all cells during oogenesis and embryogenesis. In particular, Nop60B is detected in the nucleoli after cellularization occurs. The Nop60B polyclonal antibody also recognizes antigens localized to the nucleolous of yeast and rat cells. (Phillips et al., 1998)
Marker for
Subcellular Localization
CV Term	nucleolus (Giordano et al., 1999)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0259937    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0259937 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, during early larval stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0259937 expression level Developmental Stage   Expression Level embryo 00-02hr    17805 embryo 02-04hr    7451 embryo 04-06hr    7817 embryo 06-08hr    10489 embryo 08-10hr    10341 embryo 10-12hr    10251 embryo 12-14hr    6650 embryo 14-16hr    4673 embryo 16-18hr    3151 embryo 18-20hr    2799 embryo 20-22hr    6480 embryo 22-24hr    4793 larva L1    10889 larva L2    4651 larva L3 12hr old    2932 larva L3 puffstage 1-2    1019 larva L3 puffstage 3-6    1396 larva L3 puffstage 7-9    1463 white prepupae new    1263 white prepupae 12hr    989 white prepupae 24hr    834 pupae 2d postWPP    766 pupae 3d postWPP    384 pupae 4d postWPP    896 adult male 01day    322 adult male 05day    332 adult male 30day    375 adult female 01day    7632 adult female 05day    12358 adult female 30day    12820 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (17805) embryo 02-04hr  (7451) embryo 04-06hr  (7817) embryo 06-08hr  (10489) embryo 08-10hr  (10341) embryo 10-12hr  (10251) embryo 12-14hr  (6650) embryo 14-16hr  (4673) embryo 16-18hr  (3151) embryo 18-20hr  (2799) embryo 20-22hr  (6480) embryo 22-24hr  (4793) larva L1  (10889) larva L2  (4651) larva L3 12hr old  (2932) larva L3 puffstage 1-2  (1019) larva L3 puffstage 3-6  (1396) larva L3 puffstage 7-9  (1463) white prepupae new  (1263) white prepupae 12hr  (989) white prepupae 24hr  (834) pupae 2d postWPP  (766) pupae 3d postWPP  (384) pupae 4d postWPP  (896) adult male 01day  (322) adult male 05day  (332) adult male 30day  (375) adult female 01day  (7632) adult female 05day  (12358) adult female 30day  (12820) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (17805) embryo 02-04hr  (7451) embryo 04-06hr  (7817) embryo 06-08hr  (10489) embryo 08-10hr  (10341) embryo 10-12hr  (10251) embryo 12-14hr  (6650) embryo 14-16hr  (4673) embryo 16-18hr  (3151) embryo 18-20hr  (2799) embryo 20-22hr  (6480) embryo 22-24hr  (4793) larva L1  (10889) larva L2  (4651) larva L3 12hr old  (2932) larva L3 puffstage 1-2    1019 larva L3 puffstage 3-6    1396 larva L3 puffstage 7-9  1463 white prepupae new    1263 white prepupae 12hr    989 white prepupae 24hr    834 pupae 2d postWPP    766 pupae 3d postWPP    384 pupae 4d postWPP    896 adult male 01day    322 adult male 05day    332 adult male 30day    375 adult female 01day  (7632) adult female 05day  (12358) adult female 30day  (12820) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (17805) embryo 02-04hr    7451 embryo 04-06hr    7817 embryo 06-08hr  10489 embryo 08-10hr  10341 embryo 10-12hr  10251 embryo 12-14hr    6650 embryo 14-16hr    4673 embryo 16-18hr    3151 embryo 18-20hr    2799 embryo 20-22hr    6480 embryo 22-24hr    4793 larva L1  (10889) larva L2    4651 larva L3 12hr old    2932 larva L3 puffstage 1-2    1019 larva L3 puffstage 3-6    1396 larva L3 puffstage 7-9    1463 white prepupae new    1263 white prepupae 12hr    989 white prepupae 24hr    834 pupae 2d postWPP    766 pupae 3d postWPP    384 pupae 4d postWPP    896 adult male 01day    322 adult male 05day    332 adult male 30day    375 adult female 01day    7632 adult female 05day  (12358) adult female 30day  (12820) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    17805 embryo 02-04hr    7451 embryo 04-06hr    7817 embryo 06-08hr    10489 embryo 08-10hr    10341 embryo 10-12hr    10251 embryo 12-14hr    6650 embryo 14-16hr    4673 embryo 16-18hr    3151 embryo 18-20hr    2799 embryo 20-22hr    6480 embryo 22-24hr    4793 larva L1    10889 larva L2    4651 larva L3 12hr old    2932 larva L3 puffstage 1-2    1019 larva L3 puffstage 3-6    1396 larva L3 puffstage 7-9    1463 white prepupae new    1263 white prepupae 12hr    989 white prepupae 24hr    834 pupae 2d postWPP    766 pupae 3d postWPP    384 pupae 4d postWPP    896 adult male 01day    322 adult male 05day    332 adult male 30day    375 adult female 01day    7632 adult female 05day    12358 adult female 30day    12820 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0259937 expression level Developmental Stage   Expression Level embryo 00-02hr    17805 embryo 02-04hr    7451 embryo 04-06hr    7817 embryo 06-08hr    10489 embryo 08-10hr    10341 embryo 10-12hr    10251 embryo 12-14hr    6650 embryo 14-16hr    4673 embryo 16-18hr    3151 embryo 18-20hr    2799 embryo 20-22hr    6480 embryo 22-24hr    4793 larva L1    10889 larva L2    4651 larva L3 12hr old    2932 larva L3 puffstage 1-2    1019 larva L3 puffstage 3-6    1396 larva L3 puffstage 7-9    1463 white prepupae new    1263 white prepupae 12hr    989 white prepupae 24hr    834 pupae 2d postWPP    766 pupae 3d postWPP    384 pupae 4d postWPP    896 adult male 01day    322 adult male 05day    332 adult male 30day    375 adult female 01day    7632 adult female 05day    12358 adult female 30day    12820 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (17805) embryo 02-04hr  (7451) embryo 04-06hr  (7817) embryo 06-08hr  (10489) embryo 08-10hr  (10341) embryo 10-12hr  (10251) embryo 12-14hr  (6650) embryo 14-16hr  (4673) embryo 16-18hr  (3151) embryo 18-20hr  (2799) embryo 20-22hr  (6480) embryo 22-24hr  (4793) larva L1  (10889) larva L2  (4651) larva L3 12hr old  (2932) larva L3 puffstage 1-2  (1019) larva L3 puffstage 3-6  (1396) larva L3 puffstage 7-9  (1463) white prepupae new  (1263) white prepupae 12hr  (989) white prepupae 24hr  (834) pupae 2d postWPP  (766) pupae 3d postWPP  (384) pupae 4d postWPP  (896) adult male 01day  (322) adult male 05day  (332) adult male 30day  (375) adult female 01day  (7632) adult female 05day  (12358) adult female 30day  (12820) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (17805) embryo 02-04hr  (7451) embryo 04-06hr  (7817) embryo 06-08hr  (10489) embryo 08-10hr  (10341) embryo 10-12hr  (10251) embryo 12-14hr  (6650) embryo 14-16hr  (4673) embryo 16-18hr  (3151) embryo 18-20hr  (2799) embryo 20-22hr  (6480) embryo 22-24hr  (4793) larva L1  (10889) larva L2  (4651) larva L3 12hr old  (2932) larva L3 puffstage 1-2    1019 larva L3 puffstage 3-6    1396 larva L3 puffstage 7-9  1463 white prepupae new    1263 white prepupae 12hr    989 white prepupae 24hr    834 pupae 2d postWPP    766 pupae 3d postWPP    384 pupae 4d postWPP    896 adult male 01day    322 adult male 05day    332 adult male 30day    375 adult female 01day  (7632) adult female 05day  (12358) adult female 30day  (12820) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  17805 embryo 02-04hr    7451 embryo 04-06hr    7817 embryo 06-08hr  10489 embryo 08-10hr  10341 embryo 10-12hr  10251 embryo 12-14hr    6650 embryo 14-16hr    4673 embryo 16-18hr    3151 embryo 18-20hr    2799 embryo 20-22hr    6480 embryo 22-24hr    4793 larva L1  10889 larva L2    4651 larva L3 12hr old    2932 larva L3 puffstage 1-2    1019 larva L3 puffstage 3-6    1396 larva L3 puffstage 7-9    1463 white prepupae new    1263 white prepupae 12hr    989 white prepupae 24hr    834 pupae 2d postWPP    766 pupae 3d postWPP    384 pupae 4d postWPP    896 adult male 01day    322 adult male 05day    332 adult male 30day    375 adult female 01day    7632 adult female 05day  12358 adult female 30day  12820 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    17805 embryo 02-04hr    7451 embryo 04-06hr    7817 embryo 06-08hr    10489 embryo 08-10hr    10341 embryo 10-12hr    10251 embryo 12-14hr    6650 embryo 14-16hr    4673 embryo 16-18hr    3151 embryo 18-20hr    2799 embryo 20-22hr    6480 embryo 22-24hr    4793 larva L1    10889 larva L2    4651 larva L3 12hr old    2932 larva L3 puffstage 1-2    1019 larva L3 puffstage 3-6    1396 larva L3 puffstage 7-9    1463 white prepupae new    1263 white prepupae 12hr    989 white prepupae 24hr    834 pupae 2d postWPP    766 pupae 3d postWPP    384 pupae 4d postWPP    896 adult male 01day    322 adult male 05day    332 adult male 30day    375 adult female 01day    7632 adult female 05day    12358 adult female 30day    12820 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0259937    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0259937 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: larval trachea, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval central nervous system, larval/adult midgut, larval hindgut, adult Malpighian tubules, adult heart, adult fat body, larval salivary gland, adult spermathecae, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_08
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259937
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Nop60BDL6 Nop60BDL10 lethal, with Scer\GAL41407 Nop60BGD10940 Nop60BGD16822 lethal, with Scer\GAL4Act5C.PI Nop60BdsRNA.sp.Scer\UAS lethal | embryonic stage | recessive Nop60B3 Nop60B4 Nop60B5 lethal | larval stage, with Scer\GAL4Act5C.PU Nop60BGD16822 lethal | larval stage, with Scer\GAL4ap-md544 Nop60BGD16822 lethal | larval stage | recessive Nop60Bk05318 Nop60Bk06308 lethal | pupal stage | recessive Nop60Bk06308 lethal | recessive Nop60B2 Nop60Bk05318 Nop60Bk06308 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 Nop60BGD10940 viable Nop60B1 Nop60BDL4 viable, with Scer\GAL4pnr-MD237 Nop60BGD16822 Sterility Allele female fertile | reduced, with Scer\GAL4Act5C.PI Nop60BdsRNA.Sym.Scer\UAS female sterile | partially | recessive Nop60B1 male sterile Nop60BDL4 Nop60BmM176 male sterile (with Nop60BDL2011) Nop60BmM176 male sterile (with Nop60BmM176) Nop60BDL2011 sterile Nop60BDL2011 sterile (with In(2LR)Px4) Nop60BDL2011 sterile (with Nop60BDL3) Nop60BDL2011 sterile (with Nop60BDL4) Nop60BDL2011 sterile (with Nop60BDL6) Nop60BDL2011 sterile (with Nop60BDL10) Nop60BDL2011 sterile (with Nop60BDL2011) Nop60BDL3 Nop60BDL4 Nop60BDL6 Nop60BDL10 Other Phenotypes Allele decreased cell size, with Scer\GAL4nub-AC-62 Nop60BGD16822 developmental rate defective, with Scer\GAL4Act5C.PI Nop60BdsRNA.Sym.Scer\UAS developmental rate defective | recessive Nop60B1 increased cell death | recessive Nop60B1 increased cell death | third instar larval stage, with Scer\GAL4ap-md544 Nop60BGD16822 increased cell death | third instar larval stage, with Scer\GAL4en.PU Nop60BGD16822 melanotic mass phenotype | larval stage, with Scer\GAL4Act5C.PU Nop60BGD16822 neuroanatomy defective | larval stage, with Scer\GAL41407 Nop60BGD10940 Nop60BGD16822 small body | larval stage | recessive Nop60Bk05318 Nop60Bk06308 visible, with Scer\GAL4Act5C.PI Nop60BdsRNA.Sym.Scer\UAS visible, with Scer\GAL4Act5C.PU Nop60BGD16822 visible, with Scer\GAL4Bx-MS1096 Nop60BGD16822 visible, with Scer\GAL4en.PU Nop60BGD16822 visible, with Scer\GAL4nub-AC-62 Nop60BGD16822 visible, with Scer\GAL4pnr-MD237 Nop60BdsRNA.sp.Scer\UAS Nop60BdsRNA.Sym.Scer\UAS Nop60BGD10940 Nop60BGD16822 visible, with Scer\GAL4vg.int2.1 Nop60BGD16822 visible | conditional | somatic clone Nop60Bk05318 visible | recessive Nop60B1 Phenotype manifest in Allele adult abdomen & macrochaeta Nop60B1 adult cuticle & adult abdomen Nop60B1 adult cuticle & adult abdomen, with Scer\GAL4Act5C.PI Nop60BdsRNA.Sym.Scer\UAS adult thorax, with Scer\GAL4pnr-MD237 Nop60BdsRNA.sp.Scer\UAS chaeta, with Scer\GAL4Act5C.PI Nop60BdsRNA.Sym.Scer\UAS chaeta, with Scer\GAL4pnr-MD237 Nop60BdsRNA.Sym.Scer\UAS Nop60BdsRNA.sp.Scer\UAS egg Nop60B1 egg chamber Nop60B1 embryo Nop60B1 embryonic/larval neuroblast | larval stage, with Scer\GAL41407 Nop60BGD10940 Nop60BGD16822 ganglion mother cell | larval stage, with Scer\GAL41407 Nop60BGD10940 Nop60BGD16822 germline cell | adult stage | male Nop60BDL4 hub cell Nop60BDL4 male germline stem cell Nop60BDL4 mesothoracic tergum, with Scer\GAL4pnr-MD237 Nop60BGD10940 Nop60BGD16822 nurse cell & nucleus Nop60B1 spermatocyte fusome Nop60BDL4 testis Nop60BDL2011 Nop60BDL4 Nop60BmM176 trichogen cell, with Scer\GAL4pnr-MD237 Nop60BGD10940 wing, with Scer\GAL4ap-md544 Nop60BGD16822 wing, with Scer\GAL4nub-AC-62 Nop60BGD16822 wing | conditional | somatic clone Nop60Bk05318 wing blade, with Scer\GAL4vg.int2.1 Nop60BGD16822 wing disc, with Scer\GAL4ap-md544 Nop60BGD16822 wing disc, with Scer\GAL4en.PU Nop60BGD16822 wing margin, with Scer\GAL4Bx-MS1096 Nop60BGD16822 wing margin, with Scer\GAL4en.PU Nop60BGD16822 wing margin, with Scer\GAL4vg.int2.1 Nop60BGD16822 wing margin bristle, with Scer\GAL4en.PU Nop60BGD16822 wing margin bristle, with Scer\GAL4vg.int2.1 Nop60BGD16822 wing vein, with Scer\GAL4en.PU Nop60BGD16822 wing vein, with Scer\GAL4nub-AC-62 Nop60BGD16822
Classical Alleles ( 14 )
For All Classical Alleles Show
Allele of Nop60B Class Mutagen Stocks Known lesion Nop60Bk05318 P-element activity 2 Yes Nop60Bf01318 piggyBac transposase 1 -- Nop60Bk06308 P-element activity 1 Yes Nop60B1 hypomorphic allele - genetic evidence 0 Yes Nop60B2 Delta2-3 0 Yes Nop60B3 Delta2-3 0 Yes Nop60B4 Delta2-3 0 Yes Nop60B5 Delta2-3 0 Yes Nop60BDL10 Delta2-3 0 -- Nop60BDL2011 hypomorphic allele - genetic evidence P-element activity 0 -- Nop60BDL3 Delta2-3 0 -- Nop60BDL4 Delta2-3 0 Yes Nop60BDL6 Delta2-3 0 -- Nop60BmM176 hypomorphic allele - genetic evidence P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Nop60B Class Mutagen Stocks Known lesion Nop60BGD10940 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Nop60BGD16822 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Nop60BdsRNA.sp.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Nop60BdsRNA.Sym.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Nop60Bhs.PG in vitro construct - regulatory fusion 0 Yes Nop60BKK101240 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)BSC155 (Christensen and Cook, 2006.5.11) Df(2R)Exel6081 (Ryder, 2004.4.26) Df(2R)Exel7184 (Ryder, 2004.4.26) In(2LR)Px4 (Phillips et al., 1998, Giordano et al., 1999, Spradling et al., 1999, Kauffman et al., 2003, BDGP Project Members, 1994-1999)
Not disrupted in	Df(2R)bwVDe2LPxKR (Spradling et al., 1999, Beaton, 1997.12.27) Df(2R)Px2 (Spradling et al., 1999, Kauffman et al., 2003, BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10940} NA P{GD16822} NA P{KK101240} NA P{Sym-UAS-Nop60B} NA P{UAS-IR-Nop60B.sp} NA heat-shock construct P{hs-Nop60B.G} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}l(2)SH0265SH0265 No P{lacW}Nop60BDL2011 No P{lacW}Nop60Bk05318 No P{lacW}Nop60Bk06308 No P{lacW}Nop60BmM176 No P{PZ}Nop60B1 No miscellaneous insertions PBac{WH}Nop60Bf01318 NA
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
germ cell development inferred from mutant phenotype (Kauffman et al., 2003) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) pseudouridine synthesis inferred from mutant phenotype (Giordano et al., 1999) ribosome biogenesis inferred from mutant phenotype (Giordano et al., 1999) rRNA processing inferred from mutant phenotype (Giordano et al., 1999) wing disc development inferred from mutant phenotype (Tortoriello et al., 2010)
Cellular Component
CV term Evidence References
nucleolus inferred from direct assay (Giordano et al., 1999)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
pseudouridine synthase activity inferred from electronic annotation with InterPro:IPR020103 (FlyBase Curators et al., 2004-) pseudouridylate synthase activity inferred from sequence or structural similarity (Swiss-Prot Project Members, 2001.8.20) RNA binding inferred from electronic annotation with InterPro:IPR002478, InterPro:IPR020103 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
rRNA processing non-traceable author statement (Swiss-Prot Project Members, 2001.8.20)
Cellular Component
CV term Evidence References
nucleolus inferred from sequence or structural similarity with NCBI_gi:1083739 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 2001.8.20) nucleus non-traceable author statement (Swiss-Prot Project Members, 2001.8.20)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Nop60B allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63449 DroID - A comprehensive database of gene and protein interactions. • FBgn0259937 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37873
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11381 Dere\GG22950 Dgri\GH20974 Dmoj\GI21310 Dper\GL19980 Dpse\GA24087 Dsec\GM18314 Dsim\GD11839 Dvir\GJ21579 Dyak\GE14387
Curated drosophilid orthologs	Dpse\GA17386
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL003514-PA Aedes aegypti (mosquito) AGAP004739-PA Anopheles gambiae (mosquito) XP_397244.3 Apis mellifera (honey bee) XP_001951759.1 Acyrthosiphon pisum (pea aphid) At3g57150.1 Arabidopsis thaliana (wall cress) 16206 Batrachochytrium dendrobatidis (chytrid fungus) 71433 Branchiostoma floridae (lancelet) BGIBMGA003833-PA Bombyx mori (silk worm) ENSBTAP00000017339 Bos taurus (bovine) CAL0001653 Candida albicans (a form of yeast) CN05538 Caenorhabditis brenneri (small nematode) CBP04263 Caenorhabditis briggsae (nematode) CE16195 Caenorhabditis elegans (worm) ENSCAFP00000029020 Canis familiaris (dog) CAGL0H03685g Candida glabrata (haploid yeast) Chro.30435 Cryptosporidium hominis (obligate parasite) ENSCINP00000009502 Ciona intestinalis (sea squirt) JA09222 Caenorhabditis japonica (nematode) CMM044C Cyanidioschyzon merolae (red alga) cn04348 Cryptococcus neoformans (yeast-like fungus) cgd3_3850 Cryptosporidium parvum (protozoan parasite) CPIJ000795 Culex pipens (mosquito) CPIJ006466 Culex pipens (mosquito) ENSCPOP00000007923 Cavia porcellus (guinea pig) 99415 Chlamidomonas reinhardtii (green alga) RP26239 Caenorhabditis remanei (nematode) ENSCSAVP00000017089 Ciona savignyi (sedentary tunicate) 226101 Capitella spl (polychaete worm) DDB0233679 Dictyostelium discoideum (amoeba) DEHA2G11748g Debaryomyces Hansenii (yeast) 228342 Daphnia pulex (daphnia) ENSDARP00000007628 Danio rerio (zebra fish) ENSECAP00000021150 Equus caballus (horse) XP_649989 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000005785 Gymnopilus aculeatus (mushroom) ENSGALP00000008091 Gallus gallus (chicken) GL50803_16311 Giardia lamblia (flagellated protozoan) 113964 Hypsipyla robusta (cedar shoot borer) ENSP00000377168 Homo sapiens (human) ISCW017820-PA Ixodes scapularis (deer tick) KLLA0D04796g Kluyveromyces lactis (yeast) 139266 Lottia gigantea (owl limpet) LmjF21.1760 Leishmania major (virus) 17370 Monocosta brevicollis (choanoflagellate) ENSMODP00000011539 Monodelphis domestica (gray opossum) ENSMMUP00000007617 Macaca mulatta (rhesus monkey) ENSMUSP00000033776 Mus musculus (house mouse) 92827 Nematostella vectensis (starlet anemone) ENSOANP00000013881 Ornithorynchus anatinus (platypus) ENSORLP00000023417 Oryzias latipes (japanese killifish) LOC_Os03g25450.1 Oryza sativa (asian rice) 30756 Ostreococcus tauri (green alga) PF14_0174 Plasmodium falciparum (protozoal parasite) PHUM010025-PA Pediculus humanus (human body louse) PP18907 Pristionchus pacificus (nematode) 195956 Physcomitrella patens (moss) ENSPPYP00000023387 Pongo pygmaeus (orangutan) 71515 Phytophthora ramorum (sudden oak death pathogen) 156946 Phytophthora sojae (root rot pathogen) 417935 Populus trichocarpa (black cottonwood) ENSPTRP00000059699 Pan troglodytes (chimpanzee) PVX_085575 Plasmodium vivax (protozoal parasite) 4876587 Sorghum bicolor (sorghum) YLR175W Saccharomyces cerevisiae (budding yeast) Smp_068920.2 Schistosoma mansoni (trematode parasite) SPAC29A4.04c Schizosaccharomyces pombe (fission yeast) XP_789483.2 Strongylocentrotus purpuratus (purple sea urchin) 19124 Trichoplax adhaerens (metazoa) TA13560 Theileria annulata (apicomplexan parasite) XP_967291.1 Tribolium castaneum (red flour beetle) Tc00.1047053504069.90 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511145.70 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000005134 Tetraodon nigroviridis (green spotted pufferfish) TP02_0508 Theileria parva (parasitic protozoan) 508 Thalassiosira pseudonana (marine diatom) ENSTRUP00000010488 Takifugu rubripes (pufferfish Takifugu) 7.m00302 Tetrahymena thermophila (ciliate protozoa) 94275.m00107 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000051364 Xenopus tropicalis (frog) YALI0E13486g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16557 NV51120 LH24383 ISCW017820 FBgn0231995 FBgn0208698 FBgn0183578 FBgn0173221 JGI_V11_228342 FBgn0245486 FBgn0157577 FBgn0144040 FBgn0128436 FBgn0115107 FBgn0088421 CPIJ006466 CPIJ000795 BGIBMGA003833 ACYPI008354 ACYPI001882 GB11348 AGAP004739 AAEL003514 PHUM464860 GLEAN_10569
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	12202 y1 w67c23; P{lacW}Nop60Bk05318/CyO
Harvard	- PBac{WH}Nop60Bf01318
Kyoto	102462 y1 w67c23 ; P{lacW}Nop60Bk06308 / CyO 111448 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{neoFRT}42D P{lacW}Nop60Bk05318 /CyO y+
VDRC	v34597 w1118; P{GD10940}v34597 v46279 w1118; P{GD16822}v46279 v46282 w1118; P{GD16822}v46282 v34598 w1118; P{GD10940}v34598/CyO
Genomic Clones ( 2 )
	BACR04P18 BACR27M17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 150 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT23018 GM08026 LD07711
Other clones	MIP05689
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM01060 GM04478 GM04914 GM05796 GM06075 GM06244 GM08871 GM10417 GM22118 GM24818 GM25604 GM26228 GM28058 GM28739 GM29187 GM31833 LD11990 LD15880 LD17317 LD20840 LD29110 LD30073 LD31685 LD42246 LD47845 LP01258 RE05606 RE06051 RE06316 RE10074 RE13130 RE18111 RE18177 RE18322 RE18538 RE18562 RE21793 RE23247 RE24826 RE25474 RE25635 RE26192 RE26354 RE28977 RE29140 RE30218 RE32115 RE33633 RE35080 RE35421 RE38766 RE42830 RE43852 RE45328 RE45479 RE45628 RE48305 RE50973 RE51015 RE53109 RE53111 RE61310 RE61540 RE61666 RE63318 RE63689 RE70935 RE71256 RE71313 RE71644 RE73201 RH07461 RH14057 RH72954 SD11584 SD12689 SD12789 SD12850 SD13714 SD15915 SD16946 SD18009 SD26202
Other clones	18820 33342 43158 47201 52180 53329 53432 57613 103455 107188 108722 117393 118160 145353 149715 165950 214375.74 281929 527273 557841 AT01142 CK01.5C.F8 CK01.71A.A10 CK01.72C.G7 CK01.144B.C4 Dmel_neb_010658_0634_0450 Dmel_neb_012684_0695_3432 EK056533 EK057428 EK133426 EK143913 EK157415 EK162951 EK166337 EK166920 EK170835 EK171010 EK178841 EK180636 EK193908 EK194208 EK209333 EK222104 EK235140 EK236444 EK243019 EK252243 EK255429 EK264961 EK307436 EN06559 EN07103 EN07617 EN12004 EN12515 EP02059 EP06756 EP09547 FGC028B12 FGM102E01 FGM224C12 RP004154622 UT01714
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0259937 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37873
Antibody Information
	polyclonal (Phillips et al., 1998, Riccardo et al., 2007)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Nop60B CG3333 (Wang, 1999.11)
Source for database merge of	Source for merge of: l(2)k05318 Nop60B (Phillips et al., 1998) Source for merge of: Nop60B Uhg6 (FlyBase, 1996-)
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene results in a change in cell proliferation. (Guertin et al., 2006) One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders. (Inlow and Restifo, 2004) Nop60B hosts the snoRNA:H1 gene in its fourth intron. Overall orientation not stated: Nop60B+ snoRNA:H1+ Nop60B+ (Giordano et al., 1999) Nop60B plays a central role in ribosomal RNA processing and pseudouridylation. (Giordano et al., 1999) The 3' exons of Nop60B are non-coding and correspond to Uhg6, a snoRNA host gene. (FlyBase, 1996-)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080381 NM_001014547 NM_001169815 NM_001169816 NM_001169817 NM_001169818 RefSeq (Proteins) • NP_525120 NP_001014547 NP_001163286 NP_001163287 NP_001163288 NP_001163289 DDBJ / EMBL / GenBank • AA536558 AAC97117 AAD16092 AAD19897 AAF47178 AAF47178.1 AAL90146 AAX52682 ABH08965 ABI17547 ABI17548 ACZ94558 ACZ94559 ACZ94560 ACZ94561 AF017230 AF089837 AF097634 AQ025756 AY089408 AY805216 BF487909 CZ483791 DQ841550 DQ857345 DQ857346 Entrez Gene - A searchable database of RefSeq genes. • 37873 UniProtKB/Swiss-Prot • O44081 UniProtKB/TrEMBL • E1JGV6 Q95S65
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • PUA-like domain (IPR015947) Pseudouridine synthase/archaeosine transglycosylase (IPR002478) Pseudouridine synthase II (IPR002501) Pseudouridine synthase-related (IPR004802) Dyskerin-like (IPR012960) Pseudouridine synthase, catalytic domain (IPR020103)
Linkouts
	BioGRID - A database of protein and genetic interactions • 63449 DroID - A comprehensive database of gene and protein interactions. • FBgn0259937 DRSC - Results from RNAi screens. • FBgn0259937 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259937 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0259937 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37873 InParanoid A subset of ortholog calls from InParanoid. • AAEL003514-PA Aedes aegypti (mosquito) AGAP004739-PA Anopheles gambiae (mosquito) XP_397244.3 Apis mellifera (honey bee) XP_001951759.1 Acyrthosiphon pisum (pea aphid) At3g57150.1 Arabidopsis thaliana (wall cress) 16206 Batrachochytrium dendrobatidis (chytrid fungus) 71433 Branchiostoma floridae (lancelet) BGIBMGA003833-PA Bombyx mori (silk worm) ENSBTAP00000017339 Bos taurus (bovine) CAL0001653 Candida albicans (a form of yeast) CN05538 Caenorhabditis brenneri (small nematode) CBP04263 Caenorhabditis briggsae (nematode) CE16195 Caenorhabditis elegans (worm) ENSCAFP00000029020 Canis familiaris (dog) CAGL0H03685g Candida glabrata (haploid yeast) Chro.30435 Cryptosporidium hominis (obligate parasite) ENSCINP00000009502 Ciona intestinalis (sea squirt) JA09222 Caenorhabditis japonica (nematode) CMM044C Cyanidioschyzon merolae (red alga) cn04348 Cryptococcus neoformans (yeast-like fungus) cgd3_3850 Cryptosporidium parvum (protozoan parasite) CPIJ000795 Culex pipens (mosquito) CPIJ006466 Culex pipens (mosquito) ENSCPOP00000007923 Cavia porcellus (guinea pig) 99415 Chlamidomonas reinhardtii (green alga) RP26239 Caenorhabditis remanei (nematode) ENSCSAVP00000017089 Ciona savignyi (sedentary tunicate) 226101 Capitella spl (polychaete worm) DDB0233679 Dictyostelium discoideum (amoeba) DEHA2G11748g Debaryomyces Hansenii (yeast) 228342 Daphnia pulex (daphnia) ENSDARP00000007628 Danio rerio (zebra fish) ENSECAP00000021150 Equus caballus (horse) XP_649989 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000005785 Gymnopilus aculeatus (mushroom) ENSGALP00000008091 Gallus gallus (chicken) GL50803_16311 Giardia lamblia (flagellated protozoan) 113964 Hypsipyla robusta (cedar shoot borer) ENSP00000377168 Homo sapiens (human) ISCW017820-PA Ixodes scapularis (deer tick) KLLA0D04796g Kluyveromyces lactis (yeast) 139266 Lottia gigantea (owl limpet) LmjF21.1760 Leishmania major (virus) 17370 Monocosta brevicollis (choanoflagellate) ENSMODP00000011539 Monodelphis domestica (gray opossum) ENSMMUP00000007617 Macaca mulatta (rhesus monkey) ENSMUSP00000033776 Mus musculus (house mouse) 92827 Nematostella vectensis (starlet anemone) ENSOANP00000013881 Ornithorynchus anatinus (platypus) ENSORLP00000023417 Oryzias latipes (japanese killifish) LOC_Os03g25450.1 Oryza sativa (asian rice) 30756 Ostreococcus tauri (green alga) PF14_0174 Plasmodium falciparum (protozoal parasite) PHUM010025-PA Pediculus humanus (human body louse) PP18907 Pristionchus pacificus (nematode) 195956 Physcomitrella patens (moss) ENSPPYP00000023387 Pongo pygmaeus (orangutan) 71515 Phytophthora ramorum (sudden oak death pathogen) 156946 Phytophthora sojae (root rot pathogen) 417935 Populus trichocarpa (black cottonwood) ENSPTRP00000059699 Pan troglodytes (chimpanzee) PVX_085575 Plasmodium vivax (protozoal parasite) 4876587 Sorghum bicolor (sorghum) YLR175W Saccharomyces cerevisiae (budding yeast) Smp_068920.2 Schistosoma mansoni (trematode parasite) SPAC29A4.04c Schizosaccharomyces pombe (fission yeast) XP_789483.2 Strongylocentrotus purpuratus (purple sea urchin) 19124 Trichoplax adhaerens (metazoa) TA13560 Theileria annulata (apicomplexan parasite) XP_967291.1 Tribolium castaneum (red flour beetle) Tc00.1047053504069.90 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511145.70 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000005134 Tetraodon nigroviridis (green spotted pufferfish) TP02_0508 Theileria parva (parasitic protozoan) 508 Thalassiosira pseudonana (marine diatom) ENSTRUP00000010488 Takifugu rubripes (pufferfish Takifugu) 7.m00302 Tetrahymena thermophila (ciliate protozoa) 94275.m00107 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000051364 Xenopus tropicalis (frog) YALI0E13486g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/nucpr60b1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37873 modMine - Data generated by the modENCODE project. • FBgn0259937 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16557 NV51120 LH24383 ISCW017820 FBgn0231995 FBgn0208698 FBgn0183578 FBgn0173221 JGI_V11_228342 FBgn0245486 FBgn0157577 FBgn0144040 FBgn0128436 FBgn0115107 FBgn0088421 CPIJ006466 CPIJ000795 BGIBMGA003833 ACYPI008354 ACYPI001882 GB11348 AGAP004739 AAEL003514 PHUM464860 GLEAN_10569
Synonyms & Secondary IDs ( 16 )
Reported As
Symbol Synonym	CG333 (Accardo et al., 2004) CG3333 (Deloger et al., 2009, Huang et al., 2005, Kroiss et al., 2009, Keleman et al., 2009.8.5) dUhg6 (Huang et al., 2005) FBgn0023184 (Raychaudhuri et al., 2003) l(2)k05318   mfl (Riccardo et al., 2003, Giordano et al., 2002, Giordano, 1998.10.6, Giordano et al., 1999, Tortoriello et al., 2009, Riccardo et al., 2007, Tortoriello et al., 2010) MFL/Nop60B (Accardo et al., 2004) Nop60 (Grewal et al., 2007) Nop60b (Deloger et al., 2009, Riccardo et al., 2007) Nop60B (FlyBase, 1996-, Guertin et al., 2006, Secombe et al., 2007, Orian et al., 2007, Pierce et al., 2008, Demontis and Perrimon, 2009, Teleman et al., 2008, Kroiss et al., 2009, Rhodes et al., 2010, Marinho et al., 2011, Neumüller et al., 2011) nop60B (Kauffman et al., 2003) Uhg6
Name Synonym	dUhg-like 6 (Qu and Huang, 2004.11.1) minifly (Jorgensen and Tyers, 2004, Tycowski and Steitz, 2001, Giordano et al., 1999, Riccardo et al., 2007, Tortoriello et al., 2010) Minifly (Kroiss et al., 2009) Nucleolar protein at 60B (FlyBase, 1996-) Uhg6
Secondary FlyBase IDs
	FBgn0022178 FBgn0023184 FBgn0083122
References ( 59 )
Generate a list of	All references relating to this gene ( 59 )
List References by type	Research paper  ( 29 ) Supplementary material  ( 5 ) Review  ( 3 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 3 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 3 ) Curated genome annotation  ( 1 ) Computer file  ( 4 ) Protein sequence record  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 5 )
	Marinho et al., 2011, Development 138(2): 349--357 The Drosophila Nol12 homologue viriato is a dMyc target that regulates nucleolar architecture and is required for dMyc-stimulated cell growth. [FBrf0212565] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Rhodes et al., 2010, Dev. Biol. 344(2): 637--649 Positive regulation of c-Myc by cohesin is direct, and evolutionarily conserved. [FBrf0211404] Tortoriello et al., 2010, FEBS J. 277(15): 3249--3263 Linking pseudouridine synthases to growth, development and cell competition. [FBrf0211423] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...