FlyBase Gene Report: Dmel\vlc

General Information

Symbol

Dmel\vlc

Species

D. melanogaster

Name

vulcan

Annotation Symbol

CG8390

Feature Type

protein_coding_gene

FlyBase ID

FBgn0259978

Gene Model Status

Current

Stock Availability

9 publicly available

Gene Snapshot

vulcan (vlc) is induced above a basal level by 20-hydroxyecdysone in late third instar larvae. Its mutants die primarily as pharate adults with defects in ecdysone-induced leg morphogenesis. [Date last reviewed: 2019-03-21]

Other Summaries

Alliance
Auto summary
Interactive Fly

Also Known As

l(2)07022, anon-41Fa

Key Links

Genomic Location

Cytogenetic map

41F9-41F11

Sequence location

2R:5,702,112..5,705,439 [+]

Recombination map

2-55

RefSeq locus

NT_033778 REGION:5702112..5705439

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (4 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables molecular adaptor activity

inferred from biological aspect of ancestor with PANTHER:PTN000270003

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in regulation of postsynaptic neurotransmitter receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN000270003

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in glutamatergic synapse

inferred from biological aspect of ancestor with PANTHER:PTN000270003

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in postsynaptic specialization

inferred from biological aspect of ancestor with PANTHER:PTN000270003

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

SAPAP family

Summaries

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\vlc for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene

gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

vlc-RA

FBtr0086039

NM_080129

2531

605

vlc-RB

FBtr0086040

NM_165444

2388

583

vlc-RC

FBtr0086041

NM_165442

2454

605

vlc-RE

FBtr0300502

NM_001169585

2626

605

vlc-RF

FBtr0300503

NM_001169586

2541

605

vlc-RG

FBtr0307530

NM_001259213

2487

605

vlc-RH

FBtr0307531

NM_001259214

2369

605

vlc-RI

FBtr0307532

NM_165443

2425

605

Additional Transcript Data and Comments

Reported size (kB)

3.0, 2.7 (northern blot)

(Gates and Thummel, 2000, Spradling et al., 1999)

2.4 (northern blot)

(Bourgouin et al., 1992)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

vlc-PA

FBpp0085375

66.2

605

6.58

NP_524868

AAF57316

vlc-PB

FBpp0085376

63.6

583

6.12

NP_724427

AAM68356

vlc-PC

FBpp0085377

66.2

605

6.58

NP_724425

AAF57315

vlc-PE

FBpp0289729

66.2

605

6.58

NP_001163056

ACZ94336

vlc-PF

FBpp0289730

66.2

605

6.58

NP_001163057

ACZ94337

vlc-PG

FBpp0300185

66.2

605

6.58

NP_001246142

AFH07897

vlc-PH

FBpp0300186

66.2

605

6.58

NP_001246143

AFH07898

vlc-PI

FBpp0300187

66.2

605

6.58

NP_724426

AAM68355

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

605 aa isoforms: vlc-PA, vlc-PC, vlc-PE, vlc-PF, vlc-PG, vlc-PH, vlc-PI

Additional Polypeptide Data and Comments

Reported size (kDa)

605 (aa)

(Gates and Thummel, 2000, Spradling et al., 1999)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

SAPAP family

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\vlc using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

vlc_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 9

cephalic furrow

Comment: reference states 3.5 hr AEL

(Bourgouin et al., 1992)

ventral furrow

Comment: reference states 3.5 hr AEL

(Bourgouin et al., 1992)

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | faint | ubiquitous

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage & pupal stage

(Gates and Thummel, 2000, Spradling et al., 1999)

Additional Descriptive Data

The 2.7kb and 3.0kb vlc transcripts are detected in third instar larvae. Levels increase in late third instar larvae. Both transcripts are present in third instar larvae but the 3.0kb transcript predominates at puparium formation. vlc transcripts are induced by ecdysone.

(Gates and Thummel, 2000)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\vlc in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\vlc

View exonic expression by tissue for Dmel\vlc

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0259978

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0259978

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8390

Flygut - An atlas of the Drosophila adult midgut

FBgn0259978

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 10 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of vlc

Transgenic constructs containing regulatory region of vlc

Deletions and Duplications ( 38 )

Disrupted in

Df(2R)ap^DG16

(Bieli et al., 2015)

Df(2R)BSC696

(Christensen et al., 2008.12.28)

Df(2R)M41A4

(Gates and Thummel, 2000, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(2R)M41A8

(Myster et al., 2004)

Df(2R)nap1

(Gambetta and Müller, 2009.8.18, Myster et al., 2004, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(2R)nap2

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(2R)nap4

(Gambetta and Müller, 2009.8.18)

Df(2R)nap5

(BDGP Project Members, 1994-1999)

Df(2R)nap8

(Gambetta and Müller, 2009.8.18)

Df(2R)nap11

(Gambetta and Müller, 2009.8.18)

Df(2R)nap13

(BDGP Project Members, 1994-1999)

Df(2R)NC13

(Myster et al., 2004, Myster and Peifer, 2003.9.11)

Df(2R)NC73

(Myster et al., 2004, Myster and Peifer, 2003.9.11)

Df(2R)NC191

(Myster et al., 2004)

Df(2R)NC228

(Myster et al., 2004, Myster and Peifer, 2003.9.11)

Not disrupted in

Df(2L)TW161

(BDGP Project Members, 1994-1999)

Df(2R)244

(Myster et al., 2004)

Df(2R)247

(Myster et al., 2004)

Df(2R)ap^12.1

(Bieli et al., 2015)

Df(2R)ap^12.1-Mcp

(Bieli et al., 2015)

Df(2R)cn88b

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(2R)Dark2

(Myster et al., 2004)

Df(2R)M41A2

(Myster et al., 2004)

Df(2R)M41A8

(Gambetta and Müller, 2009.8.18)

Df(2R)M41A10

(Gambetta and Müller, 2009.8.18, Myster et al., 2004, Corradini et al., 2003)

Df(2R)NC32

(Gambetta and Müller, 2009.8.18, Myster et al., 2004)

Df(2R)NC50

(Myster et al., 2004)

Df(2R)NC68

(Myster et al., 2004)

Df(2R)NC98

(Myster et al., 2004)

Df(2R)NC125

(Myster et al., 2004)

Df(2R)NC167

(Myster et al., 2004)

Df(2R)NC168

(Myster et al., 2004)

Df(2R)NC195

(Myster et al., 2004)

Df(2R)NC202

(Myster et al., 2004)

Df(2R)NC207

(Myster et al., 2004)

Df(2R)NC218

(Myster et al., 2004)

Df(2R)NC219

(Myster et al., 2004)

Df(2R)NC1198

(Myster et al., 2004)

Df(2R)Nipped-D

(Myster et al., 2004)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

vlc^GD16319

viable, with Scer\GAL4^pnr-MD237

vlc^GD16319

viable, with Scer\GAL4^tin.CΔ4

vlc^GD16319

Other Phenotypes

Allele

visible | pharate adult stage | recessive

vlc⁰⁷⁰²²

Phenotype manifest in

Allele

leg

vlc⁰⁷⁰²²

metathoracic tarsal segment 2

vlc⁰⁷⁰²²

metathoracic tibia

vlc⁰⁷⁰²²

wing

vlc⁰⁷⁰²²

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (7)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\DLGAP1

7 of 15

Yes

Hsap\DLGAP3

7 of 15

Yes

Hsap\DLGAP4

7 of 15

Yes

Hsap\DLGAP2

6 of 15

Yes

Hsap\DLGAP5

4 of 15

Hsap\IL1RAPL1

1 of 15

Yes

Hsap\IL1RAPL2

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (7)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Dlgap1

7 of 15

Yes

Mmus\Dlgap3

7 of 15

Yes

Mmus\Dlgap4

7 of 15

Yes

Mmus\Dlgap2

6 of 15

Yes

Mmus\Dlgap5

3 of 15

Mmus\Il1rapl1

1 of 15

Yes

Mmus\Il1rapl2

1 of 15

Yes

Rattus norvegicus (Norway rat) (6)

Rnor\Dlgap1

6 of 13

Yes

Rnor\Dlgap3

6 of 13

Yes

Rnor\Dlgap4

6 of 13

Yes

Rnor\Dlgap2

5 of 13

Yes

Rnor\Dlgap5

4 of 13

Rnor\Il1rapl1

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (5)

Xtro\dlgap3

6 of 12

Yes

Xtro\dlgap1

4 of 12

Yes

Xtro\dlgap2

4 of 12

Yes

Xtro\dlgap4

4 of 12

Yes

Xtro\dlgap5

3 of 12

Danio rerio (Zebrafish) (13)

Drer\dlgap4b

6 of 15

Yes

Drer\dlgap1a

5 of 15

Yes

Drer\dlgap1b

5 of 15

Yes

Drer\dlgap3

5 of 15

Yes

Drer\dlgap2a

4 of 15

Yes

Drer\dlgap4a

4 of 15

Yes

Drer\dlgap5

3 of 15

Drer\LOC796210

2 of 15

Yes

Drer\dlgap2b

1 of 15

Yes

Drer\il1rapl1a

1 of 15

Yes

Drer\il1rapl1b

1 of 15

Yes

Drer\il1rapl2

1 of 15

Yes

Drer\LOC110437706

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\W03A5.6

4 of 15

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190A83 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA21040

Drosophila persimilis

Dper\GL17527

Drosophila willistoni

Dwil\vlc

Drosophila virilis

Dvir\vlc

Drosophila mojavensis

Dmoj\GI19933

Drosophila grimshawi

Dgri\GH21456

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091506T1 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17022692

Glossina morsitans

Tsetse fly

Gmor\GMOY010864

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_08676

Mayetiola destructor

Hessian fly

Mdes\Mdes008731

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL011250

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL008686

Anopheles darlingi

American malaria mosquito

Adar\ADAC008288

Anopheles gambiae

Malaria mosquito

Agam\AGAP008983

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ018356

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ010102

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W06Z7 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA009661

Danaus plexippus

Monarch butterfly

Dple\DPOGS213854-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL010304

Apis florea

Little honeybee

Aflo\2205506212

Apis mellifera

Western honey bee

Amel\GB50675

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP23456

Bombus terrestris

Buff-tailed bumblebee

Bter\15210199

Linepithema humile

Argentine ant

Lhum\LH12915

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0017a7

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG003336

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_05383

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_05382

Tribolium castaneum

Red flour beetle

Tcas\TC009315

Pediculus humanus

Human body louse

Phum\PHUM034510

Rhodnius prolixus

Kissing bug

Rpro\RPRC013268

Rhodnius prolixus

Kissing bug

Rpro\RPRC013277

Rhodnius prolixus

Kissing bug

Rpro\RPRC013789

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI000905

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_07551

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X06UI )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR013794

Ixodes scapularis

Black-legged tick

Isca\ISCW016197

Stegodyphus mimosarum

African social velvet spider

Smim\KFM71205.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur27g01600

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_301948

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0G4S )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hypp_616

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (1)

Gene Symbol

Score

Source

Alignment

2 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

DLGAP1; DLG associated protein 1

7 of 15

605445

DLGAP3; DLG associated protein 3

7 of 15

611413

DLGAP4; DLG associated protein 4

7 of 15

616191

DLGAP2; DLG associated protein 2

6 of 15

605438

DLGAP5; DLG associated protein 5

4 of 15

617859

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

vlc - Dsor1

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

vlc - RasGAP1

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

vlc - dos

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

70090

DroID - A comprehensive database of gene and protein interactions.

FBgn0259978

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

46078

MIST (protein-protein) - An integrated Molecular Interaction Database

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-55

Cytogenetic map

41F9-41F11

Sequence location

2R:5,702,112..5,705,439 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

41F9-41F11

Left limit from molecular mapping relative to ap (FBrf0057363) Right limit from molecular mapping relative to anon-41Fb (FBrf0057363)

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

vlc^k01109 insertion is located at the base of h46.

(Corradini et al., 2003)

h46-h46

(determined by in situ hybridisation)

(Corradini et al., 2003)

41F8-41F9

(determined by in situ hybridisation)

(Spradling et al., 1999)

41F8-41F9

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-55

(FlyBase, 2016)

2-55.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Bloomington

40925

y¹ v¹; P{TRiP.HMS02173}attP40

12331

cn¹ P{PZ}vlc⁰⁷⁰²²/CyO; ry⁵⁰⁶

10366

y¹ w^67c23; P{lacW}vlc^k01109/CyO

19821

y¹ w^67c23; P{EPgy2}vlc^EY01995/CyO

79360

y¹ w^*; TI{CRIMIC.TG4.1}vlc^{CR00923-TG4.1}/SM6a

Kyoto

125429

w¹¹¹⁸; P{RS5}vlc^5-HA-1849

102190

y¹ w^67c23 ; P{lacW}vlc^k01109 / CyO

VDRC

v46230

w¹¹¹⁸; P{GD16319}v46230

v46229

w¹¹¹⁸; P{GD16319}v46229/TM3

Genomic Clones (20)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (97)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0259978

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0259978

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

46078

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: vulcan CG8390

(FlyBase, 1996-)

Source for merge of: vlc anon-41Fa

(FlyBase, 1996-)

Source for merge of: vlc anon-WO0118547.98

(FlyBase, 1996-)

Additional comments

Source for merge of vulcan CG8390 was sequence comparison ( date:000721 ).

(FlyBase, 1996-)

Source for merge of vlc anon-WO0118547.98 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Other Comments

Area matching Drosophila EST AA263700. This EST overlaps EST AA978721.

(Davies, 2001.3.15)

Transcript mapped to position -0.5 to -2.8 in the ap region, less than 1kb from the 3' end of ap.

(Bourgouin et al., 1992)

Transcription unit neighbouring (3' of) ap transcription unit.

(Bourgouin et al., 1992)

Origin and Etymology

Discoverer

Etymology

The gene is named "vulcan" (after the malformed leg phenotype of mutants) after the Roman god who broke both his legs as he fell to earth upon being thrown from heaven by Jupiter.

(Gates and Thummel, 2000)

Identification

External Crossreferences and Linkouts ( 62 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

46078

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0259978

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0259978

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

vlc_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8390

Flygut - An atlas of the Drosophila adult midgut

FBgn0259978

FlyMine - An integrated database for Drosophila genomics

FBgn0259978

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

46078

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC009315

InterPro - A database of protein families, domains and functional sites

SAPAP family

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG8390

modMine - A data warehouse for the modENCODE project

FBgn0259978

Linkouts

BioGRID - A database of protein and genetic interactions.

70090

DroID - A comprehensive database of gene and protein interactions.

FBgn0259978

DRSC - Results frm RNAi screens

FBgn0259978

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0259978

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

46078

MIST (protein-protein) - An integrated Molecular Interaction Database

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

CG8390

(Kolkhof et al., 2017, Hosono et al., 2015, McEachern et al., 2014, Ni et al., 2010.12.1, Seinen et al., 2010)

(Bourgouin et al., 1992)

anon-41Fa

anon-WO0118547.98

l(2)07022

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

vlc

(Gene Disruption Project members, 2018-, Ashwal-Fluss et al., 2014, Sopko et al., 2014, Kwon et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Friedman et al., 2011, Usov et al., 2011, Christensen et al., 2008.12.28, Bartolome and Charlesworth, 2006)

Name Synonyms

Vulcan

(McEachern et al., 2014)

anon-41Fa

transcription unit X

(Bourgouin et al., 1992)

vulcan

(Bieli et al., 2015, Zhan et al., 2014, Gambetta and Müller, 2009.8.18, Dimitri et al., 2003, Gates and Thummel, 2000)

Secondary FlyBase IDs

FBgn0010633
FBgn0033036
FBgn0061521
FBgn0014098

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (59)

The following external sites may use different assemblies or annotations than FlyBase.

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