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Gene Dmel\vlc

General Information
Symbol	Dmel\vlc	Species	D. melanogaster
Name	vulcan	Annotation symbol	CG8390
Feature type	protein_coding_gene	FlyBase ID	FBgn0259978
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	l(2)07022
Genomic Location
Chromosome (arm)	2R	Recombination map	2-
Cytogenetic map	41F9-41F8	Sequence location	2R:1,589,605..1,592,944 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene vulcan is referred to in FlyBase by the symbol Dmel\vlc (CG8390, FBgn0259978). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. It is reported to be involved in the biological process: imaginal disc-derived leg morphogenesis. 11 alleles are reported. The phenotypes of these alleles are annotated with: metathoracic tarsal segment 2; leg; wing; metathoracic tibia. It has 8 annotated transcripts and 8 annotated polypeptides. Protein features are: Guanylate-kinase-associated protein. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult ovary, adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1639759_s_at completely aligns to an exonic region common to each of the 6 FlyBase-annotated transcript isoforms of vlc. Gene sequence location is 2R:1589605..1592944.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features HFA04922 BKN21881
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 41F9-41F8   Left limit from molecular mapping relative to ap (FBrf0057363) Right limit from molecular mapping relative to anon-41Fb (FBrf0057363); Limits computationally determined from genome sequence between P{PZ}vlc07022&P{lacW}l(2)09851k08138 and P{PZ}l(2)0985109851&P{lacW}Src42Ak10108
Experimentally Determined Cytological Location
Cytogenetic map Notes References h46-h46   vlck01109 insertion is located at the base of h46. (determined by in situ hybridisation)   (Corradini et al., 2003) 41F8-41F9   (determined by in situ hybridisation)   (Spradling et al., 1999) 41F8-41F9     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	2-
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\vlc for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) vlc-RA FBtr0086039  NM_080129   2543   605 vlc-RB FBtr0086040  NM_165444   2400   583 vlc-RC FBtr0086041  NM_165442   2466   605 vlc-RE FBtr0300502  NM_001169585   2638   605 vlc-RF FBtr0300503  NM_001169586   2541   605 vlc-RG FBtr0307530     2487   605 vlc-RH FBtr0307531     2381   605 vlc-RI FBtr0307532     2437   605
Additional Transcript Data & Comments
Reported size (kB)	3.0, 2.7 (northern blot) (Spradling et al., 1999, Gates and Thummel, 2000) 2.4 (northern blot) (Bourgouin et al., 1992)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein vlc-PA   FBpp0085375   66.2   605   6.58     NP_524868   AAF57316 vlc-PB   FBpp0085376   63.6   583   6.12     NP_724427   AAM68356 vlc-PC   FBpp0085377   66.2   605   6.58     NP_724425   AAF57315 vlc-PE   FBpp0289729   66.2   605   6.58     NP_001163056   ACZ94336 vlc-PF   FBpp0289730   66.2   605   6.58     NP_001163057   ACZ94337 vlc-PG   FBpp0300185   66.2   605   6.58       vlc-PH   FBpp0300186   66.2   605   6.58       vlc-PI   FBpp0300187   66.2   605   6.58
Additional Polypeptide Data & Comments
Reported size (kDa)	605 (aa) (Spradling et al., 1999, Gates and Thummel, 2000)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Guanylate-kinase-associated protein (IPR005026)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201629   AA202598   AA202606   AA202947   AA263700   AA392733   AA538803   AA539190   AA540808   AA816472   AA816596   AA950426   AA978721   AA990817   AE013599 AAF57315   AE013599 AAF57316   AE013599 AAM68356   AE013599 ACZ94336   AE013599 ACZ94337   AF275628 AAF78761   AI061716   AI109415   AI260197   AI455730   AI456308   AI511803   AI512182   AI512790   AI513422   AI515865   AW943748   AX093974   AY061484 AAL29032   BF486257   BF503669   BF505875   BG634713   BG636080   BG636081   BG637731   BG638001   BI163297   BI164571   BI173872   BI212236   BI215088   BI215109   BI227799   BI228142   BI228548   BI229890   BI230458   BI234695   BI234837   BI235892   BI357333   BI364482   BI365061   BI367193   BI372451   BI375539   BI482613   BI484042   BI486199   BI580168   BI580826   BI581957   BI618280   BI632428   BT100113   CL705769   CO185504   CO186928   CO265721   CO279092   CO303060   CO303071   CO305934   CO311164   CO313449   CO317910   CO318054   CO323320   CO337109   CO341114   CZ472308   CZ472310   CZ477939   EC052711   EC053197   EC054197   EC054459   EC055468   EC055496   EC064350   EC065606   EC068497   EC084309   EC088116   EC088487   EC202194   EC206358   EC206359   EC211947   EC225867   EC233428   EC244530   EC247351   EC249324   EC266953   EV576244   EV584989   EV589113   G01159
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	A1Z6H4 A1Z6H3 Q7K1T1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 9   cephalic furrow   (Bourgouin et al., 1992) Comment:reference states 3.5 hr AEL ventral furrow   (Bourgouin et al., 1992) Comment:reference states 3.5 hr AEL northern blot Stage Tissue/Position (including subcellular localization) Reference larval stage & pupal stage     (Spradling et al., 1999, Gates and Thummel, 2000)
Additional Descriptive Data
	The 2.7kb and 3.0kb vlc transcripts are detected in third instar larvae. Levels increase in late third instar larvae. Both transcripts are present in third instar larvae but the 3.0kb transcript predominates at puparium formation. vlc transcripts are induced by ecdysone. (Gates and Thummel, 2000)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0259978    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0259978 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0259978 expression level Developmental Stage   Expression Level embryo 00-02hr    6460 embryo 02-04hr    6386 embryo 04-06hr    4002 embryo 06-08hr    3803 embryo 08-10hr    4162 embryo 10-12hr    3189 embryo 12-14hr    3247 embryo 14-16hr    1797 embryo 16-18hr    1906 embryo 18-20hr    930 embryo 20-22hr    2732 embryo 22-24hr    2778 larva L1    887 larva L2    869 larva L3 12hr old    694 larva L3 puffstage 1-2    984 larva L3 puffstage 3-6    1570 larva L3 puffstage 7-9    2084 white prepupae new    1998 white prepupae 12hr    2614 white prepupae 24hr    3357 pupae 2d postWPP    3199 pupae 3d postWPP    2195 pupae 4d postWPP    1211 adult male 01day    2236 adult male 05day    2557 adult male 30day    1981 adult female 01day    1593 adult female 05day    4117 adult female 30day    3627 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6460) embryo 02-04hr  (6386) embryo 04-06hr  (4002) embryo 06-08hr  (3803) embryo 08-10hr  (4162) embryo 10-12hr  (3189) embryo 12-14hr  (3247) embryo 14-16hr  (1797) embryo 16-18hr  (1906) embryo 18-20hr  (930) embryo 20-22hr  (2732) embryo 22-24hr  (2778) larva L1  (887) larva L2  (869) larva L3 12hr old  (694) larva L3 puffstage 1-2  (984) larva L3 puffstage 3-6  (1570) larva L3 puffstage 7-9  (2084) white prepupae new  (1998) white prepupae 12hr  (2614) white prepupae 24hr  (3357) pupae 2d postWPP  (3199) pupae 3d postWPP  (2195) pupae 4d postWPP  (1211) adult male 01day  (2236) adult male 05day  (2557) adult male 30day  (1981) adult female 01day  (1593) adult female 05day  (4117) adult female 30day  (3627) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6460) embryo 02-04hr  (6386) embryo 04-06hr  (4002) embryo 06-08hr  (3803) embryo 08-10hr  (4162) embryo 10-12hr  (3189) embryo 12-14hr  (3247) embryo 14-16hr  (1797) embryo 16-18hr  (1906) embryo 18-20hr    930 embryo 20-22hr  (2732) embryo 22-24hr  (2778) larva L1    887 larva L2    869 larva L3 12hr old    694 larva L3 puffstage 1-2    984 larva L3 puffstage 3-6  (1570) larva L3 puffstage 7-9  (2084) white prepupae new  (1998) white prepupae 12hr  (2614) white prepupae 24hr  (3357) pupae 2d postWPP  (3199) pupae 3d postWPP  (2195) pupae 4d postWPP    1211 adult male 01day  (2236) adult male 05day  (2557) adult male 30day  (1981) adult female 01day  (1593) adult female 05day  (4117) adult female 30day  (3627) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6460 embryo 02-04hr    6386 embryo 04-06hr    4002 embryo 06-08hr    3803 embryo 08-10hr    4162 embryo 10-12hr    3189 embryo 12-14hr    3247 embryo 14-16hr    1797 embryo 16-18hr    1906 embryo 18-20hr    930 embryo 20-22hr    2732 embryo 22-24hr    2778 larva L1    887 larva L2    869 larva L3 12hr old    694 larva L3 puffstage 1-2    984 larva L3 puffstage 3-6    1570 larva L3 puffstage 7-9    2084 white prepupae new    1998 white prepupae 12hr    2614 white prepupae 24hr    3357 pupae 2d postWPP    3199 pupae 3d postWPP    2195 pupae 4d postWPP    1211 adult male 01day    2236 adult male 05day    2557 adult male 30day    1981 adult female 01day    1593 adult female 05day    4117 adult female 30day    3627 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6460 embryo 02-04hr    6386 embryo 04-06hr    4002 embryo 06-08hr    3803 embryo 08-10hr    4162 embryo 10-12hr    3189 embryo 12-14hr    3247 embryo 14-16hr    1797 embryo 16-18hr    1906 embryo 18-20hr    930 embryo 20-22hr    2732 embryo 22-24hr    2778 larva L1    887 larva L2    869 larva L3 12hr old    694 larva L3 puffstage 1-2    984 larva L3 puffstage 3-6    1570 larva L3 puffstage 7-9    2084 white prepupae new    1998 white prepupae 12hr    2614 white prepupae 24hr    3357 pupae 2d postWPP    3199 pupae 3d postWPP    2195 pupae 4d postWPP    1211 adult male 01day    2236 adult male 05day    2557 adult male 30day    1981 adult female 01day    1593 adult female 05day    4117 adult female 30day    3627 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0259978 expression level Developmental Stage   Expression Level embryo 00-02hr    6460 embryo 02-04hr    6386 embryo 04-06hr    4002 embryo 06-08hr    3803 embryo 08-10hr    4162 embryo 10-12hr    3189 embryo 12-14hr    3247 embryo 14-16hr    1797 embryo 16-18hr    1906 embryo 18-20hr    930 embryo 20-22hr    2732 embryo 22-24hr    2778 larva L1    887 larva L2    869 larva L3 12hr old    694 larva L3 puffstage 1-2    984 larva L3 puffstage 3-6    1570 larva L3 puffstage 7-9    2084 white prepupae new    1998 white prepupae 12hr    2614 white prepupae 24hr    3357 pupae 2d postWPP    3199 pupae 3d postWPP    2195 pupae 4d postWPP    1211 adult male 01day    2236 adult male 05day    2557 adult male 30day    1981 adult female 01day    1593 adult female 05day    4117 adult female 30day    3627 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6460) embryo 02-04hr  (6386) embryo 04-06hr  (4002) embryo 06-08hr  (3803) embryo 08-10hr  (4162) embryo 10-12hr  (3189) embryo 12-14hr  (3247) embryo 14-16hr  (1797) embryo 16-18hr  (1906) embryo 18-20hr  (930) embryo 20-22hr  (2732) embryo 22-24hr  (2778) larva L1  (887) larva L2  (869) larva L3 12hr old  (694) larva L3 puffstage 1-2  (984) larva L3 puffstage 3-6  (1570) larva L3 puffstage 7-9  (2084) white prepupae new  (1998) white prepupae 12hr  (2614) white prepupae 24hr  (3357) pupae 2d postWPP  (3199) pupae 3d postWPP  (2195) pupae 4d postWPP  (1211) adult male 01day  (2236) adult male 05day  (2557) adult male 30day  (1981) adult female 01day  (1593) adult female 05day  (4117) adult female 30day  (3627) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6460) embryo 02-04hr  (6386) embryo 04-06hr  (4002) embryo 06-08hr  (3803) embryo 08-10hr  (4162) embryo 10-12hr  (3189) embryo 12-14hr  (3247) embryo 14-16hr  1797 embryo 16-18hr  1906 embryo 18-20hr    930 embryo 20-22hr  (2732) embryo 22-24hr  (2778) larva L1    887 larva L2    869 larva L3 12hr old    694 larva L3 puffstage 1-2    984 larva L3 puffstage 3-6  1570 larva L3 puffstage 7-9  2084 white prepupae new  1998 white prepupae 12hr  (2614) white prepupae 24hr  (3357) pupae 2d postWPP  (3199) pupae 3d postWPP  2195 pupae 4d postWPP    1211 adult male 01day  2236 adult male 05day  (2557) adult male 30day  1981 adult female 01day  1593 adult female 05day  (4117) adult female 30day  (3627) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6460 embryo 02-04hr    6386 embryo 04-06hr    4002 embryo 06-08hr    3803 embryo 08-10hr    4162 embryo 10-12hr    3189 embryo 12-14hr    3247 embryo 14-16hr    1797 embryo 16-18hr    1906 embryo 18-20hr    930 embryo 20-22hr    2732 embryo 22-24hr    2778 larva L1    887 larva L2    869 larva L3 12hr old    694 larva L3 puffstage 1-2    984 larva L3 puffstage 3-6    1570 larva L3 puffstage 7-9    2084 white prepupae new    1998 white prepupae 12hr    2614 white prepupae 24hr    3357 pupae 2d postWPP    3199 pupae 3d postWPP    2195 pupae 4d postWPP    1211 adult male 01day    2236 adult male 05day    2557 adult male 30day    1981 adult female 01day    1593 adult female 05day    4117 adult female 30day    3627 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6460 embryo 02-04hr    6386 embryo 04-06hr    4002 embryo 06-08hr    3803 embryo 08-10hr    4162 embryo 10-12hr    3189 embryo 12-14hr    3247 embryo 14-16hr    1797 embryo 16-18hr    1906 embryo 18-20hr    930 embryo 20-22hr    2732 embryo 22-24hr    2778 larva L1    887 larva L2    869 larva L3 12hr old    694 larva L3 puffstage 1-2    984 larva L3 puffstage 3-6    1570 larva L3 puffstage 7-9    2084 white prepupae new    1998 white prepupae 12hr    2614 white prepupae 24hr    3357 pupae 2d postWPP    3199 pupae 3d postWPP    2195 pupae 4d postWPP    1211 adult male 01day    2236 adult male 05day    2557 adult male 30day    1981 adult female 01day    1593 adult female 05day    4117 adult female 30day    3627 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0259978    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0259978 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult ovary, adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0259978 expression level Tissue   Expression Level Larval Central Nervous System    432.45 Larval Midgut    100.7 Larval Hindgut    276.4 Larval Malpighian Tubules    172.5 Larval Fat Body    161.4 Larval Salivary Gland    306.2 Larval Trachea    234.125 Larval Carcass    322.975 Adult Head    168.3 Adult Eye    97.325 Adult Brain    316.9 Adult Thoracic-Abdominal Ganglion    250.7 Adult Crop    206 Adult Midgut    91.7 Adult Hindgut    136.8 Adult Malpighian Tubules    93.4 Adult Fat Body    263.8 Adult Salivary Gland    140.5 Adult Heart    110.25 Adult VirginFemale Spermatheca    226.3 Adult InseminatedFemale Spermatheca    175.3 Adult Ovary    854.8 Adult Testis    816 Adult Male Accessory Gland    203.8 Adult Carcass    124.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    432.45 Larval Midgut    100.7 Larval Hindgut    276.4 Larval Malpighian Tubules    172.5 Larval Fat Body    161.4 Larval Salivary Gland    306.2 Larval Trachea    234.125 Larval Carcass    322.975 Adult Head    168.3 Adult Eye    97.325 Adult Brain    316.9 Adult Thoracic-Abdominal Ganglion    250.7 Adult Crop    206 Adult Midgut    91.7 Adult Hindgut    136.8 Adult Malpighian Tubules    93.4 Adult Fat Body    263.8 Adult Salivary Gland    140.5 Adult Heart    110.25 Adult VirginFemale Spermatheca    226.3 Adult InseminatedFemale Spermatheca    175.3 Adult Ovary  (854.8) Adult Testis  (816) Adult Male Accessory Gland    203.8 Adult Carcass    124.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    432.45 Larval Midgut    100.7 Larval Hindgut    276.4 Larval Malpighian Tubules    172.5 Larval Fat Body    161.4 Larval Salivary Gland    306.2 Larval Trachea    234.125 Larval Carcass    322.975 Adult Head    168.3 Adult Eye    97.325 Adult Brain    316.9 Adult Thoracic-Abdominal Ganglion    250.7 Adult Crop    206 Adult Midgut    91.7 Adult Hindgut    136.8 Adult Malpighian Tubules    93.4 Adult Fat Body    263.8 Adult Salivary Gland    140.5 Adult Heart    110.25 Adult VirginFemale Spermatheca    226.3 Adult InseminatedFemale Spermatheca    175.3 Adult Ovary    854.8 Adult Testis    816 Adult Male Accessory Gland    203.8 Adult Carcass    124.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    432.45 Larval Midgut    100.7 Larval Hindgut    276.4 Larval Malpighian Tubules    172.5 Larval Fat Body    161.4 Larval Salivary Gland    306.2 Larval Trachea    234.125 Larval Carcass    322.975 Adult Head    168.3 Adult Eye    97.325 Adult Brain    316.9 Adult Thoracic-Abdominal Ganglion    250.7 Adult Crop    206 Adult Midgut    91.7 Adult Hindgut    136.8 Adult Malpighian Tubules    93.4 Adult Fat Body    263.8 Adult Salivary Gland    140.5 Adult Heart    110.25 Adult VirginFemale Spermatheca    226.3 Adult InseminatedFemale Spermatheca    175.3 Adult Ovary    854.8 Adult Testis    816 Adult Male Accessory Gland    203.8 Adult Carcass    124.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0259978 expression level Tissue   Expression Level Larval Central Nervous System    432.45 Larval Midgut    100.7 Larval Hindgut    276.4 Larval Malpighian Tubules    172.5 Larval Fat Body    161.4 Larval Salivary Gland    306.2 Larval Trachea    234.125 Larval Carcass    322.975 Adult Head    168.3 Adult Eye    97.325 Adult Brain    316.9 Adult Thoracic-Abdominal Ganglion    250.7 Adult Crop    206 Adult Midgut    91.7 Adult Hindgut    136.8 Adult Malpighian Tubules    93.4 Adult Fat Body    263.8 Adult Salivary Gland    140.5 Adult Heart    110.25 Adult VirginFemale Spermatheca    226.3 Adult InseminatedFemale Spermatheca    175.3 Adult Ovary    854.8 Adult Testis    816 Adult Male Accessory Gland    203.8 Adult Carcass    124.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    432.45 Larval Midgut    100.7 Larval Hindgut    276.4 Larval Malpighian Tubules    172.5 Larval Fat Body    161.4 Larval Salivary Gland    306.2 Larval Trachea    234.125 Larval Carcass    322.975 Adult Head    168.3 Adult Eye    97.325 Adult Brain    316.9 Adult Thoracic-Abdominal Ganglion    250.7 Adult Crop    206 Adult Midgut    91.7 Adult Hindgut    136.8 Adult Malpighian Tubules    93.4 Adult Fat Body    263.8 Adult Salivary Gland    140.5 Adult Heart    110.25 Adult VirginFemale Spermatheca    226.3 Adult InseminatedFemale Spermatheca    175.3 Adult Ovary  (854.8) Adult Testis  (816) Adult Male Accessory Gland    203.8 Adult Carcass    124.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    432.45 Larval Midgut    100.7 Larval Hindgut    276.4 Larval Malpighian Tubules    172.5 Larval Fat Body    161.4 Larval Salivary Gland    306.2 Larval Trachea    234.125 Larval Carcass    322.975 Adult Head    168.3 Adult Eye    97.325 Adult Brain    316.9 Adult Thoracic-Abdominal Ganglion    250.7 Adult Crop    206 Adult Midgut    91.7 Adult Hindgut    136.8 Adult Malpighian Tubules    93.4 Adult Fat Body    263.8 Adult Salivary Gland    140.5 Adult Heart    110.25 Adult VirginFemale Spermatheca    226.3 Adult InseminatedFemale Spermatheca    175.3 Adult Ovary    854.8 Adult Testis    816 Adult Male Accessory Gland    203.8 Adult Carcass    124.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    432.45 Larval Midgut    100.7 Larval Hindgut    276.4 Larval Malpighian Tubules    172.5 Larval Fat Body    161.4 Larval Salivary Gland    306.2 Larval Trachea    234.125 Larval Carcass    322.975 Adult Head    168.3 Adult Eye    97.325 Adult Brain    316.9 Adult Thoracic-Abdominal Ganglion    250.7 Adult Crop    206 Adult Midgut    91.7 Adult Hindgut    136.8 Adult Malpighian Tubules    93.4 Adult Fat Body    263.8 Adult Salivary Gland    140.5 Adult Heart    110.25 Adult VirginFemale Spermatheca    226.3 Adult InseminatedFemale Spermatheca    175.3 Adult Ovary    854.8 Adult Testis    816 Adult Male Accessory Gland    203.8 Adult Carcass    124.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    168.3   NA  Eye    97.325   NA  Brain    316.9   432.45  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    250.7   NA  Crop    206   100.7  Midgut    91.7   276.4  Hindgut    136.8   172.5  Malpighian Tubules    93.4   161.4  Fat Body    263.8   306.2  Salivary Gland    140.5   NA  Heart    110.25   234.125  Trachea    NA   NA  VirginFemale Spermatheca    226.3   NA  InseminatedFemale Spermatheca    175.3   NA  Ovary    854.8   NA  Testis    816   NA  Male Accessory Gland    203.8   322.975  Carcass    124.7 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_01
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259978
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive vlc07022 vlck01109 viable, with Scer\GAL4pnr-MD237 vlcGD16319 Other Phenotypes Allele visible | pharate adult stage | recessive vlc07022 Phenotype manifest in Allele leg vlc07022 metathoracic tarsal segment 2 vlc07022 metathoracic tibia vlc07022 wing vlc07022
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of vlc Class Mutagen Stocks Known lesion vlck01109 P-element activity 2 -- vlc07022 P-element activity 1 Yes vlc5-HA-1849 1 -- vlcd01566 P-element activity 1 -- vlcDG19809 1 -- vlce00027 piggyBac transposase 1 -- vlcEY01995 P-element activity 1 -- vlcd01574 P-element activity 0 -- vlcunspecified 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of vlc Class Mutagen Stocks Known lesion vlcGD16319 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes vlcGD13912 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)BSC696 (Christensen et al., 2008.12.28) Df(2R)M41A4 (Spradling et al., 1999, Gates and Thummel, 2000, BDGP Project Members, 1994-1999) Df(2R)M41A8 (Myster et al., 2004, Myster et al., 2004) Df(2R)nap1 (Spradling et al., 1999, Myster et al., 2004, BDGP Project Members, 1994-1999, Gambetta and Mueller, 2009.8.18) Df(2R)nap2 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)nap4 (Gambetta and Mueller, 2009.8.18) Df(2R)nap5 (BDGP Project Members, 1994-1999) Df(2R)nap8 (Gambetta and Mueller, 2009.8.18) Df(2R)nap11 (Gambetta and Mueller, 2009.8.18) Df(2R)nap13 (BDGP Project Members, 1994-1999) Df(2R)NC13 (Myster and Peifer, 2003.9.11, Myster et al., 2004) Df(2R)NC73 (Myster and Peifer, 2003.9.11, Myster et al., 2004) Df(2R)NC191 (Myster et al., 2004) Df(2R)NC228 (Myster and Peifer, 2003.9.11, Myster et al., 2004)
Not disrupted in	Df(2L)TW161 (BDGP Project Members, 1994-1999) Df(2R)244 (Myster et al., 2004) Df(2R)247 (Myster et al., 2004) Df(2R)cn88b (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)Dark2 (Myster et al., 2004) Df(2R)M41A2 (Myster et al., 2004, Myster et al., 2004) Df(2R)M41A8 (Gambetta and Mueller, 2009.8.18) Df(2R)M41A10 (Corradini et al., 2003, Myster et al., 2004, Myster et al., 2004, Gambetta and Mueller, 2009.8.18) Df(2R)NC32 (Myster et al., 2004, Gambetta and Mueller, 2009.8.18) Df(2R)NC50 (Myster et al., 2004) Df(2R)NC68 (Myster et al., 2004) Df(2R)NC98 (Myster et al., 2004) Df(2R)NC125 (Myster et al., 2004) Df(2R)NC167 (Myster et al., 2004) Df(2R)NC168 (Myster et al., 2004) Df(2R)NC195 (Myster et al., 2004) Df(2R)NC202 (Myster et al., 2004) Df(2R)NC207 (Myster et al., 2004) Df(2R)NC218 (Myster et al., 2004) Df(2R)NC219 (Myster et al., 2004) Df(2R)NC1198 (Myster et al., 2004) Df(2R)Nipped-D (Myster et al., 2004, Myster et al., 2004)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD13912} NA P{GD16319} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}l(2)SH0591SH0591 No P{lacW}vlck01109 No P{PZ}vlc07022 No insertion of mobile activating element P{EPgy2}vlcEY01995 NA P{XP}vlcd01566 NA P{XP}vlcd01574 NA miscellaneous insertions P{RS5}vlc5-HA-1849 NA P{wHy}vlcDG19809 NA PBac{RB}vlce00027 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cell-cell signaling inferred from electronic annotation with InterPro:IPR005026 (FlyBase Curators et al., 2004-) imaginal disc-derived leg morphogenesis non-traceable author statement (Gates, 2000.6.6)
Cellular Component
CV term Evidence References
septate junction inferred from sequence or structural similarity (Gates and Thummel, 2000)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions vlc allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 70090 DroID - A comprehensive database of gene and protein interactions. • FBgn0259978 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 46078
Orthologs
Genome-wide drosophilid orthologs	Dere\GG23178 Dgri\GH21456 Dmoj\GI19933 Dper\GL17527 Dpse\GA21040 Dsec\GM16518 Dvir\vlc Dwil\vlc Dyak\GE20549
Curated drosophilid orthologs	Dafs\vlc (Bartolome and Charlesworth, 2006) Dmir\vlc (Bartolome and Charlesworth, 2006, Bartolome and Charlesworth, 2006) Dpse\GA21040 (Bartolome and Charlesworth, 2006) Dvir\vlc   Dwil\vlc
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL011250-PA Aedes aegypti (mosquito) AGAP008983-PA Anopheles gambiae (mosquito) XP_001951468.1 Acyrthosiphon pisum (pea aphid) ENSBTAP00000002286 Bos taurus (bovine) CBP01321 Caenorhabditis briggsae (nematode) ENSCAFP00000027357 Canis familiaris (dog) ENSCINP00000013589 Ciona intestinalis (sea squirt) JA07150 Caenorhabditis japonica (nematode) RP31349 Caenorhabditis remanei (nematode) 218874 Capitella spl (polychaete worm) 301948 Daphnia pulex (daphnia) ENSDARP00000054451 Danio rerio (zebra fish) ENSECAP00000011620 Equus caballus (horse) ENSGACP00000010781 Gymnopilus aculeatus (mushroom) ENSP00000316377 Homo sapiens (human) ISCW016197-PA Ixodes scapularis (deer tick) 159884 Lottia gigantea (owl limpet) PHUM006243-PA Pediculus humanus (human body louse) ENSPTRP00000016750 Pan troglodytes (chimpanzee) Smp_035090.2 Schistosoma mansoni (trematode parasite) XP_974796.2 Tribolium castaneum (red flour beetle) ENSTRUP00000027117 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000025367 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • LH12915 ISCW016197 FBgn0237860 FBgn0064263 FBgn0064305 FBgn0182154 FBgn0171433 JGI_V11_301948 FBgn0081028 FBgn0155130 FBgn0142670 FBgn0128918 FBgn0115330 FBgn0088068 CPIJ010102 BGIBMGA009661 ACYPI000905 GB19111 AGAP008983 AAEL011250 PB22600 PHUM034510 GLEAN_09315
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	21713 y1 w67c23; P{wHy}vlcDG19809 12331 cn1 P{PZ}vlc07022/CyO; ry506 10366 y1 w67c23; P{lacW}vlck01109/CyO 19821 y1 w67c23; P{EPgy2}vlcEY01995/CyO
Harvard	- P{XP}vlcd01566 - PBac{RB}vlce00027
Kyoto	125429 w1118; P{RS5}vlc5-HA-1849 102190 y1 w67c23 ; P{lacW}vlck01109 / CyO
VDRC	v46230 w1118; P{GD16319}v46230 v46229 w1118; P{GD16319}v46229/TM3
Genomic Clones ( 2 )
	BACR27C13 BACR45O18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 97 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD44824 RE52822
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT04841 AT08112 AT20502 AT31022 GH08605 LD02257 LD02780 LD02914 LD03359 LD04690 LD06855 LD18416 LD18846 LD20626 LD30194 LD32728 LD34801 LD35389 LD36219 LD41556 LD43329 LD43938 LD45481 LP03908 RE02657 RE04271 RE14140 RE16996 RE17285 RE21302 RE21326 RE25050 RE25587 RE26116 RE27766 RE30443 RE30604 RE31843 RE43783 RE49606 RE50281 RE52987 RE59415 RE63383 RE65327 RE67065 RE69590 RE74313 RE75063 RH19811 RH48888 SD13670 SD13671 SD26207
Other clones	18834 32994 33780 63271 76898 81730 101094 107348 118044 120259 120303 147163 562171 CK01.6C.H9 CK01.26A.A6 Dmel_dig_010084_0679_1002 Dmel_dig_021009_0609_3489 Dmel_neb_014851_0354_1297 EC052711 EC053197 EC054197 EC054459 EC055468 EC055496 EK009823 EK024827 EK133522 EK143453 EK190161 EK223642 EK232951 EK239826 EK239839 EK249827 EK269701 EK270208 EN13841 EP11905 LD01882 LD11859 LD34719
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0259978 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 46078 5657267
Antibody Information
Other Information
Discoverer
Etymology
	The gene is named "vulcan" (after the malformed leg phenotype of mutants) after the Roman god who broke both his legs as he fell to earth upon being thrown from heaven by Jupiter. (Gates and Thummel, 2000)
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: vlc anon-41Fa (FlyBase, 1996-) Source for merge of: vlc anon-WO0118547.98 (FlyBase, 1996-) Source for merge of: vulcan CG8390 (FlyBase, 1996-)
Additional comments	Source for merge of vlc anon-WO0118547.98 was sequence comparison (date:051113). (FlyBase, 1996-) Source for merge of vulcan CG8390 was sequence comparison (date:000721). (FlyBase, 1996-)
Other Comments
	Area matching Drosophila EST AA263700. This EST overlaps EST AA978721. (Davies, 2001.3.15) Transcript mapped to position -0.5 to -2.8 in the ap region, less than 1kb from the 3' end of ap. (Bourgouin et al., 1992) Transcription unit neighbouring (3' of) ap transcription unit. (Bourgouin et al., 1992)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080129 NM_165442 NM_165444 NM_001169585 NM_001169586 RefSeq (Proteins) • NP_524868 NP_724425 NP_724427 NP_001163056 NP_001163057 DDBJ / EMBL / GenBank • AA263700 AA539190 AA978721 AAF57315 AAF57316 AAF78761 AAL29032 AAM68355 AAM68356 ACZ94336 ACZ94337 AF275628 AI512790 AW943748 AX093974 AY061484 CL705769 CZ472308 CZ472310 CZ477939 G01159 Entrez Gene - A searchable database of RefSeq genes. • 46078 UniProtKB/TrEMBL • A1Z6H3 A1Z6H4 Q7K1T1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Guanylate-kinase-associated protein (IPR005026)
Linkouts
	BioGRID - A database of protein and genetic interactions • 70090 DroID - A comprehensive database of gene and protein interactions. • FBgn0259978 DRSC - Results from RNAi screens. • FBgn0259978 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259978 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0259978 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 46078 5657267 InParanoid A subset of ortholog calls from InParanoid. • AAEL011250-PA Aedes aegypti (mosquito) AGAP008983-PA Anopheles gambiae (mosquito) XP_001951468.1 Acyrthosiphon pisum (pea aphid) ENSBTAP00000002286 Bos taurus (bovine) CBP01321 Caenorhabditis briggsae (nematode) ENSCAFP00000027357 Canis familiaris (dog) ENSCINP00000013589 Ciona intestinalis (sea squirt) JA07150 Caenorhabditis japonica (nematode) RP31349 Caenorhabditis remanei (nematode) 218874 Capitella spl (polychaete worm) 301948 Daphnia pulex (daphnia) ENSDARP00000054451 Danio rerio (zebra fish) ENSECAP00000011620 Equus caballus (horse) ENSGACP00000010781 Gymnopilus aculeatus (mushroom) ENSP00000316377 Homo sapiens (human) ISCW016197-PA Ixodes scapularis (deer tick) 159884 Lottia gigantea (owl limpet) PHUM006243-PA Pediculus humanus (human body louse) ENSPTRP00000016750 Pan troglodytes (chimpanzee) Smp_035090.2 Schistosoma mansoni (trematode parasite) XP_974796.2 Tribolium castaneum (red flour beetle) ENSTRUP00000027117 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000025367 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 46078 modMine - Data generated by the modENCODE project. • FBgn0259978 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • LH12915 ISCW016197 FBgn0237860 FBgn0064263 FBgn0064305 FBgn0182154 FBgn0171433 JGI_V11_301948 FBgn0081028 FBgn0155130 FBgn0142670 FBgn0128918 FBgn0115330 FBgn0088068 CPIJ010102 BGIBMGA009661 ACYPI000905 GB19111 AGAP008983 AAEL011250 PB22600 PHUM034510 GLEAN_09315
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	anon-41Fa   anon-WO0118547.98   CG8390 (Seinen et al., 2010) l(2)07022 (Spradling et al., 1999, BDGP Project Members, 1994-1999, ) unnamed (Gates and Thummel, 2000) vlc (Bartolome and Charlesworth, 2006, Christensen et al., 2008.12.28) X (Bourgouin et al., 1992)
Name Synonym	anon-41Fa   transcription unit X (Bourgouin et al., 1992) vulcan (Gates and Thummel, 2000, Dimitri et al., 2003, Gambetta and Mueller, 2009.8.18)
Secondary FlyBase IDs
	FBgn0010633 FBgn0014098 FBgn0033036 FBgn0061521
References ( 36 )
Generate a list of	All references relating to this gene ( 36 )
List References by type	Research paper  ( 9 ) Supplementary material  ( 5 ) Review  ( 1 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 2 ) FlyBase analysis  ( 3 ) Computer file  ( 4 ) Patent  ( 1 ) DNA/RNA sequence record  ( 2 )
Recent research papers ( 1 )
	Seinen et al., 2010, PLoS ONE 5(10): e13119 RNAi Experiments in D. melanogaster: Solutions to the Overlooked Problem of Off-Targets Shared by Independent dsRNAs. [FBrf0212057] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...