General Information Symbol Dmel\ l(2)35CcSpecies D. melanogaster Name lethal (2) 35Cc Annotation symbol CG15266 Feature type protein_coding_gene FlyBase ID FBgn0259982 Gene Model Status Current Stock availability 7 publicly
available Also Known As BG:DS07295.5, l(2)br50 Genomic Location Chromosome (arm) 2L Recombination map 2-[51] Cytogenetic map 35C5-35C5 Sequence location 2L:15,256,581..15,257,642 [+]
Genomic Maps
Summary Information Automatically generated summary
See sections below for more information The gene
lethal (2) 35Cc is referred to in FlyBase by the symbol
Dmel\l(2)35Cc (CG15266, FBgn0259982). It is a protein_coding_gene from
Drosophila melanogaster . An electronic pipeline based on InterPro domains suggests that it has the
molecular function : unfolded protein binding. An electronic pipeline based on InterPro domains suggests that it is involved in the
biological process : protein folding.
5 alleles are reported . No phenotypic data is available. It has
2 annotated transcripts and
2 annotated polypeptides .
Protein features are: Prefoldin; Prefoldin alpha subunit; Prefoldin subunit. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1631876_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of l(2)35Cc. Gene sequence location is
2L:15256581..15257642 .
User Contributed Data
Phenotypic Description from the Red Book (Lindsley
& Zimm 1992) Gene/Allele symbols may differ
from current usage l(2)35Cc
No known alleles; existence inferred from lethality
associated with Df(2L)rd9.
Recent Updates
Description
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It currently only tracks new links between this FlyBase report and other
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FB2013_03
FB2013_02
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Detailed Mapping Data
FlyBase Computed Cytological Location
Experimentally Determined Cytological Location
Experimentally Determined Recombination Data
Location Left of (cM) Right of (cM) Notes Gene Model & Products Comments on Gene
Model Gene model reviewed during 5.42
Gene model reviewed during 5.43
Gene model reviewed during 5.48
Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data Annotated Transcripts Additional Transcript Data
& Comments Reported size (kB) Comments External Data Crossreferences
Polypeptide Data Annotated
Polypeptides Additional Polypeptide
Data & Comments Reported size (kDa) Comments External Data Linkouts Crossreferences
domains - A database of protein families, domains, and functional sites
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank UniProtKB/Swiss-Prot UniProtKB/TrEMBL Mapped Features Mapped Features have been reorganized, please
see this article for details. Additional mapped features and mutations can
be found on GBrowse or related reports. External Data Linkouts Crossreferences Expression Data Transcript Expression
Additional Descriptive Data
Marker for Subcellular Localization CV Term Polypeptide Expression
Additional Descriptive Data
Marker for Subcellular Localization (GO Cellular Component) Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference
FlyAtlas Anatomy Microarray
Linear, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
154.15
Larval Midgut
18.4
Larval Hindgut
47.2
Larval Malpighian Tubules
84
Larval Fat Body
32
Larval Salivary Gland
107.3
Larval Trachea
96.25
Larval Carcass
36.9
Adult Head
39.6
Adult Eye
43.725
Adult Brain
69.4
Adult Thoracic-Abdominal Ganglion
47
Adult Crop
76.8
Adult Midgut
28
Adult Hindgut
48.9
Adult Malpighian Tubules
31.6
Adult Fat Body
11.3
Adult Salivary Gland
49.3
Adult Heart
23.825
Adult VirginFemale Spermatheca
13.4
Adult InseminatedFemale Spermatheca
24.4
Adult Ovary
243
Adult Testis
88.9
Adult Male Accessory Gland
64.8
Adult Carcass
20.6
Expression Level Scale
None
Low
Moderate
Linear, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
154.15
Larval Midgut
18.4
Larval Hindgut
47.2
Larval Malpighian Tubules
84
Larval Fat Body
32
Larval Salivary Gland
107.3
Larval Trachea
96.25
Larval Carcass
36.9
Adult Head
39.6
Adult Eye
43.725
Adult Brain
69.4
Adult Thoracic-Abdominal Ganglion
47
Adult Crop
76.8
Adult Midgut
28
Adult Hindgut
48.9
Adult Malpighian Tubules
31.6
Adult Fat Body
11.3
Adult Salivary Gland
49.3
Adult Heart
23.825
Adult VirginFemale Spermatheca
13.4
Adult InseminatedFemale Spermatheca
24.4
Adult Ovary
243
Adult Testis
88.9
Adult Male Accessory Gland
64.8
Adult Carcass
20.6
Expression Level Scale
None
Low
Moderate
High
Linear, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
154.15
Larval Midgut
18.4
Larval Hindgut
47.2
Larval Malpighian Tubules
84
Larval Fat Body
32
Larval Salivary Gland
107.3
Larval Trachea
96.25
Larval Carcass
36.9
Adult Head
39.6
Adult Eye
43.725
Adult Brain
69.4
Adult Thoracic-Abdominal Ganglion
47
Adult Crop
76.8
Adult Midgut
28
Adult Hindgut
48.9
Adult Malpighian Tubules
31.6
Adult Fat Body
11.3
Adult Salivary Gland
49.3
Adult Heart
23.825
Adult VirginFemale Spermatheca
13.4
Adult InseminatedFemale Spermatheca
24.4
Adult Ovary
243
Adult Testis
88.9
Adult Male Accessory Gland
64.8
Adult Carcass
20.6
Expression Level Scale
None
Low
Moderate
High
Very high
Linear, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
154.15
Larval Midgut
18.4
Larval Hindgut
47.2
Larval Malpighian Tubules
84
Larval Fat Body
32
Larval Salivary Gland
107.3
Larval Trachea
96.25
Larval Carcass
36.9
Adult Head
39.6
Adult Eye
43.725
Adult Brain
69.4
Adult Thoracic-Abdominal Ganglion
47
Adult Crop
76.8
Adult Midgut
28
Adult Hindgut
48.9
Adult Malpighian Tubules
31.6
Adult Fat Body
11.3
Adult Salivary Gland
49.3
Adult Heart
23.825
Adult VirginFemale Spermatheca
13.4
Adult InseminatedFemale Spermatheca
24.4
Adult Ovary
243
Adult Testis
88.9
Adult Male Accessory Gland
64.8
Adult Carcass
20.6
Expression Level Scale
Very high
log, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
154.15
Larval Midgut
18.4
Larval Hindgut
47.2
Larval Malpighian Tubules
84
Larval Fat Body
32
Larval Salivary Gland
107.3
Larval Trachea
96.25
Larval Carcass
36.9
Adult Head
39.6
Adult Eye
43.725
Adult Brain
69.4
Adult Thoracic-Abdominal Ganglion
47
Adult Crop
76.8
Adult Midgut
28
Adult Hindgut
48.9
Adult Malpighian Tubules
31.6
Adult Fat Body
11.3
Adult Salivary Gland
49.3
Adult Heart
23.825
Adult VirginFemale Spermatheca
13.4
Adult InseminatedFemale Spermatheca
24.4
Adult Ovary
243
Adult Testis
88.9
Adult Male Accessory Gland
64.8
Adult Carcass
20.6
Expression Level Scale
None
Low
Moderate
log, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
154.15
Larval Midgut
18.4
Larval Hindgut
47.2
Larval Malpighian Tubules
84
Larval Fat Body
32
Larval Salivary Gland
107.3
Larval Trachea
96.25
Larval Carcass
36.9
Adult Head
39.6
Adult Eye
43.725
Adult Brain
69.4
Adult Thoracic-Abdominal Ganglion
47
Adult Crop
76.8
Adult Midgut
28
Adult Hindgut
48.9
Adult Malpighian Tubules
31.6
Adult Fat Body
11.3
Adult Salivary Gland
49.3
Adult Heart
23.825
Adult VirginFemale Spermatheca
13.4
Adult InseminatedFemale Spermatheca
24.4
Adult Ovary
243
Adult Testis
88.9
Adult Male Accessory Gland
64.8
Adult Carcass
20.6
Expression Level Scale
None
Low
Moderate
High
log, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
154.15
Larval Midgut
18.4
Larval Hindgut
47.2
Larval Malpighian Tubules
84
Larval Fat Body
32
Larval Salivary Gland
107.3
Larval Trachea
96.25
Larval Carcass
36.9
Adult Head
39.6
Adult Eye
43.725
Adult Brain
69.4
Adult Thoracic-Abdominal Ganglion
47
Adult Crop
76.8
Adult Midgut
28
Adult Hindgut
48.9
Adult Malpighian Tubules
31.6
Adult Fat Body
11.3
Adult Salivary Gland
49.3
Adult Heart
23.825
Adult VirginFemale Spermatheca
13.4
Adult InseminatedFemale Spermatheca
24.4
Adult Ovary
243
Adult Testis
88.9
Adult Male Accessory Gland
64.8
Adult Carcass
20.6
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
154.15
Larval Midgut
18.4
Larval Hindgut
47.2
Larval Malpighian Tubules
84
Larval Fat Body
32
Larval Salivary Gland
107.3
Larval Trachea
96.25
Larval Carcass
36.9
Adult Head
39.6
Adult Eye
43.725
Adult Brain
69.4
Adult Thoracic-Abdominal Ganglion
47
Adult Crop
76.8
Adult Midgut
28
Adult Hindgut
48.9
Adult Malpighian Tubules
31.6
Adult Fat Body
11.3
Adult Salivary Gland
49.3
Adult Heart
23.825
Adult VirginFemale Spermatheca
13.4
Adult InseminatedFemale Spermatheca
24.4
Adult Ovary
243
Adult Testis
88.9
Adult Male Accessory Gland
64.8
Adult Carcass
20.6
Expression Level Scale
None
Low
Moderate
High
Very high
Heatmap
Tissue
Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass
FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level
Tissue
Adult Expression Level
NA
Head
39.6
NA
Eye
43.725
NA
Brain
69.4
154.15
Central Nervous System
NA
NA
Thoracic-Abdominal Ganglion
47
NA
Crop
76.8
no informative data
Midgut
28
47.2
Hindgut
48.9
84
Malpighian Tubules
31.6
32
Fat Body
no informative data
107.3
Salivary Gland
49.3
NA
Heart
23.825
96.25
Trachea
NA
NA
VirginFemale Spermatheca
no informative data
NA
InseminatedFemale Spermatheca
no informative data
NA
Ovary
243
NA
Testis
88.9
NA
Male Accessory Gland
64.8
36.9
Carcass
no informative data
modENCODE Anatomy RNA-Seq
Linear, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
9
central nervous system, larvae L3
9
central nervous system, pupae P8
4
head, virgin 1-day female
3
head, virgin 4-day female
2
head, virgin 20-day female
2
head, mated 1-day female
1
head, mated 4-day female
2
head, mated 20-day female
2
head, mated 1-day male
2
head, mated 4-day male
3
head, mated 20-day male
4
salivary gland, larvae L3 wandering
1
salivary gland, white prepupae
0
digestive system, larvae L3 wandering
4
digestive system, 1-day adult
3
digestive system, 4-day adult
2
digestive system, 20-day adult
2
fat body, larvae L3 wandering
1
fat body, white prepupae
3
fat body, pupae P8
6
carcass, larvae L3 wandering
6
carcass, 1-day adult
2
carcass, 4-day adult
2
carcass, 20-day adult
2
ovary, virgin 4-day female
18
ovary, mated 4-day female
16
testis, mated 4-day male
10
accessory gland, mated 4-day male
2
Expression Level Scale
Very low
Low
Moderate
Linear, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
9
central nervous system, larvae L3
9
central nervous system, pupae P8
4
head, virgin 1-day female
3
head, virgin 4-day female
2
head, virgin 20-day female
2
head, mated 1-day female
1
head, mated 4-day female
2
head, mated 20-day female
2
head, mated 1-day male
2
head, mated 4-day male
3
head, mated 20-day male
4
salivary gland, larvae L3 wandering
1
salivary gland, white prepupae
0
digestive system, larvae L3 wandering
4
digestive system, 1-day adult
3
digestive system, 4-day adult
2
digestive system, 20-day adult
2
fat body, larvae L3 wandering
1
fat body, white prepupae
3
fat body, pupae P8
6
carcass, larvae L3 wandering
6
carcass, 1-day adult
2
carcass, 4-day adult
2
carcass, 20-day adult
2
ovary, virgin 4-day female
18
ovary, mated 4-day female
16
testis, mated 4-day male
10
accessory gland, mated 4-day male
2
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
9
central nervous system, larvae L3
9
central nervous system, pupae P8
4
head, virgin 1-day female
3
head, virgin 4-day female
2
head, virgin 20-day female
2
head, mated 1-day female
1
head, mated 4-day female
2
head, mated 20-day female
2
head, mated 1-day male
2
head, mated 4-day male
3
head, mated 20-day male
4
salivary gland, larvae L3 wandering
1
salivary gland, white prepupae
0
digestive system, larvae L3 wandering
4
digestive system, 1-day adult
3
digestive system, 4-day adult
2
digestive system, 20-day adult
2
fat body, larvae L3 wandering
1
fat body, white prepupae
3
fat body, pupae P8
6
carcass, larvae L3 wandering
6
carcass, 1-day adult
2
carcass, 4-day adult
2
carcass, 20-day adult
2
ovary, virgin 4-day female
18
ovary, mated 4-day female
16
testis, mated 4-day male
10
accessory gland, mated 4-day male
2
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
9
central nervous system, larvae L3
9
central nervous system, pupae P8
4
head, virgin 1-day female
3
head, virgin 4-day female
2
head, virgin 20-day female
2
head, mated 1-day female
1
head, mated 4-day female
2
head, mated 20-day female
2
head, mated 1-day male
2
head, mated 4-day male
3
head, mated 20-day male
4
salivary gland, larvae L3 wandering
1
salivary gland, white prepupae
0
digestive system, larvae L3 wandering
4
digestive system, 1-day adult
3
digestive system, 4-day adult
2
digestive system, 20-day adult
2
fat body, larvae L3 wandering
1
fat body, white prepupae
3
fat body, pupae P8
6
carcass, larvae L3 wandering
6
carcass, 1-day adult
2
carcass, 4-day adult
2
carcass, 20-day adult
2
ovary, virgin 4-day female
18
ovary, mated 4-day female
16
testis, mated 4-day male
10
accessory gland, mated 4-day male
2
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
9
central nervous system, larvae L3
9
central nervous system, pupae P8
4
head, virgin 1-day female
3
head, virgin 4-day female
2
head, virgin 20-day female
2
head, mated 1-day female
1
head, mated 4-day female
2
head, mated 20-day female
2
head, mated 1-day male
2
head, mated 4-day male
3
head, mated 20-day male
4
salivary gland, larvae L3 wandering
1
salivary gland, white prepupae
0
digestive system, larvae L3 wandering
4
digestive system, 1-day adult
3
digestive system, 4-day adult
2
digestive system, 20-day adult
2
fat body, larvae L3 wandering
1
fat body, white prepupae
3
fat body, pupae P8
6
carcass, larvae L3 wandering
6
carcass, 1-day adult
2
carcass, 4-day adult
2
carcass, 20-day adult
2
ovary, virgin 4-day female
18
ovary, mated 4-day female
16
testis, mated 4-day male
10
accessory gland, mated 4-day male
2
Expression Level Scale
Very low
Low
Moderate
log, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
9
central nervous system, larvae L3
9
central nervous system, pupae P8
4
head, virgin 1-day female
3
head, virgin 4-day female
2
head, virgin 20-day female
2
head, mated 1-day female
1
head, mated 4-day female
2
head, mated 20-day female
2
head, mated 1-day male
2
head, mated 4-day male
3
head, mated 20-day male
4
salivary gland, larvae L3 wandering
1
salivary gland, white prepupae
0
digestive system, larvae L3 wandering
4
digestive system, 1-day adult
3
digestive system, 4-day adult
2
digestive system, 20-day adult
2
fat body, larvae L3 wandering
1
fat body, white prepupae
3
fat body, pupae P8
6
carcass, larvae L3 wandering
6
carcass, 1-day adult
2
carcass, 4-day adult
2
carcass, 20-day adult
2
ovary, virgin 4-day female
18
ovary, mated 4-day female
16
testis, mated 4-day male
10
accessory gland, mated 4-day male
2
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
9
central nervous system, larvae L3
9
central nervous system, pupae P8
4
head, virgin 1-day female
3
head, virgin 4-day female
2
head, virgin 20-day female
2
head, mated 1-day female
1
head, mated 4-day female
2
head, mated 20-day female
2
head, mated 1-day male
2
head, mated 4-day male
3
head, mated 20-day male
4
salivary gland, larvae L3 wandering
1
salivary gland, white prepupae
0
digestive system, larvae L3 wandering
4
digestive system, 1-day adult
3
digestive system, 4-day adult
2
digestive system, 20-day adult
2
fat body, larvae L3 wandering
1
fat body, white prepupae
3
fat body, pupae P8
6
carcass, larvae L3 wandering
6
carcass, 1-day adult
2
carcass, 4-day adult
2
carcass, 20-day adult
2
ovary, virgin 4-day female
18
ovary, mated 4-day female
16
testis, mated 4-day male
10
accessory gland, mated 4-day male
2
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
9
central nervous system, larvae L3
9
central nervous system, pupae P8
4
head, virgin 1-day female
3
head, virgin 4-day female
2
head, virgin 20-day female
2
head, mated 1-day female
1
head, mated 4-day female
2
head, mated 20-day female
2
head, mated 1-day male
2
head, mated 4-day male
3
head, mated 20-day male
4
salivary gland, larvae L3 wandering
1
salivary gland, white prepupae
0
digestive system, larvae L3 wandering
4
digestive system, 1-day adult
3
digestive system, 4-day adult
2
digestive system, 20-day adult
2
fat body, larvae L3 wandering
1
fat body, white prepupae
3
fat body, pupae P8
6
carcass, larvae L3 wandering
6
carcass, 1-day adult
2
carcass, 4-day adult
2
carcass, 20-day adult
2
ovary, virgin 4-day female
18
ovary, mated 4-day female
16
testis, mated 4-day male
10
accessory gland, mated 4-day male
2
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Tissue
Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male
modENCODE Development RNA-Seq
Linear, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
41
embryo 02-04hr
44
embryo 04-06hr
32
embryo 06-08hr
22
embryo 08-10hr
26
embryo 10-12hr
24
embryo 12-14hr
16
embryo 14-16hr
11
embryo 16-18hr
10
embryo 18-20hr
5
embryo 20-22hr
7
embryo 22-24hr
8
larva L1
7
larva L2
8
larva L3 12hr old
6
larva L3 puffstage 1-2
8
larva L3 puffstage 3-6
10
larva L3 puffstage 7-9
14
white prepupae new
12
white prepupae 12hr
13
white prepupae 24hr
16
pupae 2d postWPP
12
pupae 3d postWPP
7
pupae 4d postWPP
5
adult male 01day
9
adult male 05day
10
adult male 30day
9
adult female 01day
11
adult female 05day
23
adult female 30day
22
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
(41)
embryo 02-04hr
(44)
embryo 04-06hr
(32)
embryo 06-08hr
22
embryo 08-10hr
26
embryo 10-12hr
24
embryo 12-14hr
16
embryo 14-16hr
11
embryo 16-18hr
10
embryo 18-20hr
5
embryo 20-22hr
7
embryo 22-24hr
8
larva L1
7
larva L2
8
larva L3 12hr old
6
larva L3 puffstage 1-2
8
larva L3 puffstage 3-6
10
larva L3 puffstage 7-9
14
white prepupae new
12
white prepupae 12hr
13
white prepupae 24hr
16
pupae 2d postWPP
12
pupae 3d postWPP
7
pupae 4d postWPP
5
adult male 01day
9
adult male 05day
10
adult male 30day
9
adult female 01day
11
adult female 05day
23
adult female 30day
22
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
41
embryo 02-04hr
44
embryo 04-06hr
32
embryo 06-08hr
22
embryo 08-10hr
26
embryo 10-12hr
24
embryo 12-14hr
16
embryo 14-16hr
11
embryo 16-18hr
10
embryo 18-20hr
5
embryo 20-22hr
7
embryo 22-24hr
8
larva L1
7
larva L2
8
larva L3 12hr old
6
larva L3 puffstage 1-2
8
larva L3 puffstage 3-6
10
larva L3 puffstage 7-9
14
white prepupae new
12
white prepupae 12hr
13
white prepupae 24hr
16
pupae 2d postWPP
12
pupae 3d postWPP
7
pupae 4d postWPP
5
adult male 01day
9
adult male 05day
10
adult male 30day
9
adult female 01day
11
adult female 05day
23
adult female 30day
22
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
41
embryo 02-04hr
44
embryo 04-06hr
32
embryo 06-08hr
22
embryo 08-10hr
26
embryo 10-12hr
24
embryo 12-14hr
16
embryo 14-16hr
11
embryo 16-18hr
10
embryo 18-20hr
5
embryo 20-22hr
7
embryo 22-24hr
8
larva L1
7
larva L2
8
larva L3 12hr old
6
larva L3 puffstage 1-2
8
larva L3 puffstage 3-6
10
larva L3 puffstage 7-9
14
white prepupae new
12
white prepupae 12hr
13
white prepupae 24hr
16
pupae 2d postWPP
12
pupae 3d postWPP
7
pupae 4d postWPP
5
adult male 01day
9
adult male 05day
10
adult male 30day
9
adult female 01day
11
adult female 05day
23
adult female 30day
22
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
41
embryo 02-04hr
44
embryo 04-06hr
32
embryo 06-08hr
22
embryo 08-10hr
26
embryo 10-12hr
24
embryo 12-14hr
16
embryo 14-16hr
11
embryo 16-18hr
10
embryo 18-20hr
5
embryo 20-22hr
7
embryo 22-24hr
8
larva L1
7
larva L2
8
larva L3 12hr old
6
larva L3 puffstage 1-2
8
larva L3 puffstage 3-6
10
larva L3 puffstage 7-9
14
white prepupae new
12
white prepupae 12hr
13
white prepupae 24hr
16
pupae 2d postWPP
12
pupae 3d postWPP
7
pupae 4d postWPP
5
adult male 01day
9
adult male 05day
10
adult male 30day
9
adult female 01day
11
adult female 05day
23
adult female 30day
22
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
log, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
(41)
embryo 02-04hr
(44)
embryo 04-06hr
32
embryo 06-08hr
22
embryo 08-10hr
26
embryo 10-12hr
24
embryo 12-14hr
16
embryo 14-16hr
11
embryo 16-18hr
10
embryo 18-20hr
5
embryo 20-22hr
7
embryo 22-24hr
8
larva L1
7
larva L2
8
larva L3 12hr old
6
larva L3 puffstage 1-2
8
larva L3 puffstage 3-6
10
larva L3 puffstage 7-9
14
white prepupae new
12
white prepupae 12hr
13
white prepupae 24hr
16
pupae 2d postWPP
12
pupae 3d postWPP
7
pupae 4d postWPP
5
adult male 01day
9
adult male 05day
10
adult male 30day
9
adult female 01day
11
adult female 05day
23
adult female 30day
22
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
41
embryo 02-04hr
44
embryo 04-06hr
32
embryo 06-08hr
22
embryo 08-10hr
26
embryo 10-12hr
24
embryo 12-14hr
16
embryo 14-16hr
11
embryo 16-18hr
10
embryo 18-20hr
5
embryo 20-22hr
7
embryo 22-24hr
8
larva L1
7
larva L2
8
larva L3 12hr old
6
larva L3 puffstage 1-2
8
larva L3 puffstage 3-6
10
larva L3 puffstage 7-9
14
white prepupae new
12
white prepupae 12hr
13
white prepupae 24hr
16
pupae 2d postWPP
12
pupae 3d postWPP
7
pupae 4d postWPP
5
adult male 01day
9
adult male 05day
10
adult male 30day
9
adult female 01day
11
adult female 05day
23
adult female 30day
22
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
41
embryo 02-04hr
44
embryo 04-06hr
32
embryo 06-08hr
22
embryo 08-10hr
26
embryo 10-12hr
24
embryo 12-14hr
16
embryo 14-16hr
11
embryo 16-18hr
10
embryo 18-20hr
5
embryo 20-22hr
7
embryo 22-24hr
8
larva L1
7
larva L2
8
larva L3 12hr old
6
larva L3 puffstage 1-2
8
larva L3 puffstage 3-6
10
larva L3 puffstage 7-9
14
white prepupae new
12
white prepupae 12hr
13
white prepupae 24hr
16
pupae 2d postWPP
12
pupae 3d postWPP
7
pupae 4d postWPP
5
adult male 01day
9
adult male 05day
10
adult male 30day
9
adult female 01day
11
adult female 05day
23
adult female 30day
22
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Developmental Stage
Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day
modENCODE Cell Lines RNA-Seq
Linear, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
12
Schneider line 2 Sg4
9
embryonic 1182-4H
8
embryonic GM2
3
embryonic Kc167
4
embryonic S1
13
embryonic S3
5
leg disc CME L1
11
wing disc CME-W2
4
wing disc ML-DmD8
4
wing disc ML-DmD9
9
wing disc ML-DmD16-c3
26
wing disc ML-DmD21
25
wing disc ML-DmD32
7
haltere disc ML-DmD17-c3
9
eye-antennal disc ML-DmD11
5
antennal disc ML-DmD20-c5
12
mixed discs ML-DmD4-c1
9
CNS ML-DmBG1-c1
9
CNS ML-DmBG2-c2
9
tumorous blood cells mbn2
3
ovary fGS/OSS
26
ovary OSC
10
ovary OSS
7
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
12
Schneider line 2 Sg4
9
embryonic 1182-4H
8
embryonic GM2
3
embryonic Kc167
4
embryonic S1
13
embryonic S3
5
leg disc CME L1
11
wing disc CME-W2
4
wing disc ML-DmD8
4
wing disc ML-DmD9
9
wing disc ML-DmD16-c3
26
wing disc ML-DmD21
25
wing disc ML-DmD32
7
haltere disc ML-DmD17-c3
9
eye-antennal disc ML-DmD11
5
antennal disc ML-DmD20-c5
12
mixed discs ML-DmD4-c1
9
CNS ML-DmBG1-c1
9
CNS ML-DmBG2-c2
9
tumorous blood cells mbn2
3
ovary fGS/OSS
26
ovary OSC
10
ovary OSS
7
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
12
Schneider line 2 Sg4
9
embryonic 1182-4H
8
embryonic GM2
3
embryonic Kc167
4
embryonic S1
13
embryonic S3
5
leg disc CME L1
11
wing disc CME-W2
4
wing disc ML-DmD8
4
wing disc ML-DmD9
9
wing disc ML-DmD16-c3
26
wing disc ML-DmD21
25
wing disc ML-DmD32
7
haltere disc ML-DmD17-c3
9
eye-antennal disc ML-DmD11
5
antennal disc ML-DmD20-c5
12
mixed discs ML-DmD4-c1
9
CNS ML-DmBG1-c1
9
CNS ML-DmBG2-c2
9
tumorous blood cells mbn2
3
ovary fGS/OSS
26
ovary OSC
10
ovary OSS
7
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
12
Schneider line 2 Sg4
9
embryonic 1182-4H
8
embryonic GM2
3
embryonic Kc167
4
embryonic S1
13
embryonic S3
5
leg disc CME L1
11
wing disc CME-W2
4
wing disc ML-DmD8
4
wing disc ML-DmD9
9
wing disc ML-DmD16-c3
26
wing disc ML-DmD21
25
wing disc ML-DmD32
7
haltere disc ML-DmD17-c3
9
eye-antennal disc ML-DmD11
5
antennal disc ML-DmD20-c5
12
mixed discs ML-DmD4-c1
9
CNS ML-DmBG1-c1
9
CNS ML-DmBG2-c2
9
tumorous blood cells mbn2
3
ovary fGS/OSS
26
ovary OSC
10
ovary OSS
7
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
12
Schneider line 2 Sg4
9
embryonic 1182-4H
8
embryonic GM2
3
embryonic Kc167
4
embryonic S1
13
embryonic S3
5
leg disc CME L1
11
wing disc CME-W2
4
wing disc ML-DmD8
4
wing disc ML-DmD9
9
wing disc ML-DmD16-c3
26
wing disc ML-DmD21
25
wing disc ML-DmD32
7
haltere disc ML-DmD17-c3
9
eye-antennal disc ML-DmD11
5
antennal disc ML-DmD20-c5
12
mixed discs ML-DmD4-c1
9
CNS ML-DmBG1-c1
9
CNS ML-DmBG2-c2
9
tumorous blood cells mbn2
3
ovary fGS/OSS
26
ovary OSC
10
ovary OSS
7
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
12
Schneider line 2 Sg4
9
embryonic 1182-4H
8
embryonic GM2
3
embryonic Kc167
4
embryonic S1
13
embryonic S3
5
leg disc CME L1
11
wing disc CME-W2
4
wing disc ML-DmD8
4
wing disc ML-DmD9
9
wing disc ML-DmD16-c3
26
wing disc ML-DmD21
25
wing disc ML-DmD32
7
haltere disc ML-DmD17-c3
9
eye-antennal disc ML-DmD11
5
antennal disc ML-DmD20-c5
12
mixed discs ML-DmD4-c1
9
CNS ML-DmBG1-c1
9
CNS ML-DmBG2-c2
9
tumorous blood cells mbn2
3
ovary fGS/OSS
26
ovary OSC
10
ovary OSS
7
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
12
Schneider line 2 Sg4
9
embryonic 1182-4H
8
embryonic GM2
3
embryonic Kc167
4
embryonic S1
13
embryonic S3
5
leg disc CME L1
11
wing disc CME-W2
4
wing disc ML-DmD8
4
wing disc ML-DmD9
9
wing disc ML-DmD16-c3
26
wing disc ML-DmD21
25
wing disc ML-DmD32
7
haltere disc ML-DmD17-c3
9
eye-antennal disc ML-DmD11
5
antennal disc ML-DmD20-c5
12
mixed discs ML-DmD4-c1
9
CNS ML-DmBG1-c1
9
CNS ML-DmBG2-c2
9
tumorous blood cells mbn2
3
ovary fGS/OSS
26
ovary OSC
10
ovary OSS
7
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
12
Schneider line 2 Sg4
9
embryonic 1182-4H
8
embryonic GM2
3
embryonic Kc167
4
embryonic S1
13
embryonic S3
5
leg disc CME L1
11
wing disc CME-W2
4
wing disc ML-DmD8
4
wing disc ML-DmD9
9
wing disc ML-DmD16-c3
26
wing disc ML-DmD21
25
wing disc ML-DmD32
7
haltere disc ML-DmD17-c3
9
eye-antennal disc ML-DmD11
5
antennal disc ML-DmD20-c5
12
mixed discs ML-DmD4-c1
9
CNS ML-DmBG1-c1
9
CNS ML-DmBG2-c2
9
tumorous blood cells mbn2
3
ovary fGS/OSS
26
ovary OSC
10
ovary OSS
7
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Cell Line
Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS
modENCODE Treatments RNA-Seq
Linear, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
7
cold shock, 4-day adult
3
heat shock, 4-day adult
5
Cadmium 50 mM 6 hrs, larvae L3
3
Cadmium 50 mM 12 hrs, larvae L3
4
Cadmium 50 mM 48 hrs, 4-day adult
6
Cadmium 100 mM 48 hrs, 4-day adult
9
Copper 0.5 mM 12 hrs, larvae L3
3
Copper 15 mM 48 hrs, 4-day adult
3
Zinc 5 mM 12 hrs, larvae L3
3
Zinc 4.5 mM 48 hrs, 4-day adult
5
Ethanol 2.5% 3 hrs, larvae L3
12
Ethanol 5% 3 hrs, larvae L3
3
Ethanol 10% 3 hrs, larvae L3
2
Caffeine 1.5 mg/ml 4 hrs, larvae L3
1
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
8
Caffeine 25 mg/ml 48 hrs, 4-day adult
4
Paraquat 5 mM 48 hrs, 4-day adult
13
Paraquat 10 mM 48 hrs, 4-day adult
6
Rotenone 2 μg 12 hrs, larvae L3
3
Rotenone 8 μg 12 hrs, larvae L3
1
Expression Level Scale
Very low
Low
Moderate
Linear, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
7
cold shock, 4-day adult
3
heat shock, 4-day adult
5
Cadmium 50 mM 6 hrs, larvae L3
3
Cadmium 50 mM 12 hrs, larvae L3
4
Cadmium 50 mM 48 hrs, 4-day adult
6
Cadmium 100 mM 48 hrs, 4-day adult
9
Copper 0.5 mM 12 hrs, larvae L3
3
Copper 15 mM 48 hrs, 4-day adult
3
Zinc 5 mM 12 hrs, larvae L3
3
Zinc 4.5 mM 48 hrs, 4-day adult
5
Ethanol 2.5% 3 hrs, larvae L3
12
Ethanol 5% 3 hrs, larvae L3
3
Ethanol 10% 3 hrs, larvae L3
2
Caffeine 1.5 mg/ml 4 hrs, larvae L3
1
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
8
Caffeine 25 mg/ml 48 hrs, 4-day adult
4
Paraquat 5 mM 48 hrs, 4-day adult
13
Paraquat 10 mM 48 hrs, 4-day adult
6
Rotenone 2 μg 12 hrs, larvae L3
3
Rotenone 8 μg 12 hrs, larvae L3
1
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
7
cold shock, 4-day adult
3
heat shock, 4-day adult
5
Cadmium 50 mM 6 hrs, larvae L3
3
Cadmium 50 mM 12 hrs, larvae L3
4
Cadmium 50 mM 48 hrs, 4-day adult
6
Cadmium 100 mM 48 hrs, 4-day adult
9
Copper 0.5 mM 12 hrs, larvae L3
3
Copper 15 mM 48 hrs, 4-day adult
3
Zinc 5 mM 12 hrs, larvae L3
3
Zinc 4.5 mM 48 hrs, 4-day adult
5
Ethanol 2.5% 3 hrs, larvae L3
12
Ethanol 5% 3 hrs, larvae L3
3
Ethanol 10% 3 hrs, larvae L3
2
Caffeine 1.5 mg/ml 4 hrs, larvae L3
1
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
8
Caffeine 25 mg/ml 48 hrs, 4-day adult
4
Paraquat 5 mM 48 hrs, 4-day adult
13
Paraquat 10 mM 48 hrs, 4-day adult
6
Rotenone 2 μg 12 hrs, larvae L3
3
Rotenone 8 μg 12 hrs, larvae L3
1
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
7
cold shock, 4-day adult
3
heat shock, 4-day adult
5
Cadmium 50 mM 6 hrs, larvae L3
3
Cadmium 50 mM 12 hrs, larvae L3
4
Cadmium 50 mM 48 hrs, 4-day adult
6
Cadmium 100 mM 48 hrs, 4-day adult
9
Copper 0.5 mM 12 hrs, larvae L3
3
Copper 15 mM 48 hrs, 4-day adult
3
Zinc 5 mM 12 hrs, larvae L3
3
Zinc 4.5 mM 48 hrs, 4-day adult
5
Ethanol 2.5% 3 hrs, larvae L3
12
Ethanol 5% 3 hrs, larvae L3
3
Ethanol 10% 3 hrs, larvae L3
2
Caffeine 1.5 mg/ml 4 hrs, larvae L3
1
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
8
Caffeine 25 mg/ml 48 hrs, 4-day adult
4
Paraquat 5 mM 48 hrs, 4-day adult
13
Paraquat 10 mM 48 hrs, 4-day adult
6
Rotenone 2 μg 12 hrs, larvae L3
3
Rotenone 8 μg 12 hrs, larvae L3
1
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
7
cold shock, 4-day adult
3
heat shock, 4-day adult
5
Cadmium 50 mM 6 hrs, larvae L3
3
Cadmium 50 mM 12 hrs, larvae L3
4
Cadmium 50 mM 48 hrs, 4-day adult
6
Cadmium 100 mM 48 hrs, 4-day adult
9
Copper 0.5 mM 12 hrs, larvae L3
3
Copper 15 mM 48 hrs, 4-day adult
3
Zinc 5 mM 12 hrs, larvae L3
3
Zinc 4.5 mM 48 hrs, 4-day adult
5
Ethanol 2.5% 3 hrs, larvae L3
12
Ethanol 5% 3 hrs, larvae L3
3
Ethanol 10% 3 hrs, larvae L3
2
Caffeine 1.5 mg/ml 4 hrs, larvae L3
1
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
8
Caffeine 25 mg/ml 48 hrs, 4-day adult
4
Paraquat 5 mM 48 hrs, 4-day adult
13
Paraquat 10 mM 48 hrs, 4-day adult
6
Rotenone 2 μg 12 hrs, larvae L3
3
Rotenone 8 μg 12 hrs, larvae L3
1
Expression Level Scale
Very low
Low
Moderate
log, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
7
cold shock, 4-day adult
3
heat shock, 4-day adult
5
Cadmium 50 mM 6 hrs, larvae L3
3
Cadmium 50 mM 12 hrs, larvae L3
4
Cadmium 50 mM 48 hrs, 4-day adult
6
Cadmium 100 mM 48 hrs, 4-day adult
9
Copper 0.5 mM 12 hrs, larvae L3
3
Copper 15 mM 48 hrs, 4-day adult
3
Zinc 5 mM 12 hrs, larvae L3
3
Zinc 4.5 mM 48 hrs, 4-day adult
5
Ethanol 2.5% 3 hrs, larvae L3
12
Ethanol 5% 3 hrs, larvae L3
3
Ethanol 10% 3 hrs, larvae L3
2
Caffeine 1.5 mg/ml 4 hrs, larvae L3
1
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
8
Caffeine 25 mg/ml 48 hrs, 4-day adult
4
Paraquat 5 mM 48 hrs, 4-day adult
13
Paraquat 10 mM 48 hrs, 4-day adult
6
Rotenone 2 μg 12 hrs, larvae L3
3
Rotenone 8 μg 12 hrs, larvae L3
1
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
7
cold shock, 4-day adult
3
heat shock, 4-day adult
5
Cadmium 50 mM 6 hrs, larvae L3
3
Cadmium 50 mM 12 hrs, larvae L3
4
Cadmium 50 mM 48 hrs, 4-day adult
6
Cadmium 100 mM 48 hrs, 4-day adult
9
Copper 0.5 mM 12 hrs, larvae L3
3
Copper 15 mM 48 hrs, 4-day adult
3
Zinc 5 mM 12 hrs, larvae L3
3
Zinc 4.5 mM 48 hrs, 4-day adult
5
Ethanol 2.5% 3 hrs, larvae L3
12
Ethanol 5% 3 hrs, larvae L3
3
Ethanol 10% 3 hrs, larvae L3
2
Caffeine 1.5 mg/ml 4 hrs, larvae L3
1
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
8
Caffeine 25 mg/ml 48 hrs, 4-day adult
4
Paraquat 5 mM 48 hrs, 4-day adult
13
Paraquat 10 mM 48 hrs, 4-day adult
6
Rotenone 2 μg 12 hrs, larvae L3
3
Rotenone 8 μg 12 hrs, larvae L3
1
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
7
cold shock, 4-day adult
3
heat shock, 4-day adult
5
Cadmium 50 mM 6 hrs, larvae L3
3
Cadmium 50 mM 12 hrs, larvae L3
4
Cadmium 50 mM 48 hrs, 4-day adult
6
Cadmium 100 mM 48 hrs, 4-day adult
9
Copper 0.5 mM 12 hrs, larvae L3
3
Copper 15 mM 48 hrs, 4-day adult
3
Zinc 5 mM 12 hrs, larvae L3
3
Zinc 4.5 mM 48 hrs, 4-day adult
5
Ethanol 2.5% 3 hrs, larvae L3
12
Ethanol 5% 3 hrs, larvae L3
3
Ethanol 10% 3 hrs, larvae L3
2
Caffeine 1.5 mg/ml 4 hrs, larvae L3
1
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
8
Caffeine 25 mg/ml 48 hrs, 4-day adult
4
Paraquat 5 mM 48 hrs, 4-day adult
13
Paraquat 10 mM 48 hrs, 4-day adult
6
Rotenone 2 μg 12 hrs, larvae L3
3
Rotenone 8 μg 12 hrs, larvae L3
1
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Treatment
Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
External Data & Images
Linkouts
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
Alleles & Phenotypes Summary of Allele Phenotypes Classical Alleles ( 2 ) For All Classical Alleles Show Alleles Carried on Transgenic Constructs
( 3 ) For All Alleles Carried on Transgenic
Constructs Show Aneuploid Aberrations Not disrupted in Disrupted in (
Ashburner et al., 1999.10.12 ,
Ashburner et al., 1990 ,
Furukawa et al., 1992 ,
Roote, 1996.8 ,
Roote, 1997.8.13 ,
Roote, 2008.8.22 )
Duplicated in Not duplicated in Transgenic Constructs & Insertions
Transgenic Constructs Insertions Gene Ontology: Function, Process
& Cellular Component ( 3 unique terms ) Terms Based on
Experimental Evidence ( 0 terms ) Terms Based on Predictions or
Assertions ( 3 terms ) Molecular Function Biological Process Cellular Component Sequence Ontology: Class of Gene Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions Interacts with Please look at the allele data
for full details of the genetic interactions
External Data Linkouts
- A database of protein and genetic interactions
- A comprehensive database of gene and protein interactions.
Protein-protein interactions (PPI) from both known and predicted PPI data sets.
Orthologs
OrthoDB Orthologs (35)
- based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
OrthoDB orthology group searches
Drosophila inclusive ortholog search
Dipteran inclusive ortholog search
Insect inclusive ortholog search
Arthropod inclusive ortholog search
Metazoa inclusive ortholog search
Orthologs in Drosophila Species
(EOG6M6646 )
Drosophila melanogaster
fruit fly
Drosophila pseudoobscura pseudoobscura
Y
Orthologs in non-Drosophila Dipterans
(EOG69PB7S )
Aedes aegypti
Yellow fever mosquito
Anopheles gambiae
Malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects
(EOG61JX91 )
Apis mellifera
Western honey bee
Amel\GB55038
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008742
Acromyrmex echinatior
Panamanian leafcutter ant
Aech\AECH12122
Atta cephalotes
Leafcutter ant
Acep\ACEP10066
Camponotus floridanus
Florida carpenter ant
Cflo\CFLO20600
Harpegnathos saltator
Jerdons jumping ant
Hsal\HSAL13100
Linepithema humile
Argentine ant
Lhum\LH14070
Pogonomyrmex barbatus
Red harvester ant
Pbar\PB24477
Solenopsis invicta
Red fire ant
Sinv\SINV18422
Acyrthosiphon pisum
Pea aphid
Pediculus humanus
Human body louse
Tribolium castaneum
Red flour beetle
Orthologs in non-Insect Arthropods
(EOG66M92F )
Ixodes scapularis
Deer tick
Orthologs in non-Arthropod Metazoa
(EOG61GG0Q )
Strongylocentrotus purpuratus
Purple sea urchin
Rattus norvegicus
Norway rat
Human Orthologs (1)AAA Orthologs (11)
based on analysis using Dmel annotation version 4.3
Drosophila pseudoobscura pseudoobscura
Stocks & Reagents Stocks Listed in FlyBase ( 7 )Bloomington Harvard Kyoto VDRC Genomic Clones ( 1 )Please Note FlyBase no
longer curates genomic clone accessions so this list
may not be complete
cDNA Clones ( 3 )Please Note This section lists
cDNAs and ESTs that fall within the genomic extent
of the gene model, which may include cDNAs and ESTs
of genes within introns, or of overlapping genes.
Please see
GBrowse for alignment of the cDNAs and ESTs
to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones Other clones cDNA Clones, End Sequenced
(ESTs) BDGP DGC clones Other clones RNAi & Array Information Linkouts
- Results from RNAi screens.
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Other Information Discoverer Etymology Identification Relationship to Other Genes Source for database identity of Source for database merge of Source for merge of: l(2)35Cc CG15266
Additional comments No known alleles; existence inferred from lethality associated with
Df(2L)rd9 .
Other Comments Identification: predicted on the basis of the recessive lethality of
Df(2L)rd9 (
FBrf0051973 ). The existence of
l(2)35Cc has been confirmed by the complementation behaviour of deletions generated from
gft06430 by male recombination.
External Crossreferences & Linkouts
Sequence Crossreferences
- A searchable database of RefSeq genes.
Other Crossreferences
domains - A database of protein families, domains, and functional sites
Linkouts
- A database of protein and genetic interactions
- A comprehensive database of gene and protein interactions.
- Results from RNAi screens.
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
- Integrated genomics database for Drosophila, Anopheles, and C.elegans
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
Protein-protein interactions (PPI) from both known and predicted PPI data sets.
- Data generated by the modENCODE project.
Synonyms & Secondary IDs
( 7 )Reported As Symbol Synonym Name Synonym Secondary FlyBase
IDs References ( 30 )Generate a list of List References by type
Recent research papers (0)
All research papers listed in FlyBase were published before 2011
Recent reviews (0)
All reviews listed in FlyBase were published before 2011