l(2)34Da, l(2)br38, BG:DS07660.3
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.51
5.6 (longest cDNA)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\kuz using the Feature Mapper tool.
kuz expression is enriched in border follicle cells relative to other cells in the egg chamber.
kuz transcripts are expressed ubiquitously in the embryo and in imaginal discs. They are present at the highest levels in the ventral nerve cord, the morphogenetic furrow, and the developing ommatidia of the eye-antennal disc.
GBrowse - Visual display of RNA-Seq signalsView Dmel\kuz in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: kuz CG7147
Source for merge of: kuz l(2)c00136
Source for merge of: kuz GS11410
S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology.
kuz provides a proteolytic activity synthesised by axons and required by them to extend growth cones through the extracellular matrix.
Identified in an adult mosaic screen; required for lateral inhibition in proneural clusters.
The gene name "kuzbanian" recalls the physical appearance of the Koozbanians (an alien life-form version of the television characters the Muppets), who sported wildly uncontrollable hair sticking up on the tops of their heads, reminiscent of the striking supernumerary bristle phenotype in mosaics for a null kuz mutation.