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Gene Dmel\kuz

General Information
Symbol	Dmel\kuz	Species	D. melanogaster
Name	kuzbanian	Annotation symbol	CG7147
Feature type	protein_coding_gene	FlyBase ID	FBgn0259984
Gene Model Status	Current	Stock availability	31 publicly available
Also Known As	l(2)34Da, l(2)br38, BG:DS07660.3
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	34C4-34C6	Sequence location	2L:13,550,141..13,638,238 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene kuzbanian is referred to in FlyBase by the symbol Dmel\kuz (CG7147, FBgn0259984). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: metalloendopeptidase activity. There is experimental evidence for 12 unique biological process terms, many of which group under: system development; cardiovascular system development; localization; cellular component organization or biogenesis; multicellular organismal development; cellular component movement; cellular process; cardiac cell differentiation; biological regulation; primary metabolic process; hemopoietic or lymphoid organ development. 90 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; organ system; adult segment; thoracic segment; external compound sense organ; sense organ; multicellular structure; peripheral nervous system; embryonic dorsal vessel; embryonic pericardial cell; non-connected developing system; imaginal precursor. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Blood coagulation inhibitor, Disintegrin; Metallopeptidase, catalytic domain; Peptidase M12B, ADAM/reprolysin; Peptidase M12B, propeptide. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult Malpighian tubules, larval fat body, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1628215_s_at completely aligns to an exonic region common to each of the 5 FlyBase-annotated transcript isoforms of kuz. Gene sequence location is 2L:13550141..13638238.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Insertions Mi{MIC}kuz[MI03306] References Knowles-Barley, 2011.8.24, BrainTrap expression curation. Bellen, 2011.9.26, MI948.xml Alleles kuz[MI03306]
FB2012_01	Transgenic Constructs P{UAS-kuz.C} P{UAS-kuz.HA} Alleles kuz[420] kuz[Scer\UAS.cCa] kuz[112] kuz[Scer\UAS.T:Ivir\HA1] kuz[2583] References Egger et al., 2010, Development 137(18): 2981--2987 Sequence features BKN23747 HFA03555 Controlled Vocabulary Terms regulation of Roundabout signaling pathway axon guidance
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 34C4-34C6   Limits computationally determined from genome sequence between P{PZ}kuz03782&P{lacW}kuzk14817 and P{lacW}CG7364k07245
Experimentally Determined Cytological Location
Cytogenetic map Notes References 34C4-34C5   (determined by in situ hybridisation)   (Ashburner et al., 1999) 34C4-34C5   (determined by in situ hybridisation)   (Spradling et al., 1999) 34C4-34C5   (determined by in situ hybridisation)   (Rooke et al., 1996) 34C4-34C5     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\kuz for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Transposon inserted in intron
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) kuz-RA FBtr0080509  NM_057839   5603   1238 kuz-RB FBtr0080510  NM_165047   5476   1238 kuz-RC FBtr0100660  NM_001014481   4781   1090 kuz-RD FBtr0112886  NM_001103689   5530   1256 kuz-RF FBtr0301412  NM_001103690   4993   1219
Additional Transcript Data & Comments
Reported size (kB)	5.6 (longest cDNA) (Rooke et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein kuz-PA   FBpp0080087   136.4   1238   8.71     NP_477187   AAF53318 kuz-PB   FBpp0080088   136.4   1238   8.71     NP_723825   AAN10838 kuz-PC   FBpp0100122   121.2   1090   8.26     NP_001014481   AAX52664 kuz-PD   FBpp0111799   138.3   1256   8.66     NP_001097159   ABV53679 kuz-PF   FBpp0290626   135.3   1219   8.17     NP_001097160   ABV53680
Additional Polypeptide Data & Comments
Reported size (kDa)	1239 (aa) (Rooke et al., 1996)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase M12B, ADAM/reprolysin (IPR001590) Blood coagulation inhibitor, Disintegrin (IPR001762) Metallopeptidase, catalytic domain (IPR024079) Peptidase M12B, propeptide (IPR002870) MEROPS - An information resource for peptidases and the proteins that inhibit them • M12.211
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141521   AA201385   AA201945   AA540549   AE014134 AAF53318   AE014134 AAN10838   AE014134 AAX52664   AE014134 ABV53679   AE014134 ABV53680   AE003407 AAF44800   AI134237   AI542256   AQ025618   AQ026041   AQ026084   AQ026442   AQ073300   AY075364   BG633128   BG639404   BG640432   BI171395   BI215239   BI215515   BI237300   BI238737   BI242792   BI483487   BI483505   BI567989   BI568829   BI578975   BI580065   BI609954   BI614168   BI619573   BI631317   BI638091   BP541305   BP542275   BP547894   BP556629   BP556798   BP557924   BP557925   BT009943   BT031111   BT088937   CK135136   CK135150   CK135192   CK135207   CK135784   CK661894   CL610140   CO153682   CO153800   CO153891   CO154608   CO156273   CO179864   CO180028   CO186502   CO188071   CO268812   CO278703   CO282062   CO283473   CO287071   CO289734   CO293602   CO298724   CO299307   CO306000   CO309812   CO310409   CO319216   CO323895   CO329031   CO330478   CO334111   CO338026   CZ466227   CZ467288   CZ467785   CZ473221   CZ478761   CZ480691   CZ484926   CZ484927   CZ485236   CZ485237   CZ485252   CZ485253   CZ485762   CZ487305   CZ489018   CZ489019   EC055763   EC057366   EC062037   EC071350   EC073510   EC077572   EC086172   EC201301   EC206685   EC215506   EC217606   EC219164   EC219958   EC227897   EC236454   EC237978   EC241940   EC244508   EC246527   EC247507   EC260986   EC262075   EC262726   EC262888   EC263712   EC264366   EL884952   EL884953   EL885075   EL885076   EL885198   G01314   GH944988   GH953586   GH958462   GH973484   GH978009   U60591 AAC47275
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q94902 Q9VJW9 A8DZ03 Q59DZ3 A8DZ02
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous   (Sotillos et al., 1997) embryonic stage | late   epidermis   (Fambrough et al., 1996) presumptive embryonic/larval central nervous system   (Fambrough et al., 1996) third instar larval stage   ommatidial precursor cluster   (Sotillos et al., 1997) morphogenetic furrow   (Sotillos et al., 1997) imaginal disc | ubiquitous   (Sotillos et al., 1997) ventral nerve cord   (Sotillos et al., 1997) eye-antennal disc   (Sotillos et al., 1997)
Additional Descriptive Data
	The kuz transcript is expressed in all neurons of the embryonic central nervous system, and at lower levels in the epidermis. (Fambrough et al., 1996) kuz transcripts are expressed ubiquitously in the embryo and in imaginal discs. They are present at the highest levels in the ventral nerve cord, the morphogenetic furrow, and the developing ommatidia of the eye-antennal disc. (Sotillos et al., 1997)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0259984    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0259984 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0259984 expression level Developmental Stage   Expression Level embryo 00-02hr    2627 embryo 02-04hr    3513 embryo 04-06hr    3339 embryo 06-08hr    3463 embryo 08-10hr    3322 embryo 10-12hr    2592 embryo 12-14hr    2427 embryo 14-16hr    2431 embryo 16-18hr    1955 embryo 18-20hr    1459 embryo 20-22hr    1708 embryo 22-24hr    1508 larva L1    639 larva L2    361 larva L3 12hr old    334 larva L3 puffstage 1-2    299 larva L3 puffstage 3-6    1221 larva L3 puffstage 7-9    1846 white prepupae new    2882 white prepupae 12hr    1838 white prepupae 24hr    2472 pupae 2d postWPP    1830 pupae 3d postWPP    782 pupae 4d postWPP    530 adult male 01day    460 adult male 05day    457 adult male 30day    477 adult female 01day    1265 adult female 05day    1699 adult female 30day    1700 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2627) embryo 02-04hr  (3513) embryo 04-06hr  (3339) embryo 06-08hr  (3463) embryo 08-10hr  (3322) embryo 10-12hr  (2592) embryo 12-14hr  (2427) embryo 14-16hr  (2431) embryo 16-18hr  (1955) embryo 18-20hr  (1459) embryo 20-22hr  (1708) embryo 22-24hr  (1508) larva L1  (639) larva L2  (361) larva L3 12hr old  (334) larva L3 puffstage 1-2  (299) larva L3 puffstage 3-6  (1221) larva L3 puffstage 7-9  (1846) white prepupae new  (2882) white prepupae 12hr  (1838) white prepupae 24hr  (2472) pupae 2d postWPP  (1830) pupae 3d postWPP  (782) pupae 4d postWPP  (530) adult male 01day  (460) adult male 05day  (457) adult male 30day  (477) adult female 01day  (1265) adult female 05day  (1699) adult female 30day  (1700) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2627) embryo 02-04hr  (3513) embryo 04-06hr  (3339) embryo 06-08hr  (3463) embryo 08-10hr  (3322) embryo 10-12hr  (2592) embryo 12-14hr  (2427) embryo 14-16hr  (2431) embryo 16-18hr  (1955) embryo 18-20hr  1459 embryo 20-22hr  (1708) embryo 22-24hr  1508 larva L1    639 larva L2    361 larva L3 12hr old    334 larva L3 puffstage 1-2    299 larva L3 puffstage 3-6    1221 larva L3 puffstage 7-9  (1846) white prepupae new  (2882) white prepupae 12hr  (1838) white prepupae 24hr  (2472) pupae 2d postWPP  (1830) pupae 3d postWPP    782 pupae 4d postWPP    530 adult male 01day    460 adult male 05day    457 adult male 30day    477 adult female 01day    1265 adult female 05day  (1699) adult female 30day  (1700) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2627 embryo 02-04hr    3513 embryo 04-06hr    3339 embryo 06-08hr    3463 embryo 08-10hr    3322 embryo 10-12hr    2592 embryo 12-14hr    2427 embryo 14-16hr    2431 embryo 16-18hr    1955 embryo 18-20hr    1459 embryo 20-22hr    1708 embryo 22-24hr    1508 larva L1    639 larva L2    361 larva L3 12hr old    334 larva L3 puffstage 1-2    299 larva L3 puffstage 3-6    1221 larva L3 puffstage 7-9    1846 white prepupae new    2882 white prepupae 12hr    1838 white prepupae 24hr    2472 pupae 2d postWPP    1830 pupae 3d postWPP    782 pupae 4d postWPP    530 adult male 01day    460 adult male 05day    457 adult male 30day    477 adult female 01day    1265 adult female 05day    1699 adult female 30day    1700 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2627 embryo 02-04hr    3513 embryo 04-06hr    3339 embryo 06-08hr    3463 embryo 08-10hr    3322 embryo 10-12hr    2592 embryo 12-14hr    2427 embryo 14-16hr    2431 embryo 16-18hr    1955 embryo 18-20hr    1459 embryo 20-22hr    1708 embryo 22-24hr    1508 larva L1    639 larva L2    361 larva L3 12hr old    334 larva L3 puffstage 1-2    299 larva L3 puffstage 3-6    1221 larva L3 puffstage 7-9    1846 white prepupae new    2882 white prepupae 12hr    1838 white prepupae 24hr    2472 pupae 2d postWPP    1830 pupae 3d postWPP    782 pupae 4d postWPP    530 adult male 01day    460 adult male 05day    457 adult male 30day    477 adult female 01day    1265 adult female 05day    1699 adult female 30day    1700 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0259984 expression level Developmental Stage   Expression Level embryo 00-02hr    2627 embryo 02-04hr    3513 embryo 04-06hr    3339 embryo 06-08hr    3463 embryo 08-10hr    3322 embryo 10-12hr    2592 embryo 12-14hr    2427 embryo 14-16hr    2431 embryo 16-18hr    1955 embryo 18-20hr    1459 embryo 20-22hr    1708 embryo 22-24hr    1508 larva L1    639 larva L2    361 larva L3 12hr old    334 larva L3 puffstage 1-2    299 larva L3 puffstage 3-6    1221 larva L3 puffstage 7-9    1846 white prepupae new    2882 white prepupae 12hr    1838 white prepupae 24hr    2472 pupae 2d postWPP    1830 pupae 3d postWPP    782 pupae 4d postWPP    530 adult male 01day    460 adult male 05day    457 adult male 30day    477 adult female 01day    1265 adult female 05day    1699 adult female 30day    1700 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2627) embryo 02-04hr  (3513) embryo 04-06hr  (3339) embryo 06-08hr  (3463) embryo 08-10hr  (3322) embryo 10-12hr  (2592) embryo 12-14hr  (2427) embryo 14-16hr  (2431) embryo 16-18hr  (1955) embryo 18-20hr  (1459) embryo 20-22hr  (1708) embryo 22-24hr  (1508) larva L1  (639) larva L2  (361) larva L3 12hr old  (334) larva L3 puffstage 1-2  (299) larva L3 puffstage 3-6  (1221) larva L3 puffstage 7-9  (1846) white prepupae new  (2882) white prepupae 12hr  (1838) white prepupae 24hr  (2472) pupae 2d postWPP  (1830) pupae 3d postWPP  (782) pupae 4d postWPP  (530) adult male 01day  (460) adult male 05day  (457) adult male 30day  (477) adult female 01day  (1265) adult female 05day  (1699) adult female 30day  (1700) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2627) embryo 02-04hr  (3513) embryo 04-06hr  (3339) embryo 06-08hr  (3463) embryo 08-10hr  (3322) embryo 10-12hr  (2592) embryo 12-14hr  2427 embryo 14-16hr  2431 embryo 16-18hr  1955 embryo 18-20hr  1459 embryo 20-22hr  1708 embryo 22-24hr  1508 larva L1    639 larva L2    361 larva L3 12hr old    334 larva L3 puffstage 1-2    299 larva L3 puffstage 3-6    1221 larva L3 puffstage 7-9  1846 white prepupae new  (2882) white prepupae 12hr  1838 white prepupae 24hr  (2472) pupae 2d postWPP  1830 pupae 3d postWPP    782 pupae 4d postWPP    530 adult male 01day    460 adult male 05day    457 adult male 30day    477 adult female 01day    1265 adult female 05day  1699 adult female 30day  1700 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2627 embryo 02-04hr    3513 embryo 04-06hr    3339 embryo 06-08hr    3463 embryo 08-10hr    3322 embryo 10-12hr    2592 embryo 12-14hr    2427 embryo 14-16hr    2431 embryo 16-18hr    1955 embryo 18-20hr    1459 embryo 20-22hr    1708 embryo 22-24hr    1508 larva L1    639 larva L2    361 larva L3 12hr old    334 larva L3 puffstage 1-2    299 larva L3 puffstage 3-6    1221 larva L3 puffstage 7-9    1846 white prepupae new    2882 white prepupae 12hr    1838 white prepupae 24hr    2472 pupae 2d postWPP    1830 pupae 3d postWPP    782 pupae 4d postWPP    530 adult male 01day    460 adult male 05day    457 adult male 30day    477 adult female 01day    1265 adult female 05day    1699 adult female 30day    1700 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2627 embryo 02-04hr    3513 embryo 04-06hr    3339 embryo 06-08hr    3463 embryo 08-10hr    3322 embryo 10-12hr    2592 embryo 12-14hr    2427 embryo 14-16hr    2431 embryo 16-18hr    1955 embryo 18-20hr    1459 embryo 20-22hr    1708 embryo 22-24hr    1508 larva L1    639 larva L2    361 larva L3 12hr old    334 larva L3 puffstage 1-2    299 larva L3 puffstage 3-6    1221 larva L3 puffstage 7-9    1846 white prepupae new    2882 white prepupae 12hr    1838 white prepupae 24hr    2472 pupae 2d postWPP    1830 pupae 3d postWPP    782 pupae 4d postWPP    530 adult male 01day    460 adult male 05day    457 adult male 30day    477 adult female 01day    1265 adult female 05day    1699 adult female 30day    1700 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0259984    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0259984 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult Malpighian tubules, larval fat body, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0259984 expression level Tissue   Expression Level Larval Central Nervous System    310.75 Larval Midgut    61.5 Larval Hindgut    97.5 Larval Malpighian Tubules    91.1 Larval Fat Body    199.8 Larval Salivary Gland    28.6 Larval Trachea    92.8 Larval Carcass    38.7 Adult Head    32.4 Adult Eye    43.2 Adult Brain    140.9 Adult Thoracic-Abdominal Ganglion    107 Adult Crop    33.5 Adult Midgut    15.1 Adult Hindgut    61.5 Adult Malpighian Tubules    137.3 Adult Fat Body    42.5 Adult Salivary Gland no informative data Adult Heart    43.525 Adult VirginFemale Spermatheca    66 Adult InseminatedFemale Spermatheca    81.4 Adult Ovary    121.2 Adult Testis    13.1 Adult Male Accessory Gland    86.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    310.75 Larval Midgut    61.5 Larval Hindgut    97.5 Larval Malpighian Tubules    91.1 Larval Fat Body    199.8 Larval Salivary Gland    28.6 Larval Trachea    92.8 Larval Carcass    38.7 Adult Head    32.4 Adult Eye    43.2 Adult Brain    140.9 Adult Thoracic-Abdominal Ganglion    107 Adult Crop    33.5 Adult Midgut    15.1 Adult Hindgut    61.5 Adult Malpighian Tubules    137.3 Adult Fat Body    42.5 Adult Salivary Gland no informative data Adult Heart    43.525 Adult VirginFemale Spermatheca    66 Adult InseminatedFemale Spermatheca    81.4 Adult Ovary    121.2 Adult Testis    13.1 Adult Male Accessory Gland    86.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    310.75 Larval Midgut    61.5 Larval Hindgut    97.5 Larval Malpighian Tubules    91.1 Larval Fat Body    199.8 Larval Salivary Gland    28.6 Larval Trachea    92.8 Larval Carcass    38.7 Adult Head    32.4 Adult Eye    43.2 Adult Brain    140.9 Adult Thoracic-Abdominal Ganglion    107 Adult Crop    33.5 Adult Midgut    15.1 Adult Hindgut    61.5 Adult Malpighian Tubules    137.3 Adult Fat Body    42.5 Adult Salivary Gland no informative data Adult Heart    43.525 Adult VirginFemale Spermatheca    66 Adult InseminatedFemale Spermatheca    81.4 Adult Ovary    121.2 Adult Testis    13.1 Adult Male Accessory Gland    86.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    310.75 Larval Midgut    61.5 Larval Hindgut    97.5 Larval Malpighian Tubules    91.1 Larval Fat Body    199.8 Larval Salivary Gland    28.6 Larval Trachea    92.8 Larval Carcass    38.7 Adult Head    32.4 Adult Eye    43.2 Adult Brain    140.9 Adult Thoracic-Abdominal Ganglion    107 Adult Crop    33.5 Adult Midgut    15.1 Adult Hindgut    61.5 Adult Malpighian Tubules    137.3 Adult Fat Body    42.5 Adult Salivary Gland no informative data Adult Heart    43.525 Adult VirginFemale Spermatheca    66 Adult InseminatedFemale Spermatheca    81.4 Adult Ovary    121.2 Adult Testis    13.1 Adult Male Accessory Gland    86.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0259984 expression level Tissue   Expression Level Larval Central Nervous System    310.75 Larval Midgut    61.5 Larval Hindgut    97.5 Larval Malpighian Tubules    91.1 Larval Fat Body    199.8 Larval Salivary Gland    28.6 Larval Trachea    92.8 Larval Carcass    38.7 Adult Head    32.4 Adult Eye    43.2 Adult Brain    140.9 Adult Thoracic-Abdominal Ganglion    107 Adult Crop    33.5 Adult Midgut    15.1 Adult Hindgut    61.5 Adult Malpighian Tubules    137.3 Adult Fat Body    42.5 Adult Salivary Gland no informative data Adult Heart    43.525 Adult VirginFemale Spermatheca    66 Adult InseminatedFemale Spermatheca    81.4 Adult Ovary    121.2 Adult Testis    13.1 Adult Male Accessory Gland    86.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    310.75 Larval Midgut    61.5 Larval Hindgut    97.5 Larval Malpighian Tubules    91.1 Larval Fat Body    199.8 Larval Salivary Gland    28.6 Larval Trachea    92.8 Larval Carcass    38.7 Adult Head    32.4 Adult Eye    43.2 Adult Brain    140.9 Adult Thoracic-Abdominal Ganglion    107 Adult Crop    33.5 Adult Midgut    15.1 Adult Hindgut    61.5 Adult Malpighian Tubules    137.3 Adult Fat Body    42.5 Adult Salivary Gland no informative data Adult Heart    43.525 Adult VirginFemale Spermatheca    66 Adult InseminatedFemale Spermatheca    81.4 Adult Ovary    121.2 Adult Testis    13.1 Adult Male Accessory Gland    86.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    310.75 Larval Midgut    61.5 Larval Hindgut    97.5 Larval Malpighian Tubules    91.1 Larval Fat Body    199.8 Larval Salivary Gland    28.6 Larval Trachea    92.8 Larval Carcass    38.7 Adult Head    32.4 Adult Eye    43.2 Adult Brain    140.9 Adult Thoracic-Abdominal Ganglion    107 Adult Crop    33.5 Adult Midgut    15.1 Adult Hindgut    61.5 Adult Malpighian Tubules    137.3 Adult Fat Body    42.5 Adult Salivary Gland no informative data Adult Heart    43.525 Adult VirginFemale Spermatheca    66 Adult InseminatedFemale Spermatheca    81.4 Adult Ovary    121.2 Adult Testis    13.1 Adult Male Accessory Gland    86.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    310.75 Larval Midgut    61.5 Larval Hindgut    97.5 Larval Malpighian Tubules    91.1 Larval Fat Body    199.8 Larval Salivary Gland    28.6 Larval Trachea    92.8 Larval Carcass    38.7 Adult Head    32.4 Adult Eye    43.2 Adult Brain    140.9 Adult Thoracic-Abdominal Ganglion    107 Adult Crop    33.5 Adult Midgut    15.1 Adult Hindgut    61.5 Adult Malpighian Tubules    137.3 Adult Fat Body    42.5 Adult Salivary Gland no informative data Adult Heart    43.525 Adult VirginFemale Spermatheca    66 Adult InseminatedFemale Spermatheca    81.4 Adult Ovary    121.2 Adult Testis    13.1 Adult Male Accessory Gland    86.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    32.4   NA  Eye    43.2   NA  Brain    140.9   310.75  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    107   NA  Crop    33.5   61.5  Midgut    15.1   97.5  Hindgut    61.5   91.1  Malpighian Tubules    137.3   199.8  Fat Body    42.5   28.6  Salivary Gland    no informative data   NA  Heart    43.525   92.8  Trachea    NA   NA  VirginFemale Spermatheca    66   NA  InseminatedFemale Spermatheca    81.4   NA  Ovary    121.2   NA  Testis    13.1   NA  Male Accessory Gland    86.5   38.7  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_05
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259984
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal kuzCB02000 lethal | embryonic stage kuz3 kuzF2-16 kuzJ2-11 kuzP2-108 kuzR1-4 kuzS5-65 lethal | pharate adult stage | recessive kuz1405Rev11 lethal | recessive kuz3 kuzc00136 kuzH143 kuzk01403 kuzk07601 kuzk09934 kuzk11804 kuzk14701 semi-lethal kuz03782 semi-lethal | recessive kuz03782 viable kuz1405Rev4 kuz1405Rev23 kuzGSG4064-1 Other Phenotypes Allele behavior defective | somatic clone kuz1 neuroanatomy defective, with Scer\GAL4repo kuzDN.Scer\UAS neuroanatomy defective | dominant | embryonic stage 16 kuzH143 neuroanatomy defective | embryonic stage 16 kuze29-4 kuzunspecified neuroanatomy defective | embryonic stage 16, with Scer\GAL4ap-md544 kuzDN.Scer\UAS neuroanatomy defective | embryonic stage 16 | recessive kuzH143 visible kuze29-4 visible | dominant kuz8.DMR kuzDN.DMR kuzDN.GMR kuzDN.hs visible | recessive kuz1405Rev4 kuz1405Rev11 kuzk01405 visible | recessive | somatic clone kuzH143 kuzk01405 kuzk11804 Phenotype manifest in Allele border follicle cell | heat sensitive, with Scer\GAL4slbo.2.6 kuzDN.Scer\UAS commissure kuzunspecified dorsal mesothorax kuzk01405 embryonic dorsal vessel, with Scer\GAL4twi.PG kuzDN.Scer\UAS embryonic heart cardioblast kuze29-4 embryonic heart cardioblast | supernumerary kuz3 kuzF2-16 kuzJ2-11 kuzP2-108 kuzR1-4 kuzS5-65 kuze29-4 embryonic heart cardioblast | supernumerary, with Scer\GAL4twi.PG kuzDN.Scer\UAS embryonic pericardial cell kuzR1-4 embryonic pericardial cell, with Scer\GAL4twi.PG kuzDN.Scer\UAS embryonic somatic muscle, with Scer\GAL4sim.PS kuzDN.Scer\UAS embryonic somatic muscle, with Scer\GAL4twi.PG kuzDN.Scer\UAS eye kuzDN.GMR kuzk01405 eye, with Scer\GAL432B kuzDN.Scer\UAS eye disc | somatic clone kuz40-19 eye photoreceptor cell kuzDN.ro.hs haltere kuzk01405 imaginal disc kuzk01403 kuzk01405 kuzk11804 leg kuzk01405 longitudinal connective kuzunspecified longitudinal connective, with Scer\GAL4elav-C155 kuzDN.Scer\UAS longitudinal connective, with Scer\GAL4sim.PS kuzDN.Scer\UAS longitudinal connective | embryonic stage 16 kuzH143 kuze29-4 kuzunspecified longitudinal connective | embryonic stage 16, with Scer\GAL4ap-md544 kuzDN.Scer\UAS lymph gland primordium kuzR1-4 macrochaeta kuzBG01426 kuzk01405 macrochaeta | somatic clone kuz1 kuzH143 microchaeta kuzk01405 microchaeta | ectopic kuzDN.hs microchaeta | somatic clone kuzH143 kuzk11804 midline crossing tract | embryonic stage 16 kuzH143 kuze29-4 kuzunspecified midline crossing tract | embryonic stage 16, with Scer\GAL4ap-md544 kuzDN.Scer\UAS nervous system kuze29-4 neuron & eye | somatic clone kuzES24 neuron | P-stage kuzk01405 ommatidium | somatic clone kuz1 peripheral glial cell, with Scer\GAL4repo kuzDN.Scer\UAS presumptive embryonic/larval central nervous system, with Scer\GAL4sim.PS kuzDN.Scer\UAS presumptive embryonic/larval central nervous system | germline clone kuze29-4 scutum & macrochaeta kuz8.DMR kuzDN.DMR kuzDN.hs kuze29-4 scutum & macrochaeta, with Scer\GAL432B kuzDN.Scer\UAS scutum & macrochaeta | somatic clone kuz1 scutum & microchaeta kuzDN.hs sense organ kuzk01405 tarsal segment kuzk01405 ventral nerve cord commissure kuzunspecified wing kuz1405Rev11 kuz1405Rev4 kuz8.DMR kuzDN.DMR kuze29-4 kuzk01405 wing, with Scer\GAL432B kuzDN.Scer\UAS wing margin | somatic clone kuzH143 wing sensillum | somatic clone kuzk01405 wing vein, with Scer\GAL432B kuzDN.Scer\UAS wing vein | somatic clone kuzH143 kuzk01405
Classical Alleles ( 62 )
For All Classical Alleles Show
Allele of kuz Class Mutagen Stocks Known lesion kuz3 amorphic allele - genetic evidence 2 -- kuze29-4 amorphic allele - genetic evidence, loss of function allele P-element activity 2 Yes kuzEY03488 P-element activity 2 -- kuzk01403 hypomorphic allele - genetic evidence P-element activity 2 Yes kuzc00136 piggyBac transposase 1 -- kuzc01595 piggyBac transposase 1 -- kuzc02227 piggyBac transposase 1 -- kuzd03181 P-element activity 1 -- kuze00930 piggyBac transposase 1 -- kuze02921 piggyBac transposase 1 -- kuzf02299 1 -- kuzf02415 piggyBac transposase 1 -- kuzf02694 piggyBac transposase 1 -- kuzf02704 piggyBac transposase 1 -- kuzf04748 piggyBac transposase 1 -- kuzf05628a 1 -- kuzk07601 hypomorphic allele - genetic evidence P-element activity 1 Yes kuzk09934 P-element activity 1 -- kuzk11804 hypomorphic allele - genetic evidence P-element activity 1 Yes kuzk12004 P-element activity 1 -- kuzMB03175 1 -- kuzMI03306 1 -- kuzF2-16 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- kuzJ2-11 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- kuzP2-108 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- kuzR1-4 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes kuzS5-65 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- kuz03782 hypomorphic allele - genetic evidence P-element activity 0 -- kuz112 0 -- kuz1405Rev11 P-element activity 0 Yes kuz1405Rev23 P-element activity 0 Yes kuz1405Rev4 P-element activity 0 Yes kuz1 0 Yes kuz2583 0 -- kuz2 0 -- kuz40-19 ethyl methanesulfonate 0 -- kuz420 0 -- kuzBG01426 P-element activity 0 Yes kuzCB02000 P-element activity 0 Yes kuzCPTI000031 piggyBac transposase 0 Yes kuzCPTI001303 piggyBac transposase 0 Yes kuzES24 0 -- kuzf03218 piggyBac transposase 0 -- kuzf06330 piggyBac transposase 0 -- kuzf06682 0 -- kuzF363 natural population 0 Yes kuzGS11410 0 -- kuzGSG4064-1 0 Yes kuzH143 0 -- kuzIK5 0 -- kuzk01405 P-element activity 0 Yes kuzk14701 hypomorphic allele - genetic evidence P-element activity 0 Yes kuzk14817 P-element activity 0 -- kuzmr28 hypomorphic allele - genetic evidence Delta2-3 0 -- kuzmr9 hypomorphic allele - genetic evidence Delta2-3 mitotic recombination 0 -- kuzrK028 P-element activity 0 Yes kuzTE34Ca-GV1 0 -- kuzTE34Cc-GV1 0 -- kuzTE34Cc-GV2 0 -- kuzTE34Cc-SV1 0 -- kuzunspecified 0 -- kuzZ524 0 --
Alleles Carried on Transgenic Constructs ( 28 )
For All Alleles Carried on Transgenic Constructs Show
Allele of kuz Class Mutagen Stocks Known lesion kuzDN.Scer\UAS in vitro construct - regulatory fusion 2 Yes kuzScer\UAS.cFa in vitro construct - regulatory fusion 2 Yes kuzKK103555 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes kuz1.DMR in vitro construct - regulatory fusion 0 Yes kuz1.GMR in vitro construct - regulatory fusion 0 Yes kuz2.GMR in vitro construct - deletion 0 Yes kuz3.GMR in vitro construct - deletion 0 Yes kuz4.DMR in vitro construct - deletion 0 Yes kuz4.GMR in vitro construct - deletion 0 Yes kuz5.DMR in vitro construct - deletion 0 Yes kuz6.DMR in vitro construct - deletion 0 Yes kuz8.DMR in vitro construct 0 Yes kuz9.DMR in vitro construct 0 Yes kuzAct5C.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 -- kuzDN.DMR in vitro construct - deletion 0 Yes kuzDN.GMR in vitro construct - deletion 0 Yes kuzDN.hs.Q in vitro construct - regulatory fusion 0 Yes kuzDN.hs in vitro construct - regulatory fusion 0 Yes kuzDN.MtnA in vitro construct - regulatory fusion 0 Yes kuzDN.ro.hs in vitro construct - regulatory fusion 0 Yes kuzdsRNA.cBa in vitro construct - RNAi 0 Yes kuzdsRNA.cLb in vitro construct - RNAi 0 Yes kuzdsRNA.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes kuzGD1127 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes kuzhs.PQ in vitro construct - regulatory fusion 0 Yes kuzMtnA.PP in vitro construct - regulatory fusion 0 Yes kuzScer\UAS.cCa in vitro construct - regulatory fusion 0 Yes kuzScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Duplicated in	Dp(2;3)17 (Roote, 1996.8, Roote, 1997.6.3) Ts(YLt;2Lt)A80+Ts(YLt;2Rt)G74 (Roote et al., 1996)
Disrupted in	Df(2L)b80e3 (Roote et al., 1996) Df(2L)b80f1 (Roote, 1995.3.27) Df(2L)b80k (Roote, 1995.3.27, Roote, 1996.8) Df(2L)b84a2 (Roote et al., 1996) Df(2L)b84a7 (Roote et al., 1996) Df(2L)b84h14 (Roote, 1995.3.27, Alexandrova et al., 1996) Df(2L)b85f2 (Alexandrova et al., 1996) Df(2L)b87e25 (Ashraf et al., 1999, Iyengar et al., 1999, Thibault et al., 2004, Roote, 1995.3.27, Roote, 1996.8) Df(2L)b88b15 (Roote, 1996.8) Df(2L)b88c25 (Roote, 2000.6.5, Roote, 2000.7.3, Roote et al., 1996, Alexandrova et al., 1996, Roote, 1996.8) Df(2L)b88c58 (Alexandrov and Alexandrova, 1991, Roote, 1996.8) Df(2L)b88c75 (Roote, 1995.3.27, Alexandrova et al., 1996, Roote, 1996.8) Df(2L)b88f43 (Roote, 1995.3.27, Roote, 1996.8) Df(2L)b88h49 (Roote et al., 1996, Roote, 1996.8, Sotillos et al., 1997) Df(2L)b89e64b (Roote, 2000.6.5) Df(2L)b89e68 (Roote, 2000.6.5) Df(2L)b89e72 (Roote, 2000.6.5) Df(2L)b89e80a (Roote, 2000.6.5, Roote, 2000.7.3) Df(2L)b89e88a (Roote, 2000.6.5) Df(2L)b89e88b (Roote, 2000.6.5) Df(2L)b89e96 (Roote, 2000.6.5) Df(2L)BSC147 (Christensen and Cook, 2006.3.8) Df(2L)BSC691 (Christensen et al., 2008.12.28) Df(2L)Exel7058 (Ryder, 2004.4.26) Df(2L)k07245Lk05605R-mr1 (Roote, 2000.6.13) Df(2L)k07245Lk05605R-mr3 (Roote, 2000.6.13) Df(2L)k07245-rv1 (Roote, 2000.6.13) Df(2L)PZ07130-mr1 (Roote, 2000.6.13) In(2L)b82a1 (Roote, 1995.3.27) In(2L)b88e16 (Roote, 2000.6.5) Tp(1;2)TE34Cc (Gubb et al., 1986) Tp(2;Y)b88b15 (Roote, 1995.3.27, Alexandrova et al., 1996) Ts(YSt;2Lt)G74+Ts(YSt;2Rt)A80 (Roote, 1995.3.27, Roote et al., 1996)
Not disrupted in	Df(2L)64j (Iyengar et al., 1999, Roote, 2000.7.3) Df(2L)A47 (Fossett et al., 1994) Df(2L)A48 (Fossett et al., 1994) Df(2L)A63 (Fossett et al., 1994) Df(2L)A72 (Fossett et al., 1994) Df(2L)A178 (Fossett et al., 1994) Df(2L)A215 (Fossett et al., 1994) Df(2L)A217 (Fossett et al., 1994) Df(2L)A220 (Fossett et al., 1994) Df(2L)A245 (Fossett et al., 1994) Df(2L)A246 (Fossett et al., 1994) Df(2L)A264 (Fossett et al., 1994) Df(2L)A266 (Fossett et al., 1994) Df(2L)A267 (Fossett et al., 1994) Df(2L)A337 (Fossett et al., 1994) Df(2L)A376 (Fossett et al., 1994) Df(2L)A379 (Fossett et al., 1994) Df(2L)A400 (Fossett et al., 1994) Df(2L)A445 (Fossett et al., 1994) Df(2L)Adh-nBR100 (Fossett et al., 1994) Df(2L)Adh-nBR101 (Fossett et al., 1994) Df(2L)Adh-nBR102 (Fossett et al., 1994) Df(2L)Adh-nBR103 (Fossett et al., 1994) Df(2L)Adh-nBR105 (Fossett et al., 1994) Df(2L)Adh-nBR106 (Fossett et al., 1994) Df(2L)Adh-nBR107 (Fossett et al., 1994) Df(2L)Adh-nBR117 (Fossett et al., 1994) Df(2L)Adh-nBR118 (Fossett et al., 1994) Df(2L)Adh-nBR119 (Fossett et al., 1994) Df(2L)Adh-nBR120 (Fossett et al., 1994) Df(2L)Adh-nBR121 (Fossett et al., 1994) Df(2L)Adh-nBR122 (Fossett et al., 1994) Df(2L)Adh-nBR125 (Fossett et al., 1994) Df(2L)Adh-nBR126 (Fossett et al., 1994) Df(2L)Adh-nBR127 (Fossett et al., 1994) Df(2L)Adh-nBR128 (Fossett et al., 1994) Df(2L)Adh-nBR129 (Fossett et al., 1994) Df(2L)Adh-nBR130 (Fossett et al., 1994, Roote, 1996.1.11, Roote, 1996.8) Df(2L)Adh-nBR131 (Fossett et al., 1994) Df(2L)b75 (Roote, 2000.7.3) Df(2L)b77c (Roote, 2000.7.3) Df(2L)b78j (Roote, 2000.7.3) Df(2L)b79b4 (Roote, 2000.7.3) Df(2L)b80c1 (Iyengar et al., 1999) Df(2L)b80k (Roote, 2000.7.3) Df(2L)b81l42 (Roote, 2000.7.3) Df(2L)b83d29a (Roote, 2000.7.3) Df(2L)b83l1 (Roote, 2000.7.3) Df(2L)b84a4 (Roote, 2000.7.3, Bonfini et al., 1992) Df(2L)b84a8 (Roote, 2000.7.3) Df(2L)b84a9 (Iyengar et al., 1999) Df(2L)b84h1 (Bonfini et al., 1992) Df(2L)b84h50 (Roote, 1996.8) Df(2L)b85b1 (Roote, 2000.7.3) Df(2L)b85f1 (Roote, 2000.7.3) Df(2L)b88f40 (Roote, 2000.7.3) Df(2L)b88g83 (Roote, 2000.7.3) Df(2L)b88g96 (Roote, 1996.8) Df(2L)b89e68 (Roote, 2000.7.3) Df(2L)b89e72 (Roote, 2000.7.3) Df(2L)b91l5 (Roote, 2000.7.3) Df(2L)k07245-mr2 (Roote, 2000.6.13) Df(2L)k07245-mr11 (Roote, 2000.6.13) Df(2L)k07245-mr31 (Roote, 2000.6.13) Df(2L)k07245-mr32 (Roote, 2000.6.13) Df(2L)Sco7 (Bonfini et al., 1992) Df(2L)TE35B-1 (Gubb et al., 1985) Df(2L)TE35B-2 (Gubb et al., 1985) Df(2L)TE35B-3 (Gubb et al., 1985) Df(2L)TE35B-4 (Gubb et al., 1985) Df(2L)TE35B-5 (Gubb et al., 1985) Df(2L)TE35B-6 (Gubb et al., 1985) Df(2L)TE35B-7 (Gubb et al., 1985) Df(2L)TE35B-8 (Gubb et al., 1985) Df(2L)TE35B-9 (Gubb et al., 1985) Df(2L)TE35B-10 (Gubb et al., 1985) Df(2L)TE35B-11 (Gubb et al., 1985) Df(2L)TE35B-12 (Gubb et al., 1985) Df(2L)TE35B-15 (Gubb et al., 1985) Df(2L)TE35BC-1 (Gubb et al., 1984) Df(2L)TE35BC-3 (Gubb et al., 1984) Df(2L)TE35BC-4 (Gubb et al., 1984) Df(2L)TE35BC-6 (Gubb et al., 1984) Df(2L)TE35BC-7 (Gubb et al., 1984) Df(2L)TE35BC-8 (Gubb et al., 1984) Df(2L)TE35BC-23 (Gubb et al., 1984) Df(2L)TE35BC-24 (Gubb et al., 1984) Df(2L)TE35BC-28 (Gubb et al., 1984) Df(2L)TE35BC-29 (Gubb et al., 1984) Df(2L)TE35BC-31 (Gubb et al., 1984) Df(2L)TE35BC-34 (Gubb et al., 1984) Df(2L)TE35BC-35 (Gubb et al., 1984) In(2L)TE35B-13 (Gubb et al., 1985) In(2LR)b71k1A (Bonfini et al., 1992) In(2LR)b81a2 (Bonfini et al., 1992) In(2LR)b81a2LDTD43R (Bonfini et al., 1992) Tp(2;2)A446 (Fossett et al., 1994)
Partially disrupted in	Df(2L)k07245-mr9 (Roote, 2000.6.13) Df(2L)k07245-mr28 (Roote, 2000.6.13)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1127} NA P{KK103555} NA P{UAS-kuz.C} NA P{UAS-kuz.DN} NA P{UAS-kuz.dsRNA.S} NA P{UAS-kuz.F} NA P{UAS-kuz.HA} NA heat-shock construct P{hs/KUZDN} NA P{rough/KUZDN} NA characterization construct P{kuz-DMR.1} NA P{kuz-DMR.4} NA P{kuz-DMR.5} NA P{kuz-DMR.6} NA P{kuz-DMR.8} NA P{kuz-DMR.9} NA P{kuz-DMR.DN} NA P{kuz-GMR.1} NA P{kuz-GMR.2} NA P{kuz-GMR.3} NA P{kuz-GMR.4} NA P{kuz-GMR.DN} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}kuzk01403 No P{lacW}kuzk01405 No P{lacW}kuzk07601 No P{lacW}kuzk09934 No P{lacW}kuzk11804 No P{lacW}kuzk12004 No P{lacW}kuzk14701 No P{lacW}kuzk14817 No P{lacW}l(2)SH0837SH0837 No P{PZ}kuz03782 No P{PZ}kuzrK028 No insertion of mobile activating element P{EPgy2}kuzEY03488 NA P{GSV6}kuzGS11410 NA P{XP}kuzd03181 NA miscellaneous insertions Mi{MIC}kuzMI03306 NA P{?lacW}kuz1405Rev4 NA P{?lacW}kuz1405Rev11 NA P{?lacW}kuz1405Rev23 NA P{GT1}kuzBG01426 NA P{PTT-GB}kuzCB02000 NA P{Switch2}kuzGSG4064-1 NA P{UASp-YFP.Rab10}13 NA PBac{602.P.SVS-1}kuzCPTI000031 NA PBac{681.P.FSVS-1}kuzCPTI001303 NA PBac{PB}kuzc00136 NA PBac{PB}kuzc01595 NA PBac{PB}kuzc02227 NA PBac{RB}kuze00930 NA PBac{RB}kuze02921 NA PBac{WH}kuzf02299 NA PBac{WH}kuzf02415 NA PBac{WH}kuzf02694 NA PBac{WH}kuzf02704 NA PBac{WH}kuzf03218 NA PBac{WH}kuzf04748 NA PBac{WH}kuzf05628a NA PBac{WH}kuzf06330 NA PBac{WH}kuzf06682 NA insertion of enhancer trap binary system Mi{ET1}kuzMB03175 No
Gene Ontology: Function, Process & Cellular Component ( 18 unique terms )
Terms Based on Experimental Evidence ( 13 terms )
Molecular Function
CV term Evidence References
metalloendopeptidase activity inferred from genetic interaction with N AND inferred from sequence or structural similarity with mouse Adam10 (Pan and Rubin, 1997)
Biological Process
CV term Evidence References
axon guidance inferred from mutant phenotype (Coleman et al., 2010) border follicle cell migration inferred from mutant phenotype (Wang et al., 2007) cardiac cell differentiation inferred from mutant phenotype (Albrecht et al., 2006) glial cell migration inferred from mutant phenotype (Edenfeld et al., 2007) heart morphogenesis inferred from mutant phenotype (Albrecht et al., 2006) lymph gland development inferred from mutant phenotype (Albrecht et al., 2006) muscle tissue development inferred from mutant phenotype (Albrecht et al., 2006) Notch receptor processing inferred from genetic interaction with H AND inferred from genetic interaction with N AND inferred from genetic interaction with Ser (Sotillos et al., 1997) pericardial cell differentiation inferred from mutant phenotype (Albrecht et al., 2006) phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006) regulation of Roundabout signaling pathway inferred from genetic interaction with robo (Coleman et al., 2010) skeletal muscle tissue development inferred from mutant phenotype (Albrecht et al., 2006)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
zinc ion binding inferred from electronic annotation with InterPro:IPR002870 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
central nervous system development traceable author statement (McFarlane, 2003) Notch signaling pathway traceable author statement (Kadesch, 2000) proteolysis inferred from electronic annotation with InterPro:IPR001590, InterPro:IPR002870 (FlyBase Curators et al., 2004-) regulation of axon extension traceable author statement (McFarlane, 2003)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene (Laviolette et al., 2005) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions kuz allele Gene References kuz1405Rev4 N (Sotillos et al., 1997) Ser (Sotillos et al., 1997) kuz1405Rev11 N (Sotillos et al., 1997) kuzDN.DMR N (Pan and Rubin, 1997) kuze29-4 N (Lieber et al., 2002) kuzk01405 E(spl) (Sotillos et al., 1997) H (Sotillos et al., 1997) N (Sotillos et al., 1997) Ser (Sotillos et al., 1997) kuzunspecified sli (Schimmelpfeng et al., 2001) unspecified Dl (Qi et al., 1999) Hs3st-B (Kamimura et al., 2004) Nsf2 (Laviolette et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60806 DroID - A comprehensive database of gene and protein interactions. • FBgn0259984 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34772
Orthologs
Genome-wide drosophilid orthologs	Dana\GF22940 Dere\GG23868 Dgri\GH12996 Dmoj\GI17667 Dper\GL26072 Dpse\GA20137 Dsec\GM10663 Dsim\GD23911 Dvir\GJ17864 Dwil\GK24503 Dyak\GE18670
Curated drosophilid orthologs	Dpse\GA20137   Dpse\kuz (Burnette, 2005)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL002663-PA Aedes aegypti (mosquito) AGAP008790-PA Anopheles gambiae (mosquito) XP_393114.3 Apis mellifera (honey bee) 247442 Branchiostoma floridae (lancelet) XP_001902618.1 Brugia malayi (roundworm nematode) BGIBMGA002480-PA Bombyx mori (silk worm) ENSBTAP00000042110 Bos taurus (bovine) CN03666 Caenorhabditis brenneri (small nematode) CN07784 Caenorhabditis brenneri (small nematode) CBP33382 Caenorhabditis briggsae (nematode) CE15751 Caenorhabditis elegans (worm) ENSCAFP00000024372 Canis familiaris (dog) ENSCINP00000019328 Ciona intestinalis (sea squirt) JA11698 Caenorhabditis japonica (nematode) CPIJ016694 Culex pipens (mosquito) ENSCPOP00000009443 Cavia porcellus (guinea pig) RP47424 Caenorhabditis remanei (nematode) ENSCSAVP00000000754 Ciona savignyi (sedentary tunicate) 166274 Capitella spl (polychaete worm) 310789 Daphnia pulex (daphnia) ENSDARP00000090413 Danio rerio (zebra fish) ENSECAP00000006414 Equus caballus (horse) ENSGACP00000008119 Gymnopilus aculeatus (mushroom) ENSGALP00000006687 Gallus gallus (chicken) 191436 Hypsipyla robusta (cedar shoot borer) ENSP00000260408 Homo sapiens (human) ISCW014660-PA Ixodes scapularis (deer tick) 138941 Lottia gigantea (owl limpet) ENSMODP00000010872 Monodelphis domestica (gray opossum) ENSMMUP00000023035 Macaca mulatta (rhesus monkey) ENSMUSP00000063839 Mus musculus (house mouse) XP_001601668.1 Nasonia vitripennis (wasp) ENSOANP00000014565 Ornithorynchus anatinus (platypus) ENSORLP00000006688 Oryzias latipes (japanese killifish) PHUM003295-PA Pediculus humanus (human body louse) PP17101 Pristionchus pacificus (nematode) ENSPPYP00000007386 Pongo pygmaeus (orangutan) ENSPTRP00000012167 Pan troglodytes (chimpanzee) Smp_145900 Schistosoma mansoni (trematode parasite) XP_001177064.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001188446.1 Strongylocentrotus purpuratus (purple sea urchin) 19172 Trichoplax adhaerens (metazoa) XP_971185.2 Tribolium castaneum (red flour beetle) ENSTNIP00000016702 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000021423 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000023740 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV13865 LH21800 ISCW014660 FBgn0236071 FBgn0226463 FBgn0205032 FBgn0195279 FBgn0187148 FBgn0165609 JGI_V11_310789 FBgn0080133 FBgn0163654 FBgn0140408 FBgn0120474 FBgn0116007 FBgn0099934 CPIJ016694 BGIBMGA002480 GB13192 AGAP008790 AAEL002663 PB21316 PHUM259590 GLEAN_01512
Stocks & Reagents
Stocks Listed in FlyBase ( 31 )
Bloomington	5804 kuze29-4/CyO
Harvard	- P{XP}kuzd03181 - PBac{PB}kuzc00136 - PBac{PB}kuzc01595 - PBac{PB}kuzc02227 - PBac{RB}kuze00930 - PBac{RB}kuze02921 - PBac{WH}kuzf02299 - PBac{WH}kuzf02415 - PBac{WH}kuzf02694
Kyoto	108432 kuze29-4/CyO
VDRC	v107036 P{KK103555}VIE-260B
	More stocks available...
Genomic Clones ( 2 )
	BACR20D18 BACR48E02 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 99 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM08552 SD03071
Other clones	IP16056 MIP12927
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH11638 GH20629 LD04086 LD04356 LD20268 LP08744 LP21681 RE13157 RE21582 RE22037 RE33509 RE35258 RE40222 RE66389 RE66413 RE72932 RE74193 RH01127 RH14812 RH25161 RH26018 RH29582 RH30388 RH39312 RH43478 RH50636 RH60871 RH67933 SD08461 SD11448 SD20287
Other clones	18302 43952 44188 63241 64949 74250 78886 84195 147349 149569 164595 192450 287824 289031 291412 292542 299275 CK01.22A.B2 CK01.82B.E9 CK01.121B.E9 CK01.130A.H11 CK01897 EC00402 EC00802 EC055763 EK020337 EK037123 EK064819 EK071929 EK092817 EK131216 EK159442 EK163352 EK173657 EK175043 EK191835 EK203821 EK219405 EK221555 EK249961 EK276654 EK291910 EK295354 EK308926 EN02561 EN02841 EN03031 EN04446 EN07710 EN15813 FGB001F02 FGC011B02 FGH121G11 FGM304F05 FGM305F01 FGM312A01 IP16156 IP16256 IP16356 RP004032918 RP004127659 RP004233778 RP004264579 RP004380746
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0259984 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34772
Antibody Information
Other Information
Discoverer
Etymology
	The gene name "kuzbanian" recalls the physical appearance of the Koozbanians (an alien life-form version of the television characters the Muppets), who sported wildly uncontrollable hair sticking up on the tops of their heads, reminiscent of the striking supernumerary bristle phenotype in mosaics for a null kuz mutation. (Rooke, 1997.11.3)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: kuz CG7147 (Guan, 1999.11)
Source for database merge of	Source for merge of: kuz GS11410 (FlyBase, 1996-) Source for merge of: kuz l(2)c00136 (Gene Disruption Project members and Exelixis, 2005)
Additional comments
Other Comments
	S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006) kuz can mediate S2 cleavage of N. (Lieber et al., 2002) The kuz metalloprotease is required for Dl ligand cleavage at the cell surface. (Qi et al., 1999) Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology. (Roch et al., 1998) A dominant negative form of kuz indicates that kuz is probably not involved in the release of the intracellular domain of Notch-1 protein during signalling. (Schroeter et al., 1998) kuz provides a proteolytic activity synthesised by axons and required by them to extend growth cones through the extracellular matrix. (Pan and Rubin, 1997) kuz is a component of the N signalling pathway and is involved in the activation of the N protein. (Sotillos et al., 1997) Lack of maternal kuz function does not contribute to the axon extension phenotype of kuz mutant embryos. (Fambrough et al., 1996) Identified in an adult mosaic screen; required for lateral inhibition in proneural clusters. (Rooke et al., 1996) Mosaic analysis indicates that kuz is required for cells to receive signals inhibiting the neural fate. Analyses further reveal that the development of a neuron requires a kuz-mediated positive signal from neighbouring cells. (Rooke et al., 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057839 NM_165047 NM_001014481 NM_001103689 NM_001103690 RefSeq (Proteins) • NP_477187 NP_723825 NP_001014481 NP_001097159 NP_001097160 DDBJ / EMBL / GenBank • AA201385 AA201945 AA540549 AAC47275 AAF44800 AAF53318 AAF53318.1 AAN10838 AAN10838.1 AAX52664 ABV53679 ABV53680 AE003407 AQ025618 AQ026041 AQ026084 AQ026442 AQ073300 CL610140 CZ466227 CZ467288 CZ467785 CZ473221 CZ478761 CZ480691 CZ484926 CZ484927 CZ485236 CZ485237 CZ485252 CZ485253 CZ485762 CZ487305 CZ489018 CZ489019 G01314 U60591 Entrez Gene - A searchable database of RefSeq genes. • 34772 UniProtKB/TrEMBL • A8DZ02 A8DZ03 Q9VJW9 Q59DZ3 Q94902
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidase M12B, ADAM/reprolysin (IPR001590) Blood coagulation inhibitor, Disintegrin (IPR001762) Metallopeptidase, catalytic domain (IPR024079) Peptidase M12B, propeptide (IPR002870) MEROPS - An information resource for peptidases and the proteins that inhibit them • M12.211
Linkouts
	BioGRID - A database of protein and genetic interactions • 60806 DroID - A comprehensive database of gene and protein interactions. • FBgn0259984 DRSC - Results from RNAi screens. • FBgn0259984 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259984 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0259984 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34772 InParanoid A subset of ortholog calls from InParanoid. • AAEL002663-PA Aedes aegypti (mosquito) AGAP008790-PA Anopheles gambiae (mosquito) XP_393114.3 Apis mellifera (honey bee) 247442 Branchiostoma floridae (lancelet) XP_001902618.1 Brugia malayi (roundworm nematode) BGIBMGA002480-PA Bombyx mori (silk worm) ENSBTAP00000042110 Bos taurus (bovine) CN03666 Caenorhabditis brenneri (small nematode) CN07784 Caenorhabditis brenneri (small nematode) CBP33382 Caenorhabditis briggsae (nematode) CE15751 Caenorhabditis elegans (worm) ENSCAFP00000024372 Canis familiaris (dog) ENSCINP00000019328 Ciona intestinalis (sea squirt) JA11698 Caenorhabditis japonica (nematode) CPIJ016694 Culex pipens (mosquito) ENSCPOP00000009443 Cavia porcellus (guinea pig) RP47424 Caenorhabditis remanei (nematode) ENSCSAVP00000000754 Ciona savignyi (sedentary tunicate) 166274 Capitella spl (polychaete worm) 310789 Daphnia pulex (daphnia) ENSDARP00000090413 Danio rerio (zebra fish) ENSECAP00000006414 Equus caballus (horse) ENSGACP00000008119 Gymnopilus aculeatus (mushroom) ENSGALP00000006687 Gallus gallus (chicken) 191436 Hypsipyla robusta (cedar shoot borer) ENSP00000260408 Homo sapiens (human) ISCW014660-PA Ixodes scapularis (deer tick) 138941 Lottia gigantea (owl limpet) ENSMODP00000010872 Monodelphis domestica (gray opossum) ENSMMUP00000023035 Macaca mulatta (rhesus monkey) ENSMUSP00000063839 Mus musculus (house mouse) XP_001601668.1 Nasonia vitripennis (wasp) ENSOANP00000014565 Ornithorynchus anatinus (platypus) ENSORLP00000006688 Oryzias latipes (japanese killifish) PHUM003295-PA Pediculus humanus (human body louse) PP17101 Pristionchus pacificus (nematode) ENSPPYP00000007386 Pongo pygmaeus (orangutan) ENSPTRP00000012167 Pan troglodytes (chimpanzee) Smp_145900 Schistosoma mansoni (trematode parasite) XP_001177064.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001188446.1 Strongylocentrotus purpuratus (purple sea urchin) 19172 Trichoplax adhaerens (metazoa) XP_971185.2 Tribolium castaneum (red flour beetle) ENSTNIP00000016702 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000021423 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000023740 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /neural/kuzban1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34772 modMine - Data generated by the modENCODE project. • FBgn0259984 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV13865 LH21800 ISCW014660 FBgn0236071 FBgn0226463 FBgn0205032 FBgn0195279 FBgn0187148 FBgn0165609 JGI_V11_310789 FBgn0080133 FBgn0163654 FBgn0140408 FBgn0120474 FBgn0116007 FBgn0099934 CPIJ016694 BGIBMGA002480 GB13192 AGAP008790 AAEL002663 PB21316 PHUM259590 GLEAN_01512
Synonyms & Secondary IDs ( 21 )
Reported As
Symbol Synonym	34Da (Bonfini et al., 1992) 11410 (Laviolette et al., 2005) ADAM10 (Krejcí et al., 2009) BG:DS07660.3 (Ashburner et al., 1999.10.12, Ashburner et al., 1999) br38 (Gubb et al., 1985) CG7147 (Metaxakis et al., 2005, Norga et al., 2003, Moorman et al., 2006, González et al., 2008, Keleman et al., 2009.8.5) CT22079 (Hynes and Zhao, 2000) GS11410   Kuz (Loewer et al., 2004, Prasad and Montell, 2007, González et al., 2008) kuz (Burnette, 2005, Koelzer and Klein, 2006, Kamimura et al., 2004, Kamimura et al., 2004, Edenfeld et al., 2007, Stroschein-Stevenson et al., 2006, Zhang et al., 2006, Buszczak et al., 2007, Acar et al., 2008, Meyer and Aberle, 2006, Zhang et al., 2007, Albrecht et al., 2006, Langdon et al., 2006, Zeitouni et al., 2007, Wang et al., 2007, Menut et al., 2007, Kankel et al., 2007, Christensen et al., 2008.12.28, González et al., 2008, Sellin et al., 2009, Becam and Milán, 2008, Krejcí et al., 2009, Carmine-Simmen et al., 2009, Zeitlinger et al., 2007, Udolph et al., 2009, Lake et al., 2009, Saj et al., 2010, Terriente-Félix et al., 2010, Coleman et al., 2010, Egger et al., 2010) l34Da (Fossett et al., 1994) l(2)34Da (Ashburner et al., 1999, The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Alexandrova et al., 1996, Roote et al., 1996, ) l(2)03782   l(2)br38 (The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Gubb et al., 1986, Gubb et al., 1984, ) l(2)c00136   l(2)k01403 (Chen et al., 1998) unnamed (Thibault et al., 2004)
Name Synonym	Kuzbanian (Loewer et al., 2004, Prasad and Montell, 2007, Talora et al., 2008) kuzbanian (Nicholson et al., 2008, Albrecht et al., 2006, Yepiskoposyan et al., 2006, Langdon et al., 2006, Zeitouni et al., 2007, Wang et al., 2007, Kankel et al., 2007, Wang et al., 2006, Shalaby et al., 2009, Udolph et al., 2009, Lake et al., 2009, Terriente-Félix et al., 2010, Coleman et al., 2010) kuzbaninan (Carmine-Simmen et al., 2009) lethal (2) c00136
Secondary FlyBase IDs
	FBgn0001958 FBgn0010555 FBgn0015954 FBgn0069197 FBgn0086292
References ( 171 )
Generate a list of	All references relating to this gene ( 171 )
List References by type	Research paper  ( 74 ) Supplementary material  ( 11 ) Review  ( 35 ) Personal communication to FlyBase  ( 22 ) Abstract  ( 14 ) FlyBase analysis  ( 3 ) Stock list  ( 1 ) Computer file  ( 4 ) Curated genome annotation  ( 2 ) Automatic genome annotation  ( 1 ) Book  ( 1 ) Conference report  ( 3 )
Recent research papers ( 4 )
	Coleman et al., 2010, Development 137(14): 2417--2426 The Adam family metalloprotease Kuzbanian regulates the cleavage of the roundabout receptor to control axon repulsion at the midline. [FBrf0211121] Egger et al., 2010, Development 137(18): 2981--2987 Notch regulates the switch from symmetric to asymmetric neural stem cell division in the Drosophila optic lobe. [FBrf0211572] Saj et al., 2010, Dev. Cell 18(5): 862--876 A combined ex vivo and in vivo RNAi screen for notch regulators in Drosophila reveals an extensive notch interaction network. [FBrf0210834] Terriente-Félix et al., 2010, Genetics 185(2): 671--684 Identification of genes affecting wing patterning through a loss-of-function mutagenesis screen and characterization of med15 function during wing development. [FBrf0211230] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...