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Gene Dmel\Mppe

General Information
Symbol	Dmel\Mppe	Species	D. melanogaster
Name	Metallophosphoesterase	Annotation symbol	CG8889
Feature type	protein_coding_gene	FlyBase ID	FBgn0259985
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	48D7-48D7	Sequence location	2R:7,913,004..7,915,212 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Metallophosphoesterase is referred to in FlyBase by the symbol Dmel\Mppe (CG8889, FBgn0259985). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: phosphatase activity. There is experimental evidence that it is involved in the biological process: protein dephosphorylation. 10 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Metallophosphoesterase domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye. Expression at moderate levels in the following post-embryonic organs or tissues: adult brain, adult crop, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1638001_a_at completely aligns to an exonic region of only a subset of 2 of the 3 FlyBase-annotated transcript isoforms of CG8889. Gene sequence location is 2R:7913004..7915212.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Transgenic Constructs P{hs-Mppe.C} P{UAS-Mppe.Delta} P{trp-Mppe.C} Controlled Vocabulary Terms Golgi apparatus protein dephosphorylation phosphatase activity Alleles Mppe[trp.PC] Mppe[hs.PC] Mppe[Delta.Scer\UAS] References Cao et al., 2011, EMBO J. 30(18): 3701--3713 Sequence features HFA07296 BKN24405
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 48D7-48D7   Limits computationally determined from genome sequence between P{lacW}l(2)k06612k06612 and P{lacW}jebk05644
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Mppe for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Mppe-RA FBtr0088024  NM_138562   1757   355 Mppe-RB FBtr0088025  NM_165861   1763   357 Mppe-RC FBtr0088026  NM_206098   1820   79
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Mppe-PA   FBpp0087131   41.6   355   9.15     NP_612572   AAF58594 Mppe-PB   FBpp0087132   41.9   357   9.28     NP_725099   AAM71025 Mppe-PC   FBpp0087133   9.0   79   8.49     NP_995820   AAS64863
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Metallophosphoesterase domain (IPR004843)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA698022   AA698032   AA816930   AE013599 AAF58594   AE013599 AAM71025   AE013599 AAS64863   AI109281   AI455209   AY069486 AAL39631   BH759588   BI361756   BI366950   BI368678   BI369169   BI372683   BI485113   BI563513   BI570607   BI571780   BI588093   BI588144   BI590993   BI591569   BI591728   BI591757   BI591792   BI620211   BI621288   BT120321   CO176913   CO179496   CO190939   CO263776   CO266910   CO267373   CO269549   CO273069   CO281042   CO286230   CO303794   CO322717   CZ480674   EC071902   EC073115   EC079085   EC197404   EC198333   EC199110   EC206396   EC218818   EC222013   EC225282   EC230448   EC244167   EC246519   ES690333   ES690350   ES690393   ES693332   ES693388   ES693463   ES693507   ES693510   ES693511   ES693678   ES693727   ES693787   ES693843   ES693858   ES693880   ES693912   ES693963   ES694048   ES694107   GH941473   GH942004   GH944081   GH944117   GH944258   GH946414   GH947601   GH951784   GH952483   GH953840   GH955338   GH957271   GH957831   GH958568   GH959073   GH960183   GH960411   GH960694   GH961616   GH962880   GH963255   GH966534   GH966888   GH968449   GH970170   GH972706   GH974661   GH975982   GH976227   GH981049   GH982097   GH982933   GH983363   GH983897
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8T085 A1Z8S4 A1Z8S5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
expression microarray Stage Tissue/Position (including subcellular localization) Reference adult stage   eye   (Xu et al., 2004)
Additional Descriptive Data
	Eye-enriched transcripts determined by ratio of expression level in wild-type heads. versus expression level in so heads. (Xu et al., 2004)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0259985    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0259985 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0259985 expression level Developmental Stage   Expression Level embryo 00-02hr    1812 embryo 02-04hr    1935 embryo 04-06hr    1463 embryo 06-08hr    964 embryo 08-10hr    1048 embryo 10-12hr    743 embryo 12-14hr    702 embryo 14-16hr    479 embryo 16-18hr    462 embryo 18-20hr    222 embryo 20-22hr    758 embryo 22-24hr    759 larva L1    205 larva L2    304 larva L3 12hr old    215 larva L3 puffstage 1-2    318 larva L3 puffstage 3-6    378 larva L3 puffstage 7-9    535 white prepupae new    498 white prepupae 12hr    584 white prepupae 24hr    768 pupae 2d postWPP    966 pupae 3d postWPP    1521 pupae 4d postWPP    329 adult male 01day    955 adult male 05day    1296 adult male 30day    1224 adult female 01day    626 adult female 05day    1249 adult female 30day    1255 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1812) embryo 02-04hr  (1935) embryo 04-06hr  (1463) embryo 06-08hr  (964) embryo 08-10hr  (1048) embryo 10-12hr  (743) embryo 12-14hr  (702) embryo 14-16hr  (479) embryo 16-18hr  (462) embryo 18-20hr  (222) embryo 20-22hr  (758) embryo 22-24hr  (759) larva L1  (205) larva L2  (304) larva L3 12hr old  (215) larva L3 puffstage 1-2  (318) larva L3 puffstage 3-6  (378) larva L3 puffstage 7-9  (535) white prepupae new  (498) white prepupae 12hr  (584) white prepupae 24hr  (768) pupae 2d postWPP  (966) pupae 3d postWPP  (1521) pupae 4d postWPP  (329) adult male 01day  (955) adult male 05day  (1296) adult male 30day  (1224) adult female 01day  (626) adult female 05day  (1249) adult female 30day  (1255) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1812) embryo 02-04hr  (1935) embryo 04-06hr  1463 embryo 06-08hr    964 embryo 08-10hr    1048 embryo 10-12hr    743 embryo 12-14hr    702 embryo 14-16hr    479 embryo 16-18hr    462 embryo 18-20hr    222 embryo 20-22hr    758 embryo 22-24hr    759 larva L1    205 larva L2    304 larva L3 12hr old    215 larva L3 puffstage 1-2    318 larva L3 puffstage 3-6    378 larva L3 puffstage 7-9    535 white prepupae new    498 white prepupae 12hr    584 white prepupae 24hr    768 pupae 2d postWPP    966 pupae 3d postWPP  (1521) pupae 4d postWPP    329 adult male 01day    955 adult male 05day    1296 adult male 30day    1224 adult female 01day    626 adult female 05day    1249 adult female 30day    1255 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1812 embryo 02-04hr    1935 embryo 04-06hr    1463 embryo 06-08hr    964 embryo 08-10hr    1048 embryo 10-12hr    743 embryo 12-14hr    702 embryo 14-16hr    479 embryo 16-18hr    462 embryo 18-20hr    222 embryo 20-22hr    758 embryo 22-24hr    759 larva L1    205 larva L2    304 larva L3 12hr old    215 larva L3 puffstage 1-2    318 larva L3 puffstage 3-6    378 larva L3 puffstage 7-9    535 white prepupae new    498 white prepupae 12hr    584 white prepupae 24hr    768 pupae 2d postWPP    966 pupae 3d postWPP    1521 pupae 4d postWPP    329 adult male 01day    955 adult male 05day    1296 adult male 30day    1224 adult female 01day    626 adult female 05day    1249 adult female 30day    1255 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1812 embryo 02-04hr    1935 embryo 04-06hr    1463 embryo 06-08hr    964 embryo 08-10hr    1048 embryo 10-12hr    743 embryo 12-14hr    702 embryo 14-16hr    479 embryo 16-18hr    462 embryo 18-20hr    222 embryo 20-22hr    758 embryo 22-24hr    759 larva L1    205 larva L2    304 larva L3 12hr old    215 larva L3 puffstage 1-2    318 larva L3 puffstage 3-6    378 larva L3 puffstage 7-9    535 white prepupae new    498 white prepupae 12hr    584 white prepupae 24hr    768 pupae 2d postWPP    966 pupae 3d postWPP    1521 pupae 4d postWPP    329 adult male 01day    955 adult male 05day    1296 adult male 30day    1224 adult female 01day    626 adult female 05day    1249 adult female 30day    1255 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0259985 expression level Developmental Stage   Expression Level embryo 00-02hr    1812 embryo 02-04hr    1935 embryo 04-06hr    1463 embryo 06-08hr    964 embryo 08-10hr    1048 embryo 10-12hr    743 embryo 12-14hr    702 embryo 14-16hr    479 embryo 16-18hr    462 embryo 18-20hr    222 embryo 20-22hr    758 embryo 22-24hr    759 larva L1    205 larva L2    304 larva L3 12hr old    215 larva L3 puffstage 1-2    318 larva L3 puffstage 3-6    378 larva L3 puffstage 7-9    535 white prepupae new    498 white prepupae 12hr    584 white prepupae 24hr    768 pupae 2d postWPP    966 pupae 3d postWPP    1521 pupae 4d postWPP    329 adult male 01day    955 adult male 05day    1296 adult male 30day    1224 adult female 01day    626 adult female 05day    1249 adult female 30day    1255 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1812) embryo 02-04hr  (1935) embryo 04-06hr  (1463) embryo 06-08hr  (964) embryo 08-10hr  (1048) embryo 10-12hr  (743) embryo 12-14hr  (702) embryo 14-16hr  (479) embryo 16-18hr  (462) embryo 18-20hr  (222) embryo 20-22hr  (758) embryo 22-24hr  (759) larva L1  (205) larva L2  (304) larva L3 12hr old  (215) larva L3 puffstage 1-2  (318) larva L3 puffstage 3-6  (378) larva L3 puffstage 7-9  (535) white prepupae new  (498) white prepupae 12hr  (584) white prepupae 24hr  (768) pupae 2d postWPP  (966) pupae 3d postWPP  (1521) pupae 4d postWPP  (329) adult male 01day  (955) adult male 05day  (1296) adult male 30day  (1224) adult female 01day  (626) adult female 05day  (1249) adult female 30day  (1255) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1812 embryo 02-04hr  1935 embryo 04-06hr  1463 embryo 06-08hr    964 embryo 08-10hr    1048 embryo 10-12hr    743 embryo 12-14hr    702 embryo 14-16hr    479 embryo 16-18hr    462 embryo 18-20hr    222 embryo 20-22hr    758 embryo 22-24hr    759 larva L1    205 larva L2    304 larva L3 12hr old    215 larva L3 puffstage 1-2    318 larva L3 puffstage 3-6    378 larva L3 puffstage 7-9    535 white prepupae new    498 white prepupae 12hr    584 white prepupae 24hr    768 pupae 2d postWPP    966 pupae 3d postWPP  1521 pupae 4d postWPP    329 adult male 01day    955 adult male 05day    1296 adult male 30day    1224 adult female 01day    626 adult female 05day    1249 adult female 30day    1255 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1812 embryo 02-04hr    1935 embryo 04-06hr    1463 embryo 06-08hr    964 embryo 08-10hr    1048 embryo 10-12hr    743 embryo 12-14hr    702 embryo 14-16hr    479 embryo 16-18hr    462 embryo 18-20hr    222 embryo 20-22hr    758 embryo 22-24hr    759 larva L1    205 larva L2    304 larva L3 12hr old    215 larva L3 puffstage 1-2    318 larva L3 puffstage 3-6    378 larva L3 puffstage 7-9    535 white prepupae new    498 white prepupae 12hr    584 white prepupae 24hr    768 pupae 2d postWPP    966 pupae 3d postWPP    1521 pupae 4d postWPP    329 adult male 01day    955 adult male 05day    1296 adult male 30day    1224 adult female 01day    626 adult female 05day    1249 adult female 30day    1255 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1812 embryo 02-04hr    1935 embryo 04-06hr    1463 embryo 06-08hr    964 embryo 08-10hr    1048 embryo 10-12hr    743 embryo 12-14hr    702 embryo 14-16hr    479 embryo 16-18hr    462 embryo 18-20hr    222 embryo 20-22hr    758 embryo 22-24hr    759 larva L1    205 larva L2    304 larva L3 12hr old    215 larva L3 puffstage 1-2    318 larva L3 puffstage 3-6    378 larva L3 puffstage 7-9    535 white prepupae new    498 white prepupae 12hr    584 white prepupae 24hr    768 pupae 2d postWPP    966 pupae 3d postWPP    1521 pupae 4d postWPP    329 adult male 01day    955 adult male 05day    1296 adult male 30day    1224 adult female 01day    626 adult female 05day    1249 adult female 30day    1255 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0259985    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0259985 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye. Expression at moderate levels in the following post-embryonic organs or tissues: adult brain, adult crop, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0259985 expression level Tissue   Expression Level Larval Central Nervous System    90.775 Larval Midgut no informative data Larval Hindgut    47.3 Larval Malpighian Tubules no informative data Larval Fat Body    44.1 Larval Salivary Gland    148.7 Larval Trachea    135.025 Larval Carcass    47.5 Adult Head    1090.2 Adult Eye    3976.6 Adult Brain    130.8 Adult Thoracic-Abdominal Ganglion    80.1 Adult Crop    109.3 Adult Midgut no informative data Adult Hindgut    58.4 Adult Malpighian Tubules    27.8 Adult Fat Body    39.7 Adult Salivary Gland    152.1 Adult Heart    62.125 Adult VirginFemale Spermatheca    40.1 Adult InseminatedFemale Spermatheca    50.5 Adult Ovary    178.1 Adult Testis    91.8 Adult Male Accessory Gland    108.9 Adult Carcass    49.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    90.775 Larval Midgut no informative data Larval Hindgut    47.3 Larval Malpighian Tubules no informative data Larval Fat Body    44.1 Larval Salivary Gland    148.7 Larval Trachea    135.025 Larval Carcass    47.5 Adult Head  (1090.2) Adult Eye  (3976.6) Adult Brain    130.8 Adult Thoracic-Abdominal Ganglion    80.1 Adult Crop    109.3 Adult Midgut no informative data Adult Hindgut    58.4 Adult Malpighian Tubules    27.8 Adult Fat Body    39.7 Adult Salivary Gland    152.1 Adult Heart    62.125 Adult VirginFemale Spermatheca    40.1 Adult InseminatedFemale Spermatheca    50.5 Adult Ovary    178.1 Adult Testis    91.8 Adult Male Accessory Gland    108.9 Adult Carcass    49.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    90.775 Larval Midgut no informative data Larval Hindgut    47.3 Larval Malpighian Tubules no informative data Larval Fat Body    44.1 Larval Salivary Gland    148.7 Larval Trachea    135.025 Larval Carcass    47.5 Adult Head  (1090.2) Adult Eye  (3976.6) Adult Brain    130.8 Adult Thoracic-Abdominal Ganglion    80.1 Adult Crop    109.3 Adult Midgut no informative data Adult Hindgut    58.4 Adult Malpighian Tubules    27.8 Adult Fat Body    39.7 Adult Salivary Gland    152.1 Adult Heart    62.125 Adult VirginFemale Spermatheca    40.1 Adult InseminatedFemale Spermatheca    50.5 Adult Ovary    178.1 Adult Testis    91.8 Adult Male Accessory Gland    108.9 Adult Carcass    49.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    90.775 Larval Midgut no informative data Larval Hindgut    47.3 Larval Malpighian Tubules no informative data Larval Fat Body    44.1 Larval Salivary Gland    148.7 Larval Trachea    135.025 Larval Carcass    47.5 Adult Head    1090.2 Adult Eye    3976.6 Adult Brain    130.8 Adult Thoracic-Abdominal Ganglion    80.1 Adult Crop    109.3 Adult Midgut no informative data Adult Hindgut    58.4 Adult Malpighian Tubules    27.8 Adult Fat Body    39.7 Adult Salivary Gland    152.1 Adult Heart    62.125 Adult VirginFemale Spermatheca    40.1 Adult InseminatedFemale Spermatheca    50.5 Adult Ovary    178.1 Adult Testis    91.8 Adult Male Accessory Gland    108.9 Adult Carcass    49.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0259985 expression level Tissue   Expression Level Larval Central Nervous System    90.775 Larval Midgut no informative data Larval Hindgut    47.3 Larval Malpighian Tubules no informative data Larval Fat Body    44.1 Larval Salivary Gland    148.7 Larval Trachea    135.025 Larval Carcass    47.5 Adult Head    1090.2 Adult Eye    3976.6 Adult Brain    130.8 Adult Thoracic-Abdominal Ganglion    80.1 Adult Crop    109.3 Adult Midgut no informative data Adult Hindgut    58.4 Adult Malpighian Tubules    27.8 Adult Fat Body    39.7 Adult Salivary Gland    152.1 Adult Heart    62.125 Adult VirginFemale Spermatheca    40.1 Adult InseminatedFemale Spermatheca    50.5 Adult Ovary    178.1 Adult Testis    91.8 Adult Male Accessory Gland    108.9 Adult Carcass    49.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    90.775 Larval Midgut no informative data Larval Hindgut    47.3 Larval Malpighian Tubules no informative data Larval Fat Body    44.1 Larval Salivary Gland    148.7 Larval Trachea    135.025 Larval Carcass    47.5 Adult Head  (1090.2) Adult Eye  (3976.6) Adult Brain    130.8 Adult Thoracic-Abdominal Ganglion    80.1 Adult Crop    109.3 Adult Midgut no informative data Adult Hindgut    58.4 Adult Malpighian Tubules    27.8 Adult Fat Body    39.7 Adult Salivary Gland    152.1 Adult Heart    62.125 Adult VirginFemale Spermatheca    40.1 Adult InseminatedFemale Spermatheca    50.5 Adult Ovary    178.1 Adult Testis    91.8 Adult Male Accessory Gland    108.9 Adult Carcass    49.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    90.775 Larval Midgut no informative data Larval Hindgut    47.3 Larval Malpighian Tubules no informative data Larval Fat Body    44.1 Larval Salivary Gland    148.7 Larval Trachea    135.025 Larval Carcass    47.5 Adult Head  1090.2 Adult Eye  (3976.6) Adult Brain    130.8 Adult Thoracic-Abdominal Ganglion    80.1 Adult Crop    109.3 Adult Midgut no informative data Adult Hindgut    58.4 Adult Malpighian Tubules    27.8 Adult Fat Body    39.7 Adult Salivary Gland    152.1 Adult Heart    62.125 Adult VirginFemale Spermatheca    40.1 Adult InseminatedFemale Spermatheca    50.5 Adult Ovary    178.1 Adult Testis    91.8 Adult Male Accessory Gland    108.9 Adult Carcass    49.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    90.775 Larval Midgut no informative data Larval Hindgut    47.3 Larval Malpighian Tubules no informative data Larval Fat Body    44.1 Larval Salivary Gland    148.7 Larval Trachea    135.025 Larval Carcass    47.5 Adult Head    1090.2 Adult Eye    3976.6 Adult Brain    130.8 Adult Thoracic-Abdominal Ganglion    80.1 Adult Crop    109.3 Adult Midgut no informative data Adult Hindgut    58.4 Adult Malpighian Tubules    27.8 Adult Fat Body    39.7 Adult Salivary Gland    152.1 Adult Heart    62.125 Adult VirginFemale Spermatheca    40.1 Adult InseminatedFemale Spermatheca    50.5 Adult Ovary    178.1 Adult Testis    91.8 Adult Male Accessory Gland    108.9 Adult Carcass    49.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules no informative data Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1090.2   NA  Eye    3976.6   NA  Brain    130.8   90.775  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    80.1   NA  Crop    109.3   no informative data  Midgut    no informative data   47.3  Hindgut    58.4   no informative data  Malpighian Tubules    27.8   44.1  Fat Body    39.7   148.7  Salivary Gland    152.1   NA  Heart    62.125   135.025  Trachea    NA   NA  VirginFemale Spermatheca    40.1   NA  InseminatedFemale Spermatheca    50.5   NA  Ovary    178.1   NA  Testis    91.8   NA  Male Accessory Gland    108.9   47.5  Carcass    49.6 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_01
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259985
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Mppee02905 viable, with Scer\GAL4pnr-MD237 MppeGD3523 Other Phenotypes Allele neurophysiology defective | adult stage Mppee02905 Phenotype manifest in Allele rhabdomere | conditional Mppee02905
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of Mppe Class Mutagen Stocks Known lesion Mppec01790 1 -- Mppee02905 piggyBac transposase 1 -- Mppef03583 1 -- MppeGS11471 1 -- MppeKG05213 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Mppe Class Mutagen Stocks Known lesion MppeKK105269 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes MppeGD3523 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Mppehs.PC in vitro construct - regulatory fusion 0 Yes Mppetrp.PC in vitro construct - regulatory fusion 0 Yes MppeΔ.Scer\UAS in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data heat-shock construct P{hs-Mppe.C} NA UAS construct P{UAS-Mppe.Δ} NA characterization construct P{trp-Mppe.C} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}MppeKG05213 NA PBac{PB}Mppec01790 NA PBac{RB}Mppee02905 NA PBac{WH}Mppef03583 NA insertion of mobile activating element P{GSV6}MppeGS11471 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function
CV term Evidence References
phosphatase activity inferred from direct assay (Cao et al., 2011)
Biological Process
CV term Evidence References
protein dephosphorylation inferred from direct assay (Cao et al., 2011) inferred from mutant phenotype (Cao et al., 2011)
Cellular Component
CV term Evidence References
Golgi apparatus inferred from direct assay (Cao et al., 2011)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	gene (Laviolette et al., 2005) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Mppe allele Gene References unspecified Nsf2 (Laviolette et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62069 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0259985 DroID - A comprehensive database of gene and protein interactions. • FBgn0259985 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36285
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12647 Dere\GG22612 Dgri\GH21045 Dmoj\GI18647 Dper\GL11542 Dpse\GA21393 Dsec\GM20391 Dsim\GD25866 Dvir\GJ21663 Dwil\GK21981 Dyak\GE13480
Curated drosophilid orthologs	Dpse\GA21393   Dsim\CG8889 (Swanson et al., 2001)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL001670-PA Aedes aegypti (mosquito) AGAP007828-PA Anopheles gambiae (mosquito) XP_001119988.1 Apis mellifera (honey bee) XP_001950146.1 Acyrthosiphon pisum (pea aphid) 107963 Branchiostoma floridae (lancelet) 126917 Branchiostoma floridae (lancelet) BGIBMGA003778-PA Bombyx mori (silk worm) CAL0004680 Candida albicans (a form of yeast) CBP31307 Caenorhabditis briggsae (nematode) CE40542 Caenorhabditis elegans (worm) JA08186 Caenorhabditis japonica (nematode) CPIJ000947 Culex pipens (mosquito) RP31126 Caenorhabditis remanei (nematode) RP42964 Caenorhabditis remanei (nematode) 121495 Capitella spl (polychaete worm) DDB0205695 Dictyostelium discoideum (amoeba) DEHA2D13596g Debaryomyces Hansenii (yeast) 307927 Daphnia pulex (daphnia) 185536 Hypsipyla robusta (cedar shoot borer) ISCW008365-PA Ixodes scapularis (deer tick) 237661 Lottia gigantea (owl limpet) PHUM005307-PA Pediculus humanus (human body louse) Smp_017860 Schistosoma mansoni (trematode parasite) XP_001183693.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001199678.1 Strongylocentrotus purpuratus (purple sea urchin) XP_974434.1 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14944 NV19225 LH11045 ISCW008365 FBgn0231149 FBgn0223966 FBgn0208782 FBgn0197146 FBgn0175274 JGI_V11_307927 FBgn0081381 FBgn0149151 FBgn0141386 FBgn0128507 FBgn0114783 FBgn0089683 BGIBMGA014314 BGIBMGA003778 ACYPI004540 GB11531 PHUM221340 GLEAN_03487
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	13884 y1 w67c23; P{SUPor-P}MppeKG05213
Harvard	- PBac{PB}Mppec01790 - PBac{RB}Mppee02905 - PBac{WH}Mppef03583
Kyoto	205305 y1 w67c23; P{GSV6}MppeGS11471/SM1
VDRC	v108190 P{KK105269}VIE-260B
Genomic Clones ( 2 )
	BACR04E21 BACR14L19 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 82 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD21768 RE57611
Other clones	DPiM_LD21768
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH08423 HL03643 HL03656 RE46105 RE52604 RE54686 RE55274 RE59720 RE68392 RH04688 RH05366 RH06309 RH06702 RH06735 RH06771 RH07069 RH29117 RH29231 RH34158 RH51292 RH52607
Other clones	9861 21248 28487 36878 37315 63152 102247 194845 CK01.27C.E12 CK01.76B.A12 CK01.80A.E12 CK01.132A.F7 EK050206 EK051606 EK059536 EK062150 EK094924 EK109416 EK136424 EK147914 EK149823 EK155823 EK188726 EK242752 RP004014054 RP004030170 RP004049670 RP004062173 RP004099561 RP004124146 RP004143712 RP004153641 RP004203735 RP004207930 RP004210589 RP004216128 RP004220600 RP004224656 RP004235319 RP004243111 RP004243727 RP004246852 RP004260366 RP004267711 RP004324299 RP004330531 RP004359342 RP004393311 RP004431236 RP004454657 RP004474827 RP004479486 RP004516181 RP004520296 RP004534379 RP004544054 RP004545397 RP004548000
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0259985 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36285
Antibody Information
	polyclonal (Cao et al., 2011)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Mppe CG8889 (Cao et al., 2011)
Source for database merge of	Source for merge of: CG8889 GS11471 (FlyBase, 1996-)
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_138562 NM_165861 NM_206098 RefSeq (Proteins) • NP_612572 NP_725099 NP_995820 DDBJ / EMBL / GenBank • AA816930 AAF58594 AAL39631 AAM71025 AAS64863 AI455209 AY069486 BH759588 CZ480674 Entrez Gene - A searchable database of RefSeq genes. • 36285 UniProtKB/TrEMBL • A1Z8S4 A1Z8S5 Q8T085
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Metallophosphoesterase domain (IPR004843)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62069 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0259985 DroID - A comprehensive database of gene and protein interactions. • FBgn0259985 DRSC - Results from RNAi screens. • FBgn0259985 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259985 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0259985 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36285 InParanoid A subset of ortholog calls from InParanoid. • AAEL001670-PA Aedes aegypti (mosquito) AGAP007828-PA Anopheles gambiae (mosquito) XP_001119988.1 Apis mellifera (honey bee) XP_001950146.1 Acyrthosiphon pisum (pea aphid) 107963 Branchiostoma floridae (lancelet) 126917 Branchiostoma floridae (lancelet) BGIBMGA003778-PA Bombyx mori (silk worm) CAL0004680 Candida albicans (a form of yeast) CBP31307 Caenorhabditis briggsae (nematode) CE40542 Caenorhabditis elegans (worm) JA08186 Caenorhabditis japonica (nematode) CPIJ000947 Culex pipens (mosquito) RP31126 Caenorhabditis remanei (nematode) RP42964 Caenorhabditis remanei (nematode) 121495 Capitella spl (polychaete worm) DDB0205695 Dictyostelium discoideum (amoeba) DEHA2D13596g Debaryomyces Hansenii (yeast) 307927 Daphnia pulex (daphnia) 185536 Hypsipyla robusta (cedar shoot borer) ISCW008365-PA Ixodes scapularis (deer tick) 237661 Lottia gigantea (owl limpet) PHUM005307-PA Pediculus humanus (human body louse) Smp_017860 Schistosoma mansoni (trematode parasite) XP_001183693.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001199678.1 Strongylocentrotus purpuratus (purple sea urchin) XP_974434.1 Tribolium castaneum (red flour beetle) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36285 modMine - Data generated by the modENCODE project. • FBgn0259985 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14944 NV19225 LH11045 ISCW008365 FBgn0231149 FBgn0223966 FBgn0208782 FBgn0197146 FBgn0175274 JGI_V11_307927 FBgn0081381 FBgn0149151 FBgn0141386 FBgn0128507 FBgn0114783 FBgn0089683 BGIBMGA014314 BGIBMGA003778 ACYPI004540 GB11531 PHUM221340 GLEAN_03487
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	11471 (Laviolette et al., 2005) CG8889 (Ranade et al., 2008, Cao et al., 2011, Kim et al., 2010, Keleman et al., 2009.8.5, Scherzer et al., 2003) dmppe (Cao et al., 2011) GS11471   Mppe
Name Synonym	metallophosphoesterase (Cao et al., 2011) Metallophosphoesterase
Secondary FlyBase IDs
	FBgn0033675 FBgn0086293
References ( 20 )
Research paper	Cao et al., 2011, EMBO J. 30(18): 3701--3713 A Drosophila metallophosphoesterase mediates deglycosylation of rhodopsin. [FBrf0215269] Kim et al., 2010, Mol. Cells 29(1): 93--98 Blood-brain barrier defects associated with Rbp9 mutation. [FBrf0210543] Ranade et al., 2008, Dev. Biol. 315(2): 521--534 Analysis of the Otd-dependent transcriptome supports the evolutionary conservation of CRX/OTX/OTD functions in flies and vertebrates. [FBrf0204284] Laviolette et al., 2005, Genetics 170(2): 779--792 A genetic screen for suppressors of Drosophila NSF2 neuromuscular junction overgrowth. [FBrf0187645] Xu et al., 2004, EMBO J. 23(4): 811--822 A lysosomal tetraspanin associated with retinal degeneration identified via a genome-wide screen. [FBrf0174603] Scherzer et al., 2003, Hum. Molec. Genet. 12(19): 2457--2466 Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease. [FBrf0162171]
Supplementary material	Khanna et al., 2010, BMC Genomics 11(1): Towards a membrane proteome in Drosophila: a method for the isolation of plasma membrane. [FBrf0210978] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Dietzl et al., 2007, Nature 448(7150): Supplementary Table 1. [FBrf0202579] Swanson et al., 2001, Proc. Natl. Acad. Sci. USA 98: Gene characteristics and dN/dS ratios of Drosophila simulans. [FBrf0137427]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. Genomic mapping of Exelixis insertion collection. [FBrf0184340] Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Curated genome annotation	Yao, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126699]