Gene model reviewed during 5.45
Alternative translation stop created by use of multiphasic reading frames within coding region.
None of the polypeptides share 100% sequence identity.
Interacts with sqz and rn. Able to bind mammalian EGR1 but not Drosophila EGR-like protein klu.
The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\nab using the Feature Mapper tool.
nab expression in wing discs is first seen in late second instar/early third instar as a small group of cells in the center of the rn domain. The dve domain is broader than the nab domain in the presumptive wing. The dve and nab domains are nearly complementary to the zfh2 domain.
nab is expressed just before the thoracic neuroblast 3-3 produces its last GMC that gives rise to the sixth-born EL neuron.
A low level of nab expression is seen in all imaginal discs. In late third instar wing discs, nab was strongly expressed in a circular domain that delimits the expression of wg in the IR. A low level of expression is seen in the rest of the wing disc, except in the hinge region. nab expression is detected in a stripe corresponding to the morphogenetic furrow in the eye disc.
GBrowse - Visual display of RNA-Seq signalsView Dmel\nab in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Annotations CG15000 and CG15001 merged as CG33545 (which corresponds to nab) in release 4.1 of the genome annotation.