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Gene Dmel\nab

General Information
Symbol	Dmel\nab	Species	D. melanogaster
Name	nab	Annotation symbol	CG33545
Feature type	protein_coding_gene	FlyBase ID	FBgn0259986
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	CG15000, CG15001, dnab
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	64A8-64A8	Sequence location	3L:4,153,618..4,160,932 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene nab is referred to in FlyBase by the symbol Dmel\nab (CG33545, FBgn0259986). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: transcription cofactor activity. There is experimental evidence that it is involved in the biological process: locomotory behavior; cell proliferation; neuron development; wing disc pattern formation; neuroblast development. 19 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; adult segment; organ system; thoracic segment; embryonic/larval neuron; external compound sense organ; appendage segment; adult; eo support cell; pigment cell; sense organ; imaginal precursor. It has 2 annotated transcripts and 2 annotated polypeptides. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of no expression detected. Peak expression observed within 06-18 hour embryonic stages, during late larval stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system. Gene sequence location is 3L:4153618..4160932.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features HFA08456 HFA08455 BKN30447
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 64A8-64A8   Limits computationally determined from genome sequence between P{PZ}l(3)rG166rG166 and P{PZ}sinu06524
Experimentally Determined Cytological Location
Cytogenetic map Notes References 64A8-64A8     (Oh et al., 2003)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\nab for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) nab-RB FBtr0302032  NM_001169873   2470   564 nab-RC FBtr0302033  NM_001014557   2385   625
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein nab-PB   FBpp0291242   60.7   564   7.76     NP_001163344   ACZ94616 nab-PC   FBpp0291243   66.5   625   6.71     NP_001014557   AAX52730
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAX52730   AB082911   AE014296 ACZ94616   BT046160   CO295288   CO341005   EC236147   EC253432   EW712738
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 14 -- 16   neuroblast NB3-3 of thorax   (Tsuji et al., 2008) neuroblast NB3-3 of embryonic abdomen   (Tsuji et al., 2008) larval stage   ganglion mother cell | subset   (Tsuji et al., 2008) EL neuron | subset   (Tsuji et al., 2008) second instar larval stage -- third instar larval stage   neuroblast NB3-3 of thorax   (Tsuji et al., 2008)
Additional Descriptive Data
	nab is expressed just before the thoracic neuroblast 3-3 produces its last GMC that gives rise to the sixth-born EL neuron. (Tsuji et al., 2008)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0259986    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0259986 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of no expression detected. Peak expression observed within 06-18 hour embryonic stages, during late larval stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0259986 expression level Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    54 embryo 04-06hr    30 embryo 06-08hr    155 embryo 08-10hr    420 embryo 10-12hr    691 embryo 12-14hr    404 embryo 14-16hr    254 embryo 16-18hr    138 embryo 18-20hr    106 embryo 20-22hr    58 embryo 22-24hr    67 larva L1    89 larva L2    117 larva L3 12hr old    150 larva L3 puffstage 1-2    249 larva L3 puffstage 3-6    406 larva L3 puffstage 7-9    459 white prepupae new    388 white prepupae 12hr    367 white prepupae 24hr    460 pupae 2d postWPP    37 pupae 3d postWPP    16 pupae 4d postWPP    43 adult male 01day    22 adult male 05day    28 adult male 30day    36 adult female 01day    2 adult female 05day    0 adult female 30day    1 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    54 embryo 04-06hr    30 embryo 06-08hr  (155) embryo 08-10hr  (420) embryo 10-12hr  (691) embryo 12-14hr  (404) embryo 14-16hr  (254) embryo 16-18hr  (138) embryo 18-20hr  106 embryo 20-22hr    58 embryo 22-24hr    67 larva L1    89 larva L2  (117) larva L3 12hr old  (150) larva L3 puffstage 1-2  (249) larva L3 puffstage 3-6  (406) larva L3 puffstage 7-9  (459) white prepupae new  (388) white prepupae 12hr  (367) white prepupae 24hr  (460) pupae 2d postWPP    37 pupae 3d postWPP    16 pupae 4d postWPP    43 adult male 01day    22 adult male 05day    28 adult male 30day    36 adult female 01day    2 adult female 05day    0 adult female 30day    1 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    54 embryo 04-06hr    30 embryo 06-08hr    155 embryo 08-10hr    420 embryo 10-12hr    691 embryo 12-14hr    404 embryo 14-16hr    254 embryo 16-18hr    138 embryo 18-20hr    106 embryo 20-22hr    58 embryo 22-24hr    67 larva L1    89 larva L2    117 larva L3 12hr old    150 larva L3 puffstage 1-2    249 larva L3 puffstage 3-6    406 larva L3 puffstage 7-9    459 white prepupae new    388 white prepupae 12hr    367 white prepupae 24hr    460 pupae 2d postWPP    37 pupae 3d postWPP    16 pupae 4d postWPP    43 adult male 01day    22 adult male 05day    28 adult male 30day    36 adult female 01day    2 adult female 05day    0 adult female 30day    1 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    54 embryo 04-06hr    30 embryo 06-08hr    155 embryo 08-10hr    420 embryo 10-12hr    691 embryo 12-14hr    404 embryo 14-16hr    254 embryo 16-18hr    138 embryo 18-20hr    106 embryo 20-22hr    58 embryo 22-24hr    67 larva L1    89 larva L2    117 larva L3 12hr old    150 larva L3 puffstage 1-2    249 larva L3 puffstage 3-6    406 larva L3 puffstage 7-9    459 white prepupae new    388 white prepupae 12hr    367 white prepupae 24hr    460 pupae 2d postWPP    37 pupae 3d postWPP    16 pupae 4d postWPP    43 adult male 01day    22 adult male 05day    28 adult male 30day    36 adult female 01day    2 adult female 05day    0 adult female 30day    1 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    54 embryo 04-06hr    30 embryo 06-08hr    155 embryo 08-10hr    420 embryo 10-12hr    691 embryo 12-14hr    404 embryo 14-16hr    254 embryo 16-18hr    138 embryo 18-20hr    106 embryo 20-22hr    58 embryo 22-24hr    67 larva L1    89 larva L2    117 larva L3 12hr old    150 larva L3 puffstage 1-2    249 larva L3 puffstage 3-6    406 larva L3 puffstage 7-9    459 white prepupae new    388 white prepupae 12hr    367 white prepupae 24hr    460 pupae 2d postWPP    37 pupae 3d postWPP    16 pupae 4d postWPP    43 adult male 01day    22 adult male 05day    28 adult male 30day    36 adult female 01day    2 adult female 05day    0 adult female 30day    1 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0259986 expression level Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    54 embryo 04-06hr    30 embryo 06-08hr    155 embryo 08-10hr    420 embryo 10-12hr    691 embryo 12-14hr    404 embryo 14-16hr    254 embryo 16-18hr    138 embryo 18-20hr    106 embryo 20-22hr    58 embryo 22-24hr    67 larva L1    89 larva L2    117 larva L3 12hr old    150 larva L3 puffstage 1-2    249 larva L3 puffstage 3-6    406 larva L3 puffstage 7-9    459 white prepupae new    388 white prepupae 12hr    367 white prepupae 24hr    460 pupae 2d postWPP    37 pupae 3d postWPP    16 pupae 4d postWPP    43 adult male 01day    22 adult male 05day    28 adult male 30day    36 adult female 01day    2 adult female 05day    0 adult female 30day    1 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    54 embryo 04-06hr    30 embryo 06-08hr  (155) embryo 08-10hr  (420) embryo 10-12hr  (691) embryo 12-14hr  (404) embryo 14-16hr  (254) embryo 16-18hr  138 embryo 18-20hr  106 embryo 20-22hr    58 embryo 22-24hr    67 larva L1    89 larva L2  117 larva L3 12hr old  (150) larva L3 puffstage 1-2  (249) larva L3 puffstage 3-6  (406) larva L3 puffstage 7-9  (459) white prepupae new  (388) white prepupae 12hr  (367) white prepupae 24hr  (460) pupae 2d postWPP    37 pupae 3d postWPP    16 pupae 4d postWPP    43 adult male 01day    22 adult male 05day    28 adult male 30day    36 adult female 01day    2 adult female 05day    0 adult female 30day    1 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    54 embryo 04-06hr    30 embryo 06-08hr    155 embryo 08-10hr    420 embryo 10-12hr    691 embryo 12-14hr    404 embryo 14-16hr    254 embryo 16-18hr    138 embryo 18-20hr    106 embryo 20-22hr    58 embryo 22-24hr    67 larva L1    89 larva L2    117 larva L3 12hr old    150 larva L3 puffstage 1-2    249 larva L3 puffstage 3-6    406 larva L3 puffstage 7-9    459 white prepupae new    388 white prepupae 12hr    367 white prepupae 24hr    460 pupae 2d postWPP    37 pupae 3d postWPP    16 pupae 4d postWPP    43 adult male 01day    22 adult male 05day    28 adult male 30day    36 adult female 01day    2 adult female 05day    0 adult female 30day    1 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    54 embryo 04-06hr    30 embryo 06-08hr    155 embryo 08-10hr    420 embryo 10-12hr    691 embryo 12-14hr    404 embryo 14-16hr    254 embryo 16-18hr    138 embryo 18-20hr    106 embryo 20-22hr    58 embryo 22-24hr    67 larva L1    89 larva L2    117 larva L3 12hr old    150 larva L3 puffstage 1-2    249 larva L3 puffstage 3-6    406 larva L3 puffstage 7-9    459 white prepupae new    388 white prepupae 12hr    367 white prepupae 24hr    460 pupae 2d postWPP    37 pupae 3d postWPP    16 pupae 4d postWPP    43 adult male 01day    22 adult male 05day    28 adult male 30day    36 adult female 01day    2 adult female 05day    0 adult female 30day    1 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    54 embryo 04-06hr    30 embryo 06-08hr    155 embryo 08-10hr    420 embryo 10-12hr    691 embryo 12-14hr    404 embryo 14-16hr    254 embryo 16-18hr    138 embryo 18-20hr    106 embryo 20-22hr    58 embryo 22-24hr    67 larva L1    89 larva L2    117 larva L3 12hr old    150 larva L3 puffstage 1-2    249 larva L3 puffstage 3-6    406 larva L3 puffstage 7-9    459 white prepupae new    388 white prepupae 12hr    367 white prepupae 24hr    460 pupae 2d postWPP    37 pupae 3d postWPP    16 pupae 4d postWPP    43 adult male 01day    22 adult male 05day    28 adult male 30day    36 adult female 01day    2 adult female 05day    0 adult female 30day    1 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0259986    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0259986 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_25
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259986
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | adult stage (with nabA23) nabe310 nabG26 lethal | adult stage (with nabe310) nabA23 lethal | adult stage (with nabG26) nabA23 lethal | embryonic stage | recessive nabA23 lethal | larval stage (with Df(3L)GN19) nabA23 nabe310 nabG26 lethal | larval stage (with nabe310) nabG26 lethal | larval stage (with nabG26) nabe310 lethal | larval stage (with nabNP3537) nabSH143 lethal | larval stage (with nabSH143) nabNP3537 lethal | larval stage | recessive nabe310 nabG26 nabNP3537 nabSH143 lethal | pupal stage (with nabe310) nabG26 lethal | pupal stage (with nabG26) nabe310 lethal | recessive nabA23 nabG26 nabSH143 nabunspecified semi-lethal | first instar larval stage | recessive nabSH143 viable nabEP13 viable, with Scer\GAL4pnr-MD237 nabGD1607 nabGD8511 Other Phenotypes Allele eye color defective, with Scer\GAL4GMR.PF nabScer\UAS.cCa flightless (with nabA23) nabe310 nabG26 flightless (with nabe310) nabA23 flightless (with nabG26) nabA23 hypoactive | larval stage nabe310 nabG26 hypoactive | larval stage (with Df(3L)GN19) nabA23 nabe310 nabG26 increased cell death, with Scer\GAL4ap.nd432 nabEP642 increased cell death, with Scer\GAL4hh.nd271 nabEP642 increased cell growth | cell non-autonomous | somatic clone, with Scer\GAL4Scer\FRT.Rnor\CD2.Act5C nabEP642 jumping defective (with nabA23) nabe310 nabG26 jumping defective (with nabe310) nabA23 jumping defective (with nabG26) nabA23 neuroanatomy defective | embryonic stage nabG26 nabSH143 uncoordinated | adult stage (with nabA23) nabe310 nabG26 uncoordinated | adult stage (with nabe310) nabA23 uncoordinated | adult stage (with nabG26) nabA23 uncoordinated | larval stage nabe310 nabG26 visible, with Scer\GAL4ey.PH nabScer\UAS.cCa visible, with Scer\GAL4GMR.PF nabScer\UAS.cCa visible, with Scer\GAL4hs.2sev nabScer\UAS.cCa visible, with Scer\GAL4nub-AC-62 nabEP13 visible, with Scer\GAL4pnr-MD237 nabGD8511 visible, with Scer\GAL4rn-GAL4-13 nabEP13 Phenotype manifest in Allele EL neuron nabA23 nabG26 nabe310 EL neuron | embryonic stage | supernumerary nabSH143 nabG26 eye, with Scer\GAL4ey.PH nabScer\UAS.cCa eye, with Scer\GAL4GMR.PF nabScer\UAS.cCa eye, with Scer\GAL4hs.2sev nabScer\UAS.cCa neuroblast NB3-3 | embryonic stage nabSH143 nabG26 ommatidium, with Scer\GAL4GMR.PF nabScer\UAS.cCa ommatidium, with Scer\GAL4hs.2sev nabScer\UAS.cCa pigment cell, with Scer\GAL4GMR.PF nabScer\UAS.cCa subesophageal ganglion neuron nabSH143 tarsal segment 2, with Scer\GAL4Dll-md23 nabEP13 tarsal segment 2, with Scer\GAL4rn-GAL4-13 nabEP13 tarsal segment 3, with Scer\GAL4Dll-md23 nabEP13 tarsal segment 3, with Scer\GAL4rn-GAL4-13 nabEP13 tarsal segment 4, with Scer\GAL4Dll-md23 nabEP13 tarsal segment 4, with Scer\GAL4rn-GAL4-13 nabEP13 thoracic neuroblast | embryonic stage nabSH143 nabG26 trichogen cell, with Scer\GAL4pnr-MD237 nabGD8511 Tv neuron | first instar larval stage nabSH143 wing disc, with Scer\GAL4ap.nd432 nabEP642 wing disc, with Scer\GAL4hh.nd271 nabEP642 wing hinge, with Scer\GAL4Dll-md23 nabEP13 wing hinge, with Scer\GAL4nub-AC-62 nabEP13 wing hinge, with Scer\GAL4rn-GAL4-13 nabEP13
Classical Alleles ( 12 )
For All Classical Alleles Show
Allele of nab Class Mutagen Stocks Known lesion nabA23 hypomorphic allele - genetic evidence 2 Yes nabG26 loss of function allele 1 Yes nabNP1316 1 -- nabNP3537 1 -- nab1600 0 Yes nabe310 loss of function allele 0 Yes nabEP13 P-element activity 0 Yes nabEP29 P-element activity 0 -- nabEP642 0 -- nabR52 loss of function allele Delta2-3 0 Yes nabSH143 loss of function allele P-element activity 0 -- nabunspecified 0 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of nab Class Mutagen Stocks Known lesion nabGD8511 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes nabGD1607 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes nabKK110447 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes nabdsRNA.CG15000.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes nabdsRNA.CG15001.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes nabScer\UAS.cCa in vitro construct - regulatory fusion 0 Yes nabScer\UAS.cFa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel6100 (Ryder, 2004.4.26) Df(3L)GN19 (Clements et al., 2003, Harrison et al., 1995) Df(3L)GN34 (Harrison et al., 1995) Df(3L)nab1600 (Clements et al., 2003) Df(3L)TE1 (Harrison et al., 1995)
Not disrupted in	Df(3L)C175 (Harrison et al., 1995) Df(3L)HR298 (Harrison et al., 1995)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1607} NA P{GD8511} NA P{KK110447} NA P{UAS-nab.C} NA P{UAS-nab.CG15000.RNAi} NA P{UAS-nab.CG15001.RNAi} NA P{UAS-nab.PF} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}nabe310 No P{lacW}nabSH143 No P{lacW}S148316a No insertion of enhancer trap binary system P{GawB}nabNP1316 No P{GawB}nabNP3537 No miscellaneous insertions P{SUPor-P}KG07676 NA insertion of mobile activating element P{EP}nabEP13 NA P{EP}nabEP29 NA P{EP}nabnd642 NA
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function
CV term Evidence References
transcription cofactor activity inferred from genetic interaction with rn (Félix et al., 2007) inferred from genetic interaction with sqz (Félix et al., 2007) inferred from mutant phenotype (Félix et al., 2007) inferred from physical interaction with rn (Félix et al., 2007) inferred from physical interaction with sqz (Félix et al., 2007)
Biological Process
CV term Evidence References
cell proliferation inferred from mutant phenotype (Suissa et al., 2011) locomotory behavior inferred from mutant phenotype (Clements et al., 2003) neuroblast development inferred from mutant phenotype (Tsuji et al., 2008) neuron development inferred from mutant phenotype (Félix et al., 2007) wing disc pattern formation inferred from mutant phenotype (Félix et al., 2007)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
transcription factor binding inferred from sequence or structural similarity with EMBL:U47543 (FlyBase, 1992-)
Biological Process
CV term Evidence References
negative regulation of transcription, DNA-dependent inferred from sequence or structural similarity with UniProtKB:Q62722 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with UniProtKB:Q62722 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions nab allele Gene References nabe310 mas (Clements et al., 2003)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0259986 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 3346237
Orthologs
Genome-wide drosophilid orthologs	Dana\GF23885 Dere\GG14216 Dgri\GH15553 Dmoj\GI16828 Dper\GL12736 Dpse\GA28207 Dsim\GD13289 Dvir\GJ12576 Dwil\GK10073 Dyak\GE20644
Curated drosophilid orthologs
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12267 PB12269 LH11058 ISCW016628 ISCW008024 FBgn0237949 FBgn0215956 FBgn0212088 FBgn0199816 FBgn0185008 FBgn0168937 FBgn0168938 FBgn0249570 FBgn0150342 FBgn0139575 FBgn0123024 FBgn0106477 FBgn0100879 CPIJ004303 BGIBMGA008666 ACYPI41460 AGAP002814 AAEL002112 PHUM567510 GLEAN_04602
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	5182 bw1; nabA23 st1/TM6B, Tb1 5183 bw1; nabG26 st1/TM6B, Tb1
Kyoto	108088 bw1; nabA23 st1/TM6B, Tb1 104533 w*; P{GawB}nabNP3537 / TM6, Sb1 Tb1 112622 y* w*; P{GawB}nabNP1316 / TM6, P{UAS-lacZ.UW23-1}UW23-1
VDRC	v104811 P{KK110447}VIE-260B v6273 w1118; P{GD1607}v6273 v24943 w1118; P{GD8511}v24943 v24944 w1118; P{GD8511}v24944 v39906 w1118; P{GD8511}v39906
Genomic Clones ( 1 )
	BACR48M07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 5 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP22227
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	79568 214345.15 EK209335 EP11719
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0259986 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38497 38498 3346237
Antibody Information
	polyclonal (Suissa et al., 2011)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: nab CG15000 CG15001 (Brody, 2004.4.27) Source for identity of: nab l(3)64Aj (Clements et al., 2003)
Source for database merge of	Source for merge of: CG15000 CG15001 (Brody, 2004.4.27) Source for merge of: l(3)SH143 nab (Félix et al., 2007)
Additional comments
Other Comments
	nab activity triggers apoptosis through the pro-apoptotic proteins rpr and W, which in turn reduce th protein levels, allowing Nc activation by Ark and subsequent activation of the effector caspases. (Suissa et al., 2011) Annotations CG15000 and CG15001 merged as CG33545 (which corresponds to nab) in release 4.1 of the genome annotation. (FlyBase Genome Annotators, 2005) 1 allele of l(3)SH143 recovered in a P-insertion screen. (Oh et al., 2003) Discussed during genetic analysis of the Ras64B-Rop region. (Harrison et al., 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001014557 NM_001169873 RefSeq (Proteins) • NP_001014557 NP_001163344 DDBJ / EMBL / GenBank • AAF47848.2 AAF47849.1 AAX52730 AB082911 ACZ94616 Entrez Gene - A searchable database of RefSeq genes. • 3346237
Other Crossreferences
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0259986 DRSC - Results from RNAi screens. • FBgn0259986 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259986 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0259986 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38497 38498 3346237 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/nab.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 3346237 modMine - Data generated by the modENCODE project. • FBgn0259986 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12267 PB12269 LH11058 ISCW016628 ISCW008024 FBgn0237949 FBgn0215956 FBgn0212088 FBgn0199816 FBgn0185008 FBgn0168937 FBgn0168938 FBgn0249570 FBgn0150342 FBgn0139575 FBgn0123024 FBgn0106477 FBgn0100879 CPIJ004303 BGIBMGA008666 ACYPI41460 AGAP002814 AAEL002112 PHUM567510 GLEAN_04602
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	CG15000 (Brody, 2004.4.27, Butler et al., 2003, Jacobsen et al., 2006, Nairz et al., 2004) CG15001 (Brody, 2004.4.27, Butler et al., 2003, Jacobsen et al., 2006) CG33545 (Keleman et al., 2009.8.5) dnab (Clements et al., 2003, Ziv et al., 2009) dNAB (Jacobsen et al., 2006) l(2)SH3 143 (Oh et al., 2002.3.26) l(3)64Aj (Harrison, 1999.5.12, ) l(3)SH21 (Harrison et al., 1995) l(3)SH143   nab (Baumgardt et al., 2009, Félix et al., 2007, Ulvklo et al., 2008, Baumgardt et al., 2008, Diaz-Benjumea, 2008.8.8, Tsuji et al., 2008, Terriente et al., 2008, Blard et al., 2007, Karlsson et al., 2010, Losada-Pérez et al., 2010) Nab (Perea et al., 2009) NAB (Suissa et al., 2011)
Name Synonym	lethal (3) SH143   nab (Karlsson et al., 2010)
Secondary FlyBase IDs
	FBgn0016012 FBgn0035502 FBgn0035503 FBgn0053545 FBgn0065124 FBgn0069097
References ( 35 )
Generate a list of	All references relating to this gene ( 35 )
List References by type	Research paper  ( 18 ) Supplementary material  ( 3 ) Review  ( 1 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 2 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 6 )
	Gabilondo et al., 2011, Mech. Dev. 128(3-4): 208--221 A targeted genetic screen identifies crucial players in the specification of the Drosophila abdominal Capaergic neurons. [FBrf0213290] Suissa et al., 2011, J. Biol. Chem. 286(17): 15556--15564 The NAB-Brk Signal Bifurcates at JNK to Independently Induce Apoptosis and Compensatory Proliferation. [FBrf0213516] Benito-Sipos et al., 2010, Development 137(19): 3327--3336 A genetic cascade involving klumpfuss, nab and castor specifies the abdominal leucokinergic neurons in the Drosophila CNS. [FBrf0211769] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Karlsson et al., 2010, PLoS Biol. 8(5): e1000368 Segment-specific neuronal subtype specification by the integration of anteroposterior and temporal cues. [FBrf0210822] Losada-Pérez et al., 2010, Mech. Dev. 127(9-12): 458--471 Lineage-unrelated neurons generated in different temporal windows and expressing different combinatorial codes can converge in the activation of the same terminal differentiation gene. [FBrf0212045] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...