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Gene Dana\Amy4N

General Information
Symbol	Dana\Amy4N	Species	D. ananassae
Name	α-Amylase 4N	Annotation symbol	GF13835
Feature type	protein_coding_gene	FlyBase ID	FBgn0259988
Gene Model Status	Current	Stock availability	None publicly available
Also Known As	AMY4, Dana\GF13835
Genomic Location
Chromosome (arm)	scaffold_13266	Recombination map	3-
Cytogenetic map		Sequence location	scaffold_13266:19,122,356..19,123,905 [+]
Genomic Maps	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene α-Amylase 4N is referred to in FlyBase by the symbol Dana\Amy4N (GF13835, FBgn0259988). It is a protein_coding_gene from Drosophila ananassae. Based on sequence similarity, it is predicted to have molecular function: alpha-amylase activity; calcium ion binding. Based on sequence similarity, it is predicted to be involved in the biological process: carbohydrate metabolic process. No alleles are reported. It has one annotated transcript and one annotated polypeptide. Protein features are: Alpha amylase; Alpha-amylase, C-terminal all beta; Glycoside hydrolase, catalytic domain; Glycoside hydrolase, family 13; Glycoside hydrolase, superfamily; Glycosyl hydrolase, family 13, all-beta; Glycosyl hydrolase, family 13, catalytic domain; Glycosyl hydrolase, family 13, subfamily, catalytic domain. Gene sequence location is scaffold_13266:19122356..19123905.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location
Experimentally Determined Cytological Location
Cytogenetic map Notes References   Maps to 81C.   (Da Lage et al., 2000)
Experimentally Determined Recombination Data
Location	3- (Da Lage, 1996.4.3)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dana\Amy4N for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Dana\Amy4N-RA FBtr0118535  XM_001961334   1488   495
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Dana\Amy4N-PA   FBpp0117027   53.8   495   6.64     XP_001961370   EDV38192
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Alpha amylase (IPR006046) Glycosyl hydrolase, family 13, catalytic domain (IPR006047) Alpha-amylase, C-terminal all beta (IPR006048) Glycosyl hydrolase, family 13, subfamily, catalytic domain (IPR006589) Glycosyl hydrolase, family 13, all-beta (IPR013780) Glycoside hydrolase, catalytic domain (IPR013781) Glycoside hydrolase, superfamily (IPR017853) Glycoside hydrolase, family 13 (IPR015902)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name U31121 AAC47352   U53477 AAC48343
UniProtKB/Swiss-Prot	Q23834
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
modENCODE Anatomy RNA-Seq
modENCODE Development RNA-Seq
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
Expression Clusters
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Dana\Amy4N Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 0 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Dana\Amy4N Class Mutagen Stocks Known lesion
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
alpha-amylase activity inferred from sequence or structural similarity with UniProtKB:P08144 (Da Lage et al., 2000) calcium ion binding inferred from sequence or structural similarity with UniProtKB:P08144 (Da Lage et al., 2000)
Biological Process
CV term Evidence References
carbohydrate metabolic process inferred from sequence or structural similarity with UniProtKB:P08144 (Da Lage et al., 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene   nuclear_gene (Drosophila 12 Genomes Consortium, 2008) protein_coding_gene (Drosophila 12 Genomes Consortium, 2008)
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Dana\Amy4N allele Gene References
External Data
Linkouts
Orthologs
OrthoDB Orthologs (2) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6W9JPN Dipteran inclusive ortholog search EOG6XKVGB Insect inclusive ortholog search EOG6WH7G1 Arthropod inclusive ortholog search EOG60VT4V Metazoa inclusive ortholog search EOG6677D6
Ortholog(s) in Drosophila melanogaster (EOG6W9JPN)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Amy-p     Drosophila melanogaster fruit fly  Dmel\Amy-d
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 0 )
Genomic Clones ( 0 )
cDNA Clones ( 0 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Dana\Amy4N Dana\Amy4 (Da Lage, 2001.1.24) Source for merge of: Dana\Amy4N Dana\GF13835 (Stanley, 2008.8.18)
Additional comments
Other Comments
	The expression of Dana\Amy4N in third instar larvae and adults has been investigated. (Da Lage et al., 1996) Dana\Amyi5 and Dana\Amy4N coding sequences are closely linked. (Da Lage et al., 1992)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • XM_001961334 RefSeq (Proteins) • XP_001961370 DDBJ / EMBL / GenBank • AAC47352 AAC48343 U31121 U53477 UniProtKB/Swiss-Prot • Q23834
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Alpha amylase (IPR006046) Glycosyl hydrolase, family 13, catalytic domain (IPR006047) Alpha-amylase, C-terminal all beta (IPR006048) Glycosyl hydrolase, family 13, subfamily, catalytic domain (IPR006589) Glycosyl hydrolase, family 13, all-beta (IPR013780) Glycoside hydrolase, catalytic domain (IPR013781) Glycoside hydrolase, superfamily (IPR017853) Glycoside hydrolase, family 13 (IPR015902)
Linkouts
	FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0259988
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	Amy (Moriwaki and Tobari, 1993) AMY4 (Da Lage, 2001.1.24, Da Lage et al., 2000) Amy4 (Tomimura et al., 1993) Amy 4N (Zhang and Kishino, 2004) Amy4N (Da Lage et al., 2000) dana_GLEANR_13842 (Drosophila 12 Genomes Consortium, 2008) Dana\Amy4   Dana\Amy4N (Stanley, 2008.8.18, ) Dana\GF13835 (Stanley, 2008.8.18, Drosophila 12 Genomes Consortium, 2008) GF13835 (Drosophila 12 Genomes Consortium, 2008)
Name Synonym	α-Amylase   α-Amylase 4N
Secondary FlyBase IDs
	FBgn0013780 FBgn0016146 FBgn0090862
References ( 14 )
Research paper	Drosophila 12 Genomes Consortium et al., 2007, Nature 450(7167): 203--218 Evolution of genes and genomes on the Drosophila phylogeny. [FBrf0200326] Zhang and Kishino, 2004, Mol. Biol. Evol. 21(2): 222--227 Genomic background drives the divergence of duplicated amylase genes at synonymous sites in Drosophila. [FBrf0174938] Da Lage et al., 2000, J. Mol. Evol. 51(4): 391--403 Molecular characterization and evolution of the amylase multigene family of Drosophila ananassae. [FBrf0129778] Miller et al., 2000, Mol. Biol. Evol. 17(11): 1597--1609 Evolutionary dynamics of the SGM transposon family in the Drosophila obscura species group. [FBrf0131362] Da Lage et al., 1998, Proc. Natl. Acad. Sci. U.S.A. 95(12): 6848--6853 Amyrel, a paralogous gene of the amylase gene family in Drosophila melanogaster and the Sophophora subgenus. [FBrf0102910] Da Lage et al., 1996, Heredity 76(1): 9--18 Variation in sex-, stage- and tissue-specific expression of the amylase genes in Drosophila ananassae. [FBrf0084923] Da Lage et al., 1996, J. Mol. Evol. 43(4): 334--347 Distribution and evolution of introns in Drosophila amylase genes. [FBrf0090513] Da Lage et al., 1992, Genet. Res. (Camb.) 59(2): 85--92 Multiple amylase genes in Drosophila ananassae and related species. [FBrf0056160]
Review	Moriwaki and Tobari, 1993, Tobari, 1993: 209--259 Catalog of mutants. [FBrf0063720] Tomimura et al., 1993, Tobari, 1993: 139--198 Population genetics. [FBrf0063921]
Personal communication to FlyBase	Drosophila 12 Genomes Consortium, 2008, personal communication to FlyBase Symbols and class of gene information for the GLEANR consensus sequences of the 11 sequenced non-melanogaster Drosophila species (Drosophila ananassae, erecta, grimshawi, mojavensis, persimilis, pseudoobscura, sechellia, simulans, willistoni, virilis and yakuba). [FBrf0202436] Stanley, 2008.8.18, Merge of DanaGF13835 and DanaAmy4N. Merge of Dana\GF13835 and Dana\Amy4N. [FBrf0205598] Da Lage, 2001.1.24, AF238900 - AF238977. AF238900 - AF238977. [FBrf0133275]
DNA/RNA sequence record	Da Lage, 1996.4.3, GenBank/EMBL/DDBJ: U53477 Drosophila ananassae alpha-amylase (Amy4N) gene, complete cds. [FBrf0114329]