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Gene Dmel\Dys

General Information
Symbol	Dmel\Dys	Species	D. melanogaster
Name	Dystrophin	Annotation symbol	CG34157
Feature type	protein_coding_gene	FlyBase ID	FBgn0260003
Gene Model Status	Current	Stock availability	32 publicly available
Also Known As	det, DLP2, Dp205, CG31175, dmDLP, CG7243, DLP3, DLP1, CG7240, DmDYS
Genomic Location
Chromosome (arm)	3R	Recombination map	3-72.5
Cytogenetic map	92A5-92A10	Sequence location	3R:15,286,810..15,421,117 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Dystrophin is referred to in FlyBase by the symbol Dmel\Dys (CG34157, FBgn0260003). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: WW domain binding. There is experimental evidence that it is involved in the biological process: neuromuscular synaptic transmission; regulation of neurotransmitter secretion; imaginal disc-derived wing vein morphogenesis; imaginal disc-derived wing vein specification; regulation of short-term neuronal synaptic plasticity; muscle cell homeostasis; establishment of cell polarity. 56 alleles are reported. The phenotypes of these alleles are annotated with: posterior crossvein; t-bar; presynaptic active zone; oocyte; terminal button; neuromuscular junction; eye photoreceptor cell; indirect flight muscle. It has 8 annotated transcripts and 8 annotated polypeptides. Protein features are: Actinin-type, actin-binding, conserved site; Calponin homology domain; EF-hand domain, type 1; EF-hand domain, type 2; EF-hand-like domain; Spectrin repeat; Spectrin/alpha-actinin; WW/Rsp5/WWP; Zinc finger, ZZ-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 12-18 embryonic stages, during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult crop, larval midgut, larval/adult hindgut, larval Malpighian tubules, larval salivary gland, adult spermathecae. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult midgut, adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval/adult carcass. Gene sequence location is 3R:15286810..15421117.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	det: detached det: detached From Bridges and Brehme, 1944, Carnegie Inst. Washington Publ. No. 552: 54. Posterior crossveins detached from longitudinals at one or both ends and may be absent. Wings occasionally folded back under or folded flat at middle. Eyes sometimes rough and bulging. Wings slightly spread. Bristles tend to break; scutellars occasionally doubled. RK3.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Alleles Dys[MI03993] Insertions Mi{MIC}Dys[MI03993] References Bellen, 2011.10.10, MISet953.xml Knowles-Barley, 2011.8.24, BrainTrap expression curation.
FB2012_01	References Bellen, 2011.11.10, set958.xml Mosqueira et al., 2010, PLoS ONE 5(10): e13450 Bellen, 2011.10.25, set956.xml Alleles Dys[MI02876] Dys[MI01893] Dys[MI00812] Insertions Mi{MIC}Dys[MI00812] Mi{MIC}Dys[MI01893] Mi{MIC}Dys[MI02876] Sequence features HFA16935 BKN31661 HFA15260 BKN33640 BKN21336 HFA13364 HFA16218 HFA13360 HFA16219 HFA16220
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 92A5-92A10   Limits computationally determined from genome sequence between P{EP}EP650 and P{PZ}l(3)1058510585
Experimentally Determined Cytological Location
Cytogenetic map Notes References 91F-92A   (determined by in situ hybridisation)   (Neuman et al., 2001) 92A6-92A7     (Greener, 2000.6.14)
Experimentally Determined Recombination Data
Location	3-67 (Christoforou et al., 2008) 3-72.5
Left of (cM)	e (Christoforou et al., 2008)
Right of (cM)
Notes	det has been mapped by recombination to approximately 3-67, in contrast to the previously reported position of 3-72.5 (in agreement with this, all deficiencies covering the 72.5cM recombination position complement det mutations). (Christoforou et al., 2008)
Gene Model & Products
Please see the GBrowse view of Dmel\Dys for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene merge based on EST/cDNA data; merge with CG7344 based on GB:BT010020.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Dys-RA FBtr0083764  NM_001043258   11000   3497 Dys-RB FBtr0083766  NM_001043256   5153   1669 Dys-RC FBtr0083765  NM_001043259   10554   3127 Dys-RD FBtr0110915  NM_001043260   6600   1854 Dys-RE FBtr0110916  NM_001043262   4529   1051 Dys-RF FBtr0110917  NM_001043263   11588   3529 Dys-RG FBtr0110918  NM_001043261   11377   3504 Dys-RH FBtr0110919  NM_001043257   11967   3598
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Dys-PA   FBpp0083178   399.4   3497   5.09     NP_001036723   AAF55673 Dys-PB   FBpp0083180   185.3   1669   7.05     NP_001036721   AAF55676 Dys-PC   FBpp0083179   358.1   3127   5.27     NP_001036724   AAF55675 Dys-PD   FBpp0110215   205.7   1854   7.61     NP_001036725   ABI31177 Dys-PE   FBpp0110216   116.7   1051   5.48     NP_001036727   ABI31179 Dys-PF   FBpp0110217   403.2   3529   5.05     NP_001036728   ABI31180 Dys-PG   FBpp0110218   400.2   3504   5.11     NP_001036726   ABI31178 Dys-PH   FBpp0110219   410.4   3598   5.16     NP_001036722   ABI31176
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, ZZ-type (IPR000433) WW/Rsp5/WWP (IPR001202) Actinin-type, actin-binding, conserved site (IPR001589) Calponin homology domain (IPR001715) Spectrin repeat (IPR002017) EF-hand-like domain (IPR011992) EF-hand domain, type 1 (IPR015153) EF-hand domain, type 2 (IPR015154) Spectrin/alpha-actinin (IPR018159)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA392372   AA697872   AE014297 AAF55673   AE014297 AAF55675   AE014297 AAF55676   AE014297 ABI31176   AE014297 ABI31177   AE014297 ABI31178   AE014297 ABI31179   AE014297 ABI31180   AC008192   AF277386 AAG17395   AF297644 AAK15256   AF300294 AAK15257   AF300456 AAK15258   AF302236 AAK18176   AI531887   AI534705   AY875639 AAX59985   BF500832   BG636373   BG639852   BI170096   BI367633   BI375923   BT010020 AAQ22489   BT029673   CO178026   CO189432   CO266178   CO270373   CO279611   CO283100   CO292600   CO294109   CO298610   CO306957   CO313846   CO314349   CO320121   CO325061   CO327807   CO329020   CO337008   CO339683   CO340613   CO341952   CO343090   CZ470227   CZ470261   CZ473288   CZ473289   CZ476732   CZ478357   CZ478358   CZ481315   CZ482958   CZ483030   CZ483540   CZ488484   EC063377   EC066168   EC067128   EC069732   EC072241   EC073015   EC085082   EC202315   EC202762   EC204460   EC208767   EC214678   EC218149   EC220139   EC224357   EC235586   EC240666   EC243619   EC243889   EC250265   EC251849   EC252370   EC252812   EC252852   EC254116   EC254778   EC255471   EC258192   EC262398   EG974133   X99757 CAA68088
UniProtKB/Swiss-Prot	Q9VDW3 Q9VDW6 Q7YU29 Q0KI50
UniProtKB/TrEMBL	Q7YU29
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 12   posterior midgut primordium   (Neuman et al., 2001) Comment:long isoform-specific anterior midgut primordium   (Neuman et al., 2001) Comment:long isoform-specific embryonic stage 16   embryonic/larval pericardial cell   (Neuman et al., 2001) Comment:long isoform-specific ectoderm | segment boundary   (Neuman et al., 2001) Comment:long isoform-specific ventral midline   (Neuman et al., 2001) Comment:long isoform-specific embryonic/larval central nervous system   (Neuman et al., 2001) Comment:short isoform-specific third instar larval stage   ventral nerve cord | restricted   (van der Plas et al., 2006) embryonic/larval brain | restricted   (van der Plas et al., 2006) eye-antennal disc | restricted   (van der Plas et al., 2006)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   embryonic/larval neuromuscular junction | subset   • postsynaptic membrane (van der Plas et al., 2006) embryonic/larval somatic muscle | subset   • sarcomere (van der Plas et al., 2006) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0260003    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0260003 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 12-18 embryonic stages, during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0260003 expression level Developmental Stage   Expression Level embryo 00-02hr    759 embryo 02-04hr    741 embryo 04-06hr    231 embryo 06-08hr    352 embryo 08-10hr    654 embryo 10-12hr    898 embryo 12-14hr    1610 embryo 14-16hr    2127 embryo 16-18hr    1671 embryo 18-20hr    1259 embryo 20-22hr    1154 embryo 22-24hr    1074 larva L1    682 larva L2    513 larva L3 12hr old    483 larva L3 puffstage 1-2    363 larva L3 puffstage 3-6    818 larva L3 puffstage 7-9    824 white prepupae new    1019 white prepupae 12hr    1384 white prepupae 24hr    1353 pupae 2d postWPP    1570 pupae 3d postWPP    877 pupae 4d postWPP    670 adult male 01day    646 adult male 05day    757 adult male 30day    722 adult female 01day    694 adult female 05day    809 adult female 30day    826 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (759) embryo 02-04hr  (741) embryo 04-06hr  (231) embryo 06-08hr  (352) embryo 08-10hr  (654) embryo 10-12hr  (898) embryo 12-14hr  (1610) embryo 14-16hr  (2127) embryo 16-18hr  (1671) embryo 18-20hr  (1259) embryo 20-22hr  (1154) embryo 22-24hr  (1074) larva L1  (682) larva L2  (513) larva L3 12hr old  (483) larva L3 puffstage 1-2  (363) larva L3 puffstage 3-6  (818) larva L3 puffstage 7-9  (824) white prepupae new  (1019) white prepupae 12hr  (1384) white prepupae 24hr  (1353) pupae 2d postWPP  (1570) pupae 3d postWPP  (877) pupae 4d postWPP  (670) adult male 01day  (646) adult male 05day  (757) adult male 30day  (722) adult female 01day  (694) adult female 05day  (809) adult female 30day  (826) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    759 embryo 02-04hr    741 embryo 04-06hr    231 embryo 06-08hr    352 embryo 08-10hr    654 embryo 10-12hr    898 embryo 12-14hr  (1610) embryo 14-16hr  (2127) embryo 16-18hr  (1671) embryo 18-20hr    1259 embryo 20-22hr    1154 embryo 22-24hr    1074 larva L1    682 larva L2    513 larva L3 12hr old    483 larva L3 puffstage 1-2    363 larva L3 puffstage 3-6    818 larva L3 puffstage 7-9    824 white prepupae new    1019 white prepupae 12hr    1384 white prepupae 24hr    1353 pupae 2d postWPP  (1570) pupae 3d postWPP    877 pupae 4d postWPP    670 adult male 01day    646 adult male 05day    757 adult male 30day    722 adult female 01day    694 adult female 05day    809 adult female 30day    826 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    759 embryo 02-04hr    741 embryo 04-06hr    231 embryo 06-08hr    352 embryo 08-10hr    654 embryo 10-12hr    898 embryo 12-14hr    1610 embryo 14-16hr    2127 embryo 16-18hr    1671 embryo 18-20hr    1259 embryo 20-22hr    1154 embryo 22-24hr    1074 larva L1    682 larva L2    513 larva L3 12hr old    483 larva L3 puffstage 1-2    363 larva L3 puffstage 3-6    818 larva L3 puffstage 7-9    824 white prepupae new    1019 white prepupae 12hr    1384 white prepupae 24hr    1353 pupae 2d postWPP    1570 pupae 3d postWPP    877 pupae 4d postWPP    670 adult male 01day    646 adult male 05day    757 adult male 30day    722 adult female 01day    694 adult female 05day    809 adult female 30day    826 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    759 embryo 02-04hr    741 embryo 04-06hr    231 embryo 06-08hr    352 embryo 08-10hr    654 embryo 10-12hr    898 embryo 12-14hr    1610 embryo 14-16hr    2127 embryo 16-18hr    1671 embryo 18-20hr    1259 embryo 20-22hr    1154 embryo 22-24hr    1074 larva L1    682 larva L2    513 larva L3 12hr old    483 larva L3 puffstage 1-2    363 larva L3 puffstage 3-6    818 larva L3 puffstage 7-9    824 white prepupae new    1019 white prepupae 12hr    1384 white prepupae 24hr    1353 pupae 2d postWPP    1570 pupae 3d postWPP    877 pupae 4d postWPP    670 adult male 01day    646 adult male 05day    757 adult male 30day    722 adult female 01day    694 adult female 05day    809 adult female 30day    826 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0260003 expression level Developmental Stage   Expression Level embryo 00-02hr    759 embryo 02-04hr    741 embryo 04-06hr    231 embryo 06-08hr    352 embryo 08-10hr    654 embryo 10-12hr    898 embryo 12-14hr    1610 embryo 14-16hr    2127 embryo 16-18hr    1671 embryo 18-20hr    1259 embryo 20-22hr    1154 embryo 22-24hr    1074 larva L1    682 larva L2    513 larva L3 12hr old    483 larva L3 puffstage 1-2    363 larva L3 puffstage 3-6    818 larva L3 puffstage 7-9    824 white prepupae new    1019 white prepupae 12hr    1384 white prepupae 24hr    1353 pupae 2d postWPP    1570 pupae 3d postWPP    877 pupae 4d postWPP    670 adult male 01day    646 adult male 05day    757 adult male 30day    722 adult female 01day    694 adult female 05day    809 adult female 30day    826 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (759) embryo 02-04hr  (741) embryo 04-06hr  (231) embryo 06-08hr  (352) embryo 08-10hr  (654) embryo 10-12hr  (898) embryo 12-14hr  (1610) embryo 14-16hr  (2127) embryo 16-18hr  (1671) embryo 18-20hr  (1259) embryo 20-22hr  (1154) embryo 22-24hr  (1074) larva L1  (682) larva L2  (513) larva L3 12hr old  (483) larva L3 puffstage 1-2  (363) larva L3 puffstage 3-6  (818) larva L3 puffstage 7-9  (824) white prepupae new  (1019) white prepupae 12hr  (1384) white prepupae 24hr  (1353) pupae 2d postWPP  (1570) pupae 3d postWPP  (877) pupae 4d postWPP  (670) adult male 01day  (646) adult male 05day  (757) adult male 30day  (722) adult female 01day  (694) adult female 05day  (809) adult female 30day  (826) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    759 embryo 02-04hr    741 embryo 04-06hr    231 embryo 06-08hr    352 embryo 08-10hr    654 embryo 10-12hr    898 embryo 12-14hr  1610 embryo 14-16hr  2127 embryo 16-18hr  1671 embryo 18-20hr    1259 embryo 20-22hr    1154 embryo 22-24hr    1074 larva L1    682 larva L2    513 larva L3 12hr old    483 larva L3 puffstage 1-2    363 larva L3 puffstage 3-6    818 larva L3 puffstage 7-9    824 white prepupae new    1019 white prepupae 12hr    1384 white prepupae 24hr    1353 pupae 2d postWPP  1570 pupae 3d postWPP    877 pupae 4d postWPP    670 adult male 01day    646 adult male 05day    757 adult male 30day    722 adult female 01day    694 adult female 05day    809 adult female 30day    826 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    759 embryo 02-04hr    741 embryo 04-06hr    231 embryo 06-08hr    352 embryo 08-10hr    654 embryo 10-12hr    898 embryo 12-14hr    1610 embryo 14-16hr    2127 embryo 16-18hr    1671 embryo 18-20hr    1259 embryo 20-22hr    1154 embryo 22-24hr    1074 larva L1    682 larva L2    513 larva L3 12hr old    483 larva L3 puffstage 1-2    363 larva L3 puffstage 3-6    818 larva L3 puffstage 7-9    824 white prepupae new    1019 white prepupae 12hr    1384 white prepupae 24hr    1353 pupae 2d postWPP    1570 pupae 3d postWPP    877 pupae 4d postWPP    670 adult male 01day    646 adult male 05day    757 adult male 30day    722 adult female 01day    694 adult female 05day    809 adult female 30day    826 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    759 embryo 02-04hr    741 embryo 04-06hr    231 embryo 06-08hr    352 embryo 08-10hr    654 embryo 10-12hr    898 embryo 12-14hr    1610 embryo 14-16hr    2127 embryo 16-18hr    1671 embryo 18-20hr    1259 embryo 20-22hr    1154 embryo 22-24hr    1074 larva L1    682 larva L2    513 larva L3 12hr old    483 larva L3 puffstage 1-2    363 larva L3 puffstage 3-6    818 larva L3 puffstage 7-9    824 white prepupae new    1019 white prepupae 12hr    1384 white prepupae 24hr    1353 pupae 2d postWPP    1570 pupae 3d postWPP    877 pupae 4d postWPP    670 adult male 01day    646 adult male 05day    757 adult male 30day    722 adult female 01day    694 adult female 05day    809 adult female 30day    826 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0260003    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0260003 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult crop, larval midgut, larval/adult hindgut, larval Malpighian tubules, larval salivary gland, adult spermathecae. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult midgut, adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_27
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0260003
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Dysc07024 viable, with Scer\GAL4pnr-MD237 DysGD8862 viable (with Df(3R)Exel6184) DysEP3397 Sterility Allele fertile Dysc07024 Other Phenotypes Allele cell polarity defective, with Scer\GAL4mat.αTub67C.T:Hsim\VP16 DysdsRNA.N.Scer\UAS.P\T cell polarity defective (with Df(3R)Dl-X43) Dys8-2 DysE6 locomotor behavior defective | adult stage | conditional, with Scer\GAL4how-24B DysdsRNA.C.Scer\UAS DysdsRNA.N.Scer\UAS DysdsRNA.RB.Scer\UAS locomotor behavior defective | adult stage | conditional, with Scer\GAL4tub.PU DysdsRNA.C.Scer\UAS DysdsRNA.N.Scer\UAS DysdsRNA.RB.Scer\UAS locomotor behavior defective | adult stage | conditional (with Df(3R)Dl-X43) Dys8-2 neuroanatomy defective, with Scer\GAL4tub.PU DysdsRNA.C.Scer\UAS neuroanatomy defective | third instar larval stage, with Scer\GAL4GMR.PU DysdsRNA.C.Scer\UAS DysdsRNA.N.Scer\UAS DysdsRNA.RB.Scer\UAS neuroanatomy defective | third instar larval stage, with Scer\GAL4repo.PU DysdsRNA.C.Scer\UAS DysdsRNA.N.Scer\UAS DysdsRNA.RB.Scer\UAS neuroanatomy defective | third instar larval stage (with Df(3R)Dl-X43) Dys8-2 neuroanatomy defective | third instar larval stage (with Dys8-2) DysE6 neuroanatomy defective | third instar larval stage (with DysE6) Dys8-2 neurophysiology defective DysDp186.30.3 DysDp186.166.3 DysE6 DysGE20705 neurophysiology defective, with Scer\GAL4B19 DysdsRNA.mub.Scer\UAS neurophysiology defective, with Scer\GAL4eve.RN2 DysdsRNA.mub.Scer\UAS DysF.Dp186.Scer\UAS neurophysiology defective, with Scer\GAL4G14 DysdsRNA.NH2.Scer\UAS neurophysiology defective, with Scer\GAL4how-24B DysdsRNA.NH2.Scer\UAS neurophysiology defective (with DysE6) DysGE20705 neurophysiology defective (with DysGE20705) DysE6 neurophysiology defective | dominant DysE6 visible Dysdet-1 visible (with Df(3R)Exel6184) Dysdet-1 visible (with Df(3R)Exel6184), with Scer\GAL4[-]: DysEP3397 visible (with Dysdet-1) DysE6 visible (with Dysdet-1), with Scer\GAL4[-]: DysEP3397 visible (with DysE6) Dysdet-1 visible (with DysEP3397), with Scer\GAL4[-]: Dysdet-1 visible | recessive DysE6 Phenotype manifest in Allele egg | maternal effect (with Df(3R)Exel6184) DysE17 epithelial glial cell | third instar larval stage, with Scer\GAL4tub.PU DysdsRNA.C.Scer\UAS eye disc | third instar larval stage, with Scer\GAL4GMR.PU DysdsRNA.N.Scer\UAS DysdsRNA.C.Scer\UAS DysdsRNA.RB.Scer\UAS eye disc | third instar larval stage, with Scer\GAL4repo.PU DysdsRNA.N.Scer\UAS DysdsRNA.C.Scer\UAS DysdsRNA.RB.Scer\UAS eye disc | third instar larval stage, with Scer\GAL4tub.PU DysdsRNA.C.Scer\UAS eye disc | third instar larval stage (with Df(3R)Dl-X43) Dys8-2 eye disc | third instar larval stage (with Dys8-2) DysE6 eye disc | third instar larval stage (with DysE6) Dys8-2 eye photoreceptor cell, with Scer\GAL4how-24B DysdsRNA.C.Scer\UAS eye photoreceptor cell (with Df(3R)Dl-X43) Dys8-2 eye photoreceptor cell | third instar larval stage, with Scer\GAL4GMR.PU DysdsRNA.N.Scer\UAS DysdsRNA.C.Scer\UAS DysdsRNA.RB.Scer\UAS eye photoreceptor cell | third instar larval stage, with Scer\GAL4repo.PU DysdsRNA.N.Scer\UAS DysdsRNA.C.Scer\UAS DysdsRNA.RB.Scer\UAS eye photoreceptor cell | third instar larval stage (with Df(3R)Dl-X43) Dys8-2 eye photoreceptor cell | third instar larval stage (with Dys8-2) DysE6 eye photoreceptor cell | third instar larval stage (with DysE6) Dys8-2 hemocyte | pupal stage (with Df(3R)Exel6184) DysEP3397 indirect flight muscle, with Scer\GAL4tub.PU DysdsRNA.RB.Scer\UAS indirect flight muscle | conditional, with Scer\GAL4how-24B DysdsRNA.N.Scer\UAS indirect flight muscle | conditional, with Scer\GAL4tub.PU DysdsRNA.N.Scer\UAS indirect flight muscle | conditional (with Df(3R)Dl-X43) Dys8-2 lamina plexus | third instar larval stage, with Scer\GAL4GMR.PU DysdsRNA.N.Scer\UAS DysdsRNA.C.Scer\UAS DysdsRNA.RB.Scer\UAS lamina plexus | third instar larval stage, with Scer\GAL4repo.PU DysdsRNA.N.Scer\UAS DysdsRNA.C.Scer\UAS DysdsRNA.RB.Scer\UAS lamina plexus | third instar larval stage, with Scer\GAL4tub.PU DysdsRNA.C.Scer\UAS lamina plexus | third instar larval stage (with Df(3R)Dl-X43) Dys8-2 lamina plexus | third instar larval stage (with Dys8-2) DysE6 lamina plexus | third instar larval stage (with DysE6) Dys8-2 marginal glial cell | third instar larval stage, with Scer\GAL4tub.PU DysdsRNA.C.Scer\UAS neuromuscular junction DysE6 oocyte, with Scer\GAL4mat.αTub67C.T:Hsim\VP16 DysdsRNA.N.Scer\UAS.P\T oocyte (with Df(3R)Dl-X43) DysE6 Dys8-2 posterior crossvein Dysdet-1 DysE6 posterior crossvein (with Df(3R)Exel6184) Dysdet-1 posterior crossvein (with Df(3R)Exel6184), with Scer\GAL4[-]: DysEP3397 posterior crossvein (with Dysdet-1) DysE6 posterior crossvein (with Dysdet-1), with Scer\GAL4[-]: DysEP3397 posterior crossvein (with DysE6) Dysdet-1 posterior crossvein (with DysEP3397), with Scer\GAL4[-]: Dysdet-1 presynaptic active zone DysE6 DysGE20705 t-bar DysE6 terminal button DysE6 DysGE20705
Classical Alleles ( 39 )
For All Classical Alleles Show
Allele of Dys Class Mutagen Stocks Known lesion Dysc07024 piggyBac transposase 2 -- Dysdet-1 hypomorphic allele - genetic evidence spontaneous 2 -- DysEP3397 amorphic allele - genetic evidence P-element activity 1 Yes Dysc05798 piggyBac transposase 1 -- Dysd00360 1 -- Dysd03320 P-element activity 1 -- Dysd07105 1 -- Dysd09416 P-element activity 1 -- Dyse00473 piggyBac transposase 1 -- Dyse03558 piggyBac transposase 1 -- DysEY08889 1 -- Dysf00491 piggyBac transposase 1 -- Dysf00572 piggyBac transposase 1 -- Dysf00715 1 -- Dysf01051 piggyBac transposase 1 -- Dysf01145 1 -- Dysf05865 piggyBac transposase 1 -- DysMB01222 1 -- DysMB01698 1 -- DysMB02524 1 -- DysMB03186 1 -- DysMB08490 1 -- DysMI03993 1 -- DysE17 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Dys8-2 P-element activity 0 Yes Dysc05751 piggyBac transposase 0 -- DysCPTI002256 piggyBac transposase 0 Yes DysCPTI003818 piggyBac transposase 0 Yes Dysd01369 0 -- Dysd01926 0 -- Dysd05905 0 -- DysDp186.166.3 P-element activity 0 Yes DysDp186.30.3 P-element activity 0 Yes DysE6 P-element activity 0 Yes DysGE20705 0 Yes DysGS12472 0 -- DysMI00812 0 -- DysMI01893 0 -- DysMI02876 0 --
Alleles Carried on Transgenic Constructs ( 17 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Dys Class Mutagen Stocks Known lesion DysGD16183 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes DysGD8862 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes DysJF01118 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes DysKK101285 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes DysKK111661 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes DysKK113640 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes DysDp186.Scer\UAS in vitro construct - regulatory fusion 0 Yes DysdsRNA.C.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes DysdsRNA.cMa in vitro construct - RNAi 0 -- DysdsRNA.mub.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes DysdsRNA.N.Scer\UAS.P\T in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes DysdsRNA.N.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes DysdsRNA.NH2.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes DysdsRNA.RB.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes DysdsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes DysF.Dp186.Scer\UAS in vitro construct - regulatory fusion 0 Yes DysGD5162 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)DysE6 (van der Plas et al., 2006) Df(3R)Exel6184 (Ryder, 2004.4.26, Wolf et al., 2006, Christoforou et al., 2008, Fradkin et al., 2008)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5162} NA P{GD8862} NA P{GD16183} NA P{KK101285} NA P{KK111661} NA P{KK113640} NA P{TRiP.JF01118} NA P{UAS-Dp186} NA P{UAS-Dys.Dp186} NA P{UAS-Dys.dsRNA} NA P{UASp-Dys-Dp186.dsRNA} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}DysEP3397 NA P{EP}DysGE20705 NA P{EPgy2}DysEY08889 NA P{GSV1}DysGS12472 NA P{XP}Dysd00360 NA P{XP}Dysd01369 NA P{XP}Dysd01926 NA P{XP}Dysd03320 NA P{XP}Dysd05905 NA P{XP}Dysd07105 NA P{XP}Dysd09416 NA miscellaneous insertions Mi{MIC}DysMI00812 NA Mi{MIC}DysMI01893 NA Mi{MIC}DysMI02876 NA Mi{MIC}DysMI03993 NA PBac{681.P.FSVS-1}DysCPTI002256 NA PBac{803.P.SVS-0}DysCPTI003818 NA PBac{PB}Dysc05751 NA PBac{PB}Dysc05798 NA PBac{PB}Dysc07024 NA PBac{RB}Dyse00473 NA PBac{RB}Dyse03558 NA PBac{WH}Dysf00491 NA PBac{WH}Dysf00572 NA PBac{WH}Dysf00715 NA PBac{WH}Dysf01051 NA PBac{WH}Dysf01145 NA PBac{WH}Dysf05865 NA insertion of enhancer trap binary system Mi{ET1}DysMB01222 No Mi{ET1}DysMB01698 No Mi{ET1}DysMB02524 No Mi{ET1}DysMB03186 No Mi{ET1}DysMB08490 No
Gene Ontology: Function, Process & Cellular Component ( 18 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function
CV term Evidence References
WW domain binding inferred from physical interaction with Dg (Shcherbata et al., 2007)
Biological Process
CV term Evidence References
establishment of cell polarity inferred from mutant phenotype (Shcherbata et al., 2007) imaginal disc-derived wing vein morphogenesis inferred from mutant phenotype (Sturtevant and Bier, 1995, Pilgram et al., 2011) imaginal disc-derived wing vein specification inferred from mutant phenotype (Christoforou et al., 2008) muscle cell homeostasis inferred from mutant phenotype (Shcherbata et al., 2007) neuromuscular synaptic transmission inferred from direct assay (van der Plas et al., 2006) regulation of neurotransmitter secretion inferred from direct assay (Fradkin et al., 2008) regulation of short-term neuronal synaptic plasticity inferred from direct assay (van der Plas et al., 2006)
Cellular Component
CV term Evidence References
dystrophin-associated glycoprotein complex inferred from physical interaction with Dg (Yatsenko et al., 2007)
Terms Based on Predictions or Assertions ( 10 terms )
Molecular Function
CV term Evidence References
actin binding inferred from sequence or structural similarity (Roper et al., 2002) inferred from sequence or structural similarity with UniProtKB:P11532 (assigned by UniProtKB) (Swiss-Prot Project Members, 2004.6.15, Swiss-Prot Project Members, 2004.6.15) calcium ion binding inferred from electronic annotation with InterPro:IPR011992 (FlyBase Curators et al., 2004-) cytoskeletal protein binding inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) structural constituent of cytoskeleton inferred from sequence or structural similarity with UniProtKB:P11532 (assigned by UniProtKB) (Swiss-Prot Project Members, 2004.6.15, Swiss-Prot Project Members, 2004.6.15) structural constituent of muscle inferred from sequence or structural similarity with human DMD AND inferred from sequence or structural similarity with human DRP2 AND inferred from sequence or structural similarity with human UTRN (Greener and Roberts, 2000) inferred from sequence or structural similarity with UniProtKB:P11532 (assigned by UniProtKB) (Swiss-Prot Project Members, 2004.6.15, Swiss-Prot Project Members, 2004.6.15) structural molecule activity inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) zinc ion binding inferred from electronic annotation with InterPro:IPR000433 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
muscle organ development inferred from sequence or structural similarity with UniProtKB:P11532 (assigned by UniProtKB) (Swiss-Prot Project Members, 2004.6.15, Swiss-Prot Project Members, 2004.6.15)
Cellular Component
CV term Evidence References
cytoskeleton inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) inferred from sequence or structural similarity with UniProtKB:P11532 (assigned by UniProtKB) (Swiss-Prot Project Members, 2004.6.15, Swiss-Prot Project Members, 2004.6.15) dystrophin-associated glycoprotein complex inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) inferred from sequence or structural similarity with human DMD AND inferred from sequence or structural similarity with human DRP2 AND inferred from sequence or structural similarity with human UTRN (Greener and Roberts, 2000) inferred from sequence or structural similarity with UniProtKB:P11532 (assigned by UniProtKB) (Swiss-Prot Project Members, 2004.6.15, Swiss-Prot Project Members, 2004.6.15) non-traceable author statement (Greener, 2000.6.14)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Dys allele Gene References det1 dpp (Yu et al., 1996) unspecified rho (Sturtevant and Bier, 1995)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67322 DroID - A comprehensive database of gene and protein interactions. • FBgn0260003 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42327
Orthologs
Genome-wide drosophilid orthologs	Dana\GF16554
Curated drosophilid orthologs	Dpse\Dys (Burnette, 2005) Dpse\GA16065   Dpse\GA30238
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • XP_001943041.1 Acyrthosiphon pisum (pea aphid) ENSBTAP00000012740 Bos taurus (bovine) CN29324 Caenorhabditis brenneri (small nematode) CE27129 Caenorhabditis elegans (worm) ENSCAFP00000000453 Canis familiaris (dog) JA11377 Caenorhabditis japonica (nematode) CPIJ013032 Culex pipens (mosquito) ENSCPOP00000000752 Cavia porcellus (guinea pig) RP39670 Caenorhabditis remanei (nematode) 160045 Capitella spl (polychaete worm) ENSECAP00000018392 Equus caballus (horse) ENSGACP00000020025 Gymnopilus aculeatus (mushroom) ENSGALP00000026200 Gallus gallus (chicken) ENSP00000354923 Homo sapiens (human) 169302 Lottia gigantea (owl limpet) ENSMODP00000021501 Monodelphis domestica (gray opossum) ENSMMUP00000025426 Macaca mulatta (rhesus monkey) ENSMUSP00000109633 Mus musculus (house mouse) ENSOANP00000017265 Ornithorynchus anatinus (platypus) ENSORLP00000025562 Oryzias latipes (japanese killifish) PHUM004359-PA Pediculus humanus (human body louse) PP26528 Pristionchus pacificus (nematode) ENSPPYP00000022629 Pongo pygmaeus (orangutan) ENSPTRP00000047461 Pan troglodytes (chimpanzee) ENSRNOP00000029969 Rattus norvegicus (norway rat) Smp_076500 Schistosoma mansoni (trematode parasite) NP_999661.1 Strongylocentrotus purpuratus (purple sea urchin) ENSTNIP00000015226 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000046695 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000048228 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV50088 LH19855 ISCW001113 FBgn0242670 FBgn0215824 FBgn0209830 FBgn0190797 FBgn0186841 FBgn0175131 JGI_V11_94977 FBgn0248946 FBgn0150260 FBgn0145831 FBgn0129756 FBgn0115490 FBgn0093575 CPIJ013032 BGIBMGA008637 ACYPI005709 GB11865 PB19849 PHUM253810
Stocks & Reagents
Stocks Listed in FlyBase ( 32 )
Bloomington	477 Dysdet-1
Harvard	- P{XP}Dysd00360 - P{XP}Dysd03320 - P{XP}Dysd07105 - P{XP}Dysd09416 - PBac{PB}Dysc05798 - PBac{PB}Dysc07024 - PBac{RB}Dyse00473
Kyoto	105932 Dysdet-1
VDRC	v106401 P{KK111661}VIE-260B v106578 P{KK113640}VIE-260B v108006 P{KK101285}VIE-260B
	More stocks available...
Genomic Clones ( 2 )
	BACR07I18 BACR12P10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 59 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE11449
Other clones	IP17335
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT15878 HL03375 LD11292 RE53436 RE63829 SD03177 SD07705 SD14045
Other clones	1697 11548 21223 35220 45804 66733 71879 74857 102633 107927 145196 149886 174125 177219 214283.62 214285.60 214307.58 214351.64 214373.66 214405.83 214407.63 214443.70 562067 CK01.15B.A4 CK01.54C.F2 CK01.68D.B4 CK01.127D.F8 CK01.130D.B6 EK044253 EK055029 EK098640 EK135463 EK145228 EK162243 EK173344 EK195501 EK200541 EK206023 EK234174 EK235906 EK252853 EK282356 EK291849 EN13641 EP02531 EP08054 EP11011 EP13514 EP16102
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0260003 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42327 42332 248312
Antibody Information
	polyclonal (Fradkin et al., 2008)
Other Information
Discoverer
	Nichols-Skoog, 27th Nov. 1935.
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Dys det (Fradkin et al., 2009.1.16)
Source for database merge of	Source for merge of: det Dys (Christoforou et al., 2008) Source for merge of: Dys CG7240 (FlyBase Genome Annotators, 2006, FlyBase, 1996-)
Additional comments	Source for merge of Dys CG7240 was sequence comparison (date:001003). (FlyBase Genome Annotators, 2006, FlyBase, 1996-) Annotations CG17750, CG7240 merged as CG31175 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
Other Comments
	det is a non-essential gene in D.melanogaster. (Christoforou et al., 2008) The sole overt morphological defect associated with null det mutations is the variable loss of the posterior crossvein. (Christoforou et al., 2008) gbb and the Dp186 isoform of Dys have an additive effect on synaptic currents, acting through separate non-interacting pathways. (Fradkin et al., 2008) Absence of the large Dys isoforms in the post-synaptic muscle cell leads to elevated evoked neurotransmitter release from the presynaptic apparatus. (van der Plas et al., 2006) Short-term synaptic facilitation of evoked transmitter release is decreased in the mutants, suggesting that the absence of Dys results in increased probability of release. (van der Plas et al., 2006) One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders. (Inlow and Restifo, 2004) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Loss of vein mutations cause suppression of rhohs.PSt ectopic vein phenotype and enhancement of the rhove-1 loss of vein phenotype. (Sturtevant and Bier, 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001043256 NM_001043257 NM_001043258 NM_001043259 NM_001043260 NM_001043261 NM_001043262 NM_001043263 RefSeq (Proteins) • NP_001036721 NP_001036722 NP_001036723 NP_001036724 NP_001036725 NP_001036726 NP_001036727 NP_001036728 DDBJ / EMBL / GenBank • AAF55673 AAF55675 AAF55676 AAG17395 AAK15256 AAK15257 AAK15258 AAK18176 AAQ22489 AAX59985 ABI31176 ABI31177 ABI31178 ABI31179 ABI31180 AC008192 AF277386 AF297644 AF300294 AF300456 AF302236 AI531887 AY875639 BG636373 BI170096 BT010020 CAA68088 CZ470227 CZ470261 CZ473288 CZ473289 CZ476732 CZ478357 CZ478358 CZ481315 CZ482958 CZ483030 CZ483540 CZ488484 X99757 Entrez Gene - A searchable database of RefSeq genes. • 42327 UniProtKB/Swiss-Prot • Q0KI50 Q7YU29 Q9VDW3 Q9VDW6 UniProtKB/TrEMBL • Q7YU29
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, ZZ-type (IPR000433) WW/Rsp5/WWP (IPR001202) Actinin-type, actin-binding, conserved site (IPR001589) Calponin homology domain (IPR001715) Spectrin repeat (IPR002017) EF-hand-like domain (IPR011992) EF-hand domain, type 1 (IPR015153) EF-hand domain, type 2 (IPR015154) Spectrin/alpha-actinin (IPR018159)
Linkouts
	BioGRID - A database of protein and genetic interactions • 67322 DroID - A comprehensive database of gene and protein interactions. • FBgn0260003 DRSC - Results from RNAi screens. • FBgn0260003 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0260003 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0260003 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42327 42332 248312 InParanoid A subset of ortholog calls from InParanoid. • XP_001943041.1 Acyrthosiphon pisum (pea aphid) ENSBTAP00000012740 Bos taurus (bovine) CN29324 Caenorhabditis brenneri (small nematode) CE27129 Caenorhabditis elegans (worm) ENSCAFP00000000453 Canis familiaris (dog) JA11377 Caenorhabditis japonica (nematode) CPIJ013032 Culex pipens (mosquito) ENSCPOP00000000752 Cavia porcellus (guinea pig) RP39670 Caenorhabditis remanei (nematode) 160045 Capitella spl (polychaete worm) ENSECAP00000018392 Equus caballus (horse) ENSGACP00000020025 Gymnopilus aculeatus (mushroom) ENSGALP00000026200 Gallus gallus (chicken) ENSP00000354923 Homo sapiens (human) 169302 Lottia gigantea (owl limpet) ENSMODP00000021501 Monodelphis domestica (gray opossum) ENSMMUP00000025426 Macaca mulatta (rhesus monkey) ENSMUSP00000109633 Mus musculus (house mouse) ENSOANP00000017265 Ornithorynchus anatinus (platypus) ENSORLP00000025562 Oryzias latipes (japanese killifish) PHUM004359-PA Pediculus humanus (human body louse) PP26528 Pristionchus pacificus (nematode) ENSPPYP00000022629 Pongo pygmaeus (orangutan) ENSPTRP00000047461 Pan troglodytes (chimpanzee) ENSRNOP00000029969 Rattus norvegicus (norway rat) Smp_076500 Schistosoma mansoni (trematode parasite) NP_999661.1 Strongylocentrotus purpuratus (purple sea urchin) ENSTNIP00000015226 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000046695 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000048228 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /cytoskel/dystrophin1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42327 modMine - Data generated by the modENCODE project. • FBgn0260003 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV50088 LH19855 ISCW001113 FBgn0242670 FBgn0215824 FBgn0209830 FBgn0190797 FBgn0186841 FBgn0175131 JGI_V11_94977 FBgn0248946 FBgn0150260 FBgn0145831 FBgn0129756 FBgn0115490 FBgn0093575 CPIJ013032 BGIBMGA008637 ACYPI005709 GB11865 PB19849 PHUM253810
Synonyms & Secondary IDs ( 32 )
Reported As
Symbol Synonym	CG7240 (Goldstein and Gunawardena, 2000, Goldstein and Gunawardena, 2000) CG7243 (Dekkers et al., 2004, Goldstein and Gunawardena, 2000) CG7344 (Ma et al., 2006) CG17750   CG31175 (Huang et al., 2005, Metaxakis et al., 2005) CG34157 (FlyBase Genome Annotators, 2006, Keleman et al., 2009.8.5, Ni et al., 2008) det (Christoforou et al., 2008, Ray et al., 2007, Jaramillo et al., 2009, Pilgram et al., 2011) DLP (Neuman et al., 2005) DLP1 (Neuman, 2000.8.28, Pilgram et al., 2011) DLP2 (van der Plas et al., 2006, Neuman, 2000.8.21, Pilgram et al., 2011) DLP3 (Neuman, 2000.8.31, Pilgram et al., 2011) DLP186 (Neuman, 2000.8.27) DmDLP   dmDLP (Nudel et al., 2005, Neuman et al., 2001) dmDp186   DmDYS (Greener and Roberts, 2000) dmDys (Mosqueira et al., 2010) Dp117 (Pilgram et al., 2011) Dp186 (Fradkin et al., 2008, Pilgram et al., 2011) Dp205 (Neuman et al., 2005.1.4, Pilgram et al., 2011) Dys (Bogdanik et al., 2008, Shcherbata et al., 2007, Kucherenko et al., 2007, Schneider et al., 2006, Pantoja et al., 2008, van der Plas et al., 2007, Kucherenko et al., 2008, Shcherbata et al., 2007, Fradkin et al., 2009.1.16, Fradkin et al., 2008, Pilgram et al., 2011, Wasbrough et al., 2010) dys (Fradkin et al., 2008, Qian et al., 2008, Qian and Bodmer, 2009, Mirouse et al., 2009, Taghli-Lamallem et al., 2008, Mirouse et al., 2009) GI3046716 (Goldstein and Gunawardena, 2000) IDLP (Roberts and Bobrow, 1998)
Name Synonym	detached (Christoforou et al., 2008, Ray et al., 2007, Jaramillo et al., 2009, Pilgram et al., 2011) Dystrophin (Bogdanik et al., 2008, Burnette, 2005, Shcherbata et al., 2007, Kucherenko et al., 2007, Christoforou et al., 2008, Kucherenko et al., 2008, Shcherbata et al., 2007, Fradkin et al., 2009.1.16, Taghli-Lamallem et al., 2008, Roberts and Bobrow, 1998, Pilgram et al., 2011) dystrophin (Ray et al., 2007, Montana and Littleton, 2006, Pantoja et al., 2008, van der Plas et al., 2006, Yatsenko et al., 2007, van der Plas et al., 2007, Qian et al., 2008, Qian and Bodmer, 2009, Kohsaka et al., 2007) Dystrophin Dp186 (Fradkin et al., 2008) Dystrophin-like protein 1 (Neuman, 2000.8.28) Dystrophin-like protein 2 (van der Plas et al., 2006, Neuman, 2000.8.21) Dystrophin-like protein 3 (Neuman, 2000.8.31) Dystrophin-like protein 186 (Neuman, 2000.8.27)
Secondary FlyBase IDs
	FBan0007344 FBgn0000435 FBgn0024242 FBgn0038710 FBgn0038711 FBgn0038713 FBgn0051175
References ( 97 )
Generate a list of	All references relating to this gene ( 97 )
List References by type	Research paper  ( 35 ) Supplementary material  ( 10 ) Review  ( 7 ) Personal communication to FlyBase  ( 16 ) Abstract  ( 9 ) FlyBase analysis  ( 5 ) DNA/RNA sequence record  ( 6 ) Protein sequence record  ( 2 ) Computer file  ( 3 ) Book  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 3 )
	Kucherenko et al., 2011, Dev. Biol. 352(2): 228--242 Stress and muscular dystrophy: a genetic screen for dystroglycan and dystrophin interactors in Drosophila identifies cellular stress response components. [FBrf0214383] Pilgram et al., 2011, J. Neurosci. 31(2): 492--500 The RhoGAP crossveinless-c Interacts with Dystrophin and Is Required for Synaptic Homeostasis at the Drosophila Neuromuscular Junction. [FBrf0212767] Mosqueira et al., 2010, PLoS ONE 5(10): e13450 Chronic Hypoxia Impairs Muscle Function in the Drosophila Model of Duchenne's Muscular Dystrophy (DMD). [FBrf0212137] Show all research papers ...
Recent reviews ( 1 )
	Pilgram et al., 2010, Molec. Neurobiol. 41(1): 1--21 The roles of the dystrophin-associated glycoprotein complex at the synapse. [FBrf0212855] Show all reviews ...