Gene Dmel\drd

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Nose resistant-to-fluoxetine protein, N-terminal (IPR006621)

Acyltransferase 3 (IPR002656)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Crossreferences

Expression Data

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

embryonic/larval neuromuscular junction

ring gland

adult stage

interneuron

interneuron of optic lobe

corpus allatum

neurosecretory cell

adult stage | female

ovarian sheath

female accessory gland

adult stage | male

male accessory gland

in situ RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 8 -- 11

ventral neurectoderm

embryonic stage 15 -- 16

presumptive embryonic/larval central nervous system

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | female

organism

Comment:heads and bodies assayed separately

adult stage | male

organism

Comment:heads and bodies assayed separately

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 17 -- adult stage

organism

Comment:7-16 hr AEL not assayed

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

(The modENCODE Consortium, 2010, Graveley et al., 2011)

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression in all larval and adult organs/tissues ranges from low to undetected. Expression at high levels in the following post-embryonic organs or tissues: larval hindgut. Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, adult hindgut, larval trachea.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		3
central nervous system, larvae L3		1
central nervous system, pupae P8		1
head, virgin 1-day female		15
head, virgin 4-day female		5
head, virgin 20-day female		4
head, mated 1-day female		9
head, mated 4-day female		3
head, mated 20-day female		3
head, mated 1-day male		13
head, mated 4-day male		8
head, mated 20-day male		6
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		7
digestive system, 1-day adult		7
digestive system, 4-day adult		6
digestive system, 20-day adult		3
fat body, larvae L3 wandering		2
fat body, white prepupae		0
fat body, pupae P8		0
carcass, larvae L3 wandering		6
carcass, 1-day adult		5
carcass, 4-day adult		4
carcass, 20-day adult		3
ovary, virgin 4-day female		2
ovary, mated 4-day female		3
testis, mated 4-day male		2
accessory gland, mated 4-day male		1
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		3
central nervous system, larvae L3		1
central nervous system, pupae P8		1
head, virgin 1-day female		15
head, virgin 4-day female		5
head, virgin 20-day female		4
head, mated 1-day female		9
head, mated 4-day female		3
head, mated 20-day female		3
head, mated 1-day male		13
head, mated 4-day male		8
head, mated 20-day male		6
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		7
digestive system, 1-day adult		7
digestive system, 4-day adult		6
digestive system, 20-day adult		3
fat body, larvae L3 wandering		2
fat body, white prepupae		0
fat body, pupae P8		0
carcass, larvae L3 wandering		6
carcass, 1-day adult		5
carcass, 4-day adult		4
carcass, 20-day adult		3
ovary, virgin 4-day female		2
ovary, mated 4-day female		3
testis, mated 4-day male		2
accessory gland, mated 4-day male		1
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		3
central nervous system, larvae L3		1
central nervous system, pupae P8		1
head, virgin 1-day female		15
head, virgin 4-day female		5
head, virgin 20-day female		4
head, mated 1-day female		9
head, mated 4-day female		3
head, mated 20-day female		3
head, mated 1-day male		13
head, mated 4-day male		8
head, mated 20-day male		6
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		7
digestive system, 1-day adult		7
digestive system, 4-day adult		6
digestive system, 20-day adult		3
fat body, larvae L3 wandering		2
fat body, white prepupae		0
fat body, pupae P8		0
carcass, larvae L3 wandering		6
carcass, 1-day adult		5
carcass, 4-day adult		4
carcass, 20-day adult		3
ovary, virgin 4-day female		2
ovary, mated 4-day female		3
testis, mated 4-day male		2
accessory gland, mated 4-day male		1
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		3
central nervous system, larvae L3		1
central nervous system, pupae P8		1
head, virgin 1-day female		15
head, virgin 4-day female		5
head, virgin 20-day female		4
head, mated 1-day female		9
head, mated 4-day female		3
head, mated 20-day female		3
head, mated 1-day male		13
head, mated 4-day male		8
head, mated 20-day male		6
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		7
digestive system, 1-day adult		7
digestive system, 4-day adult		6
digestive system, 20-day adult		3
fat body, larvae L3 wandering		2
fat body, white prepupae		0
fat body, pupae P8		0
carcass, larvae L3 wandering		6
carcass, 1-day adult		5
carcass, 4-day adult		4
carcass, 20-day adult		3
ovary, virgin 4-day female		2
ovary, mated 4-day female		3
testis, mated 4-day male		2
accessory gland, mated 4-day male		1
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		3
central nervous system, larvae L3		1
central nervous system, pupae P8		1
head, virgin 1-day female		15
head, virgin 4-day female		5
head, virgin 20-day female		4
head, mated 1-day female		9
head, mated 4-day female		3
head, mated 20-day female		3
head, mated 1-day male		13
head, mated 4-day male		8
head, mated 20-day male		6
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		7
digestive system, 1-day adult		7
digestive system, 4-day adult		6
digestive system, 20-day adult		3
fat body, larvae L3 wandering		2
fat body, white prepupae		0
fat body, pupae P8		0
carcass, larvae L3 wandering		6
carcass, 1-day adult		5
carcass, 4-day adult		4
carcass, 20-day adult		3
ovary, virgin 4-day female		2
ovary, mated 4-day female		3
testis, mated 4-day male		2
accessory gland, mated 4-day male		1
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		3
central nervous system, larvae L3		1
central nervous system, pupae P8		1
head, virgin 1-day female		15
head, virgin 4-day female		5
head, virgin 20-day female		4
head, mated 1-day female		9
head, mated 4-day female		3
head, mated 20-day female		3
head, mated 1-day male		13
head, mated 4-day male		8
head, mated 20-day male		6
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		7
digestive system, 1-day adult		7
digestive system, 4-day adult		6
digestive system, 20-day adult		3
fat body, larvae L3 wandering		2
fat body, white prepupae		0
fat body, pupae P8		0
carcass, larvae L3 wandering		6
carcass, 1-day adult		5
carcass, 4-day adult		4
carcass, 20-day adult		3
ovary, virgin 4-day female		2
ovary, mated 4-day female		3
testis, mated 4-day male		2
accessory gland, mated 4-day male		1
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		3
central nervous system, larvae L3		1
central nervous system, pupae P8		1
head, virgin 1-day female		15
head, virgin 4-day female		5
head, virgin 20-day female		4
head, mated 1-day female		9
head, mated 4-day female		3
head, mated 20-day female		3
head, mated 1-day male		13
head, mated 4-day male		8
head, mated 20-day male		6
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		7
digestive system, 1-day adult		7
digestive system, 4-day adult		6
digestive system, 20-day adult		3
fat body, larvae L3 wandering		2
fat body, white prepupae		0
fat body, pupae P8		0
carcass, larvae L3 wandering		6
carcass, 1-day adult		5
carcass, 4-day adult		4
carcass, 20-day adult		3
ovary, virgin 4-day female		2
ovary, mated 4-day female		3
testis, mated 4-day male		2
accessory gland, mated 4-day male		1
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		3
central nervous system, larvae L3		1
central nervous system, pupae P8		1
head, virgin 1-day female		15
head, virgin 4-day female		5
head, virgin 20-day female		4
head, mated 1-day female		9
head, mated 4-day female		3
head, mated 20-day female		3
head, mated 1-day male		13
head, mated 4-day male		8
head, mated 20-day male		6
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		7
digestive system, 1-day adult		7
digestive system, 4-day adult		6
digestive system, 20-day adult		3
fat body, larvae L3 wandering		2
fat body, white prepupae		0
fat body, pupae P8		0
carcass, larvae L3 wandering		6
carcass, 1-day adult		5
carcass, 4-day adult		4
carcass, 20-day adult		3
ovary, virgin 4-day female		2
ovary, mated 4-day female		3
testis, mated 4-day male		2
accessory gland, mated 4-day male		1
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 12-18 embryonic stages.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		1
embryo 02-04hr		1
embryo 04-06hr		1
embryo 06-08hr		1
embryo 08-10hr		2
embryo 10-12hr		2
embryo 12-14hr		2
embryo 14-16hr		18
embryo 16-18hr		133
embryo 18-20hr		51
embryo 20-22hr		35
embryo 22-24hr		36
larva L1		20
larva L2		14
larva L3 12hr old		21
larva L3 puffstage 1-2		8
larva L3 puffstage 3-6		10
larva L3 puffstage 7-9		9
white prepupae new		3
white prepupae 12hr		11
white prepupae 24hr		6
pupae 2d postWPP		5
pupae 3d postWPP		19
pupae 4d postWPP		10
adult male 01day		17
adult male 05day		11
adult male 30day		8
adult female 01day		12
adult female 05day		12
adult female 30day		10
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		1
embryo 02-04hr		1
embryo 04-06hr		1
embryo 06-08hr		1
embryo 08-10hr		2
embryo 10-12hr		2
embryo 12-14hr		2
embryo 14-16hr		18
embryo 16-18hr		(133)
embryo 18-20hr		(51)
embryo 20-22hr		(35)
embryo 22-24hr		(36)
larva L1		20
larva L2		14
larva L3 12hr old		21
larva L3 puffstage 1-2		8
larva L3 puffstage 3-6		10
larva L3 puffstage 7-9		9
white prepupae new		3
white prepupae 12hr		11
white prepupae 24hr		6
pupae 2d postWPP		5
pupae 3d postWPP		19
pupae 4d postWPP		10
adult male 01day		17
adult male 05day		11
adult male 30day		8
adult female 01day		12
adult female 05day		12
adult female 30day		10
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		1
embryo 02-04hr		1
embryo 04-06hr		1
embryo 06-08hr		1
embryo 08-10hr		2
embryo 10-12hr		2
embryo 12-14hr		2
embryo 14-16hr		18
embryo 16-18hr		(133)
embryo 18-20hr		51
embryo 20-22hr		35
embryo 22-24hr		36
larva L1		20
larva L2		14
larva L3 12hr old		21
larva L3 puffstage 1-2		8
larva L3 puffstage 3-6		10
larva L3 puffstage 7-9		9
white prepupae new		3
white prepupae 12hr		11
white prepupae 24hr		6
pupae 2d postWPP		5
pupae 3d postWPP		19
pupae 4d postWPP		10
adult male 01day		17
adult male 05day		11
adult male 30day		8
adult female 01day		12
adult female 05day		12
adult female 30day		10
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		1
embryo 02-04hr		1
embryo 04-06hr		1
embryo 06-08hr		1
embryo 08-10hr		2
embryo 10-12hr		2
embryo 12-14hr		2
embryo 14-16hr		18
embryo 16-18hr		133
embryo 18-20hr		51
embryo 20-22hr		35
embryo 22-24hr		36
larva L1		20
larva L2		14
larva L3 12hr old		21
larva L3 puffstage 1-2		8
larva L3 puffstage 3-6		10
larva L3 puffstage 7-9		9
white prepupae new		3
white prepupae 12hr		11
white prepupae 24hr		6
pupae 2d postWPP		5
pupae 3d postWPP		19
pupae 4d postWPP		10
adult male 01day		17
adult male 05day		11
adult male 30day		8
adult female 01day		12
adult female 05day		12
adult female 30day		10
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		1
embryo 02-04hr		1
embryo 04-06hr		1
embryo 06-08hr		1
embryo 08-10hr		2
embryo 10-12hr		2
embryo 12-14hr		2
embryo 14-16hr		18
embryo 16-18hr		133
embryo 18-20hr		51
embryo 20-22hr		35
embryo 22-24hr		36
larva L1		20
larva L2		14
larva L3 12hr old		21
larva L3 puffstage 1-2		8
larva L3 puffstage 3-6		10
larva L3 puffstage 7-9		9
white prepupae new		3
white prepupae 12hr		11
white prepupae 24hr		6
pupae 2d postWPP		5
pupae 3d postWPP		19
pupae 4d postWPP		10
adult male 01day		17
adult male 05day		11
adult male 30day		8
adult female 01day		12
adult female 05day		12
adult female 30day		10
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		1
embryo 02-04hr		1
embryo 04-06hr		1
embryo 06-08hr		1
embryo 08-10hr		2
embryo 10-12hr		2
embryo 12-14hr		2
embryo 14-16hr		18
embryo 16-18hr		(133)
embryo 18-20hr		(51)
embryo 20-22hr		(35)
embryo 22-24hr		(36)
larva L1		20
larva L2		14
larva L3 12hr old		21
larva L3 puffstage 1-2		8
larva L3 puffstage 3-6		10
larva L3 puffstage 7-9		9
white prepupae new		3
white prepupae 12hr		11
white prepupae 24hr		6
pupae 2d postWPP		5
pupae 3d postWPP		19
pupae 4d postWPP		10
adult male 01day		17
adult male 05day		11
adult male 30day		8
adult female 01day		12
adult female 05day		12
adult female 30day		10
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		1
embryo 02-04hr		1
embryo 04-06hr		1
embryo 06-08hr		1
embryo 08-10hr		2
embryo 10-12hr		2
embryo 12-14hr		2
embryo 14-16hr		18
embryo 16-18hr		133
embryo 18-20hr		51
embryo 20-22hr		35
embryo 22-24hr		36
larva L1		20
larva L2		14
larva L3 12hr old		21
larva L3 puffstage 1-2		8
larva L3 puffstage 3-6		10
larva L3 puffstage 7-9		9
white prepupae new		3
white prepupae 12hr		11
white prepupae 24hr		6
pupae 2d postWPP		5
pupae 3d postWPP		19
pupae 4d postWPP		10
adult male 01day		17
adult male 05day		11
adult male 30day		8
adult female 01day		12
adult female 05day		12
adult female 30day		10
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		1
embryo 02-04hr		1
embryo 04-06hr		1
embryo 06-08hr		1
embryo 08-10hr		2
embryo 10-12hr		2
embryo 12-14hr		2
embryo 14-16hr		18
embryo 16-18hr		133
embryo 18-20hr		51
embryo 20-22hr		35
embryo 22-24hr		36
larva L1		20
larva L2		14
larva L3 12hr old		21
larva L3 puffstage 1-2		8
larva L3 puffstage 3-6		10
larva L3 puffstage 7-9		9
white prepupae new		3
white prepupae 12hr		11
white prepupae 24hr		6
pupae 2d postWPP		5
pupae 3d postWPP		19
pupae 4d postWPP		10
adult male 01day		17
adult male 05day		11
adult male 30day		8
adult female 01day		12
adult female 05day		12
adult female 30day		10
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		0
embryonic 1182-4H		0
embryonic GM2		0
embryonic Kc167		1
embryonic S1		0
embryonic S3		0
leg disc CME L1		0
wing disc CME-W2		0
wing disc ML-DmD8		0
wing disc ML-DmD9		1
wing disc ML-DmD16-c3		0
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		0
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		0
ovary fGS/OSS		0
ovary OSC		1
ovary OSS		1
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		0
embryonic 1182-4H		0
embryonic GM2		0
embryonic Kc167		1
embryonic S1		0
embryonic S3		0
leg disc CME L1		0
wing disc CME-W2		0
wing disc ML-DmD8		0
wing disc ML-DmD9		1
wing disc ML-DmD16-c3		0
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		0
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		0
ovary fGS/OSS		0
ovary OSC		1
ovary OSS		1
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		0
embryonic 1182-4H		0
embryonic GM2		0
embryonic Kc167		1
embryonic S1		0
embryonic S3		0
leg disc CME L1		0
wing disc CME-W2		0
wing disc ML-DmD8		0
wing disc ML-DmD9		1
wing disc ML-DmD16-c3		0
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		0
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		0
ovary fGS/OSS		0
ovary OSC		1
ovary OSS		1
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		0
embryonic 1182-4H		0
embryonic GM2		0
embryonic Kc167		1
embryonic S1		0
embryonic S3		0
leg disc CME L1		0
wing disc CME-W2		0
wing disc ML-DmD8		0
wing disc ML-DmD9		1
wing disc ML-DmD16-c3		0
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		0
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		0
ovary fGS/OSS		0
ovary OSC		1
ovary OSS		1
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		0
embryonic 1182-4H		0
embryonic GM2		0
embryonic Kc167		1
embryonic S1		0
embryonic S3		0
leg disc CME L1		0
wing disc CME-W2		0
wing disc ML-DmD8		0
wing disc ML-DmD9		1
wing disc ML-DmD16-c3		0
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		0
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		0
ovary fGS/OSS		0
ovary OSC		1
ovary OSS		1
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		0
embryonic 1182-4H		0
embryonic GM2		0
embryonic Kc167		1
embryonic S1		0
embryonic S3		0
leg disc CME L1		0
wing disc CME-W2		0
wing disc ML-DmD8		0
wing disc ML-DmD9		1
wing disc ML-DmD16-c3		0
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		0
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		0
ovary fGS/OSS		0
ovary OSC		1
ovary OSS		1
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		0
embryonic 1182-4H		0
embryonic GM2		0
embryonic Kc167		1
embryonic S1		0
embryonic S3		0
leg disc CME L1		0
wing disc CME-W2		0
wing disc ML-DmD8		0
wing disc ML-DmD9		1
wing disc ML-DmD16-c3		0
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		0
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		0
ovary fGS/OSS		0
ovary OSC		1
ovary OSS		1
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		0
embryonic 1182-4H		0
embryonic GM2		0
embryonic Kc167		1
embryonic S1		0
embryonic S3		0
leg disc CME L1		0
wing disc CME-W2		0
wing disc ML-DmD8		0
wing disc ML-DmD9		1
wing disc ML-DmD16-c3		0
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		0
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		0
ovary fGS/OSS		0
ovary OSC		1
ovary OSS		1
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		2
cold shock, 4-day adult		2
heat shock, 4-day adult		5
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		3
Cadmium 50 mM 48 hrs, 4-day adult		4
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		2
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		2
Zinc 4.5 mM 48 hrs, 4-day adult		4
Ethanol 2.5% 3 hrs, larvae L3		3
Ethanol 5% 3 hrs, larvae L3		5
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		2
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		4
Paraquat 10 mM 48 hrs, 4-day adult		6
Rotenone 2 μg 12 hrs, larvae L3		4
Rotenone 8 μg 12 hrs, larvae L3		4
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		2
cold shock, 4-day adult		2
heat shock, 4-day adult		5
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		3
Cadmium 50 mM 48 hrs, 4-day adult		4
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		2
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		2
Zinc 4.5 mM 48 hrs, 4-day adult		4
Ethanol 2.5% 3 hrs, larvae L3		3
Ethanol 5% 3 hrs, larvae L3		5
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		2
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		4
Paraquat 10 mM 48 hrs, 4-day adult		6
Rotenone 2 μg 12 hrs, larvae L3		4
Rotenone 8 μg 12 hrs, larvae L3		4
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		2
cold shock, 4-day adult		2
heat shock, 4-day adult		5
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		3
Cadmium 50 mM 48 hrs, 4-day adult		4
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		2
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		2
Zinc 4.5 mM 48 hrs, 4-day adult		4
Ethanol 2.5% 3 hrs, larvae L3		3
Ethanol 5% 3 hrs, larvae L3		5
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		2
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		4
Paraquat 10 mM 48 hrs, 4-day adult		6
Rotenone 2 μg 12 hrs, larvae L3		4
Rotenone 8 μg 12 hrs, larvae L3		4
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		2
cold shock, 4-day adult		2
heat shock, 4-day adult		5
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		3
Cadmium 50 mM 48 hrs, 4-day adult		4
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		2
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		2
Zinc 4.5 mM 48 hrs, 4-day adult		4
Ethanol 2.5% 3 hrs, larvae L3		3
Ethanol 5% 3 hrs, larvae L3		5
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		2
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		4
Paraquat 10 mM 48 hrs, 4-day adult		6
Rotenone 2 μg 12 hrs, larvae L3		4
Rotenone 8 μg 12 hrs, larvae L3		4
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		2
cold shock, 4-day adult		2
heat shock, 4-day adult		5
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		3
Cadmium 50 mM 48 hrs, 4-day adult		4
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		2
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		2
Zinc 4.5 mM 48 hrs, 4-day adult		4
Ethanol 2.5% 3 hrs, larvae L3		3
Ethanol 5% 3 hrs, larvae L3		5
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		2
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		4
Paraquat 10 mM 48 hrs, 4-day adult		6
Rotenone 2 μg 12 hrs, larvae L3		4
Rotenone 8 μg 12 hrs, larvae L3		4
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		2
cold shock, 4-day adult		2
heat shock, 4-day adult		5
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		3
Cadmium 50 mM 48 hrs, 4-day adult		4
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		2
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		2
Zinc 4.5 mM 48 hrs, 4-day adult		4
Ethanol 2.5% 3 hrs, larvae L3		3
Ethanol 5% 3 hrs, larvae L3		5
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		2
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		4
Paraquat 10 mM 48 hrs, 4-day adult		6
Rotenone 2 μg 12 hrs, larvae L3		4
Rotenone 8 μg 12 hrs, larvae L3		4
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		2
cold shock, 4-day adult		2
heat shock, 4-day adult		5
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		3
Cadmium 50 mM 48 hrs, 4-day adult		4
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		2
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		2
Zinc 4.5 mM 48 hrs, 4-day adult		4
Ethanol 2.5% 3 hrs, larvae L3		3
Ethanol 5% 3 hrs, larvae L3		5
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		2
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		4
Paraquat 10 mM 48 hrs, 4-day adult		6
Rotenone 2 μg 12 hrs, larvae L3		4
Rotenone 8 μg 12 hrs, larvae L3		4
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		2
cold shock, 4-day adult		2
heat shock, 4-day adult		5
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		3
Cadmium 50 mM 48 hrs, 4-day adult		4
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		2
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		2
Zinc 4.5 mM 48 hrs, 4-day adult		4
Ethanol 2.5% 3 hrs, larvae L3		3
Ethanol 5% 3 hrs, larvae L3		5
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		2
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		4
Paraquat 10 mM 48 hrs, 4-day adult		6
Rotenone 2 μg 12 hrs, larvae L3		4
Rotenone 8 μg 12 hrs, larvae L3		4
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

External Data & Images

behavior defective | adult stage

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0260006

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG32589-RA;CG5652-RA

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

lethal | adult stage

lethal | adult stage (with drd^CB6275-3)

drd^lwf

lethal | adult stage (with drd^lwf)

drd^CB6275-3

lethal | adult stage | recessive

drd¹

viable, with Scer\GAL4^pnr-MD237

drd^GD3367

Sterility

Allele

female sterile

female sterile (with drd¹)

drd^lwf

female sterile (with drd^lwf)

drd¹

female sterile | partially

drd²

fertile (with drd^CB6275-3)

drd^lwf

fertile (with drd^lwf)

drd^CB6275-3

Other Phenotypes

Allele

drd¹

feeding behavior defective

drd^lwf

hypoactive

drd²

short lived

drd^lwf

short lived (with drd¹)

drd^lwf

short lived (with drd^lwf)

drd¹

short lived | heat sensitive

drd^x3

short lived | male, with Dcr-2^Scer\UAS.cDa, Scer\GAL4^Act5C.PI

short lived | male | heat sensitive, with Dcr-2^Scer\UAS.cDa, Scer\GAL4^hs.PB

drd^GD15915

small body

small body (with drd¹)

drd^lwf

small body (with drd^lwf)

drd¹

visible

drd²

Phenotype manifest in

Allele

abdomen

drd²

adult brain

drd¹

crop

crop (with drd¹)

drd^lwf

crop (with drd^CB6275-3)

drd^lwf

crop (with drd^lwf)

egg chamber

drd¹

egg chamber (with drd¹)

drd^lwf

egg chamber (with drd^CB6275-3)

drd^lwf

egg chamber (with drd^lwf)

glial cell & adult brain

drd¹

optic lobe

drd¹

wing

drd²

Classical Alleles ( 14 )

For All Classical Alleles Show

Allele of drd	Mutagen	Stocks	Known lesion
drd¹	ethyl methanesulfonate	1	--
drd^f06365		1	--
drd^MB02377		1	--
drd^x1		1	Yes
drd²	ethyl methanesulfonate	0	--
drd^CB6275-3	P-element activity	0	Yes
drd^CPTI001223	piggyBac transposase	0	Yes
drd^G3	P-element activity	0	Yes
drd^GG01580		0	--
drd^lwf	ethyl methanesulfonate	0	Yes
drd^unspecified		0	--
drd^W3	P-element activity	0	Yes
drd^x3		0	--
drd^x4		0	Yes

Alleles Carried on Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Allele of drd	Mutagen	Stocks	Known lesion
drd^GD3367	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
drd^KK110343	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
drd^GD15915	in vitro construct - regulatory fusion in vitro construct - RNAi	0	Yes
drd^Scer\UAS.cSa	in vitro construct - regulatory fusion	0	Yes

Aneuploid Aberrations

Disrupted in

Df(1)Exel6249

(Ryder, 2004.4.26)

Df(1)RK4

(Buchanan and Benzer, 1993)

In(1)drd^x1

Duplicated in

Dp(1;3)DC294

(Popodi et al., 2010-, Venken et al., 2010)

Dp(1;Y)BSC231

(Cook et al., 2010)

Partially disrupted in

In(1)drd^x1

PBac{681.P.FSVS-1}drd^CPTI001223

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{KK110343}

P{UAS-drd.S}

characterization construct

P{GD15915}

Insertions

Type of insertions

Name

Expression data

miscellaneous insertions

P{unk}drd^CB6275-3

PBac{WH}drd^f06365

insertion of mobile activating element

P{Mae-UAS.6.11}drd^GG01580

insertion of enhancer trap binary system

Mi{ET1}drd^MB02377

Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )

Terms Based on Experimental Evidence ( 5 terms )

Molecular Function ( 0 terms)

Biological Process

CV term

chitin-based cuticle development

References

inferred from mutant phenotype

defecation

inferred from direct assay

digestion

inferred from direct assay

(Dzitoyeva et al., 2003, Blumenthal, 2008)

inferred from mutant phenotype

(Blumenthal, 2007)

digestive system process

inferred from mutant phenotype

(Peller et al., 2009)

oogenesis

inferred from mutant phenotype

Cellular Component ( 0 terms)

Terms Based on Predictions or Assertions ( 3 terms )

Molecular Function

CV term

transferase activity, transferring acyl groups other than amino-acyl groups

References

inferred from electronic annotation with InterPro:IPR002656

(FlyBase Curators et al., 2004-)

Biological Process

CV term

References

response to salt stress

non-traceable author statement

(Blumenthal, 2004)

Cellular Component

CV term

(Kretzschmar et al., 1993)

References

integral to membrane

inferred from sequence or structural similarity

Sequence Ontology: Class of Gene

gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

drd allele

Gene

References

External Data

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0260006

Orthologs

OrthoDB Orthologs (34) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG6KH3DF

Dipteran inclusive ortholog search

EOG6CJVR5

Insect inclusive ortholog search

EOG6BVQPM

Arthropod inclusive ortholog search

EOG6HQC08

Metazoa inclusive ortholog search

No orthologs identified

Orthologs in Drosophila Species (EOG6KH3DF)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA24043

Drosophila persimilis

Dper\GL15183

Drosophila willistoni

Dwil\GK16190

Drosophila virilis

Dvir\GJ15872

Drosophila mojavensis

Dmoj\GI21692

Drosophila grimshawi

Dgri\GH24644

Orthologs in non-Drosophila Dipterans (EOG6CJVR5)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL001466

Anopheles gambiae

Malaria mosquito

Agam\AGAP000629

Anopheles gambiae

Malaria mosquito

Agam\AGAP013491

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ010176

Orthologs in non-Dipteran Insects (EOG6BVQPM)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Apis mellifera

Western honey bee

Amel\Ame.30245

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG006912

Acromyrmex echinatior

Panamanian leafcutter ant

Aech\AECH15594

Atta cephalotes

Leafcutter ant

Acep\ACEP17812

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO14941

Harpegnathos saltator

Jerdons jumping ant

Hsal\HSAL22584

Linepithema humile

Argentine ant

Lhum\LH15118

Pogonomyrmex barbatus

Red harvester ant

Pbar\PB12462

Solenopsis invicta

Red fire ant

Sinv\SINV10747

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI006867

Bombyx mori

Silkmoth

Bmor\BGIBMGA001288

Pediculus humanus

Human body louse

Phum\PHUM216910

Pediculus humanus

Human body louse

Phum\PHUM206400

Tribolium castaneum

Red flour beetle

Tcas\TC014422

Orthologs in non-Insect Arthropods (EOG6HQC08)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Ixodes scapularis

Deer tick

Isca\ISCW004184

Ixodes scapularis

Deer tick

Isca\ISCW004368

Ixodes scapularis

Deer tick

Isca\ISCW011320

Ixodes scapularis

Deer tick

Isca\ISCW010550

Orthologs in non-Arthropod Metazoa (None identified)

No non-Arthropod Metazoa orthologies identified

Human Orthologs (0)

Gene

OMIM

HGNC

AAA Orthologs (0) based on analysis using Dmel annotation version 4.3

No orthologs identified

Stocks & Reagents

Stocks Listed in FlyBase ( 6 )

Bloomington

24901

drd¹/FM7c

27906

In(1)drd^x1, drd^x1/FM7c

24794

w¹¹¹⁸ Mi{ET1}drd^MB02377

v103032

v37404

w¹¹¹⁸; P{GD3367}v37404

Genomic Clones ( 1 )

BACR09F03

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 97 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

RE74651

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

DRSC - Results from RNAi screens.

•

FBgn0260006

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

318102

Antibody Information

Other Information

Discoverer

Etymology

The gene is named "beltless" based on the embryonic loss of function phenotype of missing denticle belts.

Identification

Relationship to Other Genes

Source for database identity of

Source for identity of: BcDNA:GM06434 CG5652

(Wang, 1999.11)

Source for identity of: beltless CG5652

(FlyBase Genome Annotators, 2005)

Source for database merge of

Source for merge of: CG32589 CG5652

Source for merge of: drd beltless

(FlyBase Genome Annotators, 2005)

Source for merge of: lwf CG33968

(Blumenthal, 2007)

Additional comments

Annotations CG32589 and CG5652 merged as CG33968 in release 4.3 of the genome annotation.

Not allelic to any of six adult-lethal (adl) genes mapping between v and f.

Other Comments

Mutant flies show a reduction in the transfer of ingested food from the crop to the midgut and an increased rate of crop contraction compared to controls.

(Peller et al., 2009)

Mutations in drd result in early adult lethality and neurodegeneration.

Mutant drd flies store significantly more food in their crops and defecate less than wild-type flies.

Identification: In an EMS screen for mutations that confer salt sensitivity in Drosophila.

(Blumenthal, 2004)

The lwf EMS line exhibits lethality within 5 days on food containing 0.4 M NaCl. The lwf EMS line has a normal body size and external morphology.

(Blumenthal, 2004)

Embryos in which beltless function has been reduced using RNA interference display a range of cuticular defects, ranging from partially differentiated cuticle to misdirected and partially formed denticle belts, and lack of denticle belts in abdominal segments A2-A4. The embryos fail to hatch.

The ovaries of adult females in which beltless function has been reduced using RNA interference are smaller than normal 72 hours after treatment with dsRNA, and the connections between the ovarioles are disorganised and loose. These females lay significantly fewer eggs than controls.

Approximately 65% of beltless RNAi embryos develop cuticular abnormalities, ranging from partially differentiated cuticle to misdirected and only partially-formed denticle belts.

(FlyBase Genome Annotators, 2002-2003)

New annotation (CG32589) in release 3 of the genome annotation.

In drd mutants the temporal pattern of expression of three different molecular biomarkers is accelerated.

(Rogina et al., 1997)

The expression pattern of drd suggests the gene function is required in specific glial cell types that play a role in the maintenance of brain integrity.

(Kretzschmar and Benzer, 1995)

Adult mutants exhibit severe behavioural defects and brain degeneration, these manifest a few days after emergence. Mosaic analysis reveals the drd gene product is non-cell autonomous. Defective glia in the adult brain may disrupt adult nervous system function, contributing to progressive brain degeneration and death. The wild type drd gene product may prevent brain degeneration by providing a necessary glial function.

(Buchanan and Benzer, 1993)

After normal development and normal behavior of young adults, flies begin to walk in uncoordinated manner and rapidly die (all dead by approximately ten days posteclosion); before death, there are gross holes in brain; mosaic experiment suggests primary defect is in brain. Second allele (drd²) causes similar effects with rapid death of population 9-11 days post-eclosion plus reduced female fertility.

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_001038756

RefSeq (Proteins)

•

NP_001033845

DDBJ / EMBL / GenBank

•

Entrez Gene - A searchable database of RefSeq genes.

•

318102

UniProtKB/TrEMBL

•

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Nose resistant-to-fluoxetine protein, N-terminal (IPR006621)

Acyltransferase 3 (IPR002656)

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0260006

DRSC - Results from RNAi screens.

•

FBgn0260006

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0260006

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG32589-RA;CG5652-RA

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0260006

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

318102

modMine - Data generated by the modENCODE project.

•

FBgn0260006

Synonyms & Secondary IDs ( 12 )

Reported As

Symbol Synonym

BcDNA:GM06434

beltless