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Gene Dmel\Su(var)3-3

General Information
Symbol	Dmel\Su(var)3-3	Species	D. melanogaster
Name	Suppressor of variegation 3-3	Annotation symbol	CG17149
Feature type	protein_coding_gene	FlyBase ID	FBgn0260397
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	dLsd1, lsd1, Suvar(3)3, Su-var(3)3
Genomic Location
Chromosome (arm)	3L	Recombination map	3-46.6
Cytogenetic map	77A3-77A3	Sequence location	3L:20,219,481..20,223,350 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Suppressor of variegation 3-3 is referred to in FlyBase by the symbol Dmel\Su(var)3-3 (CG17149, FBgn0260397). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: DNA binding; oxidoreductase activity; flavin adenine dinucleotide binding. There is experimental evidence that it is involved in the biological process: gene silencing; heterochromatin organization; chromatin organization; regulation of Notch signaling pathway; histone H3-K4 demethylation; imaginal disc-derived wing vein specification; oogenesis. 39 alleles are reported. The phenotypes of these alleles are annotated with: ovariole; egg; female germline cell; follicle cell; wing. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Amine oxidase; Histone lysine-specific demethylase; Homeodomain-like; SWIRM domain; Winged helix-turn-helix transcription repressor DNA-binding domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1634524_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Su(var)3-3. Gene sequence location is 3L:20219481..20223350.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Su(var)3-3 Homozygotes strongly semilethal in males; weakly so in females; homozygous females sterile; produce no eggs. Homozygous males have spread-wing phenotype and reduced fertility. Survival sensitive to the presence of the Y chromosome as well as to the presence of 0.1 M butyrate in the medium.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 77A3-77A3   Limits computationally determined from genome sequence between P{lacW}l(3)L1243L1243&P{lacW}Mi-2j3D4 and P{PZ}eRF100103
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	3-46.7 +/- 2.3 (Reuter et al., 1983) 3-46.6 +/- 0.2 (Reuter et al., 1986) 3-46.6
Left of (cM)	Ki (Reuter et al., 1986)
Right of (cM)	kni (Reuter et al., 1986)
Notes	Mapping on 3L based on its absence from induced C(3R)RM derivatives of Su(var)3-3-bearing chromosomes. (Reuter et al., 1986)
Gene Model & Products
Please see the GBrowse view of Dmel\Su(var)3-3 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.43 Gene model reviewed during 5.45
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Su(var)3-3-RA FBtr0074825  NM_140937   3681   890 Su(var)3-3-RB FBtr0074826  NM_168835   3615   890 Su(var)3-3-RC FBtr0332693  NM_001275171   3555   870
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Su(var)3-3-PA   FBpp0074594   98.4   890   7.88     NP_649194   AAF49052 Su(var)3-3-PB   FBpp0074595   98.4   890   7.88     NP_730497   AAF49051 Su(var)3-3-PC   FBpp0304939   95.9   870   7.33     NP_001262100   AGB94793
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Amine oxidase (IPR002937) SWIRM domain (IPR007526) Histone lysine-specific demethylase (IPR017366) Homeodomain-like (IPR009057) Winged helix-turn-helix DNA-binding domain (IPR011991)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA441358   AA540682   AA940855   AA942537   AE014296 AAF49051   AE014296 AAF49052   AE014296 AGB94793   AI512936   AW943760   AY094837 AAM11190   BF497130   BI167728   BI167759   BI214843   BI230263   BI231348   BI235054   BI236489   BI237856   BI366713   BI368638   BI373883   BI483942   CO265938   CO267283   CO268196   CO322888   CZ483143   EC059402   EC070903   EC084422   EC088632   EC200531   EC221838   EC229228   EC260187   GH833536   GH874152   GH875558   GH903294   GH920784
UniProtKB/Swiss-Prot	Q9VW97
UniProtKB/TrEMBL	B7Z0G7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Dorus et al., 2006)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleus inferred from direct assay (Eliazer et al., 2011) inferred from direct assay (assigned by UniProtKB) (Rudolph et al., 2007) transcriptional repressor complex inferred from physical interaction with CoRest (Dallman et al., 2004) inferred from physical interaction with Rpd3 (Dallman et al., 2004)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    200.825 Larval Midgut    37.7 Larval Hindgut    52.6 Larval Malpighian Tubules    56.2 Larval Fat Body    56.7 Larval Salivary Gland    72.4 Larval Trachea    72.95 Larval Carcass    62.6 Adult Head    52.5 Adult Eye    27.1 Adult Brain    107 Adult Thoracic-Abdominal Ganglion    85.5 Adult Crop    48.1 Adult Midgut    40.9 Adult Hindgut    32.8 Adult Malpighian Tubules    35.2 Adult Fat Body    29.7 Adult Salivary Gland    40.1 Adult Heart    20.925 Adult VirginFemale Spermatheca    45.4 Adult InseminatedFemale Spermatheca    52.5 Adult Ovary    293.6 Adult Testis    64 Adult Male Accessory Gland    87.5 Adult Carcass    34.1 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    200.825 Larval Midgut    37.7 Larval Hindgut    52.6 Larval Malpighian Tubules    56.2 Larval Fat Body    56.7 Larval Salivary Gland    72.4 Larval Trachea    72.95 Larval Carcass    62.6 Adult Head    52.5 Adult Eye    27.1 Adult Brain    107 Adult Thoracic-Abdominal Ganglion    85.5 Adult Crop    48.1 Adult Midgut    40.9 Adult Hindgut    32.8 Adult Malpighian Tubules    35.2 Adult Fat Body    29.7 Adult Salivary Gland    40.1 Adult Heart    20.925 Adult VirginFemale Spermatheca    45.4 Adult InseminatedFemale Spermatheca    52.5 Adult Ovary    293.6 Adult Testis    64 Adult Male Accessory Gland    87.5 Adult Carcass    34.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    200.825 Larval Midgut    37.7 Larval Hindgut    52.6 Larval Malpighian Tubules    56.2 Larval Fat Body    56.7 Larval Salivary Gland    72.4 Larval Trachea    72.95 Larval Carcass    62.6 Adult Head    52.5 Adult Eye    27.1 Adult Brain    107 Adult Thoracic-Abdominal Ganglion    85.5 Adult Crop    48.1 Adult Midgut    40.9 Adult Hindgut    32.8 Adult Malpighian Tubules    35.2 Adult Fat Body    29.7 Adult Salivary Gland    40.1 Adult Heart    20.925 Adult VirginFemale Spermatheca    45.4 Adult InseminatedFemale Spermatheca    52.5 Adult Ovary    293.6 Adult Testis    64 Adult Male Accessory Gland    87.5 Adult Carcass    34.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    200.825 Larval Midgut    37.7 Larval Hindgut    52.6 Larval Malpighian Tubules    56.2 Larval Fat Body    56.7 Larval Salivary Gland    72.4 Larval Trachea    72.95 Larval Carcass    62.6 Adult Head    52.5 Adult Eye    27.1 Adult Brain    107 Adult Thoracic-Abdominal Ganglion    85.5 Adult Crop    48.1 Adult Midgut    40.9 Adult Hindgut    32.8 Adult Malpighian Tubules    35.2 Adult Fat Body    29.7 Adult Salivary Gland    40.1 Adult Heart    20.925 Adult VirginFemale Spermatheca    45.4 Adult InseminatedFemale Spermatheca    52.5 Adult Ovary    293.6 Adult Testis    64 Adult Male Accessory Gland    87.5 Adult Carcass    34.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    200.825 Larval Midgut    37.7 Larval Hindgut    52.6 Larval Malpighian Tubules    56.2 Larval Fat Body    56.7 Larval Salivary Gland    72.4 Larval Trachea    72.95 Larval Carcass    62.6 Adult Head    52.5 Adult Eye    27.1 Adult Brain    107 Adult Thoracic-Abdominal Ganglion    85.5 Adult Crop    48.1 Adult Midgut    40.9 Adult Hindgut    32.8 Adult Malpighian Tubules    35.2 Adult Fat Body    29.7 Adult Salivary Gland    40.1 Adult Heart    20.925 Adult VirginFemale Spermatheca    45.4 Adult InseminatedFemale Spermatheca    52.5 Adult Ovary    293.6 Adult Testis    64 Adult Male Accessory Gland    87.5 Adult Carcass    34.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    200.825 Larval Midgut    37.7 Larval Hindgut    52.6 Larval Malpighian Tubules    56.2 Larval Fat Body    56.7 Larval Salivary Gland    72.4 Larval Trachea    72.95 Larval Carcass    62.6 Adult Head    52.5 Adult Eye    27.1 Adult Brain    107 Adult Thoracic-Abdominal Ganglion    85.5 Adult Crop    48.1 Adult Midgut    40.9 Adult Hindgut    32.8 Adult Malpighian Tubules    35.2 Adult Fat Body    29.7 Adult Salivary Gland    40.1 Adult Heart    20.925 Adult VirginFemale Spermatheca    45.4 Adult InseminatedFemale Spermatheca    52.5 Adult Ovary    293.6 Adult Testis    64 Adult Male Accessory Gland    87.5 Adult Carcass    34.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    200.825 Larval Midgut    37.7 Larval Hindgut    52.6 Larval Malpighian Tubules    56.2 Larval Fat Body    56.7 Larval Salivary Gland    72.4 Larval Trachea    72.95 Larval Carcass    62.6 Adult Head    52.5 Adult Eye    27.1 Adult Brain    107 Adult Thoracic-Abdominal Ganglion    85.5 Adult Crop    48.1 Adult Midgut    40.9 Adult Hindgut    32.8 Adult Malpighian Tubules    35.2 Adult Fat Body    29.7 Adult Salivary Gland    40.1 Adult Heart    20.925 Adult VirginFemale Spermatheca    45.4 Adult InseminatedFemale Spermatheca    52.5 Adult Ovary    293.6 Adult Testis    64 Adult Male Accessory Gland    87.5 Adult Carcass    34.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    200.825 Larval Midgut    37.7 Larval Hindgut    52.6 Larval Malpighian Tubules    56.2 Larval Fat Body    56.7 Larval Salivary Gland    72.4 Larval Trachea    72.95 Larval Carcass    62.6 Adult Head    52.5 Adult Eye    27.1 Adult Brain    107 Adult Thoracic-Abdominal Ganglion    85.5 Adult Crop    48.1 Adult Midgut    40.9 Adult Hindgut    32.8 Adult Malpighian Tubules    35.2 Adult Fat Body    29.7 Adult Salivary Gland    40.1 Adult Heart    20.925 Adult VirginFemale Spermatheca    45.4 Adult InseminatedFemale Spermatheca    52.5 Adult Ovary    293.6 Adult Testis    64 Adult Male Accessory Gland    87.5 Adult Carcass    34.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    52.5   NA  Eye    27.1   NA  Brain    107   200.825  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    85.5   NA  Crop    48.1   37.7  Midgut    40.9   52.6  Hindgut    32.8   56.2  Malpighian Tubules    35.2   56.7  Fat Body    29.7   72.4  Salivary Gland    40.1   NA  Heart    20.925   72.95  Trachea    NA   NA  VirginFemale Spermatheca    45.4   NA  InseminatedFemale Spermatheca    52.5   NA  Ovary    293.6   NA  Testis    64   NA  Male Accessory Gland    87.5   62.6  Carcass    34.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    15 central nervous system, pupae P8    11 head, virgin 1-day female    4 head, virgin 4-day female    3 head, virgin 20-day female    3 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    5 head, mated 4-day male    5 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    4 carcass, larvae L3 wandering    8 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    39 ovary, mated 4-day female    33 testis, mated 4-day male    5 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    15 central nervous system, pupae P8    11 head, virgin 1-day female    4 head, virgin 4-day female    3 head, virgin 20-day female    3 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    5 head, mated 4-day male    5 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    4 carcass, larvae L3 wandering    8 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female  (39) ovary, mated 4-day female  (33) testis, mated 4-day male    5 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    15 central nervous system, pupae P8    11 head, virgin 1-day female    4 head, virgin 4-day female    3 head, virgin 20-day female    3 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    5 head, mated 4-day male    5 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    4 carcass, larvae L3 wandering    8 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    39 ovary, mated 4-day female    33 testis, mated 4-day male    5 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    15 central nervous system, pupae P8    11 head, virgin 1-day female    4 head, virgin 4-day female    3 head, virgin 20-day female    3 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    5 head, mated 4-day male    5 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    4 carcass, larvae L3 wandering    8 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    39 ovary, mated 4-day female    33 testis, mated 4-day male    5 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    15 central nervous system, pupae P8    11 head, virgin 1-day female    4 head, virgin 4-day female    3 head, virgin 20-day female    3 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    5 head, mated 4-day male    5 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    4 carcass, larvae L3 wandering    8 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    39 ovary, mated 4-day female    33 testis, mated 4-day male    5 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    15 central nervous system, pupae P8    11 head, virgin 1-day female    4 head, virgin 4-day female    3 head, virgin 20-day female    3 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    5 head, mated 4-day male    5 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    4 carcass, larvae L3 wandering    8 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female  (39) ovary, mated 4-day female  (33) testis, mated 4-day male    5 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    15 central nervous system, pupae P8    11 head, virgin 1-day female    4 head, virgin 4-day female    3 head, virgin 20-day female    3 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    5 head, mated 4-day male    5 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    4 carcass, larvae L3 wandering    8 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    39 ovary, mated 4-day female    33 testis, mated 4-day male    5 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    15 central nervous system, pupae P8    11 head, virgin 1-day female    4 head, virgin 4-day female    3 head, virgin 20-day female    3 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    5 head, mated 4-day male    5 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    4 carcass, larvae L3 wandering    8 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    39 ovary, mated 4-day female    33 testis, mated 4-day male    5 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    38 embryo 04-06hr    20 embryo 06-08hr    21 embryo 08-10hr    21 embryo 10-12hr    14 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    11 embryo 18-20hr    5 embryo 20-22hr    16 embryo 22-24hr    13 larva L1    5 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    7 white prepupae 12hr    7 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    3 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    4 adult male 30day    4 adult female 01day    8 adult female 05day    17 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (36) embryo 02-04hr  (38) embryo 04-06hr    20 embryo 06-08hr    21 embryo 08-10hr    21 embryo 10-12hr    14 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    11 embryo 18-20hr    5 embryo 20-22hr    16 embryo 22-24hr    13 larva L1    5 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    7 white prepupae 12hr    7 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    3 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    4 adult male 30day    4 adult female 01day    8 adult female 05day    17 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    38 embryo 04-06hr    20 embryo 06-08hr    21 embryo 08-10hr    21 embryo 10-12hr    14 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    11 embryo 18-20hr    5 embryo 20-22hr    16 embryo 22-24hr    13 larva L1    5 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    7 white prepupae 12hr    7 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    3 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    4 adult male 30day    4 adult female 01day    8 adult female 05day    17 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    38 embryo 04-06hr    20 embryo 06-08hr    21 embryo 08-10hr    21 embryo 10-12hr    14 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    11 embryo 18-20hr    5 embryo 20-22hr    16 embryo 22-24hr    13 larva L1    5 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    7 white prepupae 12hr    7 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    3 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    4 adult male 30day    4 adult female 01day    8 adult female 05day    17 adult female 30day    18 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    38 embryo 04-06hr    20 embryo 06-08hr    21 embryo 08-10hr    21 embryo 10-12hr    14 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    11 embryo 18-20hr    5 embryo 20-22hr    16 embryo 22-24hr    13 larva L1    5 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    7 white prepupae 12hr    7 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    3 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    4 adult male 30day    4 adult female 01day    8 adult female 05day    17 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (36) embryo 02-04hr  (38) embryo 04-06hr    20 embryo 06-08hr    21 embryo 08-10hr    21 embryo 10-12hr    14 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    11 embryo 18-20hr    5 embryo 20-22hr    16 embryo 22-24hr    13 larva L1    5 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    7 white prepupae 12hr    7 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    3 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    4 adult male 30day    4 adult female 01day    8 adult female 05day    17 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    38 embryo 04-06hr    20 embryo 06-08hr    21 embryo 08-10hr    21 embryo 10-12hr    14 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    11 embryo 18-20hr    5 embryo 20-22hr    16 embryo 22-24hr    13 larva L1    5 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    7 white prepupae 12hr    7 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    3 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    4 adult male 30day    4 adult female 01day    8 adult female 05day    17 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    38 embryo 04-06hr    20 embryo 06-08hr    21 embryo 08-10hr    21 embryo 10-12hr    14 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    11 embryo 18-20hr    5 embryo 20-22hr    16 embryo 22-24hr    13 larva L1    5 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    7 white prepupae 12hr    7 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    3 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    4 adult male 30day    4 adult female 01day    8 adult female 05day    17 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    16 embryonic 1182-4H    16 embryonic GM2    12 embryonic Kc167    11 embryonic S1    11 embryonic S3    23 leg disc CME L1    20 wing disc CME-W2    10 wing disc ML-DmD8    12 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    10 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    9 ovary fGS/OSS    17 ovary OSC    17 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    16 embryonic 1182-4H    16 embryonic GM2    12 embryonic Kc167    11 embryonic S1    11 embryonic S3    23 leg disc CME L1    20 wing disc CME-W2    10 wing disc ML-DmD8    12 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    10 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    9 ovary fGS/OSS    17 ovary OSC    17 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    16 embryonic 1182-4H    16 embryonic GM2    12 embryonic Kc167    11 embryonic S1    11 embryonic S3    23 leg disc CME L1    20 wing disc CME-W2    10 wing disc ML-DmD8    12 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    10 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    9 ovary fGS/OSS    17 ovary OSC    17 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    16 embryonic 1182-4H    16 embryonic GM2    12 embryonic Kc167    11 embryonic S1    11 embryonic S3    23 leg disc CME L1    20 wing disc CME-W2    10 wing disc ML-DmD8    12 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    10 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    9 ovary fGS/OSS    17 ovary OSC    17 ovary OSS    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    16 embryonic 1182-4H    16 embryonic GM2    12 embryonic Kc167    11 embryonic S1    11 embryonic S3    23 leg disc CME L1    20 wing disc CME-W2    10 wing disc ML-DmD8    12 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    10 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    9 ovary fGS/OSS    17 ovary OSC    17 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    16 embryonic 1182-4H    16 embryonic GM2    12 embryonic Kc167    11 embryonic S1    11 embryonic S3    23 leg disc CME L1    20 wing disc CME-W2    10 wing disc ML-DmD8    12 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    10 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    9 ovary fGS/OSS    17 ovary OSC    17 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    16 embryonic 1182-4H    16 embryonic GM2    12 embryonic Kc167    11 embryonic S1    11 embryonic S3    23 leg disc CME L1    20 wing disc CME-W2    10 wing disc ML-DmD8    12 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    10 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    9 ovary fGS/OSS    17 ovary OSC    17 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    16 embryonic 1182-4H    16 embryonic GM2    12 embryonic Kc167    11 embryonic S1    11 embryonic S3    23 leg disc CME L1    20 wing disc CME-W2    10 wing disc ML-DmD8    12 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    10 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    9 ovary fGS/OSS    17 ovary OSC    17 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_05
External Data & Images
Linkouts	BDGP expression data • LD45081 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0260397
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | recessive Su(var)3-31 lethal | male | recessive Su(var)3-3ΔN lethal | partially | recessive Su(var)3-31 Su(var)3-32 Su(var)3-33 Su(var)3-34 Su(var)3-35 Su(var)3-36 Su(var)3-37 Su(var)3-38 Su(var)3-39 Su(var)3-310 Su(var)3-311 Su(var)3-312 Su(var)3-313 Su(var)3-314 Su(var)3-315 Su(var)3-316 Su(var)3-317 Su(var)3-318 Su(var)3-319 Su(var)3-320 Su(var)3-321 Su(var)3-322 Su(var)3-323 Su(var)3-324 Su(var)3-325 partially lethal - majority die | male | recessive Su(var)3-3ΔN partially lethal - majority die | recessive Su(var)3-3ΔN viable, with Scer\GAL4pnr-MD237 Su(var)3-3GD9296 Sterility Allele female sterile, with Scer\GAL4C587, Su(var)3-3Scer\UAS.cDa Su(var)3-3ΔN female sterile, with Scer\GAL4C587, Su(var)3-3ΔN Su(var)3-3Scer\UAS.cDa female sterile | recessive Su(var)3-31 Su(var)3-32 Su(var)3-33 Su(var)3-34 Su(var)3-35 Su(var)3-36 Su(var)3-37 Su(var)3-38 Su(var)3-39 Su(var)3-310 Su(var)3-311 Su(var)3-312 Su(var)3-313 Su(var)3-314 Su(var)3-315 Su(var)3-316 Su(var)3-317 Su(var)3-318 Su(var)3-319 Su(var)3-320 Su(var)3-321 Su(var)3-322 Su(var)3-323 Su(var)3-324 Su(var)3-325 Su(var)3-3unspecified Su(var)3-3ΔN male sterile | partially | recessive Su(var)3-31 Su(var)3-32 Su(var)3-33 Su(var)3-34 Su(var)3-35 Su(var)3-36 Su(var)3-37 Su(var)3-38 Su(var)3-39 Su(var)3-310 Su(var)3-311 Su(var)3-312 Su(var)3-313 Su(var)3-314 Su(var)3-315 Su(var)3-316 Su(var)3-317 Su(var)3-318 Su(var)3-319 Su(var)3-320 Su(var)3-321 Su(var)3-322 Su(var)3-323 Su(var)3-324 Su(var)3-325 male sterile | recessive Su(var)3-3ΔN Other Phenotypes Allele flightless | recessive Su(var)3-3ΔN suppressor of variegation | dominant Su(var)3-3f00678 Su(var)3-3ΔN suppressor of variegation | dominant, with In(1)wm4h Su(var)3-31 Su(var)3-32 Su(var)3-33 Su(var)3-34 Su(var)3-35 Su(var)3-36 Su(var)3-37 Su(var)3-38 Su(var)3-39 Su(var)3-310 Su(var)3-311 Su(var)3-312 Su(var)3-313 Su(var)3-314 Su(var)3-315 Su(var)3-316 Su(var)3-317 Su(var)3-318 Su(var)3-319 Su(var)3-320 Su(var)3-321 Su(var)3-322 Su(var)3-323 Su(var)3-324 Su(var)3-325 Su(var)3-326 Su(var)3-3unspecified visible Su(var)3-3ΔN visible, with Scer\GAL469B Su(var)3-3VDRC.cUa visible, with Scer\GAL4bs.PU Su(var)3-3VDRC.cUa visible | male | recessive Su(var)3-31 Su(var)3-32 Su(var)3-33 Su(var)3-34 Su(var)3-35 Su(var)3-36 Su(var)3-37 Su(var)3-38 Su(var)3-39 Su(var)3-310 Su(var)3-311 Su(var)3-312 Su(var)3-313 Su(var)3-314 Su(var)3-315 Su(var)3-316 Su(var)3-317 Su(var)3-318 Su(var)3-319 Su(var)3-320 Su(var)3-321 Su(var)3-322 Su(var)3-323 Su(var)3-324 Su(var)3-325 visible | recessive Su(var)3-3ΔN Phenotype manifest in Allele anterior crossvein | ectopic, with Scer\GAL4bs.PU Su(var)3-3VDRC.cUa egg, with Scer\GAL4C587, Su(var)3-3Scer\UAS.cDa Su(var)3-3ΔN egg, with Scer\GAL4C587, Su(var)3-3ΔN Su(var)3-3Scer\UAS.cDa female germline cell Su(var)3-3ΔN female germline stem cell | supernumerary Su(var)3-3ΔN female germline stem cell | supernumerary, with Scer\GAL4C587 Su(var)3-3NIG.17149R follicle cell Su(var)3-3ΔN ovariole Su(var)3-3ΔN wing Su(var)3-31 Su(var)3-310 Su(var)3-311 Su(var)3-312 Su(var)3-3ΔN Su(var)3-313 Su(var)3-314 Su(var)3-315 Su(var)3-316 Su(var)3-317 Su(var)3-318 Su(var)3-319 Su(var)3-32 Su(var)3-320 Su(var)3-321 Su(var)3-322 Su(var)3-323 Su(var)3-324 Su(var)3-325 Su(var)3-33 Su(var)3-34 Su(var)3-35 Su(var)3-36 Su(var)3-37 Su(var)3-38 Su(var)3-39 wing vein | ectopic Su(var)3-3ΔN wing vein | ectopic, with Scer\GAL469B Su(var)3-3VDRC.cUa wing vein | ectopic, with Scer\GAL4bs.PU Su(var)3-3VDRC.cUa
Classical Alleles ( 30 )
For All Classical Alleles Show
Allele of Su(var)3-3 Class Mutagen Stocks Known lesion Su(var)3-3f00678 piggyBac transposase 1 -- Su(var)3-310 ethyl methanesulfonate 0 -- Su(var)3-311 ethyl methanesulfonate 0 -- Su(var)3-312 ethyl methanesulfonate 0 -- Su(var)3-313 X ray 0 -- Su(var)3-314 ethyl methanesulfonate 0 -- Su(var)3-315 ethyl methanesulfonate 0 -- Su(var)3-316 ethyl methanesulfonate 0 -- Su(var)3-317 ethyl methanesulfonate 0 -- Su(var)3-318 X ray 0 -- Su(var)3-319 X ray 0 -- Su(var)3-31 ethyl methanesulfonate 0 -- Su(var)3-320 ethyl methanesulfonate 0 -- Su(var)3-321 ethyl methanesulfonate 0 -- Su(var)3-322 ethyl methanesulfonate 0 -- Su(var)3-323 ethyl methanesulfonate 0 -- Su(var)3-324 ethyl methanesulfonate 0 -- Su(var)3-325 ethyl methanesulfonate 0 -- Su(var)3-326 PM hybrid dysgenesis 0 -- Su(var)3-32 ethyl methanesulfonate 0 -- Su(var)3-33 ethyl methanesulfonate 0 -- Su(var)3-34 ethyl methanesulfonate 0 -- Su(var)3-35 ethyl methanesulfonate 0 -- Su(var)3-36 ethyl methanesulfonate 0 -- Su(var)3-37 ethyl methanesulfonate 0 -- Su(var)3-38 ethyl methanesulfonate 0 -- Su(var)3-39 ethyl methanesulfonate 0 Yes Su(var)3-3EY20557 P-element activity 0 -- Su(var)3-3unspecified 0 -- Su(var)3-3ΔN FLPase 0 Yes
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Su(var)3-3 Class Mutagen Stocks Known lesion Su(var)3-3GD9296 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Su(var)3-3GL01006 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Su(var)3-3HMS00608 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Su(var)3-3HMS00638 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Su(var)3-3KK102965 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Su(var)3-3NIG.17149R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Su(var)3-3Scer\UAS.cDa in vitro construct - regulatory fusion 0 Yes Su(var)3-3T:Hsap\MYC in vitro construct - coding region fusion 0 Yes Su(var)3-3VDRC.cUa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)ED4858 (Di Stefano et al., 2007)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK102965} NA P{TRiP.GL01006} NA P{TRiP.HMS00608} NA P{TRiP.HMS00638} NA P{UAS-Lsd1.D} NA characterization construct P{NIG.17149R} NA P{VDRC.Su(var)3-3.U} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{}Su(var)3-326 NA P{SUPor-P}KG00346 NA PBac{WH}Su(var)3-3f00678 NA insertion of mobile activating element P{EP}MESK3EP3728 NA P{EPg}HP35938 NA P{EPgy2}Su(var)3-3EY20557 NA insertion of enhancer trap binary system Mi{ET1}CG17147MB11340 No
Gene Ontology: Function, Process & Cellular Component ( 14 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
chromatin organization inferred from mutant phenotype (Di Stefano et al., 2007) gene silencing inferred from mutant phenotype (assigned by UniProtKB) (Rudolph et al., 2007) heterochromatin organization inferred from mutant phenotype (Di Stefano et al., 2011) histone H3-K4 demethylation inferred from mutant phenotype (Di Stefano et al., 2011, Di Stefano et al., 2007) inferred from mutant phenotype (assigned by UniProtKB) (Rudolph et al., 2007) imaginal disc-derived wing vein specification inferred from mutant phenotype (Di Stefano et al., 2011, Curtis et al., 2011) oogenesis inferred from mutant phenotype (Di Stefano et al., 2011, Di Stefano et al., 2007) regulation of Notch signaling pathway inferred from mutant phenotype (Di Stefano et al., 2011)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Eliazer et al., 2011) inferred from direct assay (assigned by UniProtKB) (Rudolph et al., 2007) transcriptional repressor complex inferred from physical interaction with CoRest (Dallman et al., 2004) inferred from physical interaction with Rpd3 (Dallman et al., 2004)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
DNA binding inferred from electronic annotation with InterPro:IPR009057 (FlyBase Curators et al., 2004-) flavin adenine dinucleotide binding inferred from electronic annotation with InterPro:IPR017366 (FlyBase Curators et al., 2004-) oxidoreductase activity inferred from electronic annotation with InterPro:IPR002937 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
oxidation-reduction process inferred from electronic annotation with InterPro:IPR002937 (FlyBase Curators et al., 2004-) regulation of transcription, DNA-dependent inferred from electronic annotation with InterPro:IPR017366 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Su(var)3-3 - B52 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Su(var)3-3 - CG10077 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Su(var)3-3 - CG10306 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Su(var)3-3 - CG3817 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Su(var)3-3 - CG5642 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Su(var)3-3 - CG9769 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Su(var)3-3 - CoRest anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Su(var)3-3 - Gp210 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Su(var)3-3 - Int6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Su(var)3-3 - NHP2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Su(var)3-3 - Psi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Su(var)3-3 - RpL35A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Su(var)3-3 - Rpd3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Su(var)3-3 - Rsf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Su(var)3-3 - SdhB anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Su(var)3-3 - dod anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Su(var)3-3 - eIF3-S8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Su(var)3-3 - mRpS24 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Su(var)3-3 - mRpS33 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Su(var)3-3 allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0260397 DroID - A comprehensive database of gene and protein interactions. • FBgn0260397 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40217
Orthologs
OrthoDB Orthologs (36) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG62FT2Z Dipteran inclusive ortholog search EOG6K0QWF Insect inclusive ortholog search EOG6B2RSG Arthropod inclusive ortholog search EOG6905R9 Metazoa inclusive ortholog search EOG68M44S
Orthologs in Drosophila Species (EOG62FT2Z)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Su(var)3-3     Drosophila simulans   Dsim\GD14861 Y   Drosophila sechellia   Dsec\GM22263 Y   Drosophila erecta   Dere\GG16089 Y   Drosophila yakuba   Dyak\GE19651 Y   Drosophila ananassae   Dana\GF25315 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA14350 Y   Drosophila persimilis   Dper\GL25121 Y   Drosophila willistoni   Dwil\GK16943 Y   Drosophila virilis   Dvir\GJ11550 Y   Drosophila mojavensis   Dmoj\GI11530 Y   Drosophila grimshawi   Dgri\GH16339 Y
Orthologs in non-Drosophila Dipterans (EOG6K0QWF)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL011415   Anopheles gambiae Malaria mosquito  Agam\AGAP011661   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002197
Orthologs in non-Dipteran Insects (EOG6B2RSG)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB48386   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG023096   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH10888   Atta cephalotes Leafcutter ant  Acep\ACEP13436   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18255   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13392   Linepithema humile Argentine ant  Lhum\LH19739   Pogonomyrmex barbatus Red harvester ant  Pbar\PB12037   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009334   Bombyx mori Silkmoth  Bmor\BGIBMGA011022   Pediculus humanus Human body louse  Phum\PHUM106950
Orthologs in non-Insect Arthropods (EOG6905R9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\CRTAP   Ixodes scapularis Deer tick  Isca\ISCW019383
Orthologs in non-Arthropod Metazoa (EOG68M44S)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\spr-5   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010520gn   Danio rerio Zebrafish  Drer\kdm1a   Xenopus tropicalis Western clawed frog  Xtro\kdm1a   Gallus gallus Domestic chicken  Ggal\KDM1A   Mus musculus House mouse  Mmus\Kdm1a   Rattus norvegicus Norway rat  Rnor\Kdm1a   Homo sapiens Human  Hsap\KDM1A
Human Orthologs (1)
Gene OMIM HGNC Hsap\KDM1A
AAA Orthologs (22) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD14860 Drosophila simulans Dsim\GD14861 Drosophila sechellia Dsec\GM22261 Drosophila sechellia Dsec\GM22263 Drosophila erecta Dere\GG16088 Drosophila erecta Dere\GG16089 Drosophila yakuba Dyak\GE19650 Drosophila yakuba Dyak\GE19651 Drosophila ananassae Dana\GF25314 Drosophila ananassae Dana\GF25315 Drosophila pseudoobscura pseudoobscura Dpse\GA14350 Drosophila pseudoobscura pseudoobscura Dpse\GA23689 Drosophila persimilis Dper\GL25120 Drosophila persimilis Dper\GL25121 Drosophila willistoni Dwil\GK16942 Drosophila willistoni Dwil\GK16943 Drosophila virilis Dvir\GJ11548 Drosophila virilis Dvir\GJ11550 Drosophila mojavensis Dmoj\GI11529 Drosophila mojavensis Dmoj\GI11530 Drosophila grimshawi Dgri\GH16338 Drosophila grimshawi Dgri\GH16339
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	32853 y1 sc* v1; P{TRiP.HMS00638}attP2 36867 y1 sc* v1; P{TRiP.GL01006}attP40 33726 y1 sc* v1; P{TRiP.HMS00608}attP2/TM3, Sb1
Harvard	- PBac{WH}Su(var)3-3f00678
VDRC	v106147 P{KK102965}VIE-260B v25218 w1118; P{GD9296}v25218
Genomic Clones ( 2 )
	BACR16G09 BACR31C03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 35 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD45081
Other clones	DPiM_LD45081
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT11222 LD16261 LD20452 LD23130 LD26810 RE08178 RE08216 RE08940 RE20977 RE21405 RE30852 RE32548 RE34171 RE52309 RE54644 RE61314 RE66912
Other clones	34263 34558 61949 122810 214247.55 CK01.21B.E1 CK01.107C.C10 EK090541 EK144514 EK149331 EK189137 RP003075939 RP003304435 RP003322111 RP003333509 RP003425171
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0260397 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40217
Antibody Information
	polyclonal (Eliazer et al., 2011)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Hdm CG17149 (Singh, 2007.3.5)
Source for database merge of	Source for merge of: Su(var)3-3 Hdm (Rudolph et al., 2007)
Additional comments	The "Su(var)3-3" gene was previously mistakenly merged with the CG17147 gene in FlyBase. This error has been corrected and CG17147 has been split out into a separate gene from Su(var)3-3. The "Su(var)3-3" gene actually corresponds to the "CG17149" annotation. (FlyBase, 1996-)
Other Comments
	lid and Su(var)3-3 have opposing functions in the establishment of euchromatin and heterochromatin boundaries; Su(var)3-3 promotes heterochromatin formation, while lid promotes euchromatin formation. (Di Stefano et al., 2011) Su(var)3-3 and Wow represent different complementation groups based on their effects on w mutations and fertility/viability. (Birchler et al., 1994) No additive effect of mutant alleles with mod alleles on suppression of position effect variegation at In(1)wm4. (Garzino et al., 1992) Suppression of In(1)wm4 position effect variegation by Su(var)3-3 was reversed by a supernumerary copy of Su(var)3-7. (Reuter et al., 1990)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140937 NM_168835 NM_001275171 RefSeq (Proteins) • NP_649194 NP_730497 NP_001262100 DDBJ / EMBL / GenBank • AAF49051 AAF49052 AAM11190 AGB94793 AI512936 AW943760 AY094837 CZ483143 Entrez Gene - A searchable database of RefSeq genes. • 40217 UniProtKB/Swiss-Prot • Q9VW97 UniProtKB/TrEMBL • B7Z0G7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Amine oxidase (IPR002937) SWIRM domain (IPR007526) Histone lysine-specific demethylase (IPR017366) Homeodomain-like (IPR009057) Winged helix-turn-helix DNA-binding domain (IPR011991) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD45081
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0260397 DroID - A comprehensive database of gene and protein interactions. • FBgn0260397 DRSC - Results from RNAi screens. • FBgn0260397 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0260397 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0260397 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40217 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/lsd_suvar3-3.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40217 modMine - Data generated by the modENCODE project. • FBgn0260397
Synonyms & Secondary IDs ( 16 )
Reported As
Symbol Synonym	CG17149 (Rudolph et al., 2007, Curtis et al., 2011, Dorus et al., 2006, Singh, 2007.3.5, Matthews, 2008.4.15, Hueber et al., 2007, Ni et al., 2011.7.19, Di Stefano et al., 2007, Keleman et al., 2009.8.5, Haussmann et al., 2008, Ni et al., 2010.12.1) dLsd1 (Di Stefano et al., 2007, Curtis et al., 2008, Di Stefano et al., 2011, Meier et al., 2012) Dmel/HDM (Singh and Elefant, 2007) Dmel/LSD1 (Singh and Elefant, 2007) Dmel\LSD1 (Singh, 2007.3.5) Hdm   lsd1 (Curtis et al., 2011) Lsd1 (Di Stefano et al., 2007, Eliazer et al., 2011) Su(var)3-3 (Doheny et al., 2008, Gan et al., 2010, Joanis and Lloyd, 2002, Curtis et al., 2008, Baig et al., 2010) SU(VAR)3-3 (Rudolph et al., 2007) Suvar(3)3 (Bashaw and Baker, 1996, Reuter and Spierer, 1992) Su-var(3)3 (Wustmann et al., 1989, Reuter et al., 1986)
Name Synonym	CG17149 (Singh, 2007.3.5) Flavoprotein (Dallman et al., 2004) Histone demethylase (Singh and Elefant, 2007) histone lysine-specific demethylase 1 (Eliazer et al., 2011) Suppressor of variegation 3-3 (Baig et al., 2010)
Secondary FlyBase IDs
	FBgn0003594 FBgn0036954 FBgn0036955 FBgn0259698
References ( 55 )
Generate a list of	All references relating to this gene ( 55 )
List References by type	Research paper  ( 25 ) Supplementary material  ( 4 ) Review  ( 3 ) Personal communication to FlyBase  ( 14 ) Abstract  ( 2 ) FlyBase analysis  ( 2 ) Website  ( 1 ) Book  ( 1 ) Curated genome annotation  ( 2 ) DNA/RNA sequence record  ( 1 )
Recent research papers ( 5 )
	Meier et al., 2012, PLoS Genet. 8(5): e1002676 LINT, a Novel dL(3)mbt-Containing Complex, Represses Malignant Brain Tumour Signature Genes. [FBrf0218194] Curtis et al., 2011, Dev. Biol. 350(2): 534--547 Histone lysine demethylases function as co-repressors of SWI/SNF remodeling activities during Drosophila wing development. [FBrf0212876] Di Stefano et al., 2011, Genes Dev. 25(1): 17--28 Functional antagonism between histone H3K4 demethylases in vivo. [FBrf0212709] Eliazer et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(17): 7064--7069 Loss of lysine-specific demethylase 1 nonautonomously causes stem cell tumors in the Drosophila ovary. [FBrf0213593] Mulligan et al., 2011, Mol. Cell 42(5): 689--699 A SIRT1-LSD1 Corepressor Complex Regulates Notch Target Gene Expression and Development. [FBrf0213865] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...