dLsd1, Lsd1, Suvar(3)3, Histone demethylase, Su-var(3)3
homolog of the human LSD1 amine oxidase - demethylates H3K4me2 and H3K4me1 and facilitates subsequent H3K9 methylation by SU(VAR)3-9 - dictates the distinction between euchromatic and heterochromatic domains during early embryogenesis
Please see the JBrowse view of Dmel\Su(var)3-3 for information on other features
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Gene model reviewed during 5.43
Gene model reviewed during 5.45
The group(s) of polypeptides indicated below share identical sequence to each other.
Component of a complex that contains at least Rpd3, CoRest and Su(var)3-3/Hdm.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Su(var)3-3 using the Feature Mapper tool.
Comment: maternally deposited
Su(var)3-3 is expressed uniformly throughout the developing wing in both vein and intervein cells in stage P7 pupal wings.
Su(var)3-3 is expressed throughout the germarium and is predominantly localized in the nucleus. Expression appears highest in the germline stem cells, but is also present in the escort cells and follicle cells of the germarium.
GBrowse - Visual display of RNA-Seq signals
View Dmel\Su(var)3-3 in GBrowse 23-47
3-47
3-43.5
3-46.6 +/- 0.2
3-46.7 +/- 2.3
3-46.6
Mapping on 3L based on its absence from induced C(3R)RM derivatives of Su(var)3-3-bearing chromosomes.
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
monoclonal
polyclonal
Source for identity of: Hdm CG17149
Source for merge of: Su(var)3-3 Hdm
The "Su(var)3-3" gene was previously mistakenly merged with the CG17147 gene in FlyBase. This error has been corrected and CG17147 has been split out into a separate gene from Su(var)3-3. The "Su(var)3-3" gene actually corresponds to the "CG17149" annotation.
lid and Su(var)3-3 have opposing functions in the establishment of euchromatin and heterochromatin boundaries; Su(var)3-3 promotes heterochromatin formation, while lid promotes euchromatin formation.
Su(var)3-3 and Wow represent different complementation groups based on their effects on w mutations and fertility/viability.
No additive effect of mutant alleles with mod alleles on suppression of position effect variegation at In(1)wm4.
Suppression of In(1)wm4 position effect variegation by Su(var)3-3 was reversed by a supernumerary copy of Su(var)3-7.