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Gene Dmel\gwl

General Information
Symbol	Dmel\gwl	Species	D. melanogaster
Name	greatwall	Annotation symbol	CG7719
Feature type	protein_coding_gene	FlyBase ID	FBgn0260399
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	Pk91C, CG7719-related
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	91C5-91C6	Sequence location	3R:14,572,094..14,576,082 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene greatwall is referred to in FlyBase by the symbol Dmel\gwl (CG7719, FBgn0260399). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process: regulation of meiosis; female meiosis I; regulation of mitotic centrosome separation; regulation of mitotic cell cycle; mitosis; regulation of mitosis; chromosome condensation. 26 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; organ system; organelle; multicellular structure; intracellular non-membrane-bounded organelle; intracellular organelle part; cytoplasmic part; cell cycle; external compound sense organ; adult segment. It has one annotated transcript and one annotated polypeptide. Protein features are: AGC-kinase, C-terminal; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase, catalytic domain; Serine/threonine-protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1631785_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of gwl. Gene sequence location is 3R:14572094..14576082.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Transgenic Constructs P{UASp-gwl.MYC} P{UASp-gwl.MYC.K87R} References Wang et al., 2011, PLoS Genet. 7(8): e1002227 Alleles gwl[K87R.Scer\UAS.P\T.T:Hsap\MYC] gwl[Scer\UAS.P\T.T:Hsap\MYC]
FB2012_01	References Guenin et al., 2010, BMC Genomics 11: 47 Rangone et al., 2011, PLoS Genet. 7(8): e1002225 Sequence features BKN50051 BKN20787 HFA16305 BKN51041
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 91C5-91C6   Limits computationally determined from genome sequence between P{PZ}sprd05284 and P{PZ}cdi07013&P{lacW}nosj3B6
Experimentally Determined Cytological Location
Cytogenetic map Notes References 91C-91C   (determined by in situ hybridisation)   (Kalderon and Rubin, 1988)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\gwl for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) gwl-RA FBtr0083674  NM_080121   3097   846
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein gwl-PA   FBpp0083089   93.5   846   6.74     NP_524860   AAF55594
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) AGC-kinase, C-terminal (IPR000961) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Serine/threonine-protein kinase-like domain (IPR017442)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201414   AA202438   AA390488   AA439782   AA816651   AA978536   AE014297 AAF55594   AI455607   AQ025101   AW943260   AY058648 AAL13877   BF505638   BI234812   BI235351   BI237326   BI482659   BI483294   CO177210   CO185703   CO269041   CO270201   CO300595   CO303838   CO321450   CO326555   CO345235   CQ847768   CZ487259   CZ487260   EC051021   EC052490   EC053985   EC054482   EC056192   EC056311   EC056459   EC057110   EC062955   EC069609   EC075739   EC082566   EC090456   EC212387   EC236868   EC246083   EC252694   EV590854
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q95TN8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4   organism   • yolk plasma | posterior (Lecuyer et al., 2007) embryonic stage 5   pole cell   (Lecuyer et al., 2007)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0260399    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0260399 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0260399 expression level Developmental Stage   Expression Level embryo 00-02hr    11802 embryo 02-04hr    5061 embryo 04-06hr    4261 embryo 06-08hr    3094 embryo 08-10hr    3935 embryo 10-12hr    2105 embryo 12-14hr    1765 embryo 14-16hr    2297 embryo 16-18hr    1948 embryo 18-20hr    776 embryo 20-22hr    2776 embryo 22-24hr    2880 larva L1    64 larva L2    65 larva L3 12hr old    70 larva L3 puffstage 1-2    230 larva L3 puffstage 3-6    336 larva L3 puffstage 7-9    485 white prepupae new    513 white prepupae 12hr    659 white prepupae 24hr    615 pupae 2d postWPP    344 pupae 3d postWPP    181 pupae 4d postWPP    253 adult male 01day    231 adult male 05day    359 adult male 30day    338 adult female 01day    3885 adult female 05day    7739 adult female 30day    7822 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (11802) embryo 02-04hr  (5061) embryo 04-06hr  (4261) embryo 06-08hr  (3094) embryo 08-10hr  (3935) embryo 10-12hr  (2105) embryo 12-14hr  (1765) embryo 14-16hr  (2297) embryo 16-18hr  (1948) embryo 18-20hr  (776) embryo 20-22hr  (2776) embryo 22-24hr  (2880) larva L1    64 larva L2    65 larva L3 12hr old    70 larva L3 puffstage 1-2  (230) larva L3 puffstage 3-6  (336) larva L3 puffstage 7-9  (485) white prepupae new  (513) white prepupae 12hr  (659) white prepupae 24hr  (615) pupae 2d postWPP  (344) pupae 3d postWPP  (181) pupae 4d postWPP  (253) adult male 01day  (231) adult male 05day  (359) adult male 30day  (338) adult female 01day  (3885) adult female 05day  (7739) adult female 30day  (7822) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (11802) embryo 02-04hr  (5061) embryo 04-06hr  (4261) embryo 06-08hr  (3094) embryo 08-10hr  (3935) embryo 10-12hr  (2105) embryo 12-14hr  (1765) embryo 14-16hr  (2297) embryo 16-18hr  (1948) embryo 18-20hr    776 embryo 20-22hr  (2776) embryo 22-24hr  (2880) larva L1    64 larva L2    65 larva L3 12hr old    70 larva L3 puffstage 1-2    230 larva L3 puffstage 3-6    336 larva L3 puffstage 7-9    485 white prepupae new    513 white prepupae 12hr    659 white prepupae 24hr    615 pupae 2d postWPP    344 pupae 3d postWPP    181 pupae 4d postWPP    253 adult male 01day    231 adult male 05day    359 adult male 30day    338 adult female 01day  (3885) adult female 05day  (7739) adult female 30day  (7822) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (11802) embryo 02-04hr    5061 embryo 04-06hr    4261 embryo 06-08hr    3094 embryo 08-10hr    3935 embryo 10-12hr    2105 embryo 12-14hr    1765 embryo 14-16hr    2297 embryo 16-18hr    1948 embryo 18-20hr    776 embryo 20-22hr    2776 embryo 22-24hr    2880 larva L1    64 larva L2    65 larva L3 12hr old    70 larva L3 puffstage 1-2    230 larva L3 puffstage 3-6    336 larva L3 puffstage 7-9    485 white prepupae new    513 white prepupae 12hr    659 white prepupae 24hr    615 pupae 2d postWPP    344 pupae 3d postWPP    181 pupae 4d postWPP    253 adult male 01day    231 adult male 05day    359 adult male 30day    338 adult female 01day    3885 adult female 05day    7739 adult female 30day    7822 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    11802 embryo 02-04hr    5061 embryo 04-06hr    4261 embryo 06-08hr    3094 embryo 08-10hr    3935 embryo 10-12hr    2105 embryo 12-14hr    1765 embryo 14-16hr    2297 embryo 16-18hr    1948 embryo 18-20hr    776 embryo 20-22hr    2776 embryo 22-24hr    2880 larva L1    64 larva L2    65 larva L3 12hr old    70 larva L3 puffstage 1-2    230 larva L3 puffstage 3-6    336 larva L3 puffstage 7-9    485 white prepupae new    513 white prepupae 12hr    659 white prepupae 24hr    615 pupae 2d postWPP    344 pupae 3d postWPP    181 pupae 4d postWPP    253 adult male 01day    231 adult male 05day    359 adult male 30day    338 adult female 01day    3885 adult female 05day    7739 adult female 30day    7822 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0260399 expression level Developmental Stage   Expression Level embryo 00-02hr    11802 embryo 02-04hr    5061 embryo 04-06hr    4261 embryo 06-08hr    3094 embryo 08-10hr    3935 embryo 10-12hr    2105 embryo 12-14hr    1765 embryo 14-16hr    2297 embryo 16-18hr    1948 embryo 18-20hr    776 embryo 20-22hr    2776 embryo 22-24hr    2880 larva L1    64 larva L2    65 larva L3 12hr old    70 larva L3 puffstage 1-2    230 larva L3 puffstage 3-6    336 larva L3 puffstage 7-9    485 white prepupae new    513 white prepupae 12hr    659 white prepupae 24hr    615 pupae 2d postWPP    344 pupae 3d postWPP    181 pupae 4d postWPP    253 adult male 01day    231 adult male 05day    359 adult male 30day    338 adult female 01day    3885 adult female 05day    7739 adult female 30day    7822 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (11802) embryo 02-04hr  (5061) embryo 04-06hr  (4261) embryo 06-08hr  (3094) embryo 08-10hr  (3935) embryo 10-12hr  (2105) embryo 12-14hr  (1765) embryo 14-16hr  (2297) embryo 16-18hr  (1948) embryo 18-20hr  (776) embryo 20-22hr  (2776) embryo 22-24hr  (2880) larva L1    64 larva L2    65 larva L3 12hr old    70 larva L3 puffstage 1-2  (230) larva L3 puffstage 3-6  (336) larva L3 puffstage 7-9  (485) white prepupae new  (513) white prepupae 12hr  (659) white prepupae 24hr  (615) pupae 2d postWPP  (344) pupae 3d postWPP  (181) pupae 4d postWPP  (253) adult male 01day  (231) adult male 05day  (359) adult male 30day  (338) adult female 01day  (3885) adult female 05day  (7739) adult female 30day  (7822) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (11802) embryo 02-04hr  (5061) embryo 04-06hr  (4261) embryo 06-08hr  (3094) embryo 08-10hr  (3935) embryo 10-12hr  2105 embryo 12-14hr  1765 embryo 14-16hr  2297 embryo 16-18hr  1948 embryo 18-20hr    776 embryo 20-22hr  (2776) embryo 22-24hr  (2880) larva L1    64 larva L2    65 larva L3 12hr old    70 larva L3 puffstage 1-2    230 larva L3 puffstage 3-6    336 larva L3 puffstage 7-9    485 white prepupae new    513 white prepupae 12hr    659 white prepupae 24hr    615 pupae 2d postWPP    344 pupae 3d postWPP    181 pupae 4d postWPP    253 adult male 01day    231 adult male 05day    359 adult male 30day    338 adult female 01day  (3885) adult female 05day  (7739) adult female 30day  (7822) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  11802 embryo 02-04hr    5061 embryo 04-06hr    4261 embryo 06-08hr    3094 embryo 08-10hr    3935 embryo 10-12hr    2105 embryo 12-14hr    1765 embryo 14-16hr    2297 embryo 16-18hr    1948 embryo 18-20hr    776 embryo 20-22hr    2776 embryo 22-24hr    2880 larva L1    64 larva L2    65 larva L3 12hr old    70 larva L3 puffstage 1-2    230 larva L3 puffstage 3-6    336 larva L3 puffstage 7-9    485 white prepupae new    513 white prepupae 12hr    659 white prepupae 24hr    615 pupae 2d postWPP    344 pupae 3d postWPP    181 pupae 4d postWPP    253 adult male 01day    231 adult male 05day    359 adult male 30day    338 adult female 01day    3885 adult female 05day    7739 adult female 30day    7822 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    11802 embryo 02-04hr    5061 embryo 04-06hr    4261 embryo 06-08hr    3094 embryo 08-10hr    3935 embryo 10-12hr    2105 embryo 12-14hr    1765 embryo 14-16hr    2297 embryo 16-18hr    1948 embryo 18-20hr    776 embryo 20-22hr    2776 embryo 22-24hr    2880 larva L1    64 larva L2    65 larva L3 12hr old    70 larva L3 puffstage 1-2    230 larva L3 puffstage 3-6    336 larva L3 puffstage 7-9    485 white prepupae new    513 white prepupae 12hr    659 white prepupae 24hr    615 pupae 2d postWPP    344 pupae 3d postWPP    181 pupae 4d postWPP    253 adult male 01day    231 adult male 05day    359 adult male 30day    338 adult female 01day    3885 adult female 05day    7739 adult female 30day    7822 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0260399    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0260399 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0260399 expression level Tissue   Expression Level Larval Central Nervous System    65.375 Larval Midgut    3.3 Larval Hindgut    3.2 Larval Malpighian Tubules    5.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    15.4 Larval Carcass    9.1 Adult Head    2.5 Adult Eye    4 Adult Brain    0.9 Adult Thoracic-Abdominal Ganglion    2.4 Adult Crop    5.2 Adult Midgut    3.2 Adult Hindgut    2.2 Adult Malpighian Tubules    6.9 Adult Fat Body    5.6 Adult Salivary Gland    7.7 Adult Heart    0.475 Adult VirginFemale Spermatheca    8.1 Adult InseminatedFemale Spermatheca    5.1 Adult Ovary    605.5 Adult Testis    95.2 Adult Male Accessory Gland    4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    65.375 Larval Midgut    3.3 Larval Hindgut    3.2 Larval Malpighian Tubules    5.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    15.4 Larval Carcass    9.1 Adult Head    2.5 Adult Eye    4 Adult Brain    0.9 Adult Thoracic-Abdominal Ganglion    2.4 Adult Crop    5.2 Adult Midgut    3.2 Adult Hindgut    2.2 Adult Malpighian Tubules    6.9 Adult Fat Body    5.6 Adult Salivary Gland    7.7 Adult Heart    0.475 Adult VirginFemale Spermatheca    8.1 Adult InseminatedFemale Spermatheca    5.1 Adult Ovary  (605.5) Adult Testis    95.2 Adult Male Accessory Gland    4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    65.375 Larval Midgut    3.3 Larval Hindgut    3.2 Larval Malpighian Tubules    5.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    15.4 Larval Carcass    9.1 Adult Head    2.5 Adult Eye    4 Adult Brain    0.9 Adult Thoracic-Abdominal Ganglion    2.4 Adult Crop    5.2 Adult Midgut    3.2 Adult Hindgut    2.2 Adult Malpighian Tubules    6.9 Adult Fat Body    5.6 Adult Salivary Gland    7.7 Adult Heart    0.475 Adult VirginFemale Spermatheca    8.1 Adult InseminatedFemale Spermatheca    5.1 Adult Ovary    605.5 Adult Testis    95.2 Adult Male Accessory Gland    4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    65.375 Larval Midgut    3.3 Larval Hindgut    3.2 Larval Malpighian Tubules    5.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    15.4 Larval Carcass    9.1 Adult Head    2.5 Adult Eye    4 Adult Brain    0.9 Adult Thoracic-Abdominal Ganglion    2.4 Adult Crop    5.2 Adult Midgut    3.2 Adult Hindgut    2.2 Adult Malpighian Tubules    6.9 Adult Fat Body    5.6 Adult Salivary Gland    7.7 Adult Heart    0.475 Adult VirginFemale Spermatheca    8.1 Adult InseminatedFemale Spermatheca    5.1 Adult Ovary    605.5 Adult Testis    95.2 Adult Male Accessory Gland    4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0260399 expression level Tissue   Expression Level Larval Central Nervous System    65.375 Larval Midgut    3.3 Larval Hindgut    3.2 Larval Malpighian Tubules    5.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    15.4 Larval Carcass    9.1 Adult Head    2.5 Adult Eye    4 Adult Brain    0.9 Adult Thoracic-Abdominal Ganglion    2.4 Adult Crop    5.2 Adult Midgut    3.2 Adult Hindgut    2.2 Adult Malpighian Tubules    6.9 Adult Fat Body    5.6 Adult Salivary Gland    7.7 Adult Heart    0.475 Adult VirginFemale Spermatheca    8.1 Adult InseminatedFemale Spermatheca    5.1 Adult Ovary    605.5 Adult Testis    95.2 Adult Male Accessory Gland    4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    65.375 Larval Midgut    3.3 Larval Hindgut    3.2 Larval Malpighian Tubules    5.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    15.4 Larval Carcass    9.1 Adult Head    2.5 Adult Eye    4 Adult Brain    0.9 Adult Thoracic-Abdominal Ganglion    2.4 Adult Crop    5.2 Adult Midgut    3.2 Adult Hindgut    2.2 Adult Malpighian Tubules    6.9 Adult Fat Body    5.6 Adult Salivary Gland    7.7 Adult Heart    0.475 Adult VirginFemale Spermatheca    8.1 Adult InseminatedFemale Spermatheca    5.1 Adult Ovary  605.5 Adult Testis    95.2 Adult Male Accessory Gland    4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    65.375 Larval Midgut    3.3 Larval Hindgut    3.2 Larval Malpighian Tubules    5.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    15.4 Larval Carcass    9.1 Adult Head    2.5 Adult Eye    4 Adult Brain    0.9 Adult Thoracic-Abdominal Ganglion    2.4 Adult Crop    5.2 Adult Midgut    3.2 Adult Hindgut    2.2 Adult Malpighian Tubules    6.9 Adult Fat Body    5.6 Adult Salivary Gland    7.7 Adult Heart    0.475 Adult VirginFemale Spermatheca    8.1 Adult InseminatedFemale Spermatheca    5.1 Adult Ovary    605.5 Adult Testis    95.2 Adult Male Accessory Gland    4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    65.375 Larval Midgut    3.3 Larval Hindgut    3.2 Larval Malpighian Tubules    5.1 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    15.4 Larval Carcass    9.1 Adult Head    2.5 Adult Eye    4 Adult Brain    0.9 Adult Thoracic-Abdominal Ganglion    2.4 Adult Crop    5.2 Adult Midgut    3.2 Adult Hindgut    2.2 Adult Malpighian Tubules    6.9 Adult Fat Body    5.6 Adult Salivary Gland    7.7 Adult Heart    0.475 Adult VirginFemale Spermatheca    8.1 Adult InseminatedFemale Spermatheca    5.1 Adult Ovary    605.5 Adult Testis    95.2 Adult Male Accessory Gland    4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    2.5   NA  Eye    4   NA  Brain    0.9   65.375  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    2.4   NA  Crop    5.2   3.3  Midgut    3.2   3.2  Hindgut    2.2   5.1  Malpighian Tubules    6.9   no informative data  Fat Body    5.6   no informative data  Salivary Gland    7.7   NA  Heart    0.475   15.4  Trachea    NA   NA  VirginFemale Spermatheca    8.1   NA  InseminatedFemale Spermatheca    5.1   NA  Ovary    605.5   NA  Testis    95.2   NA  Male Accessory Gland    4   9.1  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_01
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0260399
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 gwlGD9947 semi-lethal gwl2 gwl3a gwl6a semi-viable (with gwl6a) gwlSr3 semi-viable (with gwlSr3) gwl6a gwlSr6 semi-viable (with gwlSr6) gwlSr3 viable gwlscant viable, with Scer\GAL4pnr-MD237 gwlGD9947 viable (with Df(3L)gwl3b) gwlSr18 Sterility Allele female fertile (with gwl2) gwlSr3 gwlSr6 female fertile (with gwl3a) gwlSr3 gwlSr6 female fertile (with gwl6a) gwlSr3 gwlSr6 female fertile (with gwlSr3) gwl2 gwl3a gwl6a female fertile (with gwlSr6) gwl2 gwl3a gwl6a female sterile gwlscant female sterile (with Df(3L)gwl3b) gwlSr18 fertile (with gwl2) gwlSr6 fertile (with gwl3a) gwlSr6 fertile (with gwl6a) gwlSr6 fertile (with gwlSr6) gwl2 gwl3a gwl6a sterile gwl6a gwlSr3 gwlSr6 sterile (with gwl6a) gwlSr3 sterile (with gwlSr3) gwl6a Other Phenotypes Allele eclosion rhythm defective gwlSr3 eclosion rhythm defective (with gwl6a) gwlSr3 eclosion rhythm defective (with gwlSr3) gwl6a gwlSr6 eclosion rhythm defective (with gwlSr6) gwlSr3 meiotic cell cycle defective (with Df(3L)gwl3b) gwlSr18 mitotic cell cycle defective gwl716 gwldsRNA.cYa gwlunspecified mitotic cell cycle defective (with Df(3L)gwl3b) gwl6a mitotic cell cycle defective (with gwl6a) gwlSr3 mitotic cell cycle defective (with gwlSr3) gwl6a gwlSr6 mitotic cell cycle defective (with gwlSr6) gwlSr3 neuroanatomy defective gwldsRNA.cIa neuroanatomy defective | larval stage, with Scer\GAL4elav-C155 gwlEP515 Phenotype manifest in Allele anterior fascicle & synapse, with Scer\GAL4elav-C155 gwlEP515 anterior fascicle & synapse | supernumerary, with Scer\GAL4elav-C155 gwlEP515 centrosome (with Df(3L)gwl3b) gwlSr18 chromatin gwlSr6 chromatin (with Df(3L)gwl3b) gwl6a chromatin (with gwl6a) gwlSr3 chromatin (with gwlSr3) gwlSr6 gwl6a chromatin (with gwlSr6) gwlSr3 chromosome gwldsRNA.cYa condensed chromosome gwl716 gwlunspecified egg (with Df(3L)gwl3b) gwlSr18 embryonic/larval brain gwlscant embryonic/larval brain | larval stage, with Scer\GAL41407 gwlGD9947 eye gwlSr3 eye (with gwl6a) gwlSr3 eye (with gwlSr3) gwlSr6 gwl6a eye (with gwlSr6) gwlSr3 gonad gwlSr3 gonad (with gwl6a) gwlSr3 gonad (with gwlSr3) gwlSr6 gwl6a gonad (with gwlSr6) gwlSr3 intersegmental nerve, with Scer\GAL4elav-C155 gwlEP515 longitudinal connective gwldsRNA.cIa macrochaeta gwlSr3 macrochaeta (with gwl6a) gwlSr3 macrochaeta (with gwlSr3) gwlSr6 gwl6a macrochaeta (with gwlSr6) gwlSr3 mitotic cell cycle gwldsRNA.cYa mitotic cell cycle | third instar larval stage gwl716 gwlunspecified neuroblast & mitotic cell cycle gwl716 gwlunspecified oocyte (with Df(3L)gwl3b) gwlSr18 segmental nerve | embryonic stage gwldsRNA.cIa spindle (with Df(3L)gwl3b) gwlSr18 ventral nerve cord commissure gwldsRNA.cIa wing margin gwlSr3 wing margin (with gwl6a) gwlSr3 wing margin (with gwlSr3) gwlSr6 gwl6a wing margin (with gwlSr6) gwlSr3
Classical Alleles ( 16 )
For All Classical Alleles Show
Allele of gwl Class Mutagen Stocks Known lesion gwlEP515 P-element activity 1 Yes gwlf04701 piggyBac transposase 1 -- gwlMB01301 1 -- gwl1028 ethyl methanesulfonate 0 Yes gwl180 0 Yes gwl2970 0 Yes gwl2 P-element activity 0 Yes gwl3a P-element activity 0 Yes gwl6a loss of function allele P-element activity 0 Yes gwl716 0 Yes gwl873 0 Yes gwlscant gain of function allele ethyl methanesulfonate 0 Yes gwlSr18 hypomorphic allele - genetic evidence 0 Yes gwlSr3 hypomorphic allele - genetic evidence X ray 0 Yes gwlSr6 hypomorphic allele - genetic evidence X ray 0 Yes gwlunspecified 0 --
Alleles Carried on Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Allele of gwl Class Mutagen Stocks Known lesion gwlGD9947 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes gwlGL00091 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes gwlHMS00834 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes gwldsRNA.cIa in vitro construct - RNAi 0 Yes gwldsRNA.cYa in vitro construct - RNAi 0 Yes gwlK87R.Scer\UAS.P\T.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes gwlK97M.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes gwlL.Scer\UAS in vitro construct - regulatory fusion 0 Yes gwlS.Scer\UAS in vitro construct - regulatory fusion 0 Yes gwlScer\UAS.P\T.T:Hsap\MYC in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)gwl3b (Archambault et al., 2007) Df(3R)Exel6181 (Ryder, 2004.4.26, Archambault et al., 2007)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9947} NA P{TRiP.GL00091} NA P{TRiP.HMS00834} NA P{UAS-gwl-short} NA P{UASp-gwl.K97M} NA P{UASp-gwl.Long} NA P{UASp-gwl.MYC.K87R} NA P{UASp-gwl.MYC} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}gwlEP515 NA miscellaneous insertions PBac{WH}gwlf04701 NA insertion of enhancer trap binary system Mi{ET1}gwlMB01301 No
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
chromosome condensation inferred from mutant phenotype (Yu et al., 2004) female meiosis I inferred from mutant phenotype (Archambault et al., 2007) mitosis inferred from mutant phenotype (Yu et al., 2002) regulation of meiosis inferred from mutant phenotype (Archambault et al., 2007) regulation of mitosis inferred from mutant phenotype (Archambault et al., 2007) regulation of mitotic cell cycle inferred from mutant phenotype (Yu et al., 2004) regulation of mitotic centrosome separation inferred from mutant phenotype (Archambault et al., 2007)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR000961, InterPro:IPR002290 (FlyBase Curators et al., 2004-) protein kinase activity non-traceable author statement (Morrison et al., 2000) protein serine/threonine kinase activity inferred from electronic annotation with InterPro:IPR000961, InterPro:IPR008271 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Kalderon and Rubin, 1988)
Biological Process
CV term Evidence References
protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR000961, InterPro:IPR002290, InterPro:IPR008271 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Kalderon and Rubin, 1988) non-traceable author statement (Morrison et al., 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions gwl allele Gene References unspecified polo (Glover, 1995)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0260399 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45969
Orthologs
Genome-wide drosophilid orthologs	Dana\GF23215 Dere\GG23066 Dgri\GH14461 Dmoj\GI22962 Dper\GL23525 Dpse\GA20542 Dsec\GM17889 Dvir\GJ14542 Dwil\GK22740 Dyak\GE25560
Curated drosophilid orthologs	Dpse\GA20542
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL002569-PA Aedes aegypti (mosquito) AGAP001636-PA Anopheles gambiae (mosquito) XP_394554.1 Apis mellifera (honey bee) 10540 Batrachochytrium dendrobatidis (chytrid fungus) XP_001902914.1 Brugia malayi (roundworm nematode) ENSBTAP00000022950 Bos taurus (bovine) ENSCAFP00000006520 Canis familiaris (dog) ENSCINP00000025195 Ciona intestinalis (sea squirt) CPIJ002365 Culex pipens (mosquito) ENSCPOP00000013474 Cavia porcellus (guinea pig) ENSCSAVP00000015373 Ciona savignyi (sedentary tunicate) ENSDARP00000072407 Danio rerio (zebra fish) ENSECAP00000010501 Equus caballus (horse) ENSGACP00000006718 Gymnopilus aculeatus (mushroom) ENSGALP00000012119 Gallus gallus (chicken) 82389 Hypsipyla robusta (cedar shoot borer) ENSP00000365107 Homo sapiens (human) 115088 Lottia gigantea (owl limpet) 8114 Monocosta brevicollis (choanoflagellate) ENSMODP00000010473 Monodelphis domestica (gray opossum) ENSMMUP00000021548 Macaca mulatta (rhesus monkey) ENSMUSP00000028119 Mus musculus (house mouse) 31039 Nematostella vectensis (starlet anemone) ENSOANP00000009611 Ornithorynchus anatinus (platypus) ENSORLP00000016083 Oryzias latipes (japanese killifish) 4157 Ostreococcus tauri (green alga) PHUM002951-PA Pediculus humanus (human body louse) ENSPPYP00000002522 Pongo pygmaeus (orangutan) ENSPTRP00000004033 Pan troglodytes (chimpanzee) ENSRNOP00000023698 Rattus norvegicus (norway rat) Smp_174820 Schistosoma mansoni (trematode parasite) ENSTNIP00000016647 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000028028 Takifugu rubripes (pufferfish Takifugu) 94262.m00278 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000040639 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14888 NV11319 LH18597 ISCW015651 FBgn0242624 FBgn0224717 FBgn0201753 FBgn0190754 FBgn0190753 FBgn0172796 JGI_V11_328306 FBgn0080536 FBgn0161115 FBgn0145689 FBgn0121937 FBgn0115223 FBgn0100209 CPIJ002365 BGIBMGA003733 BGIBMGA003734 ACYPI004551 GB18540 AGAP001636 AAEL002569 PHUM380500 GLEAN_03692
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	23052 y1 w67c23; Mi{ET1}gwlMB01301 17174 w1118; P{EP}gwlEP515/TM6B, Tb1 35212 y1 sc* v1; P{TRiP.GL00091}attP2 34525 y1 sc* v1; P{TRiP.HMS00834}attP2
Harvard	- PBac{WH}gwlf04701
VDRC	v21046 w1118; P{GD9947}v21046
Genomic Clones ( 2 )
	BACR01F15 BACR40J10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 40 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD35132
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT07907 LD02624 LD03131 LD04412 LD09348 LD14440 LD30784 RE30570 RE31186 RE33539 RE65376 RE66166
Other clones	57754 60911 70934 80992 103235 194871 214251.58 CK01.8A.H7 CK01.67A.H8 CK01.122C.F11 Dmel_neb_000041_0350_3756 EC051021 EC052490 EC053985 EC054482 EC056192 EC056311 EC056459 EK010932 EK052764 EK093424 EK097907 EK178651 EK185717 EK242922 EP04205 EP21651
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0260399 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45969
Antibody Information
	monoclonal (Archambault et al., 2007)
Other Information
Discoverer
Etymology
	The gene is named "greatwall" because the mutant phenotype suggests a role in protecting chromosome structure. (Yu et al., 2004)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: gwl Pk91C (Yu, 2002.3.29)
Source for database merge of	Source for merge of: gwl scant (Archambault et al., 2007) Source for merge of: Pk91C CG7719 (Bayraktaroglu, 2000.11.2)
Additional comments
Other Comments
	gwl enhances mitotic defects resulting from a decrease in polo function. (Archambault et al., 2007) gwl is required for sister chromatid cohesion in female meiosis I. (Archambault et al., 2007) gwl has multiple roles in progression through mitosis and meiosis. (Archambault et al., 2007) When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of G2/M phase cells, an increase in mitotic index, a decrease in the ratio of cells in prometaphase and metaphase versus the total number of mitotic cells, a whole range of mitotic abnormalities, spindle abnormalities, chromosome abnormalities, chromosome segregation defects are seen. (Bettencourt-Dias et al., 2004) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Mutants exhibit a high mitotic index and metaphase arrest. (Yu et al., 2002) Five genes essential for cell cycle progression, polo, mgr, asp, stg and gnu, are recombined onto a single chromosome, EMS mutations are isolated that fail to complement this chromosome. Genes encoding proteins that interact with the products of any of the five genes are isolated. (White-Cooper et al., 1996) Embryos from mothers transheterozygous for mutations in polo and scant show bipolar spindles that have a centrosome only at one pole. (Glover, 1995) Isolated from a genomic library using a Pka-C1 probe. (Kalderon and Rubin, 1988) gwl may encode a protein kinase. (Kalderon and Rubin, 1988) Gene in D.melanogaster encoding product related (by sequence comparison) to the serine-threonine protein kinases of mammals. Isolated from Drosophila clones obtained with mammalian probes.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080121 RefSeq (Proteins) • NP_524860 DDBJ / EMBL / GenBank • AAF55594 AAL13877 AI455607 AQ025101 AW943260 AY058648 CQ847768 CZ487259 CZ487260 Entrez Gene - A searchable database of RefSeq genes. • 45969 UniProtKB/TrEMBL • Q95TN8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) AGC-kinase, C-terminal (IPR000961) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Serine/threonine-protein kinase-like domain (IPR017442)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0260399 DRSC - Results from RNAi screens. • FBgn0260399 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0260399 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0260399 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45969 InParanoid A subset of ortholog calls from InParanoid. • AAEL002569-PA Aedes aegypti (mosquito) AGAP001636-PA Anopheles gambiae (mosquito) XP_394554.1 Apis mellifera (honey bee) 10540 Batrachochytrium dendrobatidis (chytrid fungus) XP_001902914.1 Brugia malayi (roundworm nematode) ENSBTAP00000022950 Bos taurus (bovine) ENSCAFP00000006520 Canis familiaris (dog) ENSCINP00000025195 Ciona intestinalis (sea squirt) CPIJ002365 Culex pipens (mosquito) ENSCPOP00000013474 Cavia porcellus (guinea pig) ENSCSAVP00000015373 Ciona savignyi (sedentary tunicate) ENSDARP00000072407 Danio rerio (zebra fish) ENSECAP00000010501 Equus caballus (horse) ENSGACP00000006718 Gymnopilus aculeatus (mushroom) ENSGALP00000012119 Gallus gallus (chicken) 82389 Hypsipyla robusta (cedar shoot borer) ENSP00000365107 Homo sapiens (human) 115088 Lottia gigantea (owl limpet) 8114 Monocosta brevicollis (choanoflagellate) ENSMODP00000010473 Monodelphis domestica (gray opossum) ENSMMUP00000021548 Macaca mulatta (rhesus monkey) ENSMUSP00000028119 Mus musculus (house mouse) 31039 Nematostella vectensis (starlet anemone) ENSOANP00000009611 Ornithorynchus anatinus (platypus) ENSORLP00000016083 Oryzias latipes (japanese killifish) 4157 Ostreococcus tauri (green alga) PHUM002951-PA Pediculus humanus (human body louse) ENSPPYP00000002522 Pongo pygmaeus (orangutan) ENSPTRP00000004033 Pan troglodytes (chimpanzee) ENSRNOP00000023698 Rattus norvegicus (norway rat) Smp_174820 Schistosoma mansoni (trematode parasite) ENSTNIP00000016647 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000028028 Takifugu rubripes (pufferfish Takifugu) 94262.m00278 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000040639 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/greatwall.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45969 modMine - Data generated by the modENCODE project. • FBgn0260399 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14888 NV11319 LH18597 ISCW015651 FBgn0242624 FBgn0224717 FBgn0201753 FBgn0190754 FBgn0190753 FBgn0172796 JGI_V11_328306 FBgn0080536 FBgn0161115 FBgn0145689 FBgn0121937 FBgn0115223 FBgn0100209 CPIJ002365 BGIBMGA003733 BGIBMGA003734 ACYPI004551 GB18540 AGAP001636 AAEL002569 PHUM380500 GLEAN_03692
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	1J (Kalderon and Rubin, 1988, ) anon-WO2004063362.73   CG7719 (Yu et al., 2004, Asha et al., 2003, Yu, 2002.9.17, Ni et al., 2010.12.1, Ni et al., 2011.7.19) CG7719-related (Kraut et al., 2001, Kraut et al., 2001) CT23435 (Morrison et al., 2000) EP0515 (Kraut et al., 2001) gwl (Archambault et al., 2007, Lecuyer et al., 2007, Somma et al., 2008, Mattila et al., 2008, Wang et al., 2011, Guenin et al., 2010) Pk91C (Asha et al., 2003, Yu, 2002.9.17, ) Pk?2   scant
Name Synonym	greatwall (Yu et al., 2002, Archambault et al., 2007, Somma et al., 2008, Wang et al., 2011) Protein kinase-like 91C   scott of the antarctic (Glover, 1995)
Secondary FlyBase IDs
	FBgn0004461 FBgn0015538 FBgn0038650 FBgn0082209
References ( 44 )
Generate a list of	All references relating to this gene ( 44 )
List References by type	Research paper  ( 14 ) Supplementary material  ( 7 ) Review  ( 1 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 4 ) FlyBase analysis  ( 1 ) Patent  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 ) Book  ( 1 )
Recent research papers ( 3 )
	Rangone et al., 2011, PLoS Genet. 7(8): e1002225 Suppression of Scant Identifies Endos as a Substrate of Greatwall Kinase and a Negative Regulator of Protein Phosphatase 2A in Mitosis. [FBrf0214749] Wang et al., 2011, PLoS Genet. 7(8): e1002227 PP2A-Twins Is Antagonized by Greatwall and Collaborates with Polo for Cell Cycle Progression and Centrosome Attachment to Nuclei in Drosophila Embryos. [FBrf0214683] Guenin et al., 2010, BMC Genomics 11: 47 Expression profiling of prospero in the Drosophila larval chemosensory organ: Between growth and outgrowth. [FBrf0210012] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...