kinase that coordinates with Polo for mitotic progression - absence of Gwl during meiosis results in excessive and/or premature Polo activity leading to premature loss of sister chromatid cohesion
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.44
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\gwl using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\gwl in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of G2/M phase cells, an increase in mitotic index, a decrease in the ratio of cells in prometaphase and metaphase versus the total number of mitotic cells, a whole range of mitotic abnormalities, spindle abnormalities, chromosome abnormalities, chromosome segregation defects are seen.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Mutants exhibit a high mitotic index and metaphase arrest.
Five genes essential for cell cycle progression, polo, mgr, asp, stg and gnu, are recombined onto a single chromosome, EMS mutations are isolated that fail to complement this chromosome. Genes encoding proteins that interact with the products of any of the five genes are isolated.
Gene in D.melanogaster encoding product related (by sequence comparison) to the serine-threonine protein kinases of mammals. Isolated from Drosophila clones obtained with mammalian probes.
The gene is named "greatwall" because the mutant phenotype suggests a role in protecting chromosome structure.