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Gene Dmel\elav

General Information
Symbol	Dmel\elav	Species	D. melanogaster
Name	embryonic lethal abnormal vision	Annotation symbol	CG4262
Feature type	protein_coding_gene	FlyBase ID	FBgn0260400
Gene Model Status	Current	Stock availability	38 publicly available
Also Known As	EC7, EG:65F1.2
Genomic Location
Chromosome (arm)	X	Recombination map	1-0--1.15
Cytogenetic map	1B7-1B8	Sequence location	X:406,496..417,259 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene embryonic lethal abnormal vision is referred to in FlyBase by the symbol Dmel\elav (CG4262, FBgn0260400). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: poly(U) RNA binding; RNA binding. There is experimental evidence that it is involved in the biological process: central nervous system development; negative regulation of mRNA 3'-end processing. 75 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; organ system; adult segment; embryonic/larval neuron; external compound sense organ; adult; cell part; rhabdomere; pioneer neuron; EG neuron; thoracic segment; cell projection; peripheral nervous system. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Nucleotide-binding, alpha-beta plait; Paraneoplastic encephalomyelitis antigen; RNA recognition motif domain; Splicing factor ELAV/HuD. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult thoracico-abdominal ganglion. Comments on Affy2 ProbeSet: ProbeSet 1636615_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of elav. Gene sequence location is X:406496..417259.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	elav: embryonic lethal, abnormal vision (J. C. Hall) Embryonic lethal, or in the case of viable and ostensibly hypomorphic alleles, displays poor jumping and flying ability plus aberrant visual physiology and behavior. No morphological abnormalities visible in sections of dying embryos (elav1, elav2, or elav3); however, whole-mount embryos show periodic interruptions in the longitudinal connectives of the CNS and missing commissures especially the posterior ones (Jimenez and Campos-Ortega). elavts1 allows survival to adult stage at 19-25 but viability is reduced and adults usually die soon after eclosion; viability after rearing at 30 is very low and newly emerged adults show poor coordination and die soon; this temperature-sensitive allele also causes morphological abnormalities in the brain, especially in the visual system (after postembryonic shift from 19 to 30 or even following all development at low-temperature); optic chiasma is abnormal and second order optic lobe (medulla) is rotated to aberrant position (Campos et al., 1985); when elavts1 raised at 30, surface of eye is rough and photoreceptor layer abnormal in sections (Campos et al., 1985). Another temperature-sensitive allele elav19 also induces abnormalities of visual system (Homyk et al., 1985); rearing at 29 or high-temperature pulses delivered to pupae, raised otherwise at 20, causes vacuolization of photoreceptors and disorganization of rhabdomeres; high-temperature rearing or pupal pulsing induces severe optic lobe defects (absence of size reduction); electroretinograms of this mutant, raised at high-temperature, are missing light-on and light-off transient spikes (also seen after low-temperature rearing) and have reduction of ERG photoreceptor potential; amplitude of this potential also deteriorates as does deep pseudopupil when adults treated at high-temperature after low-temperature rearing; mosaic analysis (Campos et al., 1985) of elav1 reveals autonomously induced defects in eye morphology, but no effects on other imaginal disc derivatives, and suggests both directly induced defects in optic lobe development, as well as inductively caused CNS defects mediated through expression of this mutation in the eye (i. e., such that the visual system's ganglia are genotypically normal). Lethal "focusing" in these mosaics suggests influence of gene on derivatives of ventral blastoderm. In studies of viable alleles, elav19 and elav20, both of which are temperature-sensitive, flying and jumping ability shown to be especially aberrant after rearing at 29; wing position also aberrant; elavts1 most severe, including having no optomotor response when raised at high (or even low) temperature; temperature-sensitive period for aberrant wing posture in elav19 extends from larval to pupal period (Homyk and Grigliatti). An antibody specific to neuronal nuclei fails to stain neurons of elav-deficient embryos; however, the quantity of antigen does not respond to the number of elav+ genes present (Bier, Ackerman, Barbel, Jan and Jan, 1988, Science 240: 913-16). elav transcripts detected in all postmitotic neurons, from their birth; not seen in embryonic or larval neuroblasts. Also seen in larval eye discs, adult retinas and Johnston's organ of the antennae.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Jacobsson et al., 2009, Mol. Genet. Genomics 282(3): 217--231 Feng et al., 2011, EMBO Rep. 12(2): 157--163 Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593
FB2012_01	Sequence features BKN31144 BKN45273 HFA18772 References Vrailas-Mortimer et al., 2011, Dev. Cell 21(4): 783--795 Houalla et al., 2010, Mol. Brain 3: 19 Albornoz et al., 2008, Gene Expr. Patterns 8(6): 443--451 Vallejo et al., 2011, EMBO J. 30(4): 756--769 Hasegawa et al., 2011, Development 138(5): 983--993 Yamasaki et al., 2011, Genes Cells 16(8): 896--909 Fan et al., 2010, Cell Death Differ. 17(6): 912--921
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 1B7-1B8   Limits computationally determined from genome sequence between P{EP}svrEP356&P{EP}argEP452 and P{EP}DreddEP1412&P{EP}Suv4-20EP1216a
Experimentally Determined Cytological Location
Cytogenetic map Notes References   There is a discrepancy between the in situ localisation (12C) and the molecular localisation based on the flanking sequence (1B5--1B6) for the "l(1)G0031" (elavG0031) line. The available data suggests that it is most likely that the molecular localisation (1B5--1B6) is correct and that the in situs were misinterpreted.   (Schaefer, 2003.12.4) 1B7-1B10   (determined by in situ hybridisation)   (Peter et al., 2002) 1B7-1B10   (determined by in situ hybridisation)   (Schaefer et al., 1999.12.2) 1B5-1B9   (determined by in situ hybridisation)   (Yao and White, 1991) 1B4-1B9   (determined by in situ hybridisation)   (Campos et al., 1987)
Experimentally Determined Recombination Data
Location	1-0--1.15 (Hummel et al., 1999)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\elav for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) elav-RA FBtr0070091  NM_080294   2505   483 elav-RB FBtr0100254  NM_001014713   2599   479 elav-RC FBtr0114366  NM_001144670   2248   479 elav-RD FBtr0307173     7278   483
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein elav-PA   FBpp0070086   50.8   483   9.40     NP_525033   AAF45517 elav-PB   FBpp0099643   50.3   479   9.56     NP_001014713   AAX52472 elav-PC   FBpp0112915   50.3   479   9.56     NP_001138142   ACL82875 elav-PD   FBpp0298002   50.8   483   9.40
Additional Polypeptide Data & Comments
Reported size (kDa)	483 (aa); 50 kD (kD predicted) (Robinow et al., 1988) 483 (aa); 50 (kD observed) (Robinow and White, 1991) 50 (kD observed) (Bier et al., 1988)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • RNA recognition motif domain (IPR000504) Paraneoplastic encephalomyelitis antigen (IPR002343) Splicing factor ELAV/HuD (IPR006548) Nucleotide-binding, alpha-beta plait (IPR012677)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA264693   AA697915   AA951066   AA978889   AE014298 AAF45517   AE014298 AAX52472   AE014298 ACL82875   AI512659   AI519828   AL022139 CAA18091   AL022139 CAB37430   AY051822 AAK93246   BI355984   BI371670   BP558993   BP558994   CK659238   CL528154   CO179347   CO179446   CO179633   CO179642   CO185531   CO186101   CO188388   CO196512   CO196664   CO261940   CO264251   CO265523   CO269738   CO272633   CO272824   CO274016   CO274019   CO274972   CO275572   CO275713   CO278023   CO279848   CO281052   CO282121   CO284321   CO284354   CO286192   CO286916   CO290620   CO290783   CO292670   CO306165   CO306945   CO313127   CO315191   CO315218   CO315278   CO315306   CO316905   CO318208   CO318339   CO318529   CO318675   CO319237   CO319238   CO321353   CO321457   CO322658   CO325107   CO327159   CO328516   CO329765   CO332831   CO333461   CO333642   CO334125   CO341288   CO341700   DQ004736   DQ243913   DQ243914   EC057344   EC058502   EC059225   EC060801   EC064036   EC065571   EC065894   EC066800   EC067147   EC068324   EC074434   EC076545   EC076943   EC078049   EC078209   EC078245   EC083731   EC084583   EC084987   EC086614   EC089464   EC089948   EC091183   EC196028   EC197450   EC198110   EC198574   EC198901   EC201998   EC203852   EC203865   EC205467   EC206104   EC207449   EC208157   EC208721   EC209294   EC212267   EC216434   EC217127   EC217232   EC219258   EC220172   EC223472   EC223741   EC227217   EC227467   EC228239   EC228784   EC230412   EC230458   EC231240   EC231965   EC232552   EC232973   EC233120   EC233378   EC234644   EC239640   EC240223   EC241625   EC241761   EC244189   EC244237   EC248723   EC249326   EC250156   EC250718   EC250924   EC251285   EC251513   EC251663   EC260409   GH965987   GH973801   GH982143   M21152 AAA28506   M21153
UniProtKB/Swiss-Prot	P16914
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References regulatory region FBsf0000161379 X:417,019..417,351 comment=region required for the neural specificity of elav expression in the embryonic nervous system evidence=experimental (Yao and White, 1994)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Campos et al., 1987) embryonic stage 11 -- 17     (Campos et al., 1987) Comment:reference states 6-18 hr AEL radioisotope in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11 -- 14   presumptive embryonic/larval central nervous system | presumptive   (Robinow and White, 1988) embryonic stage 11 -- 15   presumptive embryonic/larval nervous system   (Campos et al., 1987) Comment:reference states 6-12 hr AEL embryonic stage 13 -- 14   dorsal ectoderm | segmentally repeated   (Robinow and White, 1988) third instar larval stage   ventral nerve cord   (Robinow and White, 1988) morphogenetic furrow | posterior to   (Robinow and White, 1988) embryonic/larval brain   (Robinow and White, 1988) pharate adult stage P15   thoracico-abdominal ganglion   (Robinow and White, 1988) Comment:96 hr APF adult stage   Johnston organ   (Robinow and White, 1988)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11 -- 15   central nervous system   (Robinow and White, 1991) embryonic stage 11 -- 16   embryonic/larval nervous system   (Bier et al., 1988) embryonic stage 13 -- 15   peripheral nervous system   (Robinow and White, 1991) embryonic stage 14   neuron   • nucleus (Rao et al., 1991) embryonic stage 16   neuron   • nucleus (Orgogozo et al., 2004) larval stage -- prepupal stage   neuron & mushroom body   • nucleus (Watts et al., 2004) third instar larval stage   embryonic/larval brain   (Robinow and White, 1991) eye-antennal disc   (Robinow and White, 1991) morphogenetic furrow | posterior to   (Weng and Du, 2002) eye photoreceptor cell   (Weng and Du, 2002) third instar larval stage -- pharate adult stage P8   photoreceptor cell   (Domingos et al., 2004) Comment:until 48 hr APF prepupal stage P4(ii)   eye-antennal disc   (Robinow and White, 1991) Comment:reference states 12 hr APF prepupal stage P4(ii) -- pharate adult stage P8   ocellus | precursor   (Robinow and White, 1991) Comment:reference states 12-50 hr APF pupal stage -- adult stage   adult brain   (Robinow and White, 1991) pharate adult stage P9   eye   (Robinow and White, 1991) Comment:reference states 72 hr APF cortex of lamina   (Robinow and White, 1991) Comment:reference states 72 hr APF lobula plate cortex   (Robinow and White, 1991) Comment:reference states 72 hr APF cortex of medulla   (Robinow and White, 1991) Comment:reference states 72 hr APF lamina monopolar neuron   (Robinow and White, 1991) Comment:reference states 72 hr APF retina   (Robinow and White, 1991) Comment:reference states 72 hr APF thoracico-abdominal ganglion   (Robinow and White, 1991) Comment:72 hr APF adult stage   thoracico-abdominal ganglion   (Robinow and White, 1991) ocellus   (Robinow and White, 1991) retina   (Robinow and White, 1991) eye   (Robinow and White, 1991) antenna   (Robinow and White, 1991) photoreceptor cell R1 -- photoreceptor cell R8   (Robinow and White, 1991)
Additional Descriptive Data
	The elav protein, which contains RNA-binding motifs, is distributed non-uniformly in the nucleus, and may be part of a larger ribonucleoprotein complex. (Robinow and White, 1991) staining is first visible in the R8 cells immediately posterior to the morphogenetic furrow and continues as other photoreceptors are recruited into the cluster. (Weng and Du, 2002)
Marker for
	neuron differentiation neuron photoreceptor cell neuron
Subcellular Localization
CV Term	nucleus (Robinow and White, 1991)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0260400    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0260400 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0260400 expression level Developmental Stage   Expression Level embryo 00-02hr    59 embryo 02-04hr    647 embryo 04-06hr    1763 embryo 06-08hr    4344 embryo 08-10hr    5891 embryo 10-12hr    4889 embryo 12-14hr    4377 embryo 14-16hr    2404 embryo 16-18hr    1649 embryo 18-20hr    1212 embryo 20-22hr    759 embryo 22-24hr    856 larva L1    776 larva L2    472 larva L3 12hr old    375 larva L3 puffstage 1-2    145 larva L3 puffstage 3-6    653 larva L3 puffstage 7-9    808 white prepupae new    1055 white prepupae 12hr    1158 white prepupae 24hr    1532 pupae 2d postWPP    1034 pupae 3d postWPP    541 pupae 4d postWPP    248 adult male 01day    383 adult male 05day    377 adult male 30day    281 adult female 01day    191 adult female 05day    79 adult female 30day    75 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    59 embryo 02-04hr  (647) embryo 04-06hr  (1763) embryo 06-08hr  (4344) embryo 08-10hr  (5891) embryo 10-12hr  (4889) embryo 12-14hr  (4377) embryo 14-16hr  (2404) embryo 16-18hr  (1649) embryo 18-20hr  (1212) embryo 20-22hr  (759) embryo 22-24hr  (856) larva L1  (776) larva L2  (472) larva L3 12hr old  (375) larva L3 puffstage 1-2  (145) larva L3 puffstage 3-6  (653) larva L3 puffstage 7-9  (808) white prepupae new  (1055) white prepupae 12hr  (1158) white prepupae 24hr  (1532) pupae 2d postWPP  (1034) pupae 3d postWPP  (541) pupae 4d postWPP  (248) adult male 01day  (383) adult male 05day  (377) adult male 30day  (281) adult female 01day  (191) adult female 05day    79 adult female 30day    75 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    59 embryo 02-04hr    647 embryo 04-06hr  (1763) embryo 06-08hr  (4344) embryo 08-10hr  (5891) embryo 10-12hr  (4889) embryo 12-14hr  (4377) embryo 14-16hr  (2404) embryo 16-18hr  (1649) embryo 18-20hr    1212 embryo 20-22hr    759 embryo 22-24hr    856 larva L1    776 larva L2    472 larva L3 12hr old    375 larva L3 puffstage 1-2    145 larva L3 puffstage 3-6    653 larva L3 puffstage 7-9    808 white prepupae new    1055 white prepupae 12hr    1158 white prepupae 24hr  (1532) pupae 2d postWPP    1034 pupae 3d postWPP    541 pupae 4d postWPP    248 adult male 01day    383 adult male 05day    377 adult male 30day    281 adult female 01day    191 adult female 05day    79 adult female 30day    75 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    59 embryo 02-04hr    647 embryo 04-06hr    1763 embryo 06-08hr    4344 embryo 08-10hr    5891 embryo 10-12hr    4889 embryo 12-14hr    4377 embryo 14-16hr    2404 embryo 16-18hr    1649 embryo 18-20hr    1212 embryo 20-22hr    759 embryo 22-24hr    856 larva L1    776 larva L2    472 larva L3 12hr old    375 larva L3 puffstage 1-2    145 larva L3 puffstage 3-6    653 larva L3 puffstage 7-9    808 white prepupae new    1055 white prepupae 12hr    1158 white prepupae 24hr    1532 pupae 2d postWPP    1034 pupae 3d postWPP    541 pupae 4d postWPP    248 adult male 01day    383 adult male 05day    377 adult male 30day    281 adult female 01day    191 adult female 05day    79 adult female 30day    75 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    59 embryo 02-04hr    647 embryo 04-06hr    1763 embryo 06-08hr    4344 embryo 08-10hr    5891 embryo 10-12hr    4889 embryo 12-14hr    4377 embryo 14-16hr    2404 embryo 16-18hr    1649 embryo 18-20hr    1212 embryo 20-22hr    759 embryo 22-24hr    856 larva L1    776 larva L2    472 larva L3 12hr old    375 larva L3 puffstage 1-2    145 larva L3 puffstage 3-6    653 larva L3 puffstage 7-9    808 white prepupae new    1055 white prepupae 12hr    1158 white prepupae 24hr    1532 pupae 2d postWPP    1034 pupae 3d postWPP    541 pupae 4d postWPP    248 adult male 01day    383 adult male 05day    377 adult male 30day    281 adult female 01day    191 adult female 05day    79 adult female 30day    75 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0260400 expression level Developmental Stage   Expression Level embryo 00-02hr    59 embryo 02-04hr    647 embryo 04-06hr    1763 embryo 06-08hr    4344 embryo 08-10hr    5891 embryo 10-12hr    4889 embryo 12-14hr    4377 embryo 14-16hr    2404 embryo 16-18hr    1649 embryo 18-20hr    1212 embryo 20-22hr    759 embryo 22-24hr    856 larva L1    776 larva L2    472 larva L3 12hr old    375 larva L3 puffstage 1-2    145 larva L3 puffstage 3-6    653 larva L3 puffstage 7-9    808 white prepupae new    1055 white prepupae 12hr    1158 white prepupae 24hr    1532 pupae 2d postWPP    1034 pupae 3d postWPP    541 pupae 4d postWPP    248 adult male 01day    383 adult male 05day    377 adult male 30day    281 adult female 01day    191 adult female 05day    79 adult female 30day    75 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    59 embryo 02-04hr  (647) embryo 04-06hr  (1763) embryo 06-08hr  (4344) embryo 08-10hr  (5891) embryo 10-12hr  (4889) embryo 12-14hr  (4377) embryo 14-16hr  (2404) embryo 16-18hr  (1649) embryo 18-20hr  (1212) embryo 20-22hr  (759) embryo 22-24hr  (856) larva L1  (776) larva L2  (472) larva L3 12hr old  (375) larva L3 puffstage 1-2  (145) larva L3 puffstage 3-6  (653) larva L3 puffstage 7-9  (808) white prepupae new  (1055) white prepupae 12hr  (1158) white prepupae 24hr  (1532) pupae 2d postWPP  (1034) pupae 3d postWPP  (541) pupae 4d postWPP  (248) adult male 01day  (383) adult male 05day  (377) adult male 30day  (281) adult female 01day  (191) adult female 05day    79 adult female 30day    75 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    59 embryo 02-04hr    647 embryo 04-06hr  1763 embryo 06-08hr  (4344) embryo 08-10hr  (5891) embryo 10-12hr  (4889) embryo 12-14hr  (4377) embryo 14-16hr  2404 embryo 16-18hr  1649 embryo 18-20hr    1212 embryo 20-22hr    759 embryo 22-24hr    856 larva L1    776 larva L2    472 larva L3 12hr old    375 larva L3 puffstage 1-2    145 larva L3 puffstage 3-6    653 larva L3 puffstage 7-9    808 white prepupae new    1055 white prepupae 12hr    1158 white prepupae 24hr  1532 pupae 2d postWPP    1034 pupae 3d postWPP    541 pupae 4d postWPP    248 adult male 01day    383 adult male 05day    377 adult male 30day    281 adult female 01day    191 adult female 05day    79 adult female 30day    75 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    59 embryo 02-04hr    647 embryo 04-06hr    1763 embryo 06-08hr    4344 embryo 08-10hr    5891 embryo 10-12hr    4889 embryo 12-14hr    4377 embryo 14-16hr    2404 embryo 16-18hr    1649 embryo 18-20hr    1212 embryo 20-22hr    759 embryo 22-24hr    856 larva L1    776 larva L2    472 larva L3 12hr old    375 larva L3 puffstage 1-2    145 larva L3 puffstage 3-6    653 larva L3 puffstage 7-9    808 white prepupae new    1055 white prepupae 12hr    1158 white prepupae 24hr    1532 pupae 2d postWPP    1034 pupae 3d postWPP    541 pupae 4d postWPP    248 adult male 01day    383 adult male 05day    377 adult male 30day    281 adult female 01day    191 adult female 05day    79 adult female 30day    75 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    59 embryo 02-04hr    647 embryo 04-06hr    1763 embryo 06-08hr    4344 embryo 08-10hr    5891 embryo 10-12hr    4889 embryo 12-14hr    4377 embryo 14-16hr    2404 embryo 16-18hr    1649 embryo 18-20hr    1212 embryo 20-22hr    759 embryo 22-24hr    856 larva L1    776 larva L2    472 larva L3 12hr old    375 larva L3 puffstage 1-2    145 larva L3 puffstage 3-6    653 larva L3 puffstage 7-9    808 white prepupae new    1055 white prepupae 12hr    1158 white prepupae 24hr    1532 pupae 2d postWPP    1034 pupae 3d postWPP    541 pupae 4d postWPP    248 adult male 01day    383 adult male 05day    377 adult male 30day    281 adult female 01day    191 adult female 05day    79 adult female 30day    75 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0260400    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0260400 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult thoracico-abdominal ganglion. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0260400 expression level Tissue   Expression Level Larval Central Nervous System    524.525 Larval Midgut no informative data Larval Hindgut    27.5 Larval Malpighian Tubules no informative data Larval Fat Body    7.5 Larval Salivary Gland no informative data Larval Trachea    61.325 Larval Carcass no informative data Adult Head    72.3 Adult Eye    251.825 Adult Brain    816.6 Adult Thoracic-Abdominal Ganglion    394.2 Adult Crop    83.1 Adult Midgut no informative data Adult Hindgut    76.7 Adult Malpighian Tubules    33.8 Adult Fat Body    25.8 Adult Salivary Gland no informative data Adult Heart    59.875 Adult VirginFemale Spermatheca    29.5 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    6.5 Adult Testis    7 Adult Male Accessory Gland    26.1 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  524.525 Larval Midgut no informative data Larval Hindgut    27.5 Larval Malpighian Tubules no informative data Larval Fat Body    7.5 Larval Salivary Gland no informative data Larval Trachea    61.325 Larval Carcass no informative data Adult Head    72.3 Adult Eye    251.825 Adult Brain  (816.6) Adult Thoracic-Abdominal Ganglion    394.2 Adult Crop    83.1 Adult Midgut no informative data Adult Hindgut    76.7 Adult Malpighian Tubules    33.8 Adult Fat Body    25.8 Adult Salivary Gland no informative data Adult Heart    59.875 Adult VirginFemale Spermatheca    29.5 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    6.5 Adult Testis    7 Adult Male Accessory Gland    26.1 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    524.525 Larval Midgut no informative data Larval Hindgut    27.5 Larval Malpighian Tubules no informative data Larval Fat Body    7.5 Larval Salivary Gland no informative data Larval Trachea    61.325 Larval Carcass no informative data Adult Head    72.3 Adult Eye    251.825 Adult Brain    816.6 Adult Thoracic-Abdominal Ganglion    394.2 Adult Crop    83.1 Adult Midgut no informative data Adult Hindgut    76.7 Adult Malpighian Tubules    33.8 Adult Fat Body    25.8 Adult Salivary Gland no informative data Adult Heart    59.875 Adult VirginFemale Spermatheca    29.5 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    6.5 Adult Testis    7 Adult Male Accessory Gland    26.1 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    524.525 Larval Midgut no informative data Larval Hindgut    27.5 Larval Malpighian Tubules no informative data Larval Fat Body    7.5 Larval Salivary Gland no informative data Larval Trachea    61.325 Larval Carcass no informative data Adult Head    72.3 Adult Eye    251.825 Adult Brain    816.6 Adult Thoracic-Abdominal Ganglion    394.2 Adult Crop    83.1 Adult Midgut no informative data Adult Hindgut    76.7 Adult Malpighian Tubules    33.8 Adult Fat Body    25.8 Adult Salivary Gland no informative data Adult Heart    59.875 Adult VirginFemale Spermatheca    29.5 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    6.5 Adult Testis    7 Adult Male Accessory Gland    26.1 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0260400 expression level Tissue   Expression Level Larval Central Nervous System    524.525 Larval Midgut no informative data Larval Hindgut    27.5 Larval Malpighian Tubules no informative data Larval Fat Body    7.5 Larval Salivary Gland no informative data Larval Trachea    61.325 Larval Carcass no informative data Adult Head    72.3 Adult Eye    251.825 Adult Brain    816.6 Adult Thoracic-Abdominal Ganglion    394.2 Adult Crop    83.1 Adult Midgut no informative data Adult Hindgut    76.7 Adult Malpighian Tubules    33.8 Adult Fat Body    25.8 Adult Salivary Gland no informative data Adult Heart    59.875 Adult VirginFemale Spermatheca    29.5 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    6.5 Adult Testis    7 Adult Male Accessory Gland    26.1 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  524.525 Larval Midgut no informative data Larval Hindgut    27.5 Larval Malpighian Tubules no informative data Larval Fat Body    7.5 Larval Salivary Gland no informative data Larval Trachea    61.325 Larval Carcass no informative data Adult Head    72.3 Adult Eye    251.825 Adult Brain  (816.6) Adult Thoracic-Abdominal Ganglion    394.2 Adult Crop    83.1 Adult Midgut no informative data Adult Hindgut    76.7 Adult Malpighian Tubules    33.8 Adult Fat Body    25.8 Adult Salivary Gland no informative data Adult Heart    59.875 Adult VirginFemale Spermatheca    29.5 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    6.5 Adult Testis    7 Adult Male Accessory Gland    26.1 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    524.525 Larval Midgut no informative data Larval Hindgut    27.5 Larval Malpighian Tubules no informative data Larval Fat Body    7.5 Larval Salivary Gland no informative data Larval Trachea    61.325 Larval Carcass no informative data Adult Head    72.3 Adult Eye    251.825 Adult Brain    816.6 Adult Thoracic-Abdominal Ganglion    394.2 Adult Crop    83.1 Adult Midgut no informative data Adult Hindgut    76.7 Adult Malpighian Tubules    33.8 Adult Fat Body    25.8 Adult Salivary Gland no informative data Adult Heart    59.875 Adult VirginFemale Spermatheca    29.5 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    6.5 Adult Testis    7 Adult Male Accessory Gland    26.1 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    524.525 Larval Midgut no informative data Larval Hindgut    27.5 Larval Malpighian Tubules no informative data Larval Fat Body    7.5 Larval Salivary Gland no informative data Larval Trachea    61.325 Larval Carcass no informative data Adult Head    72.3 Adult Eye    251.825 Adult Brain    816.6 Adult Thoracic-Abdominal Ganglion    394.2 Adult Crop    83.1 Adult Midgut no informative data Adult Hindgut    76.7 Adult Malpighian Tubules    33.8 Adult Fat Body    25.8 Adult Salivary Gland no informative data Adult Heart    59.875 Adult VirginFemale Spermatheca    29.5 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    6.5 Adult Testis    7 Adult Male Accessory Gland    26.1 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules no informative data Larval Fat Body     Larval Salivary Gland no informative data Larval Trachea     Larval Carcass no informative data Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    72.3   NA  Eye    251.825   NA  Brain    816.6   524.525  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    394.2   NA  Crop    83.1   no informative data  Midgut    no informative data   27.5  Hindgut    76.7   no informative data  Malpighian Tubules    33.8   7.5  Fat Body    25.8   no informative data  Salivary Gland    no informative data   NA  Heart    59.875   61.325  Trachea    NA   NA  VirginFemale Spermatheca    29.5   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    6.5   NA  Testis    7   NA  Male Accessory Gland    26.1   no informative data  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_11
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0260400
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL429BD elavGS1091 lethal, with Scer\GAL4c355 elavGS1091 lethal, with Scer\GAL4dpp.blk1 elavGS1091 lethal, with Scer\GAL4elav.PLu elavGD5206 lethal, with Scer\GAL4hs.2sev elavGS1091 lethal | embryonic stage elav1 elav2 elav4 elavG0031 elavG0319 lethal | embryonic stage | recessive elav8 lethal | heat sensitive elavts1 lethal | heat sensitive (with elav5) elavts1 lethal | heat sensitive (with elavts1) elav5 lethal | recessive elav17 elav18 elavDmORF elavG0031 elavG0319 elavPG159 elavΔ5'int elavΔint semi-lethal, with Scer\GAL4Mef2.PR elavGD5206 viable elav5-45fD elav19.tSa elav20.t15.5 elav20.tSa elav336 elav+t13.5 elav+t15.5 elavts1.tSa elavts1 viable, with Scer\GAL4pnr-MD237 elavGD5206 Sterility Allele sterile | recessive elavDmORF elavΔ5'int elavΔint Other Phenotypes Allele behavior defective elav19 elavts1 behavior defective | heat sensitive elav19 elav20 elavts1 flight defective, with Scer\GAL4elav.PLu elavGD5206 flightless | heat sensitive elav19 elav20 elavts1 neuroanatomy defective elav5 elavE476 neuroanatomy defective | heat sensitive (with elav5) elavts1 neuroanatomy defective | heat sensitive (with elavts1) elav5 neurophysiology defective elav19 neurophysiology defective | heat sensitive elav19 uncoordinated | heat sensitive elav19 elav20 elavts1 visual behavior defective elav19 visual behavior defective | heat sensitive elav19 wild-type elav-13 elav339 elav+t8.5 elav+t13.5 elav+t15.5 elavDmORF elavedr elavΔ5'int elavΔint Phenotype manifest in Allele commissure elavE476 elavM454 elav5 EG neuron elavE476 elav5 EW neuron elavE476 elav5 eye elav5 elavedr eye | heat sensitive elavts1 eye | somatic clone elav4 medulla elavts1 midline glial cell elavM454 neuromuscular junction | heat sensitive (with elav5) elavts1 neuromuscular junction | heat sensitive (with elavts1) elav5 NMJ bouton | heat sensitive (with elav5) elavts1 NMJ bouton | heat sensitive (with elavts1) elav5 optic chiasm elavts1 optic lobe elav19 optic lobe | heat sensitive elav19 photoreceptor cell elav19 photoreceptor cell | heat sensitive elav19 elavts1 posterior commissure elavE476 elav5 retina elav5 elavedr rhabdomere elav19 serotonergic neuron SP2 elavE476 elav5 SP1 neuron elavE476 elav5 wing elav19 wing, with Scer\GAL4elav.PLu elavGD5206
Classical Alleles ( 39 )
For All Classical Alleles Show
Allele of elav Class Mutagen Stocks Known lesion elavC155 P-element activity 16 -- elav5-45fD 8 Yes elavG0378a P-element activity 3 -- elav4 X ray 2 Yes elavG0031 P-element activity 2 -- elavG0319 P-element activity 2 -- elavEY09088 P-element activity 1 -- elavf07906 1 -- elavNP7211 1 -- elav5 amorphic allele - genetic evidence, loss of function allele X ray 0 Yes elav10 ethyl methanesulfonate 0 -- elav11 ethyl methanesulfonate 0 -- elav12 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- elav13 ethyl nitrosourea 0 -- elav14 ethyl nitrosourea 0 -- elav15 ethyl nitrosourea 0 -- elav16 ethyl nitrosourea 0 -- elav17 hycanthon methanesulfonate 0 -- elav18 hycanthon methanesulfonate 0 -- elav19 ethyl methanesulfonate 0 Yes elav1 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- elav20 ethyl methanesulfonate 0 Yes elav2 methyl methanesulfonate 0 -- elav3 methyl methanesulfonate 0 -- elav5-HA-2732 0 -- elav6 X ray 0 -- elav7 X ray 0 -- elav8 ethyl methanesulfonate 0 -- elav95 Delta2-3 0 Yes elav9 ethyl methanesulfonate 0 -- elavE476 loss of function allele ethyl methanesulfonate 0 -- elavE P-element activity 0 Yes elavedr P-element activity 0 Yes elavFO FLPase 0 Yes elavGS1091 Delta2-3 0 Yes elavM454 ethyl methanesulfonate 0 -- elavPG159 Delta2-3 0 -- elavts1 ethyl methanesulfonate 0 Yes elavunspecified 0 --
Alleles Carried on Transgenic Constructs ( 36 )
For All Alleles Carried on Transgenic Constructs Show
Allele of elav Class Mutagen Stocks Known lesion elavGD5206 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes elavJF03008 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes elav+t13.5 in vitro construct - genomic fragment 0 Yes elav+t15.5 in vitro construct - genomic fragment 0 Yes elav+t8.5 in vitro construct - genomic fragment 0 Yes elav-13 in vitro construct - deletion 0 Yes elav19.tSa in vitro construct - regulatory fusion in vitro construct 0 Yes elav1AGD in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes elav20.t15.5 in vitro construct - genomic fragment 0 Yes elav20.tSa in vitro construct - regulatory fusion in vitro construct 0 Yes elav2AGD in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes elav336 in vitro construct 0 Yes elav339 in vitro construct 0 Yes elav3AGD in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes elavDmORF-120 in vitro construct - deletion 0 Yes elavDmORF in vitro construct - regulatory fusion in vitro construct - genomic fragment in vitro construct 0 Yes elavdsRNA.cJa in vitro construct - RNAi 0 Yes elavh.Scer\UAS.T:Avic\GFP-S65T in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes elavh.T:Avic\GFP-S65T in vitro construct - coding region fusion 0 Yes elavhRRM3.Scer\UAS.T:Avic\GFP-S65T in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes elavhs.PL in vitro construct - regulatory fusion 0 Yes elavRBD in vitro construct - deletion 0 Yes elavScer\UAS.cFa 0 Yes elavScer\UAS.cKa in vitro construct - regulatory fusion 0 Yes elavT:Avic\GFP-S65T in vitro construct - coding region fusion 0 Yes elavts1.tSa in vitro construct - regulatory fusion in vitro construct 0 Yes elavΔ5'int in vitro construct - genomic fragment 0 Yes elavΔCh.T:PV\nls4 in vitro construct - coding region fusion 0 Yes elavΔCh in vitro construct - deletion 0 Yes elavΔEh.T:PV\nls4 in vitro construct - coding region fusion 0 Yes elavΔEh in vitro construct - deletion 0 Yes elavΔint in vitro construct - genomic fragment 0 Yes elavΔNh.T:PV\nls4 in vitro construct - coding region fusion 0 Yes elavΔNh in vitro construct - deletion 0 Yes elavΔOh.T:PV\nls4 in vitro construct - coding region fusion 0 Yes elavΔOh in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(1)260-1 (White et al., 1983) Df(1)403 (Kramers et al., 1991) Df(1)A94 (Kramers et al., 1991) Df(1)cin-arth (Kramers et al., 1983, Kramers et al., 1991) Df(1)HA18 (Schalet, 1986) Df(1)S39 (Kramers et al., 1991) Df(1)sc8 (White et al., 1983) Df(1)Sp(br-dor) (Schalet, 1986) Df(1)Sp(J1a) (Schalet, 1986) Df(1)Sp(J1b) (Schalet, 1986) Df(1)Sp(J1c) (Schalet, 1986) Df(1)sta (Kramers et al., 1991) Df(1)vndD38 (Chu et al., 1998) Df(1)yT4-8 (Sherald and Voelker, 1985) Df(1)yT4-19 (White et al., 1983, Homyk and Pye, 1989) Df(1)yT4-20 (Sherald and Voelker, 1985) Df(1)yT6-450 (Campos et al., 1987) Df(1)yT6-506 (Campos et al., 1987)
Disrupted in	Df(1)74 (White et al., 1983) Df(1)Exel6221 (Ryder, 2004.4.26) Df(1)svr (Kramers et al., 1983, Corbin et al., 1991, Kramers et al., 1991, Bate et al., 1993) Df(1)y74k24.1 (Kramers et al., 1983, Kramers et al., 1991) Df(1)yT6-437 (Campos et al., 1987, Luo et al., 1992) Df(1)yT7-178 (Rosen et al., 1989) Df(1)yT7-191 (Campos et al., 1987) Df(1)yT7-263 (Campos et al., 1987) Df(1)yT7-518 (Luo et al., 1992) In(1)elav4 (Samson, 2000, Campos et al., 1987)
Duplicated in	Dp(1;Y)59k9-4 (Kramers et al., 1983, Kramers et al., 1991) Dp(1;Y)y261l (White et al., 1983) Dp(1;Y)y267g19.1 (Lefevre, 1981, Schalet, 1986) Dp(1;Y)y+m64 (Luo et al., 1992) Dp(1;Y)y+sc (White et al., 1983)
Not duplicated in	Dp(1;3)sta (Kramers et al., 1991) Dp(1;f)24 (White et al., 1983)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5206} NA P{TRiP.JF03008} NA P{UAS-elav.F} NA P{UAS-elav.h.GFP} NA P{UAS-elav.hRRM3.GFP} NA P{UAS-elav} NA reporter construct P{elav-lacZ.1} No P{elav-lacZ.2} No P{elav-lacZ.A} No P{elav-lacZ.B} No P{elav-lacZ.C} No P{elav-lacZ.D} No P{elav-lacZ.E} No P{elav-lacZ.F} No P{elav-lacZ.H} No P{elav-lacZ.Hb} No P{elav-lacZ.I} No P{elav-lacZ.J} No P{elav-lacZ.K} No P{elav-lacZ.L} No P{elav-lacZ.W} No heat-shock construct P{hs-elav.L} NA characterization construct P{336} NA P{339} NA P{elav13.5} NA P{elav::Hsap\ELAVL4EH3} NA P{elav::Rbp9ER1} NA P{elav::Rbp9ER3} NA P{elav::Rbp9ER12} NA P{elav::SxlES1.2} NA P{elav::SxlES1} NA P{elav::SxlES2} NA P{elav::SxlES12} NA P{elav1AGD} NA P{elav2AGD} NA P{elav3AGD} NA P{elav-13} NA P{elav20.t15.5} NA P{elav+t15.5} NA P{elavh.T:Avic\GFP-S65T} NA P{elavT:Avic\GFP-S65T} NA P{elavΔ5'int} NA P{elavΔCh.T:PV\nls4} NA P{elavΔCh} NA P{elavΔEh.T:PV\nls4} NA P{elavΔEh} NA P{elavΔint} NA P{elavΔNh.T:PV\nls4} NA P{elavΔNh} NA P{elavΔOh.T:PV\nls4} NA P{elavΔOh} NA P{elavDmORF-120} NA P{elavDmORF} NA P{elavDvORF} NA P{elav-NRF-1.H} NA P{elav-p35.B} NA P{FliJ1} NA P{FliJ2} NA P{minigene8.5} NA P{RBD} NA P{TS1} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}argEP452 NA P{EP}argEP1117 NA P{EPgy2}elavEY09088 NA P{GSV1}elavGS1091 NA P{Mae-UAS.6.11}B2001B2001 NA P{Mae-UAS.6.11}B2002B2002 NA P{Mae-UAS.6.11}B2003B2003 NA P{Mae-UAS.6.11}GG01017GG01017 NA P{XP}argd04008 NA P{XP}argd04598 NA P{XP}argd06892 NA miscellaneous insertions P{elavDmORF}elavedr NA P{ftz/lacF}6727 NA P{PT1}elav95 NA P{PT1Δ}elavFO NA P{RS5}elav5-HA-2732 NA PBac{RB}arge02444 NA PBac{RB}arge04578 NA PBac{WH}elavf07906 NA insertion of enhancer trap binary system P{GawB}elavC155 No P{GawB}elavNP7211 No P{GawB}elavPG159 No insertion of enhancer trap P{lacW}elav5-45fD No P{lacW}elavE No P{lacW}elavG0031 No P{lacW}elavG0319 No P{lacW}elavG0378a No
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function
CV term Evidence References
poly(U) RNA binding inferred from direct assay (Samson and Chalvet, 2003) RNA binding inferred from direct assay (Soller and White, 2003)
Biological Process
CV term Evidence References
central nervous system development inferred from mutant phenotype (Hummel et al., 1999) negative regulation of mRNA 3'-end processing inferred from direct assay (Soller and White, 2003)
Cellular Component
CV term Evidence References
Cajal body inferred from direct assay (Yannoni and White, 1997) nucleus inferred from direct assay (Robinow and White, 1991, Yannoni and White, 1997, Samson and Chalvet, 2003)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
mRNA binding inferred from sequence or structural similarity (Lasko, 2000) non-traceable author statement (Swiss-Prot Project Members, 1990.8.1, Good, 1997) nucleotide binding inferred from electronic annotation with InterPro:IPR012677 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
nervous system development non-traceable author statement (Swiss-Prot Project Members, 1990.8.1, Good, 1997) RNA metabolic process non-traceable author statement (Swiss-Prot Project Members, 1990.8.1)
Cellular Component
CV term Evidence References
nucleus traceable author statement (Good, 1997)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions elav allele Gene References unspecified aos (Sawamoto et al., 1996)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 57569 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0260400 DroID - A comprehensive database of gene and protein interactions. • FBgn0260400 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31000
Orthologs
Genome-wide drosophilid orthologs	Dana\GF22224 Dere\GG12756 Dgri\GH12602 Dmoj\GI15436 Dper\GL20165 Dpse\GA18065 Dsec\GM19036 Dsim\GD16475 Dvir\elav Dwil\GK16120 Dyak\GE16581
Curated drosophilid orthologs	Dame\elav (Maside et al., 2004) Damx\elav (Maside and Charlesworth, 2007) Dezo\elav (Maside and Charlesworth, 2007) Dlit\elav (Maside and Charlesworth, 2007) Dmir\elav   Dmon\elav (Vieira et al., 2004.12.17) Dpse\GA18065   Dvir\elav
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL008164-PA Aedes aegypti (mosquito) CPIJ008385 Culex pipens (mosquito) 99329 Chlamidomonas reinhardtii (green alga)
Stocks & Reagents
Stocks Listed in FlyBase ( 38 )
Bloomington	458 P{GawB}elavC155 33805 P{GawB}elavC155; P{EP}DnaJ-1EP411 6923 P{GawB}elavC155, P{UAS-syt.eGFP}1, w* 25750 P{GawB}elavC155 w1118; P{UAS-Dcr-2.D}2 6920 P{GawB}elavC155, P{UAS-n-syb.eGFP}1, w*/FM7a 28371 y1 v1; P{TRiP.JF03008}attP2/TM3, Sb1 12098 P{lacW}elavG0031 argG0031 w67c23/FM7c 12240 P{lacW}elavG0319 argG0319 w67c23/FM7c
Harvard	- PBac{WH}elavf07906
Kyoto	105921 P{GawB}elavC155 114148 P{GawB}elavNP7211 w* / FM7c
VDRC	v37915 w1118; P{GD5206}v37915
	More stocks available...
Genomic Clones ( 2 )
	BACR08O05 BACR16G06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 142 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD33076
Other clones	DPiM_LD33076 RE14370
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	HL03451 LD08492 LD31344 LD39646 LD44587 LP16861 RE37058 RE58603
Other clones	9872 11972 12164 15813 17112 28640 28655 28706 29697 30787 33154 33185 37347.1 44278 57472 61002 61976 65390 67694 72416 77281 97405 105865 117823 119734 119888 145170 147188 157147 157960 162354 162578 166293 167160 172598 172830 175902 175996 178111 191274 194920 194922 273362 277457 282159 283636 CK01.1C.C11 CK01.2C.G6 CK01.10C.H12 CK01.15D.D8 CK01.16B.H6 CK01.68D.E10 CK01.75C.G4 CK01.76A.F3 CK01.76D.E2 CK01.76D.H2 CK01.80A.G1 CK01.81C.D6 CK01.96D.E6 CK01.104B.C10 CK01.104D.A12 CK01.116C.D2 CK01.116C.E6 CK01.128B.F11 CK01.129B.H7 CK01.141C.B8 CK01.142D.H6 EC251513 EC251663 EK005151 EK007145 EK010015 EK015848 EK039518 EK059158 EK059422 EK060049 EK060061 EK062025 EK064247 EK074602 EK075151 EK082150 EK095732 EK107902 EK108502 EK112913 EK112916 EK116063 EK117940 EK118403 EK128533 EK136154 EK138320 EK142852 EK155855 EK159563 EK165760 EK165853 EK185514 EK185724 EK188603 EK195616 EK200725 EK231463 EK239630 EK239718 EK250414 EK252833 EK260923 EK261018 EK266133 EK270913 EK271707 EK272625 EK273407 EK277137 EK277310 EK293818 EK304812 EK307008 EK307528 EK308950 EP06034 EP09334 EP12158 EP13002 FGM318C04 RP004224779 RP004375739 RP004484421
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0260400 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31000 252541
Antibody Information
	monoclonal (Bier et al., 1988) monoclonal antibody (Domingos et al., 2004) polyclonal (Robinow and White, 1991)
Other Information
Discoverer
Etymology
	"weniger" means "less" in German. (Hummel et al., 1999)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: elav CG4262 (Nusskern, 1999.11)
Source for database merge of	Source for merge of: elav weg (Simionato et al., 2007)
Additional comments
Other Comments
	elav may increase splicing efficiency of ewg transcripts in alternatively spliced regions. (Koushika et al., 2000) Four EMS induced alleles were identified in a screen for mutations affecting commissure formation in the CNS of the embryo. (Hummel et al., 1999) Amino acid residues 333 to 374 in the hinge region of elav are necessary for nuclear localisation. (Yannoni and White, 1999) elav regulates neural expression of Nrg by promoting the formation of the neural-specific alternative splice variant of Nrg. (Koushika et al., 1996) elav 3' UTR is essential for normal elav expression. (Samson, 1995) Two distinct temperature-sensitive alleles of elav are suppressed nonsense mutations of the same tryptophan codon. (Samson et al., 1995) A sequence comparison and numerical analysis of the RRM-containing (RNA recognition motif) proteins suggests that functionally related RRM-containing proteins have significant sequence similarities in their RRMs. (Kim and Baker, 1993) RNA binding domain of elav is similar to that of cpo. (Bellen et al., 1992) Embryonic lethal, or in the case of viable and ostensibly hypomorphic alleles, displays poor jumping and flying ability plus aberrant visual physiology and behavior. No morphological abnormalities visible in sections of dying embryos (elav1, elav2, or elav3). elavts1 allows survival to adult stage at 19oC-25oC but viability is reduced and adults usually die soon after eclosion; viability after rearing at 30oC is very low and newly emerged adults show poor coordination and die soon; this temperature-sensitive allele also causes morphological abnormalities in the brain, especially in the visual system (after postembryonic shift from 19oC to 30oC or even following all development at low-temperature). In studies of viable alleles, elav19 and elav20, both of which are temperature-sensitive, flying and jumping ability shown to be especially aberrant after rearing at 29oC; wing position also aberrant; elavts1 most severe, including having no optomotor response when raised at high (or even low) temperature. (Lindsley and Zimm, 1992) The divergence of the gene sequences in the amino terminal region reflects lowered functional constraint, rather than species-specific functional specification. (Yao and White, 1991) Dvir\elav can substitute for elav in functional tests. (Yao and White, 1991) The presence of ena mutations does not compensate for the lethal effects of mutations in elav or vnd, genes important for neural development. (Gertler et al., 1990) Mutations of elav cause abnormalities in the electroretinogram (ERG) and/or prolonged depolarization after potential (PDA). (Homyk and Pye, 1989) RNA localisation studies demonstrate that the elav gene product provides a function which is required for the proper development and maintenance of all neurons. (Robinow and White, 1988) Whole-mount embryos show periodic interruptions in the longitudinal connectives of the CNS and missing commissures especially the posterior ones. (Jimenez and Campos-Ortega, 1987) Mosaic analysis of elav1 suggests both directly induced defects in optic lobe development, as well as inductively caused CNS defects mediated through expression of this mutation in the eye (i. e., such that the visual system's ganglia are genotypically normal). Lethal "focusing" in elav1 mosaics suggests influence of gene on derivatives of ventral blastoderm. (Campos et al., 1985) elav gene function is autonomously essential in the eye, is essential for normal development of the optic lobes and not necessary in most major imaginal disc cell derivatives with the exception of the eye disc. (Campos et al., 1985) Temperature-sensitive period for aberrant wing posture in elav19 extends from larval to pupal period. (Homyk and Grigliatti, 1983)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080294 NM_001014713 NM_001144670 RefSeq (Proteins) • NP_525033 NP_001014713 NP_001138142 DDBJ / EMBL / GenBank • AA697915 AA978889 AAA28506 AAF45517 AAF45517.2 AAK93246 AAX52472 ACL82875 AF047180 AL022139 AY051822 CAA18091 CAB37430 CL528154 DQ004736 DQ243913 DQ243914 M21152 M21153 Entrez Gene - A searchable database of RefSeq genes. • 31000 UniProtKB/Swiss-Prot • P16914
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • RNA recognition motif domain (IPR000504) Paraneoplastic encephalomyelitis antigen (IPR002343) Splicing factor ELAV/HuD (IPR006548) Nucleotide-binding, alpha-beta plait (IPR012677)
Linkouts
	BioGRID - A database of protein and genetic interactions • 57569 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0260400 DroID - A comprehensive database of gene and protein interactions. • FBgn0260400 DRSC - Results from RNAi screens. • FBgn0260400 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0260400 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0260400 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31000 252541 InParanoid A subset of ortholog calls from InParanoid. • AAEL008164-PA Aedes aegypti (mosquito) CPIJ008385 Culex pipens (mosquito) 99329 Chlamidomonas reinhardtii (green alga) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /neural/elav.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31000 modMine - Data generated by the modENCODE project. • FBgn0260400 REDfly - A database of transcriptional regulatory elements. • FBgn0260400
Synonyms & Secondary IDs ( 26 )
Reported As
Symbol Synonym	9F8A9 (Cyran et al., 2003) 44C11   CG4262 (Bourbon et al., 2002, Benos, 2000.12.13, Dallman et al., 2004, Grieder et al., 2007, Perkins et al., 2009, Ling and Salvaterra, 2011) EC7 (Kramers et al., 1991, Schalet, 1986, Lefevre and Watkins, 1986, Kramers et al., 1983, White et al., 1983, Lefevre, 1981) EG:65F1.2 (Benos et al., 2001, Benos, 2000.12.13, ) Elav (Python and Stocker, 2002, Jang et al., 2008, Wang et al., 2009, Cordero and Cagan, 2010, Mummery-Widmer et al., 2009, Tiwari and Roy, 2009, Giagtzoglou et al., 2009, Song and Taylor, 2003, Miller et al., 2009, Mirkovic et al., 2011, Benchabane et al., 2011, Benchabane et al., 2011, Hakeda-Suzuki et al., 2011, Li et al., 2006, Wang et al., 2005, Bray et al., 2005, Campuzano, 2001, Chen et al., 2003, Cooper, 2000, Goulding et al., 2000, Ekas et al., 2006, Singh et al., 2006, Zhang et al., 2005, Long et al., 2006, Pepple et al., 2007, Vrailas et al., 2006, Mao et al., 2006, Bello et al., 2006, Lim and Tomlinson, 2006, Roignant et al., 2006, Umetsu et al., 2006, Chotard et al., 2005, Li and Baker, 2004, Maitra et al., 2006, Rogers et al., 2005, Altenhein et al., 2006, Komiyama et al., 2004, Baril and Therrien, 2006, Mirkovic and Mlodzik, 2006, Takaesu et al., 2006, Zeitler et al., 2004, Kim et al., 2006, Ebacher et al., 2007, Pfleger et al., 2007, Merianda et al., 2005, Kracklauer et al., 2007, Wang et al., 2006, Sarkar et al., 2006, Bras-Pereira et al., 2006, Sprecher et al., 2007, Girard et al., 2006, Brown et al., 2006, Nishimura et al., 2007, Lee et al., 2006, Grillenzoni et al., 2007, Uhlirova and Bohmann, 2006, Lee et al., 2007, Silva, 2006, Wang et al., 2007, Bello et al., 2007, Coulom and Birman, 2004, Lichtneckert et al., 2007, Secombe et al., 2007, Hagedorn et al., 2006, Vrailas and Moses, 2006, Jafar-Nejad et al., 2005, Grieder et al., 2007, Zhu et al., 2008, Lim et al., 2005, Cope et al., 2002, Luque and Milan, 2007, Rawls et al., 2007, Menut et al., 2007, Bolkan et al., 2007, Mendes et al., 2006, Cayirlioglu et al., 2008, Eun et al., 2008, Fanto et al., 2003, Lee et al., 2006, Gallagher and Knoblich, 2006, del Alamo and Mlodzik, 2006, Buttitta et al., 2007, Escudero et al., 2007, Schuldiner et al., 2008, Bowman et al., 2008, Wilkin et al., 2008, Zhang et al., 2006, Xie et al., 2007, Lee et al., 2008, Miller et al., 2008, Benchabane et al., 2008, Yasugi et al., 2008, Miura et al., 2008, Lichtneckert et al., 2008, Hayashi et al., 2008, del Alamo and Mlodzik, 2008, Wheeler et al., 2008, Pepple et al., 2008, Ratnaparkhi and Zinn, 2007, Tsai et al., 2007, Casas-Tinto et al., 2008, Weber et al., 2008, Banerjee et al., 2008, Morey et al., 2003, Rimkus et al., 2008, Bayraktar et al., 2006, Firth and Baker, 2009, Guenin et al., 2006, Curtiss et al., 2007, McGraw et al., 2008, Edwards and Meinertzhagen, 2009, Almudi et al., 2009, Tseng et al., 2007, Bennett et al., 2008, Boone and Doe, 2008, McKay et al., 2009, Mao and Freeman, 2009, Sprecher and Desplan, 2008, Orgogozo and Grueber, 2005, Wang et al., 2008, Carrera et al., 2008, Huang et al., 2007, Yoshioka et al., 2007, Lin et al., 2008, Matsuno et al., 2007, Karsten et al., 2006, Dienstbier et al., 2009, Lee et al., 2009, Andrews et al., 2009, Alone et al., 2005, Lee et al., 2006, Glavic et al., 2009, Peng et al., 2009, Dziedzic et al., 2009, Courbard et al., 2009, O'Keefe et al., 2009, Bhattacharya and Baker, 2009, Baker et al., 2009, Li et al., 2009, Kamikouchi et al., 2006, Moyer and Jacobs, 2008, Kandachar et al., 2008, Martin et al., 2009, Ly et al., 2008, Remaud et al., 2008, Steele et al., 2009, Kumar et al., 2009, Morey et al., 2008, Tanaka-Matakatsu et al., 2007, Ambrus et al., 2009, Zhang et al., 2009, Izergina et al., 2009, Baonza and Freeman, 2005, Pérez et al., 2010, Fan et al., 2003, Mao et al., 2008, Chung et al., 2009, Kuniyoshi et al., 2003, Firth and Baker, 2007, Nishimura et al., 2008, Papadopoulos et al., 2010, Soustelle and Giangrande, 2007, Siegrist et al., 2010, Swanson et al., 2010, Wu et al., 2008, Siddall et al., 2009, Wu et al., 2009, Chen et al., 2009, Wu et al., 2008, zur Lage and Jarman, 2010, Salzer et al., 2010, Repnikova et al., 2010, Ghosh et al., 2010, Brankatschk and Eaton, 2010, Roignant and Treisman, 2010, Xiong et al., 2010, Song et al., 2010, Michaud and Tanguay, 2003, Tsuda et al., 2010, Watson et al., 2008, Nicholson et al., 2011, Wang et al., 2011, Morante et al., 2011, Ling and Salvaterra, 2011, Cho and Fischer, 2011, Kitajima et al., 2010, Awasaki et al., 2006, Tan et al., 2011, Mirkovic et al., 2011, Rebeiz et al., 2011, Brockmann et al., 2011, Kuzina et al., 2011, Benhra et al., 2011, Sousa-Nunes et al., 2011, Jiang et al., 2011, Jiang et al., 2011, Charlton-Perkins et al., 2011, Feng et al., 2011, Neumüller et al., 2011, Jacobsson et al., 2009, Houalla et al., 2010, Vrailas-Mortimer et al., 2011, Yamasaki et al., 2011, Vallejo et al., 2011) ElaV (Lai and Lee, 2006, Cordero and Cagan, 2010, Wernet et al., 2003, Takacs et al., 2008, Yogev et al., 2008) elav (Roignant et al., 2010, Menzel et al., 2007, Ben Rokia-Mille et al., 2008, Tamura et al., 2010, Richards et al., 2011, Simionato et al., 2007, Soller and White, 2005, Borgeson and Samson, 2005, Mills et al., 2006, Jemc and Rebay, 2006, Jones et al., 2006, Wehn and Campbell, 2006, Prakash et al., 2005, Collins et al., 2006, Choe et al., 2006, Rodrigues et al., 2005, Li and Carthew, 2005, Deschenes-Furry, 2006, Dickman, 2006, Wheeler et al., 2006, Herz et al., 2006, Acar et al., 2006, Kent et al., 2006, Shigenobu et al., 2006, Bartolome and Charlesworth, 2006, Charroux et al., 2006, Wang et al., 2006, Slepko et al., 2006, Husain et al., 2006, Lei et al., 2003, Mehta, 2005, Ayyub et al., 2005, Larsen et al., 2006, Yapici et al., 2008, Sugimura et al., 2004, Curtin et al., 2005, Muhlig-Versen et al., 2005, Grieder et al., 2007, Dietzl et al., 2007, Harrisingh et al., 2007, Mondal et al., 2007, Ice et al., 2005, Mondal et al., 2007, Berger et al., 2007, Li et al., 2008, Tien et al., 2008, Weasner et al., 2007, Mandalaywala et al., 2008, Cornbrooks et al., 2007, Font-Burgada et al., 2008, Thomsen et al., 2010, Aigouy et al., 2008, Duong et al., 2008, Lee et al., 2009, Salzer and Kumar, 2009, Benton et al., 2009, Wheeler et al., 2009, Toba and White, 2008, Yang et al., 2009, Häsemeyer et al., 2009, Read et al., 2009, Tamura et al., 2009, Peabody et al., 2009, Stagg et al., 2011, Choi et al., 2009, Pentek et al., 2009, Kim et al., 2007, Larsen et al., 2009, Sanyal, 2009, Bier et al., 1989, de Velasco et al., 2007, Diao et al., 2009, Younossi-Hartenstein et al., 2006, Shafer et al., 2006, Fung et al., 2008, Meier et al., 2006, Prakash et al., 2009, Udolph et al., 2009, Brás-Pereira and Casares, 2008, Belay et al., 2007, Zhou et al., 2009, Haussmann et al., 2008, Samson, 2008, Kondo et al., 2006, Wong et al., 2009, Fernández-Ayala et al., 2010, Bhuin and Roy, 2009, Xu et al., 2008, Fraichard et al., 2010, Rendic et al., 2010, Lorbeck et al., 2010, Kim et al., 2010, Chen et al., 2011, Liu et al., 2008, Samson and Chalvet, 2003, Jinushi-Nakao et al., 2007, Zeng et al., 2010, Chang et al., 2011, Yu et al., 2011, Wang et al., 2011, Nishimura et al., 2008, Hasegawa et al., 2011, Viktorin et al., 2011) ELAV (Fan et al., 2005, Hartmann et al., 2000, Hirth and Reichert, 1999, Buckles et al., 1992, Jafar-Nejad et al., 2006, Liao et al., 2006, Wang, 2007, Dallman et al., 2004, O'Farrell et al., 2008, Vanzo et al., 2007, Sprecher et al., 2006, Anderson et al., 2006, Iwanami et al., 2005, Bose et al., 2006, Acar et al., 2008, Cyran et al., 2005, Roegiers et al., 2005, Soller and White, 2003, Harris and Beckendorf, 2007, Mandal et al., 2005, Kurant et al., 2008, Beaucher et al., 2007, Fan and Bergmann, 2008, Tyler and Baker, 2007, Coiffier et al., 2008, Pierce et al., 2008, Rezával et al., 2008, Pellock et al., 2007, Fujii et al., 2008, Braid and Verheyen, 2008, Melicharek et al., 2008, Erclik et al., 2008, Erclik et al., 2008, Kato et al., 2009, Pickup et al., 2009, Yang and Baker, 2006, Bury et al., 2008, Venkatachalam et al., 2008, Loo et al., 2005, Rajan et al., 2009, O'Farrell and Kylsten, 2008, Willecke et al., 2006, Loewer et al., 2004, Shafer and Taghert, 2009, Sharma and Nirenberg, 2007, Simon et al., 2009, Berger et al., 2010, Lopes and Casares, 2010, Salzer and Kumar, 2010, Robinett et al., 2010, Kaneko et al., 1997, Lee et al., 2008, Ashton-Beaucage et al., 2010, Soller et al., 2010, Fiehler and Wolff, 2008, Spokony and Restifo, 2009, Albornoz et al., 2008, Colonques et al., 2011, Tan et al., 2011, Sprecher and Hirth, 2006, Fan et al., 2010) elav-1 (Kim and Baker, 1993) elav-2 (Kim and Baker, 1993) elav-3 (Kim and Baker, 1993) Elav-9F8A9 (Igaki et al., 2002) fliJ   l(1)1Be (The Moscow Regional Drosophila melanogaster Stock Center, Dubna, ) l(1)EC7 (Sherald and Voelker, 1985, ) l(1)G0031 (Schaefer et al., 1999.12.2, ) l(1)G0319 (Schaefer et al., 1999.12.2, ) weg
Name Synonym	Elav (Tsuda et al., 2006, Deb et al., 2008) embryonic lethal, abnormal vision (Wheeler et al., 2006, Harrisingh et al., 2007, Mondal et al., 2007, Berger et al., 2007) Embryonic lethal abnormal vision (Song and Taylor, 2003, Ling and Salvaterra, 2011) embryonic lethal abnormal vision (Mills et al., 2006, Muhlig-Versen et al., 2005, Simionato et al., 2007) Embryonic Lethal Abnormal Vision (Wang et al., 2007, Cyran et al., 2005, Fan et al., 2010) embryonic lethal abnormal visual system (Borgeson and Samson, 2005, Soller and White, 2003, Samson, 2008, Liu et al., 2008) Embryonic lethal abnormal visual system (Papadopoulos et al., 2010, Spokony and Restifo, 2009) weniger (Hummel et al., 1999)
Secondary FlyBase IDs
	FBgn0000570 FBgn0026157 FBgn0040177 FBgn0040203
References ( 962 )
Generate a list of	All references relating to this gene ( 962 )
List References by type	Research paper  ( 852 ) Supplementary material  ( 18 ) Review  ( 32 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 36 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) Curated genome annotation  ( 2 ) Book  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 3 ) DNA/RNA sequence record  ( 1 ) Null type  ( 1 ) Conference report  ( 1 ) Letter  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 64 )
	Benchabane et al., 2011, EMBO J. 30(8): 1444--1458 Jerky/Earthbound facilitates cell-specific Wnt/Wingless signalling by modulating β-catenin-TCF activity. [FBrf0213544] Benhra et al., 2011, Curr. Biol. 21(1): 87--95 AP-1 Controls the Trafficking of Notch and Sanpodo toward E-Cadherin Junctions in Sensory Organ Precursors. [FBrf0212697] Brockmann et al., 2011, Dev. Dyn. 240(1): 75--85 Regulation of ocellar specification and size by twin of eyeless and homothorax. [FBrf0212641] Chang et al., 2011, PLoS Genet. 7(2): e1001288 Pathogenic VCP/TER94 Alleles Are Dominant Actives and Contribute to Neurodegeneration by Altering Cellular ATP Level in a Drosophila IBMPFD Model. [FBrf0213008] Charlton-Perkins et al., 2011, Neural Dev. 6: 20 Prospero and Pax2 combinatorially control neural cell fate decisions by modulating Ras- and Notch-dependent signaling. [FBrf0213993] Chen et al., 2011, PLoS ONE 6(1): e16127 Genetic interaction of centrosomin and bazooka in apical domain regulation in Drosophila photoreceptor. [FBrf0212822] Cho and Fischer, 2011, Development 138(7): 1349--1359 Ral GTPase promotes asymmetric Notch activation in the Drosophila eye in response to Frizzled/PCP signaling by repressing ligand-independent receptor activation. [FBrf0213208] Colonques et al., 2011, PLoS ONE 6(4): e19342 A Transient Expression of Prospero Promotes Cell Cycle Exit of Drosophila Postembryonic Neurons through the Regulation of Dacapo. [FBrf0213608] Feng et al., 2011, EMBO Rep. 12(2): 157--163 Loss of the Polycomb group gene polyhomeotic induces non-autonomous cell overproliferation. [FBrf0214189] Goda et al., 2011, PLoS Genet. 7(7): e1002167 Adult Circadian Behavior in Drosophila Requires Developmental Expression of cycle, But Not period. [FBrf0214302] Hakeda-Suzuki et al., 2011, Nat. Neurosci. 14(3): 314--323 Golden Goal collaborates with Flamingo in conferring synaptic-layer specificity in the visual system. [FBrf0213128] Hasegawa et al., 2011, Development 138(5): 983--993 Concentric zones, cell migration and neuronal circuits in the Drosophila visual center. [FBrf0213020] Jiang et al., 2011, Oncogene 30(29): 3248--3260 Sds22/PP1 links epithelial integrity and tumor suppression via regulation of myosin II and JNK signaling. [FBrf0214488] Kuzina et al., 2011, Development 138(9): 1839--1849 How Notch establishes longitudinal axon connections between successive segments of the Drosophila CNS. [FBrf0213493] Ling and Salvaterra, 2011, PLoS ONE 6(3): e17762 Robust RT-qPCR Data Normalization: Validation and Selection of Internal Reference Genes during Post-Experimental Data Analysis. [FBrf0213272] Mirkovic et al., 2011, Nat. Struct. Mol. Biol. 18(6): 665--672 Nemo kinase phosphorylates β-catenin to promote ommatidial rotation and connects core PCP factors to E-cadherin-β-catenin. [FBrf0213849] Morante et al., 2011, Development 138(4): 687--693 Cell migration in Drosophila optic lobe neurons is controlled by eyeless/Pax6. [FBrf0212874] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Nicholson et al., 2011, Development 138(2): 251--260 Notch-dependent expression of the archipelago ubiquitin ligase subunit in the Drosophila eye. [FBrf0212669] Podratz et al., 2011, Neurobiol. Disease 43(2): 330--337 Drosophila melanogaster: A new model to study cisplatin-induced neurotoxicity. [FBrf0213891] Rebeiz et al., 2011, Development 138(2): 215--225 Notch regulates numb: integration of conditional and autonomous cell fate specification. [FBrf0212636] Richards et al., 2011, Cell Death Differ. 18(2): 191--200 Dendritic spine loss and neurodegeneration is rescued by Rab11 in models of Huntington's disease. [FBrf0212712] Sousa-Nunes et al., 2011, Nature 471(7339): 508--512 Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila. [FBrf0214426] Stagg et al., 2011, Development 138(11): 2171--2183 Dual role for Drosophila lethal of scute in CNS midline precursor formation and dopaminergic neuron and motoneuron cell fate. [FBrf0213671] Tan et al., 2011, Development 138(11): 2197--2206 Coordinated expression of cell death genes regulates neuroblast apoptosis. [FBrf0213685] Vallejo et al., 2011, EMBO J. 30(4): 756--769 Targeting Notch signalling by the conserved miR-8/200 microRNA family in development and cancer cells. [FBrf0213063] Viktorin et al., 2011, Dev. Biol. 356(2): 553--565 Multipotent neural stem cells generate glial cells of the central complex through transit amplifying intermediate progenitors in Drosophila brain development. [FBrf0214495] Vrailas-Mortimer et al., 2011, Dev. Cell 21(4): 783--795 A Muscle-Specific p38 MAPK/Mef2/MnSOD Pathway Regulates Stress, Motor Function, and Life Span in Drosophila. [FBrf0216446] Wang et al., 2011, Dev. Biol. 350(2): 414--428 Notch signaling regulates neuroepithelial stem cell maintenance and neuroblast formation in Drosophila optic lobe development. [FBrf0212909] Wang et al., 2011, Int. J. Dev. Biol. 55(2): 223--227 Spatially controlled expression of the Drosophila pseudouridine synthase RluA-1. [FBrf0213886] Yamasaki et al., 2011, Genes Cells 16(8): 896--909 Robust specification of sensory neurons by dual functions of charlatan, a Drosophila NRSF/REST-like repressor of extramacrochaetae and hairy. [FBrf0214536] Yu et al., 2011, BMC Cell Biol. 12: 9 Targeting the motor regulator Klar to lipid droplets. [FBrf0213230] Ashton-Beaucage et al., 2010, Cell 143(2): 251--262 The exon junction complex controls the splicing of MAPK and other long intron-containing transcripts in Drosophila. [FBrf0212064] Berger et al., 2010, Dev. Biol. 337(2): 415--424 Cell cycle independent role of Cyclin E during neural cell fate specification in Drosophila is mediated by its regulation of Prospero function. [FBrf0209814] Brankatschk and Eaton, 2010, J. Neurosci. 30(31): 10441--10447 Lipoprotein particles cross the blood-brain barrier in Drosophila. [FBrf0211445] Cordero and Cagan, 2010, Dev. Dyn. 239(3): 875--884 Canonical wingless signaling regulates cone cell specification in the Drosophila retina. [FBrf0210104] Fan et al., 2010, Cell Death Differ. 17(6): 912--921 Dual roles of Drosophila p53 in cell death and cell differentiation. [FBrf0210741] Fernández-Ayala et al., 2010, PLoS ONE 5(1): e8549 Gene expression in a Drosophila model of mitochondrial disease. [FBrf0209705] Fraichard et al., 2010, Dev. Biol. 340(2): 504--517 Tenectin is a novel alphaPS2betaPS integrin ligand required for wing morphogenesis and male genital looping in Drosophila. [FBrf0210522] Ghosh et al., 2010, Dev. Biol. 347(2): 271--278 The Drosophila gap gene giant regulates ecdysone production through specification of the PTTH-producing neurons. [FBrf0212090] Houalla et al., 2010, Mol. Brain 3: 19 Rab-mediated vesicular transport is required for neuronal positioning in the developing Drosophila visual system. [FBrf0211130] Kim et al., 2010, Mol. Cells 29(1): 93--98 Blood-brain barrier defects associated with Rbp9 mutation. [FBrf0210543] Kitajima et al., 2010, Dev. Biol. 347(1): 9--23 Progenitor properties of symmetrically dividing Drosophila neuroblasts during embryonic and larval development. [FBrf0211968] Lopes and Casares, 2010, Dev. Biol. 339(1): 78--88 hth maintains the pool of eye progenitors and its downregulation by Dpp and Hh couples retinal fate acquisition with cell cycle exit. [FBrf0210055] Lorbeck et al., 2010, Gene 450(1-2): 8--17 The histone demethylase Dmel\Kdm4A controls genes required for life span and male-specific sex determination in Drosophila. [FBrf0209540] Papadopoulos et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(9): 4087--4092 Function and specificity of synthetic Hox transcription factors in vivo. [FBrf0210157] Pérez et al., 2010, J. Insect Physiol. 56(1): 8--13 The enzyme NBAD-synthase plays diverse roles during the life cycle of Drosophila melanogaster. [FBrf0209498] Rendic et al., 2010, Glycobiology 20(11): 1353--1365 Neural-specific {alpha}3-fucosylation of N-linked glycans in the Drosophila embryo requires Fucosyltransferase A and influences developmental signaling associated with O-glycosylation. [FBrf0212026] Repnikova et al., 2010, J. Neurosci. 30(18): 6466--6476 Sialyltransferase regulates nervous system function in Drosophila. [FBrf0210736] Robinett et al., 2010, PLoS Biol. 8(5): e1000365 Sex and the single cell. II. There is a time and place for sex. [FBrf0210735] Roignant et al., 2010, Development 137(2): 273--281 The transcriptional co-factor Chip acts with LIM-homeodomain proteins to set the boundary of the eye field in Drosophila. [FBrf0209594] Roignant and Treisman, 2010, Cell 143(2): 238--250 Exon Junction Complex Subunits Are Required to Splice Drosophila MAP Kinase, a Large Heterochromatic Gene. [FBrf0212083] Salzer and Kumar, 2010, PLoS ONE 5(1): e8510 Identification of retinal transformation hot spots in developing Drosophila epithelia. [FBrf0209699] Salzer et al., 2010, Genetics 184(1): 185--197 The retinal determination gene eyes absent is regulated by the EGF receptor pathway throughout development in Drosophila. [FBrf0209690] Siegrist et al., 2010, Curr. Biol. 20(7): 643--648 Inactivation of both foxo and reaper promotes long-term adult neurogenesis in Drosophila. [FBrf0210555] Soller et al., 2010, Biochem. Soc. Trans. 38(4): 1122--1124 Determinants of ELAV gene-specific regulation. [FBrf0211339] Song et al., 2010, Development 137(21): 3719--3727 Disabled is a bona fide component of the Abl signaling network. [FBrf0212092] Swanson et al., 2010, Dev. Cell 18(3): 359--370 Structural Rules and Complex Regulatory Circuitry Constrain Expression of a Notch- and EGFR-Regulated Eye Enhancer. [FBrf0210200] Tamura et al., 2010, J. Neurosci. 30(42): 14091--14101 Drosophila PQBP1 regulates learning acquisition at projection neurons in aversive olfactory conditioning. [FBrf0212135] Thomsen et al., 2010, Development 137(17): 2951--2960 Developmental RNA processing of 3'UTRs in Hox mRNAs as a context-dependent mechanism modulating visibility to microRNAs. [FBrf0211493] Tsuda et al., 2010, FEBS Lett. 584(22): 4689--4694 POSH promotes cell survival in Drosophila and in human RASF cells. [FBrf0212255] Xiong et al., 2010, J. Cell Biol. 191(1): 211--223 Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury. [FBrf0211939] Zeng et al., 2010, genesis 48(10): 607--611 Characterization of midgut stem cell- and enteroblast-specific Gal4 lines in drosophila. [FBrf0212138] zur Lage and Jarman, 2010, BMC Dev. Biol. 10: 34 The function and regulation of the bHLH gene, cato, in Drosophila neurogenesis. [FBrf0210540] Show all research papers ...
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