The gene embryonic lethal abnormal vision is referred to in FlyBase by the symbol Dmel\elav (CG4262, FBgn0260400). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: poly(U) RNA binding; RNA binding. There is experimental evidence that it is involved in the biological process: central nervous system development; negative regulation of mRNA 3'-end processing. 80 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; organ system; adult segment; embryonic/larval neuron; adult; external compound sense organ; cell part; rhabdomere; pioneer neuron; EG neuron; thoracic segment; cell projection; peripheral nervous system. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Nucleotide-binding, alpha-beta plait; Paraneoplastic encephalomyelitis antigen; RNA recognition motif domain; Splicing factor ELAV/HuD. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult thoracico-abdominal ganglion. Comments on Affy2 ProbeSet: ProbeSet 1636615_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of elav. Gene sequence location is X:403545..417259.
User Contributed Data
External Summaries
Phenotypic Description from the Red Book (Lindsley
& Zimm 1992)
Gene/Allele symbols may differ
from current usage
elav: embryonic lethal, abnormal vision (J. C. Hall)
Embryonic lethal, or in the case of viable and
ostensibly hypomorphic alleles, displays poor jumping and flying ability plus aberrant visual physiology and behavior. No
morphological abnormalities visible in sections of dying
embryos (elav1, elav2, or elav3); however, whole-mount embryos
show periodic interruptions in the longitudinal connectives of
the CNS and missing commissures especially the posterior ones
(Jimenez and Campos-Ortega). elavts1 allows survival to adult
stage at 19-25 but viability is reduced and adults usually die
soon after eclosion; viability after rearing at 30 is very low
and newly emerged adults show poor coordination and die soon;
this temperature-sensitive allele also causes morphological
abnormalities in the brain, especially in the visual system
(after postembryonic shift from 19 to 30 or even following all
development at low-temperature); optic chiasma is abnormal and
second order optic lobe (medulla) is rotated to aberrant position (Campos et al., 1985); when elavts1 raised at 30, surface
of eye is rough and photoreceptor layer abnormal in sections
(Campos et al., 1985). Another temperature-sensitive allele
elav19 also induces abnormalities of visual system (Homyk et
al., 1985); rearing at 29 or high-temperature pulses delivered
to pupae, raised otherwise at 20, causes vacuolization of photoreceptors and disorganization of rhabdomeres; high-temperature rearing or pupal pulsing induces severe optic lobe
defects (absence of size reduction); electroretinograms of
this mutant, raised at high-temperature, are missing light-on
and light-off transient spikes (also seen after low-temperature rearing) and have reduction of ERG photoreceptor
potential; amplitude of this potential also deteriorates as
does deep pseudopupil when adults treated at high-temperature
after low-temperature rearing; mosaic analysis (Campos et al.,
1985) of elav1 reveals autonomously induced defects in eye
morphology, but no effects on other imaginal disc derivatives,
and suggests both directly induced defects in optic lobe
development, as well as inductively caused CNS defects mediated through expression of this mutation in the eye (i. e.,
such that the visual system's ganglia are genotypically normal). Lethal "focusing" in these mosaics suggests influence
of gene on derivatives of ventral blastoderm. In studies of
viable alleles, elav19 and elav20, both of which are
temperature-sensitive, flying and jumping ability shown to be
especially aberrant after rearing at 29; wing position also
aberrant; elavts1 most severe, including having no optomotor
response when raised at high (or even low) temperature;
temperature-sensitive period for aberrant wing posture in
elav19 extends from larval to pupal period (Homyk and Grigliatti). An antibody specific to neuronal nuclei fails to stain
neurons of elav-deficient embryos; however, the quantity of
antigen does not respond to the number of elav+ genes present
(Bier, Ackerman, Barbel, Jan and Jan, 1988, Science
240: 913-16). elav transcripts detected in all postmitotic
neurons, from their birth; not seen in embryonic or larval
neuroblasts. Also seen in larval eye discs, adult retinas and
Johnston's organ of the antennae.
Recent Updates
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There is a discrepancy between the in situ localisation (12C) and the molecular localisation based on the flanking sequence (1B5--1B6) for the "l(1)G0031" (elavG0031) line. The available data suggests that it is most likely that the molecular localisation (1B5--1B6) is correct and that the in situs were misinterpreted.
The elav protein, which contains RNA-binding motifs, is distributed non-uniformly in the nucleus, and may be part of a larger ribonucleoprotein complex.
staining is first visible in the R8 cells immediately posterior to the morphogenetic furrow and continues as other photoreceptors are recruited into the cluster.
Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult thoracico-abdominal ganglion.
[download data (TSV)]
Guide to FlyAtlas expression level colors
No expression (0 - 9.999)
Low expression (10 - 99.999)
Moderate expression (100 - 499.999)
High level expression (500 - 999.999)
Very high expression (>999.999)
Linear, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
524.525
Larval Midgut
14.8
Larval Hindgut
27.5
Larval Malpighian Tubules
23.6
Larval Fat Body
7.5
Larval Salivary Gland
18.2
Larval Trachea
61.325
Larval Carcass
28.05
Adult Head
72.3
Adult Eye
251.825
Adult Brain
816.6
Adult Thoracic-Abdominal Ganglion
394.2
Adult Crop
83.1
Adult Midgut
21.1
Adult Hindgut
76.7
Adult Malpighian Tubules
33.8
Adult Fat Body
25.8
Adult Salivary Gland
31.5
Adult Heart
59.875
Adult VirginFemale Spermatheca
29.5
Adult InseminatedFemale Spermatheca
33
Adult Ovary
6.5
Adult Testis
7
Adult Male Accessory Gland
26.1
Adult Carcass
28.3
Expression Level Scale
None
Low
Moderate
High
Linear, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
524.525
Larval Midgut
14.8
Larval Hindgut
27.5
Larval Malpighian Tubules
23.6
Larval Fat Body
7.5
Larval Salivary Gland
18.2
Larval Trachea
61.325
Larval Carcass
28.05
Adult Head
72.3
Adult Eye
251.825
Adult Brain
(816.6)
Adult Thoracic-Abdominal Ganglion
394.2
Adult Crop
83.1
Adult Midgut
21.1
Adult Hindgut
76.7
Adult Malpighian Tubules
33.8
Adult Fat Body
25.8
Adult Salivary Gland
31.5
Adult Heart
59.875
Adult VirginFemale Spermatheca
29.5
Adult InseminatedFemale Spermatheca
33
Adult Ovary
6.5
Adult Testis
7
Adult Male Accessory Gland
26.1
Adult Carcass
28.3
Expression Level Scale
None
Low
Moderate
High
Linear, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
524.525
Larval Midgut
14.8
Larval Hindgut
27.5
Larval Malpighian Tubules
23.6
Larval Fat Body
7.5
Larval Salivary Gland
18.2
Larval Trachea
61.325
Larval Carcass
28.05
Adult Head
72.3
Adult Eye
251.825
Adult Brain
816.6
Adult Thoracic-Abdominal Ganglion
394.2
Adult Crop
83.1
Adult Midgut
21.1
Adult Hindgut
76.7
Adult Malpighian Tubules
33.8
Adult Fat Body
25.8
Adult Salivary Gland
31.5
Adult Heart
59.875
Adult VirginFemale Spermatheca
29.5
Adult InseminatedFemale Spermatheca
33
Adult Ovary
6.5
Adult Testis
7
Adult Male Accessory Gland
26.1
Adult Carcass
28.3
Expression Level Scale
None
Low
Moderate
High
Very high
Linear, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
524.525
Larval Midgut
14.8
Larval Hindgut
27.5
Larval Malpighian Tubules
23.6
Larval Fat Body
7.5
Larval Salivary Gland
18.2
Larval Trachea
61.325
Larval Carcass
28.05
Adult Head
72.3
Adult Eye
251.825
Adult Brain
816.6
Adult Thoracic-Abdominal Ganglion
394.2
Adult Crop
83.1
Adult Midgut
21.1
Adult Hindgut
76.7
Adult Malpighian Tubules
33.8
Adult Fat Body
25.8
Adult Salivary Gland
31.5
Adult Heart
59.875
Adult VirginFemale Spermatheca
29.5
Adult InseminatedFemale Spermatheca
33
Adult Ovary
6.5
Adult Testis
7
Adult Male Accessory Gland
26.1
Adult Carcass
28.3
Expression Level Scale
Very high
log, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
524.525
Larval Midgut
14.8
Larval Hindgut
27.5
Larval Malpighian Tubules
23.6
Larval Fat Body
7.5
Larval Salivary Gland
18.2
Larval Trachea
61.325
Larval Carcass
28.05
Adult Head
72.3
Adult Eye
251.825
Adult Brain
816.6
Adult Thoracic-Abdominal Ganglion
394.2
Adult Crop
83.1
Adult Midgut
21.1
Adult Hindgut
76.7
Adult Malpighian Tubules
33.8
Adult Fat Body
25.8
Adult Salivary Gland
31.5
Adult Heart
59.875
Adult VirginFemale Spermatheca
29.5
Adult InseminatedFemale Spermatheca
33
Adult Ovary
6.5
Adult Testis
7
Adult Male Accessory Gland
26.1
Adult Carcass
28.3
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
524.525
Larval Midgut
14.8
Larval Hindgut
27.5
Larval Malpighian Tubules
23.6
Larval Fat Body
7.5
Larval Salivary Gland
18.2
Larval Trachea
61.325
Larval Carcass
28.05
Adult Head
72.3
Adult Eye
251.825
Adult Brain
(816.6)
Adult Thoracic-Abdominal Ganglion
394.2
Adult Crop
83.1
Adult Midgut
21.1
Adult Hindgut
76.7
Adult Malpighian Tubules
33.8
Adult Fat Body
25.8
Adult Salivary Gland
31.5
Adult Heart
59.875
Adult VirginFemale Spermatheca
29.5
Adult InseminatedFemale Spermatheca
33
Adult Ovary
6.5
Adult Testis
7
Adult Male Accessory Gland
26.1
Adult Carcass
28.3
Expression Level Scale
None
Low
Moderate
High
log, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
524.525
Larval Midgut
14.8
Larval Hindgut
27.5
Larval Malpighian Tubules
23.6
Larval Fat Body
7.5
Larval Salivary Gland
18.2
Larval Trachea
61.325
Larval Carcass
28.05
Adult Head
72.3
Adult Eye
251.825
Adult Brain
816.6
Adult Thoracic-Abdominal Ganglion
394.2
Adult Crop
83.1
Adult Midgut
21.1
Adult Hindgut
76.7
Adult Malpighian Tubules
33.8
Adult Fat Body
25.8
Adult Salivary Gland
31.5
Adult Heart
59.875
Adult VirginFemale Spermatheca
29.5
Adult InseminatedFemale Spermatheca
33
Adult Ovary
6.5
Adult Testis
7
Adult Male Accessory Gland
26.1
Adult Carcass
28.3
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
524.525
Larval Midgut
14.8
Larval Hindgut
27.5
Larval Malpighian Tubules
23.6
Larval Fat Body
7.5
Larval Salivary Gland
18.2
Larval Trachea
61.325
Larval Carcass
28.05
Adult Head
72.3
Adult Eye
251.825
Adult Brain
816.6
Adult Thoracic-Abdominal Ganglion
394.2
Adult Crop
83.1
Adult Midgut
21.1
Adult Hindgut
76.7
Adult Malpighian Tubules
33.8
Adult Fat Body
25.8
Adult Salivary Gland
31.5
Adult Heart
59.875
Adult VirginFemale Spermatheca
29.5
Adult InseminatedFemale Spermatheca
33
Adult Ovary
6.5
Adult Testis
7
Adult Male Accessory Gland
26.1
Adult Carcass
28.3
Expression Level Scale
None
Low
Moderate
High
Very high
Heatmap
Tissue
Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass
FlyAtlas Organ/Tissue Expression, larval vs. adult
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages.
[download data (TSV)]
Please Note FlyBase no
longer curates genomic clone accessions so this list
may not be complete
cDNA Clones ( 152 )
Please Note
This section lists
cDNAs and ESTs that fall within the genomic extent
of the gene model, which may include cDNAs and ESTs
of genes within introns, or of overlapping genes.
Please see GBrowse for alignment of the cDNAs and ESTs
to the gene model.
A sequence comparison and numerical analysis of the RRM-containing (RNA recognition motif) proteins suggests that functionally related RRM-containing proteins have significant sequence similarities in their RRMs.
Embryonic lethal, or in the case of viable and ostensibly hypomorphic alleles, displays poor jumping and flying ability plus aberrant visual physiology and behavior. No morphological abnormalities visible in sections of dying embryos (elav1, elav2, or elav3). elavts1 allows survival to adult stage at 19oC-25oC but viability is reduced and adults usually die soon after eclosion; viability after rearing at 30oC is very low and newly emerged adults show poor coordination and die soon; this temperature-sensitive allele also causes morphological abnormalities in the brain, especially in the visual system (after postembryonic shift from 19oC to 30oC or even following all development at low-temperature). In studies of viable alleles, elav19 and elav20, both of which are temperature-sensitive, flying and jumping ability shown to be especially aberrant after rearing at 29oC; wing position also aberrant; elavts1 most severe, including having no optomotor response when raised at high (or even low) temperature.
The divergence of the gene sequences in the amino terminal region reflects lowered functional constraint, rather than species-specific functional specification.
RNA localisation studies demonstrate that the elav gene product provides a function which is required for the proper development and maintenance of all neurons.
Mosaic analysis of elav1 suggests both directly induced defects in optic lobe development, as well as inductively caused CNS defects mediated through expression of this mutation in the eye (i. e., such that the visual system's ganglia are genotypically normal). Lethal "focusing" in elav1 mosaics suggests influence of gene on derivatives of ventral blastoderm.
elav gene function is autonomously essential in the eye, is essential for normal development of the optic lobes and not necessary in most major imaginal disc cell derivatives with the exception of the eye disc.
Ecdysone-dependent and ecdysone-independent programmed cell death in the developing optic lobe of Drosophila. [FBrf0220563]
Melom and Littleton, 2013, J. Neurosci. 33(3): 1169--1178
Mutation of a NCKX Eliminates Glial Microdomain Calcium Oscillations and Enhances Seizure Susceptibility. [FBrf0220564]
Angus et al., 2012, Oncogene 31(2): 238--250
Willin/FRMD6 expression activates the Hippo signaling pathway kinases in mammals and antagonizes oncogenic YAP. [FBrf0217212]
Ardekani et al., 2012, PLoS ONE 7(7): e40506
Using GFP Video to Track 3D Movement and Conditional Gene Expression in Free-Moving Flies. [FBrf0218989]
Beck et al., 2012, J. Neurosci. 32(20): 7058--7073
Regulation of Fasciclin II and Synaptic Terminal Development by the Splicing Factor Beag. [FBrf0218385]
Berger et al., 2012, Cell Rep. 2(2): 407--418
FACS Purification and Transcriptome Analysis of Drosophila Neural Stem Cells Reveals a Role for Klumpfuss in Self-Renewal. [FBrf0219320]
Berni et al., 2012, Curr. Biol. 22(20): 1861--1870
Autonomous circuitry for substrate exploration in freely moving Drosophila larvae. [FBrf0219792]
Bhaskar et al., 2012, Gene Expr. Patterns 12(1-2): 77--84
Dynamic pattern of expression of dlin52, a member of the Myb/MuvB complex, during Drosophila development. [FBrf0217411]
Bolkan et al., 2012, J. Neurosci. 32(46): 16181--16192
beta-Secretase Cleavage of the Fly Amyloid Precursor Protein Is Required for Glial Survival. [FBrf0219983]
Bousquet et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(1): 249--254
Expression of a desaturase gene, desat1, in neural and nonneural tissues separately affects perception and emission of sex pheromones in Drosophila. [FBrf0217137]
Callan et al., 2012, Brain Res. 1462: 151--161
Fragile X Protein is required for inhibition of insulin signaling and regulates glial-dependent neuroblast reactivation in the developing brain. [FBrf0218552]
Chen et al., 2012, Dev. Neurobiol. 72(11): 1422--1432
The POU-domain protein Pdm3 regulates axonal targeting of R neurons in the Drosophila ellipsoid body. [FBrf0219674]
Chen and Ganetzky, 2012, J. Cell Biol. 196(4): 529--543
A neuropeptide signaling pathway regulates synaptic growth in Drosophila. [FBrf0217500]
Christiansen et al., 2012, Mech. Dev. 129(5-8): 98--108
Ligand-independent activation of the Hedgehog pathway displays non-cell autonomous proliferation during eye development in Drosophila. [FBrf0219046]
Distefano et al., 2012, Dev. Dyn. 241(3): 553--562
Drosophila lilliputian is required for proneural gene expression in retinal development. [FBrf0217520]
Dornier et al., 2012, J. Cell Biol. 199(3): 481--496
TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals. [FBrf0219816]
Giagtzoglou et al., 2012, J. Cell Biol. 196(1): 65--83
dEHBP1 Controls Exocytosis and Recycling of Delta During Asymmetric Divisions. [FBrf0217836]
Hilgers et al., 2012, Genes Dev. 26(20): 2259--2264
ELAV mediates 3' UTR extension in the Drosophila nervous system. [FBrf0219699]
Hsiao et al., 2012, J. Vis. Exp.:
Dissection and immunohistochemistry of larval, pupal and adult Drosophila retinas. [FBrf0220029]
Kametaka et al., 2012, J. Cell Sci. 125(3): 634--648
AP-1 clathrin adaptor and CG8538/Aftiphilin are involved in Notch signaling during eye development in Drosophila melanogaster. [FBrf0217589]
Kanakousaki and Gibson, 2012, Development 139(15): 2751--2762
A differential requirement for SUMOylation in proliferating and non-proliferating cells during Drosophila development. [FBrf0218825]
Lai et al., 2012, Dev. Cell 23(4): 849--857
The snail family member worniu is continuously required in neuroblasts to prevent elav-induced premature differentiation. [FBrf0219754]
Legent et al., 2012, Genetics 190(2): 601--616
A screen for x-linked mutations affecting Drosophila photoreceptor differentiation identifies casein kinase 1α as an essential negative regulator of wingless signaling. [FBrf0217484]
Miguel et al., 2012, Neurobiol. Aging 33(5): 1008.e1--1008.e15
Accumulation of insoluble forms of FUS protein correlates with toxicity in Drosophila. [FBrf0217826]
Moraru et al., 2012, Neural Dev. 7(1): 14
Analysis of cell identity, morphology, apoptosis and mitotic activity in a primary neural cell culture system in Drosophila. [FBrf0218691]
Mukherjee et al., 2012, G3 (Bethesda) 2(1): 23--28
Genetic analysis of fibroblast growth factor signaling in the Drosophila eye. [FBrf0217664]
Nakazawa et al., 2012, Dev. Dyn. 241(5): 965--974
A novel Cre/loxP system for mosaic gene expression in the Drosophila embryo. [FBrf0218072]
Nfonsam et al., 2012, PLoS ONE 7(8): e44583
Analysis of the Transcriptomes Downstream of Eyeless and the Hedgehog, Decapentaplegic and Notch Signaling Pathways in Drosophila melanogaster. [FBrf0219414]
Plavicki et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(5): 1578--1583
Homeobox gene distal-less is required for neuronal differentiation and neurite outgrowth in the Drosophila olfactory system. [FBrf0217395]
Popkova et al., 2012, PLoS Genet. 8(12): e1003159
Polycomb controls gliogenesis by regulating the transient expression of the gcm/glide fate determinant. [FBrf0220515]
Rezaval et al., 2012, Curr. Biol. 22(13): 1155--1165
Hibris, a Drosophila Nephrin Homolog, Is Required for Presenilin-Mediated Notch and APP-like Cleavages. [FBrf0218978]
Smibert et al., 2012, Cell Rep. 1(3): 277--289
Global Patterns of Tissue-Specific Alternative Polyadenylation in Drosophila. [FBrf0218523]
Song and Lu, 2012, J. Biol. Chem. 287(21): 17716--17728
Interaction of Notch Signaling Modulator Numb with α-Adaptin Regulates Endocytosis of Notch Pathway Components and Cell Fate Determination of Neural Stem Cells. [FBrf0218342]
Stephan et al., 2012, J. Neurosci. 32(46): 16080--16094
Drosophila Psidin Regulates Olfactory Neuron Number and Axon Targeting through Two Distinct Molecular Mechanisms. [FBrf0220017]
Sun et al., 2012, PLoS Genet. 8(2): e1002515
Neurophysiological Defects and Neuronal Gene Deregulation in Drosophila mir-124 Mutants. [FBrf0217508]
Suyari et al., 2012, Gene 495(2): 104--114
Differential requirement for the N-terminal catalytic domain of the DNA polymerase ε p255 subunit in the mitotic cell cycle and the endocycle. [FBrf0217428]
Tunstall et al., 2012, PLoS ONE 7(4): e35641
A Screen for Genes Expressed in the Olfactory Organs of Drosophila melanogaster Identifies Genes Involved in Olfactory Behaviour. [FBrf0218110]
Verghese et al., 2012, Cell Death Differ. 19(10): 1664--1676
Hippo signalling controls Dronc activity to regulate organ size in Drosophila. [FBrf0219371]
Volders et al., 2012, J. Neurosci. 32(43): 15193--15204
Drosophila rugose Is a Functional Homolog of Mammalian Neurobeachin and Affects Synaptic Architecture, Brain Morphology, and Associative Learning. [FBrf0219807]
Wang and Sun, 2012, Development 139(18): 3413--3421
Segregation of eye and antenna fates maintained by mutual antagonism in Drosophila. [FBrf0219201]
Weber et al., 2012, Genetics 191(1): 145--162
Novel regulators of planar cell polarity: a genetic analysis in Drosophila. [FBrf0218210]
Weng and Cohen, 2012, Development 139(8): 1427--1434
Drosophila miR-124 regulates neuroblast proliferation through its target anachronism. [FBrf0217785]
Xia et al., 2012, Mol. Neurodegener. 7: 10
Motor neuron apoptosis and neuromuscular junction perturbation are prominent features in a Drosophila model of Fus-mediated ALS. [FBrf0218020]
Yamakawa et al., 2012, Development 139(3): 558--567
Deficient Notch signaling associated with neurogenic pecanex is compensated for by the unfolded protein response in Drosophila. [FBrf0217160]
Yoshiura et al., 2012, Dev. Cell 22(1): 79--91
Tre1 GPCR Signaling Orients Stem Cell Divisions in the Drosophila Central Nervous System. [FBrf0217269]
Yu et al., 2012, genesis 50(5): 393--403
Identification of Bombyx atonal and functional comparison with the Drosophila atonal proneural factor in the developing fly eye. [FBrf0218282]
Zanini et al., 2012, Genes Brain Behav. 11(7): 819--827
Deletion of the Drosophila neuronal gene found in neurons disrupts brain anatomy and male courtship. [FBrf0219541]
Zappia et al., 2012, BMC Neurosci. 13: 78
A role for the membrane protein M6 in the Drosophila visual system. [FBrf0219384]
Zhai et al., 2012, PLoS Genet. 8(3): e1002582
Antagonistic regulation of apoptosis and differentiation by the cut transcription factor represents a tumor-suppressing mechanism in Drosophila. [FBrf0217859]
Anderson et al., 2011, Development 138(10): 1957--1966
The enhancer of trithorax and polycomb gene Caf1/p55 is essential for cell survival and patterning in Drosophila development. [FBrf0213580]
Belacortu et al., 2011, Gene Expr. Patterns 11(3-4): 190--201
Expression of Drosophila Cabut during early embryogenesis, dorsal closure and nervous system development. [FBrf0213309]
Benchabane et al., 2011, EMBO J. 30(8): 1444--1458
Jerky/Earthbound facilitates cell-specific Wnt/Wingless signalling by modulating β-catenin-TCF activity. [FBrf0213544]
Benhra et al., 2011, Curr. Biol. 21(1): 87--95
AP-1 Controls the Trafficking of Notch and Sanpodo toward E-Cadherin Junctions in Sensory Organ Precursors. [FBrf0212697]
Besson et al., 2011, J. Comp. Neurol. 519(14): 2734--2757
Involvement of the drosophila taurine/aspartate transporter dEAAT2 in selective olfactory and gustatory perceptions. [FBrf0214574]
Bhattacharya and Baker, 2011, Cell 147(4): 881--892
A Network of Broadly Expressed HLH Genes Regulates Tissue-Specific Cell Fates. [FBrf0216641]
Brockmann et al., 2011, Dev. Dyn. 240(1): 75--85
Regulation of ocellar specification and size by twin of eyeless and homothorax. [FBrf0212641]
Brumby et al., 2011, Genetics 188(1): 105--125
Identification of Novel Ras-Cooperating Oncogenes in Drosophila melanogaster: A RhoGEF/Rho-Family/JNK Pathway Is a Central Driver of Tumorigenesis. [FBrf0213630]
Chang et al., 2011, PLoS Genet. 7(2): e1001288
Pathogenic VCP/TER94 Alleles Are Dominant Actives and Contribute to Neurodegeneration by Altering Cellular ATP Level in a Drosophila IBMPFD Model. [FBrf0213008]
Charlton-Perkins et al., 2011, Neural Dev. 6: 20
Prospero and Pax2 combinatorially control neural cell fate decisions by modulating Ras- and Notch-dependent signaling. [FBrf0213993]
Chen et al., 2011, PLoS ONE 6(4): e18853
Highly Tissue Specific Expression of Sphinx Supports Its Male Courtship Related Role in Drosophila melanogaster. [FBrf0213606]
Chen et al., 2011, PLoS ONE 6(1): e16127
Genetic interaction of centrosomin and bazooka in apical domain regulation in Drosophila photoreceptor. [FBrf0212822]
Cho and Fischer, 2011, Development 138(7): 1349--1359
Ral GTPase promotes asymmetric Notch activation in the Drosophila eye in response to Frizzled/PCP signaling by repressing ligand-independent receptor activation. [FBrf0213208]
Colonques et al., 2011, PLoS ONE 6(4): e19342
A Transient Expression of Prospero Promotes Cell Cycle Exit of Drosophila Postembryonic Neurons through the Regulation of Dacapo. [FBrf0213608]
Datta et al., 2011, Dev. Biol. 360(2): 391--402
A dissection of the teashirt and tiptop genes reveals a novel mechanism for regulating transcription factor activity. [FBrf0216557]
Duan et al., 2011, EMBO J. 30(15): 3120--3133
Insensitive is a corepressor for Suppressor of Hairless and regulates Notch signalling during neural development. [FBrf0214638]
Endo et al., 2011, Nat. Neurosci. 15(2): 224--233
Chromatin modification of Notch targets in olfactory receptor neuron diversification. [FBrf0217319]
Feng et al., 2011, EMBO Rep. 12(2): 157--163
Loss of the Polycomb group gene polyhomeotic induces non-autonomous cell overproliferation. [FBrf0214189]
Freer et al., 2011, Gene Expr. Patterns 11(8): 533--546
Molecular and functional analysis of Drosophila single-minded larval central brain expression. [FBrf0216483]
Ghosh et al., 2011, PLoS ONE 6(7): e22735
Targeted ablation of oligodendrocytes triggers axonal damage. [FBrf0214594]
Goda et al., 2011, PLoS Genet. 7(7): e1002167
Adult Circadian Behavior in Drosophila Requires Developmental Expression of cycle, But Not period. [FBrf0214302]
Gontang et al., 2011, Development 138(22): 4899--4909
The cytoskeletal regulator Genghis khan is required for columnar target specificity in the Drosophila visual system. [FBrf0216508]
Hakeda-Suzuki et al., 2011, Nat. Neurosci. 14(3): 314--323
Golden Goal collaborates with Flamingo in conferring synaptic-layer specificity in the visual system. [FBrf0213128]
Hartl et al., 2011, J. Neurosci. 31(44): 15660--15673
A New Prospero and microRNA-279 Pathway Restricts CO2 Receptor Neuron Formation. [FBrf0216631]
Hasegawa et al., 2011, Development 138(5): 983--993
Concentric zones, cell migration and neuronal circuits in the Drosophila visual center. [FBrf0213020]
Haussmann et al., 2011, Genetics 189(1): 97--107
ELAV-Mediated 3'-End Processing of ewg Transcripts Is Evolutionarily Conserved Despite Sequence Degeneration of the ELAV-Binding Site. [FBrf0215270]
Hilgers et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(38): 15864--15869
Neural-specific elongation of 3' UTRs during Drosophila development. [FBrf0215804]
Jepson et al., 2011, J. Biol. Chem. 286(10): 8325--8337
Engineered Alterations in RNA Editing Modulate Complex Behavior in Drosophila: REGULATORY DIVERSITY OF ADENOSINE DEAMINASE ACTING ON RNA (ADAR) TARGETS. [FBrf0213236]
Jiang et al., 2011, Oncogene 30(29): 3248--3260
Sds22/PP1 links epithelial integrity and tumor suppression via regulation of myosin II and JNK signaling. [FBrf0214488]
Karim and Moore, 2011, J. Neurosci. 31(47): 17017--17027
Convergent local identity and topographic projection of sensory neurons. [FBrf0216770]
Kawamori et al., 2011, Dev. Growth Differ. 53(5): 653--667
Fat / Hippo pathway regulates the progress of neural differentiation signaling in the Drosophila optic lobe. [FBrf0213932]
Keene et al., 2011, J. Neurosci. 31(17): 6527--6534
Kuzina et al., 2011, Development 138(9): 1839--1849
How Notch establishes longitudinal axon connections between successive segments of the Drosophila CNS. [FBrf0213493]
Lieber et al., 2011, Neuron 69(3): 468--481
DSL-Notch Signaling in the Drosophila Brain in Response to Olfactory Stimulation. [FBrf0212999]
Lin et al., 2011, PLoS ONE 6(6): e20371
Neuronal Function and Dysfunction of Drosophila dTDP. [FBrf0213971]
Ling and Salvaterra, 2011, PLoS ONE 6(3): e17762
Robust RT-qPCR Data Normalization: Validation and Selection of Internal Reference Genes during Post-Experimental Data Analysis. [FBrf0213272]
Mirkovic et al., 2011, Nat. Struct. Mol. Biol. 18(6): 665--672
Nemo kinase phosphorylates β-catenin to promote ommatidial rotation and connects core PCP factors to E-cadherin-β-catenin. [FBrf0213849]
Morante et al., 2011, Development 138(4): 687--693
Cell migration in Drosophila optic lobe neurons is controlled by eyeless/Pax6. [FBrf0212874]
Morikawa et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(48): 19389--19394
Different levels of the Tripartite motif protein, Anomalies in sensory axon patterning (Asap), regulate distinct axonal projections of Drosophila sensory neurons. [FBrf0216734]
Muyskens and Guillemin, 2011, PLoS ONE 6(3): e17856
Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593
Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621]
Nicholson et al., 2011, Development 138(2): 251--260
Notch-dependent expression of the archipelago ubiquitin ligase subunit in the Drosophila eye. [FBrf0212669]
Ouyang et al., 2011, Development 138(11): 2185--2196
Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in Drosophila. [FBrf0213702]
Pak et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(30): 12390--12395
Mutation of the conserved polyadenosine RNA binding protein, ZC3H14/dNab2, impairs neural function in Drosophila and humans. [FBrf0214553]
Pandey et al., 2011, PLoS ONE 6(11): e28106
The Glucuronyltransferase GlcAT-P Is Required for Stretch Growth of Peripheral Nerves in Drosophila. [FBrf0216828]
Podratz et al., 2011, Neurobiol. Disease 43(2): 330--337
Drosophila melanogaster: A new model to study cisplatin-induced neurotoxicity. [FBrf0213891]
Popova et al., 2011, J. Cell Sci. 124(24): 4203--4212
Rb deficiency during Drosophila eye development deregulates EMC, causing defects in the development of photoreceptors and cone cells. [FBrf0217175]
Quijano et al., 2011, Genetics 189(3): 809--824
Wg Signaling via Zw3 and Mad Restricts Self-Renewal of Sensory Organ Precursor Cells in Drosophila. [FBrf0216675]
Rebeiz et al., 2011, Development 138(2): 215--225
Notch regulates numb: integration of conditional and autonomous cell fate specification. [FBrf0212636]
Reddy and Irvine, 2011, Development 138(23): 5201--5212
Regulation of Drosophila glial cell proliferation by Merlin-Hippo signaling. [FBrf0216584]
Richards et al., 2011, Cell Death Differ. 18(2): 191--200
Dendritic spine loss and neurodegeneration is rescued by Rab11 in models of Huntington's disease. [FBrf0212712]
San-Juán and Baonza, 2011, Dev. Biol. 352(1): 70--82
The bHLH factor deadpan is a direct target of Notch signaling and regulates neuroblast self-renewal in Drosophila. [FBrf0213150]
Shulman et al., 2011, Am. J. Hum. Genet. 88(2): 232--238
Functional Screening of Alzheimer Pathology Genome-wide Association Signals in Drosophila. [FBrf0212981]
Singh et al., 2011, Dev. Biol. 359(2): 199--208
Opposing interactions between homothorax and Lobe define the ventral eye margin of Drosophila eye. [FBrf0216526]
Smibert et al., 2011, RNA 17(11): 1997--2010
A Drosophila genetic screen yields allelic series of core microRNA biogenesis factors and reveals post-developmental roles for microRNAs. [FBrf0216392]
Sousa-Nunes et al., 2011, Nature 471(7339): 508--512
Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila. [FBrf0214426]
Sprecher et al., 2011, Dev. Biol. 358(1): 33--43
The Drosophila larval visual system: High-resolution analysis of a simple visual neuropil. [FBrf0215208]
Stagg et al., 2011, Development 138(11): 2171--2183
Dual role for Drosophila lethal of scute in CNS midline precursor formation and dopaminergic neuron and motoneuron cell fate. [FBrf0213671]
Stephan et al., 2011, Mol. Biol. Cell 22(21): 4079--4092
Membrane-targeted WAVE mediates photoreceptor axon targeting in the absence of the WAVE complex in Drosophila. [FBrf0216499]
Tan et al., 2011, Development 138(11): 2197--2206
Coordinated expression of cell death genes regulates neuroblast apoptosis. [FBrf0213685]
Vallejo et al., 2011, EMBO J. 30(4): 756--769
Targeting Notch signalling by the conserved miR-8/200 microRNA family in development and cancer cells. [FBrf0213063]
Viktorin et al., 2011, Dev. Biol. 356(2): 553--565
Multipotent neural stem cells generate glial cells of the central complex through transit amplifying intermediate progenitors in Drosophila brain development. [FBrf0214495]
Vrailas-Mortimer et al., 2011, Dev. Cell 21(4): 783--795
A Muscle-Specific p38 MAPK/Mef2/MnSOD Pathway Regulates Stress, Motor Function, and Life Span in Drosophila. [FBrf0216446]
Wang et al., 2011, J. Clin. Invest. 121(10): 4118--4126
The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span. [FBrf0216240]
Wang et al., 2011, Dev. Biol. 350(2): 414--428
Notch signaling regulates neuroepithelial stem cell maintenance and neuroblast formation in Drosophila optic lobe development. [FBrf0212909]
Wang et al., 2011, Int. J. Dev. Biol. 55(2): 223--227
Spatially controlled expression of the Drosophila pseudouridine synthase RluA-1. [FBrf0213886]
Xin et al., 2011, Development 138(22): 4955--4967
Erect Wing facilitates context-dependent Wnt/Wingless signaling by recruiting the cell-specific Armadillo-TCF adaptor Earthbound to chromatin. [FBrf0216486]
Xiong and Rebay, 2011, Dev. Dyn. 240(7): 1745--1755
Abelson tyrosine kinase is required for Drosophila photoreceptor morphogenesis and retinal epithelial patterning. [FBrf0213959]
Yamasaki et al., 2011, Genes Cells 16(8): 896--909
Robust specification of sensory neurons by dual functions of charlatan, a Drosophila NRSF/REST-like repressor of extramacrochaetae and hairy. [FBrf0214536]
Yu et al., 2011, BMC Cell Biol. 12: 9
Targeting the motor regulator Klar to lipid droplets. [FBrf0213230]
Zhang et al., 2011, PLoS ONE 6(7): e22278
Yki/YAP, Sd/TEAD and Hth/MEIS Control Tissue Specification in the Drosophila Eye Disc Epithelium. [FBrf0214606]
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