Gene Dmel\rad201

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General Information

Symbol

Dmel\rad201

Species

D. melanogaster

Name

radiation-resistant 201

Annotation symbol

Feature type

protein_coding_gene

FlyBase ID

FBgn0260438

Gene Model Status

Unannotated

Stock availability

2 publicly available

Also Known As

rad(2)201

Genomic Location

Chromosome (arm)

Recombination map

2-59.9 +/- 1.1

Cytogenetic map

45B1-45B1

Sequence location

Summary Information

Automatically generated summary

See sections below for more information

The gene radiation-resistant 201 is referred to in FlyBase by the symbol Dmel\rad201 (FBgn0260438). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 3 alleles are reported. The phenotypes of these alleles are annotated with: egg; oocyte; egg chamber. It has no annotated transcripts. Gene has not been localized to the genome sequence.

User Contributed Data

Beta version, feedback welcome

Phenotypic Description from the Red Book (Lindsley & Zimm 1992)

Gene/Allele symbols may differ from current usage

rad201: radiation sensitive

Survival of homozygous larvae more sensitive to exposure to γ radiation than controls; chromosome- and chromatid-aberration induction increased over control but ratio of the two types same as control. X-ray-induced X-chromosome loss in immature oocytes greater in rad201 than in control; mature oocytes show no effect of rad201. Post-treatment hyperthermia enhances the effect of irradiation in mature oocytes and control immature oocytes, but not in immature oocytes of rad201.

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

FB2013_02

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

45B1-45B1

Limits computationally determined from genome sequence between P{lacW}CG8788^k04512&P{lacW}l(2)k13412^k13412 and P{PZ}Pkn⁰⁶⁷³⁶

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-59.9 +/- 1.1

(Khromykh and Zakharow, 1981)

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Name

Mapped Features

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

modENCODE Anatomy RNA-Seq

modENCODE Development RNA-Seq

modENCODE Cell Lines RNA-Seq

modENCODE Treatments RNA-Seq

Expression Clusters

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

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FBgn0260438

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable

Other Phenotypes

Allele

chemical sensitive

radiation sensitive

rad201¹

Phenotype manifest in

Allele

egg

rad201¹

egg chamber

rad201¹

oocyte

rad201¹

Classical Alleles ( 3 )

For All Classical Alleles Show

Allele of rad201	Mutagen	Stocks	Known lesion
rad201¹		2	Yes
rad201^ZII-0670	ethyl methanesulfonate	0	Yes
rad201^ZII-2512	ethyl methanesulfonate	0	--

Alleles Carried on Transgenic Constructs ( 0 )

For All Alleles Carried on Transgenic Constructs Show

Allele of rad201	Class	Mutagen	Stocks	Known lesion

Aneuploid Aberrations

Disrupted in

Df(2R)G50-31

(Konev et al., 1994)

Df(2R)Np1

(Konev et al., 1994)

Df(2R)Np4

(Konev et al., 1994)

Df(2R)Np5

(Konev et al., 1994)

Df(2R)w45-15g

(Konev et al., 1994)

Df(2R)w45-30n

(Konev et al., 1994)

Df(2R)w45-31n

(Konev et al., 1994)

Df(2R)w73-1

(Konev et al., 1994)

Df(2R)w73-2

(Konev et al., 1994)

In(2R)G63^Lw45-73n^R

(Konev et al., 1994)

Not disrupted in

Df(2R)G75

(Konev et al., 1994)

Df(2R)w45-47n

(Konev et al., 1994)

Df(2R)w73-3

(Konev et al., 1994)

Df(2R)w73-4

(Konev et al., 1994)

Not duplicated in

Dp(2;Y)G6-1

(Konev et al., 1994)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

Insertions

Type of insertions

Name

Expression data

Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )

Terms Based on Experimental Evidence ( 0 terms )

Terms Based on Predictions or Assertions ( 0 terms )

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

rad201 allele

Gene

References

rad201¹

mei-9

(Sarantseva and Khromykh, 2001)

mei-41

(Sarantseva and Khromykh, 2001)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0260438

Orthologs

OrthoDB Orthologs (0) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

No orthologs identified

Dipteran inclusive ortholog search

No orthologs identified

Insect inclusive ortholog search

No orthologs identified

Arthropod inclusive ortholog search

No orthologs identified

Metazoa inclusive ortholog search

No orthologs identified

Orthologs in Drosophila Species (None identified)

No orthologies identified

Orthologs in non-Drosophila Dipterans (None identified)

No non-Drosophilid orthologies identified

Orthologs in non-Dipteran Insects (None identified)

No non-Dipteran orthologies identified

Orthologs in non-Insect Arthropods (None identified)

No non-Insect Arthropod orthologies identified

Orthologs in non-Arthropod Metazoa (None identified)

No non-Arthropod Metazoa orthologies identified

Human Orthologs (0)

Gene

OMIM

HGNC

AAA Orthologs (11) based on analysis using Dmel annotation version 4.3

Organism

Gene

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA20768

Drosophila persimilis

Dper\GL17461

Drosophila willistoni

Dwil\GK22866

Drosophila virilis

Dvir\GJ18563

Drosophila mojavensis

Dmoj\GI19818

Drosophila grimshawi

Dgri\GH19868

Stocks & Reagents

Stocks Listed in FlyBase ( 2 )

4207

107630

Genomic Clones ( 0 )

cDNA Clones ( 0 )

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

8680154

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

The "rad201[1]" chromosome contains a number of lesions in two different genes. These are: F50L in the CG42382 annotation, and K61E, V93A and Y108H in the CG2412 annotation (corresponding to the Rad51C gene). In addition, an opus element is inserted in the Rad51C promoter region approximately 400bp upstream of the start codon. This mutant allele was isolated from a natural population, and thus it is not known which of the lesions are neutral and which cause the mutant phenotype.

(Khromykh et al., 2008)

FlyBase curator comment: information corresponding to the "rad201" complementation group has been separated out from information corresponding to the "CG8016" annotation in FlyBase, since evidence suggests that the "rad201" complementation group instead may correspond to the neighbouring annotation, CG2412. In addition, the CG8016 annotation has been renamed CG42382 in release 5.10 of the genome annotation to avoid confusion. The "rad201" complementation group has not yet been associated with the CG2412 annotation in FlyBase, as a lesion in CG2412 was only found in one out of two rad201 alleles tested in this paper.

(Chaouki and Salz, 2006)

The "rad201" complementation group has been associated with the "CG8016" annotation on FlyBase. However, evidence suggests that "rad201" instead corresponds to the neighbouring annotation, CG2412; the "rad201¹" allele has a lesion within the CG2412 open reading frame (although no lesion has been found in the "rad201^ZII-0670" allele), and the protein encoded by CG2412 interacts with Spf45 protein.

(Chaouki and Salz, 2006)

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

Other Crossreferences

Linkouts

DroID - A comprehensive database of gene and protein interactions.

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