FB2020_06, released Dec 22, 2020
Gene: Dmel\spdo
FB2020_06, released Dec 22, 2020
Gene: Dmel\spdo
Gene: Dmel\spdo
Gene: Dmel\spdo
encodes a four-pass transmembrane protein that localizes to the cell membrane - specifies Notch-dependent fate - Notch and Numb physically associate with Sanpodo - enables precursor cells to divide asymmetrically to produce daughter cells of distinct fates - involved in cell fate specification in the nervous system, mesoderm, and endoderm
Please see the JBrowse view of Dmel\spdo for information on other features
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Gene model reviewed during 5.44
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\spdo using the Feature Mapper tool.
Comment: transient expression
Comment: transient expression
Comment: transient expression
Expression assayed at stages 9, 11, 13, and 17. Expression may be continuous between assayed stages in some tissues.
spdo protein is expressed in all embryonic cells known to undergo asymmetric divisions.
GBrowse - Visual display of RNA-Seq signals
View Dmel\spdo in GBrowse 23-100
3-100
3-98.4
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: spdo CG31020
Source for merge of: CG31020 BcDNA:RE23355
The "spdo" complementation group corresponds to the CG31020 annotation and not to "tmod" as previously reported in FBrf0102830; molecular lesions in the CG31020 annotation have been identified in 12 spdo alleles, RNAi against CG31020 results in a central nervous system (CNS) phenotype essentially identical to that of spdo mutants and expression of CG31020 throughout the CNS of spdo mutant embryos results in complete to near-complete rescue of the spdo CNS phenotype.
FlyBase curator comment: FBrf0102830 states that the "spdo" complementation group corresponds to the "tmod, tropomodulin" gene. However, FBrf0162056 shows that this was an error and the spdo complementation group actually corresponds to the CG31020 annotation.
The "spdo" complementation group corresponds to the CG31020 annotation and not to the CG1539 annotation. It was reported in FBrf0102830 that "spdo" corresponds to the "tmod, tropomodulin" gene (the CG1539 annotation). However, this was subsequently shown to be an error. FBrf0162056 shows that the "spdo" complementation group corresponds instead to the CG31020 annotation.
Source for merge of CG31020 BcDNA:RE23355 was a shared cDNA ( date:030728 ).
New annotation (CG31020) in release 3 of the genome annotation.
Two EMS induced alleles have been identified in a screen for mutations affecting commissure formation in the CNS of the embryo.
sanpodo is Korean for mountain grape.
spdo is required to define glial versus neuronal cell identity.
Mutation in spdo affects the neuronal lineage, causes transformation of support cells into neurons.
"sanpodo" is Korean for mountain grapes.
spdo is required for PNS development in the embryo.