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Gene Dmel\spdo

General Information
Symbol	Dmel\spdo	Species	D. melanogaster
Name	sanpodo	Annotation symbol	CG31020
Feature type	protein_coding_gene	FlyBase ID	FBgn0260440
Gene Model Status	Current	Stock availability	7 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	99F6-99F6	Sequence location	3R:26,302,411..26,304,571 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene sanpodo is referred to in FlyBase by the symbol Dmel\spdo (CG31020, FBgn0260440). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: Notch binding; protein binding. There is experimental evidence that it is involved in the biological process: negative regulation of Notch signaling pathway; heart morphogenesis; sensory organ development; Notch signaling pathway; sensory organ precursor cell division; asymmetric cell division. 21 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; hypodermal muscle of larval abdomen; abdominal dorsal bipolar neuron dbp; embryonic/larval neuron; peripheral nervous system; larval abdominal segment; non-connected developing system; adult segment; sense organ. It has one annotated transcript and one annotated polypeptide. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 06-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1637254_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of spdo. Gene sequence location is 3R:26302411..26304571.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features HFA13988 BKN24866
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 99F6-99F6   Limits computationally determined from genome sequence between P{PZ}ncd05884 and P{lacW}l(3)s2500s2500
Experimentally Determined Cytological Location
Cytogenetic map Notes References 99F1-100B5   (determined by in situ hybridisation)   (Salzberg et al., 1994)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\spdo for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) spdo-RA FBtr0085651  NM_170493   2082   565
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein spdo-PA   FBpp0085013   63.8   565   8.71     NP_733372   AAN14235
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAN14235   AY069737   BI164912   BI231733   BT001576 AAN71331   BT057990   EC211423   EC246757
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IGV5 Q8IMI5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   presumptive embryonic/larval central nervous system   (O'Connor-Giles and Skeath, 2003) embryonic/larval central nervous system   (O'Connor-Giles and Skeath, 2003) presumptive embryonic/larval peripheral nervous system   (O'Connor-Giles and Skeath, 2003) embryonic/larval peripheral nervous system   (O'Connor-Giles and Skeath, 2003) mesoderm   (O'Connor-Giles and Skeath, 2003)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 10 -- 13   embryonic neuroblast   • plasma membrane (O'Connor-Giles and Skeath, 2003) embryonic ganglion mother cell   • plasma membrane (O'Connor-Giles and Skeath, 2003) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
	spdo protein is expressed in all embryonic cells known to undergo asymmetric divisions. (O'Connor-Giles and Skeath, 2003)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0260440    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0260440 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 06-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0260440 expression level Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    632 embryo 04-06hr    2344 embryo 06-08hr    6742 embryo 08-10hr    5038 embryo 10-12hr    2492 embryo 12-14hr    1282 embryo 14-16hr    468 embryo 16-18hr    199 embryo 18-20hr    220 embryo 20-22hr    108 embryo 22-24hr    104 larva L1    56 larva L2    75 larva L3 12hr old    62 larva L3 puffstage 1-2    136 larva L3 puffstage 3-6    256 larva L3 puffstage 7-9    252 white prepupae new    289 white prepupae 12hr    394 white prepupae 24hr    303 pupae 2d postWPP    114 pupae 3d postWPP    45 pupae 4d postWPP    81 adult male 01day    23 adult male 05day    27 adult male 30day    21 adult female 01day    40 adult female 05day    40 adult female 30day    21 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr  (632) embryo 04-06hr  (2344) embryo 06-08hr  (6742) embryo 08-10hr  (5038) embryo 10-12hr  (2492) embryo 12-14hr  (1282) embryo 14-16hr  (468) embryo 16-18hr  (199) embryo 18-20hr  (220) embryo 20-22hr  (108) embryo 22-24hr  104 larva L1    56 larva L2    75 larva L3 12hr old    62 larva L3 puffstage 1-2  (136) larva L3 puffstage 3-6  (256) larva L3 puffstage 7-9  (252) white prepupae new  (289) white prepupae 12hr  (394) white prepupae 24hr  (303) pupae 2d postWPP  (114) pupae 3d postWPP    45 pupae 4d postWPP    81 adult male 01day    23 adult male 05day    27 adult male 30day    21 adult female 01day    40 adult female 05day    40 adult female 30day    21 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    632 embryo 04-06hr  (2344) embryo 06-08hr  (6742) embryo 08-10hr  (5038) embryo 10-12hr  (2492) embryo 12-14hr    1282 embryo 14-16hr    468 embryo 16-18hr    199 embryo 18-20hr    220 embryo 20-22hr    108 embryo 22-24hr    104 larva L1    56 larva L2    75 larva L3 12hr old    62 larva L3 puffstage 1-2    136 larva L3 puffstage 3-6    256 larva L3 puffstage 7-9    252 white prepupae new    289 white prepupae 12hr    394 white prepupae 24hr    303 pupae 2d postWPP    114 pupae 3d postWPP    45 pupae 4d postWPP    81 adult male 01day    23 adult male 05day    27 adult male 30day    21 adult female 01day    40 adult female 05day    40 adult female 30day    21 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    632 embryo 04-06hr    2344 embryo 06-08hr    6742 embryo 08-10hr    5038 embryo 10-12hr    2492 embryo 12-14hr    1282 embryo 14-16hr    468 embryo 16-18hr    199 embryo 18-20hr    220 embryo 20-22hr    108 embryo 22-24hr    104 larva L1    56 larva L2    75 larva L3 12hr old    62 larva L3 puffstage 1-2    136 larva L3 puffstage 3-6    256 larva L3 puffstage 7-9    252 white prepupae new    289 white prepupae 12hr    394 white prepupae 24hr    303 pupae 2d postWPP    114 pupae 3d postWPP    45 pupae 4d postWPP    81 adult male 01day    23 adult male 05day    27 adult male 30day    21 adult female 01day    40 adult female 05day    40 adult female 30day    21 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    632 embryo 04-06hr    2344 embryo 06-08hr    6742 embryo 08-10hr    5038 embryo 10-12hr    2492 embryo 12-14hr    1282 embryo 14-16hr    468 embryo 16-18hr    199 embryo 18-20hr    220 embryo 20-22hr    108 embryo 22-24hr    104 larva L1    56 larva L2    75 larva L3 12hr old    62 larva L3 puffstage 1-2    136 larva L3 puffstage 3-6    256 larva L3 puffstage 7-9    252 white prepupae new    289 white prepupae 12hr    394 white prepupae 24hr    303 pupae 2d postWPP    114 pupae 3d postWPP    45 pupae 4d postWPP    81 adult male 01day    23 adult male 05day    27 adult male 30day    21 adult female 01day    40 adult female 05day    40 adult female 30day    21 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0260440 expression level Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    632 embryo 04-06hr    2344 embryo 06-08hr    6742 embryo 08-10hr    5038 embryo 10-12hr    2492 embryo 12-14hr    1282 embryo 14-16hr    468 embryo 16-18hr    199 embryo 18-20hr    220 embryo 20-22hr    108 embryo 22-24hr    104 larva L1    56 larva L2    75 larva L3 12hr old    62 larva L3 puffstage 1-2    136 larva L3 puffstage 3-6    256 larva L3 puffstage 7-9    252 white prepupae new    289 white prepupae 12hr    394 white prepupae 24hr    303 pupae 2d postWPP    114 pupae 3d postWPP    45 pupae 4d postWPP    81 adult male 01day    23 adult male 05day    27 adult male 30day    21 adult female 01day    40 adult female 05day    40 adult female 30day    21 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr  (632) embryo 04-06hr  (2344) embryo 06-08hr  (6742) embryo 08-10hr  (5038) embryo 10-12hr  (2492) embryo 12-14hr  (1282) embryo 14-16hr  (468) embryo 16-18hr  (199) embryo 18-20hr  (220) embryo 20-22hr  108 embryo 22-24hr  104 larva L1    56 larva L2    75 larva L3 12hr old    62 larva L3 puffstage 1-2  136 larva L3 puffstage 3-6  (256) larva L3 puffstage 7-9  (252) white prepupae new  (289) white prepupae 12hr  (394) white prepupae 24hr  (303) pupae 2d postWPP  114 pupae 3d postWPP    45 pupae 4d postWPP    81 adult male 01day    23 adult male 05day    27 adult male 30day    21 adult female 01day    40 adult female 05day    40 adult female 30day    21 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    632 embryo 04-06hr  2344 embryo 06-08hr  (6742) embryo 08-10hr  (5038) embryo 10-12hr  (2492) embryo 12-14hr    1282 embryo 14-16hr    468 embryo 16-18hr    199 embryo 18-20hr    220 embryo 20-22hr    108 embryo 22-24hr    104 larva L1    56 larva L2    75 larva L3 12hr old    62 larva L3 puffstage 1-2    136 larva L3 puffstage 3-6    256 larva L3 puffstage 7-9    252 white prepupae new    289 white prepupae 12hr    394 white prepupae 24hr    303 pupae 2d postWPP    114 pupae 3d postWPP    45 pupae 4d postWPP    81 adult male 01day    23 adult male 05day    27 adult male 30day    21 adult female 01day    40 adult female 05day    40 adult female 30day    21 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    632 embryo 04-06hr    2344 embryo 06-08hr    6742 embryo 08-10hr    5038 embryo 10-12hr    2492 embryo 12-14hr    1282 embryo 14-16hr    468 embryo 16-18hr    199 embryo 18-20hr    220 embryo 20-22hr    108 embryo 22-24hr    104 larva L1    56 larva L2    75 larva L3 12hr old    62 larva L3 puffstage 1-2    136 larva L3 puffstage 3-6    256 larva L3 puffstage 7-9    252 white prepupae new    289 white prepupae 12hr    394 white prepupae 24hr    303 pupae 2d postWPP    114 pupae 3d postWPP    45 pupae 4d postWPP    81 adult male 01day    23 adult male 05day    27 adult male 30day    21 adult female 01day    40 adult female 05day    40 adult female 30day    21 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    632 embryo 04-06hr    2344 embryo 06-08hr    6742 embryo 08-10hr    5038 embryo 10-12hr    2492 embryo 12-14hr    1282 embryo 14-16hr    468 embryo 16-18hr    199 embryo 18-20hr    220 embryo 20-22hr    108 embryo 22-24hr    104 larva L1    56 larva L2    75 larva L3 12hr old    62 larva L3 puffstage 1-2    136 larva L3 puffstage 3-6    256 larva L3 puffstage 7-9    252 white prepupae new    289 white prepupae 12hr    394 white prepupae 24hr    303 pupae 2d postWPP    114 pupae 3d postWPP    45 pupae 4d postWPP    81 adult male 01day    23 adult male 05day    27 adult male 30day    21 adult female 01day    40 adult female 05day    40 adult female 30day    21 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0260440    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0260440 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0260440 expression level Tissue   Expression Level Larval Central Nervous System    240.375 Larval Midgut    31.3 Larval Hindgut    9.2 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    6.9 Larval Trachea    6.325 Larval Carcass    6.5 Adult Head    8.2 Adult Eye    5.95 Adult Brain    5.9 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    34.9 Adult Hindgut no informative data Adult Malpighian Tubules    9.5 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    4.75 Adult VirginFemale Spermatheca    19.9 Adult InseminatedFemale Spermatheca    18.1 Adult Ovary    6.6 Adult Testis    4.8 Adult Male Accessory Gland    55.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    240.375 Larval Midgut    31.3 Larval Hindgut    9.2 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    6.9 Larval Trachea    6.325 Larval Carcass    6.5 Adult Head    8.2 Adult Eye    5.95 Adult Brain    5.9 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    34.9 Adult Hindgut no informative data Adult Malpighian Tubules    9.5 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    4.75 Adult VirginFemale Spermatheca    19.9 Adult InseminatedFemale Spermatheca    18.1 Adult Ovary    6.6 Adult Testis    4.8 Adult Male Accessory Gland    55.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    240.375 Larval Midgut    31.3 Larval Hindgut    9.2 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    6.9 Larval Trachea    6.325 Larval Carcass    6.5 Adult Head    8.2 Adult Eye    5.95 Adult Brain    5.9 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    34.9 Adult Hindgut no informative data Adult Malpighian Tubules    9.5 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    4.75 Adult VirginFemale Spermatheca    19.9 Adult InseminatedFemale Spermatheca    18.1 Adult Ovary    6.6 Adult Testis    4.8 Adult Male Accessory Gland    55.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    240.375 Larval Midgut    31.3 Larval Hindgut    9.2 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    6.9 Larval Trachea    6.325 Larval Carcass    6.5 Adult Head    8.2 Adult Eye    5.95 Adult Brain    5.9 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    34.9 Adult Hindgut no informative data Adult Malpighian Tubules    9.5 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    4.75 Adult VirginFemale Spermatheca    19.9 Adult InseminatedFemale Spermatheca    18.1 Adult Ovary    6.6 Adult Testis    4.8 Adult Male Accessory Gland    55.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0260440 expression level Tissue   Expression Level Larval Central Nervous System    240.375 Larval Midgut    31.3 Larval Hindgut    9.2 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    6.9 Larval Trachea    6.325 Larval Carcass    6.5 Adult Head    8.2 Adult Eye    5.95 Adult Brain    5.9 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    34.9 Adult Hindgut no informative data Adult Malpighian Tubules    9.5 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    4.75 Adult VirginFemale Spermatheca    19.9 Adult InseminatedFemale Spermatheca    18.1 Adult Ovary    6.6 Adult Testis    4.8 Adult Male Accessory Gland    55.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    240.375 Larval Midgut    31.3 Larval Hindgut    9.2 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    6.9 Larval Trachea    6.325 Larval Carcass    6.5 Adult Head    8.2 Adult Eye    5.95 Adult Brain    5.9 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    34.9 Adult Hindgut no informative data Adult Malpighian Tubules    9.5 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    4.75 Adult VirginFemale Spermatheca    19.9 Adult InseminatedFemale Spermatheca    18.1 Adult Ovary    6.6 Adult Testis    4.8 Adult Male Accessory Gland    55.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    240.375 Larval Midgut    31.3 Larval Hindgut    9.2 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    6.9 Larval Trachea    6.325 Larval Carcass    6.5 Adult Head    8.2 Adult Eye    5.95 Adult Brain    5.9 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    34.9 Adult Hindgut no informative data Adult Malpighian Tubules    9.5 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    4.75 Adult VirginFemale Spermatheca    19.9 Adult InseminatedFemale Spermatheca    18.1 Adult Ovary    6.6 Adult Testis    4.8 Adult Male Accessory Gland    55.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    240.375 Larval Midgut    31.3 Larval Hindgut    9.2 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    6.9 Larval Trachea    6.325 Larval Carcass    6.5 Adult Head    8.2 Adult Eye    5.95 Adult Brain    5.9 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    34.9 Adult Hindgut no informative data Adult Malpighian Tubules    9.5 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    4.75 Adult VirginFemale Spermatheca    19.9 Adult InseminatedFemale Spermatheca    18.1 Adult Ovary    6.6 Adult Testis    4.8 Adult Male Accessory Gland    55.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut     Adult Hindgut no informative data Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    8.2   NA  Eye    5.95   NA  Brain    5.9   240.375  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    no informative data   31.3  Midgut    34.9   9.2  Hindgut    no informative data   no informative data  Malpighian Tubules    9.5   no informative data  Fat Body    no informative data   6.9  Salivary Gland    no informative data   NA  Heart    4.75   6.325  Trachea    NA   NA  VirginFemale Spermatheca    19.9   NA  InseminatedFemale Spermatheca    18.1   NA  Ovary    6.6   NA  Testis    4.8   NA  Male Accessory Gland    55.2   6.5  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0260440
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with spdo3R6) spdoC55 lethal (with spdoC55) spdo3R6 lethal | embryonic stage spdoG104 spdoH7 spdoK433 spdounspecified lethal | embryonic stage | recessive spdoS097002b lethal | recessive spdoC55 spdoK433 spdoS097002b viable, with Scer\GAL4pnr-MD237 spdoGD3130 Other Phenotypes Allele neuroanatomy defective spdoC55 spdoG104 size defective spdoScer\UAS.cOa visible, with Scer\GAL4pnr-MD237 spdoGD3130 Phenotype manifest in Allele abdominal 1 basiconical sensillum dbd & embryonic glial cell spdoG104 spdoK433 abdominal 1 dorsal acute muscle 3 spdoK433 abdominal 1 dorsal bipolar neuron dbp spdoG104 spdoK433 abdominal 1 dorsal oblique muscle 5 spdoK433 abdominal 2 basiconical sensillum dbd & embryonic glial cell spdoG104 spdoK433 abdominal 2 dorsal acute muscle 3 spdoK433 abdominal 2 dorsal bipolar neuron dbp spdoG104 spdoK433 abdominal 2 dorsal oblique muscle 5 spdoK433 abdominal 3 basiconical sensillum dbd & embryonic glial cell spdoG104 spdoK433 abdominal 3 dorsal acute muscle 3 spdoK433 abdominal 3 dorsal bipolar neuron dbp spdoG104 spdoK433 abdominal 3 dorsal oblique muscle 5 spdoK433 abdominal 4 basiconical sensillum dbd & embryonic glial cell spdoG104 spdoK433 abdominal 4 dorsal acute muscle 3 spdoK433 abdominal 4 dorsal bipolar neuron dbp spdoG104 spdoK433 abdominal 4 dorsal oblique muscle 5 spdoK433 abdominal 5 basiconical sensillum dbd & embryonic glial cell spdoG104 spdoK433 abdominal 5 dorsal acute muscle 3 spdoK433 abdominal 5 dorsal bipolar neuron dbp spdoG104 spdoK433 abdominal 5 dorsal oblique muscle 5 spdoK433 abdominal 6 basiconical sensillum dbd & embryonic glial cell spdoG104 spdoK433 abdominal 6 dorsal acute muscle 3 spdoK433 abdominal 6 dorsal bipolar neuron dbp spdoG104 spdoK433 abdominal 6 dorsal oblique muscle 5 spdoK433 abdominal 7 basiconical sensillum dbd & embryonic glial cell spdoG104 spdoK433 abdominal 7 dorsal acute muscle 3 spdoK433 abdominal 7 dorsal bipolar neuron dbp spdoG104 spdoK433 abdominal 7 dorsal oblique muscle 5 spdoK433 abdominal dorsal bipolar neuron dbp | ectopic spdoC55 abdominal dorsal bipolar neuron dbp | embryonic stage | precursor spdounspecified abdominal dorsal bipolar neuron dbp | embryonic stage | supernumerary spdounspecified aCC neuron spdoG104 anterior commissure spdoC55 spdoG104 spdoK433 cardioblast spdoC55 CNS glial cell spdoC55 spdoG104 spdoK433 dMP2 neuron spdoG104 dMP2 neuron | ectopic spdoG104 dorsal multidendritic neuron | ectopic spdoC55 embryonic/larval pericardial cell spdoK433 embryonic heart cardioblast spdoG104 spdounspecified embryonic heart cardioblast | embryonic stage 16 | supernumerary, with Scer\GAL4twi.PG spdoScer\UAS.cOa embryonic pericardial cell spdoG104 embryonic pericardial cell | embryonic stage 16 | supernumerary, with Scer\GAL4twi.PG spdoScer\UAS.cOa embryonic peripheral nervous system & glial cell spdoC55 spdoH7 spdounspecified eo neuron | somatic clone spdoC55 EW1 neuron | ectopic spdoG104 external sensory organ spdoG104 spdoK433 external sensory organ precursor cell | ectopic | third instar larval stage, with Scer\GAL4ptc-559.1 spdoScer\UAS.cOa external sensory organ precursor cell IIb spdoG104 spdoK433 external sensory organ precursor cell IIb | somatic clone | supernumerary spdo3R6 external sensory organ precursor cell IIIb | somatic clone spdo3R6 frontal bristle | somatic clone spdo3R6 GW neuron spdoG104 interommatidial bristle | somatic clone spdo3R6 longitudinal connective spdoC55 spdoG104 spdoK433 spdounspecified macrochaeta & mesothoracic tergum | somatic clone spdoG104 macrochaeta | somatic clone spdoC55 multidendritic neuron spdoG104 spdoK433 multidendritic neuron | precursor spdoG104 spdoK433 neuron | embryonic stage spdoS097002b pCC neuron spdoG104 peripheral nervous system spdoG104 spdoK433 peripheral nervous system precursor cluster spdoH7 spdounspecified peripheral nervous system precursor cluster & neuron | supernumerary spdoH7 spdounspecified posterior commissure spdoC55 spdoG104 spdoK433 presumptive embryonic/larval central nervous system spdoG104 spdoS097002b spdounspecified presumptive embryonic/larval peripheral nervous system spdoC55 RP2 neuron spdoG104 RP2 neuron | supernumerary spdodsRNA.cOa RP2sib neuron spdoG104 scutellar bristle | ectopic, with Scer\GAL4ptc-559.1 spdoScer\UAS.cOa thecogen cell spdoG104 spdoK433 thecogen cell & peripheral nervous system spdoC55 spdoK433 tormogen cell, with Scer\GAL4pnr-MD237 spdoGD3130 trichogen cell | supernumerary, with Scer\GAL4pnr-MD237 spdoGD3130 U neuron spdoG104 spdodsRNA.cOa Usib neuron spdoG104 vMP2 neuron spdoG104 wing, with Scer\GAL4nub-AC-62 spdoScer\UAS.cOa wing margin, with Scer\GAL4nub-AC-62 spdoScer\UAS.cOa wing vein, with Scer\GAL4nub-AC-62 spdoScer\UAS.cOa
Classical Alleles ( 16 )
For All Classical Alleles Show
Allele of spdo Class Mutagen Stocks Known lesion spdoC55 loss of function allele ethyl methanesulfonate 1 Yes spdoG104 loss of function allele ethyl methanesulfonate 1 Yes spdo3R6 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes spdoAB153 0 Yes spdoAC81 0 Yes spdoAC85 0 Yes spdoH7 loss of function allele 0 Yes spdoK433 loss of function allele ethyl methanesulfonate 0 Yes spdoOO3 0 Yes spdoP46 0 Yes spdoS097002b Delta2-3 P-element activity 0 Yes spdounspecified ethyl methanesulfonate 0 -- spdoVV86 0 Yes spdoYY233 0 -- spdoZ143 0 Yes spdoZZ213 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of spdo Class Mutagen Stocks Known lesion spdoGD3130 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes spdoJF01806 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes spdoKK103906 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes spdoScer\UAS.cOa in vitro construct - regulatory fusion 1 Yes spdodsRNA.cOa in vitro construct - RNAi 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6215 (Ryder, 2004.4.26) Df(3R)Exel6216 (Ryder, 2004.4.26, Abrams et al., 2006) Df(3R)tll-g (Dye et al., 1998, Salzberg et al., 1994) Df(3R)ZZ27 (Dye et al., 1998, Park et al., 1998, Skeath, 2004) T(Y;3)R133 (BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3130} NA P{KK103906} NA P{TRiP.JF01806} NA P{UAS-spdo.O} NA heat-shock construct P{HS-tmod.E42} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 16 unique terms )
Terms Based on Experimental Evidence ( 14 terms )
Molecular Function
CV term Evidence References
Notch binding inferred from physical interaction with N (O'Connor-Giles and Skeath, 2003) protein binding inferred from physical interaction with numb (O'Connor-Giles and Skeath, 2003)
Biological Process
CV term Evidence References
asymmetric cell division inferred from direct assay (Babaoglan et al., 2009) inferred from mutant phenotype (O'Connor-Giles and Skeath, 2003) heart morphogenesis inferred from mutant phenotype (Albrecht et al., 2006) negative regulation of Notch signaling pathway inferred from mutant phenotype (Babaoglan et al., 2009) Notch signaling pathway inferred from genetic interaction with N AND inferred from physical interaction with N (O'Connor-Giles and Skeath, 2003) sensory organ development inferred from mutant phenotype (Roegiers et al., 2005) sensory organ precursor cell division inferred from mutant phenotype (Babaoglan et al., 2009, Hutterer and Knoblich, 2005)
Cellular Component
CV term Evidence References
cortical cytoskeleton inferred from direct assay (Roegiers et al., 2005) cytoplasm inferred from direct assay (O'Connor-Giles and Skeath, 2003) colocalizes_with cytoplasmic vesicle inferred from direct assay (Jafar-Nejad et al., 2005) early endosome inferred from direct assay (Hutterer and Knoblich, 2005) late endosome inferred from direct assay (Hutterer and Knoblich, 2005) plasma membrane inferred from direct assay (O'Connor-Giles and Skeath, 2003, Roegiers et al., 2005, Hutterer and Knoblich, 2005) colocalizes_with plasma membrane inferred from direct assay (Jafar-Nejad et al., 2005)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
peripheral nervous system development non-traceable author statement (Prokopenko et al., 2000) traceable author statement (Salzberg et al., 1994)
Cellular Component
CV term Evidence References
integral to membrane inferred from sequence or structural similarity (O'Connor-Giles and Skeath, 2003)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions spdo allele Gene References spdoG104 numb (Lundell et al., 2003) spdoH7 numb (Dye et al., 1998) tmod (Dye et al., 1998) unspecified numb (Skeath and Doe, 1998)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 76878 DroID - A comprehensive database of gene and protein interactions. • FBgn0260440 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 318559
Orthologs
Genome-wide drosophilid orthologs	Dgri\GH14100 Dmoj\GI24859 Dper\GL13461 Dvir\GJ24501 Dyak\GE10880
Curated drosophilid orthologs
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AGAP002689-PA Anopheles gambiae (mosquito) BGIBMGA009789-PA Bombyx mori (silk worm) CPIJ002901 Culex pipens (mosquito) PHUM006464-PA Pediculus humanus (human body louse) XP_975069.1 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0228714 FBgn0211581 FBgn0075960 FBgn0151067 FBgn0147579 FBgn0121576 CPIJ002901 BGIBMGA009789 ACYPI45608 AGAP002689 PHUM065540 GLEAN_10201
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	9934 w*; P{UAS-spdo.O}G14 31227 y1 v1; P{TRiP.JF01806}attP2 9933 y1 w*; P{neoFRT}82B es spdoG104/TM3, Sb1 4374 y1 w1; P{lacW}64A th1 st1 cu1 es spdoC55 ca1/TM6B, P{iab-2(1.7)lacZ}6B, Tb+
VDRC	v104092 P{KK103906}VIE-260B v6858 w1118 P{GD3130}v6858 v6856 w1118; P{GD3130}v6856/TM3
Genomic Clones ( 1 )
	BACR48G16 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 6 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP05501 RE23355
Other clones	FI04474
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE04681
Other clones	55734 66330
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0260440 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 318559
Antibody Information
	polyclonal (Hutterer and Knoblich, 2005, O'Connor-Giles and Skeath, 2003)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG31020 BcDNA:RE23355 (FlyBase, 1996-) Source for merge of: spdo CG31020 (O'Connor-Giles and Skeath, 2003)
Additional comments	The "spdo" complementation group corresponds to the CG31020 annotation and not to "tmod" as previously reported in FBrf0102830; molecular lesions in the CG31020 annotation have been identified in 12 spdo alleles, RNAi against CG31020 results in a central nervous system (CNS) phenotype essentially identical to that of spdo mutants and expression of CG31020 throughout the CNS of spdo mutant embryos results in complete to near-complete rescue of the spdo CNS phenotype. (O'Connor-Giles and Skeath, 2003) FlyBase curator comment: FBrf0102830 states that the "spdo" complementation group corresponds to the "tmod, tropomodulin" gene. However, FBrf0162056 shows that this was an error and the spdo complementation group actually corresponds to the CG31020 annotation. (Dye et al., 1998) The "spdo" complementation group corresponds to the CG31020 annotation and not to the CG1539 annotation. It was reported in FBrf0102830 that "spdo" corresponds to the "tmod, tropomodulin" gene (the CG1539 annotation). However, this was subsequently shown to be an error. FBrf0162056 shows that the "spdo" complementation group corresponds instead to the CG31020 annotation. (FlyBase, 1996-) Source for merge of CG31020 BcDNA:RE23355 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
	New annotation (CG31020) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) numb and spdo mediate the asymmetric divisions in the developing heart which result in the production of an odd-expressing pericardial cell and a cardioblast. (Ward and Skeath, 2000) Two EMS induced alleles have been identified in a screen for mutations affecting commissure formation in the CNS of the embryo. (Hummel et al., 1999) Mutations in spdo affect the asymmetric cell division of the embryonic PNS SOPIIb. Rather than a neuron and a glial cell, two neurons are produced. spdo is also required in several other PNS lineages. spdo is epistatic to numb. (Dye et al., 1998) spdo and N act in opposition to numb to distinguish sibling neuron fates in the CNS. (Skeath and Doe, 1998) The numb mutant phenotype is extremely sensitive to the dosage of spdo. (Skeath and Doe, 1998) sanpodo is Korean for mountain grape. (Lee et al., 1995) spdo is required to define glial versus neuronal cell identity. (Lee et al., 1995) Mutation in spdo affects the neuronal lineage, causes transformation of support cells into neurons. (Salzberg et al., 1994) "sanpodo" is Korean for mountain grapes. (Salzberg et al., 1994) spdo is required for PNS development in the embryo. (Salzberg et al., 1994)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_170493 RefSeq (Proteins) • NP_733372 DDBJ / EMBL / GenBank • AAN14235 AAN71331 BI231733 BT001576 Entrez Gene - A searchable database of RefSeq genes. • 318559 UniProtKB/TrEMBL • Q8IGV5 Q8IMI5
Other Crossreferences
Linkouts
	BioGRID - A database of protein and genetic interactions • 76878 DroID - A comprehensive database of gene and protein interactions. • FBgn0260440 DRSC - Results from RNAi screens. • FBgn0260440 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0260440 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0260440 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 318559 InParanoid A subset of ortholog calls from InParanoid. • AGAP002689-PA Anopheles gambiae (mosquito) BGIBMGA009789-PA Bombyx mori (silk worm) CPIJ002901 Culex pipens (mosquito) PHUM006464-PA Pediculus humanus (human body louse) XP_975069.1 Tribolium castaneum (red flour beetle) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /cytoskel/sanpdo1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 318559 modMine - Data generated by the modENCODE project. • FBgn0260440 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0228714 FBgn0211581 FBgn0075960 FBgn0151067 FBgn0147579 FBgn0121576 CPIJ002901 BGIBMGA009789 ACYPI45608 AGAP002689 PHUM065540 GLEAN_10201
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	0970/02 (Deak et al., 1997) BcDNA:RE23355   CG31020 (Bellen, 2005.1.25, Skeath, 2004, O'Connor-Giles and Skeath, 2003, FlyBase, 1996-, Abrams et al., 2006, Keleman et al., 2009.8.5, Ni et al., 2008, Aerts et al., 2010) spdo (Monastirioti et al., 2010, Wheeler and Crews, 2007, Skeath, 2007.3.20, Karcavich and Doe, 2005, Jafar-Nejad, 2005, Babaoglan et al., 2008, Jafar-Nejad et al., 2005, Wheeler et al., 2008, Tran and Doe, 2008, O'Connor-Giles and Skeath, 2003, Garces and Thor, 2006, Babaoglan et al., 2009, Rouault et al., 2010, Losada-Pérez et al., 2010, Aerts et al., 2010, Wasbrough et al., 2010, Benhra et al., 2011) Spdo (Benhra et al., 2010, Reed et al., 2008)
Name Synonym	sanpodo (Karcavich and Doe, 2005, Albrecht et al., 2006, Roegiers et al., 2005, Wheeler et al., 2008, O'Connor-Giles and Skeath, 2003, Mok et al., 2005, Hutterer and Knoblich, 2005, Babaoglan et al., 2009, Lacin et al., 2009, Mummery-Widmer et al., 2009, Cohen et al., 2010, Losada-Pérez et al., 2010, Manh et al., 2005) Sanpodo (Roegiers et al., 2007, Polo and Di, 2006, Wheeler et al., 2006, Somers and Chia, 2005, Wang et al., 2006, Benhra et al., 2010, Babaoglan et al., 2008, Natarajan and Skeath, 2008, Yamamoto et al., 2008, Roegiers et al., 2005, Tong et al., 2010, Benhra et al., 2011) tropomodulin (Manh et al., 2005)
Secondary FlyBase IDs
	FBgn0010731 FBgn0011716 FBgn0039785 FBgn0039786 FBgn0051020 FBgn0064900
References ( 97 )
Generate a list of	All references relating to this gene ( 97 )
List References by type	Research paper  ( 46 ) Supplementary material  ( 3 ) Review  ( 12 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 24 ) FlyBase analysis  ( 2 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 )
Recent research papers ( 9 )
	Benhra et al., 2011, Curr. Biol. 21(1): 87--95 AP-1 Controls the Trafficking of Notch and Sanpodo toward E-Cadherin Junctions in Sensory Organ Precursors. [FBrf0212697] Aerts et al., 2010, PLoS Biol. 8(7): e1000435 Robust Target Gene Discovery through Transcriptome Perturbations and Genome-Wide Enhancer Predictions in Drosophila Uncovers a Regulatory Basis for Sensory Specification. [FBrf0211419] Benhra et al., 2010, Mol. Biol. Cell 21(12): 2078--2086 Neuralized promotes Basal to apical transcytosis of delta in epithelial cells. [FBrf0211002] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Cohen et al., 2010, Dev. Cell 19(1): 78--89 Dynamic Filopodia Transmit Intermittent Delta-Notch Signaling to Drive Pattern Refinement during Lateral Inhibition. [FBrf0211296] Losada-Pérez et al., 2010, Mech. Dev. 127(9-12): 458--471 Lineage-unrelated neurons generated in different temporal windows and expressing different combinatorial codes can converge in the activation of the same terminal differentiation gene. [FBrf0212045] Monastirioti et al., 2010, Development 137(2): 191--201 Drosophila Hey is a target of Notch in asymmetric divisions during embryonic and larval neurogenesis. [FBrf0209592] Rouault et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(33): 14615--14620 Genome-wide identification of cis-regulatory motifs and modules underlying gene coregulation using statistics and phylogeny. [FBrf0211646] Tong et al., 2010, Mol. Biol. Cell 21(5): 802--810 Numb independently antagonizes sanpodo membrane targeting and notch signaling in Drosophila sensory organ precursor cells. [FBrf0210112] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...