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Gene Dmel\rhea

General Information
Symbol	Dmel\rhea	Species	D. melanogaster
Name	rhea	Annotation symbol	CG6831
Feature type	protein_coding_gene	FlyBase ID	FBgn0260442
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	talin
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	66D6-66D7	Sequence location	3L:8,538,101..8,567,509 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene rhea is referred to in FlyBase by the symbol Dmel\rhea (CG6831, FBgn0260442). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; integrin binding. There is experimental evidence that it is involved in the biological process: regulation of cell shape; apposition of dorsal and ventral imaginal disc-derived wing surfaces; trachea morphogenesis; larval somatic muscle development; cell adhesion; terminal branching, open tracheal system; maintenance of epithelial integrity, open tracheal system; muscle attachment; negative regulation of transcription, DNA-dependent; phagocytosis, engulfment. 40 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/larval midgut primordium; embryonic proventriculus; embryonic/larval tracheal system; terminal tracheal cell; muscle attachment site; gastric caecum primordium; embryonic/larval somatic muscle. It has 8 annotated transcripts and 8 annotated polypeptides. Protein features are: Band 4.1 domain; FERM central domain; FERM conserved site; FERM domain; FERM, N-terminal; FERM/acyl-CoA-binding protein, 3-helical bundle; I/LWEQ domain; Insulin receptor substrate-1, PTB; Pleckstrin homology-like domain; Talin, central; Vinculin-binding site-containing domain; Vinculin/alpha-catenin. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 12-24 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult salivary gland, larval trachea, adult female reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult fat body, virgin spermatheca, adult male reproductive system. Comments on Affy2 ProbeSet: ProbeSet 1628141_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of rhea. Gene sequence location is 3L:8538101..8567509.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Controlled Vocabulary Terms border follicle cell migration Alleles rhea[IBS2.Scer\UAS.T:Avic\GFP-m6] rhea[R367A.IBS1.L2103A.I2104A.IBS2.Ubi-p63E.T:Avic\GFP-m6] rhea[R367A.Ubi-p63E.T:Avic\GFP-EGFP] rhea[L2103A.I2104A.IBS2.Scer\UAS.T:Avic\GFP-m6] rhea[R367A.Scer\UAS.IBS1.T:Avic\GFP] rhea[K2094D.S2098D.IBS2.Ubi-p63E.T:Avic\GFP-m6] rhea[L2103A.I2104A.IBS2.Ubi-p63E.T:Avic\GFP-m6] rhea[Scer\UAS.IBS1.T:Avic\GFP] rhea[R376A.H.Scer\UAS.T:Avic\GFP] rhea[K2094D.S2098D.IBS2.Scer\UAS.T:Avic\GFP-m6] Transgenic Constructs P{UAS-GFP-rhea.IBS1.R367A.IBS2.LI} P{UAS-GFP-rhea.IBS2.LI} P{UAS-rhea.IBS1-GFP} P{UAS-GFP-rhea.IBS2} P{UAS-GFP-rhea.IBS1.R367A} P{UAS-rhea.IBS1-GFP.R367A} P{UAS-talin.H.R376A.GFP} P{UAS-GFP-rhea.IBS2.KS}
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 66D6-66D7   Limits computationally determined from genome sequence between P{lacW}foij8E8 and P{PZ}SrpRβrK561&P{lacW}l(3)j5B6j5B6
Experimentally Determined Cytological Location
Cytogenetic map Notes References   rhea is not located at 75A-75C, but is elsewhere on 3L.   (Fristrom, 1997.8.6)
Experimentally Determined Recombination Data
Location	3- (Prout et al., 1997, Ghabrial et al., 2011)
Left of (cM)	h (Ghabrial et al., 2011)
Right of (cM)	ru (Ghabrial et al., 2011)
Notes	Located on 3L. (Prout et al., 1997)
Gene Model & Products
Please see the GBrowse view of Dmel\rhea for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46 Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) rhea-RB FBtr0305210  NM_001259745   9584   2836 rhea-RC FBtr0305211  NM_001259746   7261   2169 rhea-RD FBtr0305212  NM_001259747   7373   2169 rhea-RE FBtr0333105  NM_001274657   9937   2836 rhea-RF FBtr0333106  NM_139981   9409   2836 rhea-RG FBtr0333107  NM_001274658   9521   2815 rhea-RH FBtr0333108  NM_001274659   9265   2689 rhea-RI FBtr0333109  NM_001274660   9722   513
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein rhea-PB   FBpp0293740   307.0   2836   6.14     NP_001246674   AFH04345 rhea-PC   FBpp0293741   235.3   2169   5.87     NP_001246675   AFH04346 rhea-PD   FBpp0293742   235.3   2169   5.87     NP_001246676   AFH04347 rhea-PE   FBpp0305317   307.0   2836   6.14     NP_001261586   AGB94281 rhea-PF   FBpp0305318   307.0   2836   6.14     NP_648238   AAF50399 rhea-PG   FBpp0305319   304.7   2815   6.20     NP_001261587   AGB94282 rhea-PH   FBpp0305320   291.5   2689   5.95     NP_001261588   AGB94283 rhea-PI   FBpp0305321   58.8   513   7.04     NP_001261589   AGB94284
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Vinculin/alpha-catenin (IPR006077) I/LWEQ domain (IPR002558) Vinculin-binding site-containing domain (IPR015009) FERM central domain (IPR019748) Talin, central (IPR015224) Insulin receptor substrate-1, PTB (IPR002404) FERM conserved site (IPR019747) Pleckstrin homology-like domain (IPR011993) FERM/acyl-CoA-binding protein, 3-helical bundle (IPR014352) Band 4.1 domain (IPR019749) FERM, N-terminal (IPR018979) FERM domain (IPR000299)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA540353   AA698127   AE014296 AAF50399   AF299248 AAG22814   AE014296 AFH04345   AE014296 AFH04346   AE014296 AFH04347   AE014296 AGB94281   AE014296 AGB94282   AE014296 AGB94283   AE014296 AGB94284   AI256966   AI402787   AI406036   AI513353   AI516176   AI518486   AI541975   AI544075   AY052129 AAK93553   BE975243   BF487732   BF505784   BG633198   BG637672   BG637965   BG638206   BG639184   BT100216   CK132112   CO153818   CO156082   CO177947   CO181876   CO189324   CO190287   CO194739   CO196348   CO264796   CO270732   CO273518   CO275640   CO276725   CO281151   CO281625   CO284127   CO284971   CO285407   CO299986   CO300537   CO303814   CO304588   CO305134   CO310262   CO311565   CO317453   CO318015   CO325835   CO326332   CO337449   CO339219   CO342901   CO344301   CO344729   CZ466353   CZ466360   EC057141   EC061151   EC061585   EC062463   EC062620   EC064860   EC072738   EC077122   EC079673   EC083087   EC084695   EC085214   EC086842   EC087522   EC198281   EC198514   EC199631   EC200186   EC202276   EC202590   EC208664   EC209373   EC211218   EC214590   EC218566   EC222553   EC222574   EC228955   EC233935   EC236428   EC250041   EC252796   EC255084   EC255497   EC257948   EC258415   EC261180   EC261556
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VSL8 Q960C2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 6   organism | ubiquitous   (Brown et al., 2002) embryonic stage 12   ventral nervous system   (Brown et al., 2002) embryonic stage 16   ventral nervous system   (Brown et al., 2002) embryonic/larval midgut primordium   (Brown et al., 2002) muscle attachment site   (Brown et al., 2002)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 6     • cytoplasm (Brown et al., 2002) embryonic stage 12   anterior midgut primordium & posterior midgut primordium   • plasma membrane (Brown et al., 2002) embryonic stage 16   muscle attachment site   • plasma membrane & adherens junction (Brown et al., 2002) third instar larval stage   wing disc | restricted   (Brown et al., 2002) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011) western blot Stage Tissue/Position (including subcellular localization) Reference   S2 cell-line   (Wheeler and Hynes, 2001)
Additional Descriptive Data
	The rhea protein was detected in the cytoplasm of early cellularized embryos. Subsequently, rhea protein concentrated at the membrane of migrating midgut primordial cells and then at muscle attachment sites, specifically at hemi-adherens junctions. In wing imaginal discs the rhea protein localized to focal adhesion like structures at the basal surface. (Brown et al., 2002)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult salivary gland, larval trachea, adult female reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult fat body, virgin spermatheca, adult male reproductive system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1456.025 Larval Midgut    1054.7 Larval Hindgut    1321.2 Larval Malpighian Tubules    965.3 Larval Fat Body    448 Larval Salivary Gland    889.8 Larval Trachea    1008.775 Larval Carcass    1615.35 Adult Head    540.2 Adult Eye    690.575 Adult Brain    685.3 Adult Thoracic-Abdominal Ganglion    1511.6 Adult Crop    1821.3 Adult Midgut    603.1 Adult Hindgut    864.8 Adult Malpighian Tubules    626.5 Adult Fat Body    431.5 Adult Salivary Gland    896 Adult Heart    1206.925 Adult VirginFemale Spermatheca    384.2 Adult InseminatedFemale Spermatheca    604 Adult Ovary    511.1 Adult Testis    206.9 Adult Male Accessory Gland    473.1 Adult Carcass    670.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1456.025) Larval Midgut  (1054.7) Larval Hindgut  (1321.2) Larval Malpighian Tubules  (965.3) Larval Fat Body    448 Larval Salivary Gland  (889.8) Larval Trachea  (1008.775) Larval Carcass  (1615.35) Adult Head  (540.2) Adult Eye  (690.575) Adult Brain  (685.3) Adult Thoracic-Abdominal Ganglion  (1511.6) Adult Crop  (1821.3) Adult Midgut  (603.1) Adult Hindgut  (864.8) Adult Malpighian Tubules  (626.5) Adult Fat Body    431.5 Adult Salivary Gland  (896) Adult Heart  (1206.925) Adult VirginFemale Spermatheca    384.2 Adult InseminatedFemale Spermatheca  (604) Adult Ovary  511.1 Adult Testis    206.9 Adult Male Accessory Gland    473.1 Adult Carcass  (670.7) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1456.025) Larval Midgut  1054.7 Larval Hindgut  (1321.2) Larval Malpighian Tubules    965.3 Larval Fat Body    448 Larval Salivary Gland    889.8 Larval Trachea  1008.775 Larval Carcass  (1615.35) Adult Head    540.2 Adult Eye    690.575 Adult Brain    685.3 Adult Thoracic-Abdominal Ganglion  (1511.6) Adult Crop  (1821.3) Adult Midgut    603.1 Adult Hindgut    864.8 Adult Malpighian Tubules    626.5 Adult Fat Body    431.5 Adult Salivary Gland    896 Adult Heart  (1206.925) Adult VirginFemale Spermatheca    384.2 Adult InseminatedFemale Spermatheca    604 Adult Ovary    511.1 Adult Testis    206.9 Adult Male Accessory Gland    473.1 Adult Carcass    670.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1456.025 Larval Midgut    1054.7 Larval Hindgut    1321.2 Larval Malpighian Tubules    965.3 Larval Fat Body    448 Larval Salivary Gland    889.8 Larval Trachea    1008.775 Larval Carcass    1615.35 Adult Head    540.2 Adult Eye    690.575 Adult Brain    685.3 Adult Thoracic-Abdominal Ganglion    1511.6 Adult Crop    1821.3 Adult Midgut    603.1 Adult Hindgut    864.8 Adult Malpighian Tubules    626.5 Adult Fat Body    431.5 Adult Salivary Gland    896 Adult Heart    1206.925 Adult VirginFemale Spermatheca    384.2 Adult InseminatedFemale Spermatheca    604 Adult Ovary    511.1 Adult Testis    206.9 Adult Male Accessory Gland    473.1 Adult Carcass    670.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1456.025 Larval Midgut    1054.7 Larval Hindgut    1321.2 Larval Malpighian Tubules    965.3 Larval Fat Body    448 Larval Salivary Gland    889.8 Larval Trachea    1008.775 Larval Carcass    1615.35 Adult Head    540.2 Adult Eye    690.575 Adult Brain    685.3 Adult Thoracic-Abdominal Ganglion    1511.6 Adult Crop    1821.3 Adult Midgut    603.1 Adult Hindgut    864.8 Adult Malpighian Tubules    626.5 Adult Fat Body    431.5 Adult Salivary Gland    896 Adult Heart    1206.925 Adult VirginFemale Spermatheca    384.2 Adult InseminatedFemale Spermatheca    604 Adult Ovary    511.1 Adult Testis    206.9 Adult Male Accessory Gland    473.1 Adult Carcass    670.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1456.025) Larval Midgut  (1054.7) Larval Hindgut  (1321.2) Larval Malpighian Tubules  (965.3) Larval Fat Body    448 Larval Salivary Gland  (889.8) Larval Trachea  (1008.775) Larval Carcass  (1615.35) Adult Head  540.2 Adult Eye  690.575 Adult Brain  685.3 Adult Thoracic-Abdominal Ganglion  (1511.6) Adult Crop  (1821.3) Adult Midgut  603.1 Adult Hindgut  (864.8) Adult Malpighian Tubules  626.5 Adult Fat Body    431.5 Adult Salivary Gland  (896) Adult Heart  (1206.925) Adult VirginFemale Spermatheca    384.2 Adult InseminatedFemale Spermatheca  604 Adult Ovary  511.1 Adult Testis    206.9 Adult Male Accessory Gland    473.1 Adult Carcass  670.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1456.025 Larval Midgut  1054.7 Larval Hindgut  1321.2 Larval Malpighian Tubules    965.3 Larval Fat Body    448 Larval Salivary Gland    889.8 Larval Trachea  1008.775 Larval Carcass  1615.35 Adult Head    540.2 Adult Eye    690.575 Adult Brain    685.3 Adult Thoracic-Abdominal Ganglion  1511.6 Adult Crop  (1821.3) Adult Midgut    603.1 Adult Hindgut    864.8 Adult Malpighian Tubules    626.5 Adult Fat Body    431.5 Adult Salivary Gland    896 Adult Heart  1206.925 Adult VirginFemale Spermatheca    384.2 Adult InseminatedFemale Spermatheca    604 Adult Ovary    511.1 Adult Testis    206.9 Adult Male Accessory Gland    473.1 Adult Carcass    670.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1456.025 Larval Midgut    1054.7 Larval Hindgut    1321.2 Larval Malpighian Tubules    965.3 Larval Fat Body    448 Larval Salivary Gland    889.8 Larval Trachea    1008.775 Larval Carcass    1615.35 Adult Head    540.2 Adult Eye    690.575 Adult Brain    685.3 Adult Thoracic-Abdominal Ganglion    1511.6 Adult Crop    1821.3 Adult Midgut    603.1 Adult Hindgut    864.8 Adult Malpighian Tubules    626.5 Adult Fat Body    431.5 Adult Salivary Gland    896 Adult Heart    1206.925 Adult VirginFemale Spermatheca    384.2 Adult InseminatedFemale Spermatheca    604 Adult Ovary    511.1 Adult Testis    206.9 Adult Male Accessory Gland    473.1 Adult Carcass    670.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    540.2   NA  Eye    690.575   NA  Brain    685.3   1456.025  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1511.6   NA  Crop    1821.3   1054.7  Midgut    603.1   1321.2  Hindgut    864.8   965.3  Malpighian Tubules    626.5   448  Fat Body    431.5   889.8  Salivary Gland    896   NA  Heart    1206.925   1008.775  Trachea    NA   NA  VirginFemale Spermatheca    384.2   NA  InseminatedFemale Spermatheca    604   NA  Ovary    511.1   NA  Testis    206.9   NA  Male Accessory Gland    473.1   1615.35  Carcass    670.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    61 central nervous system, pupae P8    28 head, virgin 1-day female    28 head, virgin 4-day female    28 head, virgin 20-day female    23 head, mated 1-day female    24 head, mated 4-day female    19 head, mated 20-day female    20 head, mated 1-day male    44 head, mated 4-day male    29 head, mated 20-day male    35 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    25 digestive system, larvae L3 wandering    39 digestive system, 1-day adult    10 digestive system, 4-day adult    14 digestive system, 20-day adult    16 fat body, larvae L3 wandering    10 fat body, white prepupae    15 fat body, pupae P8    16 carcass, larvae L3 wandering    39 carcass, 1-day adult    40 carcass, 4-day adult    30 carcass, 20-day adult    27 ovary, virgin 4-day female    23 ovary, mated 4-day female    27 testis, mated 4-day male    13 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3  (61) central nervous system, pupae P8  (28) head, virgin 1-day female  (28) head, virgin 4-day female  (28) head, virgin 20-day female    23 head, mated 1-day female    24 head, mated 4-day female    19 head, mated 20-day female    20 head, mated 1-day male  (44) head, mated 4-day male  (29) head, mated 20-day male  (35) salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    25 digestive system, larvae L3 wandering  (39) digestive system, 1-day adult    10 digestive system, 4-day adult    14 digestive system, 20-day adult    16 fat body, larvae L3 wandering    10 fat body, white prepupae    15 fat body, pupae P8    16 carcass, larvae L3 wandering  (39) carcass, 1-day adult  (40) carcass, 4-day adult  (30) carcass, 20-day adult  (27) ovary, virgin 4-day female    23 ovary, mated 4-day female  (27) testis, mated 4-day male    13 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    61 central nervous system, pupae P8    28 head, virgin 1-day female    28 head, virgin 4-day female    28 head, virgin 20-day female    23 head, mated 1-day female    24 head, mated 4-day female    19 head, mated 20-day female    20 head, mated 1-day male    44 head, mated 4-day male    29 head, mated 20-day male    35 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    25 digestive system, larvae L3 wandering    39 digestive system, 1-day adult    10 digestive system, 4-day adult    14 digestive system, 20-day adult    16 fat body, larvae L3 wandering    10 fat body, white prepupae    15 fat body, pupae P8    16 carcass, larvae L3 wandering    39 carcass, 1-day adult    40 carcass, 4-day adult    30 carcass, 20-day adult    27 ovary, virgin 4-day female    23 ovary, mated 4-day female    27 testis, mated 4-day male    13 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    61 central nervous system, pupae P8    28 head, virgin 1-day female    28 head, virgin 4-day female    28 head, virgin 20-day female    23 head, mated 1-day female    24 head, mated 4-day female    19 head, mated 20-day female    20 head, mated 1-day male    44 head, mated 4-day male    29 head, mated 20-day male    35 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    25 digestive system, larvae L3 wandering    39 digestive system, 1-day adult    10 digestive system, 4-day adult    14 digestive system, 20-day adult    16 fat body, larvae L3 wandering    10 fat body, white prepupae    15 fat body, pupae P8    16 carcass, larvae L3 wandering    39 carcass, 1-day adult    40 carcass, 4-day adult    30 carcass, 20-day adult    27 ovary, virgin 4-day female    23 ovary, mated 4-day female    27 testis, mated 4-day male    13 accessory gland, mated 4-day male    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    61 central nervous system, pupae P8    28 head, virgin 1-day female    28 head, virgin 4-day female    28 head, virgin 20-day female    23 head, mated 1-day female    24 head, mated 4-day female    19 head, mated 20-day female    20 head, mated 1-day male    44 head, mated 4-day male    29 head, mated 20-day male    35 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    25 digestive system, larvae L3 wandering    39 digestive system, 1-day adult    10 digestive system, 4-day adult    14 digestive system, 20-day adult    16 fat body, larvae L3 wandering    10 fat body, white prepupae    15 fat body, pupae P8    16 carcass, larvae L3 wandering    39 carcass, 1-day adult    40 carcass, 4-day adult    30 carcass, 20-day adult    27 ovary, virgin 4-day female    23 ovary, mated 4-day female    27 testis, mated 4-day male    13 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3  (61) central nervous system, pupae P8  28 head, virgin 1-day female  28 head, virgin 4-day female  28 head, virgin 20-day female    23 head, mated 1-day female    24 head, mated 4-day female    19 head, mated 20-day female    20 head, mated 1-day male  (44) head, mated 4-day male  29 head, mated 20-day male  (35) salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    25 digestive system, larvae L3 wandering  (39) digestive system, 1-day adult    10 digestive system, 4-day adult    14 digestive system, 20-day adult    16 fat body, larvae L3 wandering    10 fat body, white prepupae    15 fat body, pupae P8    16 carcass, larvae L3 wandering  (39) carcass, 1-day adult  (40) carcass, 4-day adult  30 carcass, 20-day adult  27 ovary, virgin 4-day female    23 ovary, mated 4-day female  27 testis, mated 4-day male    13 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    61 central nervous system, pupae P8    28 head, virgin 1-day female    28 head, virgin 4-day female    28 head, virgin 20-day female    23 head, mated 1-day female    24 head, mated 4-day female    19 head, mated 20-day female    20 head, mated 1-day male    44 head, mated 4-day male    29 head, mated 20-day male    35 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    25 digestive system, larvae L3 wandering    39 digestive system, 1-day adult    10 digestive system, 4-day adult    14 digestive system, 20-day adult    16 fat body, larvae L3 wandering    10 fat body, white prepupae    15 fat body, pupae P8    16 carcass, larvae L3 wandering    39 carcass, 1-day adult    40 carcass, 4-day adult    30 carcass, 20-day adult    27 ovary, virgin 4-day female    23 ovary, mated 4-day female    27 testis, mated 4-day male    13 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    61 central nervous system, pupae P8    28 head, virgin 1-day female    28 head, virgin 4-day female    28 head, virgin 20-day female    23 head, mated 1-day female    24 head, mated 4-day female    19 head, mated 20-day female    20 head, mated 1-day male    44 head, mated 4-day male    29 head, mated 20-day male    35 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    25 digestive system, larvae L3 wandering    39 digestive system, 1-day adult    10 digestive system, 4-day adult    14 digestive system, 20-day adult    16 fat body, larvae L3 wandering    10 fat body, white prepupae    15 fat body, pupae P8    16 carcass, larvae L3 wandering    39 carcass, 1-day adult    40 carcass, 4-day adult    30 carcass, 20-day adult    27 ovary, virgin 4-day female    23 ovary, mated 4-day female    27 testis, mated 4-day male    13 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 12-24 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    39 embryo 04-06hr    39 embryo 06-08hr    57 embryo 08-10hr    65 embryo 10-12hr    84 embryo 12-14hr    109 embryo 14-16hr    143 embryo 16-18hr    119 embryo 18-20hr    116 embryo 20-22hr    87 embryo 22-24hr    87 larva L1    50 larva L2    32 larva L3 12hr old    29 larva L3 puffstage 1-2    23 larva L3 puffstage 3-6    39 larva L3 puffstage 7-9    44 white prepupae new    49 white prepupae 12hr    46 white prepupae 24hr    45 pupae 2d postWPP    32 pupae 3d postWPP    43 pupae 4d postWPP    39 adult male 01day    41 adult male 05day    44 adult male 30day    46 adult female 01day    36 adult female 05day    27 adult female 30day    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (27) embryo 02-04hr  (39) embryo 04-06hr  (39) embryo 06-08hr  (57) embryo 08-10hr  (65) embryo 10-12hr  (84) embryo 12-14hr  (109) embryo 14-16hr  (143) embryo 16-18hr  (119) embryo 18-20hr  (116) embryo 20-22hr  (87) embryo 22-24hr  (87) larva L1  (50) larva L2  (32) larva L3 12hr old  (29) larva L3 puffstage 1-2    23 larva L3 puffstage 3-6  (39) larva L3 puffstage 7-9  (44) white prepupae new  (49) white prepupae 12hr  (46) white prepupae 24hr  (45) pupae 2d postWPP  (32) pupae 3d postWPP  (43) pupae 4d postWPP  (39) adult male 01day  (41) adult male 05day  (44) adult male 30day  (46) adult female 01day  (36) adult female 05day  (27) adult female 30day  (28) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    39 embryo 04-06hr    39 embryo 06-08hr    57 embryo 08-10hr    65 embryo 10-12hr    84 embryo 12-14hr  (109) embryo 14-16hr  (143) embryo 16-18hr  (119) embryo 18-20hr  (116) embryo 20-22hr    87 embryo 22-24hr    87 larva L1    50 larva L2    32 larva L3 12hr old    29 larva L3 puffstage 1-2    23 larva L3 puffstage 3-6    39 larva L3 puffstage 7-9    44 white prepupae new    49 white prepupae 12hr    46 white prepupae 24hr    45 pupae 2d postWPP    32 pupae 3d postWPP    43 pupae 4d postWPP    39 adult male 01day    41 adult male 05day    44 adult male 30day    46 adult female 01day    36 adult female 05day    27 adult female 30day    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    39 embryo 04-06hr    39 embryo 06-08hr    57 embryo 08-10hr    65 embryo 10-12hr    84 embryo 12-14hr    109 embryo 14-16hr    143 embryo 16-18hr    119 embryo 18-20hr    116 embryo 20-22hr    87 embryo 22-24hr    87 larva L1    50 larva L2    32 larva L3 12hr old    29 larva L3 puffstage 1-2    23 larva L3 puffstage 3-6    39 larva L3 puffstage 7-9    44 white prepupae new    49 white prepupae 12hr    46 white prepupae 24hr    45 pupae 2d postWPP    32 pupae 3d postWPP    43 pupae 4d postWPP    39 adult male 01day    41 adult male 05day    44 adult male 30day    46 adult female 01day    36 adult female 05day    27 adult female 30day    28 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    39 embryo 04-06hr    39 embryo 06-08hr    57 embryo 08-10hr    65 embryo 10-12hr    84 embryo 12-14hr    109 embryo 14-16hr    143 embryo 16-18hr    119 embryo 18-20hr    116 embryo 20-22hr    87 embryo 22-24hr    87 larva L1    50 larva L2    32 larva L3 12hr old    29 larva L3 puffstage 1-2    23 larva L3 puffstage 3-6    39 larva L3 puffstage 7-9    44 white prepupae new    49 white prepupae 12hr    46 white prepupae 24hr    45 pupae 2d postWPP    32 pupae 3d postWPP    43 pupae 4d postWPP    39 adult male 01day    41 adult male 05day    44 adult male 30day    46 adult female 01day    36 adult female 05day    27 adult female 30day    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  27 embryo 02-04hr  (39) embryo 04-06hr  (39) embryo 06-08hr  (57) embryo 08-10hr  (65) embryo 10-12hr  (84) embryo 12-14hr  (109) embryo 14-16hr  (143) embryo 16-18hr  (119) embryo 18-20hr  (116) embryo 20-22hr  (87) embryo 22-24hr  (87) larva L1  (50) larva L2  32 larva L3 12hr old  29 larva L3 puffstage 1-2    23 larva L3 puffstage 3-6  (39) larva L3 puffstage 7-9  (44) white prepupae new  (49) white prepupae 12hr  (46) white prepupae 24hr  (45) pupae 2d postWPP  32 pupae 3d postWPP  (43) pupae 4d postWPP  (39) adult male 01day  (41) adult male 05day  (44) adult male 30day  (46) adult female 01day  (36) adult female 05day  27 adult female 30day  28 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    39 embryo 04-06hr    39 embryo 06-08hr    57 embryo 08-10hr    65 embryo 10-12hr    84 embryo 12-14hr  109 embryo 14-16hr  143 embryo 16-18hr  119 embryo 18-20hr  116 embryo 20-22hr    87 embryo 22-24hr    87 larva L1    50 larva L2    32 larva L3 12hr old    29 larva L3 puffstage 1-2    23 larva L3 puffstage 3-6    39 larva L3 puffstage 7-9    44 white prepupae new    49 white prepupae 12hr    46 white prepupae 24hr    45 pupae 2d postWPP    32 pupae 3d postWPP    43 pupae 4d postWPP    39 adult male 01day    41 adult male 05day    44 adult male 30day    46 adult female 01day    36 adult female 05day    27 adult female 30day    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    39 embryo 04-06hr    39 embryo 06-08hr    57 embryo 08-10hr    65 embryo 10-12hr    84 embryo 12-14hr    109 embryo 14-16hr    143 embryo 16-18hr    119 embryo 18-20hr    116 embryo 20-22hr    87 embryo 22-24hr    87 larva L1    50 larva L2    32 larva L3 12hr old    29 larva L3 puffstage 1-2    23 larva L3 puffstage 3-6    39 larva L3 puffstage 7-9    44 white prepupae new    49 white prepupae 12hr    46 white prepupae 24hr    45 pupae 2d postWPP    32 pupae 3d postWPP    43 pupae 4d postWPP    39 adult male 01day    41 adult male 05day    44 adult male 30day    46 adult female 01day    36 adult female 05day    27 adult female 30day    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    41 embryonic 1182-4H    60 embryonic GM2    55 embryonic Kc167    10 embryonic S1    15 embryonic S3    16 leg disc CME L1    51 wing disc CME-W2    40 wing disc ML-DmD8    38 wing disc ML-DmD9    68 wing disc ML-DmD16-c3    51 wing disc ML-DmD21    18 wing disc ML-DmD32    45 haltere disc ML-DmD17-c3    36 eye-antennal disc ML-DmD11    52 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    52 CNS ML-DmBG1-c1    31 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    36 ovary fGS/OSS    42 ovary OSC    66 ovary OSS    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4  (41) embryonic 1182-4H  (60) embryonic GM2  (55) embryonic Kc167    10 embryonic S1    15 embryonic S3    16 leg disc CME L1  (51) wing disc CME-W2  (40) wing disc ML-DmD8  (38) wing disc ML-DmD9  (68) wing disc ML-DmD16-c3  (51) wing disc ML-DmD21    18 wing disc ML-DmD32  (45) haltere disc ML-DmD17-c3  (36) eye-antennal disc ML-DmD11  (52) antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1  (52) CNS ML-DmBG1-c1  (31) CNS ML-DmBG2-c2    16 tumorous blood cells mbn2  (36) ovary fGS/OSS  (42) ovary OSC  (66) ovary OSS  (32) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    41 embryonic 1182-4H    60 embryonic GM2    55 embryonic Kc167    10 embryonic S1    15 embryonic S3    16 leg disc CME L1    51 wing disc CME-W2    40 wing disc ML-DmD8    38 wing disc ML-DmD9    68 wing disc ML-DmD16-c3    51 wing disc ML-DmD21    18 wing disc ML-DmD32    45 haltere disc ML-DmD17-c3    36 eye-antennal disc ML-DmD11    52 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    52 CNS ML-DmBG1-c1    31 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    36 ovary fGS/OSS    42 ovary OSC    66 ovary OSS    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    41 embryonic 1182-4H    60 embryonic GM2    55 embryonic Kc167    10 embryonic S1    15 embryonic S3    16 leg disc CME L1    51 wing disc CME-W2    40 wing disc ML-DmD8    38 wing disc ML-DmD9    68 wing disc ML-DmD16-c3    51 wing disc ML-DmD21    18 wing disc ML-DmD32    45 haltere disc ML-DmD17-c3    36 eye-antennal disc ML-DmD11    52 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    52 CNS ML-DmBG1-c1    31 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    36 ovary fGS/OSS    42 ovary OSC    66 ovary OSS    32 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    41 embryonic 1182-4H    60 embryonic GM2    55 embryonic Kc167    10 embryonic S1    15 embryonic S3    16 leg disc CME L1    51 wing disc CME-W2    40 wing disc ML-DmD8    38 wing disc ML-DmD9    68 wing disc ML-DmD16-c3    51 wing disc ML-DmD21    18 wing disc ML-DmD32    45 haltere disc ML-DmD17-c3    36 eye-antennal disc ML-DmD11    52 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    52 CNS ML-DmBG1-c1    31 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    36 ovary fGS/OSS    42 ovary OSC    66 ovary OSS    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4  (41) embryonic 1182-4H  (60) embryonic GM2  (55) embryonic Kc167    10 embryonic S1    15 embryonic S3    16 leg disc CME L1  (51) wing disc CME-W2  (40) wing disc ML-DmD8  (38) wing disc ML-DmD9  (68) wing disc ML-DmD16-c3  (51) wing disc ML-DmD21    18 wing disc ML-DmD32  (45) haltere disc ML-DmD17-c3  (36) eye-antennal disc ML-DmD11  (52) antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1  (52) CNS ML-DmBG1-c1  31 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2  (36) ovary fGS/OSS  (42) ovary OSC  (66) ovary OSS  32 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    41 embryonic 1182-4H    60 embryonic GM2    55 embryonic Kc167    10 embryonic S1    15 embryonic S3    16 leg disc CME L1    51 wing disc CME-W2    40 wing disc ML-DmD8    38 wing disc ML-DmD9    68 wing disc ML-DmD16-c3    51 wing disc ML-DmD21    18 wing disc ML-DmD32    45 haltere disc ML-DmD17-c3    36 eye-antennal disc ML-DmD11    52 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    52 CNS ML-DmBG1-c1    31 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    36 ovary fGS/OSS    42 ovary OSC    66 ovary OSS    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    41 embryonic 1182-4H    60 embryonic GM2    55 embryonic Kc167    10 embryonic S1    15 embryonic S3    16 leg disc CME L1    51 wing disc CME-W2    40 wing disc ML-DmD8    38 wing disc ML-DmD9    68 wing disc ML-DmD16-c3    51 wing disc ML-DmD21    18 wing disc ML-DmD32    45 haltere disc ML-DmD17-c3    36 eye-antennal disc ML-DmD11    52 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    52 CNS ML-DmBG1-c1    31 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    36 ovary fGS/OSS    42 ovary OSC    66 ovary OSS    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    22 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    35 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    26 Paraquat 5 mM 48 hrs, 4-day adult    28 Paraquat 10 mM 48 hrs, 4-day adult    40 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (32) cold shock, 4-day adult    22 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult  (27) Cadmium 100 mM 48 hrs, 4-day adult  (38) Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult  26 Ethanol 2.5% 3 hrs, larvae L3  (35) Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (30) Caffeine 25 mg/ml 48 hrs, 4-day adult  26 Paraquat 5 mM 48 hrs, 4-day adult  (28) Paraquat 10 mM 48 hrs, 4-day adult  (40) Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    22 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    35 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    26 Paraquat 5 mM 48 hrs, 4-day adult    28 Paraquat 10 mM 48 hrs, 4-day adult    40 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    22 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    35 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    26 Paraquat 5 mM 48 hrs, 4-day adult    28 Paraquat 10 mM 48 hrs, 4-day adult    40 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    22 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    35 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    26 Paraquat 5 mM 48 hrs, 4-day adult    28 Paraquat 10 mM 48 hrs, 4-day adult    40 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  32 cold shock, 4-day adult    22 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult  27 Cadmium 100 mM 48 hrs, 4-day adult  (38) Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult  26 Ethanol 2.5% 3 hrs, larvae L3  (35) Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  30 Caffeine 25 mg/ml 48 hrs, 4-day adult  26 Paraquat 5 mM 48 hrs, 4-day adult  28 Paraquat 10 mM 48 hrs, 4-day adult  (40) Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    22 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    35 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    26 Paraquat 5 mM 48 hrs, 4-day adult    28 Paraquat 10 mM 48 hrs, 4-day adult    40 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    22 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    35 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    26 Paraquat 5 mM 48 hrs, 4-day adult    28 Paraquat 10 mM 48 hrs, 4-day adult    40 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_29 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0260442
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Df(3L)79a rheaKVK-DDD.Ubi-p63E rheaR2531G.Ubi-p63E lethal, with Scer\GAL4elav.PLu rheaGD12050 lethal, with Scer\GAL4Mef2.PR rheaGD12050 lethal, with Scer\GAL4pnr-MD237 rheaGD12050 lethal (with rhea6-66) rhea13-8 rhea14-69 rhea15-39 lethal (with rhea13-8) rhea6-66 rhea14-69 rhea15-39 lethal (with rhea14-69) rhea6-66 rhea13-8 rhea15-39 lethal (with rhea15-39) rhea6-66 rhea13-8 rhea14-69 lethal | embryonic stage rhea6-66 rhea13-8 rhea14-69 rhea15-39 lethal | embryonic stage | recessive rhea1 lethal | pupal stage, with Scer\GAL4pnr-MD237 rheaGD12050 viable rheaMI00296 Other Phenotypes Allele visible | somatic clone rhea1 Phenotype manifest in Allele actin filament & follicle cell | somatic clone rheaunspecified border follicle cell, with Scer\GAL4slbo.2.6 rheaNIG.6831R egg chamber | conditional, with Scer\GAL4hs.PU rheaVDRC.cUa egg chamber | somatic clone rheaunspecified embryonic/larval fat body branch | somatic clone rhea13-8 embryonic/larval midgut primordium rhea2 embryonic/larval somatic muscle rhea1 embryonic/larval somatic muscle, with Scer\GAL4Mef2.PR rheaGD12050 embryonic/larval tracheal system rhea666 rhea1308 rhea1469 rhea1539 embryonic proventriculus rhea2 eye | somatic clone rhea666 rhea1308 rhea1469 rhea1539 gastric caecum primordium rhea2 germ band | rescuable maternal effect rhea2 muscle attachment site rheaunspecified muscle attachment site, with Df(3L)79a rheaKVK-DDD.Ubi-p63E rheaR2531G.Ubi-p63E muscle attachment site | embryonic stage | germline clone, with Df(3L)79a rheaR367A.Ubi-p63E muscle attachment site | rescuable maternal effect rhea2 muscle cell & actin filament & embryo rheaunspecified muscle cell & focal adhesion & embryo rheaunspecified muscle cell | embryonic stage rheaunspecified oocyte | cell non-autonomous | somatic clone rhea2 presumptive embryonic/larval muscle system | embryonic stage | germline clone, with Df(3L)79a rheaR367A.Ubi-p63E tendon cell & basal lamina & embryo rheaunspecified tendon cell & focal adhesion & embryo rheaunspecified tendon cell & microtubule & embryo rheaunspecified tendon cell | embryonic stage rheaunspecified terminal tracheal cell rhea666 rhea1308 rhea1469 rhea1539 terminal tracheal cell | somatic clone rhea2 rhea15-39 rhea14-69 rhea6-66 rhea13-8 wing | somatic clone rhea1
Classical Alleles ( 20 )
For All Classical Alleles Show
Allele of rhea Class Mutagen Stocks Known lesion rhea1 X ray 1 Yes rheaMI00296-BM.0 site specific recombinase 1 Yes rheaMI00296-DV.0 site specific recombinase 1 Yes rheaMI00296-GFSTF.0 site specific recombinase 1 Yes rheaMI00296-mCh.0 site specific recombinase 1 Yes rheaMI00296 1 -- rhea13-8 0 Yes rhea1308 ethyl methanesulfonate 0 Yes rhea14-69 0 Yes rhea1469 ethyl methanesulfonate 0 Yes rhea15-39 0 Yes rhea1539 ethyl methanesulfonate 0 Yes rhea17 ethyl methanesulfonate 0 -- rhea2 0 Yes rhea3 X ray 0 -- rhea6-66 0 Yes rhea666 ethyl methanesulfonate 0 Yes rheaMI00296-KV.0 site specific recombinase 0 Yes rheaMI00296-TRH.0 site specific recombinase 0 Yes rheaunspecified 0 --
Alleles Carried on Transgenic Constructs ( 30 )
For All Alleles Carried on Transgenic Constructs Show
Allele of rhea Class Mutagen Stocks Known lesion rheaGD12050 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes rheaHM05161 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes rheaHMS00799 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes rheaHMS00856 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes rheaABD-KVK-DDD.Scer\UAS.T:Avic\GFP-m6 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes rheaABD-R2531G.Scer\UAS.T:Avic\GFP-m6 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes rheaABD.Scer\UAS.T:Avic\GFP-m6 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes rheaC.Scer\UAS.T:Avic\GFP-m6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes rheaH.Scer\UAS.T:Avic\GFP-m6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes rheaIBS2.Scer\UAS.T:Avic\GFP-m6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes rheaIBS2.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes rheaK2094D.S2098D.IBS2.Scer\UAS.T:Avic\GFP-m6 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - site directed mutagenesis 0 Yes rheaK2094D.S2098D.IBS2.Ubi-p63E.T:Avic\GFP-m6 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - site directed mutagenesis 0 Yes rheaKVK-DDD.Ubi-p63E in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes rheaL2103A.I2104A.IBS2.Scer\UAS.T:Avic\GFP-m6 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - site directed mutagenesis 0 Yes rheaL2103A.I2104A.IBS2.Ubi-p63E.T:Avic\GFP-m6 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - site directed mutagenesis 0 Yes rheaNIG.6831R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes rheaR2531G.Ubi-p63E in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes rheaR367A.IBS1.L2103A.I2104A.IBS2.Ubi-p63E.T:Avic\GFP-m6 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - site directed mutagenesis 0 Yes rheaR367A.Scer\UAS.IBS1.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - site directed mutagenesis 0 Yes rheaR367A.Ubi-p63E.T:Avic\GFP-EGFP 0 Yes rheaR367A.Ubi-p63E in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes rheaR376A.H.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes rheaScer\UAS.cTa in vitro construct - regulatory fusion 0 Yes rheaScer\UAS.IBS1.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes rheaUbi-p63E.PT in vitro construct - regulatory fusion 0 Yes rheaUbi-p63E.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes rheaUbi-p63E.T:Avic\GFP-m6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes rheaUbi.PB in vitro construct - regulatory fusion 0 Yes rheaVDRC.cUa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)79a (Brown et al., 2002, Ghabrial et al., 2011) Df(3L)W10 (Prout et al., 1997)
Not disrupted in	Df(3L)66C-G28 (Levi et al., 2006) Df(3L)BSC13 (Levi et al., 2006) Df(3L)ZP1 (Levi et al., 2006)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12050} NA P{NIG.6831R} NA P{TRiP.HM05161} NA P{TRiP.HMS00799} NA P{TRiP.HMS00856} NA P{UAS-GFP-rhea.IBS2.KS} NA P{UAS-GFP-rhea.IBS2.LI} NA P{UAS-GFP-rhea.IBS2} NA P{UAS-rhea.ABD.GFP} NA P{UAS-rhea.ABD-KVK/DDD.GFP} NA P{UAS-rhea.ABD-R2531G.GFP} NA P{UAS-rhea.IBS1-GFP.R367A} NA P{UAS-rhea.IBS1-GFP} NA P{UAS-rhea.IBS2.GFP} NA P{UAS-talin.C.mGFP} NA P{UAS-talin.H.mGFP} NA P{UAS-talin.H.R376A.GFP} NA P{UAS-talin.T} NA characterization construct P{UAS-GFP-rhea.IBS1.R367A.IBS2.LI} NA P{UAS-GFP-rhea.IBS1.R367A} NA P{Ubi-p63E-rhea.KVK/DDD} NA P{Ubi-p63E-rhea.R2531G} NA P{Ubi-p63E-talin.R367A} NA P{Ubi-p63E-talin} NA P{Ubi-talin.B} NA P{Ubi-talin.GFP} NA P{Ubi-talin-GFP} NA P{VDRC.rhea.U} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}ergic53EP3212 NA P{EPgy2}ergic53EY09736 NA miscellaneous insertions Mi{MIC}rheaMI00296 NA Mi{PT-BM.0}rheaMI00296-BM.0 NA Mi{PT-DV.0}rheaMI00296-DV.0 NA Mi{PT-GFSTF.0}rheaMI00296-GFSTF.0 NA Mi{PT-KV.0}rheaMI00296-KV.0 NA Mi{PT-mCh.0}rheaMI00296-mCh.0 NA Mi{PT-TRH.0}rheaMI00296-TRH.0 NA PBac{PB}ergic53c00306 NA PBac{PB}ergic53c00314 NA
Gene Ontology: Function, Process & Cellular Component ( 20 unique terms )
Terms Based on Experimental Evidence ( 13 terms )
Molecular Function
CV term Evidence References
integrin binding inferred from physical interaction with mys (Tanentzapf et al., 2006) protein binding inferred from physical interaction with wech (Loer et al., 2008)
Biological Process
CV term Evidence References
apposition of dorsal and ventral imaginal disc-derived wing surfaces inferred from mutant phenotype (Prout et al., 1997) border follicle cell migration inferred from mutant phenotype (Kókai et al., 2012) cell adhesion inferred from mutant phenotype (Kiger et al., 2003) larval somatic muscle development inferred from mutant phenotype (Schnorrer et al., 2010) maintenance of epithelial integrity, open tracheal system inferred from mutant phenotype (Levi et al., 2006) muscle attachment inferred from mutant phenotype (Prout et al., 1997) negative regulation of transcription, DNA-dependent inferred from mutant phenotype (Becam et al., 2005) phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006) regulation of cell shape inferred from mutant phenotype (Kiger et al., 2003) terminal branching, open tracheal system inferred from mutant phenotype (Ghabrial et al., 2011) trachea morphogenesis inferred from mutant phenotype (Ghabrial et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
actin binding inferred from electronic annotation with InterPro:IPR002558 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) insulin receptor binding inferred from electronic annotation with InterPro:IPR002404 (FlyBase Curators et al., 2004-) structural constituent of cytoskeleton inferred from electronic annotation with InterPro:IPR015224 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
cell adhesion traceable author statement (Bokel and Brown, 2002) cytoskeletal anchoring at plasma membrane inferred from electronic annotation with InterPro:IPR015224 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Hynes and Zhao, 2000)
Cellular Component
CV term Evidence References
actin cytoskeleton inferred from electronic annotation with InterPro:IPR006077 (FlyBase Curators et al., 2004-) focal adhesion inferred from electronic annotation with InterPro:IPR015224 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Hynes and Zhao, 2000) ruffle inferred from electronic annotation with InterPro:IPR015224 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
rhea - CG17029 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) rhea - CanA1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) rhea - stv anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) rhea - wech anti tag coimmunoprecipitation, anti tag western blot, pull down, western blot (Loer et al., 2008)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions rhea allele Gene References rhea1 mys (Prout et al., 1997) Tig (Martin-Bermudo and Brown, 2000) rhea2 mys (Prout et al., 1997) unspecified if (Brown et al., 2002) mys (Brown et al., 2002) sli (MacMullin and Jacobs, 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64387 DroID - A comprehensive database of gene and protein interactions. • FBgn0260442 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38978 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9VSL8
Orthologs
OrthoDB Orthologs (55) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6BCF67 Dipteran inclusive ortholog search EOG6M920C Insect inclusive ortholog search EOG6SF81P Arthropod inclusive ortholog search EOG695X6M Metazoa inclusive ortholog search EOG69PPR2
Orthologs in Drosophila Species (EOG6BCF67)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\rhea     Drosophila simulans   Dsim\GD14103     Drosophila sechellia   Dsec\GM25065 Y   Drosophila erecta   Dere\GG14324 Y   Drosophila yakuba   Dyak\GE20752 Y   Drosophila ananassae   Dana\GF24334 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19890 Y   Drosophila persimilis   Dper\GL22532 Y   Drosophila willistoni   Dwil\GK13336 Y   Drosophila virilis   Dvir\GJ13049 Y   Drosophila mojavensis   Dmoj\GI12908 Y   Drosophila grimshawi   Dgri\GH15312 Y
Orthologs in non-Drosophila Dipterans (EOG6M920C)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL006222   Anopheles gambiae Malaria mosquito  Agam\AGAP007474   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ802086   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ011390
Orthologs in non-Dipteran Insects (EOG6SF81P)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB41593   Apis mellifera Western honey bee  Amel\GB49872   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG002134   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19649   Atta cephalotes Leafcutter ant  Acep\ACEP11510   Camponotus floridanus Florida carpenter ant  Cflo\CFLO21432   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19384   Linepithema humile Argentine ant  Lhum\LH17461   Pogonomyrmex barbatus Red harvester ant  Pbar\PB10927   Solenopsis invicta Red fire ant  Sinv\SINV15079   Acyrthosiphon pisum Pea aphid  Apim\ACYPI000925   Acyrthosiphon pisum Pea aphid  Apim\ACYPI003888   Bombyx mori Silkmoth  Bmor\BGIBMGA001370   Bombyx mori Silkmoth  Bmor\BGIBMGA001372   Pediculus humanus Human body louse  Phum\PHUM574140   Tribolium castaneum Red flour beetle  Tcas\TC009358
Orthologs in non-Insect Arthropods (EOG695X6M)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Cyp313b1   Daphnia pulex Water flea  Dpux\ADAM20   Daphnia pulex Water flea  Dpux\ARMS2   Ixodes scapularis Deer tick  Isca\ISCW023338
Orthologs in non-Arthropod Metazoa (EOG69PPR2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\Y71G12B.11   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018303gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000241gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_006921gn   Danio rerio Zebrafish  Drer\ENSDARG00000044271   Danio rerio Zebrafish  Drer\tln2   Danio rerio Zebrafish  Drer\tln1   Xenopus tropicalis Western clawed frog  Xtro\tln2   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000014649   Gallus gallus Domestic chicken  Ggal\TLN2   Gallus gallus Domestic chicken  Ggal\TLN1   Mus musculus House mouse  Mmus\Tln2   Mus musculus House mouse  Mmus\Gm17684   Mus musculus House mouse  Mmus\Tln1   Rattus norvegicus Norway rat  Rnor\Tln2   Rattus norvegicus Norway rat  Rnor\Tln1   Homo sapiens Human  Hsap\TLN2   Homo sapiens Human  Hsap\SH2B2   Homo sapiens Human  Hsap\TLN1
Human Orthologs (3)
Gene OMIM HGNC Hsap\TLN2     Hsap\SH2B2     Hsap\TLN1
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila sechellia Dsec\GM25065 Drosophila erecta Dere\GG14324 Drosophila yakuba Dyak\GE20752 Drosophila ananassae Dana\GF24334 Drosophila pseudoobscura pseudoobscura Dpse\GA19890 Drosophila persimilis Dper\GL22532 Drosophila willistoni Dwil\GK13336 Drosophila virilis Dvir\GJ13049 Drosophila mojavensis Dmoj\GI12908 Drosophila grimshawi Dgri\GH15312
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	28950 y1 v1; P{TRiP.HM05161}attP2 30955 y1 w*; Mi{MIC}rheaMI00296 32999 y1 sc* v1; P{TRiP.HMS00799}attP2 33913 y1 sc* v1; P{TRiP.HMS00856}attP2 39650 y1 w*; Mi{PT-BM.0}rheaMI00296-BM.0 39647 y1 w*; Mi{PT-DV.0}rheaMI00296-DV.0/TM6B, Tb1 39648 y1 w*; Mi{PT-mCh.0}rheaMI00296-mCh.0/TM6B, Tb1 39649 y1 w*; Mi{PT-GFSTF.0}rheaMI00296-GFSTF.0/TM6B, Tb1 2296 y1 w1; P{white-un1}70C rhea1 P{neoFRT}80B/TM6B, P{iab-2(1.7)lacZ}6B, Tb1
VDRC	v40399 w1118; P{GD12050}v40399 v40400 w1118; P{GD12050}v40400/CyO
Genomic Clones ( 1 )
	BACR06F06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 89 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD07967
Other clones	MIP14644
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT08165 AT22770 GH26222 GH26532 LD38019 LD41952 LP04076 LP13375
Other clones	776 11316 15192 17831 19895 30876 35941 39027 42583 45574 46044 46610 50813 52966 54081 56203 57143 76018 83579 98400 102189 105906 121910 125340 165522 214223.54 214319.59 214341.72 214411.66 214437.29 527121 569119 AA698127 AI256966 bs40e01 CK01.7C.C6 CK01.19D.B6 CK01.68B.F4 CK01.114C.A6 CK01.125D.C2 EC15154 EC39146 EK003227 EK044003 EK047704 EK054754 EK100105 EK111315 EK118133 EK121922 EK140344 EK156055 EK157729 EK165324 EK167745 EK168924 EK177153 EK178450 EK220925 EK225324 EK242815 EK245224 EK247518 EK268203 EK270023 EN02901 EN07318 EN14557 EP01244 EP02629 EP03658 EP15715 EP19024 EP19806 GH22078 HL03815 LD10626 LD19815 LD46304
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0260442 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38978
Antibody Information
	monoclonal, polyclonal (Brown et al., 2002) polyclonal (Tanentzapf et al., 2006)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: CG6831 Talin (Brody et al., 2000)
Source for database merge of	Source for merge of: Talin rhea (Brown et al., 2002)
Additional comments	mir-190 is located within an intron of rhea. (Stark et al., 2007, Stark et al., 2007)
Other Comments
	rhea is required for maintenance of tracheal terminal branches and luminal organization. (Levi et al., 2006) S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006) rhea is required to specifically inhibit transcription of shg in the somatic follicle cells. (Becam et al., 2005) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in S2R+ cells: cells become round and detached. Kc167 cells are unaffected. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation. (Rogers et al., 2003) Identification: Genetic screen for autosomal mutations that produce blisters in somatic wing clones. (Prout et al., 1997) Mutations affect myo-epidermal junctions or muscle function in embryos. (Prout et al., 1997) Identification: Genetic screen for autosomal mutations that produce blisters in somatic wing clones. 2 alleles of rhea have been isolated. (Prout et al., 1997)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_139981 NM_001259745 NM_001259746 NM_001259747 NM_001274657 NM_001274658 NM_001274659 NM_001274660 RefSeq (Proteins) • NP_648238 NP_001246674 NP_001246675 NP_001246676 NP_001261586 NP_001261587 NP_001261588 NP_001261589 DDBJ / EMBL / GenBank • AAF50399 AAG22814 AAK93553 AF299248 AFH04345 AFH04346 AFH04347 AGB94281 AGB94282 AGB94283 AGB94284 AI541975 AY052129 CZ466353 CZ466360 Entrez Gene - A searchable database of RefSeq genes. • 38978 UniProtKB/TrEMBL • Q9VSL8 Q960C2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Vinculin/alpha-catenin (IPR006077) I/LWEQ domain (IPR002558) Vinculin-binding site-containing domain (IPR015009) FERM central domain (IPR019748) Talin, central (IPR015224) Insulin receptor substrate-1, PTB (IPR002404) FERM conserved site (IPR019747) Pleckstrin homology-like domain (IPR011993) FERM/acyl-CoA-binding protein, 3-helical bundle (IPR014352) Band 4.1 domain (IPR019749) FERM, N-terminal (IPR018979) FERM domain (IPR000299)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64387 DroID - A comprehensive database of gene and protein interactions. • FBgn0260442 DRSC - Results from RNAi screens. • FBgn0260442 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0260442 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0260442 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38978 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /cytoskel/talin1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38978 modMine - Data generated by the modENCODE project. • FBgn0260442 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9VSL8
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	CG6831 (Brown et al., 2002, Brody et al., 2002, Goldstein and Gunawardena, 2000, Rogers et al., 2003, Montana and Littleton, 2006, Krejcí et al., 2009, Carrera et al., 2008, Perkins et al., 2009, Ni et al., 2010.12.1, Cammarato et al., 2011, Yano et al., 2012) CT21159 (Hynes and Zhao, 2000) rhea (MacMullin and Jacobs, 2006, Lo, 2006, Levi et al., 2006, Levi et al., 2006, Stroschein-Stevenson et al., 2006, Venken et al., 2011, Bharadwaj et al., 2013, Vanderploeg et al., 2012, Stark et al., 2007, Dietzl et al., 2007, Loer et al., 2008, Jani and Schock, 2007, Helsten et al., 2008, Ellis et al., 2011, Fernández-Miñán et al., 2007, Tanentzapf et al., 2007, Dominguez-Gimenez et al., 2007, Krejcí et al., 2009, Carrera et al., 2008, Issigonis et al., 2009, Schnorrer et al., 2010, Carmon et al., 2010, Stark et al., 2007, Fernandez-Minan et al., 2008, Beltran et al., 2007, Tanentzapf and Brown, 2006, Wasbrough et al., 2010, Zervas et al., 2011, Franco-Cea et al., 2010, Perkins et al., 2010, Deng et al., 2010, Yano et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Wu et al., 2012) Rhea (Venken et al., 2011, Dibya et al., 2009, Kim et al., 2005) talin (Devenport and Brown, 2004, Petit et al., 2002, Yagi et al., 2004, Becam et al., 2004, Wheeler and Hynes, 2001, Brown, 2000, Torgler et al., 2003, Lo, 2006, Loer et al., 2008, Helsten et al., 2008, Ellis et al., 2011, Devenport et al., 2007, Tanentzapf et al., 2006, Cheung et al., 2009, Tanentzapf and Brown, 2006, He et al., 2010, Perkins et al., 2010) Talin (Kiger et al., 2003, Torgler et al., 2004, Tanentzapf et al., 2004, Brown, 2000, Brown et al., 2000, Brody et al., 2000, Tanentzapf et al., 2003, Hofmeyer et al., 2006, Fernandez-Minan et al., 2008, Ellis et al., 2011) tendrils (Ghabrial et al., 2011) Tln (Senetar and McCann, 2005)
Name Synonym	rhea (Prout et al., 1997, Krejcí et al., 2009, Beckstead et al., 2005, Carmon et al., 2010, Cammarato et al., 2011) talin (Grabbe et al., 2004, Rogers et al., 2003, Trainor, 2004, Montana and Littleton, 2006, Becam et al., 2005, Jani and Schock, 2007, Tanentzapf and Brown, 2006, Tanentzapf et al., 2007, Dominguez-Gimenez et al., 2007, Issigonis et al., 2009, Pines et al., 2011, Yuan et al., 2010, Zervas et al., 2011, Pereira et al., 2011) Talin (Gandille et al., 2007, Senetar and McCann, 2005, Rogers et al., 2003, Bharadwaj et al., 2013, Subramanian et al., 2007, Loer et al., 2008, Loer et al., 2008, Gandille et al., 2010, Liu and Geisbrecht, 2011, Xie and Auld, 2011, Nguyen et al., 2007, Fernández-Miñán et al., 2007, Llense and Martín-Blanco, 2008, Krejcí et al., 2009, Gilsohn and Volk, 2010, Carmon et al., 2010, Gohl et al., 2010, Kókai et al., 2012, Labeau-Dimenna et al., 2012) tendrils (Levi et al., 2005, Ghabrial et al., 2011)
Secondary FlyBase IDs
	FBgn0020254 FBgn0035910
References ( 120 )
Generate a list of	All references relating to this gene ( 120 )
List References by type	Research paper  ( 72 ) Supplementary material  ( 11 ) Review  ( 7 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 12 ) FlyBase analysis  ( 1 ) Conference report  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 2 ) DNA/RNA sequence record  ( 1 )
Recent research papers ( 19 )
	Bharadwaj et al., 2013, Development 140(3): 627--638 Cbl-associated protein regulates assembly and function of two tension-sensing structures in Drosophila. [FBrf0220383] Lewellyn et al., 2013, J. Cell Biol. 200(6): 721--729 Misshapen decreases integrin levels to promote epithelial motility and planar polarity in Drosophila. [FBrf0221046] Staller et al., 2013, Genetics 193(1): 51--61 Depleting Gene Activities in Early Drosophila Embryos with the "Maternal-Gal4-shRNA" System. [FBrf0220341] Garelli et al., 2012, Science 336(6081): 579--582 Imaginal discs secrete insulin-like peptide 8 to mediate plasticity of growth and maturation. [FBrf0218214] Kókai et al., 2012, BMC Dev. Biol. 12: 20 CalpB modulates border cell migration in Drosophila egg chambers. [FBrf0219464] Labeau-Dimenna et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(44): 17983--17988 Thin, a Trim32 ortholog, is essential for myofibril stability and is required for the integrity of the costamere in Drosophila. [FBrf0219862] Pines et al., 2012, Nat. Cell Biol. 14(9): 935--943 Mechanical force regulates integrin turnover in Drosophila in vivo. [FBrf0219413] Vanderploeg et al., 2012, BMC Dev. Biol. 12: 8 Integrins are required for cardioblast polarisation in Drosophila. [FBrf0217831] Wu et al., 2012, Mol. Biol. Evol. 29(2): 689--705 Evolution at the subgene level: domain rearrangements in the Drosophila phylogeny. [FBrf0217460] Yano et al., 2012, J. Neurogenet. 26(1): 53--63 Identification of proteasome components required for apical localization of chaoptin using functional genomics. [FBrf0217843] Ellis et al., 2011, J. Cell Sci. 124(11): 1844--1856 In vivo functional analysis reveals specific roles for the integrin-binding sites of talin. [FBrf0213701] Gabilondo et al., 2011, Mech. Dev. 128(3-4): 208--221 A targeted genetic screen identifies crucial players in the specification of the Drosophila abdominal Capaergic neurons. [FBrf0213290] Ghabrial et al., 2011, PLoS Genet. 7(7): e1002087 A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system. [FBrf0214368] Liu and Geisbrecht, 2011, Dev. Biol. 359(2): 176--189 Moleskin is essential for the formation of the myotendinous junction in Drosophila. [FBrf0216515] Pereira et al., 2011, PLoS ONE 6(12): e26182 Integrin-Dependent Activation of the JNK Signaling Pathway by Mechanical Stress. [FBrf0216993] Pines et al., 2011, Dev. Dyn. 240(1): 36--51 Distinct regulatory mechanisms control integrin adhesive processes during tissue morphogenesis. [FBrf0212613] Venken et al., 2011, Nat. Methods 8(9): 737--743 MiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genes. [FBrf0216331] Xie and Auld, 2011, Development 138(17): 3813--3822 Integrins are necessary for the development and maintenance of the glial layers in the Drosophila peripheral nerve. [FBrf0214589] Zervas et al., 2011, J. Cell Sci. 124(8): 1316--1327 A central multifunctional role of integrin-linked kinase at muscle attachment sites. [FBrf0213331] Show all research papers ...
Recent reviews ( 1 )
	Broadie et al., 2011, Dev. Neurobiol. 71(11): 1102--1130 Extracellular matrix and its receptors in drosophila neural development. [FBrf0216377] Show all reviews ...