talin, tendrils
(preferred name: Rhea) essential for integrin function - crosslinks extracellular matrix-linked integrins to the cytoskeleton - represses E-cadherin Shotgun transcription in follicle cells independently of integrins
Please see the GBrowse view of Dmel\rhea or the JBrowse view of Dmel\rhea for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.46
Alternative translation stop created by use of multiphasic reading frames within coding region.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\rhea using the Feature Mapper tool.
The rhea protein was detected in the cytoplasm of early cellularized embryos. Subsequently, rhea protein concentrated at the membrane of migrating midgut primordial cells and then at muscle attachment sites, specifically at hemi-adherens junctions. In wing imaginal discs the rhea protein localized to focal adhesion like structures at the basal surface.
GBrowse - Visual display of RNA-Seq signals
View Dmel\rhea in GBrowse 23-26
Located on 3L.
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
monoclonal, polyclonal
Source for identity of: CG6831 Talin
Source for merge of: Talin rhea
rhea is required for maintenance of tracheal terminal branches and luminal organization.
S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in S2R+ cells: cells become round and detached. Kc167 cells are unaffected.
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
Identification: Genetic screen for autosomal mutations that produce blisters in somatic wing clones.
Mutations affect myo-epidermal junctions or muscle function in embryos.
Identification: Genetic screen for autosomal mutations that produce blisters in somatic wing clones. 2 alleles of rhea have been isolated.
