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Gene: Dmel\rhea

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General Information
Symbol
Dmel\rhea
Species
D. melanogaster
Name
rhea
Annotation Symbol
CG6831
Feature Type
protein_coding_gene
FlyBase ID
FBgn0260442
Gene Model Status
Current
Stock Availability
17 publicly available
Gene Snapshot
Rhea is fly talin, a large adaptor protein that is essential for all adhesive functions of integrins. It also has at least one role independent of integrins: repressing E-cadherin shg transcription in follicle cells. [Date last reviewed: 2017-07-20]
Other Summaries
Also Known As
talin
Key Links
Genomic Location
Cytogenetic map
66D6-66D7
Sequence location
3L:8,545,001..8,574,409 [+]
Recombination map
3-26
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI Genome Data Viewer
UCSC Genome Browser
Ensembl Genome Browser
PopFly Genome Browser
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
-
Protein Domains/Motifs
InterPro
FERM domain; IRS-type PTB domain; I/LWEQ domain; PH-like domain superfamily; FERM/acyl-CoA-binding protein superfamily; Vinculin-binding site-containing domain; Talin, central; FERM, N-terminal; FERM conserved site; FERM central domain; Band 4.1 domain; Ubiquitin-like domain superfamily; Talin, N-terminal F0 domain; FERM superfamily, second domain; I/LWEQ domain superfamily; Talin, central domain superfamily; Alpha-catenin/vinculin-like superfamily; Talin-1/2, rod-segment
Molecular Function (see GO section for details)
Experimental Evidence
integrin binding; protein binding
Predictions / Assertions
actin binding; actin filament binding; structural constituent of cytoskeleton
Summaries
Gene Model and Products
Number of Transcripts
8
Number of Unique Polypeptides
5

Please see the GBrowse view of Dmel\rhea or the JBrowse view of Dmel\rhea for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.46
Alternative translation stop created by use of multiphasic reading frames within coding region.
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
rhea-RB
FBtr0305210
NM_001259745
9584
2836
rhea-RC
FBtr0305211
NM_001259746
7261
2169
rhea-RD
FBtr0305212
NM_001259747
7373
2169
rhea-RE
FBtr0333105
NM_001274657
9937
2836
rhea-RF
FBtr0333106
NM_139981
9409
2836
rhea-RG
FBtr0333107
NM_001274658
9521
2815
rhea-RH
FBtr0333108
NM_001274659
9265
2689
rhea-RI
FBtr0333109
NM_001274660
9722
513
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
rhea-PB
FBpp0293740
307.0
2836
6.14
NP_001246674
AFH04345
rhea-PC
FBpp0293741
235.3
2169
5.87
NP_001246675
AFH04346
rhea-PD
FBpp0293742
235.3
2169
5.87
NP_001246676
AFH04347
rhea-PE
FBpp0305317
307.0
2836
6.14
NP_001261586
AGB94281
rhea-PF
FBpp0305318
307.0
2836
6.14
NP_648238
AAF50399
rhea-PG
FBpp0305319
304.7
2815
6.20
NP_001261587
AGB94282
rhea-PH
FBpp0305320
291.5
2689
5.95
NP_001261588
AGB94283
rhea-PI
FBpp0305321
58.8
513
7.04
NP_001261589
AGB94284
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

2836 aa isoforms: rhea-PB, rhea-PE, rhea-PF
2169 aa isoforms: rhea-PC, rhea-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\rhea using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (22 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
integrin binding
inferred from physical interaction with FLYBASE:mys; FB:FBgn0004657
(Tanentzapf et al., 2006)
protein binding
inferred from physical interaction with FLYBASE:wech; FB:FBgn0259745
(Loer et al., 2008)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
actin binding
inferred from sequence or structural similarity
(Goldstein and Gunawardena, 2000)
actin filament binding
inferred from electronic annotation with InterPro:IPR006077
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
structural constituent of cytoskeleton
inferred from electronic annotation with InterPro:IPR015224
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (14 terms)
Terms Based on Experimental Evidence (13 terms)
CV Term
Evidence
References
apposition of dorsal and ventral imaginal disc-derived wing surfaces
inferred from mutant phenotype
(Prout et al., 1997)
border follicle cell migration
inferred from mutant phenotype
(Kókai et al., 2012)
cardiac muscle cell-cardiac muscle cell adhesion
inferred from mutant phenotype
(Bogatan et al., 2015)
cell adhesion
inferred from mutant phenotype
(Klapholz et al., 2015)
cell adhesion mediated by integrin
inferred from mutant phenotype
(Perkins et al., 2010)
germ-band shortening
inferred from mutant phenotype
(Klapholz et al., 2015)
larval somatic muscle development
inferred from mutant phenotype
(Schnorrer et al., 2010)
lumen formation, open tracheal system
inferred from high throughput mutant phenotype
(Ghabrial et al., 2011)
maintenance of epithelial integrity, open tracheal system
inferred from mutant phenotype
(Levi et al., 2006)
muscle attachment
inferred from mutant phenotype
(Klapholz et al., 2015, Prout et al., 1997)
negative regulation of transcription, DNA-templated
inferred from mutant phenotype
(Becam et al., 2005)
sarcomere organization
inferred from mutant phenotype
(Perkins et al., 2010)
terminal branching, open tracheal system
inferred from high throughput mutant phenotype
(Ghabrial et al., 2011)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
cell adhesion
traceable author statement
(Bokel and Brown, 2002)
cytoskeletal anchoring at plasma membrane
inferred from electronic annotation with InterPro:IPR015224
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
inferred from sequence or structural similarity
(Hynes and Zhao, 2000)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
focal adhesion
inferred from direct assay
(Delon and Brown, 2009)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
cytoskeleton
inferred from electronic annotation with InterPro:IPR000299
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
focal adhesion
inferred from sequence or structural similarity
(Hynes and Zhao, 2000)
ruffle
inferred from electronic annotation with InterPro:IPR015224
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Expression Data
Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 6
(Brown et al., 2002)
embryonic stage 12
anterior midgut primordium & posterior midgut primordium
(Brown et al., 2002)
embryonic stage 16
muscle attachment site
(Brown et al., 2002)
third instar larval stage
wing disc | restricted
(Brown et al., 2002)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
S2 cell-line
(Wheeler and Hynes, 2001)
Additional Descriptive Data
The rhea protein was detected in the cytoplasm of early cellularized embryos. Subsequently, rhea protein concentrated at the membrane of migrating midgut primordial cells and then at muscle attachment sites, specifically at hemi-adherens junctions. In wing imaginal discs the rhea protein localized to focal adhesion like structures at the basal surface.
(Brown et al., 2002)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
focal adhesion
inferred from direct assay
(Delon and Brown, 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\rhea in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 56 )
For All Classical and Insertion Alleles Show
 
Allele of rhea
Class
Mutagen
Associated Insertion
Stocks
Known lesion
rhea1
1
Yes
rhea2
    0
    Yes
    rhea6-66
    1
    Yes
    rhea15-39
    1
    Yes
    rheaMI00296
      1
      Yes
      rhea13-8
      0
      Yes
      rhea14-69
      0
      Yes
      rhea17
      hypomorphic allele - genetic evidence
      0
      Yes
      rheaB7
      0
      Yes
      rheaMI00296-GFSTF.0
      1
      Yes
      rheaMI00296-mCh.0
      1
      Yes
      rheaC69
      amorphic allele - molecular evidence
      0
      Yes
      rheaA109
      0
      Yes
      rheaB28
      0
      Yes
      rheaB33
      0
      Yes
      rheaB128
      0
      Yes
      rheaC18
      0
      Yes
      rheaC38
      0
      Yes
      rheaC110
      0
      Yes
      rheaunspecified
        0
        --
        rheaMI00296-BM.0
        1
        Yes
        rheaMI00296-DV.0
        1
        Yes
        rheaMI00738
          1
          Yes
          rheaC49
          amorphic allele - molecular evidence
          0
          Yes
          rheaC92
          amorphic allele - molecular evidence
          0
          Yes
          rhea3
          0
          --
          rheaA16
          0
          Yes
          rheaA52
          0
          Yes
          rheaA75
          0
          Yes
          rheaA78
          0
          Yes
          rheaA79
          0
          Yes
          rheaA80
          0
          Yes
          rheaB20
          0
          Yes
          rheaB63
          0
          Yes
          rheaB150
          0
          Yes
          rheaC19
          0
          Yes
          rheaC33
          0
          Yes
          rheaC59
          0
          Yes
          rheaC63
          0
          Yes
          rheaC86
          0
          Yes
          rheaC89
          0
          Yes
          rheaC90
          0
          Yes
          rheaC102
          0
          Yes
          rheaC103
          0
          Yes
          rheaC119
          0
          Yes
          rheaC130
          0
          Yes
          rheaC141
          0
          Yes
          rheaC160
          0
          Yes
          rheaC166
          0
          Yes
          rheaC190
          0
          Yes
          rheaC193
          0
          Yes
          rheaC197
          0
          Yes
          rheaC206
          0
          Yes
          rheaC208
          0
          Yes
          rheaMI00296-KV.0
          0
          Yes
          rheaMI00296-TRH.0
          0
          Yes
          Other relevant insertions
          insertion of mobile activating element
          Name
          Expression Data
          P{EP}ergic53EP3212
          NA
          P{EPgy2}ergic53EY09736
          NA
          miscellaneous insertions
          Name
          Expression Data
          PBac{PB}ergic53c00306
          NA
          PBac{PB}ergic53c00314
          NA
          Transgenic Constructs ( 38 )
          For All Alleles Carried on Transgenic Constructs Show
          Transgenic constructs containing/affecting coding region of rhea
          Allele of rhea
          Mutagen
          Associated Transgenic Construct
          Stocks
          rheaGD12050
          2
          rheaHM05161
          1
          rheaH.UAS.mGFP6
          0
          rheaR376A.H.UAS.GFP
          0
          rheaUbi-p63E.EGFP
          0
          rheaHMS00799
          1
          rheaHMS00856
          1
          rheaGFP
          0
          rheaIBS2.UAS.mGFP6
          0
          rheaNIG.6831R
          0
          rheaR367A.LI.AA.Ubi-p63E.EGFP
          0
          rheaR367A.Ubi-p63E.EGFP
          0
          rheaR367A.Ubi-p63E
          0
          rheaUAS.cTa
          0
          rheaUbi.PB
          0
          rheaUbi-p63E.PT
          0
          rheaΔhead.GFP
          0
          rheafTRG00587.sfGFP-TVPTBF
          1
          rheafTRG00731.sfGFP-TVPTBF
          1
          rheafTRG10236.sfGFP-nlsTTSTF
          1
          rheaABD.UAS.mGFP6
          0
          rheaABD-KVK-DDD.UAS.mGFP6
          0
          rheaABD-R2531G.UAS.mGFP6
          0
          rheaC.UAS.mGFP6
          0
          rheaE1777A.Ubi-p63E.EGFP
          0
          rheaheadless.Ubi.GFP
          0
          rheaIBS2.UAS.GFP
          0
          rheaKS.DD.Ubi-p63E.EGFP
          0
          rheaKVK-DDD.Ubi-p63E
          0
          rheaL334R.Ubi-p63E.EGFP
          0
          rheaLI.AA.Ubi-p63E.EGFP
          0
          rheaR2531G.Ubi-p63E
          0
          rheaVBS1.UASp.GFP
          0
          rheaVBS1.UASp.mCherry
          0
          rheaVBS2.UASp.GFP
          0
          rheaVBS2.UASp.mCherry
          0
          rheaVDRC.cUa
          0
          rheaΔ486-1937.GFP
          0
          Transgenic constructs containing regulatory region of rhea
          vital-reporter construct
          Name
          Expression Data
          P{UAS-GFP-rhea.IBS1.R367A}
          No
          Deletions and Duplications ( 5 )
          Summary of Phenotypes
          For more details about a specific phenotype click on the relevant allele symbol.
          Lethality
          Allele
          lethal, with Df(3L)79a
          lethal, with Scer\GAL4elav.PLu
          lethal, with Scer\GAL4Mef2.PR
          lethal, with Scer\GAL4pnr-MD237
          lethal, with Scer\GAL4tin.CΔ4
          lethal (with rhea6-66)
          lethal (with rhea13-8)
          lethal (with rhea14-69)
          lethal (with rhea15-39)
          lethal | pupal stage, with Scer\GAL4pnr-MD237
          lethal - all die before end of embryonic stage
          lethal - all die before end of embryonic stage | recessive
          partially lethal, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
          partially lethal - majority die, with Scer\GAL4Hand.PU
          viable
          Other Phenotypes
          Allele
          cell adhesion defective, with Df(3L)79a
          cell adhesion defective | recessive
          cell adhesion defective | recessive | somatic clone
          increased cell size | larval stage, with Scer\GAL4hth-GETDB
          majority die during P-stage, with Scer\GAL4Hand.PU
          short lived, with Scer\GAL4Hand.PU
          some die during embryonic stage
          some die during embryonic stage | recessive
          some die during pupal stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
          visible | recessive | somatic clone
          visible | somatic clone
          Phenotype manifest in
          Allele
          actin filament & follicle cell | somatic clone
          adult heart muscle, with Scer\GAL4Hand.PU
          antennal disc | larval stage, with Scer\GAL4hth-GETDB
          border follicle cell, with Scer\GAL4slbo.2.6
          cardial cell, with Scer\GAL4Hand.PU
          cardial cell | larval stage, with Scer\GAL4Hand.PU
          egg chamber | conditional, with Scer\GAL4hs.PU
          egg chamber | somatic clone
          embryo | dorsal closure stage
          embryo | dorsal closure stage, with Df(3L)79a
          embryo | dorsal closure stage (with Df(3L)79a)
          embryo | embryonic stage 12
          embryo | embryonic stage 12 (with Df(3L)79a)
          embryonic/larval fat body branch | somatic clone
          embryonic/larval heart | larval stage, with Scer\GAL4Hand.PU
          embryonic/larval heart | third instar larval stage, with Scer\GAL4Hand.PU
          embryonic/larval heart visceral muscle | third instar larval stage, with Scer\GAL4Hand.PU
          embryonic/larval midgut primordium
          embryonic/larval somatic muscle
          embryonic/larval somatic muscle, with Scer\GAL4Mef2.PR
          embryonic/larval tracheal system
          embryonic proventriculus
          eye | somatic clone
          gastric caecum primordium
          germ band | rescuable maternal effect
          muscle attachment site
          muscle attachment site, with Df(3L)79a
          muscle attachment site | embryonic stage | germline clone, with Df(3L)79a
          muscle attachment site | rescuable maternal effect
          muscle cell & actin filament & embryo
          muscle cell & focal adhesion & embryo
          muscle cell | embryonic stage
          muscle tendon junction
          myofibril, with Scer\GAL4Hand.PU
          oocyte | cell non-autonomous | somatic clone
          presumptive embryonic/larval muscle system | embryonic stage | germline clone, with Df(3L)79a
          sarcomere, with Scer\GAL4Mef2.PR
          tendon cell & basal lamina & embryo
          tendon cell & focal adhesion & embryo
          tendon cell & microtubule & embryo
          tendon cell | embryonic stage
          terminal tracheal cell
          terminal tracheal cell | somatic clone
          tracheal system
          wing | somatic clone
          Orthologs
          Downloads
          Download All DIOPT Orthologs
          Download All OrthoDB Orthologs
          Human Orthologs (via DIOPT v7.1)
          Homo sapiens (Human) (3)
          Species\Gene Symbol
          Score
          Best Score
          Best Reverse Score
          Source
          Compara
          eggNOG
          Hieranoid
          Homologene
          Inparanoid
          Isobase
          OMA
          OrthoDB
          OrthoFinder
          OrthoInspector
          orthoMCL
          Panther
          Phylome
          RoundUp
          TreeFam
          ZFIN
          Alignment
          Complementation?
          Transgene?
          Hsap\TLN2
          14 of 15
          Yes
          Yes
          Hsap\TLN1
          12 of 15
          No
          Yes
          Hsap\TLNRD1
          2 of 15
          No
          Yes
          Model Organism Orthologs (via DIOPT v7.1)
          Mus musculus (laboratory mouse) (3)
          Species\Gene Symbol
          Score
          Best Score
          Best Reverse Score
          Source
          Compara
          eggNOG
          Hieranoid
          Homologene
          Inparanoid
          Isobase
          OMA
          OrthoDB
          OrthoFinder
          OrthoInspector
          orthoMCL
          Panther
          Phylome
          RoundUp
          TreeFam
          ZFIN
          Alignment
          Complementation?
          Transgene?
          Mmus\Tln2
          13 of 15
          Yes
          Yes
          Mmus\Tln1
          11 of 15
          No
          Yes
          Mmus\Tlnrd1
          2 of 15
          No
          Yes
          Rattus norvegicus (Norway rat) (3)
          Rnor\Tln1
          9 of 13
          Yes
          Yes
          Rnor\Tln2
          7 of 13
          No
          Yes
          Rnor\Tlnrd1
          2 of 13
          No
          Yes
          Xenopus tropicalis (Western clawed frog) (2)
          Xtro\tln2
          7 of 12
          Yes
          Yes
          Xtro\tlnrd1
          1 of 12
          No
          Yes
          Danio rerio (Zebrafish) (4)
          Drer\tln1
          11 of 15
          Yes
          Yes
          Drer\tln2a
          10 of 15
          No
          Yes
          Drer\tln2b
          2 of 15
          No
          Yes
          Drer\tlnrd1
          1 of 15
          No
          Yes
          Caenorhabditis elegans (Nematode, roundworm) (1)
          Cele\tln-1
          14 of 15
          Yes
          Yes
          Arabidopsis thaliana (thale-cress) (4)
          Atha\AT2G17043
          1 of 9
          Yes
          Yes
          Atha\AT3G51400
          1 of 9
          Yes
          Yes
          Atha\AT3G51410
          1 of 9
          Yes
          Yes
          Atha\AT4G35200
          1 of 9
          Yes
          Yes
          Saccharomyces cerevisiae (Brewer's yeast) (1)
          Scer\SLA2
          1 of 15
          Yes
          No
          Schizosaccharomyces pombe (Fission yeast) (0)
          No orthologs reported.
          Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919003J )
          Organism
          Common Name
          Gene
          AAA Syntenic Ortholog
          Multiple Dmel Genes in this Orthologous Group
          Drosophila melanogaster
          fruit fly
          Dmel\rhea
          Drosophila suzukii
          Spotted wing Drosophila
          Dsuz\DS10_00003750
          Drosophila simulans
          Dsim\GD14103
          Drosophila sechellia
          Dsec\GM25065
          Drosophila erecta
          Dere\GG14324
          Drosophila yakuba
          Dyak\GE20752
          Drosophila ananassae
          Dana\GF24334
          Drosophila pseudoobscura pseudoobscura
          Dpse\GA19890
          Drosophila persimilis
          Dper\GL22532
          Drosophila willistoni
          Dwil\GK13336
          Drosophila virilis
          Dvir\GJ13049
          Drosophila mojavensis
          Dmoj\GI12908
          Drosophila grimshawi
          Dgri\GH15312
          Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915002G )
          Organism
          Common Name
          Gene
          Multiple Dmel Genes in this Orthologous Group
          Musca domestica
          House fly
          Mdoa\17021150
          Glossina morsitans
          Tsetse fly
          Gmor\GMOY004670
          Lucilia cuprina
          Australian sheep blowfly
          Lcup\FF38_07751
          Mayetiola destructor
          Hessian fly
          Mdes\Mdes014722
          Mayetiola destructor
          Hessian fly
          Mdes\Mdes000258
          Aedes aegypti
          Yellow fever mosquito
          Aaeg\AAEL006222
          Anopheles darlingi
          American malaria mosquito
          Adar\ADAC002250
          Anopheles darlingi
          American malaria mosquito
          Adar\ADAC002257
          Anopheles gambiae
          Malaria mosquito
          Agam\AGAP007474
          Culex quinquefasciatus
          Southern house mosquito
          Cqui\CPIJ011390
          Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W02DE )
          Organism
          Common Name
          Gene
          Multiple Dmel Genes in this Orthologous Group
          Bombyx mori
          Silkmoth
          Bmor\BGIBMGA001370
          Bombyx mori
          Silkmoth
          Bmor\BGIBMGA001371
          Bombyx mori
          Silkmoth
          Bmor\BGIBMGA001372
          Danaus plexippus
          Monarch butterfly
          Dple\DPOGS211677-PA
          Danaus plexippus
          Monarch butterfly
          Dple\DPOGS211678-PA
          Heliconius melpomene
          Postman butterfly
          Hmel\HMEL015881
          Heliconius melpomene
          Postman butterfly
          Hmel\HMEL015879
          Apis florea
          Little honeybee
          Aflo\2408700516
          Apis mellifera
          Western honey bee
          Amel\GB49873
          Apis mellifera
          Western honey bee
          Amel\GB49872
          Bombus impatiens
          Common eastern bumble bee
          Bimp\BIMP24859
          Bombus impatiens
          Common eastern bumble bee
          Bimp\BIMP24860
          Bombus terrestris
          Buff-tailed bumblebee
          Bter\15210003
          Linepithema humile
          Argentine ant
          Lhum\LH17461
          Linepithema humile
          Argentine ant
          Lhum\LH25674
          Megachile rotundata
          Alfalfa leafcutting bee
          Mrot\MROTU:001868
          Nasonia vitripennis
          Parasitic wasp
          Nvit\Nasvi2EG002134
          Dendroctonus ponderosae
          Mountain pine beetle
          Dpod\YQE_03535
          Tribolium castaneum
          Red flour beetle
          Tcas\TC033529
          Pediculus humanus
          Human body louse
          Phum\PHUM574140
          Rhodnius prolixus
          Kissing bug
          Rpro\RPRC007435
          Cimex lectularius
          Bed bug
          Clec\CLEC009792
          Acyrthosiphon pisum
          Pea aphid
          Apim\ACYPI003888
          Acyrthosiphon pisum
          Pea aphid
          Apim\ACYPI000925
          Zootermopsis nevadensis
          Nevada dampwood termite
          Znev\Znev_01319
          Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X02AV )
          Organism
          Common Name
          Gene
          Multiple Dmel Genes in this Orthologous Group
          Strigamia maritima
          European centipede
          Smar\SMAR007090
          Ixodes scapularis
          Black-legged tick
          Isca\ISCW023338
          Stegodyphus mimosarum
          African social velvet spider
          Smim\KFM78418.1
          Tetranychus urticae
          Two-spotted spider mite
          Turt\tetur04g06860
          Tetranychus urticae
          Two-spotted spider mite
          Turt\tetur04g06830
          Tetranychus urticae
          Two-spotted spider mite
          Turt\tetur04g06840
          Tetranychus urticae
          Two-spotted spider mite
          Turt\tetur04g07040
          Tetranychus urticae
          Two-spotted spider mite
          Turt\tetur10g01300
          Daphnia pulex
          Water flea
          Dpux\DAPPUDRAFT_41019
          Daphnia pulex
          Water flea
          Dpux\DAPPUDRAFT_32232
          Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0644 )
          Organism
          Common Name
          Gene
          Multiple Dmel Genes in this Orthologous Group
          Strongylocentrotus purpuratus
          Purple sea urchin
          Spur\Sp-Tln1
          Strongylocentrotus purpuratus
          Purple sea urchin
          Spur\SPU_006921gn
          Strongylocentrotus purpuratus
          Purple sea urchin
          Spur\Sp-Tal1ph
          Ciona intestinalis
          Vase tunicate
          Cint\ENSCING00000009522
          Gallus gallus
          Domestic chicken
          Ggal\TLN2
          Gallus gallus
          Domestic chicken
          Ggal\TLN1
          Human Disease Model Data
          FlyBase Human Disease Model Reports
            Alleles Reported to Model Human Disease (Disease Ontology)
            Download
            Models ( 0 )
            Allele
            Disease
            Evidence
            References
            Interactions ( 0 )
            Allele
            Disease
            Interaction
            References
            Comments ( 0 )
             
            Human Orthologs (via DIOPT v7.1)
            Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
            Homo sapiens (Human)
            Gene name
            Score
            OMIM
            OMIM Phenotype
            Complementation?
            Transgene?
            TLN2; talin 2
            14 of 15
            607349
              TLN1; talin 1
              12 of 15
              186745
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                esyN Network Diagram
                Show neighbor-neighbor interactions:
                Select Layout:
                Legend:
                Protein
                RNA
                Selected Interactor(s)
                Interactions Browser
                View in Interactions Browser
                Please look at the Interaction Group reports for full details of the physical interactions
                protein-protein
                Interacting group
                Assay
                References
                rhea - CalpB
                anti bait coimmunoprecipitation, western blot, enzymatic study
                (Kókai et al., 2012)
                rhea - Rab30
                pull down, peptide massfingerprinting
                (Gillingham et al., 2014)
                rhea - Vinc
                phenotype-based detection assay, fluorescence microscopy, inferred by author
                (Maartens et al., 2016)
                rhea - mys
                phenotype-based detection assay, fluorescence microscopy, inferred by author
                (Tanentzapf et al., 2006)
                rhea - wech
                anti tag coimmunoprecipitation, anti tag western blot, pull down, western blot
                (Loer et al., 2008)
                Summary of Genetic Interactions
                esyN Network Diagram
                esyN Network Key:
                Suppression
                Enhancement
                View in Interactions Browser
                Please look at the allele data for full details of the genetic interactions
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                rhea
                enhanceable
                CalpB
                (Kókai et al., 2012)
                rhea
                suppressible
                if
                (Tanentzapf and Brown, 2006)
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                CalpB
                suppressible
                rhea
                (Kókai et al., 2012)
                CalpB
                enhanceable
                rhea
                (Kókai et al., 2012)
                flw
                enhanceable
                rhea
                (Pronovost et al., 2013)
                Mhc
                suppressible
                rhea
                (Pronovost et al., 2013)
                mys
                enhanceable
                rhea
                (Prout et al., 1997)
                sli
                enhanceable
                rhea
                (MacMullin and Jacobs, 2006)
                Socs36E
                suppressible
                rhea
                (Issigonis et al., 2009)
                Vinc
                suppressible
                rhea
                (Maartens et al., 2016)
                External Data
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DroID - A comprehensive database of gene and protein interactions.
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                Pathways
                Gene Group - Pathway Membership (FlyBase)
                External Data
                Linkouts
                SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                3L
                Recombination map
                3-26
                Cytogenetic map
                66D6-66D7
                Sequence location
                3L:8,545,001..8,574,409 [+]
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                66D6-66D7
                Limits computationally determined from genome sequence between P{lacW}foij8E8 and P{PZ}SrpRβrK561&P{lacW}l(3)j5B6j5B6
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                rhea is not located at 75A-75C, but is elsewhere on 3L.
                (Fristrom, 1997.8.6)
                Experimentally Determined Recombination Data
                Location
                3-26
                (FlyBase, 2016)
                3-20.1
                (Comeron et al., 2012)
                3-
                (Ghabrial et al., 2011, Prout et al., 1997)
                Left of (cM)
                (Ghabrial et al., 2011)
                Right of (cM)
                (Ghabrial et al., 2011)
                Notes
                Located on 3L.
                (Prout et al., 1997)
                Stocks and Reagents
                Stocks (17)
                Genomic Clones (38)
                cDNA Clones (86)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequences
                BDGP DGC clones
                Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                Other clones
                RNAi and Array Information
                Linkouts
                DRSC - Results frm RNAi screens
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                Antibody Information
                Laboratory Generated Antibodies
                 
                polyclonal
                (Tanentzapf et al., 2006)
                monoclonal, polyclonal
                (Brown et al., 2002)
                Commercially Available Antibodies
                 
                Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
                Other Information
                Relationship to Other Genes
                Source for database identify of
                Source for identity of: CG6831 Talin
                (Brody et al., 2000)
                Source for database merge of
                Source for merge of: Talin rhea
                (Brown et al., 2002)
                Additional comments
                mir-190 is located within an intron of rhea.
                (Stark et al., 2007, Stark et al., 2007)
                Other Comments
                rhea is required continuously during heart growth to maintain the one-to-one apposition of myofibril ends between cardiomyocytes. Retracted myofibrils cannot regenerate appositions to adjacent cells if normal rhea expression is subsequently restored.
                (Bogatan et al., 2015)
                Distinct combinations of talin (rhea) domains are required for each of three different integrin functions during development. The talin IBS2 domain is separated from integrins in the muscles but not at wing adhesion sites, and this separation partly requires myosin activity and Vinc.
                (Klapholz et al., 2015)
                rhea is required for maintenance of tracheal terminal branches and luminal organization.
                (Levi et al., 2006)
                S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
                (Stroschein-Stevenson et al., 2006)
                rhea is required to specifically inhibit transcription of shg in the somatic follicle cells.
                (Becam et al., 2005)
                dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
                (Kiger et al., 2003)
                RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in S2R+ cells: cells become round and detached. Kc167 cells are unaffected.
                (Kiger et al., 2003)
                dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
                (Rogers et al., 2003)
                Identification: Genetic screen for autosomal mutations that produce blisters in somatic wing clones.
                (Prout et al., 1997)
                Mutations affect myo-epidermal junctions or muscle function in embryos.
                (Prout et al., 1997)
                Identification: Genetic screen for autosomal mutations that produce blisters in somatic wing clones. 2 alleles of rhea have been isolated.
                (Prout et al., 1997)
                Origin and Etymology
                Discoverer
                Etymology
                Identification
                External Crossreferences and Linkouts ( 77 )
                Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                InterPro - A database of protein families, domains and functional sites
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                Flygut - An atlas of the Drosophila adult midgut
                FlyMine - An integrated database for Drosophila genomics
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                KEGG Genes - Molecular building blocks of life in the genomic space.
                modMine - A data warehouse for the modENCODE project
                SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                Synonyms and Secondary IDs (8)
                Reported As
                Symbol Synonym
                CG6831
                (Balakrishnan et al., 2015, Hosono et al., 2015, Christis and Munro, 2012, Yano et al., 2012, Cammarato et al., 2011, Ni et al., 2010.12.1, Krejcí et al., 2009, Perkins et al., 2009, Carrera et al., 2008, Montana and Littleton, 2006, Rogers et al., 2003, Brody et al., 2002, Brown et al., 2002, Goldstein and Gunawardena, 2000)
                CT21159
                (Hynes and Zhao, 2000)
                Rhea
                (Wang et al., 2014, Venken et al., 2011, Dibya et al., 2009, Kim et al., 2005)
                Talin
                (Qin et al., 2017, Valdivia et al., 2017, Pérez-Moreno et al., 2014, Johnson et al., 2013, Patel and Myat, 2013, Gates, 2012, Ellis et al., 2011, Ribeiro et al., 2011, Gohl et al., 2010, Fernandez-Minan et al., 2008, Hofmeyer et al., 2006, Tanentzapf et al., 2004, Torgler et al., 2004, Kiger et al., 2003, Tanentzapf et al., 2003, Brody et al., 2000, Brown, 2000, Brown et al., 2000)
                Tln
                (Senetar and McCann, 2005)
                rhea
                (Klapholz and Brown, 2017, Rohde et al., 2017, Vanderploeg and Jacobs, 2017, De Lella Ezcurra et al., 2016, Sarov et al., 2016, Álvarez-Fernández et al., 2015, Gene Disruption Project members, 2015-, Klapholz et al., 2015, Maartens and Brown, 2015, Morozova et al., 2015, Ashwal-Fluss et al., 2014, Chen et al., 2014, Ellis et al., 2014, Gómez-Lamarca et al., 2014, Gupta et al., 2014, Perkins and Tanentzapf, 2014, Bharadwaj et al., 2013, Comber et al., 2013, Kwon et al., 2013, Lin et al., 2013, Moreira et al., 2013, Zhang et al., 2013, Gates, 2012, Japanese National Institute of Genetics, 2012.5.21, Vanderploeg et al., 2012, Wu et al., 2012, Yano et al., 2012, Ellis et al., 2011, Friedman et al., 2011, Knox et al., 2011, Venken et al., 2011, Zervas et al., 2011, Carmon et al., 2010, Deng et al., 2010, Franco-Cea et al., 2010, Perkins et al., 2010, Schnorrer et al., 2010, Wasbrough et al., 2010, Issigonis et al., 2009, Krejcí et al., 2009, Carrera et al., 2008, Fernandez-Minan et al., 2008, Helsten et al., 2008, Loer et al., 2008, Beltran et al., 2007, Dietzl et al., 2007, Dominguez-Gimenez et al., 2007, Fernández-Miñán et al., 2007, Jani and Schock, 2007, Stark et al., 2007, Stark et al., 2007, Tanentzapf et al., 2007, Levi et al., 2006, Levi et al., 2006, Lo, 2006, MacMullin and Jacobs, 2006, Stroschein-Stevenson et al., 2006, Tanentzapf and Brown, 2006)
                talin
                (Tavares et al., 2015, Tiwari et al., 2015, Ellis et al., 2014, Koride et al., 2014, Xie et al., 2014, Ellis et al., 2013, Lin et al., 2013, Gates, 2012, Ellis et al., 2011, He et al., 2010, Perkins et al., 2010, Cheung et al., 2009, Helsten et al., 2008, Loer et al., 2008, Devenport et al., 2007, Lo, 2006, Tanentzapf and Brown, 2006, Tanentzapf et al., 2006, Becam et al., 2004, Devenport and Brown, 2004, Yagi et al., 2004, Torgler et al., 2003, Petit et al., 2002, Wheeler and Hynes, 2001, Brown, 2000)
                tendrils
                (Ghabrial et al., 2011)
                Name Synonyms
                Talin
                (Bogatan et al., 2015, Bharadwaj et al., 2013, Pronovost et al., 2013, Weavers and Skaer, 2013, Kókai et al., 2012, Labeau-Dimenna et al., 2012, Liu and Geisbrecht, 2011, Xie and Auld, 2011, Carmon et al., 2010, Gandille et al., 2010, Gilsohn and Volk, 2010, Gohl et al., 2010, Krejcí et al., 2009, Llense and Martín-Blanco, 2008, Loer et al., 2008, Loer et al., 2008, Fernández-Miñán et al., 2007, Gandille et al., 2007, Nguyen et al., 2007, Subramanian et al., 2007, Senetar and McCann, 2005, Rogers et al., 2003)
                rhea
                (Cammarato et al., 2011, Carmon et al., 2010, Krejcí et al., 2009, Beckstead et al., 2005, Prout et al., 1997)
                talin
                (Bulgakova et al., 2017, Maartens et al., 2016, Koride et al., 2014, Pézeron et al., 2014, Ribeiro et al., 2014, Comber et al., 2013, Lin et al., 2013, Patel and Myat, 2013, Bulgakova et al., 2012, Knox et al., 2011, Pereira et al., 2011, Pines et al., 2011, Zervas et al., 2011, Yuan et al., 2010, Delon and Brown, 2009, Issigonis et al., 2009, Dominguez-Gimenez et al., 2007, Jani and Schock, 2007, Tanentzapf et al., 2007, Montana and Littleton, 2006, Tanentzapf and Brown, 2006, Becam et al., 2005, Grabbe et al., 2004, Trainor, 2004, Rogers et al., 2003)
                tendrils
                (Ghabrial et al., 2011, Levi et al., 2005)
                Secondary FlyBase IDs
                • FBgn0035910
                • FBgn0020254
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                References (200)