FlyBase Gene Report: Dmel\qvr

General Information

Symbol

Dmel\qvr

Species

D. melanogaster

Name

quiver

Annotation Symbol

CG33472

Feature Type

protein_coding_gene

FlyBase ID

FBgn0260499

Gene Model Status

Current

Stock Availability

13 publicly available

Gene Summary

quiver (qvr) encodes a Ly-6 protein. Ly-6 proteins are GPI-linked or secreted proteins that modulate the trafficking and/or activity of membrane protein targets, including the potassium channel encoded by Sh and nicotinic acetylcholine receptors. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
UniProtKB
Interactive Fly

Also Known As

sss, sleepless

Key Links

Genomic Location

Cytogenetic map

47F13-47F13

Sequence location

2R:11,442,505..11,451,604 [+]

Recombination map

2-64

RefSeq locus

NT_033778 REGION:11442505..11451604

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

enables acetylcholine receptor inhibitor activity

inferred from genetic interaction with FLYBASE:nAChRα3; FB:FBgn0015519

(Wu et al., 2014)

inferred from genetic interaction with FLYBASE:nAChRβ3; FB:FBgn0031261

(Wu et al., 2014)

enables GPI anchor binding

inferred from direct assay

(Koh et al., 2008)

enables potassium channel activator activity

inferred from direct assay

(Wu et al., 2014)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (5 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in negative regulation of membrane potential

inferred from genetic interaction with FLYBASE:nAChRα4; FB:FBgn0266347

(Shi et al., 2014)

involved_in positive regulation of circadian sleep/wake cycle, sleep

inferred from mutant phenotype

(Pimentel et al., 2016, Koh et al., 2008)

involved_in regulation of circadian sleep/wake cycle, sleep

inferred from mutant phenotype

(Koh et al., 2008)

involved_in regulation of synaptic transmission, cholinergic

inferred from mutant phenotype

(Wu et al., 2010)

involved_in sleep

inferred from genetic interaction with FLYBASE:nAChRα4; FB:FBgn0266347

(Shi et al., 2014)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in regulation of synaptic transmission, cholinergic

inferred from electronic annotation with InterPro:IPR031424

(InterPro Project Members, 2004-)

involved_in sleep

inferred from electronic annotation with InterPro:IPR031424

(InterPro Project Members, 2004-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in external side of plasma membrane

inferred from direct assay

(Koh et al., 2008)

located_in plasma membrane

inferred from direct assay

(Koh et al., 2008)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Belongs to the quiver family. (B5A5T4)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Protein Function (UniProtKB)

Bifunctional regulator of neuronal activity in the mushroom body, and possibly other regions of the brain, that acts as a signaling molecule required for homeostatic regulation of sleep under normal conditions and after sleep deprivation (PubMed:18635795, PubMed:20010822, PubMed:24613312). Reduces neuronal excitability by enhancing Sh/shaker K(+) channel activity; possibly by stabilizing Sh/shaker to increase protein levels, accelerating its activation kinetics, slowing C-type inactivation and enhancing recovery from inactivation (PubMed:10934243, PubMed:18635795, PubMed:20010822, PubMed:20429677, PubMed:21813698, PubMed:24613312). Specifically affects the A-type K(+) current (PubMed:10934243). Antagonizes nicotinic acetylcholine receptors (nAChRs) to reduce synaptic transmission, possibly by preventing their localization to the cell surface (PubMed:24613312, PubMed:26828958). Required for regulation of neuromuscular excitability and plasticity at neuromuscular junctions (PubMed:29117754).

(UniProt, B5A5T4)

Summary (Interactive Fly)

an Ly-6/Neurotoxin family member - a novel potassium channel subunit that regulates levels, localization, and activity of Shaker - regulates sleep

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\qvr for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry B5A5T4)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.49

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

qvr-RB

FBtr0114575

NM_001144174

5055

158

qvr-RC

FBtr0339545

NM_001299389

5046

155

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

qvr-PB

FBpp0113067

18.1

158

7.26

FBpp0308628

17.8

155

7.55

A0A0B4LEU0

NP_001286318

AHN56116

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts (via loop 2 of the three-fingered Ly-6 domain) with Sh/shaker; this interaction may stabilize both components of the complex and may be required for targeting or retention of Sh/shaker to neural cell projections (PubMed:20010822, PubMed:24613312, PubMed:26828958). Interacts (via loop 2 of the three-fingered Ly-6 domain) with nAChRalpha3 and potentially other nicotinic acetylcholine receptors; this interaction is required for antagonism of nicotinic acetylcholine receptors (PubMed:24613312, PubMed:26828958).

(UniProt, B5A5T4)

Post Translational Modification

N-glycosylated probably on Asn-57.

(UniProt, B5A5T4)

Domain

Consists of a single Ly-6 domain, adopting a three finger fold stabilized by 5 disulfide bonds (Probable). The first loop contains a region essential for protein folding or that is required for localization to the cell surface (PubMed:26828958). The second loop mediates protein-protein interactions (PubMed:24613312, PubMed:26828958).

(UniProt, B5A5T4)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\qvr using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

qvr_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.75

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult mushroom body | restricted

(Wu et al., 2010)

adult protocerebrum | restricted

(Wu et al., 2010)

anterior optic tubercle | restricted

(Wu et al., 2010)

adult antennal nerve

(Wu et al., 2010)

lobula plate | restricted

(Wu et al., 2010)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

qvr is expressed in a group of visual projection neurons (VPN fibers) that send processes to the lobula plate.

(Wu et al., 2010)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in external side of plasma membrane

inferred from direct assay

(Koh et al., 2008)

located_in plasma membrane

inferred from direct assay

(Koh et al., 2008)

Expression Deduced from Reporters

Reporter: P{qvr-GAL4.W}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult mushroom body | restricted

(Wu et al., 2010)

adult antennal nerve

(Wu et al., 2010)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\qvr in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\qvr

View exonic expression by tissue for Dmel\qvr

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

2768718/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0260499

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0053472

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0260499

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG33472

Flygut - An atlas of the Drosophila adult midgut

FBgn0260499

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 14 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of qvr

Transgenic constructs containing regulatory region of qvr

Aberrations (Deficiencies and Duplications) ( 9 )

Inferred from experimentation ( 9 )

Gene disrupted in

Df(2R)en-B

(Wang et al., 2000, Humphreys et al., 1996)

Df(2R)en-SFX31

(Wang et al., 2000, Humphreys et al., 1996)

Df(2R)qvrΔ1-1

(Wang et al., 2000)

Df(2R)qvrΔ1-2

(Wang et al., 2000)

Df(2R)qvrΔ1-3

(Wang et al., 2000)

Df(2R)qvrΔ1-4

(Wang et al., 2000)

Df(2R)qvrΔ43-1

(Wang et al., 2000)

Df(2R)vg135

(Humphreys et al., 1996)

Gene not disrupted in

Df(2R)en-A

(Humphreys et al., 1996)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

qvr^EY04063

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

qvr^GD5741

viable, with Scer\GAL4^Mef2.PR

qvr^GD5741

viable, with Scer\GAL4^pnr-MD237

qvr^GD5741

Sterility

Allele

fertile

Other Phenotypes

Allele

abnormal behavior

abnormal behavior (with qvr¹)

qvr^EY04063

abnormal behavior (with qvr^EY04063)

abnormal behavior (with qvr^f01257)

qvr^EY04063

abnormal behavior (with qvr^Δ40)

qvr^EY04063

abnormal behavior | recessive

qvr^EY04063

abnormal flight

abnormal locomotor rhythm

qvr^EY04063

abnormal locomotor rhythm | recessive

qvr^EY04063

abnormal neurophysiology

abnormal sleep

qvr^EY04063

abnormal sleep, with Scer\GAL4^GMR23E10

qvr^KK109915

abnormal sleep (with qvr^EY04063)

qvr^f01257

abnormal sleep (with qvr^f01257)

qvr^EY04063

chemical sensitive

qvr¹

chemical sensitive | recessive

qvr¹

decreased sleep | adult stage

qvr^Δ40

decreased sleep | adult stage, with Scer\GAL4^Act.PU

qvr^HMJ21916

decreased sleep | adult stage (with qvr^EY04063)

qvr^Δ40

decreased sleep | adult stage (with qvr^Δ40)

qvr^EY04063

increased cell number | adult stage, with Scer\GAL4^Act.PU

qvr^HMJ21916

increased cell number | adult stage, with Scer\GAL4^nSyb.PS

qvr^HMJ21916

increased cell number | adult stage (with qvr^EY04063)

qvr^Δ40

increased cell number | adult stage (with qvr^Δ40)

qvr^EY04063

increased rate of feeding behavior | adult stage (with qvr^EY04063)

qvr^Δ40

increased rate of feeding behavior | adult stage (with qvr^Δ40)

qvr^EY04063

increased rate of movement | recessive

qvr¹

short lived

uncoordinated

qvr^EY04063

Phenotype manifest in

Allele

adult gut (with qvr^EY04063)

qvr^Δ40

adult gut (with qvr^Δ40)

qvr^EY04063

calyx of adult mushroom body

qvr^EY04063

intestinal stem cell | increased number, with Scer\GAL4^Act.PU

qvr^HMJ21916

intestinal stem cell | increased number, with Scer\GAL4^nSyb.PS

qvr^HMJ21916

intestinal stem cell | increased number (with qvr^EY04063)

qvr^Δ40

intestinal stem cell | increased number (with qvr^Δ40)

qvr^EY04063

lysosome | adult stage

qvr^EY04063

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (0)

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (0)

Mus musculus (laboratory mouse) (0)

Xenopus tropicalis (Western clawed frog) (0)

Danio rerio (Zebrafish) (0)

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\sssh-1

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (2)

Agam\AgaP_AGAP008642

1 of 12

Yes

Agam\AgaP_AGAP011412

1 of 12

Yes

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:qvr. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (16)

rtv

2 of 13

atilla

1 of 13

bero

1 of 13

bou

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

qvr - Sh

anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, anti tag western blot

(Wu et al., 2016, Wu et al., 2014, Wu et al., 2010)

qvr - nAChRα3

anti tag coimmunoprecipitation, anti tag western blot, western blot

(Wu et al., 2016, Wu et al., 2014)

RNA-protein

Physical Interaction

Assay

References

qvr - Zn72D

anti tag coimmunoprecipitation, quantitative reverse transcription pcr

(Sapiro et al., 2020)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

qvr

enhanceable

eag

(Wang et al., 2000)

qvr

suppressible

Gabat

(Zhou et al., 2023, Chen et al., 2015)

qvr

enhanceable

(Wang et al., 2000)

suppressible

(Wu et al., 2014)

suppressible

(Wu et al., 2014)

enhanceable

(Wang et al., 2000)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

eag

enhanceable

qvr

(Wang et al., 2000)

enhanceable

qvr

(Wang et al., 2000)

nAChRα4

enhanceable

qvr

(Shi et al., 2014)

enhanceable

qvr

(Wang et al., 2000)

External Data

Subunit Structure (UniProtKB)

(UniProt, B5A5T4 )

Linkouts

BioGRID - A database of protein and genetic interactions.

77570

DroID - A comprehensive database of gene and protein interactions.

FBgn0260499

MIST (protein-protein) - An integrated Molecular Interaction Database

2768718

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene

gene_with_edited_transcript

(Rodriguez et al., 2012, Graveley et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-64

Cytogenetic map

47F13-47F13

Sequence location

2R:11,442,505..11,451,604 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

47F13-47F13

Limits computationally determined from genome sequence between P{lacW}Tapδ^k17005&P{lacW}k05103 and P{lacW}l(2)k13403^k13403&P{lacW}Egm^k14708

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Based on complementation mapping, aberrations not specified.

(Humphreys et al., 1995)

48A5-48B2

(Humphreys et al., 1995)

Experimentally Determined Recombination Data

Location

2-64

(FlyBase, 2016)

2-64.5

(Comeron et al., 2012)

2-62

(Humphreys et al., 1996)

Left of (cM)

(Humphreys et al., 1996)

Right of (cM)

(Humphreys et al., 1996)

Notes

Stocks and Reagents

Stocks (13)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

30866

w^*; P{UAS-qvr.W}3

30865

w^*; qvr^Δ40/SM6a

58061

y¹ v¹; P{TRiP.HMJ21916}attP40

34309

y¹ w^*; Mi{MIC}qvr^MI02289

43686

y¹ w^*; Mi{MIC}qvr^MI06161

16588

y¹ w^67c23; P{EPgy2}qvr^EY04063/CyO

86367

y¹ w^*; TI{CRIMIC.TG4.1}qvr^{CR01410-TG4.1}/SM6a

Kyoto

104463

w^*; P{GawB}qvr^NP3342

NIG-Fly

HMJ21916

y¹ v¹; P{TRiP.HMJ21916}attP40/CyO

2RG-0097

y² VhaAC39-1^cho-1 v¹; P{U6-qvr.NIG.sgRNA}attP40/CyO

VDRC

v104533

P{KK109915}VIE-260B

v16792

w¹¹¹⁸; P{GD5741}v16792

More stocks available...

Genomic Clones (23)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (111)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0260499

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0260499

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Wu et al., 2010)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

In addition to its previously described role in regulating neuronal excitability (via its interaction with Sh), qvr has a role in regulating cholinergic synaptic transmission, via its antagonistic interaction with nicotinic acetylcholine receptors.

(Wu et al., 2014)

qvr is required for both normal baseline sleep and or rebound sleep after deprivation.

(Koh et al., 2008)

Annotation CG30032 renamed to CG33472 in release 3.2 of the genome annotation.

(FlyBase Genome Annotators, 2004)

New annotation (CG30032) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

qvr may encode a novel K⁺ channel-related polypeptide. qvr and Sh may share the same pathway in the regulation of synaptic transmission.

(Wang et al., 2000)

qvr mutants show paraquat sensitivity as well as a leg shaking phenotype.

(Wang et al., 2000)

Relationship to Other Genes

Source for database merge of

Source for merge of: qvr CG33472

(Koh et al., 2008)

Source for merge of: CG30032 BcDNA:GH06755

(FlyBase, 1996-)

Source for merge of: CG33472 anon-WO02059370.1

(FlyBase, 1996-)

Additional comments

Source for merge of CG30032 BcDNA:GH06755 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Source for merge of CG33472 anon-WO02059370.1 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

The gene is named "sleepless" based on the mutant phenotype; mutants show a reduced amount of daily sleep compared to controls.

(Koh et al., 2008)

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

BcDNA:GH06755

CG30032

(Giot et al., 2003)

CG33472

(National Institute of Genetics Fly Stocks, 2022-, Ruan et al., 2017, Dean et al., 2011, Ni et al., 2010.12.1, Nilton et al., 2010, Hijazi et al., 2009, Keleman et al., 2009.8.5, Koh et al., 2008, LaFerriere et al., 2008, Comet et al., 2006)

Qvr

(Rosenthal and Yuan, 2021)

anon-WO02059370.1

mdcds_22455

(Chen and Oliver, 2014.8.15)

qvr/sleepless

(Murakami et al., 2021)

sss

(Huang et al., 2025, Axelrod et al., 2023, Bedont et al., 2023, Li et al., 2023, Zhou et al., 2023, Belfer et al., 2021, Huang et al., 2020, Öztürk-Çolak et al., 2020, Vaccaro et al., 2020, Allada et al., 2017, Chen et al., 2015, Liu et al., 2014, Shi et al., 2014, Wu et al., 2014, Joiner et al., 2013, Dean et al., 2011, Wu et al., 2010, Koh et al., 2008)

Name Synonyms

CG33472

SLEEPLESS

(Singh et al., 2010)

Sleepless

(Hill et al., 2020, Ly et al., 2018, Pimentel et al., 2016, Dorn and Dorn, 2015, Potdar and Sheeba, 2013)

quiver

(Hill et al., 2020, Iyengar and Wu, 2014, Graveley et al., 2011, Nilton et al., 2010, Wang and Wu, 2010, Kwon et al., 2009, Koh et al., 2008, Ruan and Wu, 2008, Wang et al., 2002, Humphreys et al., 1995)

sleepless

(Shafer, 2025, Malik et al., 2024, Vaughen et al., 2022, Belfer et al., 2021, Funato, 2020, Hill et al., 2018, Allada et al., 2017, Tomita et al., 2017, Shi et al., 2014, Robertson and Keene, 2013, Pandey and Nichols, 2011, Sehgal and Mignot, 2011, Wu et al., 2010, Koh et al., 2008)

Secondary FlyBase IDs

FBgn0014377
FBgn0053472
FBgn0050032
FBgn0062504
FBgn0066054

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 38 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

2768718

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

B5A5T4

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

B5A5T4

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

A0A0B4LEU0

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

B5A5T4

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

2768718/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0260499

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0260499

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG33472

MARRVEL_MODEL - MARRVEL (model organism gene)

2768718

Linkouts

BioGRID - A database of protein and genetic interactions.

77570

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0260499

DroID - A comprehensive database of gene and protein interactions.

FBgn0260499

DRSC - Results frm RNAi screens

FBgn0260499

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

qvr_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0053472

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0260499

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG33472

Flygut - An atlas of the Drosophila adult midgut

FBgn0260499

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC009226

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

2768718

References (102)

The following external sites may use different assemblies or annotations than FlyBase.

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