FB2025_01 , released February 20, 2025
Gene: Dmel\Diap1
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General Information
Symbol
Dmel\Diap1
Species
D. melanogaster
Name
Death-associated inhibitor of apoptosis 1
Annotation Symbol
CG12284
Feature Type
protein_coding_gene
FlyBase ID
FBgn0260635
Gene Model Status
Current
Stock Availability
277 publicly available
Gene Summary
Death-associated inhibitor of apoptosis 1 (Diap1) encodes an E3 ubiquitin ligase with a caspase inhibitor activity that is involved in the control of apoptosis. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

th, thread, DIAP-1, DIAP, Drosophila inhibitor of apoptosis 1

Key Links
Genomic Location
Cytogenetic map
72D1-72D1
Sequence location
Recombination map
3-44
RefSeq locus
NT_037436 REGION:16038410..16051034
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (34 terms)
Molecular Function (12 terms)
Terms Based on Experimental Evidence (10 terms)
CV Term
Evidence
References
enables caspase binding
inferred from physical interaction with FLYBASE:Dcp-1; FB:FBgn0010501
(Leulier et al., 2006)
inferred from physical interaction with FLYBASE:Drice; FB:FBgn0019972
(Leulier et al., 2006)
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process
inferred from direct assay
(Harvey et al., 2001)
inferred from genetic interaction with FLYBASE:Drice; FB:FBgn0019972
(Leulier et al., 2006)
inferred from genetic interaction with FLYBASE:Dronc; FB:FBgn0026404
(Leulier et al., 2006)
inferred from genetic interaction with FLYBASE:Dark; FB:FBgn0263864
(Leulier et al., 2006)
enables cysteine-type endopeptidase inhibitor activity
inferred from direct assay
(Ribeiro et al., 2007, Yan et al., 2004, Wang et al., 1999)
enables NEDD8 ligase activity
inferred from direct assay
(Broemer et al., 2010)
enables protein binding
inferred from physical interaction with FLYBASE:hid; FB:FBgn0003997
(Ryoo et al., 2002, Wang et al., 1999)
inferred from physical interaction with FLYBASE:rpr; FB:FBgn0011706
(Ryoo et al., 2002)
inferred from physical interaction with UniProtKB:Q9VFJ3
(Khan et al., 2008, Igaki et al., 2007)
inferred from physical interaction with FLYBASE:Prx4; FB:FBgn0040308
(Tenev et al., 2002)
inferred from physical interaction with FLYBASE:Dcp-1; FB:FBgn0010501
(Wang et al., 1999)
inferred from physical interaction with UniProtKB:Q9XYF4
(Quinn et al., 2000)
enables ubiquitin conjugating enzyme binding
inferred from physical interaction with FLYBASE:eff; FB:FBgn0011217
(Ryoo et al., 2002)
enables ubiquitin protein ligase activity
inferred from direct assay
(Seo et al., 2014, Yeh and Bratton, 2013, Herman-Bachinsky et al., 2007, Kuranaga et al., 2002, Ryoo et al., 2002)
enables ubiquitin protein ligase binding
inferred from physical interaction with FLYBASE:Diap2; FB:FBgn0015247
(Herman-Bachinsky et al., 2007)
enables ubiquitin-like protein conjugating enzyme binding
inferred from physical interaction with FLYBASE:UbcE2M; FB:FBgn0035853
(Broemer et al., 2010)
enables ubiquitin-specific protease binding
inferred from physical interaction with FLYBASE:DUBAI; FB:FBgn0033738
(Yang et al., 2014)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process
inferred from biological aspect of ancestor with PANTHER:PTN000953271
(GO Reference Genome Project, 2011-)
enables ubiquitin protein ligase activity
inferred from biological aspect of ancestor with PANTHER:PTN000799425
(GO Reference Genome Project, 2011-)
enables ubiquitin-protein transferase activity
traceable author statement
(Hanson et al., 2012)
enables zinc ion binding
inferred from sequence model
(Ying et al., 2011)
Biological Process (19 terms)
Terms Based on Experimental Evidence (18 terms)
CV Term
Evidence
References
involved_in antennal morphogenesis
inferred from mutant phenotype
(Cullen and McCall, 2004)
involved_in apoptotic process
inferred from physical interaction with FLYBASE:hid; FB:FBgn0003997
(Goyal et al., 2000)
inferred from physical interaction with FLYBASE:rpr; FB:FBgn0011706
(Goyal et al., 2000)
involved_in border follicle cell migration
inferred from mutant phenotype
(Geisbrecht and Montell, 2004)
inferred from genetic interaction with FLYBASE:Rac1; FB:FBgn0010333
(Geisbrecht and Montell, 2004)
involved_in chaeta development
inferred from mutant phenotype
(Kanuka et al., 2005)
involved_in negative regulation of apoptotic process
inferred from genetic interaction with FLYBASE:egr; FB:FBgn0033483
(Li et al., 2019, Ma et al., 2012, Moreno et al., 2002)
inferred from direct assay
(Quinn et al., 2000)
inferred from mutant phenotype
(Khan et al., 2008, Igaki et al., 2007)
inferred from direct assay
(Yan et al., 2004, Hawkins et al., 1998)
inferred from genetic interaction with FLYBASE:hid; FB:FBgn0003997
(Goyal et al., 2000)
inferred from genetic interaction with FLYBASE:rpr; FB:FBgn0011706
(Goyal et al., 2000)
inferred from mutant phenotype
(Igaki et al., 2002)
involved_in negative regulation of compound eye retinal cell programmed cell death
inferred from mutant phenotype
(Leulier et al., 2006)
involved_in negative regulation of JNK cascade
inferred from genetic interaction with FLYBASE:Traf4; FB:FBgn0026319
(Kuranaga et al., 2002)
involved_in positive regulation of border follicle cell migration
inferred from mutant phenotype
(Mathieu et al., 2007)
involved_in positive regulation of canonical Wnt signaling pathway
inferred from mutant phenotype
(Hanson et al., 2012)
involved_in positive regulation of protein ubiquitination
inferred from direct assay
(Ditzel et al., 2008)
involved_in positive regulation of Toll signaling pathway
inferred from mutant phenotype
(Wu et al., 2022)
involved_in protein autoubiquitination
inferred from direct assay
(Herman-Bachinsky et al., 2007, Ryoo et al., 2002)
involved_in protein K48-linked ubiquitination
inferred from mutant phenotype
(Yeh and Bratton, 2013)
involved_in protein neddylation
inferred from direct assay
(Broemer et al., 2010)
involved_in protein polyubiquitination
inferred from direct assay
(Herman-Bachinsky et al., 2007, Kuranaga et al., 2002)
involved_in sensory organ precursor cell division
inferred from genetic interaction with FLYBASE:IKKε; FB:FBgn0086657
(Koto et al., 2009)
involved_in spermatid nucleus differentiation
inferred from mutant phenotype
(Huh et al., 2004)
involved_in spermatogenesis
inferred from mutant phenotype
(Lindsley et al., 2013)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in negative regulation of apoptotic process
inferred from biological aspect of ancestor with PANTHER:PTN000953271
(GO Reference Genome Project, 2011-)
involved_in positive regulation of canonical Wnt signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN002559465
(GO Reference Genome Project, 2011-)
involved_in positive regulation of protein ubiquitination
inferred from biological aspect of ancestor with PANTHER:PTN000799425
(GO Reference Genome Project, 2011-)
involved_in regulation of cell cycle
inferred from biological aspect of ancestor with PANTHER:PTN000005168
(GO Reference Genome Project, 2011-)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Shukla and Tapadia, 2011, Baum et al., 2007)
located_in nucleus
inferred from direct assay
(Shukla and Tapadia, 2011, Baum et al., 2007)
located_in perinuclear region of cytoplasm
inferred from direct assay
(Shukla and Tapadia, 2011)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000005166
(GO Reference Genome Project, 2011-)
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000005166
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the IAP family. (Q24306)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Death-associated inhibitor of apoptosis 1 (Diap1) encodes an E3 ubiquitin ligase with a caspase inhibitor activity that is involved in the control of apoptosis. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
INHIBITOR OF APOPTOSIS UBIQUITIN LIGASES -
E3 (ubiquitin) ligases interact with both ubiquitin-E2 (ubiquitin-conjugating) enzymes and the target protein, transferring the ubiquitin from the E2 to the substrate. Inhibitor of APoptosis (IAP) ubiquitin ligases are defined by the presence of one or more BIR (baculoviral IAP repeat) and a UBA (ubiquitin (Ub)-associated domain) domain that binds polyubiquitin and a RING finger domain. (Adapted from FBrf0216918).
INHIBITOR OF APOPTOSIS -
Inhibitor of APoptosis (IAP) proteins are defined by the presence of one or more BIR (baculoviral IAP repeat) domains. Not all IAPs inhibit apoptosis, but some interact with and inhibit caspases via their BIR domains. This interaction is displaced by RHG protein binding. (Adapted from FBrf0215539).
NEDD8 TRANSFERASES -
NEDD8 transferases catalyse the transfer of the ubiquitin-like protein NEDD8 from one substrate to another. They include NEDD8 conjugating (E2) enzymes and NEDD8 ligase (E3) enzymes, which act sequentially in a process analogous to ubiquitination, and result in covalent attachment of NEDD8 to target proteins. Neddylation results in activation of members of the cullin-RING family of ubiquitin E3 ligases, which appear to be the major NEDD8 targets in the cell. (Adapted from PMID:25531226.)
Pathway (FlyBase)
Positive Regulators of Toll-NF-κB Signaling Pathway -
In Drosophila, the canonical Toll signaling pathway is initiated by the binding of a spatzle ligand to Toll (Tl) or a Toll-like receptor leading to the nuclear localization of the NF-κB (dl or Dif) transcription factor. Positive regulators of Toll-NF-κB Signaling lead to the increased nuclear accumulation of the NF-κB proteins and regulated expression of target genes. (Adapted from FBrf0091014 and FBrf0223077).
Protein Function (UniProtKB)
Anti-apoptotic protein which functions as a caspase regulator, using its E3 ubiquitin-protein ligase activity to smother caspase activity. Binds, ubiquitinates and inactivates initiator caspase Dronc, and effector caspases Drice and Dcp-1. Acts as a Nedd8-E3 ubiquitin-protein ligase for Drice. Suppresses apoptosis by targeting the apoptosome for ubiquitination and inactivation. Plays an important role in cell motility. Overexpression suppresses rpr and hid-dependent cell death in the eye. Interaction of Diap1 with Dronc is required to suppress Dronc-mediated cell death through Diap1-mediated ubiquitination of Dronc. Acts as a positive regulator of Wnt signaling.
(UniProt, Q24306)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
th: thread
Aristae threadlike, without side branches. Mutation affects development of tarsal claws at 29 (Mglinetz and Ivanov, 1975). Deficiency for th homozygous lethal (Ward and Alexander, 1957; Korge, 1972). Mutant males and females less successful in mating than wild-type (Burnet, Connolly, and Dennis, 1971, Anim. Behav. 19: 409-15).
Summary (Interactive Fly)

ubiquitin ligase that functions as an inhibitor of apoptosis - the inhibition of caspase function is counteracted by proapoptotic proteins Hid, Grim and Reaper - niche signaling promotes stem cell survival in the Drosophila testis via the Jak-STAT target DIAP1

Gene Model and Products
Number of Transcripts
6
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Diap1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q24306)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.46

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Diap1-RA
FBtr0075500
NM_079377
2018
438
Diap1-RB
FBtr0075499
NM_168644
1870
438
Diap1-RC
FBtr0075501
NM_168645
1820
438
Diap1-RD
FBtr0333617
NM_001274987
1754
438
Diap1-RE
FBtr0333618
NM_001274988
2304
438
Diap1-RF
FBtr0333619
NM_001274989
2233
438
Additional Transcript Data and Comments
Reported size (kB)

2.0 (longest cDNA)

(Hay et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Diap1-PA
FBpp0075255
48.0
438
5.06
Q24306
NP_524101
AAF49548
Diap1-PB
FBpp0075254
48.0
438
5.06
Q24306
NP_730097
AAG22319
Diap1-PC
FBpp0075256
48.0
438
5.06
Q24306
NP_730098
AAN11757
Diap1-PD
FBpp0305793
48.0
438
5.06
Q24306
NP_001261916
AGB94609
Diap1-PE
FBpp0305794
48.0
438
5.06
Q24306
NP_001261917
AGB94610
Diap1-PF
FBpp0305795
48.0
438
5.06
Q24306
NP_001261918
AGB94611
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

438 aa isoforms: Diap1-PA, Diap1-PB, Diap1-PC, Diap1-PD, Diap1-PE, Diap1-PF
Additional Polypeptide Data and Comments
Reported size (kDa)

438 (aa)

(Hay et al., 1995)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts (via BIR 2 domain) with Dronc (via residues 114-125) (PubMed:10675329, PubMed:10984473, PubMed:14517550). Rpr, hid and grim can outcompete Dronc for binding Diap1 therefore removing Diap1-mediated ubiquitination (PubMed:10675329, PubMed:14517550). Interacts (via BIR 2 domain) with HtrA2; this displaces any bound Dronc. Interacts with Strica (PubMed:11550090). The N-terminally cleaved form interacts with Ubr3 (via UBR-type zinc finger) (PubMed:25146930, PubMed:26383956); the interaction promotes the recruitment and uniquitination of substrate capases such as Dronc (PubMed:25146930).

(UniProt, Q24306)
Post Translational Modification

Ubiquitinated and degraded by HtrA2 in apoptotic cells; proteolytic cleavage at specific sites in the BIR domain linker region generating inactive fragments. Mutation of one site reduces but does not abolish cleavage as another site is selected by the protease.

(UniProt, Q24306)
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Diap1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.09

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism | ubiquitous
(Hay et al., 1995)
embryonic stage 1 -- 3
organism | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
anterior endoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
head mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
posterior ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
trunk mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 5 -- 6
mesectoderm | subset
(Kearney et al., 2004)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
anterior endoderm anlage
(Fisher et al., 2012)
foregut anlage
(Fisher et al., 2012)
hindgut anlage
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
anterior endoderm
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
inclusive hindgut primordium
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 9 -- 12
midline primordium | subset
(Kearney et al., 2004)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
clypeo-labral primordium
(Fisher et al., 2012)
dorsal pharyngeal muscle primordium
(Fisher et al., 2012)
embryonic neuroblast of ventral nerve cord primordium
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
Malpighian tubule primordium
(Fisher et al., 2012)
somatic muscle primordium
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic foregut
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
larval midline neuron
(Kearney et al., 2004)
larval stage
eye-antennal disc
(Hay et al., 1995)
Additional Descriptive Data

Expression pattern inferred from unspecified enhancer trap line.

(Kearney et al., 2004)

th is expressed throughout the eye imaginal disc and in the embryo in most if not all cells.

(Hay et al., 1995)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11
organism | ubiquitous
(Ryoo et al., 2002)
third instar larval stage
salivary gland
(Shukla and Tapadia, 2011)
Malpighian tubule
• nucleus
(Shukla and Tapadia, 2011)
late third instar larval stage
wing disc | ubiquitous

Comment: Expression strongest at D/V boundary

(Ryoo et al., 2002)
dorsal-ventral compartment boundary of the wing disc
(Ryoo et al., 2002)
prepupal stage P4(ii) -- pupal stage P5
salivary gland

Comment: reference states 12-14h APF

(Shukla and Tapadia, 2011)
Malpighian tubule

Comment: reference states 12-14h APF

(Shukla and Tapadia, 2011)
oogenesis stage S1 -- S7 & adult stage | female
nurse cell
(Baum et al., 2007)
follicle cell
(Baum et al., 2007)
oogenesis stage S9 -- S11 & adult stage | female
nurse cell
(Baum et al., 2007)
follicle cell
(Baum et al., 2007)
adult stage | male & spermatogenesis
cyst progenitor cell
(Hasan et al., 2015)
male germline stem cell
(Hasan et al., 2015)
oogenesis stage S9 -- S10
oocyte | ubiquitous
(Geisbrecht and Montell, 2004)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism
(Ryoo et al., 2002)
third instar larval stage
salivary gland
(Shukla and Tapadia, 2011)
Malpighian tubule
(Shukla and Tapadia, 2011)
prepupal stage P4(ii) -- pupal stage P5
Malpighian tubule

Comment: reference states 12-14h APF

(Shukla and Tapadia, 2011)
Additional Descriptive Data

While larval salivary gland, pupal salivary gland, and pupal Malpighian tubules all show full-length Diap1 transcripts, only the larval salivary gland also shows a band of cleaved Diap1 at 36 kDa.

(Shukla and Tapadia, 2011)

Immunostaining of wild-type ovarioles with anti-Diap1 revealed that Diap1 expression was high from the germarium until stage 7. It then decreased during stages 7-8, before increasing again at stages 9-11. Expression decreased again at stage 11, and localization of Diap1 shifted from nuclear to cytoplasmic.

(Baum et al., 2007)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Shukla and Tapadia, 2011, Baum et al., 2007)
located_in nucleus
inferred from direct assay
(Shukla and Tapadia, 2011, Baum et al., 2007)
located_in perinuclear region of cytoplasm
inferred from direct assay
(Shukla and Tapadia, 2011)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Diap1 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 87 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 48 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Diap1
Transgenic constructs containing regulatory region of Diap1
Aberrations (Deficiencies and Duplications) ( 37 )
Inferred from experimentation ( 37 )
Gene disrupted in
Df(3L)brm11
(Cooper and Kennison, 2011, Colussi et al., 2000, Wang et al., 1999, Szeged Stock Center, 1998-, Melendez et al., 1995)
Df(3L)BSC443
(Cooper and Kennison, 2011)
Df(3L)BSC774
(Cooper and Kennison, 2011)
Df(3L)G63
(Muller et al., 1999)
Df(3L)st-f13
(Cooper and Kennison, 2011, Colussi et al., 2000, Spradling et al., 1999, Szeged Stock Center, 1998-, Deak et al., 1997, Melendez et al., 1995, BDGP Project Members, 1994-1999)
Df(3L)st-g24
(Cooper and Kennison, 2011)
Df(3L)th1
(Ashburner et al., 1981, Velissariou and Ashburner, 1981)
Df(3L)th2
(Velissariou and Ashburner, 1981)
Df(3L)th45
(Velissariou and Ashburner, 1981)
Df(3L)th70i
(Korge, 1972)
Df(3L)th70kI
(Korge, 1972)
Df(3L)th70kII
(Korge, 1972)
Df(3L)th70l
(Korge, 1972)
Df(3L)th102
(Cooper and Kennison, 2011, Kennison, 1995.6.21, Melendez et al., 1995, Velissariou and Ashburner, 1981)
Df(3L)th105
(Ward and Alexander, 1957)
Df(3L)th112
(Velissariou and Ashburner, 1981)
Df(3L)th113
(Velissariou and Ashburner, 1981)
Df(3L)th117
(Cooper and Kennison, 2011, Kennison, 1995.6.21, Melendez et al., 1995, Velissariou and Ashburner, 1981)
Tp(3;3)th100.293
(Ward and Alexander, 1957)
Gene not disrupted in
Df(3L)A5
(Melendez et al., 1995)
Df(3L)A27
(Melendez et al., 1995)
Df(3L)BK10
(Melendez et al., 1995)
Df(3L)Brd6
(Melendez et al., 1995)
Df(3L)Brd20
(Melendez et al., 1995)
Df(3L)DTS5-3
(Velissariou and Ashburner, 1981)
Df(3L)DTS5-4
(Velissariou and Ashburner, 1981)
Df(3L)Q26
(Melendez et al., 1995)
Df(3L)st2
(Velissariou and Ashburner, 1981)
Df(3L)st3
(Velissariou and Ashburner, 1981)
Df(3L)st4
(Spradling et al., 1999, BDGP Project Members, 1994-1999, Velissariou and Ashburner, 1981)
Df(3L)st6
(Velissariou and Ashburner, 1981)
Df(3L)st7
(Velissariou and Ashburner, 1981)
Df(3L)st103
(Velissariou and Ashburner, 1981)
Df(3L)st106
(Velissariou and Ashburner, 1981)
In(3L)st5
(Velissariou and Ashburner, 1981)
Gene duplicated in
Ts(YLt;3Lt)I
Ts(YSt;3Lt)ST1
(Brizuela et al., 1994, Lindsley and Zimm, 1992)
Inferred from location ( 5 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4pnr-MD237
lethal (with Df(3L)brm11)
lethal (with Df(3L)st-f13)
lethal | larval stage | recessive
lethal | pupal stage | recessive
lethal | recessive
lethal - all die before end of larval stage | recessive
lethal - all die before end of pupal stage
lethal - all die before end of pupal stage, with Scer\GAL4GMR.PF
lethal - all die before end of pupal stage | heat sensitive
lethal - all die during embryonic stage
lethal - all die during larval stage, with Scer\GAL4Mef2.PR
partially lethal - majority die | recessive
viable
viable (with Diap14)
viable (with Diap15)
viable (with Diap16B)
viable (with Diap17)
viable (with Diap121-2s)
Sterility
Allele
female sterile (with Diap16B)
female sterile (with Diap18)
fertile
male sterile
Other Phenotypes
Allele
abnormal cell death, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4nanos.PG
abnormal cell death | adult stage | nutrition conditional
abnormal cell death | recessive
abnormal cell shape, with Scer\GAL4Act5C.PI
abnormal eye color, with Scer\GAL4GMR.PF
abnormal eye color, with Scer\GAL4GMR.PFa
abnormal eye color, with Scer\GAL4GMR.PU
abnormal gravitaxis
abnormal neuroanatomy
abnormal neuroanatomy, with Scer\GAL4C57
abnormal neuroanatomy, with Scer\GAL4ppk.1.9
abnormal neuroanatomy | pupal stage, with Scer\GAL4ppk.PG
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4CCAP.PP
abnormal oxidative stress response, with Scer\GAL4ple.PF
abnormal size | adult stage, with Scer\GAL4GMR.PFa
abnormal size | adult stage, with Scer\GAL4GMR.PU
abnormal size | adult stage | dominant
abnormal size | third instar larval stage
chemical resistant, with Scer\GAL4ple.PF
decreased cell death | adult stage
increased cell death
increased cell death, with Scer\GAL434B
increased cell death, with Scer\GAL4GMR.PF
increased cell death, with Scer\GAL4GMR.PU
increased cell death, with Scer\GAL4VP16.nanos.UTR
increased cell death | adult stage, with Scer\GAL4GMR.PU
increased cell death | conditional
increased cell death | heat sensitive
increased cell death | larval stage, with Scer\GAL4en.PU
increased cell death | larval stage, with Scer\GAL4nub.PU
increased cell death | larval stage | somatic clone
increased cell death | recessive
increased cell death | somatic clone
increased cell death | third instar larval stage, with Scer\GAL4ap-md544
increased cell death | third instar larval stage, with Scer\GAL4CCAP.PP
increased cell death | third instar larval stage, with Scer\GAL4GMR.PF
increased cell number | adult stage | dominant
some die during embryonic stage
some die during larval stage | recessive
some die during pupal stage
some die during pupal stage, with Scer\GAL4GMR.PF
some die during pupal stage | heat sensitive
visible
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4GMR.PU
visible, with Scer\GAL4sca-P309
visible | adult stage, with Scer\GAL4GMR.PFa
visible | recessive
Phenotype manifest in
Allele
antennal disc | third instar larval stage
arista
arista (with Df(3L)th102)
arista lateral
arista lateral (with Df(3L)th102)
arista lateral | ectopic, with Scer\GAL4T80
autophagosome | somatic clone | third instar larval stage, with Scer\GAL4Act.PU
border follicle cell (with Diap14)
border follicle cell (with Diap15)
border follicle cell (with Diap17)
border follicle cell (with Diap121-2s)
border follicle cell | somatic clone
dendrite
dendrite, with Scer\GAL4ppk.1.9
dendrite | pupal stage, with Scer\GAL4ppk.PG
egg chamber, with Scer\GAL4VP16.nanos.UTR
egg chamber, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4nanos.PG
egg chamber (with Diap15)
egg chamber (with Diap16B)
egg chamber (with Diap18)
egg chamber (with Diap121-2s)
egg chamber | nutrition conditional
embryo
embryonic/larval midgut | heat sensitive
embryonic/larval proventriculus | heat sensitive
embryonic/larval salivary gland, with Scer\GAL4SG
embryonic/larval salivary gland | heat sensitive
embryonic epidermis
embryonic mandibular segment, with Scer\GAL4wg.PM
embryonic maxillary segment, with Scer\GAL4wg.PM
embryonic procephalic segment, with Scer\GAL4wg.PM
eye
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4GMR.PFa
eye, with Scer\GAL4GMR.PU
eye | conditional
eye | P-stage
eye-antennal disc
eye disc | third instar larval stage, with Scer\GAL4GMR.PF
female germline stem cell | germline clone
follicle cell | increased number (with Diap15)
follicle cell | increased number (with Diap121-2s)
follicle cell | nutrition conditional
follicle cell | somatic clone
gastric caecum | heat sensitive
gastric caecum | third instar larval stage, with Scer\GAL4Act.PU
head | pupal stage, with Scer\GAL4CCAP.PP
interommatidial bristle, with Scer\GAL4GMR.PF
larval dorsal multidendritic neuron ddaC, with Scer\GAL4ppk.1.9
larval multidendritic class IV neuron | pupal stage, with Scer\GAL4ppk.PG
leg | pupal stage, with Scer\GAL4CCAP.PP
macrochaeta, with Scer\GAL4sca-109-68
macrochaeta | increased number, with Scer\GAL4sca-P309
male germline cell, with Scer\GAL4VP16.nanos.UTR
minor mitochondrial derivative
neuron
nurse cell | increased number (with Diap15)
nurse cell | increased number (with Diap16B)
nurse cell | increased number (with Diap121-2s)
ommatidial precursor cluster, with Scer\GAL4GMR.PF
ovariole (with Diap16B)
ovariole (with Diap18)
ovary (with Diap16B)
ovary (with Diap18)
peptidergic neuron | adult stage | ectopic
peptidergic neuron | third instar larval stage, with Scer\GAL4CCAP.PP
pigment cell
pigment cell, with Scer\GAL4GMR.PF
pupal cuticle | posterior, with Scer\GAL4CCAP.PP
sensory mother cell | increased number, with Scer\GAL4sca-P309
spermatid
spermatogonial cyst, with Scer\GAL4VP16.nanos.UTR
synapse, with Scer\GAL4C57
testis
waste bag
wing
wing disc | larval stage, with Scer\GAL4en.PU
wing disc | larval stage, with Scer\GAL4nub.PU
wing disc | pupal stage, with Scer\GAL4CCAP.PP
wing disc | third instar larval stage
wing disc | third instar larval stage, with Scer\GAL4ap-md544
wing disc posterior compartment | somatic clone
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (27)
Hsap\BIRC2
9 of 14
Yes
No
Hsap\BIRC3
9 of 14
Yes
No
Hsap\XIAP
7 of 14
No
No
1  
Hsap\BIRC7
6 of 14
No
No
1  
Hsap\BIRC8
4 of 14
No
Yes
Hsap\BIRC5
2 of 14
No
No
Hsap\BIRC6
2 of 14
No
No
Hsap\NAIP
2 of 14
No
No
Hsap\AMFR
1 of 14
No
No
Hsap\LRSAM1
1 of 14
No
Yes
1  
Hsap\MGRN1
1 of 14
No
No
1  
Hsap\MIB1
1 of 14
No
No
6  
Hsap\MYLIP
1 of 14
No
No
Hsap\NEURL1B
1 of 14
No
No
Hsap\NEURL1
1 of 14
No
No
Hsap\NEURL2
1 of 14
No
No
Hsap\NEURL3
1 of 14
No
No
Hsap\NEURL4
1 of 14
No
No
Hsap\RFFL
1 of 14
No
No
Hsap\RLIM
1 of 14
No
No
1  
Hsap\RNF8
1 of 14
No
Yes
Hsap\RNF13
1 of 14
No
No
1  
Hsap\RNF141
1 of 14
No
Yes
Hsap\RNF157
1 of 14
No
No
Hsap\RNF167
1 of 14
No
No
Hsap\RNF170
1 of 14
No
Yes
Hsap\TRIM2
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (25)
Rnor\Birc2
9 of 14
Yes
No
Rnor\Birc3
9 of 14
Yes
No
Rnor\Xiap
8 of 14
No
No
Rnor\Birc7
6 of 14
No
No
Rnor\Birc5
2 of 14
No
No
Rnor\Birc6
2 of 14
No
No
Rnor\Cblc
1 of 14
No
No
Rnor\Lonrf3
1 of 14
No
No
Rnor\Mex3d
1 of 14
No
No
Rnor\Mgrn1
1 of 14
No
No
Rnor\Mib1
1 of 14
No
No
Rnor\Mylip
1 of 14
No
No
Rnor\Naip6
1 of 14
No
Yes
Rnor\Neurl1b
1 of 14
No
No
Rnor\Neurl1
1 of 14
No
No
Rnor\Neurl2
1 of 14
No
No
Rnor\Neurl3
1 of 14
No
No
Rnor\Neurl4
1 of 14
No
No
Rnor\Rffl
1 of 14
No
No
Rnor\Rlim
1 of 14
No
No
Rnor\Rnf13
1 of 14
No
No
Rnor\Rnf26
1 of 14
No
No
Rnor\Rnf123
1 of 14
No
No
Rnor\Rnf157
1 of 14
No
No
Rnor\Rnf167
1 of 14
No
No
Mus musculus (laboratory mouse) (27)
Mmus\Birc2
9 of 14
Yes
No
Mmus\Birc3
9 of 14
Yes
No
Mmus\Xiap
7 of 14
No
No
Mmus\Birc7
6 of 14
No
No
Mmus\Birc5
2 of 14
No
No
Mmus\Birc6
2 of 14
No
No
Mmus\Naip2
2 of 14
No
No
Mmus\Naip5
2 of 14
No
No
Mmus\Gm9008
1 of 14
No
No
Mmus\Mgrn1
1 of 14
No
No
Mmus\Mib1
1 of 14
No
No
Mmus\Mylip
1 of 14
No
No
Mmus\Naip1
1 of 14
No
No
Mmus\Naip6
1 of 14
No
No
Mmus\Naip7
1 of 14
No
Yes
Mmus\Neurl1a
1 of 14
No
No
Mmus\Neurl1b
1 of 14
No
No
Mmus\Neurl2
1 of 14
No
No
Mmus\Neurl3
1 of 14
No
No
Mmus\Neurl4
1 of 14
No
No
Mmus\Rffl
1 of 14
No
No
Mmus\Rlim
1 of 14
No
No
Mmus\Rnf8
1 of 14
No
Yes
Mmus\Rnf13
1 of 14
No
No
Mmus\Rnf26
1 of 14
No
No
Mmus\Rnf157
1 of 14
No
No
Mmus\Rnf167
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (27)
Xtro\birc2
7 of 13
Yes
No
Xtro\birc7
6 of 13
No
Yes
Xtro\xiap
6 of 13
No
No
Xtro\LOC101733194
3 of 13
No
Yes
Xtro\LOC116406436
2 of 13
No
Yes
Xtro\mylip
2 of 13
No
No
Xtro\birc5l
1 of 13
No
No
Xtro\birc5
1 of 13
No
No
Xtro\birc6
1 of 13
No
No
Xtro\LOC101731001
1 of 13
No
No
Xtro\LOC108648784
1 of 13
No
Yes
Xtro\mex3a
1 of 13
No
No
Xtro\mib1
1 of 13
No
No
Xtro\naip
1 of 13
No
Yes
Xtro\neurl1
1 of 13
No
No
Xtro\neurl3
1 of 13
No
No
Xtro\neurl4
1 of 13
No
No
Xtro\rlim
1 of 13
No
No
Xtro\rnf8
1 of 13
No
Yes
Xtro\rnf26
1 of 13
No
No
Xtro\rnf34
1 of 13
No
No
Xtro\rnf145l
1 of 13
No
No
Xtro\trim2
1 of 13
No
No
Xtro\trim69.1
1 of 13
No
No
Xtro\trim69.2
1 of 13
No
No
Xtro\uhrf2
1 of 13
No
Yes
Xtro\xnf7
1 of 13
No
No
Danio rerio (Zebrafish) (30)
Drer\birc2
9 of 14
Yes
No
Drer\birc7
8 of 14
No
Yes
Drer\xiap
8 of 14
No
No
Drer\birc5b
2 of 14
No
No
Drer\birc6
2 of 14
No
No
Drer\mylipb
2 of 14
No
No
Drer\birc5a
1 of 14
No
No
Drer\cgrrf1
1 of 14
No
No
Drer\lnx1
1 of 14
No
No
Drer\lonrf1
1 of 14
No
No
Drer\lonrf1l
1 of 14
No
No
Drer\lrsam1
1 of 14
No
Yes
Drer\mex3a
1 of 14
No
No
Drer\mgrn1a
1 of 14
No
No
Drer\mgrn1b
1 of 14
No
No
Drer\mib1
1 of 14
No
No
Drer\mul1a
1 of 14
No
No
Drer\mylipa
1 of 14
No
No
Drer\neurl1aa
1 of 14
No
No
Drer\neurl1ab
1 of 14
No
No
Drer\neurl1b
1 of 14
No
No
Drer\neurl2
1 of 14
No
No
Drer\neurl4
1 of 14
No
No
Drer\rnf34b
1 of 14
No
No
Drer\rnf38
1 of 14
No
No
Drer\rnf123
1 of 14
No
No
Drer\rnf141
1 of 14
No
Yes
Drer\rnf157
1 of 14
No
No
Drer\trim35-4
1 of 14
No
Yes
Drer\zgc:171740
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (6)
Cele\bir-2
5 of 14
Yes
No
Cele\bir-1
2 of 14
No
No
Cele\exc-14
2 of 14
No
Yes
Cele\C11H1.3
1 of 14
No
No
Cele\F10D7.5
1 of 14
No
No
Cele\F16A11.1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (16)
Agam\IAP1
12 of 12
Yes
Yes
Agam\IAP3
8 of 12
No
Yes
Agam\IAP4
7 of 12
No
Yes
Agam\IAP7
7 of 12
No
Yes
Agam\AgaP_AGAP012677
4 of 12
No
Yes
Agam\IAP2
4 of 12
No
No
Agam\IAP8
4 of 12
No
Yes
Agam\AgaP_AGAP001609
2 of 12
No
No
Agam\AgaP_AGAP002651
2 of 12
No
No
Agam\IAP5
2 of 12
No
No
Agam\AgaP_AGAP000928
1 of 12
No
No
Agam\AgaP_AGAP001999
1 of 12
No
No
Agam\AgaP_AGAP005287
1 of 12
No
No
Agam\AgaP_AGAP006730
1 of 12
No
No
Agam\AgaP_AGAP009070
1 of 12
No
No
Agam\AgaP_AGAP011965
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (29)
Atha\DAL1
2 of 13
Yes
No
Atha\APD1
1 of 13
No
No
Atha\APD2
1 of 13
No
No
Atha\APD3
1 of 13
No
No
Atha\APD4
1 of 13
No
No
Atha\AT1G03365
1 of 13
No
Yes
Atha\AT1G10650
1 of 13
No
Yes
Atha\AT1G18470
1 of 13
No
Yes
Atha\AT1G32530
1 of 13
No
Yes
Atha\AT1G62370
1 of 13
No
Yes
Atha\AT1G68820
1 of 13
No
Yes
Atha\AT2G21380
1 of 13
No
No
Atha\AT2G27950
1 of 13
No
No
Atha\AT2G35330
1 of 13
No
Yes
Atha\AT3G25030
1 of 13
No
Yes
Atha\AT4G03965
1 of 13
No
Yes
Atha\AT4G13100
1 of 13
No
Yes
Atha\AT4G22250
1 of 13
No
Yes
Atha\AT4G24204
1 of 13
No
No
Atha\AT4G39050
1 of 13
No
No
Atha\AT5G04460
1 of 13
No
No
Atha\AT5G23110
1 of 13
No
Yes
Atha\BRG2
1 of 13
No
Yes
Atha\LUL2
1 of 13
No
No
Atha\LUL3
1 of 13
No
No
Atha\LUL4
1 of 13
No
No
Atha\RGLG1
1 of 13
No
Yes
Atha\XBAT34
1 of 13
No
Yes
Atha\XBAT35
1 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\BIR1
1 of 13
Yes
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\bir1
4 of 12
Yes
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Diap1. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (13)
Diap2
10 of 13
Bruce
2 of 13
Det
2 of 13
dnr1
2 of 13
CG3894
1 of 13
CG11360
1 of 13
CG17019
1 of 13
CG32369
1 of 13
mib1
1 of 13
mib2
1 of 13
Neurl4
1 of 13
neur
1 of 13
Pex10
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 2 )
    Allele
    Disease
    Evidence
    References
    Diap1UAS.cUa
    DOES NOT model  carcinoma
    CEA with EgfrUAS.cBa
    (Herranz et al., 2012)
    Diap1UAS.cHa
    model of  cancer
    CEA with hepRNAi.UAS
    (Wang et al., 2023)
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 14 )
    Allele
    Disease
    Interaction
    References
    Diap1UAS.cUa
    ameliorates  myotonic dystrophy type 1
    modeled by Zzzz\CTGi480.UAS.cGa
    (Bargiela et al., 2015)
    exacerbates  myotonic dystrophy type 1
    modeled by Zzzz\CTGi480.UAS.cGa
    (Bargiela et al., 2015)
    ameliorates  cytochrome-c oxidase deficiency disease
    modeled by ScoxGD898
    (Martínez-Morentin et al., 2015)
    ameliorates  cancer
    modeled by Hsap\CDH3UASp.cPa
    (Faria et al., 2023)
    modeled by EgfrUAS.cBa, mir-8UAS.cUa
    (Eichenlaub et al., 2016)
    DOES NOT ameliorate  cancer
    modeled by biUAS.cPa
    (Shen et al., 2014)
    ameliorates  carcinoma
    modeled by Mef2UAS.cUa, NICN.UAS
    (Pallavi et al., 2012)
    ameliorates  neurodegenerative disease
    modeled by mir-bftΔ263a-G4, mir-bft24
    (Aw et al., 2017)
    ameliorates  severe acute respiratory syndrome
    modeled by HCoV-SARS\3aUAS.CUHK-W1.EGFP
    (Wong et al., 2005)
    ameliorates  Machado-Joseph disease
    modeled by Hsap\ATXN3tr.Q78.UAS.Tag:HA
    (Raj and Sarkar, 2019, Singh et al., 2014)
    ameliorates  Coronavirus infectious disease
    modeled by HCoV-SARS\MUAS.CUHK-Su10
    (Chan et al., 2007)
    Diap1UY1835
    ameliorates  human immunodeficiency virus infectious disease
    modeled by HIV-1\VpuUAS.cLa
    (Marchal et al., 2012)
    Diap1UY1156
    ameliorates  autosomal dominant cerebellar ataxia
    modeled by Hsap\ATXN7102Q.T.UAS.Tag:NLS(SV40-largeT)
    (Latouche et al., 2007)
    Diap14
    exacerbates  Huntington's disease
    modeled by Hsap\HTT128Q.1-336.UAS
    (Branco et al., 2008)
    exacerbates  olivopontocerebellar atrophy
    modeled by Hsap\ATXN182Q.UAS
    (Branco et al., 2008)
    Diap1EP3308
    ameliorates  tauopathy
    modeled by Hsap\MAPTV337M.UAS
    (Shulman and Feany, 2003)
    Diap1EY00710
    ameliorates  autosomal dominant cerebellar ataxia
    modeled by Hsap\ATXN7102Q.T.UAS.Tag:NLS(SV40-largeT)
    (Latouche et al., 2007)
    ameliorates  retinal disease
    modeled by ninaEG69D.UAS
    (Kang et al., 2012)
    Diap1GMR.PH
    ameliorates  tauopathy
    modeled by Hsap\MAPTGMR.Ex.PJ
    (Jackson et al., 2002)
    ameliorates  Parkinson's disease
    modeled by HtrA2ΔPDZ.GMR
    (Khan et al., 2008)
    ameliorates  cancer
    modeled by AlkUAS.cLa
    (Wolfstetter et al., 2020)
    Diap1SL
    exacerbates  tauopathy
    modeled by Hsap\MAPTV337M.UAS
    (Shulman and Feany, 2003)
    Diap1UASp.cPa
    exacerbates  carcinoma
    modeled by EgfrUAS.cBa, Socs36EGD8929
    (Xu et al., 2022)
    Diap1UAS.cHa
    ameliorates  gastrointestinal adenoma
    modeled by ApcQ8, Apc2g10
    (Suijkerbuijk et al., 2016)
    ameliorates  cancer
    modeled by MycαTub84B.PBb
    (Levayer et al., 2015)
    ameliorates  Alzheimer's disease
    modeled by Tom40UAS.Tag:FLAG,Tag:HA
    (Periasamy et al., 2022)
    modeled by Hsap\APPAβ42.UAS.cUa
    (Hong et al., 2012)
    ameliorates  epilepsy
    modeled by pksple-1
    (Nukala et al., 2023)
    exacerbates  carcinoma
    modeled by Vps25N55
    (Herz et al., 2006)
    ameliorates  obesity
    modeled by ifcVDRC.cUa
    (Walls et al., 2013)
    ameliorates  human immunodeficiency virus infectious disease
    modeled by HIV-1\VpuUAS.cLa
    (Marchal et al., 2012)
    exacerbates  Alzheimer's disease 1
    modeled by Hsap\APP2xAPP.SP.UAS
    (Coelho et al., 2018)
    ameliorates  syndrome
    modeled by NSDDP00238
    (Kim et al., 2020)
    ameliorates  carcinoma
    modeled by scrib1
    (Zheng et al., 2023)
    Diap1UAS.cLa
    ameliorates  autosomal dominant cerebellar ataxia
    modeled by Hsap\ATXN182.UAS
    (Ghosh and Feany, 2004)
    modeled by Hsap\ATXN3tr.Q78.UAS.Tag:HA
    (Ghosh and Feany, 2004)
    Diap1j5C8
    exacerbates  tauopathy
    modeled by Hsap\MAPTV337M.UAS
    (Shulman and Feany, 2003)
    exacerbates  autosomal dominant cerebellar ataxia
    modeled by Hsap\ATXN7102Q.T.UAS.Tag:NLS(SV40-largeT)
    (Latouche et al., 2007)
    Diap1UAS.ORF
    ameliorates  retinitis pigmentosa 4
    modeled by ninaEP37H.UAS
    (Park et al., 2023)
    Diap1UAS.cHa.Tag:MYC
    ameliorates  Huntington's disease
    modeled by Hsap\HTT128Q.1-336.UAS
    (Branco et al., 2008)
    ameliorates  olivopontocerebellar atrophy
    modeled by Hsap\ATXN182Q.UAS
    (Branco et al., 2008)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    BIRC2; baculoviral IAP repeat containing 2
    9 of 14
    601712
        BIRC3; baculoviral IAP repeat containing 3
        9 of 14
        601721
            XIAP; X-linked inhibitor of apoptosis
            7 of 14
            300079
             
            BIRC7; baculoviral IAP repeat containing 7
            6 of 14
            605737
                 
                BIRC8; baculoviral IAP repeat containing 8
                4 of 14
                621072
                    Functional Complementation Data
                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                    Interactions
                    Summary of Physical Interactions
                    esyN Network Diagram
                    Show neighbor-neighbor interactions:
                    Show/hide secondary interactors 
                    (data from AllianceMine provided by esyN)
                    Select Layout:
                    Legend:
                    Protein
                    RNA
                    Selected Interactor(s)
                    Other Interaction Browsers
                    View in FlyBase Interactions Browser   View in MIST tool (external link)
                    Please see the Physical Interaction reports below for full details
                    protein-protein
                    Physical Interaction
                    Assay
                    References
                    Diap1
                    anti tag coimmunoprecipitation, western blot, enzymatic study
                    (Rumpf et al., 2011, Yoo, 2005)
                    Diap1 - Bruce
                    enzymatic study, western blot
                    (Yoo, 2005)
                    Diap1 - CG15141
                    anti tag coimmunoprecipitation, anti tag western blot
                    (Ditzel et al., 2008)
                    Diap1 - CG4194
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Diap1 - CtBP
                    enzymatic study, anti tag western blot, anti tag coimmunoprecipitation, peptide massfingerprinting
                    (Lee et al., 2012)
                    Diap1 - DCP1
                    anti tag coimmunoprecipitation, western blot
                    (Ditzel et al., 2008)
                    Diap1 - DUBAI
                    anti tag coimmunoprecipitation, anti tag western blot
                    (Yang et al., 2014)
                    Diap1 - Dcp-1
                    pull down, anti tag western blot, anti tag coimmunoprecipitation, western blot
                    (Leulier et al., 2006, Tenev et al., 2005)
                    Diap1 - Drice
                    pull down, anti tag western blot, molecular sieving, molecular weight estimation by staining, cleavage assay, anti tag coimmunoprecipitation, western blot
                    (Huang et al., 2014, Ditzel et al., 2008, Leulier et al., 2006, Tenev et al., 2005, Yan et al., 2004)
                    Diap1 - Dronc
                    anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot, pull down, cleavage assay, molecular weight estimation by staining, enzymatic study
                    (Liu et al., 2021, Huang et al., 2014, Rumpf et al., 2011, Ditzel et al., 2008, Dorstyn and Kumar, 2008, Means et al., 2006, Muro et al., 2005, Yan et al., 2004)
                    Diap1 - EndoG
                    anti tag coimmunoprecipitation, peptide massfingerprinting, pull down, anti tag western blot, enzymatic study
                    (Seo et al., 2014)
                    Diap1 - Erasp
                    anti tag coimmunoprecipitation, anti tag western blot, pull down
                    (Park et al., 2023)
                    Diap1 - FBXO11
                    anti tag coimmunoprecipitation, anti tag western blot
                    (Ditzel et al., 2008)
                    Diap1 - HnRNP-K
                    anti bait coimmunoprecipitation, western blot
                    (Mallik and Lakhotia, 2009)
                    Diap1 - HtrA2
                    protease assay, molecular weight estimation by staining, pull down, western blot, autoradiography
                    (Khan et al., 2008, Challa et al., 2007)
                    Diap1 - SERCA
                    anti bait coimmunoprecipitation, western blot
                    (Maurya and Tapadia, 2023)
                    Diap1 - TER94
                    anti tag coimmunoprecipitation, western blot
                    (Rumpf et al., 2011)
                    Diap1 - Ubr1
                    anti tag coimmunoprecipitation, anti tag western blot
                    (Ditzel et al., 2008)
                    Diap1 - Ubr3
                    anti tag coimmunoprecipitation, anti tag western blot, western blot
                    (Markus et al., 2023, Zanet et al., 2015, Huang et al., 2014, Ditzel et al., 2008)
                    Diap1 - eIF4E1
                    enzymatic study, anti tag western blot, anti bait coimmunoprecipitation, pull down, anti tag coimmunoprecipitation, peptide massfingerprinting
                    (Lee et al., 2007)
                    Diap1 - eff
                    pull down, autoradiography
                    (Ryoo et al., 2002)
                    Diap1 - grim
                    anti tag coimmunoprecipitation, anti tag western blot, pull down, autoradiography, molecular sieving, molecular weight estimation by staining, enzymatic study, western blot, x-ray crystallography, isothermal titration calorimetry, predetermined participant
                    (Yeh and Bratton, 2013, Khan et al., 2008, Yoo, 2005, Yan et al., 2004)
                    Diap1 - hid
                    far western blotting, anti tag western blot, pull down, western blot, isothermal titration calorimetry, predetermined participant, anti tag coimmunoprecipitation, molecular weight estimation by staining, autoradiography, molecular sieving, colocalization, fluorescence microscopy, inferred by author
                    (Morishita et al., 2013, Sandu et al., 2010, Leulier et al., 2006, Means et al., 2006, Yan et al., 2004, Ryoo et al., 2002)
                    Diap1 - hpo
                    enzymatic study, autoradiography
                    (Harvey et al., 2003, Pantalacci et al., 2003)
                    Diap1 - hyd
                    anti tag coimmunoprecipitation, anti tag western blot
                    (Ditzel et al., 2008)
                    Diap1 - morgue
                    anti tag coimmunoprecipitation, anti tag western blot, pull down, autoradiography
                    (Hays et al., 2002, Wing et al., 2002)
                    Diap1 - rdx
                    anti tag coimmunoprecipitation, anti tag western blot
                    (Liu et al., 2021)
                    Diap1 - rpr
                    isothermal titration calorimetry, predetermined participant, x-ray crystallography, pull down, anti tag western blot, autoradiography, molecular sieving, molecular weight estimation by staining, anti tag coimmunoprecipitation, western blot
                    (Thomenius et al., 2011, Sandu et al., 2010, Ditzel et al., 2008, Ribeiro et al., 2007, Tenev et al., 2005, Yan et al., 2004, Ryoo et al., 2002)
                    Summary of Genetic Interactions
                    esyN Network Diagram
                    Show/hide secondary interactors 
                    (data from AllianceMine provided by esyN)
                    esyN Network Key:
                    Suppression
                    Enhancement
                    Other Interaction Browsers
                    View in FlyBase Interactions Browser   View in MIST tool (external link)
                    Please look at the allele data for full details of the genetic interactions
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    Diap1
                    suppressible
                    AGO1
                    (Meyer et al., 2006)
                    Diap1
                    suppressible
                    AGO2
                    (Meyer et al., 2006)
                    Diap1
                    suppressible
                    Buffy
                    (Quinn et al., 2003)
                    Diap1
                    suppressible
                    Dark
                    (Sinenko, 2017, Leulier et al., 2006, Cullen and McCall, 2004, Rodriguez et al., 2002)
                    grim|Diap1
                    suppressible
                    Dark
                    (Rodriguez et al., 2002)
                    Diap1|hid
                    suppressible
                    Dark
                    (Rodriguez et al., 2002)
                    Drice|Diap1
                    suppressible
                    Dcp-1|Damm|Decay
                    (Leulier et al., 2006)
                    Diap1
                    suppressible
                    Dcr-2
                    (Meyer et al., 2006)
                    Diap1
                    suppressible
                    Diap2
                    (Ribeiro et al., 2007, Leulier et al., 2006)
                    Diap1
                    enhanceable
                    Dredd
                    (Leulier et al., 2006)
                    Diap1
                    suppressible
                    Drice
                    (Leulier et al., 2006, Muro et al., 2006)
                    Diap1
                    suppressible
                    Dronc
                    (Leulier et al., 2006, Xu et al., 2005)
                    Diap1
                    suppressible
                    eff
                    (Ryoo et al., 2002)
                    Diap1
                    enhanceable
                    Hsp60D
                    (Arya and Lakhotia, 2008)
                    Diap1
                    suppressible
                    Hsp60D
                    (Arya et al., 2010)
                    Diap1
                    suppressible
                    InR
                    (Shinoda et al., 2019)
                    Diap1|egr
                    suppressible
                    lncRNA:Hsrω
                    (Mallik and Lakhotia, 2009)
                    Diap1
                    enhanceable
                    lncRNA:Hsrω
                    (Mallik and Lakhotia, 2009)
                    Diap1
                    suppressible
                    lncRNA:Hsrω
                    (Mallik and Lakhotia, 2009)
                    rpr|Diap1
                    suppressible
                    lncRNA:Hsrω
                    (Mallik and Lakhotia, 2009)
                    Diap1
                    suppressible
                    pcm
                    (Waldron et al., 2015)
                    Diap1
                    enhanceable
                    RpS3
                    (Wada et al., 2021)
                    Diap1
                    enhanceable
                    Strica
                    (Leulier et al., 2006)
                    Diap1
                    suppressible
                    Usp15-31
                    (Sinenko, 2017)
                    Diap1
                    enhanceable
                    w
                    (Mallik and Lakhotia, 2009)
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    AIF
                    suppressible
                    Diap1
                    (Joza et al., 2008)
                    al
                    enhanceable
                    Diap1
                    (Mglinets and Ivanov, 1975)
                    aos
                    suppressible
                    Diap1
                    (Sawamoto et al., 1998)
                    ap
                    suppressible
                    Diap1
                    (Portela et al., 2010)
                    Apc2|Apc
                    suppressible
                    Diap1
                    (Suijkerbuijk et al., 2016)
                    Atg1
                    suppressible
                    Diap1
                    (Scott et al., 2007)
                    Atg1
                    enhanceable
                    Diap1
                    (Tan et al., 2024)
                    Atg8a
                    enhanceable
                    Diap1
                    (Tan et al., 2024)
                    bchs
                    suppressible
                    Diap1
                    (Müller et al., 2005)
                    bocks
                    suppressible
                    Diap1
                    (Tanaka et al., 2019)
                    caup
                    suppressible
                    Diap1
                    (Barrios et al., 2015)
                    CG5986
                    suppressible
                    Diap1
                    (Müller et al., 2005)
                    chic
                    enhanceable
                    Diap1
                    (Geisbrecht and Montell, 2004)
                    Ciao1
                    suppressible
                    Diap1
                    (Jung et al., 2020)
                    cnc
                    enhanceable
                    Diap1
                    (Tan et al., 2024)
                    cpa
                    suppressible
                    Diap1
                    (Janody and Treisman, 2006)
                    Daxx
                    suppressible
                    Diap1
                    (Hwang et al., 2013)
                    DCAF12
                    suppressible
                    Diap1
                    (Hwangbo et al., 2016)
                    Dcp-1
                    suppressible
                    Diap1
                    (Kim et al., 2010, Peterson et al., 2003)
                    Dfd
                    suppressible
                    Diap1
                    (Lohmann et al., 2002)
                    Dlg5
                    suppressible
                    Diap1
                    (Kaya-Çopur et al., 2021)
                    dome
                    suppressible
                    Diap1
                    (Recasens-Alvarez et al., 2017)
                    Dref
                    suppressible
                    Diap1
                    (Hirose et al., 2001)
                    Dronc
                    enhanceable
                    Diap1
                    (Sinenko, 2017, Wilson et al., 2002, Hawkins et al., 2000, Quinn et al., 2000)
                    Dronc
                    suppressible
                    Diap1
                    (Sinenko, 2017, Hawkins et al., 2000, Meier et al., 2000, Quinn et al., 2000)
                    DUBAI
                    suppressible
                    Diap1
                    (Yang et al., 2014)
                    E2f1
                    enhanceable
                    Diap1
                    (Morris et al., 2006)
                    ebi
                    enhanceable
                    Diap1
                    (Lim et al., 2012)
                    EcR
                    suppressible
                    Diap1
                    (Lee et al., 2019)
                    Egfr
                    suppressible
                    Diap1
                    (Herranz et al., 2012)
                    Egfr
                    enhanceable
                    Diap1
                    (Herranz et al., 2012)
                    egr
                    suppressible
                    Diap1
                    (Ma et al., 2012, Portela et al., 2010, Mallik and Lakhotia, 2009, Igaki et al., 2002, Moreno et al., 2002)
                    egr
                    enhanceable
                    Diap1
                    (Mallik and Lakhotia, 2009, Igaki et al., 2002)
                    Eip78C
                    suppressible
                    Diap1
                    (Müller et al., 2005)
                    EMC3
                    suppressible
                    Diap1
                    (Shi et al., 2023)
                    Fmr1
                    suppressible
                    Diap1
                    (Wan et al., 2000)
                    fwe
                    suppressible
                    Diap1
                    (Levayer et al., 2015)
                    grim::rpr
                    suppressible
                    Diap1
                    (Wing et al., 2001)
                    grim
                    enhanceable
                    Diap1
                    (Mallik and Lakhotia, 2009, Lisi et al., 2000)
                    grim
                    suppressible
                    Diap1
                    (Guo et al., 2003, Wing et al., 2001, Lisi et al., 2000)
                    H
                    suppressible
                    Diap1
                    (Müller et al., 2005)
                    H
                    enhanceable
                    Diap1
                    (Müller et al., 2005)
                    hep|Pvr
                    suppressible
                    Diap1
                    (Mathieu et al., 2007)
                    hid
                    suppressible
                    Diap1
                    (Wilson et al., 2002, Wing et al., 2001, Goyal et al., 2000, Lisi et al., 2000, Bergmann et al., 1998, Hay et al., 1995)
                    hid
                    enhanceable
                    Diap1
                    (Goyal et al., 2000, Lisi et al., 2000, Hay et al., 1995)
                    hpo
                    suppressible
                    Diap1
                    (Udan et al., 2003)
                    hppy
                    suppressible
                    Diap1
                    (Resnik-Docampo and de Celis, 2011)
                    HtrA2
                    suppressible
                    Diap1
                    (Khan et al., 2008)
                    Idh
                    suppressible
                    Diap1
                    (Reitman et al., 2015)
                    IKKε
                    suppressible
                    Diap1
                    (Otani et al., 2011, Oshima et al., 2006)
                    IKKε
                    enhanceable
                    Diap1
                    (Koto et al., 2009, Oshima et al., 2006)
                    InR
                    suppressible
                    Diap1
                    (Shinoda et al., 2019)
                    Ire1
                    suppressible
                    Diap1
                    (Zheng et al., 2023)
                    Ire1|scrib
                    suppressible
                    Diap1
                    (Zheng et al., 2023)
                    kibra
                    suppressible
                    Diap1
                    (Baumgartner et al., 2010)
                    kibra
                    suppressible
                    Diap1|CycE
                    (Baumgartner et al., 2010)
                    Klp10A
                    suppressible
                    Diap1
                    (Yang and Choi, 2021)
                    L
                    suppressible
                    Diap1
                    (Singh et al., 2006)
                    lig
                    suppressible
                    Diap1|CycE
                    (Baumgartner et al., 2013)
                    lig
                    suppressible
                    Diap1
                    (Baumgartner et al., 2013)
                    lin-52
                    suppressible
                    Diap1
                    (Bhaskar et al., 2014)
                    Lkb1
                    suppressible
                    Diap1
                    (Jang et al., 2008, Lee et al., 2006)
                    Lkb1|Sln
                    suppressible
                    Diap1
                    (Jang et al., 2008)
                    Lrrk
                    suppressible
                    Diap1
                    (Dodson et al., 2014)
                    Lrrk|foxo
                    enhanceable
                    Diap1
                    (Kanao et al., 2010)
                    Lsd-1
                    suppressible
                    Diap1
                    (Men et al., 2016)
                    Lsd-2
                    suppressible
                    Diap1
                    (Binh et al., 2019)
                    mbl
                    enhanceable
                    Diap1
                    (Vicente-Crespo et al., 2008)
                    mir-9a
                    suppressible
                    Diap1
                    (Bejarano et al., 2010)
                    mir-1000
                    suppressible
                    Diap1
                    (Verma et al., 2015)
                    mir-bft
                    suppressible
                    Diap1
                    (Hilgers et al., 2010)
                    morgue
                    suppressible
                    Diap1
                    (Hays et al., 2002)
                    Myc
                    suppressible
                    Diap1
                    (Levayer et al., 2015)
                    nab
                    suppressible
                    Diap1
                    (Suissa et al., 2011)
                    nanos
                    suppressible
                    Diap1
                    (Bhogal et al., 2016)
                    ninaE
                    suppressible
                    Diap1
                    (Park et al., 2023)
                    nopo
                    suppressible
                    Diap1
                    (Ma et al., 2012)
                    Ote
                    suppressible
                    Diap1
                    (Tanaka et al., 2019)
                    p53
                    suppressible
                    Diap1
                    (Simón et al., 2014)
                    parvin
                    suppressible
                    Ilk|Diap1
                    (Chountala et al., 2012)
                    parvin
                    suppressible
                    Diap1
                    (Chountala et al., 2012)
                    Patronin
                    suppressible
                    Diap1
                    (Yang and Choi, 2021)
                    pbl
                    suppressible
                    Diap1
                    (Gregory et al., 2007)
                    pbl
                    enhanceable
                    Diap1
                    (Gregory et al., 2007)
                    pcm
                    suppressible
                    Diap1
                    (Waldron et al., 2015)
                    pnut
                    enhanceable
                    Diap1
                    (Gerlach et al., 2018)
                    pnut
                    suppressible
                    Diap1
                    (Gerlach et al., 2018)
                    Prx4
                    suppressible
                    Diap1
                    (Tenev et al., 2002)
                    Psn
                    suppressible
                    Diap1
                    (Ye and Fortini, 1999)
                    puf
                    suppressible
                    Diap1
                    (Li et al., 2013)
                    pum
                    suppressible
                    Diap1
                    (Bhogal et al., 2016)
                    Pvr
                    suppressible
                    Diap1
                    (Geisbrecht and Montell, 2004)
                    Rac1
                    suppressible
                    Diap1
                    (Geisbrecht and Montell, 2004)
                    Ras85D
                    suppressible
                    Diap1
                    (Soler Beatty et al., 2021)
                    REG
                    suppressible
                    Diap1
                    (Li et al., 2015)
                    Rfx2
                    suppressible
                    Diap1
                    (Otsuki et al., 2004)
                    rpr
                    suppressible
                    Diap1
                    (Pechkovsky et al., 2013, Sandu et al., 2010, Koto et al., 2009, Mallik and Lakhotia, 2009, Ditzel et al., 2008, Igaki et al., 2002, Kuranaga et al., 2002, Lohmann et al., 2002, Tenev et al., 2002, Wing et al., 2001, Goyal et al., 2000, Lisi et al., 2000, Hay et al., 1997, Hay et al., 1995)
                    rpr
                    enhanceable
                    Diap1
                    (Mallik and Lakhotia, 2009, Tenev et al., 2002, Wilson et al., 2002, Goyal et al., 2000, Lisi et al., 2000, Hay et al., 1995)
                    rpr|hid
                    suppressible
                    Diap1
                    (Wing et al., 2001)
                    RpS3
                    enhanceable
                    Diap1
                    (Wada et al., 2021)
                    RpS3|yki
                    suppressible
                    Diap1
                    (Wada et al., 2021)
                    RYBP
                    suppressible
                    Diap1
                    (Fereres et al., 2013, González and Busturia, 2009)
                    scny
                    suppressible
                    Diap1
                    (Ribaya et al., 2009)
                    scny
                    enhanceable
                    Diap1
                    (Ribaya et al., 2009)
                    Scox
                    suppressible
                    Diap1
                    (Martínez-Morentin et al., 2015)
                    scrib
                    suppressible
                    Diap1
                    (Zheng et al., 2023)
                    SerT
                    suppressible
                    Diap1
                    (Pham et al., 2020)
                    shtd
                    enhanceable
                    Diap1
                    (Tanaka-Matakatsu et al., 2007)
                    Sin3A
                    enhanceable
                    Diap1
                    (Das et al., 2013)
                    Sirt1
                    suppressible
                    Diap1
                    (Griswold et al., 2008)
                    SkpA
                    suppressible
                    Diap1
                    (Fereres et al., 2013)
                    smash
                    suppressible
                    Diap1
                    (Tanaka et al., 2019)
                    sra
                    suppressible
                    Diap1
                    (Lee et al., 2016)
                    Srrm1
                    suppressible
                    Diap1
                    (Fan et al., 2014)
                    Stat92E
                    suppressible
                    Diap1
                    (Betz et al., 2008)
                    syd
                    suppressible
                    Diap1
                    (Ahmad et al., 2021)
                    TBPH
                    suppressible
                    Diap1
                    (Vanden Broeck et al., 2013)
                    TER94
                    suppressible
                    Diap1
                    (Rumpf et al., 2011)
                    Tom40
                    suppressible
                    Diap1
                    (Periasamy et al., 2022)
                    Traf4
                    suppressible
                    Diap1
                    (Kuranaga et al., 2002)
                    ttm50
                    enhanceable
                    Diap1
                    (Sugiyama et al., 2007)
                    Uba1
                    suppressible
                    Diap1
                    (Pfleger et al., 2007)
                    Ubqn
                    suppressible
                    Diap1
                    (Ganguly et al., 2008)
                    Usp5
                    suppressible
                    Diap1
                    (Kovacs et al., 2015)
                    vg
                    suppressible
                    Diap1
                    (Delanoue et al., 2004)
                    Vps25
                    suppressible
                    Diap1
                    (Herz et al., 2006)
                    yki
                    suppressible
                    Diap1
                    (Kaya-Çopur et al., 2021, Neto-Silva et al., 2010, Thompson and Cohen, 2006)
                    YME1L
                    suppressible
                    Diap1
                    (Qi et al., 2016)
                    External Data
                    Subunit Structure (UniProtKB)
                    Interacts (via BIR 2 domain) with Dronc (via residues 114-125) (PubMed:10675329, PubMed:10984473, PubMed:14517550). Rpr, hid and grim can outcompete Dronc for binding Diap1 therefore removing Diap1-mediated ubiquitination (PubMed:10675329, PubMed:14517550). Interacts (via BIR 2 domain) with HtrA2; this displaces any bound Dronc. Interacts with Strica (PubMed:11550090). The N-terminally cleaved form interacts with Ubr3 (via UBR-type zinc finger) (PubMed:25146930, PubMed:26383956); the interaction promotes the recruitment and uniquitination of substrate capases such as Dronc (PubMed:25146930).
                    (UniProt, Q24306 )
                    Linkouts
                    BioGRID - A database of protein and genetic interactions.
                    DroID - A comprehensive database of gene and protein interactions.
                    MIST (genetic) - An integrated Molecular Interaction Database
                    MIST (protein-protein) - An integrated Molecular Interaction Database
                    Pathways
                    Signaling Pathways (FlyBase)
                    Metabolic Pathways
                    FlyBase
                    External Links
                    External Data
                    Linkouts
                    KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                    Class of Gene
                    Genomic Location and Detailed Mapping Data
                    Chromosome (arm)
                    3L
                    Recombination map
                    3-44
                    Cytogenetic map
                    72D1-72D1
                    Sequence location
                    FlyBase Computed Cytological Location
                    Cytogenetic map
                    Evidence for location
                    72D1-72D1
                    Limits computationally determined from genome sequence between P{EP}Tfb2EP572 and P{lacW}thj5C8&P{PZ}Mbs03802
                    Experimentally Determined Cytological Location
                    Cytogenetic map
                    Notes
                    References
                    72D-72D
                    (Hay, 1996.1.5)
                    72D1-72D2
                    (determined by in situ hybridisation)
                    (Spradling et al., 1999, Hay et al., 1997)
                    72B-72B
                    (determined by in situ hybridisation)
                    (Szeged Stock Center, 1998-, Deak et al., 1997)
                    72D1-72D2
                    (BDGP Project Members, 1994-1999)
                    Experimentally Determined Recombination Data
                    Location

                    3-44

                    (FlyBase, 2016)

                    3-38.2

                    (Comeron et al., 2012)

                    3-

                    (Hay, 1996.1.5)

                    3-43.2

                    (Bishop and Sherald, 1981)
                    Left of (cM)
                    (Hjorth, 1970)
                    Right of (cM)
                    (Bentley et al., 1983)
                    (Bishop and Sherald, 1981)
                    Notes
                    Stocks and Reagents
                    Stocks (277)
                    Genomic Clones (29)
                    cDNA Clones (82)
                     

                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                    cDNA clones, fully sequenced
                    BDGP DGC clones
                    Other clones
                      Drosophila Genomics Resource Center cDNA clones

                      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                      cDNA Clones, End Sequenced (ESTs)
                      BDGP DGC clones
                      Other clones
                      RNAi and Array Information
                      Linkouts
                      DRSC - Results frm RNAi screens
                      Antibody Information
                      Laboratory Generated Antibodies
                       

                      polyclonal

                      (Li et al., 2017, Settles and Friesen, 2008, Geisbrecht and Montell, 2004, Ryoo et al., 2002)
                      Commercially Available Antibodies
                       
                      Cell Line Information
                      Publicly Available Cell Lines
                       
                        Other Stable Cell Lines
                         
                          Other Comments

                          The 'l(3)72Dc' (th) complementation group comprises 11 EMS-induced mutant alleles.

                          (Cooper and Kennison, 2011)

                          Cleaved th binds to UBR domains and promotes ubiquitination of Ice and Dcp1.

                          (Ditzel et al., 2008)

                          Gene expression is increased in response to the presence of two copies of Scer\GAL4hs.PB.

                          (Liu and Lehmann, 2008)

                          Apoptosis is induced in Kc cells that have been treated with dsRNA made from templates generated with primers directed against this gene.

                          (Colombani et al., 2006)

                          S2 cells treated with dsRNA directed against this gene show a dramatic increase in cell death.

                          (Cherry et al., 2005)

                          RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

                          (Boutros et al., 2004)

                          RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

                          (Boutros et al., 2004)

                          th has a role in promoting cell migration in border follicle cells. This effect of th on cell migration is independent of its role in preventing apoptosis, although the effect does result from inhibition of the initiator caspase Nc.

                          (Geisbrecht and Montell, 2004)

                          Loss of function mutations in th result in border follicle cell migration defects.

                          (Geisbrecht and Montell, 2004)

                          th protein is degraded by the "N-end rule" pathway and this process is indispensable for regulating apoptosis. Caspase-mediated cleavage of th protein at position 20 converts the more stable pro-N-degron of th into the highly unstable, Asn-bearing, th N-degron of the N-end rule degradation pathway.

                          (Ditzel et al., 2003)

                          dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                          (Kiger et al., 2003)

                          RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: cell number is catastrophically reduced.

                          (Kiger et al., 2003)

                          th is critical for the induction of apoptosis by rpr and W.

                          (Goyal et al., 2000)

                          rpr, W and grim may kill cells by inhibiting th's ability to antagonise caspase function.

                          (Goyal et al., 2000)

                          th is necessary to block apoptosis very early in embryonic development. This may reflect a requirement to block maternally provided rpr and W function.

                          (Lisi et al., 2000)

                          Domains in addition to the BIR2 domain of the th gene product are required for rpr, grim and W to inactivate th.

                          (Lisi et al., 2000)

                          th interacts with the pro-domain of Nc and appears to be a critical regulator of activation of Nc in vivo.

                          (Meier et al., 2000)

                          The function of the th gene is essential for cell survival.

                          (Wang et al., 1999)

                          th is epistatic to the mutant phenotype of Df(3L)H99 (deleted for rpr, W, and grim).

                          (Wang et al., 1999)

                          th promotes cell survival by blocking the activity of the Dcp-1 gene product.

                          (Wang et al., 1999)

                          The product of th can inhibit mammalian cell death induced by overexpression of caspases 1 and 2.

                          (Hawkins et al., 1998)

                          th mutants exhibit cellularization defects.

                          (Moore et al., 1998)

                          The th protein associates with the tkv receptor in vivo.

                          (Oeda et al., 1998)

                          Identification: Enhancer trap screen designed to discover genes involved in the cellular aspects of defense mechanisms, as well as in melanotic tumor formation processes linked to blood cell disregulation.

                          (Braun et al., 1997)

                          Mutations in th are dominant enhancers of rpr induced cell death.

                          (Hay et al., 1995)

                          Identified during a mutagenesis of the 71F-72D region.

                          (Melendez et al., 1995)
                          Relationship to Other Genes
                          Source for database merge of

                          Source for merge of: th l(3)S030605b l(3)S106503

                          (Szeged Stock Center, 1998-)

                          Source for merge of: th l(3)72CDe

                          (Kennison, 2008.10.30)
                          Additional comments
                          Nomenclature History
                          Source for database identify of

                          Source for identity of: Diap1 th

                          (Steller et al., 2014.7.9)
                          Nomenclature comments

                          Changed from 'th' to 'Diap1' to reflect common usage in the literature.

                          (Steller et al., 2014.7.9)
                          Etymology
                          Synonyms and Secondary IDs (67)
                          Reported As
                          Symbol Synonym
                          0736/01
                          (Deak et al., 1997)
                          1065/03
                          (Deak et al., 1997)
                          CG12284
                          (Schertel et al., 2013, Ying et al., 2011, Ni et al., 2010.12.1, Perkins et al., 2009, Chen et al., 2008, Derré et al., 2007, Quinones-Coello, 2007, Laviolette et al., 2005, Bellen et al., 2004)
                          D-IAP1
                          (Boutros et al., 2004, Kiger et al., 2003, Deveraux and Reed, 1999, Miller, 1999, Seshagiri et al., 1999, Vucic et al., 1997)
                          D-iap1
                          (Vucic et al., 1998, Vucic et al., 1998)
                          DIAP
                          (Dziedziech and Theopold, 2022, Al Hayek et al., 2021, Maurya et al., 2021, Mohammadi et al., 2020, Okumura et al., 2016, Ziraldo and Ma, 2015, Liu et al., 2013, Zhang and Cohen, 2013, Kondo et al., 2009, Jang et al., 2008, Lee et al., 2006, Gagic and Müller, 2004, Finelli et al., 2002, White, 1999)
                          DIAP I
                          (Muller et al., 2003)
                          DIAP-1
                          (Yaniv and Schuldiner, 2016, Graves et al., 2012, Szuplewski et al., 2009, Goyal et al., 2007, Edgar, 2006, Baum et al., 2005, Zheng et al., 2005, Brachmann and Cagan, 2003, Peterson et al., 2003, Jackson et al., 2002, Wang, 2001, Massagué and Chen, 2000, Zapata et al., 2000, Hawkins et al., 1998, Kaiser et al., 1998, Meier and Evan, 1998)
                          DIAP1
                          (Eslahi et al., 2024, Farodoye et al., 2024, Gao et al., 2023, Markus et al., 2023, Maurya and Tapadia, 2023, Nainu et al., 2023, Moore et al., 2022, Periasamy et al., 2022, Bawa et al., 2021, Bejarano et al., 2021, Dobens et al., 2021, Furusawa and Emoto, 2021, Harnish et al., 2021, Hounsell and Fan, 2021, Lebo and McCall, 2021, Piedade and Famulski, 2021, Schneider and Imler, 2021, Xie et al., 2021, Zarini-Gakiye et al., 2021, Banreti and Meier, 2020, Gerlach and Herranz, 2020, Hoshika et al., 2020, Mehta et al., 2020, Melamed and Kalderon, 2020, Morata and Calleja, 2020, Neal et al., 2020, Park et al., 2020, Ribeiro Lopes et al., 2020, Vissers et al., 2020, Zhuang et al., 2020, Elkholi et al., 2019, Gao et al., 2019, Jagannathan et al., 2019, Raj and Sarkar, 2019, Simoes da Silva et al., 2019, Wu et al., 2019, Bohère et al., 2018, Diwanji and Bergmann, 2018, Feng et al., 2018, Jeong et al., 2018, Khan et al., 2017, Lo Piccolo et al., 2017, Ma et al., 2017, Moon et al., 2017, Nainu et al., 2017, Nakajima and Kuranaga, 2017, Sinenko, 2017, Bhogal et al., 2016, Fallahi et al., 2016, Koerver et al., 2016, Liu et al., 2016, Men et al., 2016, Orme et al., 2016, Pinto-Teixeira et al., 2016, Poon et al., 2016, Qi et al., 2016, Suijkerbuijk et al., 2016, Yadav et al., 2016, Zhang et al., 2016, Arya and White, 2015, Bargiela et al., 2015, Barrios et al., 2015, Denton and Kumar, 2015, Di Cara et al., 2015, Dwivedi et al., 2015, Enomoto et al., 2015, Enzo et al., 2015, Huu et al., 2015, Kovacs et al., 2015, Kwon et al., 2015, Nainu et al., 2015, Reitman et al., 2015, Rojas-Ríos et al., 2015, Su, 2015, Tang et al., 2015, Verma et al., 2015, Waldron et al., 2015, Wang et al., 2015, Weng and Cohen, 2015, Zanet et al., 2015, Zhang et al., 2015, Zhang et al., 2015, Fan et al., 2014, Jeibmann et al., 2014, Mulakkal et al., 2014, Panayidou et al., 2014, Robbins et al., 2014, Santhanam et al., 2014, Seo et al., 2014, Shen et al., 2014, Simón et al., 2014, Singh et al., 2014, Yang et al., 2014, Baumgartner et al., 2013, Djiane et al., 2013, Fereres et al., 2013, Forrest et al., 2013, Guo et al., 2013, Hwang et al., 2013, Jenkins et al., 2013, Lee et al., 2013, Liu et al., 2013, Morais da Silva et al., 2013, Park et al., 2013, Rallis et al., 2013, Sidor et al., 2013, Takáts et al., 2013, Tang et al., 2013, Vanden Broeck et al., 2013, Yeh and Bratton, 2013, Yuan and Akey, 2013, Zhang and Cohen, 2013, Zhao et al., 2013, Chountala et al., 2012, Darding and Meier, 2012, Filipiak et al., 2012, Herranz et al., 2012, Kagey et al., 2012, Ma et al., 2012, Nezis, 2012, Pallavi et al., 2012, Pritchett and McCall, 2012, Vandenabeele and Bertrand, 2012, Abdelwahid et al., 2011, Gilbert et al., 2011, Kuranaga, 2011, Lee et al., 2011, Li et al., 2011, Miura, 2011, Muliyil et al., 2011, Otani et al., 2011, Rumpf et al., 2011, Shukla and Tapadia, 2011, Tao and Rolls, 2011, Vandergaast et al., 2011, Arya et al., 2010, Bader et al., 2010, Bakhrat et al., 2010, Bergmann, 2010, Broemer et al., 2010, Cordero and Cagan, 2010, Cully et al., 2010, Hilgers et al., 2010, Kanao et al., 2010, Liu et al., 2010, Malzer et al., 2010, Milton et al., 2010, Neto-Silva et al., 2010, Nezis et al., 2010, Sandu et al., 2010, Yang et al., 2010, Yavari et al., 2010, Bedoukian et al., 2009, Chew et al., 2009, Genevet et al., 2009, González and Busturia, 2009, Grieder et al., 2009, Hamaratoglu et al., 2009, Hong et al., 2009, Kessler and Müller, 2009, Koto et al., 2009, Lee et al., 2009, Mallik and Lakhotia, 2009, Ribaya et al., 2009, Shen et al., 2009, Szuplewski et al., 2009, Zhang et al., 2009, Arya and Lakhotia, 2008, Bardet et al., 2008, Bejarano et al., 2008, Branco et al., 2008, Caldwell et al., 2008, Ditzel et al., 2008, Freel et al., 2008, Griswold et al., 2008, Khan et al., 2008, Li and Cadigan, 2008, Martin et al., 2008, Mehrotra et al., 2008, Sato et al., 2008, Zhao et al., 2008, Abdelwahid et al., 2007, Baum et al., 2007, Caldwell and Eberl, 2007, Challa et al., 2007, Chandraratna et al., 2007, Chan et al., 2007, Chou et al., 2007, Guan et al., 2007, Harvey and Bennett, 2007, Herman-Bachinsky et al., 2007, Igaki et al., 2007, Koto et al., 2007, Kuranaga and Miura, 2007, Lannan et al., 2007, Latouche et al., 2007, Lee et al., 2007, Link et al., 2007, Maier et al., 2007, Mathieu et al., 2007, Pellock et al., 2007, Pfleger et al., 2007, Polesello and Tapon, 2007, Reuveny and Volk, 2007, Ribeiro et al., 2007, Sasaki et al., 2007, Scott et al., 2007, Scott et al., 2007, Song et al., 2007, Sugiyama et al., 2007, Wu et al., 2007, Yi et al., 2007, Yin et al., 2007, Adrain, 2006, Awasaki et al., 2006, Brun et al., 2006, Colombani et al., 2006, Colombani et al., 2006, Hamaratoglu et al., 2006, Hamaratoglu et al., 2006, Hays, 2006, Ho et al., 2006, Janody and Treisman, 2006, Kondo et al., 2006, Kuo et al., 2006, Kuranaga et al., 2006, Leulier et al., 2006, Means et al., 2006, Meyer et al., 2006, Montell, 2006, Müller et al., 2006, Oshima, 2006, Oshima et al., 2006, Thompson and Cohen, 2006, Vidal and Cagan, 2006, Williams et al., 2006, Abdelwahid et al., 2005, Adachi-Yamada et al., 2005, Anderson et al., 2005, Gagic et al., 2005, Gesellchen et al., 2005, Guan et al., 2005, Kanuka et al., 2005, Kornbluth and White, 2005, Lai et al., 2005, Müller et al., 2005, Muro et al., 2005, Tenev et al., 2005, Tomioka et al., 2005, Wech and Nagel, 2005, Wong et al., 2005, Coffman, 2004, Danial and Korsmeyer, 2004, Delanoue et al., 2004, Dotto and Silke, 2004, Geisbrecht and Montell, 2004, Harvey et al., 2004, Hays, 2004, Huh et al., 2004, Huh et al., 2004, Igaki and Miura, 2004, Jia et al., 2004, Kessler and Müller, 2004, Levine, 2004, Otsuki et al., 2004, Ryoo et al., 2004, Shiozaki and Shi, 2004, Udan et al., 2004, Varfolomeev and Ashkenazi, 2004, Wheeler et al., 2004, Xu et al., 2004, Yan et al., 2004, Yeo and Gautier, 2004, Yokokura et al., 2004, Yokokura et al., 2004, Bach et al., 2003, Ditzel et al., 2003, Gagic and Muller, 2003, Giot et al., 2003, Guo et al., 2003, Harvey et al., 2003, Hay and Guo, 2003, Hidalgo and ffrench-Constant, 2003, Hu and Yang, 2003, Ilangovan et al., 2003, Jaklevic and Su, 2003, Jia et al., 2003, Kessler and Muller, 2003, Kuranaga et al., 2003, Meier and Silke, 2003, Moberg and Hariharan, 2003, Morey et al., 2003, Morey et al., 2003, Nijhout, 2003, Olson et al., 2003, Olson et al., 2003, Ou et al., 2003, Pantalacci, 2003, Pantalacci et al., 2003, Rothenberg and Jan, 2003, Schreader et al., 2003, Udan et al., 2003, Varshavsky, 2003, Yokokura et al., 2003, Zachariou et al., 2003, Abrams, 2002, Alonso, 2002, Gozani et al., 2002, Hays et al., 2002, Holcik, 2002, Holley et al., 2002, Huh and Hay, 2002, Igaki et al., 2002, Jackson et al., 2002, Kuranaga et al., 2002, Luque et al., 2002, Martin, 2002, Moreno et al., 2002, Palaga and Osborne, 2002, Ryoo et al., 2002, Srinivasula et al., 2002, Srinivasula et al., 2002, Tapon et al., 2002, Tenev et al., 2002, Wilson et al., 2002, Wing et al., 2002, Wright and Clem, 2002, Yoo et al., 2002, Yu et al., 2002, Zimmermann et al., 2002, Bangs et al., 2001, Doumanis et al., 2001, Hirose et al., 2001, Silke and Vaux, 2001, Wu et al., 2001, Hawkins et al., 2000, Jones et al., 2000, Lisi et al., 2000, Meier et al., 2000, Meier et al., 2000, Reed and Bischoff, 2000, Steller, 2000, Takatsu et al., 2000, Vernooy et al., 2000, Vernooy et al., 2000, Vernooy et al., 2000, Abrams, 1999, Hawkins et al., 1999, Song and Steller, 1999, Song and Steller, 1999, Song and Steller, 1999, Vaux and Korsmeyer, 1999, Wang et al., 1999, Ye and Fortini, 1999, Bergmann et al., 1998, Foley and Cooley, 1998, LaCasse et al., 1998, Oeda et al., 1998, Wing and Nambu, 1998, Clem and Duckett, 1997, Harvey et al., 1997, McCall and Steller, 1997, Chinnaiyan and Dixit, 1996, Hay, 1996.1.5, Hay et al., 1995)
                          DIAPI
                          (Anderson et al., 2005)
                          DIAp
                          (Lakhotia, 2017)
                          DiAP1
                          (Rui, 2024)
                          Diap
                          (Xu et al., 2021, Campbell et al., 2018, Cruz et al., 2018, Kim and Jho, 2018, Lu et al., 2013, Tran et al., 2013, Classen et al., 2009)
                          Diap-1
                          (Wang et al., 2022, Gangwani et al., 2020, Sorrentino et al., 2014, Christiansen et al., 2013, Lawrence and Casal, 2013, Mislak et al., 2007, Cagan, 2003, Lawen, 2003, Hays et al., 2002, Wells, 2002)
                          Diap-1/Th
                          (Moskalev, 2001)
                          Diap1
                          (Jang et al., 2024, Luo et al., 2024, Nguyen et al., 2024, Portela et al., 2024, Umargamwala et al., 2024, Cachoux et al., 2023, Dou et al., 2023, Faria et al., 2023, Golubev et al., 2023, Heigwer et al., 2023, Huang et al., 2023, Kim et al., 2023, Neophytou et al., 2023, Petsakou et al., 2023, Shi et al., 2023, Suyama et al., 2023, Taniguchi and Igaki, 2023, Yamada et al., 2023, Zheng et al., 2023, Almeida Machado Costa et al., 2022, Baonza et al., 2022, Colon-Plaza and Su, 2022, Feng et al., 2022, Gera et al., 2022, Hu et al., 2022, Jia et al., 2022, Kong et al., 2022, Li et al., 2022, Liu et al., 2022, Schroeder et al., 2022, Tarikere et al., 2022, Valencia-Expósito et al., 2022, Xu et al., 2022, Yang et al., 2022, Yang et al., 2022, Ahmad et al., 2021, Bordet et al., 2021, Buhlman et al., 2021, DeAngelis et al., 2021, Fan et al., 2021, Gogia et al., 2021, Liu et al., 2021, Millet-Boureima et al., 2021, Russell et al., 2021, Savadogo et al., 2021, Soler Beatty et al., 2021, Wada et al., 2021, Yang and Choi, 2021, Zhang et al., 2021, Ai et al., 2020, Fujisawa et al., 2020, Gou et al., 2020, Guo et al., 2020, Jeon et al., 2020, Jevitt et al., 2020, Jung et al., 2020, Kidera et al., 2020, Krautz et al., 2020, La Marca and Richardson, 2020, Perez-Gomez et al., 2020, Singh et al., 2020, Sun et al., 2020, van Soldt and Cardoso, 2020, Walls et al., 2020, Wang and Spradling, 2020, Wang et al., 2020, Xu et al., 2020, Domingos et al., 2019, Herrera and Bach, 2019, Khan et al., 2019, Kockel et al., 2019, Liu et al., 2019, Meltzer et al., 2019, Merkling et al., 2019, Moreno et al., 2019, Nan et al., 2019, Nelson et al., 2019, Singh et al., 2019, Skouloudaki et al., 2019, Tanaka et al., 2019, Tsogtbaatar et al., 2019, Wang and Baker, 2019, Xu et al., 2019, Yee et al., 2019, Ahmed-de-Prado and Baonza, 2018, Azuma et al., 2018, Baena-Lopez et al., 2018, Baker et al., 2018, Campbell et al., 2018, Cong et al., 2018, Dubey and Tapadia, 2018, Richardson and Portela, 2018, Sander et al., 2018, Xu et al., 2018, Aw et al., 2017, Garcia-Garcia et al., 2017, Li et al., 2017, Schott et al., 2017, Shu and Deng, 2017, Tavignot et al., 2017, Torres et al., 2017, Transgenic RNAi Project members, 2017-, Chan et al., 2016, Dabrowska et al., 2016, Deng et al., 2016, Diaz-Garcia et al., 2016, Eichenlaub et al., 2016, Eroglu and Derry, 2016, Huang et al., 2016, Hwangbo et al., 2016, Jenny and Basler, 2016, Kockel et al., 2016, Kuleesha et al., 2016, Lee et al., 2016, Lee et al., 2016, Nakazawa et al., 2016, Bae et al., 2015, Cao et al., 2015, Kolahgar et al., 2015, Li et al., 2015, Martínez-Morentin et al., 2015, Means et al., 2015, Meserve and Duronio, 2015, Nicolson et al., 2015, Sakamaki et al., 2015, Wang and Baker, 2015, Zhang et al., 2015, Zheng et al., 2015, Zimmermann et al., 2015, Bhaskar et al., 2014, Ferguson and Martinez-Agosto, 2014, Huang et al., 2014, Martorell et al., 2014, Netter, 2014.2.26, Rauskolb et al., 2014, Steller et al., 2014.7.9, Baumgartner et al., 2013, Das and Cagan, 2013, Das et al., 2013, Das et al., 2013, Degoutin et al., 2013, Denton et al., 2013, Dick and Megeney, 2013, Hirabayashi et al., 2013, Huang et al., 2013, Jin et al., 2013, Koontz et al., 2013, Levayer and Moreno, 2013, Li et al., 2013, Liu et al., 2013, Oh et al., 2013, Rallis et al., 2013, Yacobi-Sharon et al., 2013, Yin et al., 2013, Yu et al., 2013, Etchegaray et al., 2012, Fabian and Brill, 2012, Florentin and Arama, 2012, Foronda et al., 2012, Hafezi et al., 2012, Lee et al., 2012, Lim et al., 2012, Miura, 2012, Pushpavalli et al., 2012, Chan et al., 2011, Miles et al., 2011, Morata et al., 2011, Rauskolb et al., 2011, Reddy and Irvine, 2011, Suissa et al., 2011, Thomenius et al., 2011, Winbush and Weeks, 2011, Zhang et al., 2011, Baumgartner et al., 2010, Bejarano et al., 2010, Reddy et al., 2010, Mao et al., 2009, Oh and Irvine, 2009, Oh et al., 2009, Reuveny et al., 2009, Romani et al., 2009, Wang and Kalderon, 2009, Xu et al., 2009, Joza et al., 2008, Lee et al., 2008, Pret et al., 2008, Protzer et al., 2008, Rogulja et al., 2008, Shapiro and Ryoo, 2008, Vicente-Crespo et al., 2008, Arama et al., 2007, Dong et al., 2007, Lee et al., 2007, Tenev et al., 2007, Vicente et al., 2007, Volk and Reuveny, 2007, Baehrecke, 2006, Bergmann, 2006, Cho et al., 2006, Herz, 2006, Herz et al., 2006, Silva, 2006, Silva et al., 2006, Wells et al., 2006, Yoo, 2005, Hsu et al., 2004, Kumar and Cakouros, 2004, Baehrecke, 2003, Claveria and Torres, 2003, Jassim et al., 2003, Kramer et al., 2003, Rodriguez et al., 2002, Harvey et al., 2001, Chen and Abrams, 2000, Kumar, 2000, Uren et al., 1998)
                          E(rpr)3-1
                          E3
                          (Bergmann, 2010)
                          IAP
                          (Liu et al., 2013, Tyler and Baker, 2007, Adachi-Yamada et al., 2005, Nakayama et al., 2000, Conlan and Raff, 1999)
                          IAP1
                          (Hou et al., 2016, Enchev et al., 2015, Yang et al., 2013, Sandu et al., 2010, Chew et al., 2009, Gregory et al., 2007, Latouche et al., 2007)
                          Iap
                          (Saha et al., 2022)
                          Iap1
                          (Liu et al., 2009)
                          S048915
                          (Link et al., 2007)
                          TH
                          (Song et al., 2013)
                          Thread
                          (Moy et al., 2014)
                          dIAP
                          (He et al., 2017, Resnik-Docampo et al., 2017, Diaz-Garcia et al., 2016, Flegel et al., 2016, Losick et al., 2013, Zhan et al., 2013, Jones et al., 2012, Jones et al., 2008, White, 2000)
                          dIAP-1
                          (Jones et al., 2012, Rhiner et al., 2009, Li et al., 2002, Lisi et al., 1998)
                          dIAP1
                          (Sollazzo et al., 2022, Lee and Park, 2021, López-Gay et al., 2020, Baillon et al., 2018, Walls et al., 2018, Recasens-Alvarez et al., 2017, Bielmeier et al., 2016, Casas-Tintó et al., 2016, Grifoni et al., 2015, Wu et al., 2015, Fan et al., 2014, Pechkovsky et al., 2013, Walls et al., 2013, Domingues and Ryoo, 2012, Gistelinck et al., 2012, Froldi et al., 2010, Mesquita et al., 2010, Portela et al., 2010, Rhiner et al., 2010, Rimkus et al., 2008, Tsujimura et al., 2008, Morris et al., 2006, Saleh et al., 2006, Wang et al., 2006, Secombe et al., 2004, Bangs et al., 2000, Kurada and White, 1998)
                          dIap1
                          (Wu and Silverman, 2007)
                          diap
                          (Kumar and Baker, 2022, Verghese and Su, 2016, Organista and De Celis, 2013, Resnik-Docampo and de Celis, 2011, Silva, 2006)
                          diap 1
                          (Liu et al., 2012, Silva, 2006)
                          diap-1
                          (Ferguson et al., 2021, Mehta et al., 2020, Ojha and Tapadia, 2020, Xu et al., 2018, Creagh et al., 2009, Baena-Lopez et al., 2008, Tanner et al., 2008, Edgar, 2006, Mazzalupo and Cooley, 2006, Peterson et al., 2006, Schuldt, 2000)
                          diap1
                          (Li et al., 2024, Matamoro-Vidal et al., 2024, Sun et al., 2024, Heron et al., 2023, Ding et al., 2022, Gao et al., 2022, Merino et al., 2022, Ding et al., 2021, Liu et al., 2021, Srivastava et al., 2021, Bajpai et al., 2020, Blanco et al., 2020, Gogia et al., 2020, Skouloudaki et al., 2020, Tafesh-Edwards and Eleftherianos, 2020, Yeom et al., 2020, Yu et al., 2020, Binh et al., 2019, Guo et al., 2019, Kim et al., 2019, Lee et al., 2019, Ma et al., 2019, Pinal et al., 2019, Sun et al., 2019, Cho et al., 2018, Katsukawa et al., 2018, Moon et al., 2018, Xu et al., 2018, Kamber Kaya et al., 2017, Lu et al., 2017, Martín et al., 2017, Napoletano et al., 2017, Smart et al., 2017, Wang et al., 2017, Zhang et al., 2017, Barron and Moberg, 2016, Chung et al., 2016, Willsey et al., 2016, Dong et al., 2015, Levayer et al., 2015, Means et al., 2015, Parker and Struhl, 2015, Xing et al., 2015, Zhang et al., 2015, Dodson et al., 2014, Huang and Kalderon, 2014, Ihry and Bashirullah, 2014, Ikmi et al., 2014, Qing et al., 2014, Andersen et al., 2013, Enderle and McNeill, 2013, Geisbrecht et al., 2013, Herrera et al., 2013, Hirabayashi et al., 2013, Huang et al., 2013, Kanda et al., 2013, Koontz et al., 2013, Lee et al., 2013, Liu et al., 2013, Oh et al., 2013, Perea et al., 2013, Schertel et al., 2013, Yacobi-Sharon et al., 2013, Etchegaray et al., 2012, Fausti et al., 2012, Herranz et al., 2012, Ihry et al., 2012, Liu et al., 2012, Marchal et al., 2012, Marinari et al., 2012, Meier et al., 2012, Poernbacher et al., 2012, Verghese et al., 2012, Yue et al., 2012, Fernández et al., 2011, Gafuik and Steller, 2011, Genevet and Tapon, 2011, Khammari et al., 2011, Laprise, 2011, Lee et al., 2011, Richter et al., 2011, Sun et al., 2011, Yan et al., 2011, Zhao et al., 2011, Baumgartner et al., 2010, Benitez et al., 2010, Chen et al., 2010, Das Thakur et al., 2010, Genevet et al., 2010, Grzeschik et al., 2010, Ling et al., 2010, Matova and Anderson, 2010, Menéndez et al., 2010, Nicolay et al., 2010, Robinson et al., 2010, Sekyrova et al., 2010, Shaw et al., 2010, Wang et al., 2010, Yu et al., 2010, Chittaranjan et al., 2009, Creagh et al., 2009, Doumanis et al., 2009, Kondo et al., 2009, Martín et al., 2009, Ohayon et al., 2009, Umemori et al., 2009, Betz et al., 2008, Dorstyn and Kumar, 2008, Dutta and Baehrecke, 2008, Ganguly et al., 2008, Settles and Friesen, 2008, Shapiro et al., 2008, Shimizu et al., 2008, Wang et al., 2008, Willecke et al., 2008, Wu et al., 2008, Yu et al., 2008, Zhang et al., 2008, Zhang et al., 2008, Betz et al., 2007, Copeland et al., 2007, Gregory et al., 2007, Hamaratoglu et al., 2007, Huh et al., 2007, Peterson et al., 2007, Primrose et al., 2007, Ribeiro et al., 2007, Tanaka-Matakatsu et al., 2007, Yin et al., 2007, Yoneda et al., 2007, Bashirullah et al., 2006, Choi et al., 2006, Leulier et al., 2006, Montell, 2006, Nolo et al., 2006, Singh et al., 2006, Vidal et al., 2006, Xu et al., 2006, Xu et al., 2006, Huang et al., 2005, Xu et al., 2005, Xu et al., 2005, Hay et al., 2004, Muro et al., 2004, Ryoo et al., 2004, Yin and Thummel, 2004, Yin et al., 2004, Bergmann et al., 2003, Ryoo and Steller, 2003, Yin and Thummel, 2003, Ditzel and Meier, 2002, Gorski and Marra, 2002, Igaki et al., 2002, Muro et al., 2002, Ryoo et al., 2002, Wing et al., 2001, Bialik and Gottlieb, 2000, Buszczak and Segraves, 2000, Colussi et al., 2000, Goyal et al., 2000, Hsu and Schulz, 2000, Kumar and Doumanis, 2000, Pecasse et al., 2000, Quinn et al., 2000, Tittel and Steller, 2000, Agapite et al., 1999, Kanuka et al., 1999, White et al., 1999, Bergmann et al., 1998, Sawamoto et al., 1998, Jiang et al., 1997)
                          diap1/thread
                          (Richardson and Kumar, 2002)
                          l(3)72CDe
                          (Cooper and Kennison, 2011, Kennison, 2008.10.30)
                          l(3)72Dc
                          (Cooper and Kennison, 2011)
                          l(3)S030605
                          l(3)S030605b
                          (Szeged Stock Center, 1998-)
                          l(3)S106503
                          l(3)j5C8
                          (Braun et al., 1997)
                          th
                          (McSharry and Beitel, 2019, Shinoda et al., 2019, Mondal et al., 2018, Stephano et al., 2018, Wang et al., 2018, Chan et al., 2017, Ruppert et al., 2017, Mao et al., 2016, Bunker et al., 2015, Doggett et al., 2015, Kwon et al., 2015, Merkling et al., 2015, Zhang et al., 2015, Faisal et al., 2014, Merlo et al., 2014, Robbins et al., 2014, Bonke et al., 2013, Degoutin et al., 2013, Djiane et al., 2013, Hirabayashi et al., 2013, Lee et al., 2013, Lindsley et al., 2013, Lu et al., 2013, Ryoo, 2013.7.26, Schertel et al., 2013, Chakrabarti et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Kang et al., 2012, Zhai et al., 2012, Cooper and Kennison, 2011, Du et al., 2011, Gilbert et al., 2011, Johnson et al., 2011, Khammari et al., 2011, Rauskolb et al., 2011, Reddy and Irvine, 2011, Rumpf et al., 2011, Winbush and Weeks, 2011, Arya et al., 2010, Kim et al., 2010, Matova and Anderson, 2010, Milton et al., 2010, Sakurai et al., 2010, Chew et al., 2009, Kessler and Müller, 2009, Kondo et al., 2009, Koto et al., 2009, Ohayon et al., 2009, Ribaya et al., 2009, Branco et al., 2008, Chen et al., 2008, Garcia-Lopez et al., 2008, Hou et al., 2008, Oh and Irvine, 2008, Vicente-Crespo et al., 2008, Wang et al., 2008, Zhang et al., 2008, Chandraratna et al., 2007, Derré et al., 2007, Guan et al., 2007, Lai et al., 2007, Latouche et al., 2007, Link et al., 2007, Mislak et al., 2007, Pfleger et al., 2007, Quinones-Coello, 2007, Tanaka-Matakatsu et al., 2007, Balakireva et al., 2006, Cho et al., 2006, Janody and Treisman, 2006, Kuo et al., 2006, Morris et al., 2006, Muro et al., 2006, Laviolette et al., 2005, Terashima and Bownes, 2005, Wech and Nagel, 2005, Delanoue et al., 2004, Ghosh and Feany, 2004, Moskalev and Zainullin, 2004, Renault et al., 2004, Takahashi and Ting, 2004)
                          thread
                          (Mishra-Gorur et al., 2019, Gistelinck et al., 2012, Cowan et al., 2011, Cho et al., 2006)
                          Name Synonyms
                          DIAP1
                          (Bardet et al., 2008, Bennett and Harvey, 2006, Willecke et al., 2006)
                          Death-associated inhibitor of apoptosis 1
                          (Steller et al., 2014.7.9)
                          Drosophila IAP1
                          (Koto et al., 2009, Morey et al., 2003)
                          Drosophila Inhibitor of Apoptosis
                          (Liu et al., 2013, Mislak et al., 2007)
                          Drosophila Inhibitor of Apoptosis 1
                          (Ditzel et al., 2008, Chou et al., 2007)
                          Drosophila Inhibitor of Apoptosis Protein
                          (Zhang and Cohen, 2013, Janody and Treisman, 2006)
                          Drosophila Inhibitor of Apoptosis Protein 1
                          (Kwon et al., 2015, Walls et al., 2013, Mallik and Lakhotia, 2009)
                          Drosophila Inhibitor of Apoptosis Protein-1
                          (Szuplewski et al., 2009)
                          Drosophila Inhibitor of apoptosis protein 1
                          (Reddy et al., 2010, Li and Cadigan, 2008)
                          Drosophila inhibitor of apoptosis
                          (Kim and Jho, 2018, Di Cara et al., 2015, Fabian and Brill, 2012, Branco et al., 2008, Caldwell and Eberl, 2007, Edgar, 2006, Wheeler et al., 2004)
                          Drosophila inhibitor of apoptosis 1
                          (Levayer and Moreno, 2013, Das Thakur et al., 2010, Grzeschik et al., 2010, Milton et al., 2010, Robinson et al., 2010, Betz et al., 2008, Caldwell et al., 2008, Rimkus et al., 2008, Lee et al., 2007, Yi et al., 2007, Yin et al., 2007, Baehrecke, 2006, Montell, 2006)
                          Drosophila inhibitor of apoptosis protein
                          (Shukla and Tapadia, 2011)
                          Drosophila inhibitor of apoptosis protein 1
                          (Kawamoto et al., 2016, Rhiner et al., 2010, Wech and Nagel, 2005, Moreno et al., 2002)
                          Drosophila inhibitor-of-apoptosis protein 1
                          (Adrain, 2006)
                          Drosophila thread/inhibitor of apoptosis protein-1
                          (Morris et al., 2006)
                          Inhibitor of Apoptosis 1
                          (Forrest et al., 2013, Froldi et al., 2010, Genevet et al., 2010)
                          Inhibitor of Apoptosis Protein 1
                          (Umemori et al., 2009)
                          Inhibitor of apoptosis 1
                          Inhibitors of Apoptosis protein
                          (Guan et al., 2005)
                          Thread
                          (Liu et al., 2009)
                          degradation of inhibitors of apoptosis
                          (Cordero and Cagan, 2010)
                          diap1
                          (Willecke et al., 2006)
                          drosophila inhibitor of apoptosis protein
                          (Garcia-Lopez et al., 2008)
                          inhibitor of apoptosis
                          (Nicolay et al., 2010, Jones et al., 2008)
                          inhibitor of apoptosis protein 1
                          (Lee et al., 2011, Portela et al., 2010, Bardet et al., 2008)
                          inhibitor of apoptosis-1
                          (Morris et al., 2006)
                          inhibitor of apoptotic protein 1
                          (Lee et al., 2013)
                          lethal (3) 72CDe
                          (Melendez et al., 1995)
                          thread
                          (Jonchère et al., 2017, Merkling et al., 2015, Faisal et al., 2014, Robbins et al., 2014, Degoutin et al., 2013, Lee et al., 2013, Lu et al., 2013, Garcia et al., 2012, Rauskolb et al., 2011, Winbush and Weeks, 2011, Arya et al., 2010, Cordero and Cagan, 2010, Kim et al., 2010, Milton et al., 2010, Martín et al., 2009, Bardet et al., 2008, Branco et al., 2008, Garcia-Lopez et al., 2008, Hoopfer et al., 2008, Liu and Lehmann, 2008, Oh and Irvine, 2008, Sathyanarayanan et al., 2008, Shapiro and Ryoo, 2008, Chandraratna et al., 2007, Gregory et al., 2007, Guan et al., 2007, Lai et al., 2007, Link et al., 2007, Mislak et al., 2007, Cho et al., 2006, Morris et al., 2006, Musters et al., 2006, Terashima and Bownes, 2005, Takahashi and Ting, 2004, Moreno et al., 2002)
                          Secondary FlyBase IDs
                          • FBgn0016903
                          • FBgn0003691
                          • FBgn0011383
                          • FBgn0015246
                          • FBgn0046835
                          • FBgn0046836
                          Datasets (0)
                          Study focus (0)
                          Experimental Role
                          Project
                          Project Type
                          Title
                          Study result (0)
                          Result
                          Result Type
                          Title
                          External Crossreferences and Linkouts ( 94 )
                          Sequence Crossreferences
                          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                          Other crossreferences
                          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                          InterPro - A database of protein families, domains and functional sites
                          KEGG Genes - Molecular building blocks of life in the genomic space.
                          MARRVEL_MODEL - MARRVEL (model organism gene)
                          PDB - An information portal to biological macromolecular structures
                          Linkouts
                          BioGRID - A database of protein and genetic interactions.
                          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                          DroID - A comprehensive database of gene and protein interactions.
                          DRSC - Results frm RNAi screens
                          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                          Flygut - An atlas of the Drosophila adult midgut
                          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                          MIST (genetic) - An integrated Molecular Interaction Database
                          MIST (protein-protein) - An integrated Molecular Interaction Database
                          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                          SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                          References (1,164)