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General Information
Symbol
Dmel\Diap1
Species
D. melanogaster
Name
Death-associated inhibitor of apoptosis 1
Annotation Symbol
CG12284
Feature Type
FlyBase ID
FBgn0260635
Gene Model Status
Stock Availability
Gene Snapshot
Death-associated inhibitor of apoptosis 1 (Diap1) encodes an E3 ubiquitin ligase with a caspase inhibitor activity that is involved in the control of apoptosis. [Date last reviewed: 2019-03-07]
Also Known As

th, thread, DIAP-1, Drosophila inhibitor of apoptosis 1, DIAP

Key Links
Genomic Location
Cytogenetic map
Sequence location
3L:16,038,410..16,051,034 [-]
Recombination map

3-44

RefSeq locus
NT_037436 REGION:16038410..16051034
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (38 terms)
Molecular Function (12 terms)
Terms Based on Experimental Evidence (10 terms)
CV Term
Evidence
References
inferred from physical interaction with FLYBASE:Dcp-1; FB:FBgn0010501
inferred from physical interaction with FLYBASE:Drice; FB:FBgn0019972
inferred from direct assay
inferred from physical interaction with FLYBASE:IKKε; FB:FBgn0086657
inferred from physical interaction with FLYBASE:hid; FB:FBgn0003997
inferred from physical interaction with FLYBASE:rpr; FB:FBgn0011706
inferred from physical interaction with FLYBASE:Dcp-1; FB:FBgn0010501
inferred from physical interaction with UniProtKB:Q9VFJ3
(assigned by UniProt )
inferred from physical interaction with FLYBASE:Jafrac2; FB:FBgn0040308
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000005168
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000799425
(assigned by GO_Central )
traceable author statement
(assigned by UniProt )
inferred from sequence model
Biological Process (22 terms)
Terms Based on Experimental Evidence (21 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from physical interaction with FLYBASE:hid; FB:FBgn0003997
inferred from physical interaction with FLYBASE:rpr; FB:FBgn0011706
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Rac1; FB:FBgn0010333
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from direct assay
inferred from genetic interaction with FLYBASE:hid; FB:FBgn0003997
inferred from genetic interaction with FLYBASE:rpr; FB:FBgn0011706
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Dcp-1; FB:FBgn0010501
inferred from genetic interaction with FLYBASE:Drice; FB:FBgn0019972
inferred from direct assay
inferred from genetic interaction with FLYBASE:Dronc; FB:FBgn0026404
inferred from genetic interaction with FLYBASE:Dark; FB:FBgn0263864
inferred from mutant phenotype
(assigned by UniProt )
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000005168
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000799425
(assigned by GO_Central )
Cellular Component (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000005166
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000005166
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000005168
(assigned by GO_Central )
Protein Family (UniProt)
Belongs to the IAP family. (Q24306)
Summaries
Gene Group (FlyBase)
INHIBITOR OF APOPTOSIS UBIQUITIN LIGASES -
E3 (ubiquitin) ligases interact with both ubiquitin-E2 (ubiquitin-conjugating) enzymes and the target protein, transferring the ubiquitin from the E2 to the substrate. Inhibitor of APoptosis (IAP) ubiquitin ligases are defined by the presence of one or more BIR (baculoviral IAP repeat) and a UBA (ubiquitin (Ub)-associated domain) domain that binds polyubiquitin and a RING finger domain. (Adapted from FBrf0216918).
INHIBITOR OF APOPTOSIS -
Inhibitor of APoptosis (IAP) proteins are defined by the presence of one or more BIR (baculoviral IAP repeat) domains. Not all IAPs inhibit apoptosis, but some interact with and inhibit caspases via their BIR domains. This interaction is displaced by RHG protein binding. (Adapted from FBrf0215539).
NEDD8 TRANSFERASES -
NEDD8 transferases catalyse the transfer of the ubiquitin-like protein NEDD8 from one substrate to another. They include NEDD8 conjugating (E2) enzymes and NEDD8 ligase (E3) enzymes, which act sequentially in a process analogous to ubiquitination, and result in covalent attachment of NEDD8 to target proteins. Neddylation results in activation of members of the cullin-RING family of ubiquitin E3 ligases, which appear to be the major NEDD8 targets in the cell. (Adapted from PMID:25531226.)
Protein Function (UniProtKB)
Anti-apoptotic protein which functions as a caspase regulator, using its E3 ubiquitin-protein ligase activity to smother caspase activity. Binds, ubiquitinates and inactivates initiator caspase Dronc, and effector caspases Drice and Dcp-1. Acts as a Nedd8-E3 ubiquitin-protein ligase for Drice. Suppresses apoptosis by targeting the apoptosome for ubiquitination and inactivation. Plays an important role in cell motility. Overexpression suppresses rpr and hid-dependent cell death in the eye. Interaction of Diap1 with Dronc is required to suppress Dronc-mediated cell death through Diap1-mediated ubiquitination of Dronc. Acts as a positive regulator of Wnt signaling.
(UniProt, Q24306)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
th: thread
Aristae threadlike, without side branches. Mutation affects development of tarsal claws at 29 (Mglinetz and Ivanov, 1975). Deficiency for th homozygous lethal (Ward and Alexander, 1957; Korge, 1972). Mutant males and females less successful in mating than wild-type (Burnet, Connolly, and Dennis, 1971, Anim. Behav. 19: 409-15).
Summary (Interactive Fly)

ubiquitin ligase that functions as an inhibitor of apoptosis - the inhibition of caspase function is counteracted by proapoptotic proteins Hid, Grim and Reaper - niche signaling promotes stem cell survival in the Drosophila testis via the Jak-STAT target DIAP1

Gene Model and Products
Number of Transcripts
6
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Diap1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0075500
2018
438
FBtr0075499
1870
438
FBtr0075501
1820
438
FBtr0333617
1754
438
FBtr0333618
2304
438
FBtr0333619
2233
438
Additional Transcript Data and Comments
Reported size (kB)

2.0 (longest cDNA)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0075255
48.0
438
5.06
FBpp0075254
48.0
438
5.06
FBpp0075256
48.0
438
5.06
FBpp0305793
48.0
438
5.06
FBpp0305794
48.0
438
5.06
FBpp0305795
48.0
438
5.06
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts (via BIR 2 domain) with Dronc (via residues 114-125). Rpr, hid and grim can outcompete Dronc for binding Diap1 therefore removing Diap1-mediated ubiquitination. Interacts (via BIR 2 domain) with HtrA2; this displaces any bound Dronc. Interacts with Strica (PubMed:11550090). The N-terminally cleaved form interacts with Ubr3 (via UBR-type zinc finger) (PubMed:25146930, PubMed:26383956); the interaction promotes the recruitment and uniquitination of substrate capases such as Dronc (PubMed:25146930).

(UniProt, Q24306)
Post Translational Modification

Ubiquitinated and degraded by HtrA2 in apoptotic cells; proteolytic cleavage at specific sites in the BIR domain linker region generating inactive fragments. Mutation of one site reduces but does not abolish cleavage as another site is selected by the protease.

(UniProt, Q24306)
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Diap1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism | ubiquitous

Comment: maternally deposited

anterior endoderm anlage

Comment: anlage in statu nascendi

head mesoderm anlage

Comment: anlage in statu nascendi

posterior ectoderm anlage

Comment: anlage in statu nascendi

trunk mesoderm anlage

Comment: anlage in statu nascendi

ventral ectoderm anlage

Comment: anlage in statu nascendi

Additional Descriptive Data

Expression pattern inferred from unspecified enhancer trap line.

th is expressed throughout the eye imaginal disc and in the embryo in most if not all cells.

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

While larval salivary gland, pupal salivary gland, and pupal Malpighian tubules all show full-length Diap1 transcripts, only the larval salivary gland also shows a band of cleaved Diap1 at 36 kDa.

Immunostaining of wild-type ovarioles with anti-Diap1 revealed that Diap1 expression was high from the germarium until stage 7. It then decreased during stages 7-8, before increasing again at stages 9-11. Expression decreased again at stage 11, and localization of Diap1 shifted from nuclear to cytoplasmic.

Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Diap1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 85 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 43 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Diap1
Transgenic constructs containing regulatory region of Diap1
Deletions and Duplications ( 37 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (13)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
7 of 15
Yes
No
1  
6 of 15
No
No
6 of 15
No
No
4 of 15
No
No
3 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1  
1 of 15
No
Yes
1 of 15
No
No
2  
1 of 15
No
No
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (11)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
7 of 15
Yes
No
7 of 15
Yes
No
7 of 15
Yes
No
4 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (7)
7 of 13
Yes
No
7 of 13
Yes
No
6 of 13
No
No
4 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (10)
6 of 12
Yes
No
6 of 12
Yes
No
5 of 12
No
No
2 of 12
No
No
2 of 12
No
Yes
2 of 12
No
Yes
2 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
Danio rerio (Zebrafish) (8)
7 of 15
Yes
No
4 of 15
No
No
3 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (3)
3 of 15
Yes
No
2 of 15
No
No
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (5)
1 of 9
Yes
No
1 of 9
Yes
No
1 of 9
Yes
No
1 of 9
Yes
Yes
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (1)
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (1)
4 of 12
Yes
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091908Y0 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915084X )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0793 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0747 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0CXH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (4)
5 of 10
1 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 11 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Interacts (via BIR 2 domain) with Dronc (via residues 114-125). Rpr, hid and grim can outcompete Dronc for binding Diap1 therefore removing Diap1-mediated ubiquitination. Interacts (via BIR 2 domain) with HtrA2; this displaces any bound Dronc. Interacts with Strica (PubMed:11550090). The N-terminally cleaved form interacts with Ubr3 (via UBR-type zinc finger) (PubMed:25146930, PubMed:26383956); the interaction promotes the recruitment and uniquitination of substrate capases such as Dronc (PubMed:25146930).
    (UniProt, Q24306 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map

    3-44

    Cytogenetic map
    Sequence location
    3L:16,038,410..16,051,034 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    72C1-72D5
    Left limit from inclusion within Df(3L)st-f13 (FBrf0085566) Right limit from inclusion within Df(3L)brm11 (FBrf0085566)
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    72D-72D
    72D1-72D2
    (determined by in situ hybridisation)
    72B-72B
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Left of (cM)
    Notes
    Stocks and Reagents
    Stocks (259)
    Genomic Clones (29)
    cDNA Clones (86)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of

      Source for identity of: Diap1 th

      Source for database merge of

      Source for merge of: th l(3)S030605b l(3)S106503

      Source for merge of: th l(3)72CDe

      Additional comments

      Changed from 'th' to 'Diap1' to reflect common usage in the literature.

      Other Comments

      The 'l(3)72Dc' (th) complementation group comprises 11 EMS-induced mutant alleles.

      Cleaved th binds to UBR domains and promotes ubiquitination of Ice and Dcp1.

      Gene expression is increased in response to the presence of two copies of Scer\GAL4hs.PB.

      Apoptosis is induced in Kc cells that have been treated with dsRNA made from templates generated with primers directed against this gene.

      S2 cells treated with dsRNA directed against this gene show a dramatic increase in cell death.

      RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

      RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

      th has a role in promoting cell migration in border follicle cells. This effect of th on cell migration is independent of its role in preventing apoptosis, although the effect does result from inhibition of the initiator caspase Nc.

      Loss of function mutations in th result in border follicle cell migration defects.

      th protein is degraded by the "N-end rule" pathway and this process is indispensable for regulating apoptosis. Caspase-mediated cleavage of th protein at position 20 converts the more stable pro-N-degron of th into the highly unstable, Asn-bearing, th N-degron of the N-end rule degradation pathway.

      dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

      RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: cell number is catastrophically reduced.

      th is critical for the induction of apoptosis by rpr and W.

      rpr, W and grim may kill cells by inhibiting th's ability to antagonise caspase function.

      th is necessary to block apoptosis very early in embryonic development. This may reflect a requirement to block maternally provided rpr and W function.

      Domains in addition to the BIR2 domain of the th gene product are required for rpr, grim and W to inactivate th.

      th interacts with the pro-domain of Nc and appears to be a critical regulator of activation of Nc in vivo.

      The function of the th gene is essential for cell survival.

      th is epistatic to the mutant phenotype of Df(3L)H99 (deleted for rpr, W, and grim).

      th promotes cell survival by blocking the activity of the Dcp-1 gene product.

      The product of th can inhibit mammalian cell death induced by overexpression of caspases 1 and 2.

      th mutants exhibit cellularization defects.

      The th protein associates with the tkv receptor in vivo.

      Identification: Enhancer trap screen designed to discover genes involved in the cellular aspects of defense mechanisms, as well as in melanotic tumor formation processes linked to blood cell disregulation.

      Mutations in th are dominant enhancers of rpr induced cell death.

      Identified during a mutagenesis of the 71F-72D region.

      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 83 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      FlyMine - An integrated database for Drosophila genomics
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      PDB - An information portal to biological macromolecular structures
      SignaLink - A signaling pathway resource with multi-layered regulatory networks.
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (65)
      Reported As
      Symbol Synonym
      DIAP1
      (Banreti and Meier, 2020, Hoshika et al., 2020, Mehta et al., 2020, Park et al., 2020, Vissers et al., 2020, Zhuang et al., 2020, Elkholi et al., 2019, Gao et al., 2019, Jagannathan et al., 2019, Raj and Sarkar, 2019, Simoes da Silva et al., 2019, Wu et al., 2019, Bohère et al., 2018, Diwanji and Bergmann, 2018, Feng et al., 2018, Jeong et al., 2018, Khan et al., 2017, Lo Piccolo et al., 2017, Ma et al., 2017, Moon et al., 2017, Nainu et al., 2017, Nakajima and Kuranaga, 2017, Sinenko, 2017, Bhogal et al., 2016, Fallahi et al., 2016, Koerver et al., 2016, Liu et al., 2016, Men et al., 2016, Orme et al., 2016, Pinto-Teixeira et al., 2016, Poon et al., 2016, Qi et al., 2016, Suijkerbuijk et al., 2016, Yadav et al., 2016, Zhang et al., 2016, Arya and White, 2015, Bargiela et al., 2015, Barrios et al., 2015, Denton and Kumar, 2015, Di Cara et al., 2015, Dwivedi et al., 2015, Enomoto et al., 2015, Enzo et al., 2015, Huu et al., 2015, Kovacs et al., 2015, Kwon et al., 2015, Nainu et al., 2015, Reitman et al., 2015, Su, 2015, Tang et al., 2015, Verma et al., 2015, Waldron et al., 2015, Wang et al., 2015, Weng and Cohen, 2015, Zanet et al., 2015, Zhang et al., 2015, Zhang et al., 2015, Fan et al., 2014, Jeibmann et al., 2014, Mulakkal et al., 2014, Panayidou et al., 2014, Robbins et al., 2014, Santhanam et al., 2014, Seo et al., 2014, Shen et al., 2014, Simón et al., 2014, Singh et al., 2014, Yang et al., 2014, Baumgartner et al., 2013, Djiane et al., 2013, Fereres et al., 2013, Forrest et al., 2013, Guo et al., 2013, Hwang et al., 2013, Jenkins et al., 2013, Lee et al., 2013, Liu et al., 2013, Morais da Silva et al., 2013, Park et al., 2013, Rallis et al., 2013, Sidor et al., 2013, Takáts et al., 2013, Tang et al., 2013, Vanden Broeck et al., 2013, Yeh and Bratton, 2013, Yuan and Akey, 2013, Zhang and Cohen, 2013, Zhao et al., 2013, Chountala et al., 2012, Darding and Meier, 2012, Filipiak et al., 2012, Herranz et al., 2012, Kagey et al., 2012, Ma et al., 2012, Nezis, 2012, Pallavi et al., 2012, Pritchett and McCall, 2012, Vandenabeele and Bertrand, 2012, Abdelwahid et al., 2011, Gilbert et al., 2011, Kuranaga, 2011, Lee et al., 2011, Li et al., 2011, Miura, 2011, Muliyil et al., 2011, Otani et al., 2011, Rumpf et al., 2011, Shukla and Tapadia, 2011, Tao and Rolls, 2011, Vandergaast et al., 2011, Arya et al., 2010, Bader et al., 2010, Bakhrat et al., 2010, Bergmann, 2010, Broemer et al., 2010, Cordero and Cagan, 2010, Cully et al., 2010, Hilgers et al., 2010, Kanao et al., 2010, Liu et al., 2010, Malzer et al., 2010, Milton et al., 2010, Neto-Silva et al., 2010, Nezis et al., 2010, Sandu et al., 2010, Yang et al., 2010, Yavari et al., 2010, Bedoukian et al., 2009, Chew et al., 2009, Genevet et al., 2009, González and Busturia, 2009, Grieder et al., 2009, Hamaratoglu et al., 2009, Hong et al., 2009, Kessler and Müller, 2009, Koto et al., 2009, Lee et al., 2009, Mallik and Lakhotia, 2009, Ribaya et al., 2009, Shen et al., 2009, Szuplewski et al., 2009, Zhang et al., 2009, Arya and Lakhotia, 2008, Bardet et al., 2008, Bejarano et al., 2008, Branco et al., 2008, Caldwell et al., 2008, Ditzel et al., 2008, Freel et al., 2008, Griswold et al., 2008, Khan et al., 2008, Li and Cadigan, 2008, Martin et al., 2008, Mehrotra et al., 2008, Sato et al., 2008, Zhao et al., 2008, Abdelwahid et al., 2007, Baum et al., 2007, Caldwell and Eberl, 2007, Challa et al., 2007, Chandraratna et al., 2007, Chan et al., 2007, Chou et al., 2007, Guan et al., 2007, Harvey and Bennett, 2007, Herman-Bachinsky et al., 2007, Igaki et al., 2007, Koto et al., 2007, Kuranaga and Miura, 2007, Lannan et al., 2007, Latouche et al., 2007, Lee et al., 2007, Link et al., 2007, Maier et al., 2007, Mathieu et al., 2007, Pellock et al., 2007, Pfleger et al., 2007, Polesello and Tapon, 2007, Reuveny and Volk, 2007, Ribeiro et al., 2007, Sasaki et al., 2007, Scott et al., 2007, Scott et al., 2007, Song et al., 2007, Sugiyama et al., 2007, Wu et al., 2007, Yi et al., 2007, Yin et al., 2007, Adrain, 2006, Awasaki et al., 2006, Brun et al., 2006, Colombani et al., 2006, Colombani et al., 2006, Hamaratoglu et al., 2006, Hamaratoglu et al., 2006, Hays, 2006, Ho et al., 2006, Janody and Treisman, 2006, Kondo et al., 2006, Kuo et al., 2006, Kuranaga et al., 2006, Leulier et al., 2006, Means et al., 2006, Meyer et al., 2006, Montell, 2006, Müller et al., 2006, Oshima, 2006, Oshima et al., 2006, Thompson and Cohen, 2006, Vidal and Cagan, 2006, Williams et al., 2006, Abdelwahid et al., 2005, Adachi-Yamada et al., 2005, Anderson et al., 2005, Gagic et al., 2005, Gesellchen et al., 2005, Guan et al., 2005, Kanuka et al., 2005, Kornbluth and White, 2005, Lai et al., 2005, Müller et al., 2005, Muro et al., 2005, Tenev et al., 2005, Tomioka et al., 2005, Wech and Nagel, 2005, Wong et al., 2005, Coffman, 2004, Danial and Korsmeyer, 2004, Delanoue et al., 2004, Dotto and Silke, 2004, Geisbrecht and Montell, 2004, Harvey et al., 2004, Hays, 2004, Huh et al., 2004, Huh et al., 2004, Igaki and Miura, 2004, Jia et al., 2004, Kessler and Müller, 2004, Levine, 2004, Otsuki et al., 2004, Ryoo et al., 2004, Shiozaki and Shi, 2004, Udan et al., 2004, Varfolomeev and Ashkenazi, 2004, Wheeler et al., 2004, Xu et al., 2004, Yan et al., 2004, Yeo and Gautier, 2004, Yokokura et al., 2004, Yokokura et al., 2004, Bach et al., 2003, Ditzel et al., 2003, Gagic and Muller, 2003, Giot et al., 2003, Guo et al., 2003, Harvey et al., 2003, Hay and Guo, 2003, Hidalgo and ffrench-Constant, 2003, Hu and Yang, 2003, Ilangovan et al., 2003, Jaklevic and Su, 2003, Jia et al., 2003, Kessler and Muller, 2003, Kuranaga et al., 2003, Meier and Silke, 2003, Moberg and Hariharan, 2003, Morey et al., 2003, Morey et al., 2003, Nijhout, 2003, Olson et al., 2003, Olson et al., 2003, Ou et al., 2003, Pantalacci, 2003, Pantalacci et al., 2003, Rothenberg and Jan, 2003, Schreader et al., 2003, Udan et al., 2003, Varshavsky, 2003, Yokokura et al., 2003, Zachariou et al., 2003, Abrams, 2002, Alonso, 2002, Gozani et al., 2002, Hays et al., 2002, Holcik, 2002, Holley et al., 2002, Huh and Hay, 2002, Igaki et al., 2002, Jackson et al., 2002, Kuranaga et al., 2002, Luque et al., 2002, Martin, 2002, Moreno et al., 2002, Palaga and Osborne, 2002, Ryoo et al., 2002, Srinivasula et al., 2002, Srinivasula et al., 2002, Tapon et al., 2002, Tenev et al., 2002, Wilson et al., 2002, Wing et al., 2002, Wright and Clem, 2002, Yoo et al., 2002, Yu et al., 2002, Zimmermann et al., 2002, Bangs et al., 2001, Doumanis et al., 2001, Hirose et al., 2001, Silke and Vaux, 2001, Wu et al., 2001, Hawkins et al., 2000, Jones et al., 2000, Lisi et al., 2000, Meier et al., 2000, Meier et al., 2000, Reed and Bischoff, 2000, Steller, 2000, Takatsu et al., 2000, Vernooy et al., 2000, Vernooy et al., 2000, Vernooy et al., 2000, Abrams, 1999, Hawkins et al., 1999, Song and Steller, 1999, Song and Steller, 1999, Song and Steller, 1999, Vaux and Korsmeyer, 1999, Wang et al., 1999, Ye and Fortini, 1999, Bergmann et al., 1998, Foley and Cooley, 1998, LaCasse et al., 1998, Oeda et al., 1998, Wing and Nambu, 1998, Clem and Duckett, 1997, Harvey et al., 1997, McCall and Steller, 1997, Chinnaiyan and Dixit, 1996, Hay, 1996.1.5, Hay et al., 1995)
      Diap-1/Th
      Diap1
      (Jevitt et al., 2020, Jung et al., 2020, Perez-Gomez et al., 2020, Singh et al., 2020, Sun et al., 2020, Wang and Spradling, 2020, Domingos et al., 2019, Herrera and Bach, 2019, Khan et al., 2019, Kockel et al., 2019, Liu et al., 2019, Meltzer et al., 2019, Merkling et al., 2019, Moreno et al., 2019, Nan et al., 2019, Nelson et al., 2019, Singh et al., 2019, Skouloudaki et al., 2019, Tanaka et al., 2019, Tsogtbaatar et al., 2019, Xu et al., 2019, Yee et al., 2019, Ahmed-de-Prado and Baonza, 2018, Azuma et al., 2018, Baena-Lopez et al., 2018, Campbell et al., 2018, Cong et al., 2018, Richardson and Portela, 2018, Xu et al., 2018, Aw et al., 2017, Garcia-Garcia et al., 2017, Li et al., 2017, Schott et al., 2017, Shu and Deng, 2017, Tavignot et al., 2017, Torres et al., 2017, Transgenic RNAi Project members, 2017-, Chan et al., 2016, Dabrowska et al., 2016, Deng et al., 2016, Diaz-Garcia et al., 2016, Eroglu and Derry, 2016, Huang et al., 2016, Hwangbo et al., 2016, Jenny and Basler, 2016, Kockel et al., 2016, Kuleesha et al., 2016, Lee et al., 2016, Lee et al., 2016, Nakazawa et al., 2016, Bae et al., 2015, Cao et al., 2015, Kolahgar et al., 2015, Li et al., 2015, Martínez-Morentin et al., 2015, Means et al., 2015, Nicolson et al., 2015, Sakamaki et al., 2015, Wang and Baker, 2015, Zhang et al., 2015, Zheng et al., 2015, Zimmermann et al., 2015, Bhaskar et al., 2014, Ferguson and Martinez-Agosto, 2014, Huang et al., 2014, Netter, 2014.2.26, Rauskolb et al., 2014, Steller et al., 2014.7.9, Baumgartner et al., 2013, Das and Cagan, 2013, Das et al., 2013, Das et al., 2013, Degoutin et al., 2013, Denton et al., 2013, Dick and Megeney, 2013, Hirabayashi et al., 2013, Huang et al., 2013, Jin et al., 2013, Koontz et al., 2013, Levayer and Moreno, 2013, Liu et al., 2013, Oh et al., 2013, Rallis et al., 2013, Yacobi-Sharon et al., 2013, Yin et al., 2013, Yu et al., 2013, Etchegaray et al., 2012, Fabian and Brill, 2012, Florentin and Arama, 2012, Foronda et al., 2012, Hafezi et al., 2012, Lee et al., 2012, Lim et al., 2012, Miura, 2012, Pushpavalli et al., 2012, Chan et al., 2011, Miles et al., 2011, Morata et al., 2011, Rauskolb et al., 2011, Reddy and Irvine, 2011, Suissa et al., 2011, Winbush and Weeks, 2011, Zhang et al., 2011, Baumgartner et al., 2010, Bejarano et al., 2010, Reddy et al., 2010, Mao et al., 2009, Oh and Irvine, 2009, Oh et al., 2009, Reuveny et al., 2009, Romani et al., 2009, Wang and Kalderon, 2009, Xu et al., 2009, Joza et al., 2008, Lee et al., 2008, Pret et al., 2008, Protzer et al., 2008, Rogulja et al., 2008, Shapiro and Ryoo, 2008, Vicente-Crespo et al., 2008, Arama et al., 2007, Dong et al., 2007, Lee et al., 2007, Tenev et al., 2007, Vicente et al., 2007, Volk and Reuveny, 2007, Baehrecke, 2006, Bergmann, 2006, Cho et al., 2006, Herz, 2006, Herz et al., 2006, Silva, 2006, Silva et al., 2006, Wells et al., 2006, Yoo, 2005, Hsu et al., 2004, Kumar and Cakouros, 2004, Baehrecke, 2003, Claveria and Torres, 2003, Jassim et al., 2003, Kramer et al., 2003, Rodriguez et al., 2002, Harvey et al., 2001, Chen and Abrams, 2000, Kumar, 2000, Uren et al., 1998)
      E(rpr)3-1
      diap1
      (Bajpai et al., 2020, Blanco et al., 2020, Yeom et al., 2020, Binh et al., 2019, Guo et al., 2019, Kim et al., 2019, Lee et al., 2019, Ma et al., 2019, Pinal et al., 2019, Sun et al., 2019, Cho et al., 2018, Katsukawa et al., 2018, Moon et al., 2018, Kamber Kaya et al., 2017, Lu et al., 2017, Martín et al., 2017, Napoletano et al., 2017, Smart et al., 2017, Wang et al., 2017, Zhang et al., 2017, Barron and Moberg, 2016, Chung et al., 2016, Willsey et al., 2016, Dong et al., 2015, Levayer et al., 2015, Means et al., 2015, Parker and Struhl, 2015, Xing et al., 2015, Zhang et al., 2015, Dodson et al., 2014, Huang and Kalderon, 2014, Ihry and Bashirullah, 2014, Ikmi et al., 2014, Qing et al., 2014, Andersen et al., 2013, Enderle and McNeill, 2013, Geisbrecht et al., 2013, Herrera et al., 2013, Hirabayashi et al., 2013, Huang et al., 2013, Kanda et al., 2013, Koontz et al., 2013, Lee et al., 2013, Liu et al., 2013, Oh et al., 2013, Perea et al., 2013, Schertel et al., 2013, Yacobi-Sharon et al., 2013, Etchegaray et al., 2012, Fausti et al., 2012, Herranz et al., 2012, Ihry et al., 2012, Liu et al., 2012, Marchal et al., 2012, Marinari et al., 2012, Meier et al., 2012, Poernbacher et al., 2012, Verghese et al., 2012, Yue et al., 2012, Fernández et al., 2011, Gafuik and Steller, 2011, Genevet and Tapon, 2011, Khammari et al., 2011, Laprise, 2011, Lee et al., 2011, Richter et al., 2011, Sun et al., 2011, Yan et al., 2011, Zhao et al., 2011, Baumgartner et al., 2010, Benitez et al., 2010, Chen et al., 2010, Das Thakur et al., 2010, Genevet et al., 2010, Grzeschik et al., 2010, Ling et al., 2010, Matova and Anderson, 2010, Menéndez et al., 2010, Nicolay et al., 2010, Robinson et al., 2010, Sekyrova et al., 2010, Shaw et al., 2010, Wang et al., 2010, Yu et al., 2010, Chittaranjan et al., 2009, Creagh et al., 2009, Doumanis et al., 2009, Kondo et al., 2009, Martín et al., 2009, Ohayon et al., 2009, Umemori et al., 2009, Betz et al., 2008, Dorstyn and Kumar, 2008, Dutta and Baehrecke, 2008, Ganguly et al., 2008, Settles and Friesen, 2008, Shapiro et al., 2008, Shimizu et al., 2008, Wang et al., 2008, Willecke et al., 2008, Wu et al., 2008, Yu et al., 2008, Zhang et al., 2008, Zhang et al., 2008, Betz et al., 2007, Copeland et al., 2007, Gregory et al., 2007, Hamaratoglu et al., 2007, Huh et al., 2007, Peterson et al., 2007, Primrose et al., 2007, Ribeiro et al., 2007, Tanaka-Matakatsu et al., 2007, Yin et al., 2007, Yoneda et al., 2007, Bashirullah et al., 2006, Choi et al., 2006, Leulier et al., 2006, Montell, 2006, Nolo et al., 2006, Singh et al., 2006, Vidal et al., 2006, Xu et al., 2006, Xu et al., 2006, Huang et al., 2005, Xu et al., 2005, Xu et al., 2005, Hay et al., 2004, Muro et al., 2004, Ryoo et al., 2004, Yin and Thummel, 2004, Yin et al., 2004, Bergmann et al., 2003, Ryoo and Steller, 2003, Yin and Thummel, 2003, Ditzel and Meier, 2002, Gorski and Marra, 2002, Igaki et al., 2002, Muro et al., 2002, Ryoo et al., 2002, Wing et al., 2001, Bialik and Gottlieb, 2000, Buszczak and Segraves, 2000, Colussi et al., 2000, Goyal et al., 2000, Hsu and Schulz, 2000, Kumar and Doumanis, 2000, Pecasse et al., 2000, Quinn et al., 2000, Tittel and Steller, 2000, Agapite et al., 1999, Kanuka et al., 1999, White et al., 1999, Bergmann et al., 1998, Sawamoto et al., 1998, Jiang et al., 1997)
      l(3)S030605
      l(3)S106503
      th
      (McSharry and Beitel, 2019, Shinoda et al., 2019, Mondal et al., 2018, Stephano et al., 2018, Wang et al., 2018, Chan et al., 2017, Ruppert et al., 2017, Mao et al., 2016, Bunker et al., 2015, Doggett et al., 2015, Kwon et al., 2015, Merkling et al., 2015, Zhang et al., 2015, Faisal et al., 2014, Merlo et al., 2014, Robbins et al., 2014, Bonke et al., 2013, Degoutin et al., 2013, Djiane et al., 2013, Hirabayashi et al., 2013, Lee et al., 2013, Lindsley et al., 2013, Lu et al., 2013, Ryoo, 2013.7.26, Schertel et al., 2013, Chakrabarti et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Kang et al., 2012, Zhai et al., 2012, Cooper and Kennison, 2011, Du et al., 2011, Gilbert et al., 2011, Johnson et al., 2011, Khammari et al., 2011, Rauskolb et al., 2011, Reddy and Irvine, 2011, Rumpf et al., 2011, Winbush and Weeks, 2011, Arya et al., 2010, Kim et al., 2010, Matova and Anderson, 2010, Milton et al., 2010, Sakurai et al., 2010, Chew et al., 2009, Kessler and Müller, 2009, Kondo et al., 2009, Koto et al., 2009, Ohayon et al., 2009, Ribaya et al., 2009, Branco et al., 2008, Chen et al., 2008, Garcia-Lopez et al., 2008, Hou et al., 2008, Oh and Irvine, 2008, Vicente-Crespo et al., 2008, Wang et al., 2008, Zhang et al., 2008, Chandraratna et al., 2007, Derré et al., 2007, Guan et al., 2007, Lai et al., 2007, Latouche et al., 2007, Link et al., 2007, Mislak et al., 2007, Pfleger et al., 2007, Quinones-Coello, 2007, Tanaka-Matakatsu et al., 2007, Balakireva et al., 2006, Cho et al., 2006, Janody and Treisman, 2006, Kuo et al., 2006, Morris et al., 2006, Muro et al., 2006, Laviolette et al., 2005, Terashima and Bownes, 2005, Wech and Nagel, 2005, Delanoue et al., 2004, Ghosh and Feany, 2004, Moskalev and Zainullin, 2004, Renault et al., 2004, Takahashi and Ting, 2004)
      Name Synonyms
      Death-associated inhibitor of apoptosis 1
      Drosophila Inhibitor of Apoptosis
      Drosophila Inhibitor of Apoptosis 1
      Drosophila Inhibitor of Apoptosis Protein
      Drosophila Inhibitor of Apoptosis Protein 1
      Drosophila Inhibitor of Apoptosis Protein-1
      Drosophila Inhibitor of apoptosis protein 1
      Drosophila inhibitor of apoptosis protein
      Drosophila inhibitor-of-apoptosis protein 1
      Drosophila thread/inhibitor of apoptosis protein-1
      Inhibitor of Apoptosis Protein 1
      Inhibitor of apoptosis 1
      Inhibitors of Apoptosis protein
      degradation of inhibitors of apoptosis
      drosophila inhibitor of apoptosis protein
      inhibitor of apoptosis
      inhibitor of apoptosis protein 1
      inhibitor of apoptosis-1
      inhibitor of apoptotic protein 1
      lethal (3) 72CDe
      Secondary FlyBase IDs
      • FBgn0016903
      • FBgn0003691
      • FBgn0011383
      • FBgn0015246
      • FBgn0046835
      • FBgn0046836
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (992)