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Gene Dmel\th

General Information
Symbol	Dmel\th	Species	D. melanogaster
Name	thread	Annotation symbol	CG12284
Feature type	protein_coding_gene	FlyBase ID	FBgn0260635
Gene Model Status	Current	Stock availability	265 publicly available
Also Known As	DIAP1, DIAP-1, Diap, D-IAP1, IAP1, IAP, l(3)72CDe
Genomic Location
Chromosome (arm)	3L	Recombination map	3-43.2
Cytogenetic map	72C1-72D1	Sequence location	3L:16,031,505..16,043,755 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene thread is referred to in FlyBase by the symbol Dmel\th (CG12284, FBgn0260635). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: enzyme binding; protein binding; NEDD8 ligase activity. There is experimental evidence for 13 unique biological process terms, many of which group under: biological regulation; sensory organ development; system development; programmed cell death; regulation of apoptosis; cellular process; cell death; cellular component organization or biogenesis; multicellular organismal development; localization; post-embryonic organ morphogenesis. 175 alleles are reported. The phenotypes of these alleles are annotated with: organ system; multicellular structure; organ system subdivision; portion of tissue; external compound sense organ; adult segment; imaginal precursor; non-connected developing system; cell part; cytoplasmic part; embryonic procephalic segment; anatomical structure; embryonic mandibular segment; synapse. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Baculoviral inhibition of apoptosis protein repeat; Zinc finger, RING-type; Zinc finger, RING/FYVE/PHD-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 06-24 hour embryonic stages, during late larval stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult ovary, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1636787_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of th. Gene sequence location is 3L:16031505..16043755.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	th: thread Aristae threadlike, without side branches. Mutation affects development of tarsal claws at 29 (Mglinetz and Ivanov, 1975). Deficiency for th homozygous lethal (Ward and Alexander, 1957; Korge, 1972). Mutant males and females less successful in mating than wild-type (Burnet, Connolly, and Dennis, 1971, Anim. Behav. 19: 409-15).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Li et al., 2011, Nat. Commun. 2: 408 Slack et al., 2006, BMC Genet. 7: 33 Yang et al., 2010, EMBO J. 29(18): 3196--3207 Gilbert et al., 2011, Dev. Cell 20(5): 700--712 Sequence features HFA11404 BKN24114
FB2011_10	References Lee et al., 2011, PLoS Genet. 7(9): e1002261 Richter et al., 2011, Nat. Cell Biol. 13(9): 1029--1039 Ying et al., 2011, PLoS ONE 6(9): e23863
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 72C1-72D1   Left limit from inclusion within Df(3L)st-f13 (FBrf0085566) Right limit from inclusion within Df(3L)brm11 (FBrf0085566); Limits computationally determined from genome sequence between P{EP}Tfb2EP572 and P{lacW}thj5C8&P{PZ}Mbs03802
Experimentally Determined Cytological Location
Cytogenetic map Notes References 72D-72D     (Hay, 1996.1.5) 72D1-72D2   (determined by in situ hybridisation)   (Spradling et al., 1999) 72B-72B   (determined by in situ hybridisation)   (Szeged Stock Center, 1998-) 72B-72B   (determined by in situ hybridisation)   (Deak et al., 1997) 72D1-72D2   (determined by in situ hybridisation)   (Hay et al., 1997) 72D1-72D2     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	3- (Hay, 1996.1.5) 3-43.2 (Bishop and Sherald, 1981)
Left of (cM)	Pgm (Hjorth, 1970)
Right of (cM)	Idh (Bentley et al., 1983) Rst(3)amd (Bishop and Sherald, 1981)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\th for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) th-RA FBtr0075500  NM_079377   2014   438 th-RB FBtr0075499  NM_168644   1859   438 th-RC FBtr0075501  NM_168645   1820   438
Additional Transcript Data & Comments
Reported size (kB)	2.0 (longest cDNA) (Hay et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein th-PA   FBpp0075255   48.0   438   5.06     NP_524101   AAF49548 th-PB   FBpp0075254   48.0   438   5.06     NP_730097   AAG22319 th-PC   FBpp0075256   48.0   438   5.06     NP_730098   AAN11757
Additional Polypeptide Data & Comments
Reported size (kDa)	438 (aa) (Hay et al., 1995)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Baculoviral inhibition of apoptosis protein repeat (IPR001370) Zinc finger, RING-type (IPR001841) Zinc finger, RING/FYVE/PHD-type (IPR013083) PDB - Protein Data Bank. An information portal to biological macromolecular structures • 1JD4 1JD5 1JD6
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA801628   AA803381   AE014296 AAF49548   AE014296 AAG22319   AE014296 AAN11757   AI063332   AI109918   AI257435   AI258503   AI259474   AI259937   AI292436   AI294506   AI387189   AI402377   AI405850   AI405960   AI531081   AI533882   AI534353   AI534677   AI541903   AI543065   AQ034091   AQ073145   AQ073878   AQ074017   AQ254653   AW940586   AY119524 AAM50178   AZ300907   BE978623   BF487815   BF495621   BF499536   BI162867   BI165506   BI169774   BI170366   BI356379   BI607081   BI635443   BI635637   BI635779   BI638683   BT031197   BZ748784   CA803472   CA804844   CA805412   CA806491   CA806684   CL705817   CO177809   CO179376   CO179387   CO189657   CO264459   CO265978   CO266483   CO273326   CO276194   CO280961   CO282446   CO292827   CO293611   CO298550   CO300985   CO302869   CO305971   CO314340   CO314412   CO320830   CO335643   CO340041   CO340334   CZ470495   CZ470824   CZ471363   CZ475620   CZ477599   CZ477846   CZ480521   CZ481316   CZ484213   EC058398   EC059997   EC063792   EC067271   EC073560   EC076692   EC081258   EC083871   EC198012   EC199452   EC200503   EC203518   EC209545   EC210312   EC222298   EC222923   EC224152   EC231742   EC231806   EC232983   EC241271   EC251842   EC259230   EL880252   EL880253   EL880346   EL880347   EL880439   ES690323   ES690562   ES692281   ES692292   ES692505   ES692842   GH739857   GH740374   GH741205   GH742342   GH744500   GH744945   GH765602   GH766017   GH767028   GH767467   GH768763   GH779558   L49440 AAC41609
UniProtKB/Swiss-Prot	Q24306
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous   (Hay et al., 1995) larval stage   eye-antennal disc   (Hay et al., 1995)
Additional Descriptive Data
	th is expressed throughout the eye imaginal disc and in the embryo in most if not all cells. (Hay et al., 1995)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11   organism | ubiquitous   (Ryoo et al., 2002) late third instar larval stage   wing disc | ubiquitous   (Ryoo et al., 2002) Comment:Expression strongest at D/V boundary wing disc | dorsal/ventral compartment boundary   (Ryoo et al., 2002) oogenesis stage S9 -- S10   oocyte | ubiquitous   (Geisbrecht and Montell, 2004) western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism   (Ryoo et al., 2002)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0260635    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0260635 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 06-24 hour embryonic stages, during late larval stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0260635 expression level Developmental Stage   Expression Level embryo 00-02hr    2068 embryo 02-04hr    3719 embryo 04-06hr    9783 embryo 06-08hr    20474 embryo 08-10hr    17511 embryo 10-12hr    21784 embryo 12-14hr    12879 embryo 14-16hr    11418 embryo 16-18hr    9996 embryo 18-20hr    10992 embryo 20-22hr    9923 embryo 22-24hr    8986 larva L1    4557 larva L2    2881 larva L3 12hr old    2586 larva L3 puffstage 1-2    4317 larva L3 puffstage 3-6    7410 larva L3 puffstage 7-9    10658 white prepupae new    12631 white prepupae 12hr    13215 white prepupae 24hr    12688 pupae 2d postWPP    13030 pupae 3d postWPP    4847 pupae 4d postWPP    5519 adult male 01day    4853 adult male 05day    6475 adult male 30day    6935 adult female 01day    4292 adult female 05day    3259 adult female 30day    3485 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2068) embryo 02-04hr  (3719) embryo 04-06hr  (9783) embryo 06-08hr  (20474) embryo 08-10hr  (17511) embryo 10-12hr  (21784) embryo 12-14hr  (12879) embryo 14-16hr  (11418) embryo 16-18hr  (9996) embryo 18-20hr  (10992) embryo 20-22hr  (9923) embryo 22-24hr  (8986) larva L1  (4557) larva L2  (2881) larva L3 12hr old  (2586) larva L3 puffstage 1-2  (4317) larva L3 puffstage 3-6  (7410) larva L3 puffstage 7-9  (10658) white prepupae new  (12631) white prepupae 12hr  (13215) white prepupae 24hr  (12688) pupae 2d postWPP  (13030) pupae 3d postWPP  (4847) pupae 4d postWPP  (5519) adult male 01day  (4853) adult male 05day  (6475) adult male 30day  (6935) adult female 01day  (4292) adult female 05day  (3259) adult female 30day  (3485) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2068) embryo 02-04hr  (3719) embryo 04-06hr  (9783) embryo 06-08hr  (20474) embryo 08-10hr  (17511) embryo 10-12hr  (21784) embryo 12-14hr  (12879) embryo 14-16hr  (11418) embryo 16-18hr  (9996) embryo 18-20hr  (10992) embryo 20-22hr  (9923) embryo 22-24hr  (8986) larva L1  (4557) larva L2  (2881) larva L3 12hr old  (2586) larva L3 puffstage 1-2  (4317) larva L3 puffstage 3-6  (7410) larva L3 puffstage 7-9  (10658) white prepupae new  (12631) white prepupae 12hr  (13215) white prepupae 24hr  (12688) pupae 2d postWPP  (13030) pupae 3d postWPP  (4847) pupae 4d postWPP  (5519) adult male 01day  (4853) adult male 05day  (6475) adult male 30day  (6935) adult female 01day  (4292) adult female 05day  (3259) adult female 30day  (3485) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2068 embryo 02-04hr    3719 embryo 04-06hr    9783 embryo 06-08hr  (20474) embryo 08-10hr  (17511) embryo 10-12hr  (21784) embryo 12-14hr  (12879) embryo 14-16hr  (11418) embryo 16-18hr    9996 embryo 18-20hr  (10992) embryo 20-22hr    9923 embryo 22-24hr    8986 larva L1    4557 larva L2    2881 larva L3 12hr old    2586 larva L3 puffstage 1-2    4317 larva L3 puffstage 3-6    7410 larva L3 puffstage 7-9  10658 white prepupae new  (12631) white prepupae 12hr  (13215) white prepupae 24hr  (12688) pupae 2d postWPP  (13030) pupae 3d postWPP    4847 pupae 4d postWPP    5519 adult male 01day    4853 adult male 05day    6475 adult male 30day    6935 adult female 01day    4292 adult female 05day    3259 adult female 30day    3485 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2068 embryo 02-04hr    3719 embryo 04-06hr    9783 embryo 06-08hr    20474 embryo 08-10hr    17511 embryo 10-12hr    21784 embryo 12-14hr    12879 embryo 14-16hr    11418 embryo 16-18hr    9996 embryo 18-20hr    10992 embryo 20-22hr    9923 embryo 22-24hr    8986 larva L1    4557 larva L2    2881 larva L3 12hr old    2586 larva L3 puffstage 1-2    4317 larva L3 puffstage 3-6    7410 larva L3 puffstage 7-9    10658 white prepupae new    12631 white prepupae 12hr    13215 white prepupae 24hr    12688 pupae 2d postWPP    13030 pupae 3d postWPP    4847 pupae 4d postWPP    5519 adult male 01day    4853 adult male 05day    6475 adult male 30day    6935 adult female 01day    4292 adult female 05day    3259 adult female 30day    3485 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0260635 expression level Developmental Stage   Expression Level embryo 00-02hr    2068 embryo 02-04hr    3719 embryo 04-06hr    9783 embryo 06-08hr    20474 embryo 08-10hr    17511 embryo 10-12hr    21784 embryo 12-14hr    12879 embryo 14-16hr    11418 embryo 16-18hr    9996 embryo 18-20hr    10992 embryo 20-22hr    9923 embryo 22-24hr    8986 larva L1    4557 larva L2    2881 larva L3 12hr old    2586 larva L3 puffstage 1-2    4317 larva L3 puffstage 3-6    7410 larva L3 puffstage 7-9    10658 white prepupae new    12631 white prepupae 12hr    13215 white prepupae 24hr    12688 pupae 2d postWPP    13030 pupae 3d postWPP    4847 pupae 4d postWPP    5519 adult male 01day    4853 adult male 05day    6475 adult male 30day    6935 adult female 01day    4292 adult female 05day    3259 adult female 30day    3485 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2068) embryo 02-04hr  (3719) embryo 04-06hr  (9783) embryo 06-08hr  (20474) embryo 08-10hr  (17511) embryo 10-12hr  (21784) embryo 12-14hr  (12879) embryo 14-16hr  (11418) embryo 16-18hr  (9996) embryo 18-20hr  (10992) embryo 20-22hr  (9923) embryo 22-24hr  (8986) larva L1  (4557) larva L2  (2881) larva L3 12hr old  (2586) larva L3 puffstage 1-2  (4317) larva L3 puffstage 3-6  (7410) larva L3 puffstage 7-9  (10658) white prepupae new  (12631) white prepupae 12hr  (13215) white prepupae 24hr  (12688) pupae 2d postWPP  (13030) pupae 3d postWPP  (4847) pupae 4d postWPP  (5519) adult male 01day  (4853) adult male 05day  (6475) adult male 30day  (6935) adult female 01day  (4292) adult female 05day  (3259) adult female 30day  (3485) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  2068 embryo 02-04hr  (3719) embryo 04-06hr  (9783) embryo 06-08hr  (20474) embryo 08-10hr  (17511) embryo 10-12hr  (21784) embryo 12-14hr  (12879) embryo 14-16hr  (11418) embryo 16-18hr  (9996) embryo 18-20hr  (10992) embryo 20-22hr  (9923) embryo 22-24hr  (8986) larva L1  (4557) larva L2  (2881) larva L3 12hr old  (2586) larva L3 puffstage 1-2  (4317) larva L3 puffstage 3-6  (7410) larva L3 puffstage 7-9  (10658) white prepupae new  (12631) white prepupae 12hr  (13215) white prepupae 24hr  (12688) pupae 2d postWPP  (13030) pupae 3d postWPP  (4847) pupae 4d postWPP  (5519) adult male 01day  (4853) adult male 05day  (6475) adult male 30day  (6935) adult female 01day  (4292) adult female 05day  (3259) adult female 30day  (3485) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2068 embryo 02-04hr    3719 embryo 04-06hr    9783 embryo 06-08hr  20474 embryo 08-10hr  17511 embryo 10-12hr  (21784) embryo 12-14hr  12879 embryo 14-16hr  11418 embryo 16-18hr    9996 embryo 18-20hr  10992 embryo 20-22hr    9923 embryo 22-24hr    8986 larva L1    4557 larva L2    2881 larva L3 12hr old    2586 larva L3 puffstage 1-2    4317 larva L3 puffstage 3-6    7410 larva L3 puffstage 7-9  10658 white prepupae new  12631 white prepupae 12hr  13215 white prepupae 24hr  12688 pupae 2d postWPP  13030 pupae 3d postWPP    4847 pupae 4d postWPP    5519 adult male 01day    4853 adult male 05day    6475 adult male 30day    6935 adult female 01day    4292 adult female 05day    3259 adult female 30day    3485 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2068 embryo 02-04hr    3719 embryo 04-06hr    9783 embryo 06-08hr    20474 embryo 08-10hr    17511 embryo 10-12hr    21784 embryo 12-14hr    12879 embryo 14-16hr    11418 embryo 16-18hr    9996 embryo 18-20hr    10992 embryo 20-22hr    9923 embryo 22-24hr    8986 larva L1    4557 larva L2    2881 larva L3 12hr old    2586 larva L3 puffstage 1-2    4317 larva L3 puffstage 3-6    7410 larva L3 puffstage 7-9    10658 white prepupae new    12631 white prepupae 12hr    13215 white prepupae 24hr    12688 pupae 2d postWPP    13030 pupae 3d postWPP    4847 pupae 4d postWPP    5519 adult male 01day    4853 adult male 05day    6475 adult male 30day    6935 adult female 01day    4292 adult female 05day    3259 adult female 30day    3485 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0260635    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0260635 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult ovary, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0260635 expression level Tissue   Expression Level Larval Central Nervous System    926.075 Larval Midgut    1576.4 Larval Hindgut    552.3 Larval Malpighian Tubules    1084.9 Larval Fat Body    687.8 Larval Salivary Gland    1033.3 Larval Trachea    541.625 Larval Carcass    621.825 Adult Head    647.2 Adult Eye    432.45 Adult Brain    803.5 Adult Thoracic-Abdominal Ganglion    786 Adult Crop    1381 Adult Midgut    803.1 Adult Hindgut    831.1 Adult Malpighian Tubules    1023.2 Adult Fat Body    813.7 Adult Salivary Gland    935.1 Adult Heart    805.45 Adult VirginFemale Spermatheca    1051.2 Adult InseminatedFemale Spermatheca    1114.2 Adult Ovary    259.6 Adult Testis    381 Adult Male Accessory Gland    685.4 Adult Carcass    969.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (926.075) Larval Midgut  (1576.4) Larval Hindgut  (552.3) Larval Malpighian Tubules  (1084.9) Larval Fat Body  (687.8) Larval Salivary Gland  (1033.3) Larval Trachea  (541.625) Larval Carcass  (621.825) Adult Head  (647.2) Adult Eye    432.45 Adult Brain  (803.5) Adult Thoracic-Abdominal Ganglion  (786) Adult Crop  (1381) Adult Midgut  (803.1) Adult Hindgut  (831.1) Adult Malpighian Tubules  (1023.2) Adult Fat Body  (813.7) Adult Salivary Gland  (935.1) Adult Heart  (805.45) Adult VirginFemale Spermatheca  (1051.2) Adult InseminatedFemale Spermatheca  (1114.2) Adult Ovary    259.6 Adult Testis    381 Adult Male Accessory Gland  (685.4) Adult Carcass  (969.3) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    926.075 Larval Midgut  (1576.4) Larval Hindgut    552.3 Larval Malpighian Tubules  (1084.9) Larval Fat Body    687.8 Larval Salivary Gland  1033.3 Larval Trachea    541.625 Larval Carcass    621.825 Adult Head    647.2 Adult Eye    432.45 Adult Brain    803.5 Adult Thoracic-Abdominal Ganglion    786 Adult Crop  (1381) Adult Midgut    803.1 Adult Hindgut    831.1 Adult Malpighian Tubules  1023.2 Adult Fat Body    813.7 Adult Salivary Gland    935.1 Adult Heart    805.45 Adult VirginFemale Spermatheca  1051.2 Adult InseminatedFemale Spermatheca  (1114.2) Adult Ovary    259.6 Adult Testis    381 Adult Male Accessory Gland    685.4 Adult Carcass    969.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    926.075 Larval Midgut    1576.4 Larval Hindgut    552.3 Larval Malpighian Tubules    1084.9 Larval Fat Body    687.8 Larval Salivary Gland    1033.3 Larval Trachea    541.625 Larval Carcass    621.825 Adult Head    647.2 Adult Eye    432.45 Adult Brain    803.5 Adult Thoracic-Abdominal Ganglion    786 Adult Crop    1381 Adult Midgut    803.1 Adult Hindgut    831.1 Adult Malpighian Tubules    1023.2 Adult Fat Body    813.7 Adult Salivary Gland    935.1 Adult Heart    805.45 Adult VirginFemale Spermatheca    1051.2 Adult InseminatedFemale Spermatheca    1114.2 Adult Ovary    259.6 Adult Testis    381 Adult Male Accessory Gland    685.4 Adult Carcass    969.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0260635 expression level Tissue   Expression Level Larval Central Nervous System    926.075 Larval Midgut    1576.4 Larval Hindgut    552.3 Larval Malpighian Tubules    1084.9 Larval Fat Body    687.8 Larval Salivary Gland    1033.3 Larval Trachea    541.625 Larval Carcass    621.825 Adult Head    647.2 Adult Eye    432.45 Adult Brain    803.5 Adult Thoracic-Abdominal Ganglion    786 Adult Crop    1381 Adult Midgut    803.1 Adult Hindgut    831.1 Adult Malpighian Tubules    1023.2 Adult Fat Body    813.7 Adult Salivary Gland    935.1 Adult Heart    805.45 Adult VirginFemale Spermatheca    1051.2 Adult InseminatedFemale Spermatheca    1114.2 Adult Ovary    259.6 Adult Testis    381 Adult Male Accessory Gland    685.4 Adult Carcass    969.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (926.075) Larval Midgut  (1576.4) Larval Hindgut  552.3 Larval Malpighian Tubules  (1084.9) Larval Fat Body  687.8 Larval Salivary Gland  (1033.3) Larval Trachea  541.625 Larval Carcass  621.825 Adult Head  647.2 Adult Eye    432.45 Adult Brain  803.5 Adult Thoracic-Abdominal Ganglion  786 Adult Crop  (1381) Adult Midgut  803.1 Adult Hindgut  (831.1) Adult Malpighian Tubules  (1023.2) Adult Fat Body  813.7 Adult Salivary Gland  (935.1) Adult Heart  805.45 Adult VirginFemale Spermatheca  (1051.2) Adult InseminatedFemale Spermatheca  (1114.2) Adult Ovary    259.6 Adult Testis    381 Adult Male Accessory Gland  685.4 Adult Carcass  (969.3) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    926.075 Larval Midgut  1576.4 Larval Hindgut    552.3 Larval Malpighian Tubules  1084.9 Larval Fat Body    687.8 Larval Salivary Gland  1033.3 Larval Trachea    541.625 Larval Carcass    621.825 Adult Head    647.2 Adult Eye    432.45 Adult Brain    803.5 Adult Thoracic-Abdominal Ganglion    786 Adult Crop  1381 Adult Midgut    803.1 Adult Hindgut    831.1 Adult Malpighian Tubules  1023.2 Adult Fat Body    813.7 Adult Salivary Gland    935.1 Adult Heart    805.45 Adult VirginFemale Spermatheca  1051.2 Adult InseminatedFemale Spermatheca  1114.2 Adult Ovary    259.6 Adult Testis    381 Adult Male Accessory Gland    685.4 Adult Carcass    969.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    926.075 Larval Midgut    1576.4 Larval Hindgut    552.3 Larval Malpighian Tubules    1084.9 Larval Fat Body    687.8 Larval Salivary Gland    1033.3 Larval Trachea    541.625 Larval Carcass    621.825 Adult Head    647.2 Adult Eye    432.45 Adult Brain    803.5 Adult Thoracic-Abdominal Ganglion    786 Adult Crop    1381 Adult Midgut    803.1 Adult Hindgut    831.1 Adult Malpighian Tubules    1023.2 Adult Fat Body    813.7 Adult Salivary Gland    935.1 Adult Heart    805.45 Adult VirginFemale Spermatheca    1051.2 Adult InseminatedFemale Spermatheca    1114.2 Adult Ovary    259.6 Adult Testis    381 Adult Male Accessory Gland    685.4 Adult Carcass    969.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    647.2   NA  Eye    432.45   NA  Brain    803.5   926.075  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    786   NA  Crop    1381   1576.4  Midgut    803.1   552.3  Hindgut    831.1   1084.9  Malpighian Tubules    1023.2   687.8  Fat Body    813.7   1033.3  Salivary Gland    935.1   NA  Heart    805.45   541.625  Trachea    NA   NA  VirginFemale Spermatheca    1051.2   NA  InseminatedFemale Spermatheca    1114.2   NA  Ovary    259.6   NA  Testis    381   NA  Male Accessory Gland    685.4   621.825  Carcass    969.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_11
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0260635
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 thGD1550 lethal (with Df(3L)brm11) thS030605 thS048915 thS062611 thS073601 thS106503 lethal (with Df(3L)st-f13) thS030605 thS048915 thS060404 thS062611 thS073601 lethal | embryonic stage th5 lethal | embryonic stage, with tha.cIa thcIa lethal | embryonic stage, with thcIa tha.cIa lethal | larval stage | recessive thS030605 thS062611 lethal | pupal stage th4 lethal | pupal stage, with Scer\GAL4GMR.PF thdsRNA.Scer\UAS.cLa lethal | pupal stage | heat sensitive thdsRNA.hs lethal | pupal stage | recessive thS030605 lethal | recessive th4 th5 th6B th7 th9 th11-3e th23-4s th23-8s th81.03 th109.07 th228 th293 thI1 thj5C8 thS048915 thS060404 thS062611 thS073601 thS106503 semi-lethal | recessive th6-3s th21-2s th45-2s th355 thS030605 thS060404 viable thEY07925 thSL viable (with th4) th21-2s viable (with th5) th21-2s viable (with th6B) th21-2s viable (with th7) th21-2s viable (with th21-2s) th4 th5 th6B th7 Sterility Allele female sterile (with th6B) th8 female sterile (with th8) th6B fertile thEY07925 male sterile thN21G.N22V.αTub84B.T:Mmus\Cd8a.T:Disc\RFP-mRFP.T:SV40\nls2.T:Avic\GFP-EGFP Other Phenotypes Allele cell death defective | recessive th5 cell shape defective thT:Ivir\HA1 cell shape defective, with Scer\GAL4Act5C.PI thScer\UAS.T:Hsap\MYC decreased cell death thC.IE1 thD20A.D201A.E205A.IE1 thD20A.D201A.IE1 thD20A.E205A.IE1 thD20A.IE1 thD201A.E205A.IE1 thD201A.IE1 thE205A.IE1 thIE1.PM eye color defective, with Scer\GAL4GMR.PF thdsRNA.Scer\UAS.cLa gravitaxis behavior defective th1 increased cell death th1 th4 th5 thdsRNA.406-1319 thdsRNA.cZa thRING.GMR increased cell death, with Scer\GAL434B thdsRNA.Scer\UAS thScer\UAS.cHa increased cell death, with Scer\GAL4GMR.PF thdsRNA.Scer\UAS increased cell death, with tha.cIa thcIa increased cell death, with thcIa tha.cIa increased cell death | conditional th7 increased cell death | heat sensitive thdsRNA.hs increased cell death | recessive th109.07 increased cell death | somatic clone th22-8S increased cell death | third instar larval stage, with Scer\GAL4GMR.PF thdsRNA.Scer\UAS.cLb neuroanatomy defective th4 th6-3s neuroanatomy defective, with Scer\GAL4C57 thScer\UAS.cBa neuroanatomy defective, with Scer\GAL4ppk.1.9 thScer\UAS.cHa visible thdsRNA.GMR thmiRNA.GMR thRING.GMR thunspecified visible, with Scer\GAL4GMR.PF thdsRNA.Scer\UAS.cLa thdsRNA.Scer\UAS.cLb thdsRNA.Scer\UAS visible, with Scer\GAL4GMR.PU thdsRNA.Scer\UAS visible, with Scer\GAL4sca-P309 thScer\UAS.cHa visible | recessive th1 wild-type (with Dp(3;Y)L131-D3), with Df(3L)th102 th1 Phenotype manifest in Allele antennal disc | third instar larval stage th1 arista th1 thunspecified arista (with Df(3L)th102) th1 arista lateral th1 arista lateral (with Df(3L)th102) th1 arista lateral | ectopic, with Scer\GAL4T80 thScer\UAS.cHa border follicle cell (with th4) th21-2s border follicle cell (with th5) th21-2s border follicle cell (with th7) th21-2s border follicle cell (with th21-2s) th4 th5 th7 border follicle cell | somatic clone th21-2s th4 th5 thj5C8 thPBac2148 dendrite th6-3s dendrite, with Scer\GAL4ppk.1.9 thScer\UAS.cHa dorsal multidendritic neuron ddaC, with Scer\GAL4ppk.1.9 thScer\UAS.cHa egg chamber (with th5) th21-2s egg chamber (with th6B) th21-2s th8 egg chamber (with th8) th6B egg chamber (with th21-2s) th5 th6B embryo th109.07 th11-3e th5 th7 th81.03 th9 thunspecified embryonic/larval midgut | heat sensitive thdsRNA.hs embryonic/larval proventriculus | heat sensitive thdsRNA.hs embryonic/larval salivary gland, with Scer\GAL4SG thScer\UAS.cYa embryonic/larval salivary gland | heat sensitive thdsRNA.hs embryonic epidermis th5 embryonic mandibular segment, with Scer\GAL4wg.PM thScer\UAS.cHa embryonic maxillary segment, with Scer\GAL4wg.PM thScer\UAS.cHa embryonic procephalic segment, with Scer\GAL4wg.PM thScer\UAS.cHa eye thmiRNA.GMR thdsRNA.GMR thBIR.GMR thRING.GMR eye, with Scer\GAL4GMR.PF thdsRNA.Scer\UAS thdsRNA.Scer\UAS.cLa thdsRNA.Scer\UAS.cLb eye, with Scer\GAL4GMR.PU thdsRNA.Scer\UAS eye | conditional th7 eye | P-stage thGMR.PH eye-antennal disc thRING.GMR eye disc | third instar larval stage, with Scer\GAL4GMR.PF thdsRNA.Scer\UAS.cLb follicle cell | somatic clone thj5C8 follicle cell | supernumerary (with th5) th21-2s follicle cell | supernumerary (with th21-2s) th5 gastric caecum | heat sensitive thdsRNA.hs interommatidial bristle, with Scer\GAL4GMR.PF thdsRNA.Scer\UAS.cLb macrochaeta, with Scer\GAL4sca-109-68 thdsRNA.cOa.Scer\UAS macrochaeta | supernumerary, with Scer\GAL4sca-P309 thScer\UAS.cHa minor mitochondrial derivative thC422Y.βTub85D neuron th4 th6-3s neuron | embryonic stage thdsRNA.cIa nurse cell | supernumerary (with th5) th21-2s nurse cell | supernumerary (with th6B) th21-2s nurse cell | supernumerary (with th21-2s) th5 th6B ommatidial precursor cluster, with Scer\GAL4GMR.PF thScer\UAS.cHa ovariole (with th6B) th8 ovariole (with th8) th6B ovary (with th6B) th8 ovary (with th8) th6B pigment cell thGMR.PH thRING.GMR pigment cell, with Scer\GAL4GMR.PF thdsRNA.Scer\UAS thdsRNA.Scer\UAS.cLa presumptive embryonic/larval peripheral nervous system thdsRNA.cIa sensory mother cell | supernumerary, with Scer\GAL4sca-P309 thScer\UAS.T:Zzzz\FLAG spermatid thC422Y.βTub85D synapse, with Scer\GAL4C57 thScer\UAS.cBa testis thN21G.N22V.αTub84B.T:Mmus\Cd8a.T:Disc\RFP-mRFP.T:SV40\nls2.T:Avic\GFP-EGFP thD20A.αTub84B.T:Mmus\Cd8a.T:Disc\RFP-mRFP.T:SV40\nls2.T:Avic\GFP-EGFP ventral nerve cord thdsRNA.cIa waste bag thC422Y.βTub85D wing disc | posterior compartment | somatic clone th22-8S
Classical Alleles ( 78 )
For All Classical Alleles Show
Allele of th Class Mutagen Stocks Known lesion th1 loss of function allele spontaneous 226 -- th4 amorphic allele - genetic evidence, loss of function allele 2 Yes thj5C8 P-element activity 2 Yes th5-HA-1820 1 -- th5-HA-1837 1 -- th5-HA-2788 1 -- thc06094 piggyBac transposase 1 -- thc06574 piggyBac transposase 1 -- thCB-6230-3 1 -- thCB-6536-3 1 -- thd00070 P-element activity 1 -- thDG29603 P-element activity 1 -- the02749 piggyBac transposase 1 -- the03559 piggyBac transposase 1 -- thEY00710 P-element activity 1 -- thEY07925 P-element activity 1 -- thEY20302 P-element activity 1 -- thf01746 piggyBac transposase 1 -- thI1 1 -- thNP0547 1 -- thNP0826 1 -- thNP0857 1 -- thNP0913 1 -- thNP0943 1 -- thNP2052 1 -- thNP2089 1 -- thNP2716 1 -- thNP4458 1 -- thNP5450 1 -- thNP6632 1 -- thUM-8002-3 1 -- thUM-8356-3 1 -- th109.07 loss of function allele ethyl methanesulfonate 0 Yes th11-3e 0 Yes th21-2s 0 Yes th21-4s 0 Yes th22-8S 0 Yes th228 P-element activity 0 Yes th23-4s 0 Yes th23-8s 0 Yes th293 X ray 0 -- th33-1s 0 Yes th355 P-element activity 0 Yes th3 gamma ray spontaneous 0 -- th45-2s 0 Yes th5-HA-1225 0 -- th5-HA-2913 0 -- th5 loss of function allele 0 Yes th6-3s 0 Yes th6 hypomorphic allele - genetic evidence 0 -- th6B gain of function allele 0 Yes th7 loss of function allele 0 Yes th81.03 gain of function allele ethyl methanesulfonate 0 Yes th8 0 -- th9 loss of function allele ethyl methanesulfonate 0 Yes thd07257 P-element activity 0 -- thd11177 P-element activity 0 -- thd11655 P-element activity 0 -- thEP.M P-element activity 0 Yes thEP3279 P-element activity 0 Yes thEP3308 0 Yes thEP3451 P-element activity 0 -- thEP3501 P-element activity 0 -- thEP3723 P-element activity 0 -- thEP852 P-element activity 0 -- thGS3057 0 -- thGS9038 0 Yes thPBac2148 piggyBac transposase 0 Yes thS030605 Delta2-3 P-element activity 0 -- thS048915 Delta2-3 P-element activity 0 -- thS060404 Delta2-3 P-element activity 0 -- thS062611 Delta2-3 P-element activity 0 -- thS073601 Delta2-3 P-element activity 0 -- thS106503 Delta2-3 P-element activity 0 -- thSL hypermorphic allele - genetic evidence, loss of function allele, gain of function allele ethyl methanesulfonate 0 Yes thSS107 X ray 0 -- thSS108 X ray 0 -- thunspecified ethyl methanesulfonate 0 --
Alleles Carried on Transgenic Constructs ( 97 )
For All Alleles Carried on Transgenic Constructs Show
Allele of th Class Mutagen Stocks Known lesion thN21G.N22V.Scer\UAS.T:Mmus\Cd8a.T:Disc\RFP-mRFP.T:SV40\nls2.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - site directed mutagenesis 3 Yes thGMR.PH in vitro construct - regulatory fusion 1 Yes thHMS00752 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes thScer\UAS.cHa in vitro construct - regulatory fusion 1 Yes th21-438.Act5C.T:Uuuu\Ub in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes th21-4s.MtnA.T:Sjap\GST in vitro construct - amino acid replacement 0 Yes th23-4s.MtnA.T:Sjap\GST in vitro construct - site directed mutagenesis 0 Yes th4.MtnA.T:Sjap\GST in vitro construct - site directed mutagenesis 0 Yes th6-3s.MtnA.T:Sjap\GST in vitro construct - site directed mutagenesis 0 Yes th6B.Act5C.T:Ivir\HA1 in vitro construct - amino acid replacement 0 Yes th7.Act5C.T:Ivir\HA1 in vitro construct - deletion 0 Yes tha.cIa in vitro construct - RNAi in vitro construct 0 Yes thAct5C.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes thAct5C.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - coding region fusion 0 Yes thBIR.GMR in vitro construct - deletion 0 Yes thBIR1.11-3.MtnA.T:Sjap\GST in vitro construct - site directed mutagenesis 0 Yes thBIR1.MtnA.T:Sjap\GST in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes thBIR2.MtnA.T:Sjap\GST in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes thC.IE1 in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes thC406Y.αTub84B in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes thC422Y.βTub85D in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes thcIa in vitro construct - RNAi in vitro construct 0 Yes thD201A.E205A.IE1 in vitro construct - site directed mutagenesis 0 Yes thD201A.IE1 in vitro construct - site directed mutagenesis 0 Yes thD20A.Act5C.T:Ivir\HA1 in vitro construct - amino acid replacement 0 Yes thD20A.C406Y.αTub84B in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes thD20A.D201A.E205A.IE1 in vitro construct - site directed mutagenesis 0 Yes thD20A.D201A.IE1 in vitro construct - site directed mutagenesis 0 Yes thD20A.E205A.IE1 in vitro construct - site directed mutagenesis 0 Yes thD20A.IE1 in vitro construct - site directed mutagenesis 0 Yes thD20A.αTub84B.T:Mmus\Cd8a.T:Disc\RFP-mRFP.T:SV40\nls2.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - site directed mutagenesis 0 Yes thD20A.αTub84B in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes thDQVA.Act5C.T:Hsap\MYC,T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes thdsRNA.1-700 in vitro construct - RNAi 0 Yes thdsRNA.406-1319 in vitro construct - RNAi 0 Yes thdsRNA.a in vitro construct - RNAi 0 Yes thdsRNA.b in vitro construct - RNAi 0 Yes thdsRNA.c in vitro construct - RNAi 0 Yes thdsRNA.cIa in vitro construct - RNAi 0 Yes thdsRNA.cLa in vitro construct - RNAi 0 Yes thdsRNA.cOa.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes thdsRNA.cZa in vitro construct - RNAi 0 Yes thdsRNA.d in vitro construct - RNAi 0 Yes thdsRNA.e in vitro construct - RNAi 0 Yes thdsRNA.f in vitro construct - RNAi 0 Yes thdsRNA.GMR in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes thdsRNA.hs in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes thdsRNA.Scer\UAS.cLa in vitro construct - regulatory fusion in vitro construct - RNAi 0 -- thdsRNA.Scer\UAS.cLb in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes thdsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes thE205A.IE1 in vitro construct - site directed mutagenesis 0 Yes thGD1550 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes thie1.23-4s.T:Zzzz\FLAG in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes thie1.4.T:Zzzz\FLAG in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes thie1.5.T:Zzzz\FLAG in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes thie1.6-3s.T:Zzzz\FLAG in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes thIE1.PJ in vitro construct - regulatory fusion 0 Yes thIE1.PM in vitro construct - regulatory fusion 0 Yes thlinker1.MtnA.T:Sjap\GST in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes thlinker2.MtnA.T:Sjap\GST in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes thmiRNA.GMR in vitro construct - regulatory fusion 0 Yes thmiRNA.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes thMtnA.H.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes thMtnA.PQ in vitro construct - regulatory fusion 0 Yes thMtnA.PW in vitro construct - regulatory fusion 0 Yes thMtnA.T:Disc\RFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes thMtnA.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes thMtnA.T:Sjap\GST in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes thMtnA.T:Zzzz\TAP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes thN.21-438.αTub84B in vitro construct - regulatory fusion 0 Yes thN.IE1 in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes thN117K.H283Y.Scer\UAS.T:Avic\GFP-YFP.Venus in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - site directed mutagenesis 0 Yes thN21G.Act5C.T:Hsap\MYC,T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes thN21G.Act5C.T:Ivir\HA1 in vitro construct - amino acid replacement 0 Yes thN21G.N22V.αTub84B.T:Mmus\Cd8a.T:Disc\RFP-mRFP.T:SV40\nls2.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - site directed mutagenesis 0 Yes thN21M.21-438.αTub84B in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes thRING.GMR in vitro construct - deletion 0 Yes thRING.MtnA.T:Sjap\GST in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes thRINGm in vitro construct 0 Yes thScer\UAS.cBa in vitro construct - regulatory fusion 0 Yes thScer\UAS.cLa in vitro construct - regulatory fusion 0 Yes thScer\UAS.cMa in vitro construct - regulatory fusion 0 Yes thScer\UAS.cMb in vitro construct - regulatory fusion 0 Yes thScer\UAS.cYa in vitro construct - regulatory fusion 0 Yes thScer\UAS.P\T.cPa in vitro construct - regulatory fusion 0 Yes thScer\UAS.T:Avic\GFP-YFP.Venus in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes thScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion 0 Yes thScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion 0 Yes thScer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes thT:Ivir\HA1 in vitro construct - coding region fusion 0 Yes thV85M.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes thwt.Act5C in vitro construct - coding region fusion 0 Yes thwt.T:Hsap\MYC in vitro construct - coding region fusion 0 Yes thWT.T:Zzzz\TAP in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes thαTub84B.WT in vitro construct - regulatory fusion 0 Yes thΔBIR.MtnA.T:Sjap\GST in vitro construct - deletion 0 Yes thΔRING.MtnA.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)brm11 (Cooper and Kennison, 2011, Melendez et al., 1995, Szeged Stock Center, 1998-, Wang et al., 1999, Colussi et al., 2000) Df(3L)BSC443 (Cooper and Kennison, 2011) Df(3L)BSC774 (Cooper and Kennison, 2011) Df(3L)G63 (Muller et al., 1999) Df(3L)st-f13 (Cooper and Kennison, 2011, Melendez et al., 1995, Szeged Stock Center, 1998-, Spradling et al., 1999, Colussi et al., 2000, BDGP Project Members, 1994-1999, Deak et al., 1997) Df(3L)st-g24 (Cooper and Kennison, 2011) Df(3L)th1 (Velissariou and Ashburner, 1981, Ashburner et al., 1981) Df(3L)th2 (Velissariou and Ashburner, 1981) Df(3L)th45 (Velissariou and Ashburner, 1981) Df(3L)th70i (Korge, 1972) Df(3L)th70kI (Korge, 1972) Df(3L)th70kII (Korge, 1972) Df(3L)th70l (Korge, 1972) Df(3L)th102 (Cooper and Kennison, 2011, Melendez et al., 1995, Velissariou and Ashburner, 1981, Kennison, 1995.6.21) Df(3L)th105 (Ward and Alexander, 1957) Df(3L)th112 (Velissariou and Ashburner, 1981) Df(3L)th113 (Velissariou and Ashburner, 1981) Df(3L)th117 (Cooper and Kennison, 2011, Melendez et al., 1995, Velissariou and Ashburner, 1981, Kennison, 1995.6.21) Tp(3;3)th100.293 (Ward and Alexander, 1957)
Not disrupted in	Df(3L)A5 (Melendez et al., 1995) Df(3L)A27 (Melendez et al., 1995) Df(3L)BK10 (Melendez et al., 1995) Df(3L)Brd6 (Melendez et al., 1995) Df(3L)Brd20 (Melendez et al., 1995) Df(3L)DTS5-3 (Velissariou and Ashburner, 1981) Df(3L)DTS5-4 (Velissariou and Ashburner, 1981) Df(3L)Q26 (Melendez et al., 1995) Df(3L)st2 (Velissariou and Ashburner, 1981) Df(3L)st3 (Velissariou and Ashburner, 1981) Df(3L)st4 (Spradling et al., 1999, Velissariou and Ashburner, 1981, BDGP Project Members, 1994-1999) Df(3L)st6 (Velissariou and Ashburner, 1981) Df(3L)st7 (Velissariou and Ashburner, 1981) Df(3L)st103 (Velissariou and Ashburner, 1981) Df(3L)st106 (Velissariou and Ashburner, 1981) In(3L)st5 (Velissariou and Ashburner, 1981)
Duplicated in	Ts(YLt;3Lt)I   Ts(YSt;3Lt)ST1 (Lindsley and Zimm, 1992, Brizuela et al., 1994)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1550} NA P{TRiP.HMS00752} NA P{UAS-Apoliner} NA P{UAS-DIAP1.dsRNA} NA P{UAS-DIAP1.H} NA P{UASp-th.P} NA P{UAS-th.B} NA P{UAS-th.FLAG} NA P{UAS-th.L} NA P{UAS-th.M} NA P{UAS-th.Mb} NA P{UAS-th.miRNA} NA P{UAS-th.MYC} NA P{UAS-th.RNAi.L} NA P{UAS-th.RNAi} NA P{UAS-th.T:HA1} NA P{UAS-th.V85M} NA P{UAS-th.Y} NA heat-shock construct P{hs-th.RNAi} NA characterization construct P{GMR-DIAP1} NA P{GMR-DIAP1-BIR} NA P{GMR-DIAP1-RING} NA P{GMR-th.miRNA} NA P{GMR-th.RNAi} NA P{Tub-Apoliner} NA P{Tub-Apomut} NA P{tub-DIAP1.21-438} NA P{Tub-DIAP1.C422Y} NA P{tub-DIAP1.N21M.21-438} NA P{tub-DIAP1C406Y} NA P{tub-DIAP1D20A.C406Y} NA P{tub-DIAP1D20A} NA P{tub-DIAP1wt} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}l(3)SH040SH040 No P{lacW}S060404a No P{lacW}thj5C8 No P{lacW}thS030605 No P{lacW}thS048915 No P{lacW}thS062611 No P{lacW}thS073601 No P{lacW}thS106503 No insertion of mobile activating element P{EP}thEP852 NA P{EP}thEP3279 NA P{EP}thEP3308 NA P{EP}thEP3451 NA P{EP}thEP3501 NA P{EP}thEP3723 NA P{EPgy2}thEY00710 NA P{EPgy2}thEY07925 NA P{EPgy2}thEY20302 NA P{GMR}th228 NA P{GMR}th355 NA P{GSV1}MbsGS3057 NA P{GSV6}thGS9038 NA P{XP}thd00070 NA P{XP}thd07257 NA P{XP}thd11177 NA P{XP}thd11655 NA miscellaneous insertions P{EP.Scer\UAS(loxP.Scer\UAS.y+).BN}thEP.M NA P{RS3}thCB-6230-3 NA P{RS3}thCB-6536-3 NA P{RS3}thUM-8002-3 NA P{RS3}thUM-8356-3 NA P{RS5}th5-HA-1225 NA P{RS5}th5-HA-1820 NA P{RS5}th5-HA-1837 NA P{RS5}th5-HA-2788 NA P{RS5}th5-HA-2913 NA P{wHy}thDG29603 NA PBac{IRES-GFP.GT}thPBac2148 NA PBac{PB}thc06094 NA PBac{PB}thc06574 NA PBac{RB}the02749 NA PBac{RB}the03559 NA PBac{WH}thf01746 NA insertion of enhancer trap binary system P{GawB}thNP0547 No P{GawB}thNP0826 No P{GawB}thNP0857 No P{GawB}thNP0913 No P{GawB}thNP0943 No P{GawB}thNP2052 No P{GawB}thNP2089 No P{GawB}thNP2716 No P{GawB}thNP4458 No P{GawB}thNP5450 No P{GawB}thNP6632 No
Gene Ontology: Function, Process & Cellular Component ( 23 unique terms )
Terms Based on Experimental Evidence ( 16 terms )
Molecular Function
CV term Evidence References
enzyme binding inferred from physical interaction with CG7375 (Broemer et al., 2010) NEDD8 ligase activity inferred from direct assay (Broemer et al., 2010) protein binding inferred from physical interaction with ik2 (Kuranaga et al., 2006)
Biological Process
CV term Evidence References
antennal morphogenesis inferred from mutant phenotype (Cullen and McCall, 2004) anti-apoptosis inferred from direct assay (Hawkins et al., 1998) inferred from genetic interaction with W AND inferred from genetic interaction with rpr (Goyal et al., 2000) apoptotic process inferred from physical interaction with W AND inferred from physical interaction with rpr (Goyal et al., 2000) border follicle cell migration inferred from genetic interaction with Rac1 AND inferred from mutant phenotype (Geisbrecht and Montell, 2004) inferred from mutant phenotype (Mathieu et al., 2007) cellular process inferred from mutant phenotype (Boutros et al., 2004) chaeta morphogenesis inferred from mutant phenotype (Koto et al., 2009) negative regulation of apoptosis inferred from mutant phenotype AND inferred from sequence or structural similarity (Hay et al., 1996) negative regulation of compound eye retinal cell programmed cell death inferred from mutant phenotype (Leulier et al., 2006) negative regulation of cysteine-type endopeptidase activity involved in apoptotic process inferred from genetic interaction with Ark (Leulier et al., 2006) inferred from genetic interaction with Ice (Leulier et al., 2006) inferred from genetic interaction with Nc (Leulier et al., 2006) positive regulation of protein ubiquitination inferred from direct assay (Ditzel et al., 2008) sensory organ development inferred from mutant phenotype (Kanuka et al., 2005) sensory organ precursor cell division inferred from genetic interaction with ik2 (Koto et al., 2009) spermatid nucleus differentiation inferred from mutant phenotype (Huh et al., 2004)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 11 terms )
Molecular Function
CV term Evidence References
ubiquitin-protein ligase activity traceable author statement (Ditzel and Meier, 2002) zinc ion binding inferred from electronic annotation with InterPro:IPR001841 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
anti-apoptosis non-traceable author statement (Meier et al., 2000, Swiss-Prot Project Members, 1997.2.1) traceable author statement (Gorski and Marra, 2002, Ditzel and Meier, 2002, Tittel and Steller, 2000, Kumar, 2000, Bergmann et al., 2003, Abrams, 1999) apoptotic process non-traceable author statement (Lawen, 2003) traceable author statement (Richardson and Kumar, 2002) germ cell migration traceable author statement (Coffman, 2003) multicellular organismal development traceable author statement (Tittel and Steller, 2000) negative regulation of apoptosis inferred from sequence or structural similarity with UniProtKB:P98170 (FlyBase, 1992-) traceable author statement (Ditzel and Meier, 2002, Abrams, 1999) negative regulation of cysteine-type endopeptidase activity involved in apoptotic process traceable author statement (Kumar and Doumanis, 2000, Richardson and Kumar, 2002, Bergmann et al., 2003) protein monoubiquitination traceable author statement (Ditzel and Meier, 2002) protein ubiquitination involved in ubiquitin-dependent protein catabolic process traceable author statement (Ou et al., 2003, Bergmann et al., 2003)
Cellular Component
CV term Evidence References
intracellular inferred from electronic annotation with InterPro:IPR001370 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions th allele Gene References th1 al (Mglinets and Ivanov, 1975) th4 egr (Igaki et al., 2002) grim (Lisi et al., 2000) rpr (Hay et al., 1995, Lisi et al., 2000, Tenev et al., 2002) W (Hay et al., 1995, Lisi et al., 2000) th5 Ark (Rodriguez et al., 2002) BacA\p35 (Yoo et al., 2002) chic (Geisbrecht and Montell, 2004) grim (Lisi et al., 2000, Rodriguez et al., 2002) morgue (Hays et al., 2002) Nc (Hawkins et al., 2000, Quinn et al., 2000) rpr (Hay et al., 1995, Lisi et al., 2000) W (Hay et al., 1995, Lisi et al., 2000) th6 rpr (Hay et al., 1995) W (Hay et al., 1995) th6B Ark (Rodriguez et al., 2002) grim (Lisi et al., 2000) rpr (Lisi et al., 2000) W (Lisi et al., 2000) th7 BacA\p35 (Jassim et al., 2003) rpr (Hay et al., 1995) W (Hay et al., 1995) th8 Ark (Rodriguez et al., 2002) th11-3e rpr (Goyal et al., 2000) W (Goyal et al., 2000) th21-2s chic (Geisbrecht and Montell, 2004) rpr (Goyal et al., 2000) W (Goyal et al., 2000) th21-4s rpr (Wilson et al., 2002) W (Wilson et al., 2002) th21-438.Act5C.T:Uuuu\Ub rpr (Ditzel et al., 2003) th23-4s rpr (Goyal et al., 2000) W (Goyal et al., 2000) th23-8s rpr (Goyal et al., 2000) W (Goyal et al., 2000) th33-1s rpr (Wilson et al., 2002) W (Wilson et al., 2002) th109.07 grim (Lisi et al., 2000) rpr (Lisi et al., 2000) W (Lisi et al., 2000) th228 rpr (Hay et al., 1997) th355 rpr (Hay et al., 1997) tha.cIa Ark (Igaki et al., 2002) Nc (Igaki et al., 2002) thcIa Ark (Igaki et al., 2002) Nc (Igaki et al., 2002) thdsRNA.406-1319 Ark (Muro et al., 2002) Nc (Muro et al., 2002) thdsRNA.cZa Ark (Zimmermann et al., 2002) thEP3279 Rac1 (Geisbrecht and Montell, 2004) thEP3308 Rac1 (Geisbrecht and Montell, 2004) thGMR.PH aos (Sawamoto et al., 1998) BacA\p35 (Yu et al., 2002) Dfd (Lohmann et al., 2002) Fmr1 (Wan et al., 2000) Nc (Meier et al., 2000, Hawkins et al., 2000, Quinn et al., 2000) Psn (Ye and Fortini, 1999) rpr (Lohmann et al., 2002, Tenev et al., 2002) W (Bergmann et al., 1998) thMtnA.PQ Nc (Quinn et al., 2000) thMtnA.T:Ivir\HA1 Damm (Harvey et al., 2001) thRING.GMR eff (Ryoo et al., 2002) thScer\UAS.P\T.cPa Dcp-1 (Peterson et al., 2003) thScer\UAS.T:Hsap\MYC ss (Adachi-Yamada et al., 2005) thScer\UAS.T:Ivir\HA1 egr (Igaki et al., 2002) grim (Wing et al., 2001) Pvr (Geisbrecht and Montell, 2004) Rac1 (Geisbrecht and Montell, 2004) rpr (Wing et al., 2001, Igaki et al., 2002) W (Wing et al., 2001) thScer\UAS.T:Zzzz\FLAG rpr (Kuranaga et al., 2002) Traf4 (Kuranaga et al., 2002) thSL rpr (Wing et al., 2001) thT:Ivir\HA1 Rac1 (Geisbrecht and Montell, 2004) thwt.Act5C rpr (Ditzel et al., 2003) thWT.T:Zzzz\TAP Dcp-1 (Tenev et al., 2005) unspecified bchs (Mueller et al., 2005) CG5986 (Mueller et al., 2005) debcl (Colussi et al., 2000) Eip78C (Mueller et al., 2005) grim (Lisi et al., 2000, Mueller et al., 2005) H (Mueller et al., 2005) Ice (Muro et al., 2006) ik2 (Oshima et al., 2006) L (Singh et al., 2006) Nc (Xu et al., 2005) nej (Anderson et al., 2005) p53 (Mueller et al., 2005) pbl (Gregory et al., 2007) rho (Sturtevant and Bier, 1995) rpr (Hay et al., 1995, Goyal et al., 2000, Lisi et al., 2000, Mueller et al., 2005) ss (Mglinets and Ivanov, 1975) Uba1 (Pfleger et al., 2007) W (Hay et al., 1995, Goyal et al., 2000, Lisi et al., 2000, Mueller et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65064 DroID - A comprehensive database of gene and protein interactions. • FBgn0260635 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39753
Orthologs
Genome-wide drosophilid orthologs	Dana\GF10661 Dere\GG13502 Dgri\GH15404 Dmoj\GI13007 Dper\GL25100 Dpse\GA11532 Dsec\GM24450 Dsim\GD12518 Dvir\GJ12099 Dwil\GK23971 Dyak\GE22287
Curated drosophilid orthologs	Dpse\GA11532
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL009074-PA Aedes aegypti (mosquito) AGAP007294-PA Anopheles gambiae (mosquito) XP_001121931.1 Apis mellifera (honey bee) XP_001943113.1 Acyrthosiphon pisum (pea aphid) 201532 Branchiostoma floridae (lancelet) BGIBMGA011524-PA Bombyx mori (silk worm) CE08882 Caenorhabditis elegans (worm) CPIJ002102 Culex pipens (mosquito) ENSCSAVP00000014122 Ciona savignyi (sedentary tunicate) LmjF10.1140 Leishmania major (virus) XP_001606017.1 Nasonia vitripennis (wasp) PHUM003922-PA Pediculus humanus (human body louse) XP_975061.1 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13807 NV14467 LH21936 LH20764 ISCW015499 ISCW004187 FBgn0240322 FBgn0239512 FBgn0225933 FBgn0199351 FBgn0184246 FBgn0179313 JGI_V11_58422 FBgn0071583 FBgn0162687 FBgn0135764 FBgn0122876 FBgn0105774 FBgn0087702 CPIJ002102 BGIBMGA011524 ACYPI009246 ACYPI009069 ACYPI004833 ACYPI001005 GB17129 GB12440 IAP7 IAP4 IAP3 IAP1 AGAP012677 PHUM253740 GLEAN_01192
Stocks & Reagents
Stocks Listed in FlyBase ( 265 )
Bloomington	618 th1 6657 w*; P{UAS-DIAP1.H}3 32122 w*; P{UAS-Apoliner}5 5782 w*; P{GMR-DIAP1}1/CyO 1114 C(3)EN, th1 st1
Harvard	- P{XP}thd00070 - PBac{PB}thc06094 - PBac{PB}thc06574 - PBac{RB}the02749 - PBac{RB}the03559 - PBac{WH}thf01746
Kyoto	106209 C(3)EN, th1 st1
	More stocks available...
Genomic Clones ( 2 )
	BACR18K24 BACR25O01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 101 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH15248 GH15335
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT04572 AT14109 AT22874 GH03078 GH09315 GH17643 GH21582 GH25993 GH26121 GM02015 GM10751 LP01716 LP02892 LP03464 LP05801 LP07894 RE02126 RE05424 RE11044 RE11777 RE42509 RH74071 SD01969 SD05857 SD07153 SD07639 SD07863 SD09651 SD16807 SD17047 SD17259 SD21037
Other clones	10760 14853 30630 30912 34010 41973 42522 45134 54569 61649 72319 74080 107971 147367 183079 214343.22 214373.2 bs80h08 CK01.55C.A6 CK01.75C.C10 CK01.75C.G10 CK01.126C.D10 CK01.128D.B8 CK01.146A.A6 EK044835 EK054344 EK059241 EK059257 EK110522 EK119935 EK139264 EK144617 EK146539 EK155559 EK160515 EK173234 EK179835 EK185051 EK201031 EK203836 EK235846 EK236046 EK249923 EK288357 EN10908 EP09926 EP10438 ESG011a.E21_H04 ESG013c.E21_F01 ESG014c.E21_C12 ESG0115c.B21_A02 ESG0118a.B21_E10 IP10066 IP10166 IP10266 RP001011601 RP001014753 RP001015792 RP001015923 RP001016273 RP001020659 RP001024123 RP001038793 RP001040188 RP001048325 RP001050890 RP001051748
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0260635 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39753 46522 249345
Antibody Information
	polyclonal (Geisbrecht and Montell, 2004, Ryoo et al., 2002, Settles and Friesen, 2008)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: th l(3)72CDe (Kennison, 2008.10.30) Source for merge of: th l(3)S030605b l(3)S106503 (Szeged Stock Center, 1998-)
Additional comments
Other Comments
	The 'l(3)72Dc' (th) complementation group comprises 11 EMS-induced mutant alleles. (Cooper and Kennison, 2011) Cleaved th binds to UBR domains and promotes ubiquitination of Ice and Dcp1. (Ditzel et al., 2008) Gene expression is increased in response to the presence of two copies of Scer\GAL4hs.PB. (Liu and Lehmann, 2008) Apoptosis is induced in Kc cells that have been treated with dsRNA made from templates generated with primers directed against this gene. (Colombani et al., 2006) S2 cells treated with dsRNA directed against this gene show a dramatic increase in cell death. (Cherry et al., 2005) RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) th has a role in promoting cell migration in border follicle cells. This effect of th on cell migration is independent of its role in preventing apoptosis, although the effect does result from inhibition of the initiator caspase Nc. (Geisbrecht and Montell, 2004) Loss of function mutations in th result in border follicle cell migration defects. (Geisbrecht and Montell, 2004) th protein is degraded by the "N-end rule" pathway and this process is indispensable for regulating apoptosis. Caspase-mediated cleavage of th protein at position 20 converts the more stable pro-N-degron of th into the highly unstable, Asn-bearing, th N-degron of the N-end rule degradation pathway. (Ditzel et al., 2003) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: cell number is catastrophically reduced. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) th is critical for the induction of apoptosis by rpr and W. (Goyal et al., 2000) rpr, W and grim may kill cells by inhibiting th's ability to antagonise caspase function. (Goyal et al., 2000) th is necessary to block apoptosis very early in embryonic development. This may reflect a requirement to block maternally provided rpr and W function. (Lisi et al., 2000) Domains in addition to the BIR2 domain of the th gene product are required for rpr, grim and W to inactivate th. (Lisi et al., 2000) th interacts with the pro-domain of Nc and appears to be a critical regulator of activation of Nc in vivo. (Meier et al., 2000) The function of the th gene is essential for cell survival. (Wang et al., 1999) th is epistatic to the mutant phenotype of Df(3L)H99 (deleted for rpr, W, and grim). (Wang et al., 1999) th promotes cell survival by blocking the activity of the Dcp-1 gene product. (Wang et al., 1999) The product of th can inhibit mammalian cell death induced by overexpression of caspases 1 and 2. (Hawkins et al., 1998) th mutants exhibit cellularization defects. (Moore et al., 1998) The th protein associates with the tkv receptor in vivo. (Oeda et al., 1998) Identification: Enhancer trap screen designed to discover genes involved in the cellular aspects of defense mechanisms, as well as in melanotic tumor formation processes linked to blood cell disregulation. (Braun et al., 1997) Mutations in th are dominant enhancers of rpr induced cell death. (Hay et al., 1995) Identified during a mutagenesis of the 71F-72D region. (Melendez et al., 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079377 NM_168644 NM_168645 RefSeq (Proteins) • NP_524101 NP_730097 NP_730098 DDBJ / EMBL / GenBank • AA801628 AAC41609 AAF49548 AAG22319 AAM50178 AAN11757 AI258503 AI292436 AQ034091 AQ073145 AQ073878 AQ074017 AQ254653 AW940586 AY119524 AZ300907 BZ748784 CL705817 CZ470495 CZ470824 CZ471363 CZ475620 CZ477599 CZ477846 CZ480521 CZ481316 CZ484213 L49440 Entrez Gene - A searchable database of RefSeq genes. • 39753 UniProtKB/Swiss-Prot • Q24306
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Baculoviral inhibition of apoptosis protein repeat (IPR001370) Zinc finger, RING-type (IPR001841) Zinc finger, RING/FYVE/PHD-type (IPR013083) PDB - Protein Data Bank. An information portal to biological macromolecular structures • 1JD4 1JD5 1JD6
Linkouts
	BioGRID - A database of protein and genetic interactions • 65064 DroID - A comprehensive database of gene and protein interactions. • FBgn0260635 DRSC - Results from RNAi screens. • FBgn0260635 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0260635 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0260635 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 92747 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39753 46522 249345 InParanoid A subset of ortholog calls from InParanoid. • AAEL009074-PA Aedes aegypti (mosquito) AGAP007294-PA Anopheles gambiae (mosquito) XP_001121931.1 Apis mellifera (honey bee) XP_001943113.1 Acyrthosiphon pisum (pea aphid) 201532 Branchiostoma floridae (lancelet) BGIBMGA011524-PA Bombyx mori (silk worm) CE08882 Caenorhabditis elegans (worm) CPIJ002102 Culex pipens (mosquito) ENSCSAVP00000014122 Ciona savignyi (sedentary tunicate) LmjF10.1140 Leishmania major (virus) XP_001606017.1 Nasonia vitripennis (wasp) PHUM003922-PA Pediculus humanus (human body louse) XP_975061.1 Tribolium castaneum (red flour beetle) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /newgene/thread1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39753 modMine - Data generated by the modENCODE project. • FBgn0260635 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13807 NV14467 LH21936 LH20764 ISCW015499 ISCW004187 FBgn0240322 FBgn0239512 FBgn0225933 FBgn0199351 FBgn0184246 FBgn0179313 JGI_V11_58422 FBgn0071583 FBgn0162687 FBgn0135764 FBgn0122876 FBgn0105774 FBgn0087702 CPIJ002102 BGIBMGA011524 ACYPI009246 ACYPI009069 ACYPI004833 ACYPI001005 GB17129 GB12440 IAP7 IAP4 IAP3 IAP1 AGAP012677 PHUM253740 GLEAN_01192
Synonyms & Secondary IDs ( 59 )
Reported As
Symbol Synonym	0736/01 (Deak et al., 1997) 1065/03 (Deak et al., 1997) CG12284 (Bellen et al., 2004, Laviolette et al., 2005, Quinones-Coello, 2007, Chen et al., 2008, Ni et al., 2010.12.1, Ying et al., 2011) Diap (Garcia-Lopez et al., 2008, Classen et al., 2009) DIAP (Gagic and Mueller, 2004, Finelli et al., 2002, White, 1999, Jang et al., 2008, Lee et al., 2006, Kondo et al., 2009, Neisch et al., 2010) dIAP (White, 2000) diap (Silva, 2006, Resnik-Docampo and de Celis, 2011) DIAP1 (Zhao et al., 2008, Bedoukian et al., 2009, Baum et al., 2007, Herman-Bachinsky et al., 2007, Doumanis et al., 2001, Delanoue et al., 2004, Cordero and Cagan, 2010, Li et al., 2011, Guan et al., 2007, Lee et al., 2007, Kondo et al., 2006, Vidal and Cagan, 2006, Anderson et al., 2005, Mueller et al., 2005, Dotto and Silke, 2004, Udan et al., 2003, Pantalacci, 2003, Coffman, 2004, Tenev et al., 2005, Adachi-Yamada et al., 2005, Lai et al., 2005, Yokokura et al., 2004, Meier and Silke, 2003, Pantalacci et al., 2003, Hay and Guo, 2003, Shiozaki and Shi, 2004, Levine, 2004, Huh et al., 2004, Moberg and Hariharan, 2003, Holcik, 2002, Abrams, 1999, Tomioka et al., 2005, Guan et al., 2005, Gagic et al., 2005, Xu et al., 2004, Yeo and Gautier, 2004, Geisbrecht and Montell, 2004, Igaki and Miura, 2004, Zachariou et al., 2003, Morey et al., 2003, Kessler and Muller, 2003, Gagic and Muller, 2003, Nijhout, 2003, Varfolomeev and Ashkenazi, 2004, Danial and Korsmeyer, 2004, Huh et al., 2004, Olson et al., 2003, Bach et al., 2003, Yokokura et al., 2004, Udan et al., 2004, Ryoo et al., 2004, Kessler and Mueller, 2004, Jia et al., 2004, Hays, 2004, Harvey et al., 2004, Giot et al., 2003, Hidalgo and ffrench-Constant, 2003, Ilangovan et al., 2003, Jaklevic and Su, 2003, Rothenberg and Jan, 2003, Jia et al., 2003, Harvey et al., 2003, Kuranaga et al., 2002, Varshavsky, 2003, Ryoo et al., 2002, Ou et al., 2003, Ditzel et al., 2003, Olson et al., 2003, Zimmermann et al., 2002, Wing et al., 2002, Hays et al., 2002, Yoo et al., 2002, Wu et al., 2001, Gozani et al., 2002, Hu and Yang, 2003, Palaga and Osborne, 2002, Wilson et al., 2002, Holley et al., 2002, Schreader et al., 2003, Yokokura et al., 2003, Kuranaga et al., 2003, Tenev et al., 2002, Alonso, 2002, Abrams, 2002, Luque et al., 2002, Tapon et al., 2002, Huh and Hay, 2002, Martin, 2002, Vaux and Korsmeyer, 1999, Jackson et al., 2002, Igaki et al., 2002, Yu et al., 2002, Srinivasula et al., 2002, Wright and Clem, 2002, Srinivasula et al., 2002, Silke and Vaux, 2001, Meier et al., 2000, Bangs et al., 2001, Vernooy et al., 2000, Vernooy et al., 2000, Reed and Bischoff, 2000, Vernooy et al., 2000, Hawkins et al., 2000, Steller, 2000, Jones et al., 2000, Takatsu et al., 2000, Lisi et al., 2000, Song and Steller, 1999, Song and Steller, 1999, Song and Steller, 1999, Meier et al., 2000, Hay, 1996.1.5, Ye and Fortini, 1999, Wang et al., 1999, Hawkins et al., 1999, LaCasse et al., 1998, Bergmann et al., 1998, Oeda et al., 1998, Foley and Cooley, 1998, Wing and Nambu, 1998, Clem and Duckett, 1997, McCall and Steller, 1997, Chinnaiyan and Dixit, 1996, Hay et al., 1995, Hays, 2006, Hamaratoglu et al., 2006, Muro, 2005, Koto et al., 2007, Reuveny and Volk, 2007, Caldwell and Eberl, 2007, Ribeiro et al., 2007, Harvey and Bennett, 2007, Thompson and Cohen, 2006, Janody and Treisman, 2006, Colombani et al., 2006, Colombani et al., 2006, Moreno et al., 2002, Adrain, 2006, Oshima et al., 2006, Oshima, 2006, Kuranaga et al., 2006, Otsuki et al., 2004, Pfleger et al., 2007, Igaki et al., 2007, Meyer et al., 2006, Sasaki et al., 2007, Kuranaga and Miura, 2007, Sugiyama et al., 2007, Hirose et al., 2001, Mueller et al., 2006, Li and Cadigan, 2008, Martin et al., 2008, Mathieu et al., 2007, Freel et al., 2008, Kornbluth and White, 2005, Abdelwahid et al., 2005, Wech and Nagel, 2005, Song et al., 2007, Wu et al., 2007, Challa et al., 2007, Abdelwahid et al., 2007, Link et al., 2007, Yi et al., 2007, Yin et al., 2007, Scott et al., 2007, Polesello and Tapon, 2007, Sato et al., 2008, Morey et al., 2003, Means et al., 2006, Bejarano et al., 2008, Mehrotra et al., 2008, Chandraratna et al., 2007, Pellock et al., 2007, Caldwell et al., 2008, Hamaratoglu et al., 2006, Kessler and Müller, 2009, Scott et al., 2007, Khan et al., 2008, Hong et al., 2009, Ditzel et al., 2008, Lee et al., 2009, Ribaya et al., 2009, Hamaratoglu et al., 2009, Chew et al., 2009, Gesellchen et al., 2005, Zhang et al., 2009, Szuplewski et al., 2009, Branco et al., 2008, Arya and Lakhotia, 2008, Koto et al., 2009, Grieder et al., 2009, Kuo et al., 2006, Mallik and Lakhotia, 2009, Leulier et al., 2006, Genevet et al., 2009, Hilgers et al., 2010, Guo et al., 2003, Bader et al., 2010, Harvey et al., 1997, Yavari et al., 2010, Bardet et al., 2008, Milton et al., 2010, Nezis et al., 2010, Cully et al., 2010, Arya et al., 2010, Williams et al., 2006, Neto-Silva et al., 2010, Bakhrat et al., 2010, Broemer et al., 2010, Malzer et al., 2010, Shen et al., 2009, Liu et al., 2010, Shukla and Tapadia, 2011, Tao and Rolls, 2011, Sandu et al., 2010, Awasaki et al., 2006, Vandergaast et al., 2011, Yan et al., 2004, Lannan et al., 2007, Gilbert et al., 2011, Yang et al., 2010) diap1 (Richter et al., 2011, Vidal et al., 2006, Yin et al., 2007, Yu et al., 2008, Shimizu et al., 2008, Ohayon et al., 2009, Peterson et al., 2007, Matova and Anderson, 2010, Fernández et al., 2011, Wang et al., 2010, Xu et al., 2005, Huang et al., 2005, Yin and Thummel, 2004, Xu et al., 2005, Hay et al., 2004, Ryoo and Steller, 2003, Bergmann et al., 2003, Yin et al., 2004, Tittel and Steller, 2000, Ditzel and Meier, 2002, Muro et al., 2002, Ryoo et al., 2002, Igaki et al., 2002, Yin and Thummel, 2003, Gorski and Marra, 2002, Bialik and Gottlieb, 2000, Wing et al., 2001, Hsu and Schulz, 2000, Kumar and Doumanis, 2000, Buszczak and Segraves, 2000, Quinn et al., 2000, Pecasse et al., 2000, Colussi et al., 2000, Goyal et al., 2000, White et al., 1999, Kanuka et al., 1999, Bergmann et al., 1998, Agapite et al., 1999, Sawamoto et al., 1998, Jiang et al., 1997, Xu et al., 2006, Bashirullah et al., 2006, Singh et al., 2006, Betz et al., 2007, Choi et al., 2006, Nolo et al., 2006, Ryoo et al., 2004, Hamaratoglu et al., 2007, Gregory et al., 2007, Yoneda et al., 2007, Ganguly et al., 2008, Huh et al., 2007, Montell, 2006, Zhang et al., 2008, Wu et al., 2008, Ling et al., 2010, Muro et al., 2004, Shapiro et al., 2008, Leulier et al., 2006, Xu et al., 2006, Dutta and Baehrecke, 2008, Primrose et al., 2007, Copeland et al., 2007, Chittaranjan et al., 2009, Creagh et al., 2009, Dorstyn and Kumar, 2008, Betz et al., 2008, Willecke et al., 2008, Zhang et al., 2008, Martín et al., 2009, Doumanis et al., 2009, Tanaka-Matakatsu et al., 2007, Kondo et al., 2009, Das Thakur et al., 2010, Grzeschik et al., 2010, Robinson et al., 2010, Ribeiro et al., 2007, Yu et al., 2010, Baumgartner et al., 2010, Genevet et al., 2010, Sekyrova et al., 2010, Menéndez et al., 2010, Chen et al., 2010, Wang et al., 2008, Nicolay et al., 2010, Benitez et al., 2010, Yan et al., 2011, Settles and Friesen, 2008) DIAP-1 (Hawkins et al., 1998, Zheng et al., 2005, Baum et al., 2005, Peterson et al., 2003, Brachmann and Cagan, 2003, Wang, 2001, Zapata et al., 2000, Massague, 2000, Kaiser et al., 1998, Meier and Evan, 1998, Edgar, 2006, Goyal et al., 2007, Szuplewski et al., 2009) dIAP1 (Mesquita et al., 2010, Secombe et al., 2004, Bangs et al., 2000, Kurada and White, 1998, Wang et al., 2006, Tsujimura et al., 2008, Morris et al., 2006, Rimkus et al., 2008, Saleh et al., 2006, Froldi et al., 2010, Rhiner et al., 2010) Diap-1 (Wells, 2002, Lawen, 2003, Cagan, 2003, Hays et al., 2002, Mislak et al., 2007) Diap1 (Kumar and Cakouros, 2004, Jassim et al., 2003, Baehrecke, 2003, Kramer et al., 2003, Kumar, 2000, Claveria and Torres, 2003, Rodriguez et al., 2002, Harvey et al., 2001, Chen and Abrams, 2000, Uren et al., 1998, Herz, 2006, Wells et al., 2006, Herz et al., 2006, Bergmann, 2006, Volk and Reuveny, 2007, Silva et al., 2006, Dong et al., 2007, Hsu et al., 2004, Silva, 2006, Baehrecke, 2006, Pret et al., 2008, Shapiro and Ryoo, 2008, Joza et al., 2008, Rogulja et al., 2008, Lee et al., 2008, Arama et al., 2007, Protzer et al., 2008, Romani et al., 2009, Oh and Irvine, 2009, Tenev et al., 2007, Vicente et al., 2007, Reuveny et al., 2009, Cho et al., 2006, Mao et al., 2009, Wang and Kalderon, 2009, Bejarano et al., 2010, Kim et al., 2010, Baumgartner et al., 2010, Reddy et al., 2010, Vicente-Crespo et al., 2008, Suissa et al., 2011, Rauskolb et al., 2011) D-IAP1 (Boutros et al., 2004, Kiger et al., 2003, Seshagiri et al., 1999, Miller, 1999, Deveraux and Reed, 1999, Vucic et al., 1997) diap-1 (Schuldt, 2000, Peterson et al., 2006, Edgar, 2006, Tanner et al., 2008, Creagh et al., 2009, Baena-Lopez et al., 2008) D-iap1 (Vucic et al., 1998, Vucic et al., 1998) dIAP-1 (Lisi et al., 1998, Li et al., 2002, Rhiner et al., 2009) dIap1 (Wu and Silverman, 2007) diap 1 (Silva, 2006) Diap-1/Th (Moskalev, 2001) diap1/thread (Richardson and Kumar, 2002) DIAPI (Anderson et al., 2005) DIAP I (Muller et al., 2003) E(rpr)3-1   IAP (Adachi-Yamada et al., 2005, Nakayama et al., 2000, Conlan and Raff, 1999, Tyler and Baker, 2007) Iap1 (Liu et al., 2009) IAP1 (Gregory et al., 2007, Latouche et al., 2007, Chew et al., 2009, Sandu et al., 2010) l(3)72CDe (Kennison, 2008.10.30, Cooper and Kennison, 2011) l(3)72Dc (Cooper and Kennison, 2011) l(3)j5C8 (Braun et al., 1997, ) l(3)S030605   l(3)S030605b (Szeged Stock Center, 1998-, ) l(3)S106503   S048915 (Link et al., 2007) th (Garcia-Lopez et al., 2008, Ohayon et al., 2009, Matova and Anderson, 2010, Delanoue et al., 2004, Guan et al., 2007, Balakireva et al., 2006, Mislak et al., 2007, Muro et al., 2006, Janody and Treisman, 2006, Laviolette et al., 2005, Pfleger et al., 2007, Quinones-Coello, 2007, Renault et al., 2004, Wech and Nagel, 2005, Zhang et al., 2008, Hou et al., 2008, Kuo et al., 2006, Chandraratna et al., 2007, Kessler and Müller, 2009, Takahashi and Ting, 2004, Ribaya et al., 2009, Chew et al., 2009, Oh and Irvine, 2008, Cho et al., 2006, Ghosh and Feany, 2004, Branco et al., 2008, Lai et al., 2007, Tanaka-Matakatsu et al., 2007, Kondo et al., 2009, Koto et al., 2009, Morris et al., 2006, Chen et al., 2008, Wang et al., 2008, Milton et al., 2010, Arya et al., 2010, Vicente-Crespo et al., 2008, Terashima and Bownes, 2005, Rauskolb et al., 2011, Cooper and Kennison, 2011, Gilbert et al., 2011)
Name Synonym	degradation of inhibitors of apoptosis (Cordero and Cagan, 2010) DIAP1 (Bennett and Harvey, 2006, Bardet et al., 2008, Willecke et al., 2006) diap1 (Willecke et al., 2006) Drosophila IAP1 (Morey et al., 2003, Koto et al., 2009) Drosophila Inhibitor of Apoptosis (Mislak et al., 2007) Drosophila inhibitor of apoptosis (Caldwell and Eberl, 2007, Edgar, 2006) Drosophila inhibitor of apoptosis 1 (Lee et al., 2007, Baehrecke, 2006, Montell, 2006, Yi et al., 2007, Yin et al., 2007, Rimkus et al., 2008, Caldwell et al., 2008, Betz et al., 2008, Das Thakur et al., 2010, Grzeschik et al., 2010, Robinson et al., 2010, Milton et al., 2010) Drosophila Inhibitor of Apoptosis 1 (Ditzel et al., 2008) Drosophila Inhibitor of Apoptosis Protein (Janody and Treisman, 2006) Drosophila inhibitor of apoptosis protein (Shukla and Tapadia, 2011) Drosophila inhibitor of apoptosis protein 1 (Moreno et al., 2002, Wech and Nagel, 2005, Rhiner et al., 2010) Drosophila inhibitor-of-apoptosis protein 1 (Adrain, 2006) Drosophila Inhibitor of apoptosis protein 1 (Li and Cadigan, 2008, Reddy et al., 2010) Drosophila Inhibitor of Apoptosis Protein-1 (Szuplewski et al., 2009) Drosophila Inhibitor of Apoptosis Protein 1 (Mallik and Lakhotia, 2009) Drosophila thread/inhibitor of apoptosis protein-1 (Morris et al., 2006) inhibitor of apoptosis (Nicolay et al., 2010) Inhibitor of apoptosis 1   inhibitor of apoptosis-1 (Morris et al., 2006) Inhibitor of Apoptosis 1 (Genevet et al., 2010, Froldi et al., 2010) inhibitor of apoptosis protein 1 (Bardet et al., 2008) Inhibitors of Apoptosis protein (Guan et al., 2005) lethal (3) 72CDe (Melendez et al., 1995) rosophila inhibitor of apoptosis protein (Garcia-Lopez et al., 2008) thread (Garcia-Lopez et al., 2008, Hoopfer et al., 2008, Cordero and Cagan, 2010, Guan et al., 2007, Mislak et al., 2007, Moreno et al., 2002, Gregory et al., 2007, Shapiro and Ryoo, 2008, Liu and Lehmann, 2008, Sathyanarayanan et al., 2008, Chandraratna et al., 2007, Takahashi and Ting, 2004, Oh and Irvine, 2008, Cho et al., 2006, Martín et al., 2009, Branco et al., 2008, Lai et al., 2007, Morris et al., 2006, Bardet et al., 2008, Milton et al., 2010, Arya et al., 2010, Terashima and Bownes, 2005, Rauskolb et al., 2011) Thread (Liu et al., 2009)
Secondary FlyBase IDs
	FBgn0003691 FBgn0011383 FBgn0015246 FBgn0016903 FBgn0046835 FBgn0046836
References ( 554 )
Generate a list of	All references relating to this gene ( 554 )
List References by type	Research paper  ( 363 ) Supplementary material  ( 21 ) Review  ( 78 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 63 ) FlyBase analysis  ( 2 ) Conference report  ( 5 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 5 ) Protein sequence record  ( 1 ) Book  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 55 )
	Cooper and Kennison, 2011, PLoS ONE 6(8): e23509 Molecular Genetic Analyses of Polytene Chromosome Region 72A-D in Drosophila melanogaster Reveal a Gene Desert in 72D. [FBrf0214748] Fernández et al., 2011, Development 138(11): 2337--2346 Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila. [FBrf0213674] Gilbert et al., 2011, Dev. Cell 20(5): 700--712 A Screen for Conditional Growth Suppressor Genes Identifies the Drosophila Homolog of HD-PTP as a Regulator of the Oncoprotein Yorkie. [FBrf0213686] Lee et al., 2011, PLoS Genet. 7(9): e1002261 Drosophila IAP1-Mediated Ubiquitylation Controls Activation of the Initiator Caspase DRONC Independent of Protein Degradation. [FBrf0215256] Li et al., 2011, Nat. Commun. 2: 408 Structural mechanisms of DIAP1 auto-inhibition and DIAP1-mediated inhibition of drICE. [FBrf0214630] Otani et al., 2011, Dev. Cell 20(2): 219--232 IKKɛ Regulates Cell Elongation through Recycling Endosome Shuttling. [FBrf0212985] Rauskolb et al., 2011, PLoS Biol. 9(6): e1000624 Zyxin links fat signaling to the hippo pathway. [FBrf0213900] Resnik-Docampo and de Celis, 2011, PLoS ONE 6(1): e14528 MAP4K3 Is a Component of the TORC1 Signalling Complex that Modulates Cell Growth and Viability in Drosophila melanogaster. [FBrf0212911] Richter et al., 2011, Nat. Cell Biol. 13(9): 1029--1039 The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements. [FBrf0215050] Sansores-Garcia et al., 2011, EMBO J. 30(12): 2325--2335 Modulating F-actin organization induces organ growth by affecting the Hippo pathway. [FBrf0213953] Shukla and Tapadia, 2011, Europ. J. Cell Biol. 90(1): 72--80 Differential localization and processing of apoptotic proteins in Malpighian tubules of Drosophila during metamorphosis. [FBrf0212365] Suissa et al., 2011, J. Biol. Chem. 286(17): 15556--15564 The NAB-Brk Signal Bifurcates at JNK to Independently Induce Apoptosis and Compensatory Proliferation. [FBrf0213516] Tanner et al., 2011, Development 138(2): 327--338 Bcl-2 proteins and autophagy regulate mitochondrial dynamics during programmed cell death in the Drosophila ovary. [FBrf0212552] Tao and Rolls, 2011, J. Neurosci. 31(14): 5398--5405 Dendrites have a rapid program of injury-induced degeneration that is molecularly distinct from developmental pruning. [FBrf0213404] Vandergaast et al., 2011, J. Virol. 85(16): 8348--8358 Active Depletion of Host Cell Inhibitor-of-Apoptosis Proteins Triggers Apoptosis upon Baculovirus DNA Replication. [FBrf0214468] Yan et al., 2011, Development 138(9): 1697--1703 Drosophila PI4KIIIalpha is required in follicle cells for oocyte polarization and Hippo signaling. [FBrf0213488] Ying et al., 2011, PLoS ONE 6(9): e23863 Comprehensively Surveying Structure and Function of RING Domains from Drosophila melanogaster. [FBrf0215242] Arya et al., 2010, Ann. Neurosci. 17(1): 8--17 Hsp60D - A novel modifier of polyglutamine-mediated neuro degeneration in Drosophila. [FBrf0211649] Bader et al., 2010, Development 137(10): 1679--1688 A novel F-box protein is required for caspase activation during cellular remodeling in Drosophila. [FBrf0210629] Bakhrat et al., 2010, Apoptosis 15(12): 1425--1434 Drosophila Chk2 and p53 proteins induce stage-specific cell death independently during oogenesis. [FBrf0212376] Baumgartner et al., 2010, Dev. Cell 18(2): 309--316 The WW Domain Protein Kibra Acts Upstream of Hippo in Drosophila. [FBrf0210061] Bejarano et al., 2010, Dev. Biol. 338(1): 63--73 miR-9a prevents apoptosis during wing development by repressing Drosophila LIM-only. [FBrf0209786] Benitez et al., 2010, Int. J. Dev. Biol. 54(4): 643--653 Both jnk and apoptosis pathways regulate growth and terminalia rotation during Drosophila genital disc development. [FBrf0210146] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Broemer et al., 2010, Mol. Cell 40(5): 810--822 Systematic In Vivo RNAi Analysis Identifies IAPs as NEDD8-E3 Ligases. [FBrf0212528] Chen et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(36): 15810--15815 The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila. [FBrf0211766] Cordero and Cagan, 2010, Dev. Dyn. 239(3): 875--884 Canonical wingless signaling regulates cone cell specification in the Drosophila retina. [FBrf0210104] Cully et al., 2010, Mol. Cell. Biol. 30(2): 481--495 A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1. [FBrf0209636] Das Thakur et al., 2010, Curr. Biol. 20(7): 657--662 Ajuba LIM proteins are negative regulators of the Hippo signaling pathway. [FBrf0210592] Froldi et al., 2010, BMC Biol. 8: 33 The lethal giant larvae tumour suppressor mutation requires dMyc oncoprotein to promote clonal malignancy. [FBrf0210873] Genevet et al., 2010, Dev. Cell 18(2): 300--308 Kibra is a regulator of the Salvador/Warts/Hippo signaling network. [FBrf0211094] Grzeschik et al., 2010, Curr. Biol. 20(7): 573--581 Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms. [FBrf0210559] Hilgers et al., 2010, PLoS Biol. 8(6): e1000396 Drosophila microRNAs 263a/b Confer Robustness during Development by Protecting Nascent Sense Organs from Apoptosis. [FBrf0211074] Kim et al., 2010, BMC Cell Biol. 11: 9 A genetic screen for modifiers of Drosophila caspase Dcp-1 reveals caspase involvement in autophagy and novel caspase-related genes. [FBrf0209948] Ling et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(23): 10532--10537 The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded. [FBrf0211036] Liu et al., 2010, J. Neurosci. 30(35): 11624--11634 Distinct Presynaptic and Postsynaptic Dismantling Processes of Drosophila Neuromuscular Junctions during Metamorphosis. [FBrf0211694] Malzer et al., 2010, J. Cell Sci. 123(17): 2892--2900 Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response. [FBrf0211608] Matova and Anderson, 2010, J. Cell Sci. 123(4): 627--633 Drosophila Rel proteins are central regulators of a robust, multi-organ immune network. [FBrf0209910] Menéndez et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(33): 14651--14656 A tumor-suppressing mechanism in Drosophila involving cell competition and the Hippo pathway. [FBrf0211593] Mesquita et al., 2010, PLoS Biol. 8(12): e1000566 A dp53-Dependent Mechanism Involved in Coordinating Tissue Growth in Drosophila. [FBrf0212630] Milton et al., 2010, Development 137(5): 735--743 Differential requirement of Salvador-Warts-Hippo pathway members for organ size control in Drosophila melanogaster. [FBrf0209966] Neisch et al., 2010, J. Cell Biol. 189(2): 311--323 Rho1 regulates apoptosis via activation of the JNK signaling pathway at the plasma membrane. [FBrf0210554] Neto-Silva et al., 2010, Dev. Cell 19(4): 507--520 Evidence for a Growth-Stabilizing Regulatory Feedback Mechanism between Myc and Yorkie, the Drosophila Homolog of Yap. [FBrf0212043] Nezis et al., 2010, J. Cell Biol. 190(4): 523--531 Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late Drosophila melanogaster oogenesis. [FBrf0211647] Nicolay et al., 2010, PLoS Genet. 6(4): e1000918 Combined inactivation of pRB and hippo pathways induces dedifferentiation in the Drosophila retina. [FBrf0210644] Reddy et al., 2010, Development 137(14): 2397--2408 Influence of fat-hippo and notch signaling on the proliferation and differentiation of Drosophila optic neuroepithelia. [FBrf0211109] Rhiner et al., 2010, Dev. Cell 18(6): 985--998 Flower forms an extracellular code that reveals the fitness of a cell to its neighbors in Drosophila. [FBrf0211273] Robinson et al., 2010, Curr. Biol. 20(7): 582--590 Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein expanded. [FBrf0210560] Sandu et al., 2010, J. Cell Biol. 190(6): 1039--1052 Drosophila IAP antagonists form multimeric complexes to promote cell death. [FBrf0211820] Sekyrova et al., 2010, Development 137(1): 141--150 Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis. [FBrf0209550] Suzanne et al., 2010, Curr. Biol. 20(19): 1773--1778 Coupling of apoptosis and L/R patterning controls stepwise organ looping. 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