FlyBase Gene Report: Dmel\CG42537

General Information

Symbol

Dmel\CG42537

Species

D. melanogaster

Name

Annotation Symbol

CG42537

Feature Type

protein_coding_gene

FlyBase ID

FBgn0260645

Gene Model Status

Current

Stock Availability

2 publicly available

Gene Snapshot

Contributions welcome

Other Summaries

Alliance
Auto summary
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

Sequence location

3R:6,377,797..6,378,233 [+]

Recombination map

3-47.5

RefSeq locus

NT_033777 REGION:6377797..6378233

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (1 term)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables serine-type endopeptidase inhibitor activity

inferred from electronic annotation with InterPro:IPR002223

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CG42537 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene

nuclear_gene

(FlyBase Genome Annotators, 2009, Christensen et al., 2008.4.15)

protein_coding_gene

(FlyBase Genome Annotators, 2009, Christensen et al., 2008.4.15)

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CG42537-RA

FBtr0301001

NM_001170059

376

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

CG42537-PA

FBpp0290223

10.3

9.67

NP_001163530

ACZ94828

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

E1JJ70

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG42537 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG42537_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG42537 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG42537

View exonic expression by tissue for Dmel\CG42537

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0260645

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10284

Flygut - An atlas of the Drosophila adult midgut

FBgn0260645

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 2 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG42537

Transgenic constructs containing regulatory region of CG42537

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation

Inferred from location

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (14)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\CLEC18A

2 of 15

Yes

Hsap\CLEC18B

2 of 15

Yes

Hsap\CRISP1

2 of 15

Yes

Hsap\CRISP2

2 of 15

Yes

Hsap\CRISPLD1

2 of 15

Yes

Hsap\CRISPLD2

2 of 15

Yes

Hsap\GLIPR1

2 of 15

Yes

Hsap\GLIPR1L1

2 of 15

Yes

Hsap\GLIPR1L2

2 of 15

Yes

Hsap\GLIPR2

2 of 15

Yes

Hsap\PI15

2 of 15

Yes

Hsap\PI16

2 of 15

Yes

Hsap\R3HDML

2 of 15

Yes

Hsap\CRISP3

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (15)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Clec18a

2 of 15

Yes

Mmus\Crisp1

2 of 15

Yes

Mmus\Crisp2

2 of 15

Yes

Mmus\Crisp3

2 of 15

Yes

Mmus\Crispld1

2 of 15

Yes

Mmus\Crispld2

2 of 15

Yes

Mmus\Glipr1l1

2 of 15

Yes

Mmus\Glipr1l2

2 of 15

Yes

Mmus\Glipr2

2 of 15

Yes

Mmus\Pi15

2 of 15

Yes

Mmus\Pi16

2 of 15

Yes

Mmus\R3hdml

2 of 15

Yes

Mmus\Crisp4

1 of 15

Mmus\Glipr1l3

1 of 15

Mmus\Glipr1

1 of 15

Rattus norvegicus (Norway rat) (13)

Rnor\Crisp1

2 of 13

Yes

Rnor\Crisp2

2 of 13

Yes

Rnor\Crisp3

2 of 13

Yes

Rnor\Crispld1

2 of 13

Yes

Rnor\Crispld2

2 of 13

Yes

Rnor\Glipr1l1

2 of 13

Yes

Rnor\Glipr1l2

2 of 13

Yes

Rnor\Glipr1

2 of 13

Yes

Rnor\Glipr2

2 of 13

Yes

Rnor\Pi15

2 of 13

Yes

Rnor\Pi16

2 of 13

Yes

Rnor\R3hdml

2 of 13

Yes

Rnor\Clec18a

1 of 13

Xenopus tropicalis (Western clawed frog) (17)

Xtro\crisp1

2 of 12

Yes

Xtro\crisp2

2 of 12

Yes

Xtro\crisp3

2 of 12

Yes

Xtro\crispld2

2 of 12

Yes

Xtro\glipr2

2 of 12

Yes

Xtro\MGC108118

2 of 12

Yes

Xtro\r3hdml

2 of 12

Yes

Xtro\crisp2-like

1 of 12

Xtro\crispld1

1 of 12

Xtro\LOC100127722

1 of 12

Yes

Xtro\LOC100490275

1 of 12

Yes

Xtro\LOC100492430

1 of 12

Yes

Xtro\LOC100497187

1 of 12

Xtro\LOC101732829

1 of 12

Yes

Xtro\LOC105947480

1 of 12

Yes

Xtro\pi15

1 of 12

Xtro\pi16

1 of 12

Yes

Danio rerio (Zebrafish) (13)

Drer\crispld1a

2 of 15

Yes

Drer\crispld1b

2 of 15

Yes

Drer\crispld2

2 of 15

Yes

Drer\glipr1b

2 of 15

Yes

Drer\glipr2

2 of 15

Yes

Drer\glipr2l

2 of 15

Yes

Drer\LOC100536500

2 of 15

Yes

Drer\pi15a

2 of 15

Yes

Drer\pi15b

2 of 15

Yes

Drer\r3hdml

2 of 15

Yes

Drer\glipr1a

1 of 15

Drer\im:7150988

1 of 15

Drer\LOC101883528

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (36)

Cele\C07A4.2

2 of 15

Yes

Cele\C07A4.3

2 of 15

Yes

Cele\D2062.1

2 of 15

Yes

Cele\F09B9.5

2 of 15

Yes

Cele\F57B7.2

2 of 15

Yes

Cele\F58E2.5

2 of 15

Yes

Cele\lon-1

2 of 15

Yes

Cele\scl-1

2 of 15

Yes

Cele\scl-2

2 of 15

Yes

Cele\scl-3

2 of 15

Yes

Cele\scl-5

2 of 15

Yes

Cele\scl-6

2 of 15

Yes

Cele\scl-7

2 of 15

Yes

Cele\scl-8

2 of 15

Yes

Cele\scl-9

2 of 15

Yes

Cele\scl-10

2 of 15

Yes

Cele\scl-11

2 of 15

Yes

Cele\scl-12

2 of 15

Yes

Cele\scl-13

2 of 15

Yes

Cele\scl-14

2 of 15

Yes

Cele\scl-15

2 of 15

Yes

Cele\scl-17

2 of 15

Yes

Cele\scl-18

2 of 15

Yes

Cele\scl-19

2 of 15

Yes

Cele\scl-20

2 of 15

Yes

Cele\scl-21

2 of 15

Yes

Cele\scl-23

2 of 15

Yes

Cele\scl-24

2 of 15

Yes

Cele\scl-25

2 of 15

Yes

Cele\scl-26

2 of 15

Yes

Cele\scl-27

2 of 15

Yes

Cele\vap-1

2 of 15

Yes

Cele\vap-2

2 of 15

Yes

Cele\clec-75

1 of 15

Yes

Cele\T12A7.10

1 of 15

Yes

Cele\Y39G8B.10

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (22)

Atha\AT1G01310

1 of 9

Yes

Atha\AT1G50050

1 of 9

Yes

Atha\AT1G50060

1 of 9

Yes

Atha\AT2G19970

1 of 9

Yes

Atha\AT2G19980

1 of 9

Yes

Atha\AT3G09590

1 of 9

Yes

Atha\AT3G19690

1 of 9

Yes

Atha\AT4G07820

1 of 9

Yes

Atha\AT4G25780

1 of 9

Yes

Atha\AT4G25790

1 of 9

Yes

Atha\AT4G30320

1 of 9

Yes

Atha\AT4G31470

1 of 9

Yes

Atha\AT4G33710

1 of 9

Yes

Atha\AT4G33720

1 of 9

Yes

Atha\AT4G33730

1 of 9

Yes

Atha\AT5G02730

1 of 9

Yes

Atha\AT5G26130

1 of 9

Yes

Atha\AT5G57625

1 of 9

Yes

Atha\AT5G66590

1 of 9

Yes

Atha\PR1

1 of 9

Yes

Atha\PR-1-LIKE

1 of 9

Yes

Atha\PRB1

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (3)

Scer\PRY1

1 of 15

Yes

Scer\PRY2

1 of 15

Yes

Scer\PRY3

1 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190KHR )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00008080

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00008076

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00011085

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila erecta

Drosophila yakuba

Drosophila yakuba

Drosophila yakuba

Drosophila ananassae

Drosophila ananassae

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA28564

Drosophila pseudoobscura pseudoobscura

Dpse\GA30713

Drosophila persimilis

Dper\GL20811

Drosophila persimilis

Dper\GL22203

Drosophila willistoni

Dwil\GK23982

Drosophila willistoni

Drosophila virilis

Drosophila virilis

Drosophila virilis

Drosophila virilis

Drosophila virilis

Drosophila virilis

Drosophila mojavensis

Dmoj\GI16654

Drosophila mojavensis

Drosophila grimshawi

Drosophila grimshawi

Drosophila grimshawi

Drosophila grimshawi

Drosophila grimshawi

Drosophila grimshawi

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150IDF )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17021675

Musca domestica

House fly

Mdoa\17014153

Musca domestica

House fly

Mdoa\17021674

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_12132

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_12145

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_12853

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_12129

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_07325

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_06552

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_12144

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_12141

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_07128

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_12133

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_12131

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_12146

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_06553

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )

No non-Dipteran orthologies identified

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0OJ8 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Ixodes scapularis

Black-legged tick

Isca\ISCW024441

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )

No non-Arthropod Metazoa orthologies identified

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (37)

Gene Symbol

Score

Source

Alignment

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0260645

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-47.5

Cytogenetic map

83E5-83E5

Sequence location

3R:6,377,797..6,378,233 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

83E5-83E5

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-47.5

(FlyBase, 2016)

3-44.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (2)

Bloomington

77277

y¹ sc^* v¹ sev²¹; P{TKO.GS01114}attP40

79428

y¹ sc^* v¹ sev²¹; P{TOE.GS01189}attP40/CyO

Genomic Clones (16)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (7)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0260645

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

8674074

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Additional comments

The 3' exon of annotation CG10284 was deleted from the annotation in release 5.1 of the genome annotation. This exon has been restored as part of a separate annotation, called CG42537, in release 5.15 of the genome annotation. In addition, the CG10284 annotation has been renamed CG42564 in release 5.15 of the genome annotation to avoid confusion.

(Christensen et al., 2008.4.15)

Other Comments

New annotation (CG42537) in release 5.15 of the genome annotation.

(FlyBase Genome Annotators, 2009)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 17 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

8674074

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

ACZ94828

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

E1JJ70

Other crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG42537_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10284

Flygut - An atlas of the Drosophila adult midgut

FBgn0260645

FlyMine - An integrated database for Drosophila genomics

FBgn0260645

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

8674074

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG42537

modMine - A data warehouse for the modENCODE project

FBgn0260645

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0260645

DRSC - Results frm RNAi screens

FBgn0260645

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0260645

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

BRG-A3

(Kress et al., 2004)

CG10284

(Swanson et al., 2001)

CG42537

(Transgenic RNAi Project members, 2017-, Laflamme and Wolfner, 2013, FlyBase Genome Annotators, 2011, The modENCODE Consortium, 2010, FlyBase Genome Annotators, 2009, Christensen et al., 2008.4.15)

Name Synonyms

Secondary FlyBase IDs

FBgn0037441

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (13)

The following external sites may use different assemblies or annotations than FlyBase.

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