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Gene Dmel\mp

General Information
Symbol	Dmel\mp	Species	D. melanogaster
Name	multiplexin	Annotation symbol	CG42543
Feature type	protein_coding_gene	FlyBase ID	FBgn0260660
Gene Model Status	Current	Stock availability	13 publicly available
Also Known As	CG33171, CG8647
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	65E1-65E2	Sequence location	3L:6,991,943..7,046,528 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene multiplexin is referred to in FlyBase by the symbol Dmel\mp (CG42543, FBgn0260660). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: binding; structural molecule activity. There is experimental evidence that it is involved in the biological process: motor axon guidance. 16 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; lipid particle; intersegmental nerve; mesothoracic tergum; embryonic/larval fat body; ISNb; presumptive embryonic/larval nervous system; chordotonal organ; tergite; wing vein. It has 13 annotated transcripts and 13 annotated polypeptides. Protein features are: C-type lectin fold; C-type lectin-like; Collagen triple helix repeat; Collagenase NC10/endostatin; Concanavalin A-like lectin/glucanase; Laminin G, thrombospondin-type, N-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval central nervous system, larval hindgut, adult heart, larval trachea, adult testis, larval carcass. Gene sequence location is 3L:6991943..7046528.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Controlled Vocabulary Terms day 42 of adulthood day 41 of adulthood day 30 of adulthood day 49 of adulthood day 17 of adulthood day 45 of adulthood day 8 of adulthood day 26 of adulthood day 21 of adulthood day 13 of adulthood day 25 of adulthood day 20 of adulthood day 22 of adulthood day 39 of adulthood day 7 of adulthood day 36 of adulthood day 11 of adulthood day 37 of adulthood day 27 of adulthood day 18 of adulthood day 19 of adulthood day 28 of adulthood day 9 of adulthood day 29 of adulthood adult heart day 40 of adulthood day 16 of adulthood day 24 of adulthood day 15 of adulthood day 33 of adulthood day 43 of adulthood day 47 of adulthood day 38 of adulthood day 32 of adulthood day 48 of adulthood day 23 of adulthood day 35 of adulthood day 12 of adulthood day 10 of adulthood day 31 of adulthood day 34 of adulthood day 44 of adulthood day 14 of adulthood day 46 of adulthood
FB2012_01	Sequence features HFA11029 HFA10193 HFA11030 BKN23905 BKN28613
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 65E1-65E2   Limits computationally determined from genome sequence between P{lacW}l(3)L4060L4060 and P{PZ}corn04202
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\mp for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	merge of CG33171 and CG8647 Gene model reviewed during 5.41 Gene merge based on EST/cDNA data.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) mp-RB FBtr0301105  NM_001169885   3906   1008 mp-RE FBtr0301106  NM_176293   4140   778 mp-RF FBtr0301107  NM_001169886   4167   787 mp-RG FBtr0301108  NM_001169887   3956   1023 mp-RH FBtr0301109  NM_001169888   4245   813 mp-RI FBtr0301110  NM_001169889   2577   257 mp-RJ FBtr0301111  NM_001169890   3103   579 mp-RL FBtr0301113  NM_001169892   3800   971 mp-RM FBtr0301114  NM_001169893   3938   1017 mp-RN FBtr0301958  NM_176294   5055   792 mp-RO FBtr0306638     3901   1013 mp-RP FBtr0308094     1145   229 mp-RR FBtr0309957     3974   1039
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein mp-PB   FBpp0290327   106.1   1008   5.71     NP_001163356   ACZ94627 mp-PE   FBpp0290328   80.8   778   8.68     NP_788471   AAO41273 mp-PF   FBpp0290329   81.9   787   8.33     NP_001163357   ACZ94628 mp-PG   FBpp0290330   108.1   1023   6.03     NP_001163358   ACZ94629 mp-PH   FBpp0290331   84.7   813   6.64     NP_001163359   ACZ94630 mp-PI   FBpp0290332   28.6   257   9.84     NP_001163360   ACZ94631 mp-PJ   FBpp0290333   60.3   579   8.02     NP_001163361   ACZ94632 mp-PL   FBpp0290335   102.0   971   5.51     NP_001163363   ACZ94634 mp-PM   FBpp0290336   107.1   1017   5.52     NP_001163364   ACZ94635 mp-PN   FBpp0291170   82.6   792   8.50     NP_788472   AAO41274 mp-PO   FBpp0297593   106.8   1013   5.82       mp-PP   FBpp0300437   25.6   229   8.93       mp-PR   FBpp0301686   109.7   1039   5.72
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Collagen triple helix repeat (IPR008160) Collagenase NC10/endostatin (IPR010515) C-type lectin-like (IPR016186) C-type lectin fold (IPR016187) Laminin G, thrombospondin-type, N-terminal (IPR003129) Concanavalin A-like lectin/glucanase (IPR008985)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAO41273   AE014296 AAO41274   AE014296 ACZ94627   AE014296 ACZ94628   AE014296 ACZ94629   AE014296 ACZ94630   AE014296 ACZ94631   AE014296 ACZ94632   AE014296 ACZ94634   AE014296 ACZ94635   AI238354   AI388481   AI403342   AY118310 AAM48339   AY118874 AAM50734   BG633060   BI234219   BI234499   BI355320   BI569130   BI569131   BI569291   BI569292   BI570313   BI589670   BI589671   BI589726   BT099880   BT120165   BT124741   CO187198   CO262364   CO273475   CO282091   CO288077   CO293984   CO297819   CO301245   CO306493   CO324862   CO326368   CO326661   CO329275   CO341478   CO343910   CO345113   CZ485566   CZ490064   CZ490065   EC086319   EC088784   EC091113   EC199544   EC203131   EC206465   EC207977   EC234682   EC239308   EC246022   EC251750   EC252188   EC258636   EC260121   GH942717   GH943328   GH964576
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q86BH1 Q8MSE3 Q8MT89 E1JI51 E1JI52 E1JI49 E1JI50 E1JIE2 E1JIE1 E1JID9 E1JIE0 E1JIE3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0260660    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0260660 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0260660 expression level Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    3 embryo 04-06hr    3 embryo 06-08hr    8 embryo 08-10hr    16 embryo 10-12hr    46 embryo 12-14hr    117 embryo 14-16hr    639 embryo 16-18hr    1597 embryo 18-20hr    1904 embryo 20-22hr    1143 embryo 22-24hr    1104 larva L1    1186 larva L2    462 larva L3 12hr old    499 larva L3 puffstage 1-2    205 larva L3 puffstage 3-6    478 larva L3 puffstage 7-9    815 white prepupae new    1340 white prepupae 12hr    1980 white prepupae 24hr    1351 pupae 2d postWPP    1635 pupae 3d postWPP    1528 pupae 4d postWPP    919 adult male 01day    662 adult male 05day    400 adult male 30day    422 adult female 01day    512 adult female 05day    163 adult female 30day    165 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    3 embryo 04-06hr    3 embryo 06-08hr    8 embryo 08-10hr    16 embryo 10-12hr    46 embryo 12-14hr  (117) embryo 14-16hr  (639) embryo 16-18hr  (1597) embryo 18-20hr  (1904) embryo 20-22hr  (1143) embryo 22-24hr  (1104) larva L1  (1186) larva L2  (462) larva L3 12hr old  (499) larva L3 puffstage 1-2  (205) larva L3 puffstage 3-6  (478) larva L3 puffstage 7-9  (815) white prepupae new  (1340) white prepupae 12hr  (1980) white prepupae 24hr  (1351) pupae 2d postWPP  (1635) pupae 3d postWPP  (1528) pupae 4d postWPP  (919) adult male 01day  (662) adult male 05day  (400) adult male 30day  (422) adult female 01day  (512) adult female 05day  (163) adult female 30day  (165) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    3 embryo 04-06hr    3 embryo 06-08hr    8 embryo 08-10hr    16 embryo 10-12hr    46 embryo 12-14hr    117 embryo 14-16hr    639 embryo 16-18hr  (1597) embryo 18-20hr  (1904) embryo 20-22hr    1143 embryo 22-24hr    1104 larva L1    1186 larva L2    462 larva L3 12hr old    499 larva L3 puffstage 1-2    205 larva L3 puffstage 3-6    478 larva L3 puffstage 7-9    815 white prepupae new    1340 white prepupae 12hr  (1980) white prepupae 24hr    1351 pupae 2d postWPP  (1635) pupae 3d postWPP  (1528) pupae 4d postWPP    919 adult male 01day    662 adult male 05day    400 adult male 30day    422 adult female 01day    512 adult female 05day    163 adult female 30day    165 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    3 embryo 04-06hr    3 embryo 06-08hr    8 embryo 08-10hr    16 embryo 10-12hr    46 embryo 12-14hr    117 embryo 14-16hr    639 embryo 16-18hr    1597 embryo 18-20hr    1904 embryo 20-22hr    1143 embryo 22-24hr    1104 larva L1    1186 larva L2    462 larva L3 12hr old    499 larva L3 puffstage 1-2    205 larva L3 puffstage 3-6    478 larva L3 puffstage 7-9    815 white prepupae new    1340 white prepupae 12hr    1980 white prepupae 24hr    1351 pupae 2d postWPP    1635 pupae 3d postWPP    1528 pupae 4d postWPP    919 adult male 01day    662 adult male 05day    400 adult male 30day    422 adult female 01day    512 adult female 05day    163 adult female 30day    165 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    3 embryo 04-06hr    3 embryo 06-08hr    8 embryo 08-10hr    16 embryo 10-12hr    46 embryo 12-14hr    117 embryo 14-16hr    639 embryo 16-18hr    1597 embryo 18-20hr    1904 embryo 20-22hr    1143 embryo 22-24hr    1104 larva L1    1186 larva L2    462 larva L3 12hr old    499 larva L3 puffstage 1-2    205 larva L3 puffstage 3-6    478 larva L3 puffstage 7-9    815 white prepupae new    1340 white prepupae 12hr    1980 white prepupae 24hr    1351 pupae 2d postWPP    1635 pupae 3d postWPP    1528 pupae 4d postWPP    919 adult male 01day    662 adult male 05day    400 adult male 30day    422 adult female 01day    512 adult female 05day    163 adult female 30day    165 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0260660 expression level Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    3 embryo 04-06hr    3 embryo 06-08hr    8 embryo 08-10hr    16 embryo 10-12hr    46 embryo 12-14hr    117 embryo 14-16hr    639 embryo 16-18hr    1597 embryo 18-20hr    1904 embryo 20-22hr    1143 embryo 22-24hr    1104 larva L1    1186 larva L2    462 larva L3 12hr old    499 larva L3 puffstage 1-2    205 larva L3 puffstage 3-6    478 larva L3 puffstage 7-9    815 white prepupae new    1340 white prepupae 12hr    1980 white prepupae 24hr    1351 pupae 2d postWPP    1635 pupae 3d postWPP    1528 pupae 4d postWPP    919 adult male 01day    662 adult male 05day    400 adult male 30day    422 adult female 01day    512 adult female 05day    163 adult female 30day    165 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    3 embryo 04-06hr    3 embryo 06-08hr    8 embryo 08-10hr    16 embryo 10-12hr    46 embryo 12-14hr  117 embryo 14-16hr  (639) embryo 16-18hr  (1597) embryo 18-20hr  (1904) embryo 20-22hr  (1143) embryo 22-24hr  (1104) larva L1  (1186) larva L2  (462) larva L3 12hr old  (499) larva L3 puffstage 1-2  (205) larva L3 puffstage 3-6  (478) larva L3 puffstage 7-9  (815) white prepupae new  (1340) white prepupae 12hr  (1980) white prepupae 24hr  (1351) pupae 2d postWPP  (1635) pupae 3d postWPP  (1528) pupae 4d postWPP  (919) adult male 01day  (662) adult male 05day  (400) adult male 30day  (422) adult female 01day  (512) adult female 05day  (163) adult female 30day  (165) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    3 embryo 04-06hr    3 embryo 06-08hr    8 embryo 08-10hr    16 embryo 10-12hr    46 embryo 12-14hr    117 embryo 14-16hr    639 embryo 16-18hr  1597 embryo 18-20hr  1904 embryo 20-22hr    1143 embryo 22-24hr    1104 larva L1    1186 larva L2    462 larva L3 12hr old    499 larva L3 puffstage 1-2    205 larva L3 puffstage 3-6    478 larva L3 puffstage 7-9    815 white prepupae new    1340 white prepupae 12hr  1980 white prepupae 24hr    1351 pupae 2d postWPP  1635 pupae 3d postWPP  1528 pupae 4d postWPP    919 adult male 01day    662 adult male 05day    400 adult male 30day    422 adult female 01day    512 adult female 05day    163 adult female 30day    165 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    3 embryo 04-06hr    3 embryo 06-08hr    8 embryo 08-10hr    16 embryo 10-12hr    46 embryo 12-14hr    117 embryo 14-16hr    639 embryo 16-18hr    1597 embryo 18-20hr    1904 embryo 20-22hr    1143 embryo 22-24hr    1104 larva L1    1186 larva L2    462 larva L3 12hr old    499 larva L3 puffstage 1-2    205 larva L3 puffstage 3-6    478 larva L3 puffstage 7-9    815 white prepupae new    1340 white prepupae 12hr    1980 white prepupae 24hr    1351 pupae 2d postWPP    1635 pupae 3d postWPP    1528 pupae 4d postWPP    919 adult male 01day    662 adult male 05day    400 adult male 30day    422 adult female 01day    512 adult female 05day    163 adult female 30day    165 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    3 embryo 04-06hr    3 embryo 06-08hr    8 embryo 08-10hr    16 embryo 10-12hr    46 embryo 12-14hr    117 embryo 14-16hr    639 embryo 16-18hr    1597 embryo 18-20hr    1904 embryo 20-22hr    1143 embryo 22-24hr    1104 larva L1    1186 larva L2    462 larva L3 12hr old    499 larva L3 puffstage 1-2    205 larva L3 puffstage 3-6    478 larva L3 puffstage 7-9    815 white prepupae new    1340 white prepupae 12hr    1980 white prepupae 24hr    1351 pupae 2d postWPP    1635 pupae 3d postWPP    1528 pupae 4d postWPP    919 adult male 01day    662 adult male 05day    400 adult male 30day    422 adult female 01day    512 adult female 05day    163 adult female 30day    165 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0260660    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0260660 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval central nervous system, larval hindgut, adult heart, larval trachea, adult testis, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut     Adult Hindgut no informative data Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland     Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland     Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_18
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0260660
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable mpf03008 mpf07253 mpΔC12-25 mpΔN4-11 viable, with Scer\GAL4pnr-MD237 mpGD6041 mpGD12529 Sterility Allele fertile mpf03008 mpf07253 Other Phenotypes Allele body color defective, with Scer\GAL4pnr-MD237 mpGD6041 developmental rate defective mpΔC12-25 mpΔN4-11 neuroanatomy defective | embryonic stage mpΔC12-25 mpΔN4-11 neuroanatomy defective | embryonic stage, with Scer\GAL4how-24B mpES.Scer\UAS.T:wg touch sensitivity defective | larval stage mpf03008 mpf07253 visible mpf07253 visible, with Scer\GAL4pnr-MD237 mpGD6041 visible (with mpf03008) mpf07253 visible (with mpf07253) mpf03008 Phenotype manifest in Allele chordotonal organ mpf07253 embryonic/larval fat body mpf03008 mpf07253 intersegmental nerve, with Scer\GAL4how-24B mpES.Scer\UAS.T:wg ISNb mpΔN4-11 mpΔC12-25 ISNb, with Scer\GAL4how-24B mpES.Scer\UAS.T:wg lipid particle mpf03008 mpf07253 mesothoracic tergum, with Scer\GAL4pnr-MD237 mpGD6041 presumptive embryonic/larval nervous system, with Scer\GAL4how-24B mpES.Scer\UAS.T:wg tergite mpf03008 mpf07253 tergite (with mpf03008) mpf07253 tergite (with mpf07253) mpf03008 trichogen cell, with Scer\GAL4pnr-MD237 mpGD6041 wing vein mpf07253 wing vein (with mpf03008) mpf07253 wing vein (with mpf07253) mpf03008
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of mp Class Mutagen Stocks Known lesion mpf07253 piggyBac transposase 2 -- mpc01251 1 -- mpDG37705 P-element activity 1 -- mpf03008 piggyBac transposase 1 -- mpMB01109 1 -- mpMB08228 1 -- mpΔC12-25 FLPase 0 Yes mpΔN4-11 FLPase 0 Yes
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mp Class Mutagen Stocks Known lesion mpGD6041 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes mpGD12529 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mpJF02929 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mpKK103713 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mpKK108613 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mp3hNC1.Scer\UAS in vitro construct - regulatory fusion 0 Yes mpES.Scer\UAS.T:wg in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes mpNC1.Scer\UAS.T:wg in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK103713} NA P{KK108613} NA P{TRiP.JF02929} NA P{UAS-mp.3hNC1} NA P{UAS-mp.ES} NA P{UAS-mp.NC1} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{wHy}mpDG37705 NA PBac{PB3.WH3}mpΔC12-25 NA PBac{PB}mpc01251 NA PBac{WH}mpf03008 NA PBac{WH}mpf07253 NA insertion of enhancer trap binary system Mi{ET1}mpMB01109 No Mi{ET1}mpMB08228 No insertion of mobile activating element PBac{WHr}mpΔN4-11 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
motor axon guidance inferred from mutant phenotype (Meyer and Moussian, 2009)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
binding inferred from electronic annotation with InterPro:IPR016186, InterPro:IPR016187 (FlyBase Curators et al., 2004-) structural molecule activity inferred from electronic annotation with InterPro:IPR003129, InterPro:IPR010515 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
cell adhesion inferred from electronic annotation with InterPro:IPR003129, InterPro:IPR010515 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
collagen inferred from sequence or structural similarity (Hynes and Zhao, 2000) extracellular matrix inferred from electronic annotation with InterPro:IPR010515 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mp allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0260660 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38769
Orthologs
Genome-wide drosophilid orthologs	Dana\GF25003 Dana\GF25004 Dere\GG14398 Dere\GG14399 Dgri\GH15384 Dgri\GH15385 Dmoj\GI12989 Dmoj\GI12990 Dper\GL25019 Dper\GL25020 Dpse\GA21236 Dpse\GA23588 Dsec\GM14812 Dsec\GM14813 Dsim\GD13984 Dsim\GD13988 Dvir\GJ13131 Dvir\GJ13132 Dwil\GK16645 Dwil\GK16646 Dyak\GE21587 Dyak\GE21588
Curated drosophilid orthologs	Dpse\GA17340   Dpse\GA21236
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV16687 LH20456 FBgn0238843 FBgn0218648 FBgn0200359 FBgn0185684 FBgn0169734 JGI_V11_48387 JGI_V11_48458 JGI_V11_15160 FBgn0244988 FBgn0162607 FBgn0135747 FBgn0122857 FBgn0106658 FBgn0101996 CPIJ005619 BGIBMGA012062 ACYPI49091 GB18123 AGAP006516 AAEL002256 PB23441 PHUM321580 GLEAN_03787
Stocks & Reagents
Stocks Listed in FlyBase ( 13 )
Bloomington	19062 w1118; PBac{WH}mpf07253 25289 w1118; Mi{ET1}mpMB08228 28299 y1 v1; P{TRiP.JF02929}attP2 22993 y1 w67c23; Mi{ET1}mpMB01109
Harvard	- PBac{PB}mpc01251 - PBac{WH}mpf03008 - PBac{WH}mpf07253
VDRC	v100846 P{KK103713}VIE-260B v107319 P{KK108613}VIE-260B v38188 w1118; P{GD6041}v38188 v38189 w1118; P{GD6041}v38189 v35431 w1118; P{GD12529}v35431
	More stocks available...
Genomic Clones ( 1 )
	BACR21K18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 48 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH14382 GM30371
Other clones	MIP14264 MIP16013 MIP20649
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH22760 RE29881 RE30207 RH02618 RH03141 RH03142 RH03204
Other clones	44112 57084 57961 66763 121103 145488 190119 214225.21 214347.19 214449.22 214471.68 CK01.31B.F3 CK01.100D.F6 CK01.116A.H2 EK027122 EK067704 EK085155 EK111106 EK159517 EK170617 EK180525 EK195026 EK205308 EK251216 EK292413 EP03801 EP04413 EP12520 EP18333 EP21337 GH19417 RH01311 RH01409 RP004254305 RP004256296 RP004502656
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0260660 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38767 38769
Antibody Information
	polyclonal (Momota et al., 2011)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: mp CG42543 (Meyer and Moussian, 2009)
Source for database merge of	Source for merge of: CG8645 CG14822 (FlyBase Genome Annotators, 2002-2003) Source for merge of: CG33171 CG8647 (FlyBase Genome Annotators, 2009)
Additional comments	Annotations CG33171 and CG8647 merged as CG42543 in release 5.15 of the genome annotation. (FlyBase Genome Annotators, 2009) Annotations CG8645 and CG14822 merged as CG33171 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_176293 NM_176294 NM_001169885 NM_001169886 NM_001169887 NM_001169888 NM_001169889 NM_001169890 NM_001169892 NM_001169893 RefSeq (Proteins) • NP_788471 NP_788472 NP_001163356 NP_001163357 NP_001163358 NP_001163359 NP_001163360 NP_001163361 NP_001163363 NP_001163364 DDBJ / EMBL / GenBank • AAM48339 AAM50734 AAO41273 AAO41274 ACZ94627 ACZ94628 ACZ94629 ACZ94630 ACZ94631 ACZ94632 ACZ94633 ACZ94634 ACZ94635 AI238354 AY118310 AY118874 BI355320 CZ485566 CZ490064 CZ490065 Entrez Gene - A searchable database of RefSeq genes. • 38769 UniProtKB/TrEMBL • E1JI49 E1JI50 E1JI51 E1JI52 E1JID9 E1JIE0 E1JIE1 E1JIE2 E1JIE3 Q8MSE3 Q8MT89 Q86BH1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Collagen triple helix repeat (IPR008160) Collagenase NC10/endostatin (IPR010515) C-type lectin-like (IPR016186) C-type lectin fold (IPR016187) Laminin G, thrombospondin-type, N-terminal (IPR003129) Concanavalin A-like lectin/glucanase (IPR008985)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0260660 DRSC - Results from RNAi screens. • FBgn0260660 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0260660 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0260660 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38767 38769 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38769 modMine - Data generated by the modENCODE project. • FBgn0260660 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV16687 LH20456 FBgn0238843 FBgn0218648 FBgn0200359 FBgn0185684 FBgn0169734 JGI_V11_48387 JGI_V11_48458 JGI_V11_15160 FBgn0244988 FBgn0162607 FBgn0135747 FBgn0122857 FBgn0106658 FBgn0101996 CPIJ005619 BGIBMGA012062 ACYPI49091 GB18123 AGAP006516 AAEL002256 PB23441 PHUM321580 GLEAN_03787
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG8645 (Sano et al., 2005) CG8647 (Momota et al., 2011, Meyer and Moussian, 2009, Keleman et al., 2009.8.5) CG14822   CG33171 (Momota et al., 2011, Tanji et al., 2006, Kwon et al., 2008, Meyer and Moussian, 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Cammarato et al., 2011) CG42543 (FlyBase Genome Annotators, 2009, Gilliland et al., 2009) CT14872 (Hynes and Zhao, 2000) Dmp (Meyer and Moussian, 2009) mp (Momota et al., 2011, )
Name Synonym	CG8647   CG33171   Collagen-like (Sano et al., 2005) multiplexin (Meyer and Moussian, 2009)
Secondary FlyBase IDs
	FBgn0035729 FBgn0035731 FBgn0035732 FBgn0053171
References ( 28 )
Generate a list of	All references relating to this gene ( 28 )
List References by type	Research paper  ( 6 ) Supplementary material  ( 3 ) Review  ( 1 ) Personal communication to FlyBase  ( 8 ) FlyBase analysis  ( 4 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 1 )
	Momota et al., 2011, Matrix Biol. 30(4): 258--266 Drosophila type XV/XVIII collagen, Mp, is involved in Wingless distribution. [FBrf0213898] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...