FB2021_02, released April 13, 2021

Gene: Dmel\GC1

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General Information
Symbol
Dmel\GC1
Species
D. melanogaster
Name
Glutamate Carrier 1
Annotation Symbol
CG18347
Feature Type
protein_coding_gene
FlyBase ID
FBgn0260743
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Summary
Glutamate Carrier 1 (GC1) encodes a carrier protein of the inner mitochondrial membrane that transports L-glutamate either with H[+] or in exchange for OH[-]. It operates during uricogenesis and has an essential role in the mitochondrial glutamate metabolism. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

DmGC1, anon-87Ac

Key Links
Genomic Location
Cytogenetic map
87A3-87A4
Sequence location
3R:11,967,708..11,971,686 [+]
Recombination map
3-51
RefSeq locus
NT_033777 REGION:11967708..11971686
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (8 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables high-affinity glutamate transmembrane transporter activity
inferred from direct assay
(Lunetti et al., 2013)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables L-aspartate transmembrane transporter activity
inferred from biological aspect of ancestor with PANTHER:PTN000640306
(assigned by GO_Central )
(Gaudet et al., 2011)
enables L-glutamate transmembrane transporter activity
inferred from biological aspect of ancestor with PANTHER:PTN000640306
(assigned by GO_Central )
(Gaudet et al., 2011)
enables transmembrane transporter activity
inferred from biological aspect of ancestor with PANTHER:PTN000640304
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in L-glutamate transmembrane transport
inferred from mutant phenotype
(Lunetti et al., 2013)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in aspartate transmembrane transport
inferred from biological aspect of ancestor with PANTHER:PTN000640306
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in L-glutamate transmembrane transport
inferred from biological aspect of ancestor with PANTHER:PTN000640306
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in malate-aspartate shuttle
inferred from biological aspect of ancestor with PANTHER:PTN000640306
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in mitochondrial inner membrane
inferred from sequence or structural similarity with MGI:MGI:1919053
(FlyBase Curators, 2008--)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Glutamate Carrier 1 (GC1) encodes a carrier protein of the inner mitochondrial membrane that transports L-glutamate either with H[+] or in exchange for OH[-]. It operates during uricogenesis and has an essential role in the mitochondrial glutamate metabolism. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
SLC25 FAMILY OF MITOCHONDRIAL TRANSPORTERS -
The solute carrier family 25 (SLC25) or mitochondrial carrier family (MCF) members shuttle metabolites, nucleotides and cofactors across the inner mitochondrial membrane. (Adapted from FBrf0212481, FBrf0212949 and PMID:23266187).
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\GC1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.47

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
GC1-RA
FBtr0082484
NM_141877
1450
321
GC1-RB
FBtr0334153
NM_001275561
1658
321
Additional Transcript Data and Comments
Reported size (kB)

1.95 (longest cDNA)

(Glover et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
GC1-PA
FBpp0081958
34.6
321
10.08
NP_650134
AAF54725
GC1-PB
FBpp0306270
34.6
321
10.08
NP_001262490
AGB95872
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

321 aa isoforms: GC1-PA, GC1-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\GC1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\GC1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of GC1
Transgenic constructs containing regulatory region of GC1
Aberrations (Deficiencies and Duplications) ( 2 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
partially lethal, with Scer\GAL4tin.CΔ4
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Other Phenotypes
Allele
short lived | heat sensitive, with Scer\GAL4tin.CΔ4
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
trichogen cell, with Scer\GAL4pnr-MD237
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\SLC25A22
14 of 15
Yes
Yes
Hsap\SLC25A18
11 of 15
No
Yes
1  
Hsap\SLC25A12
1 of 15
No
No
Hsap\SLC25A13
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Slc25a22
13 of 15
Yes
Yes
Mmus\Slc25a18
10 of 15
No
Yes
Mmus\Slc25a12
1 of 15
No
No
Mmus\Slc25a13
1 of 15
No
No
Rattus norvegicus (Norway rat) (3)
Rnor\Slc25a18
9 of 13
Yes
No
Rnor\Slc25a22
9 of 13
Yes
Yes
Rnor\LOC100911440
4 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (5)
Xtro\slc25a18
9 of 12
Yes
Yes
Xtro\slc25a22
7 of 12
No
No
Xtro\slc25a22
3 of 12
No
Yes
Xtro\slc25a12
1 of 12
No
No
Xtro\slc25a13
1 of 12
No
No
Danio rerio (Zebrafish) (5)
Drer\slc25a55a
11 of 15
Yes
Yes
Drer\slc25a55b
11 of 15
Yes
Yes
Drer\slc25a18
10 of 15
No
Yes
Drer\slc25a22a
10 of 15
No
Yes
Drer\slc25a22b
7 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\slc-25A18.1
14 of 15
Yes
Yes
Cele\slc-25A18.2
10 of 15
No
Yes
Cele\K02F3.2
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (1)
Atha\mSFC1
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\AGC1
3 of 15
Yes
No
Scer\GGC1
1 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190CTP )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00010339
Drosophila simulans
Dsim\GD18793
Drosophila sechellia
Dsec\GM23990
Drosophila erecta
Dere\GG18542
Drosophila yakuba
Dyak\GE26151
Drosophila ananassae
Dana\GF23042
Drosophila pseudoobscura pseudoobscura
Dpse\GA14898
Drosophila persimilis
Dper\GL22257
Drosophila persimilis
Dper\GL22256
Drosophila willistoni
Dwil\GK11426
Drosophila virilis
Dvir\GJ23511
Drosophila mojavensis
Dmoj\GI23551
Drosophila grimshawi
Dgri\GH23533
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091507MZ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17020676
Glossina morsitans
Tsetse fly
Gmor\GMOY011152
Glossina morsitans
Tsetse fly
Gmor\GMOY005912
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_01222
Mayetiola destructor
Hessian fly
Mdes\Mdes009897
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL011276
Anopheles darlingi
American malaria mosquito
Adar\ADAC001543
Anopheles gambiae
Malaria mosquito
Agam\AGAP010293
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ017288
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0AAY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA010248
Danaus plexippus
Monarch butterfly
Dple\DPOGS204677-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL017597
Apis florea
Little honeybee
Aflo\2856373444
Apis mellifera
Western honey bee
Amel\GB42400
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP11927
Bombus terrestris
Buff-tailed bumblebee
Bter\15216870
Linepithema humile
Argentine ant
Lhum\LH11975
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001c7c
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG000865
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11379
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11383
Tribolium castaneum
Red flour beetle
Tcas\TC013175
Pediculus humanus
Human body louse
Phum\PHUM598620
Cimex lectularius
Bed bug
Clec\CLEC009013
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004157
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_00512
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X07WV )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ixodes scapularis
Black-legged tick
Isca\ISCW018293
Stegodyphus mimosarum
African social velvet spider
Smim\KFM82566.1
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_227291
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G08GT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc25a12_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc25a22
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc25a12
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_020158gn
Ciona intestinalis
Vase tunicate
Cint\LOC100186157
Ciona intestinalis
Vase tunicate
Cint\LOC100184180
Gallus gallus
Domestic chicken
Ggal\SLC25A12
Gallus gallus
Domestic chicken
Ggal\SLC25A22
Gallus gallus
Domestic chicken
Ggal\SLC25A13
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (43)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
GC2
7 of 10
aralar1
3 of 10
Ant2
1 of 10
Bmcp
1 of 10
CG1628
1 of 10
CG1907
1 of 10
CG2616
1 of 10
CG4743
1 of 10
CG4995
1 of 10
CG5254
1 of 10
CG5805
1 of 10
CG6893
1 of 10
CG7514
1 of 10
CG7943
1 of 10
CG8026
1 of 10
CG8323
1 of 10
CG9582
1 of 10
CG16736
1 of 10
CG18324
1 of 10
CG18327
1 of 10
CG18418
1 of 10
colt
1 of 10
Dic1
1 of 10
Dic2
1 of 10
Dic3
1 of 10
Dic4
1 of 10
DPCoAC
1 of 10
mfrn
1 of 10
MME1
1 of 10
Mpcp1
1 of 10
Mpcp2
1 of 10
PMP34
1 of 10
Rim2
1 of 10
SCaMC
1 of 10
sea
1 of 10
sesB
1 of 10
Shawn
1 of 10
Tpc1
1 of 10
Tpc2
1 of 10
Tyler
1 of 10
Ucp4A
1 of 10
Ucp4B
1 of 10
Ucp4C
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SLC25A22; solute carrier family 25 member 22
    14 of 15
    609302
    SLC25A18; solute carrier family 25 member 18
    11 of 15
    609303
         
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Interactions Browser
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3R
        Recombination map
        3-51
        Cytogenetic map
        87A3-87A4
        Sequence location
        3R:11,967,708..11,971,686 [+]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        87A3-87A4
        Limits computationally determined from genome sequence between P{EP}Lk6EP886 and P{PZ}svp07842
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        87A7-87A9
        (Glover et al., 1995)
        Experimentally Determined Recombination Data
        Location

        3-51

        (FlyBase, 2016)

        3-48.9

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (7)
        Genomic Clones (23)
        cDNA Clones (25)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of

        Source for identity of: GC1 CG18347

        (Lunetti et al., 2013)
        Source for database merge of

        Source for merge of: CG18347 anon-87Ac

        (FlyBase, 1996-)
        Additional comments

        Source for merge of CG18347 anon-87Ac was comparison of the chromosomal walk and transformation fragments shown in Figure 1. of FBrf0080055 with the corresponding region of the release 5.14 D.melanogaster genome.

        (FlyBase, 1996-)
        Other Comments

        Identified during molecular analysis of aur.

        (Glover et al., 1995)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 32 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        FlyMine - An integrated database for Drosophila genomics
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DPiM - Drosophila Protein interaction map
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Synonyms and Secondary IDs (6)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (46)