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Gene Dmel\wisp

General Information
Symbol	Dmel\wisp	Species	D. melanogaster
Name	wispy	Annotation symbol	CG15737
Feature type	protein_coding_gene	FlyBase ID	FBgn0260780
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	fs(1)M19
Genomic Location
Chromosome (arm)	X	Recombination map	1-37
Cytogenetic map	10F4-10F7	Sequence location	X:11,787,978..11,793,943 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene wispy is referred to in FlyBase by the symbol Dmel\wisp (CG15737, FBgn0260780). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: polynucleotide adenylyltransferase activity. There is experimental evidence for 12 unique biological process terms, many of which group under: cellular component organization or biogenesis; localization; gene expression; cell cycle; primary metabolic process; single fertilization; cellular localization; organelle organization; nitrogen compound metabolic process; biological regulation; microtubule-based process; cell activation; multicellular organism reproduction. 23 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; meiotic metaphase I; centrosome; spindle; mesothoracic tergum; female pronucleus. It has one annotated transcript and one annotated polypeptide. Protein features are: PAP/25A-associated. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of extremely low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1631125_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of wisp. Gene sequence location is X:11787978..11793943.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	Controlled Vocabulary Terms female organism embryonic stage oocyte ovary adult stage
FB2012_01	References Wong et al., 2011, PLoS ONE 6(9): e24355 Thomsen et al., 2010, Genome Biol. 11(9): R93 Sequence features BKN21499 HFA19703
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 10F4-10F7   Limits computationally determined from genome sequence between P{EP}ATP7EP308 and P{EP}EP1451&P{EP}EP1629; Left limit from inclusion within Df(1)RA47 (FBrf0127024) Right limit from non-inclusion within Df(1)N105 (FBrf0127024)
Experimentally Determined Cytological Location
Cytogenetic map Notes References 11A1-11A2   (determined by in situ hybridisation)   (Peter et al., 2002)
Experimentally Determined Recombination Data
Location	1-37   1- (Mohler, 1977)
Left of (cM)	f (Mohler, 1977)
Right of (cM)	v (Mohler, 1977)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\wisp for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	DGC clone appears problematic (LD18468): probable incomplete CDS.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) wisp-RA FBtr0073573  NM_132538   5119   1373
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein wisp-PA   FBpp0073417   151.3   1373   8.91     NP_572766   AAF48114
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • PAP/25A-associated (IPR002058)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA538846   AE014298 AAF48114   AI511639   AI518735   AI520399   AI544204   AW942486   BG639077   BG639229   BI164077   BI172369   BI231989   BI374373   BQ103114   BQ103118   BQ103574   CL528237   CO190584   CO262110   CO264664   CO267468   CO272227   CO282178   CO282781   CO286667   CO287896   CO291222   CO306677   CO309091   CO313727   CO326357   CO343401   EC052531   EC058054   EC071826   EC076438   EC198525   EC210960   EC225586   EC227060   EC233684   EC241382   EC245402   EC248883   EC249673   EC255339   EV584051   EV585490   EV597235   EY199003
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VYS4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
RT-PCR Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism   (Cui et al., 2008) adult stage | female   organism   (Cui et al., 2008)
Additional Descriptive Data
	A long form of wisp transcript detected by 3' primers is present in embryos and in adult females but not males. Primers containing sequences further 5' in the gene detect transcripts in males and females but the corresponding shorter transcript form was not characterized. (Cui et al., 2008)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism   (Cui et al., 2008) adult stage | female   organism   (Cui et al., 2008) ovary   (Cui et al., 2008) oocyte   (Cui et al., 2008)
Additional Descriptive Data
	wisp protein is detected in ovarian oocytes. (Cui et al., 2008)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0260780    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0260780 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of extremely low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0260780 expression level Developmental Stage   Expression Level embryo 00-02hr    19427 embryo 02-04hr    13125 embryo 04-06hr    1831 embryo 06-08hr    1003 embryo 08-10hr    1103 embryo 10-12hr    364 embryo 12-14hr    584 embryo 14-16hr    1085 embryo 16-18hr    608 embryo 18-20hr    328 embryo 20-22hr    948 embryo 22-24hr    669 larva L1    7 larva L2    6 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    7 white prepupae new    11 white prepupae 12hr    16 white prepupae 24hr    26 pupae 2d postWPP    37 pupae 3d postWPP    21 pupae 4d postWPP    141 adult male 01day    32 adult male 05day    30 adult male 30day    71 adult female 01day    6609 adult female 05day    11491 adult female 30day    11346 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (19427) embryo 02-04hr  (13125) embryo 04-06hr  (1831) embryo 06-08hr  (1003) embryo 08-10hr  (1103) embryo 10-12hr  (364) embryo 12-14hr  (584) embryo 14-16hr  (1085) embryo 16-18hr  (608) embryo 18-20hr  (328) embryo 20-22hr  (948) embryo 22-24hr  (669) larva L1    7 larva L2    6 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    7 white prepupae new    11 white prepupae 12hr    16 white prepupae 24hr    26 pupae 2d postWPP    37 pupae 3d postWPP    21 pupae 4d postWPP  (141) adult male 01day    32 adult male 05day    30 adult male 30day    71 adult female 01day  (6609) adult female 05day  (11491) adult female 30day  (11346) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (19427) embryo 02-04hr  (13125) embryo 04-06hr  (1831) embryo 06-08hr    1003 embryo 08-10hr    1103 embryo 10-12hr    364 embryo 12-14hr    584 embryo 14-16hr    1085 embryo 16-18hr    608 embryo 18-20hr    328 embryo 20-22hr    948 embryo 22-24hr    669 larva L1    7 larva L2    6 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    7 white prepupae new    11 white prepupae 12hr    16 white prepupae 24hr    26 pupae 2d postWPP    37 pupae 3d postWPP    21 pupae 4d postWPP    141 adult male 01day    32 adult male 05day    30 adult male 30day    71 adult female 01day  (6609) adult female 05day  (11491) adult female 30day  (11346) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (19427) embryo 02-04hr  (13125) embryo 04-06hr    1831 embryo 06-08hr    1003 embryo 08-10hr    1103 embryo 10-12hr    364 embryo 12-14hr    584 embryo 14-16hr    1085 embryo 16-18hr    608 embryo 18-20hr    328 embryo 20-22hr    948 embryo 22-24hr    669 larva L1    7 larva L2    6 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    7 white prepupae new    11 white prepupae 12hr    16 white prepupae 24hr    26 pupae 2d postWPP    37 pupae 3d postWPP    21 pupae 4d postWPP    141 adult male 01day    32 adult male 05day    30 adult male 30day    71 adult female 01day    6609 adult female 05day  (11491) adult female 30day  (11346) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    19427 embryo 02-04hr    13125 embryo 04-06hr    1831 embryo 06-08hr    1003 embryo 08-10hr    1103 embryo 10-12hr    364 embryo 12-14hr    584 embryo 14-16hr    1085 embryo 16-18hr    608 embryo 18-20hr    328 embryo 20-22hr    948 embryo 22-24hr    669 larva L1    7 larva L2    6 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    7 white prepupae new    11 white prepupae 12hr    16 white prepupae 24hr    26 pupae 2d postWPP    37 pupae 3d postWPP    21 pupae 4d postWPP    141 adult male 01day    32 adult male 05day    30 adult male 30day    71 adult female 01day    6609 adult female 05day    11491 adult female 30day    11346 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0260780 expression level Developmental Stage   Expression Level embryo 00-02hr    19427 embryo 02-04hr    13125 embryo 04-06hr    1831 embryo 06-08hr    1003 embryo 08-10hr    1103 embryo 10-12hr    364 embryo 12-14hr    584 embryo 14-16hr    1085 embryo 16-18hr    608 embryo 18-20hr    328 embryo 20-22hr    948 embryo 22-24hr    669 larva L1    7 larva L2    6 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    7 white prepupae new    11 white prepupae 12hr    16 white prepupae 24hr    26 pupae 2d postWPP    37 pupae 3d postWPP    21 pupae 4d postWPP    141 adult male 01day    32 adult male 05day    30 adult male 30day    71 adult female 01day    6609 adult female 05day    11491 adult female 30day    11346 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (19427) embryo 02-04hr  (13125) embryo 04-06hr  (1831) embryo 06-08hr  (1003) embryo 08-10hr  (1103) embryo 10-12hr  (364) embryo 12-14hr  (584) embryo 14-16hr  (1085) embryo 16-18hr  (608) embryo 18-20hr  (328) embryo 20-22hr  (948) embryo 22-24hr  (669) larva L1    7 larva L2    6 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    7 white prepupae new    11 white prepupae 12hr    16 white prepupae 24hr    26 pupae 2d postWPP    37 pupae 3d postWPP    21 pupae 4d postWPP  141 adult male 01day    32 adult male 05day    30 adult male 30day    71 adult female 01day  (6609) adult female 05day  (11491) adult female 30day  (11346) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (19427) embryo 02-04hr  (13125) embryo 04-06hr  1831 embryo 06-08hr    1003 embryo 08-10hr    1103 embryo 10-12hr    364 embryo 12-14hr    584 embryo 14-16hr    1085 embryo 16-18hr    608 embryo 18-20hr    328 embryo 20-22hr    948 embryo 22-24hr    669 larva L1    7 larva L2    6 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    7 white prepupae new    11 white prepupae 12hr    16 white prepupae 24hr    26 pupae 2d postWPP    37 pupae 3d postWPP    21 pupae 4d postWPP    141 adult male 01day    32 adult male 05day    30 adult male 30day    71 adult female 01day  (6609) adult female 05day  (11491) adult female 30day  (11346) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  19427 embryo 02-04hr  13125 embryo 04-06hr    1831 embryo 06-08hr    1003 embryo 08-10hr    1103 embryo 10-12hr    364 embryo 12-14hr    584 embryo 14-16hr    1085 embryo 16-18hr    608 embryo 18-20hr    328 embryo 20-22hr    948 embryo 22-24hr    669 larva L1    7 larva L2    6 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    7 white prepupae new    11 white prepupae 12hr    16 white prepupae 24hr    26 pupae 2d postWPP    37 pupae 3d postWPP    21 pupae 4d postWPP    141 adult male 01day    32 adult male 05day    30 adult male 30day    71 adult female 01day    6609 adult female 05day  11491 adult female 30day  11346 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    19427 embryo 02-04hr    13125 embryo 04-06hr    1831 embryo 06-08hr    1003 embryo 08-10hr    1103 embryo 10-12hr    364 embryo 12-14hr    584 embryo 14-16hr    1085 embryo 16-18hr    608 embryo 18-20hr    328 embryo 20-22hr    948 embryo 22-24hr    669 larva L1    7 larva L2    6 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    7 white prepupae new    11 white prepupae 12hr    16 white prepupae 24hr    26 pupae 2d postWPP    37 pupae 3d postWPP    21 pupae 4d postWPP    141 adult male 01day    32 adult male 05day    30 adult male 30day    71 adult female 01day    6609 adult female 05day    11491 adult female 30day    11346 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0260780    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0260780 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0260780 expression level Tissue   Expression Level Larval Central Nervous System    5.15 Larval Midgut    6.1 Larval Hindgut    3.4 Larval Malpighian Tubules    5.4 Larval Fat Body no informative data Larval Salivary Gland    4.3 Larval Trachea    4.2 Larval Carcass    4.7 Adult Head    3.3 Adult Eye    6.85 Adult Brain    9.5 Adult Thoracic-Abdominal Ganglion    9.1 Adult Crop    6.5 Adult Midgut    6.8 Adult Hindgut    3.4 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    4.1 Adult Heart    3.5 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    6.7 Adult Ovary    1059.8 Adult Testis    30.9 Adult Male Accessory Gland    2.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    5.15 Larval Midgut    6.1 Larval Hindgut    3.4 Larval Malpighian Tubules    5.4 Larval Fat Body no informative data Larval Salivary Gland    4.3 Larval Trachea    4.2 Larval Carcass    4.7 Adult Head    3.3 Adult Eye    6.85 Adult Brain    9.5 Adult Thoracic-Abdominal Ganglion    9.1 Adult Crop    6.5 Adult Midgut    6.8 Adult Hindgut    3.4 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    4.1 Adult Heart    3.5 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    6.7 Adult Ovary  (1059.8) Adult Testis    30.9 Adult Male Accessory Gland    2.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    5.15 Larval Midgut    6.1 Larval Hindgut    3.4 Larval Malpighian Tubules    5.4 Larval Fat Body no informative data Larval Salivary Gland    4.3 Larval Trachea    4.2 Larval Carcass    4.7 Adult Head    3.3 Adult Eye    6.85 Adult Brain    9.5 Adult Thoracic-Abdominal Ganglion    9.1 Adult Crop    6.5 Adult Midgut    6.8 Adult Hindgut    3.4 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    4.1 Adult Heart    3.5 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    6.7 Adult Ovary  1059.8 Adult Testis    30.9 Adult Male Accessory Gland    2.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    5.15 Larval Midgut    6.1 Larval Hindgut    3.4 Larval Malpighian Tubules    5.4 Larval Fat Body no informative data Larval Salivary Gland    4.3 Larval Trachea    4.2 Larval Carcass    4.7 Adult Head    3.3 Adult Eye    6.85 Adult Brain    9.5 Adult Thoracic-Abdominal Ganglion    9.1 Adult Crop    6.5 Adult Midgut    6.8 Adult Hindgut    3.4 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    4.1 Adult Heart    3.5 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    6.7 Adult Ovary    1059.8 Adult Testis    30.9 Adult Male Accessory Gland    2.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0260780 expression level Tissue   Expression Level Larval Central Nervous System    5.15 Larval Midgut    6.1 Larval Hindgut    3.4 Larval Malpighian Tubules    5.4 Larval Fat Body no informative data Larval Salivary Gland    4.3 Larval Trachea    4.2 Larval Carcass    4.7 Adult Head    3.3 Adult Eye    6.85 Adult Brain    9.5 Adult Thoracic-Abdominal Ganglion    9.1 Adult Crop    6.5 Adult Midgut    6.8 Adult Hindgut    3.4 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    4.1 Adult Heart    3.5 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    6.7 Adult Ovary    1059.8 Adult Testis    30.9 Adult Male Accessory Gland    2.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    5.15 Larval Midgut    6.1 Larval Hindgut    3.4 Larval Malpighian Tubules    5.4 Larval Fat Body no informative data Larval Salivary Gland    4.3 Larval Trachea    4.2 Larval Carcass    4.7 Adult Head    3.3 Adult Eye    6.85 Adult Brain    9.5 Adult Thoracic-Abdominal Ganglion    9.1 Adult Crop    6.5 Adult Midgut    6.8 Adult Hindgut    3.4 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    4.1 Adult Heart    3.5 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    6.7 Adult Ovary  (1059.8) Adult Testis    30.9 Adult Male Accessory Gland    2.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    5.15 Larval Midgut    6.1 Larval Hindgut    3.4 Larval Malpighian Tubules    5.4 Larval Fat Body no informative data Larval Salivary Gland    4.3 Larval Trachea    4.2 Larval Carcass    4.7 Adult Head    3.3 Adult Eye    6.85 Adult Brain    9.5 Adult Thoracic-Abdominal Ganglion    9.1 Adult Crop    6.5 Adult Midgut    6.8 Adult Hindgut    3.4 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    4.1 Adult Heart    3.5 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    6.7 Adult Ovary  1059.8 Adult Testis    30.9 Adult Male Accessory Gland    2.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    5.15 Larval Midgut    6.1 Larval Hindgut    3.4 Larval Malpighian Tubules    5.4 Larval Fat Body no informative data Larval Salivary Gland    4.3 Larval Trachea    4.2 Larval Carcass    4.7 Adult Head    3.3 Adult Eye    6.85 Adult Brain    9.5 Adult Thoracic-Abdominal Ganglion    9.1 Adult Crop    6.5 Adult Midgut    6.8 Adult Hindgut    3.4 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    4.1 Adult Heart    3.5 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    6.7 Adult Ovary    1059.8 Adult Testis    30.9 Adult Male Accessory Gland    2.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    3.3   NA  Eye    6.85   NA  Brain    9.5   5.15  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    9.1   NA  Crop    6.5   6.1  Midgut    6.8   3.4  Hindgut    3.4   5.4  Malpighian Tubules    no informative data   no informative data  Fat Body    no informative data   4.3  Salivary Gland    4.1   NA  Heart    3.5   4.2  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    6.7   NA  Ovary    1059.8   NA  Testis    30.9   NA  Male Accessory Gland    2.9   4.7  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_01
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0260780
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | maternal effect (with Df(1)RA47) wispKG05287 lethal | embryonic stage | maternal effect | recessive wisp1 wisp4 wisp6 wisp7 wisp9 wisp11-600 wisp11 wisp12-3147 wisp14-1299 lethal | embryonic stage | non-rescuable maternal effect | recessive wispKG05287 lethal | maternal effect | recessive wisp1 wisp3 wisp4 wisp5 wisp6 wisp7 wisp9 wisp11-600 wisp11 wisp12-3147 wisp14-1299 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 wispGD9101 viable wispKG05287 Sterility Allele female fertile wisp40 wisp89 female sterile | recessive wisp1 wisp3 wisp4 wisp5 wisp6 wisp7 wisp9 wisp11-600 wisp11 wisp12-3147 wisp14-1299 wispKG05287 male fertile wispKG05287 Other Phenotypes Allele meiotic cell cycle defective | recessive wisp11-600 wisp12-3147 wisp14-1299 mitotic cell cycle defective | recessive wisp11-600 wisp12-3147 wisp14-1299 visible, with Scer\GAL4pnr-MD237 wispGD9101 Phenotype manifest in Allele centrosome wisp11-600 wisp12-3147 wisp14-1299 egg | maternal effect wisp1 wisp11 wisp11-600 wisp12-3147 wisp14-1299 wisp4 wisp6 wisp7 wisp9 female pronucleus wisp11-600 wisp12-3147 wisp14-1299 meiosis & nuclear chromosome wisp11-600 wisp12-3147 wisp14-1299 meiotic cell cycle & aster wisp11-600 wisp12-3147 wisp14-1299 meiotic cell cycle & pericentriolar material wisp11-600 wisp12-3147 wisp14-1299 meiotic cell cycle & spindle wisp11-600 wisp12-3147 wisp14-1299 meiotic metaphase I wisp11-600 wisp12-3147 wisp14-1299 mesothoracic tergum, with Scer\GAL4pnr-MD237 wispGD9101 mitosis & nuclear chromosome wisp11-600 wisp12-3147 wisp14-1299 mitotic cell cycle & centrosome wisp11-600 wisp12-3147 wisp14-1299 mitotic cell cycle & spindle wisp11-600 wisp12-3147 wisp14-1299 spindle wisp11-600 wisp12-3147 wisp14-1299 spindle | ectopic wisp11-600 wisp14-1299 trichogen cell, with Scer\GAL4pnr-MD237 wispGD9101
Classical Alleles ( 21 )
For All Classical Alleles Show
Allele of wisp Class Mutagen Stocks Known lesion wisp12-3147 amorphic allele - genetic evidence ethyl methanesulfonate 1 Yes wispKG05287 amorphic allele - genetic evidence P-element activity 1 Yes wispCB-6172-3 1 -- wispG0113c P-element activity 1 -- wisp11-600 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- wisp14-1299 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- wisp248 amorphic allele - genetic evidence 0 Yes wisp41 amorphic allele - genetic evidence 0 Yes wisp11 ethyl methanesulfonate 0 -- wisp181 0 -- wisp1 ethyl methanesulfonate 0 -- wisp249 0 Yes wisp3 ethyl methanesulfonate 0 -- wisp40 P-element activity 0 Yes wisp4 ethyl methanesulfonate 0 -- wisp5 ethyl methanesulfonate 0 -- wisp6 ethyl methanesulfonate 0 -- wisp7 ethyl methanesulfonate 0 -- wisp89 P-element activity 0 Yes wisp9 ethyl methanesulfonate 0 -- wispunspecified 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of wisp Class Mutagen Stocks Known lesion wispGD9101 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes wispKK101448 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(1)Exel6243 (Ryder, 2004.4.26) Df(1)HA85 (Tadros et al., 2003) Df(1)KA6 (Brent et al., 2000, Tadros et al., 2003) Df(1)RA47 (Brent et al., 2000, Tadros et al., 2003, Benoit et al., 2008)
Not disrupted in	Df(1)m259-4 (Tadros et al., 2003) Df(1)N105 (Brent et al., 2000, Tadros et al., 2003)
Duplicated in	Dp(1;3)DC246 (Popodi et al., 2010-)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK101448} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{?SUPor-P}wisp40 NA P{?SUPor-P}wisp89 NA P{RS3}wispCB-6172-3 NA P{SUPor-P}wispKG05287 NA insertion of enhancer trap P{lacW}wispG0113c No
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 13 terms )
Molecular Function
CV term Evidence References
polynucleotide adenylyltransferase activity inferred from direct assay (Benoit et al., 2008)
Biological Process
CV term Evidence References
egg activation inferred from mutant phenotype (Tadros et al., 2003, Cui et al., 2008) intracellular mRNA localization inferred from mutant phenotype (Brent et al., 2000) microtubule-based process inferred from mutant phenotype (Hazelrigg et al., 1998) mitotic spindle organization inferred from mutant phenotype (Brent et al., 2000) mRNA polyadenylation inferred from mutant phenotype (Cui et al., 2008, Benoit et al., 2008) oocyte maturation inferred from mutant phenotype (Cui et al., 2008) pronuclear fusion inferred from mutant phenotype (Brent et al., 2000) pronuclear migration inferred from mutant phenotype (Brent et al., 2000, Cui et al., 2008) regulation of antimicrobial peptide biosynthetic process inferred from mutant phenotype (Valanne et al., 2010) RNA polyadenylation inferred from direct assay (Benoit et al., 2008) sperm aster formation inferred from mutant phenotype (Brent et al., 2000) spindle assembly involved in female meiosis inferred from mutant phenotype (Brent et al., 2000)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
polynucleotide adenylyltransferase activity inferred from sequence or structural similarity with worm gld-2 (Wang et al., 2002)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions wisp allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58557 DroID - A comprehensive database of gene and protein interactions. • FBgn0260780 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32152
Orthologs
Genome-wide drosophilid orthologs	Dana\GF21578 Dere\GG18455 Dgri\GH12744 Dmoj\GI15889 Dper\GL20158 Dvir\GJ16636 Dwil\GK25423 Dyak\GE15676
Curated drosophilid orthologs
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • BGIBMGA012377-PA Bombyx mori (silk worm) ENSBTAP00000008885 Bos taurus (bovine) CBP36582 Caenorhabditis briggsae (nematode) ENSCAFP00000013295 Canis familiaris (dog) ENSCINP00000003566 Ciona intestinalis (sea squirt) JA02655 Caenorhabditis japonica (nematode) DDB0205447 Dictyostelium discoideum (amoeba) 311781 Daphnia pulex (daphnia) ENSDARP00000072194 Danio rerio (zebra fish) ENSDARP00000096574 Danio rerio (zebra fish) 194626 Hypsipyla robusta (cedar shoot borer) ENSP00000296783 Homo sapiens (human) ENSMMUP00000034397 Macaca mulatta (rhesus monkey) ENSMUSP00000048124 Mus musculus (house mouse) XP_001605928.1 Nasonia vitripennis (wasp) PF10_0152 Plasmodium falciparum (protozoal parasite) PHUM009227-PA Pediculus humanus (human body louse) ENSPPYP00000017427 Pongo pygmaeus (orangutan) 96240 Phytophthora ramorum (sudden oak death pathogen) 158817 Phytophthora sojae (root rot pathogen) ENSPTRP00000048313 Pan troglodytes (chimpanzee) PVX_082550 Plasmodium vivax (protozoal parasite) ENSRNOP00000016135 Rattus norvegicus (norway rat) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0233245 FBgn0227382 FBgn0203820 FBgn0168176 FBgn0248031 FBgn0157753 FBgn0138638 FBgn0120223 FBgn0110669 FBgn0098578
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	16467 y1 P{SUPor-P}wispKG05287/FM7c 4613 y1 cv1 v1 wisp12-3147 f1/FM0 11822 w67c23 P{lacW}tlkG0113a P{lacW}G0113b P{lacW}wispG0113c, l(1)G0113G0113/FM7c
Kyoto	123961 w1118 P{RS3}wispCB-6172-3
VDRC	v105972 P{KK101448}VIE-260B v19584 w1118; P{GD9101}v19584
Genomic Clones ( 1 )
	BACR12H01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 45 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD38440 LD40548 RE03648 RE14825 RE25178 RE61943
Other clones	8376 31064 38204 44227 45388 104465 106249 120150 157409 164572 214417.7 CK01.60B.G9 CK01.60B.G11 Dmel_dig_009023_0662_1513 Dmel_dig_010985_0587_3410 Dmel_neb_014146_0856_1530 DMG2-chrX.12.114.a.1 EC052531 EK048725 EK063526 EK067047 EK076718 EK084418 EK106323 EK139833 EK150411 EK159723 EK161211 EK233915 EK251763 EK260258 EP03743 EP16722 LD18468 LD43113 LD47659 UUGC0512 UUGC0516 UUGC0982
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0260780 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32152 48236
Antibody Information
	polyclonal (Cui et al., 2008, Benoit et al., 2008)
Other Information
Discoverer
Etymology
	The gene is named "temprano", the Spanish word for "early", as mutant embryos show defects in the early syncytial stages. (Tadros et al., 2003) The gene is named "wispy" because of its mutant effects on spindle structures. (Brent et al., 2000)
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: wisp CG15737 (Cui et al., 2008) Source for merge of: wisp fs(1)M19 (Brent et al., 2000)
Additional comments
Other Comments
	wisp is required for elongation of the poly(A) tail of a number of maternal mRNAs (including bcd, Tl, tor) upon egg activation. wisp is also required during oogenesis to regulate the poly(A) tail length of mos during oocyte maturation. (Cui et al., 2008) sub mutants do not interact with alleles of γTub37C, αTub67C, msps, tacc or wisp. (Giunta et al., 2002) wisp is required to recruit or maintain known centrosomal proteins with two types of microtubule organising centers (MTOCs); the central MTOC that forms between the meiosis II tandem spindles and the centrosomes of the mitotic spindle. (Brent et al., 2000) Both the wisp and aim mutant phenotypes suggest that these genes play important structural or regulatory roles in functions performed by microtubules. (Hazelrigg et al., 1998) Maternal effect alleles cause embryos to arrest immediately following meiosis. Meiotic defects include perturbations of metaphase I arrest, and chromosome non-disjunction and loss. The astral array of microtubules between the two meiosis II spindles is small or missing, and lacks normal levels of gamma-tubulin and other centrosomal proteins normally present in this structure. After fertilization, long, wispy meiotic-like spindles form on the products of female meiosis. These embryos arrest with a small spindle formed on the haploid male pronucleus, as centrosomes of this spindle are lost in the nearby cytoplasm. (Hazelrigg et al., 1998)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132538 RefSeq (Proteins) • NP_572766 DDBJ / EMBL / GenBank • AA538846 AAF48114 AW942486 CL528237 Entrez Gene - A searchable database of RefSeq genes. • 32152 UniProtKB/TrEMBL • Q9VYS4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • PAP/25A-associated (IPR002058)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58557 DroID - A comprehensive database of gene and protein interactions. • FBgn0260780 DRSC - Results from RNAi screens. • FBgn0260780 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0260780 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0260780 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32152 48236 InParanoid A subset of ortholog calls from InParanoid. • BGIBMGA012377-PA Bombyx mori (silk worm) ENSBTAP00000008885 Bos taurus (bovine) CBP36582 Caenorhabditis briggsae (nematode) ENSCAFP00000013295 Canis familiaris (dog) ENSCINP00000003566 Ciona intestinalis (sea squirt) JA02655 Caenorhabditis japonica (nematode) DDB0205447 Dictyostelium discoideum (amoeba) 311781 Daphnia pulex (daphnia) ENSDARP00000072194 Danio rerio (zebra fish) ENSDARP00000096574 Danio rerio (zebra fish) 194626 Hypsipyla robusta (cedar shoot borer) ENSP00000296783 Homo sapiens (human) ENSMMUP00000034397 Macaca mulatta (rhesus monkey) ENSMUSP00000048124 Mus musculus (house mouse) XP_001605928.1 Nasonia vitripennis (wasp) PF10_0152 Plasmodium falciparum (protozoal parasite) PHUM009227-PA Pediculus humanus (human body louse) ENSPPYP00000017427 Pongo pygmaeus (orangutan) 96240 Phytophthora ramorum (sudden oak death pathogen) 158817 Phytophthora sojae (root rot pathogen) ENSPTRP00000048313 Pan troglodytes (chimpanzee) PVX_082550 Plasmodium vivax (protozoal parasite) ENSRNOP00000016135 Rattus norvegicus (norway rat) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32152 modMine - Data generated by the modENCODE project. • FBgn0260780 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0233245 FBgn0227382 FBgn0203820 FBgn0168176 FBgn0248031 FBgn0157753 FBgn0138638 FBgn0120223 FBgn0110669 FBgn0098578
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	CG15737 (Cui et al., 2008, Benoit et al., 2008, Keleman et al., 2009.8.5, Brandt, 2006, Valanne et al., 2010) DmCG15737 (Wang et al., 2002) fs(1)M19 (Mohler and Carroll, 1984, Mohler, 1977, ) TAMP (Valanne et al., 2010) wisp (Cui et al., 2008, Cui et al., 2008, Benoit et al., 2008, Popodi et al., 2010-, Thomsen et al., 2010)
Name Synonym	CG15737   female sterile(1)M19   temprano (Tadros et al., 2003) Toll pathway activation mediating protein (Valanne et al., 2010) wispy (Cui et al., 2008, Hazelrigg et al., 1998, Cui et al., 2008, Benoit et al., 2008)
Secondary FlyBase IDs
	FBgn0000835 FBgn0024180 FBgn0030353
References ( 31 )
Generate a list of	All references relating to this gene ( 31 )
List References by type	Research paper  ( 11 ) Supplementary material  ( 5 ) Review  ( 1 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 2 ) FlyBase analysis  ( 2 ) Computer file  ( 2 ) Book  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 3 )
	Wong et al., 2011, PLoS ONE 6(9): e24355 The Functioning of the Drosophila CPEB Protein Orb Is Regulated by Phosphorylation and Requires Casein Kinase 2 Activity. [FBrf0216252] Thomsen et al., 2010, Genome Biol. 11(9): R93 Genome-wide analysis of mRNA decay patterns during early Drosophila development. [FBrf0212195] Valanne et al., 2010, J. Immunol. 184(11): 6188--6198 Genome-wide RNA interference in Drosophila cells identifies G protein-coupled receptor kinase 2 as a conserved regulator of NF-kappaB signaling. [FBrf0210846] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...