poly(A) polymerase acting on specific mRNA targets during late oogenesis and early embryogenesis - required at the final stage of oogenesis for metaphase during meiosis I arrest - interacts with Orb genetically and physically in an ovarian complex.
Gene model reviewed during 5.51
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Interacts with orb, an RNA-binding protein, generating an ovarian cytoplasmic polyadenylation complex.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\wisp using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\wisp in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
wisp is required to recruit or maintain known centrosomal proteins with two types of microtubule organising centers (MTOCs); the central MTOC that forms between the meiosis II tandem spindles and the centrosomes of the mitotic spindle.
Maternal effect alleles cause embryos to arrest immediately following meiosis. Meiotic defects include perturbations of metaphase I arrest, and chromosome non-disjunction and loss. The astral array of microtubules between the two meiosis II spindles is small or missing, and lacks normal levels of gamma-tubulin and other centrosomal proteins normally present in this structure. After fertilization, long, wispy meiotic-like spindles form on the products of female meiosis. These embryos arrest with a small spindle formed on the haploid male pronucleus, as centrosomes of this spindle are lost in the nearby cytoplasm.