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Gene Dmel\mxc

General Information
Symbol	Dmel\mxc	Species	D. melanogaster
Name	multi sex combs	Annotation symbol	CG12124
Feature type	protein_coding_gene	FlyBase ID	FBgn0260789
Gene Model Status	Current	Stock availability	12 publicly available
Also Known As	l(1)mbn
Genomic Location
Chromosome (arm)	X	Recombination map	1-27.7
Cytogenetic map	8D2-8D2	Sequence location	X:9,130,834..9,137,237 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene multi sex combs is referred to in FlyBase by the symbol Dmel\mxc (CG12124, FBgn0260789). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: DNA binding. There is experimental evidence that it is involved in the biological process: lateral inhibition; hemocyte differentiation; hemocyte proliferation; neurogenesis. 14 alleles are reported. The phenotypes of these alleles are annotated with: organ system; adult segment; organ system subdivision; imaginal precursor; embryonic/larval hemocoel; thoracic segment; eo support cell; male accessory gland; embryonic/larval fat body; cell part; acellular anatomical structure; prothoracic leg disc; external compound sense organ; late extended germ band embryo. It has one annotated transcript and one annotated polypeptide. Protein features are: AT hook, DNA-binding motif; LisH dimerisation motif. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1641346_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of mxc. Gene sequence location is X:9130834..9137237.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593
FB2012_01	Sequence features BKN45217 HFA17819 BKN23307
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 8D2-8D2   Limits computationally determined from genome sequence between P{EP}EP1450&P{EP}EP1356 and P{EP}EP912EP912
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	1-27.7
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\mxc for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	EST data suggest additional 3' exon(s)
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) mxc-RA FBtr0071332  NM_132320   5974   1837
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein mxc-PA   FBpp0071267   197.5   1837   6.41     NP_572548   AAF46472
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • LisH dimerisation motif (IPR006594) AT hook, DNA-binding motif (IPR017956)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA940955   AA951543   AE014298 AAF46472   AI515450   BG639222   BI608808   BI615403   BI626160   BI630935   BI637159   BI639832   BT011110   CK131384   CO185632   CO299184   CO330281   EC227870   EC259723   EV575510   EV584312   EW712787
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W363
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0260789    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0260789 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0260789 expression level Developmental Stage   Expression Level embryo 00-02hr    3147 embryo 02-04hr    1400 embryo 04-06hr    1885 embryo 06-08hr    1801 embryo 08-10hr    1194 embryo 10-12hr    474 embryo 12-14hr    519 embryo 14-16hr    441 embryo 16-18hr    314 embryo 18-20hr    139 embryo 20-22hr    352 embryo 22-24hr    430 larva L1    168 larva L2    165 larva L3 12hr old    130 larva L3 puffstage 1-2    140 larva L3 puffstage 3-6    262 larva L3 puffstage 7-9    265 white prepupae new    256 white prepupae 12hr    405 white prepupae 24hr    497 pupae 2d postWPP    244 pupae 3d postWPP    131 pupae 4d postWPP    88 adult male 01day    105 adult male 05day    135 adult male 30day    140 adult female 01day    659 adult female 05day    1655 adult female 30day    1752 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3147) embryo 02-04hr  (1400) embryo 04-06hr  (1885) embryo 06-08hr  (1801) embryo 08-10hr  (1194) embryo 10-12hr  (474) embryo 12-14hr  (519) embryo 14-16hr  (441) embryo 16-18hr  (314) embryo 18-20hr  (139) embryo 20-22hr  (352) embryo 22-24hr  (430) larva L1  (168) larva L2  (165) larva L3 12hr old  (130) larva L3 puffstage 1-2  (140) larva L3 puffstage 3-6  (262) larva L3 puffstage 7-9  (265) white prepupae new  (256) white prepupae 12hr  (405) white prepupae 24hr  (497) pupae 2d postWPP  (244) pupae 3d postWPP  (131) pupae 4d postWPP    88 adult male 01day  105 adult male 05day  (135) adult male 30day  (140) adult female 01day  (659) adult female 05day  (1655) adult female 30day  (1752) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3147) embryo 02-04hr    1400 embryo 04-06hr  (1885) embryo 06-08hr  (1801) embryo 08-10hr    1194 embryo 10-12hr    474 embryo 12-14hr    519 embryo 14-16hr    441 embryo 16-18hr    314 embryo 18-20hr    139 embryo 20-22hr    352 embryo 22-24hr    430 larva L1    168 larva L2    165 larva L3 12hr old    130 larva L3 puffstage 1-2    140 larva L3 puffstage 3-6    262 larva L3 puffstage 7-9    265 white prepupae new    256 white prepupae 12hr    405 white prepupae 24hr    497 pupae 2d postWPP    244 pupae 3d postWPP    131 pupae 4d postWPP    88 adult male 01day    105 adult male 05day    135 adult male 30day    140 adult female 01day    659 adult female 05day  (1655) adult female 30day  (1752) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3147 embryo 02-04hr    1400 embryo 04-06hr    1885 embryo 06-08hr    1801 embryo 08-10hr    1194 embryo 10-12hr    474 embryo 12-14hr    519 embryo 14-16hr    441 embryo 16-18hr    314 embryo 18-20hr    139 embryo 20-22hr    352 embryo 22-24hr    430 larva L1    168 larva L2    165 larva L3 12hr old    130 larva L3 puffstage 1-2    140 larva L3 puffstage 3-6    262 larva L3 puffstage 7-9    265 white prepupae new    256 white prepupae 12hr    405 white prepupae 24hr    497 pupae 2d postWPP    244 pupae 3d postWPP    131 pupae 4d postWPP    88 adult male 01day    105 adult male 05day    135 adult male 30day    140 adult female 01day    659 adult female 05day    1655 adult female 30day    1752 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3147 embryo 02-04hr    1400 embryo 04-06hr    1885 embryo 06-08hr    1801 embryo 08-10hr    1194 embryo 10-12hr    474 embryo 12-14hr    519 embryo 14-16hr    441 embryo 16-18hr    314 embryo 18-20hr    139 embryo 20-22hr    352 embryo 22-24hr    430 larva L1    168 larva L2    165 larva L3 12hr old    130 larva L3 puffstage 1-2    140 larva L3 puffstage 3-6    262 larva L3 puffstage 7-9    265 white prepupae new    256 white prepupae 12hr    405 white prepupae 24hr    497 pupae 2d postWPP    244 pupae 3d postWPP    131 pupae 4d postWPP    88 adult male 01day    105 adult male 05day    135 adult male 30day    140 adult female 01day    659 adult female 05day    1655 adult female 30day    1752 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0260789 expression level Developmental Stage   Expression Level embryo 00-02hr    3147 embryo 02-04hr    1400 embryo 04-06hr    1885 embryo 06-08hr    1801 embryo 08-10hr    1194 embryo 10-12hr    474 embryo 12-14hr    519 embryo 14-16hr    441 embryo 16-18hr    314 embryo 18-20hr    139 embryo 20-22hr    352 embryo 22-24hr    430 larva L1    168 larva L2    165 larva L3 12hr old    130 larva L3 puffstage 1-2    140 larva L3 puffstage 3-6    262 larva L3 puffstage 7-9    265 white prepupae new    256 white prepupae 12hr    405 white prepupae 24hr    497 pupae 2d postWPP    244 pupae 3d postWPP    131 pupae 4d postWPP    88 adult male 01day    105 adult male 05day    135 adult male 30day    140 adult female 01day    659 adult female 05day    1655 adult female 30day    1752 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3147) embryo 02-04hr  (1400) embryo 04-06hr  (1885) embryo 06-08hr  (1801) embryo 08-10hr  (1194) embryo 10-12hr  (474) embryo 12-14hr  (519) embryo 14-16hr  (441) embryo 16-18hr  (314) embryo 18-20hr  139 embryo 20-22hr  (352) embryo 22-24hr  (430) larva L1  (168) larva L2  (165) larva L3 12hr old  130 larva L3 puffstage 1-2  140 larva L3 puffstage 3-6  (262) larva L3 puffstage 7-9  (265) white prepupae new  (256) white prepupae 12hr  (405) white prepupae 24hr  (497) pupae 2d postWPP  (244) pupae 3d postWPP  131 pupae 4d postWPP    88 adult male 01day  105 adult male 05day  135 adult male 30day  140 adult female 01day  (659) adult female 05day  (1655) adult female 30day  (1752) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3147) embryo 02-04hr  1400 embryo 04-06hr  1885 embryo 06-08hr  1801 embryo 08-10hr    1194 embryo 10-12hr    474 embryo 12-14hr    519 embryo 14-16hr    441 embryo 16-18hr    314 embryo 18-20hr    139 embryo 20-22hr    352 embryo 22-24hr    430 larva L1    168 larva L2    165 larva L3 12hr old    130 larva L3 puffstage 1-2    140 larva L3 puffstage 3-6    262 larva L3 puffstage 7-9    265 white prepupae new    256 white prepupae 12hr    405 white prepupae 24hr    497 pupae 2d postWPP    244 pupae 3d postWPP    131 pupae 4d postWPP    88 adult male 01day    105 adult male 05day    135 adult male 30day    140 adult female 01day    659 adult female 05day  1655 adult female 30day  1752 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3147 embryo 02-04hr    1400 embryo 04-06hr    1885 embryo 06-08hr    1801 embryo 08-10hr    1194 embryo 10-12hr    474 embryo 12-14hr    519 embryo 14-16hr    441 embryo 16-18hr    314 embryo 18-20hr    139 embryo 20-22hr    352 embryo 22-24hr    430 larva L1    168 larva L2    165 larva L3 12hr old    130 larva L3 puffstage 1-2    140 larva L3 puffstage 3-6    262 larva L3 puffstage 7-9    265 white prepupae new    256 white prepupae 12hr    405 white prepupae 24hr    497 pupae 2d postWPP    244 pupae 3d postWPP    131 pupae 4d postWPP    88 adult male 01day    105 adult male 05day    135 adult male 30day    140 adult female 01day    659 adult female 05day    1655 adult female 30day    1752 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3147 embryo 02-04hr    1400 embryo 04-06hr    1885 embryo 06-08hr    1801 embryo 08-10hr    1194 embryo 10-12hr    474 embryo 12-14hr    519 embryo 14-16hr    441 embryo 16-18hr    314 embryo 18-20hr    139 embryo 20-22hr    352 embryo 22-24hr    430 larva L1    168 larva L2    165 larva L3 12hr old    130 larva L3 puffstage 1-2    140 larva L3 puffstage 3-6    262 larva L3 puffstage 7-9    265 white prepupae new    256 white prepupae 12hr    405 white prepupae 24hr    497 pupae 2d postWPP    244 pupae 3d postWPP    131 pupae 4d postWPP    88 adult male 01day    105 adult male 05day    135 adult male 30day    140 adult female 01day    659 adult female 05day    1655 adult female 30day    1752 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0260789    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0260789 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0260789 expression level Tissue   Expression Level Larval Central Nervous System    190.5 Larval Midgut no informative data Larval Hindgut    33.4 Larval Malpighian Tubules    28.4 Larval Fat Body no informative data Larval Salivary Gland    67.4 Larval Trachea    71.5 Larval Carcass    40.95 Adult Head    22.6 Adult Eye    22.675 Adult Brain    52.6 Adult Thoracic-Abdominal Ganglion    38.7 Adult Crop    30.3 Adult Midgut no informative data Adult Hindgut    23.5 Adult Malpighian Tubules no informative data Adult Fat Body    33.6 Adult Salivary Gland    44.3 Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    268.5 Adult Testis    18.3 Adult Male Accessory Gland    26.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    190.5 Larval Midgut no informative data Larval Hindgut    33.4 Larval Malpighian Tubules    28.4 Larval Fat Body no informative data Larval Salivary Gland    67.4 Larval Trachea    71.5 Larval Carcass    40.95 Adult Head    22.6 Adult Eye    22.675 Adult Brain    52.6 Adult Thoracic-Abdominal Ganglion    38.7 Adult Crop    30.3 Adult Midgut no informative data Adult Hindgut    23.5 Adult Malpighian Tubules no informative data Adult Fat Body    33.6 Adult Salivary Gland    44.3 Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    268.5 Adult Testis    18.3 Adult Male Accessory Gland    26.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    190.5 Larval Midgut no informative data Larval Hindgut    33.4 Larval Malpighian Tubules    28.4 Larval Fat Body no informative data Larval Salivary Gland    67.4 Larval Trachea    71.5 Larval Carcass    40.95 Adult Head    22.6 Adult Eye    22.675 Adult Brain    52.6 Adult Thoracic-Abdominal Ganglion    38.7 Adult Crop    30.3 Adult Midgut no informative data Adult Hindgut    23.5 Adult Malpighian Tubules no informative data Adult Fat Body    33.6 Adult Salivary Gland    44.3 Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    268.5 Adult Testis    18.3 Adult Male Accessory Gland    26.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    190.5 Larval Midgut no informative data Larval Hindgut    33.4 Larval Malpighian Tubules    28.4 Larval Fat Body no informative data Larval Salivary Gland    67.4 Larval Trachea    71.5 Larval Carcass    40.95 Adult Head    22.6 Adult Eye    22.675 Adult Brain    52.6 Adult Thoracic-Abdominal Ganglion    38.7 Adult Crop    30.3 Adult Midgut no informative data Adult Hindgut    23.5 Adult Malpighian Tubules no informative data Adult Fat Body    33.6 Adult Salivary Gland    44.3 Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    268.5 Adult Testis    18.3 Adult Male Accessory Gland    26.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0260789 expression level Tissue   Expression Level Larval Central Nervous System    190.5 Larval Midgut no informative data Larval Hindgut    33.4 Larval Malpighian Tubules    28.4 Larval Fat Body no informative data Larval Salivary Gland    67.4 Larval Trachea    71.5 Larval Carcass    40.95 Adult Head    22.6 Adult Eye    22.675 Adult Brain    52.6 Adult Thoracic-Abdominal Ganglion    38.7 Adult Crop    30.3 Adult Midgut no informative data Adult Hindgut    23.5 Adult Malpighian Tubules no informative data Adult Fat Body    33.6 Adult Salivary Gland    44.3 Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    268.5 Adult Testis    18.3 Adult Male Accessory Gland    26.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    190.5 Larval Midgut no informative data Larval Hindgut    33.4 Larval Malpighian Tubules    28.4 Larval Fat Body no informative data Larval Salivary Gland    67.4 Larval Trachea    71.5 Larval Carcass    40.95 Adult Head    22.6 Adult Eye    22.675 Adult Brain    52.6 Adult Thoracic-Abdominal Ganglion    38.7 Adult Crop    30.3 Adult Midgut no informative data Adult Hindgut    23.5 Adult Malpighian Tubules no informative data Adult Fat Body    33.6 Adult Salivary Gland    44.3 Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    268.5 Adult Testis    18.3 Adult Male Accessory Gland    26.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    190.5 Larval Midgut no informative data Larval Hindgut    33.4 Larval Malpighian Tubules    28.4 Larval Fat Body no informative data Larval Salivary Gland    67.4 Larval Trachea    71.5 Larval Carcass    40.95 Adult Head    22.6 Adult Eye    22.675 Adult Brain    52.6 Adult Thoracic-Abdominal Ganglion    38.7 Adult Crop    30.3 Adult Midgut no informative data Adult Hindgut    23.5 Adult Malpighian Tubules no informative data Adult Fat Body    33.6 Adult Salivary Gland    44.3 Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    268.5 Adult Testis    18.3 Adult Male Accessory Gland    26.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    190.5 Larval Midgut no informative data Larval Hindgut    33.4 Larval Malpighian Tubules    28.4 Larval Fat Body no informative data Larval Salivary Gland    67.4 Larval Trachea    71.5 Larval Carcass    40.95 Adult Head    22.6 Adult Eye    22.675 Adult Brain    52.6 Adult Thoracic-Abdominal Ganglion    38.7 Adult Crop    30.3 Adult Midgut no informative data Adult Hindgut    23.5 Adult Malpighian Tubules no informative data Adult Fat Body    33.6 Adult Salivary Gland    44.3 Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    268.5 Adult Testis    18.3 Adult Male Accessory Gland    26.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland     Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    22.6   NA  Eye    22.675   NA  Brain    52.6   190.5  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    38.7   NA  Crop    30.3   no informative data  Midgut    no informative data   33.4  Hindgut    23.5   28.4  Malpighian Tubules    no informative data   no informative data  Fat Body    33.6   67.4  Salivary Gland    44.3   NA  Heart    no informative data   71.5  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    268.5   NA  Testis    18.3   NA  Male Accessory Gland    26.2   40.95  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_13
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0260789
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele cell lethal | cell autonomous | somatic clone mxc22a-6 lethal, with Scer\GAL41407 mxcGD7494 lethal | embryonic stage | non-rescuable maternal effect | recessive mxcM1 lethal | embryonic stage | partially | recessive | rescuable maternal effect mxcM1 lethal | larval stage | recessive mxc1 mxc16a-1 mxc22a-6 mxcG48 mxcSO lethal | pharate adult stage | recessive mxcG43 lethal | pupal stage | recessive mxc1 mxc16a-1 mxcSO lethal | recessive mxc1 mxc16a-1 mxcG48 mxcM1 viable mxcG9 mxcG46 mxcM1 viable, with Scer\GAL4pnr-MD237 mxcGD7494 Sterility Allele female fertile mxcG9 female sterile mxcG46 female sterile | recessive mxc1 mxcG46 mxcM1 mxcSO male sterile mxcG46 male sterile | recessive mxcG46 sterile | recessive mxcG43 Other Phenotypes Allele neuroanatomy defective | larval stage, with Scer\GAL41407 mxcGD7494 visible mxcM1 visible, with Scer\GAL4pnr-MD237 mxcGD7494 visible | dominant | homeotic mxcG43 visible | homeotic mxcG43 mxcG46 visible | homeotic | recessive mxcM1 visible | recessive mxc1 mxcG43 mxcG46 mxcSO Phenotype manifest in Allele adult abdominal segment 4 mxc1 mxcG43 mxcG46 mxcM1 mxcSO adult head mxc22a-6 mxcSO adult mesothoracic segment mxc1 mxcG43 mxcSO antenna mxcG43 anterior lymph gland pair mxc1 arista mxc22a-6 mxcSO chaeta, with Scer\GAL4pnr-MD237 mxcGD7494 chorion mxc22a-6 mxcG46 mxcG48 mxcG9 mxcM1 crystal cell mxc1 mxc16a-1 dorsal appendage mxc22a-6 mxcG46 mxcG48 mxcG9 mxcM1 egg mxc22a-6 mxcG46 mxcG48 mxcG9 mxcM1 egg chamber mxc1 mxc16a-1 mxc22a-6 mxcG43 mxcG46 mxcG48 mxcG9 mxcM1 mxcSO embryonic/first instar larval cuticle | dorsal mxcM1 embryonic/larval central nervous system mxc1 embryonic/larval digestive system mxc22a-6 embryonic/larval fat body mxc1 embryonic/larval hemocyte mxc1 mxc16a-1 mxcG43 embryonic/larval hemolymph mxc1 embryonic/larval hindgut | embryonic stage mxc22a-6 embryonic/larval lymph gland mxc1 mxc16a-1 mxcG43 mxcG46 embryonic/larval midgut mxc1 embryonic/larval neuroblast | larval stage, with Scer\GAL41407 mxcGD7494 embryonic head mxcM1 embryonic segment mxcM1 eye mxc1 mxc22a-6 mxcG43 mxcG46 mxcSO eye-antennal disc mxc1 mxc16a-1 ganglion mother cell | larval stage, with Scer\GAL41407 mxcGD7494 genital disc mxc1 mxc16a-1 gonad | female mxcG43 gonad | larval stage mxc1 haltere disc mxc1 mxc16a-1 hindgut imaginal ring mxc22a-6 imaginal disc mxc1 mxc16a-1 mxc22a-6 mxcG48 imaginal disc | larval stage mxc1 lamellocyte mxc1 mxc16a-1 mxcG43 leg mxc1 mxcG43 mxcSO male accessory gland mxcG43 mxcG46 mxcM1 maxillary palpus mxc22a-6 mxcSO melanotic mass mxc1 mxc16a-1 mxc22a-6 mxcG48 mxcM1 mxcSO mesothoracic leg mxcG43 mesothoracic tergum, with Scer\GAL4pnr-MD237 mxcGD7494 metathoracic leg mxcG43 pigment cell mxcG48 plasmatocyte mxc1 podocyte mxc1 mxc16a-1 mxcG43 prohemocyte mxc1 prothoracic leg disc mxc16a-1 sex comb mxcG43 sex comb | ectopic mxcM1 testis mxcG43 mxcG46 mxcM1 third segment of antenna mxc22a-6 mxcSO trichogen cell, with Scer\GAL4pnr-MD237 mxcGD7494 unguis mxcG43 ventral thoracic disc mxc1 mxc16a-1 wing mxc1 mxcG43 mxcSO wing disc mxc1 mxc16a-1
Classical Alleles ( 10 )
For All Classical Alleles Show
Allele of mxc Class Mutagen Stocks Known lesion mxc1 ethyl methanesulfonate 3 -- mxcG48 amorphic allele - genetic evidence ethyl methanesulfonate 1 Yes mxc16a-1 gamma ray 1 Yes mxc22a-6 gamma ray 1 Yes mxcG43 ethyl methanesulfonate 1 Yes mxcG46 hypomorphic allele - genetic evidence ethyl methanesulfonate 1 Yes mxcSO 1 -- mxc2 0 -- mxcG9 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- mxcM1 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mxc Class Mutagen Stocks Known lesion mxcGD7494 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mxcHMS00444 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mxcJF01992 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mxcUbi.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Duplicated in	Dp(1;4)A17 (Docquier et al., 1996) Dp(1;4)mxc+R (Umea Stock Center, 2001.6) Dp(1;Y)FF1 (Santamaria and Randsholt, 1995, Docquier et al., 1996) Dp(1;Y)lz+ (Santamaria and Randsholt, 1995)
Disrupted in	Df(1)10-70d (Santamaria and Randsholt, 1995, Docquier et al., 1996)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{TRiP.HMS00444} NA characterization construct PBac{Ubi-GFP-mxc} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
hemocyte differentiation inferred from mutant phenotype (Remillieux-Leschelle et al., 2002) hemocyte proliferation inferred from mutant phenotype (Remillieux-Leschelle et al., 2002) lateral inhibition inferred from mutant phenotype (Mummery-Widmer et al., 2009) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component
CV term Evidence References
histone locus body inferred from direct assay (White et al., 2011)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
DNA binding inferred from electronic annotation with InterPro:IPR017956 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
hemopoiesis traceable author statement (Evans et al., 2003)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mxc allele Gene References mxcG43 dom (Ruhf et al., 2001) dpp (Saget et al., 1998) Tl (Remillieux-Leschelle et al., 2002) tub (Remillieux-Leschelle et al., 2002) z (Santamaria and Randsholt, 1995) mxcG46 Dfd (Saget et al., 1998) hh (Randsholt et al., 2000) z (Santamaria and Randsholt, 1995) mxcG48 z (Santamaria and Randsholt, 1995) mxcM1 Asx (Saget et al., 1998) corto (Lopez et al., 2001) Dfd (Saget et al., 1998) E(z) (Docquier et al., 1996, Saget et al., 1998) Pc (Docquier et al., 1996, Saget et al., 1998) Pcl (Docquier et al., 1996, Saget et al., 1998) pho (Saget et al., 1998) Psc (Docquier et al., 1996, Saget et al., 1998) Scm (Docquier et al., 1996, Saget et al., 1998) sxc (Saget et al., 1998) unspecified ash1 (Gildea et al., 2000) trx (Gildea et al., 2000)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58321 DroID - A comprehensive database of gene and protein interactions. • FBgn0260789 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31869
Orthologs
Genome-wide drosophilid orthologs	Dana\GF19096 Dana\GF19208 Dere\GG18304 Dere\GG18988 Dgri\GH12028 Dgri\GH12701 Dmoj\GI14301 Dper\GL18292 Dpse\GA11366 Dpse\GA11418 Dsec\GM22338 Dsec\GM22404 Dsim\GD24774 Dvir\GJ18801 Dvir\GJ19358 Dwil\GK25140 Dwil\GK25794 Dyak\GE15461 Dyak\GE17783
Curated drosophilid orthologs	Dpse\GA11418
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL002319-PA Aedes aegypti (mosquito) XP_001945819.1 Acyrthosiphon pisum (pea aphid) CPIJ009934 Culex pipens (mosquito) ENSP00000278612 Homo sapiens (human) 175286 Lottia gigantea (owl limpet) ENSMUSP00000048709 Mus musculus (house mouse) ENSPPYP00000004401 Pongo pygmaeus (orangutan) ENSPTRP00000007310 Pan troglodytes (chimpanzee) ENSRNOP00000047149 Rattus norvegicus (norway rat) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0233037 FBgn0227753 FBgn0205949 FBgn0177208 FBgn0249494 FBgn0155884 FBgn0120180 FBgn0111194 FBgn0096107 CPIJ009934 AGAP000588 AAEL002319
Stocks & Reagents
Stocks Listed in FlyBase ( 12 )
Bloomington	32114 w1 mxcG46/FM7a 32183 w1 mxcG43/FM7c 7141 y1 ac1 mxcG48/FM7a 6360 w1 mxc1; Dp(1;4)mxc+R 32446 y1 sc* v1; P{TRiP.HMS00444}attP2 25970 y1 v1; P{TRiP.JF01992}attP2/TM3, Sb1 7128 y1 cv1 mxc22a-6 v1 f1 car1/FM7c 7133 y1 cv1 mxc16a-1 v1 f1 car1/FM7a
Kyoto	101105 In(1)FM7 / mxc1 101107 In(1)FM7 / y1 mxcSO 108753 w1 mxc1; Dp(1;4)mxc+R
VDRC	v42978 w1118; P{GD7494}v42978
Genomic Clones ( 1 )
	BACR30C13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 18 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD32107
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD23314 LD47188 RH13511 RH45019 RH60279 RH66709 SD19086 SD22526
Other clones	191941 214571.10 Dmel_dig_015164_0610_1285 Dmel_dig_015946_0661_1273 DMG1-chrX.10.024.a EK010603 EK174708 EK294858 LD47288
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0260789 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31869
Antibody Information
	polyclonal (White et al., 2011)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: mxc CG12124 (Randsholt, 2009.1.22)
Additional comments	The mxc locus was previously reported to correspond to the CG12058 annotation, based on rescue data, which could not be repeated. Molecular data from 4 different mxc alleles indicates that the CG12058 annotation is unaffected in the mxc mutants, but that the coding sequence of the adjacent gene, CG12124, is affected in all 4 cases. Thus, mxc corresponds to the CG12124 annotation. (Randsholt, 2009.1.22) The mxc locus was previously reported to correspond to the CG12058 annotation, but this was found to be an error (see FBrf0206617). The CG12058 annotation has thus been split out into a separate gene from mxc in release 5.16 of the genome annotation and has been renamed "CG42569" to avoid confusion. (FlyBase Genome Annotators, 2008) FlyBase curator comment: FBrf0129198 states that mxc corresponds to the CG12058 annotation, but this was later found to be an error (see FBrf0206617). (Lasko, 2000.6.8)
Other Comments
	Candidate gene for cyst presence/absence quantitative trait locus. (Macdonald and Goldstein, 1999) A Pc-group gene. Besides the common homeotic transformations characteristic of Pc-group mutants, mxc mutants zygotically mimic the maternal effect mutants of the posterior group. Loss of normal mxc function can promote uncontrolled malignant growth which indicates a possible relationship between Pc-group genes and tumor suppressor genes. (Santamaria and Randsholt, 1995) Mutants display a blood cell neoplastic phenotype. (Mechler, 1994)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132320 RefSeq (Proteins) • NP_572548 DDBJ / EMBL / GenBank • AA951543 AAF46472 Entrez Gene - A searchable database of RefSeq genes. • 31869 UniProtKB/TrEMBL • Q9W363
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • LisH dimerisation motif (IPR006594) AT hook, DNA-binding motif (IPR017956)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58321 DroID - A comprehensive database of gene and protein interactions. • FBgn0260789 DRSC - Results from RNAi screens. • FBgn0260789 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0260789 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0260789 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31869 InParanoid A subset of ortholog calls from InParanoid. • AAEL002319-PA Aedes aegypti (mosquito) XP_001945819.1 Acyrthosiphon pisum (pea aphid) CPIJ009934 Culex pipens (mosquito) ENSP00000278612 Homo sapiens (human) 175286 Lottia gigantea (owl limpet) ENSMUSP00000048709 Mus musculus (house mouse) ENSPPYP00000004401 Pongo pygmaeus (orangutan) ENSPTRP00000007310 Pan troglodytes (chimpanzee) ENSRNOP00000047149 Rattus norvegicus (norway rat) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31869 modMine - Data generated by the modENCODE project. • FBgn0260789 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0233037 FBgn0227753 FBgn0205949 FBgn0177208 FBgn0249494 FBgn0155884 FBgn0120180 FBgn0111194 FBgn0096107 CPIJ009934 AGAP000588 AAEL002319
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG12058   CG12124 (White et al., 2011, Randsholt, 2009.1.22, Perkins et al., 1.15.2009, Ni et al., 2010.12.1) l(1)mbn (Kondo, 1998, Gateff, 1998, Gateff, 1994, Shrestha and Gateff, 1982, Loffler et al., 1990, Gateff and Mechler, 1989, Gateff, 1978, ) mxc (White et al., 2011, Randsholt, 2009.1.22, Lasko, 2000.6.8, Minakhina and Steward, 2006, Hill-Burns and Clark, 2009, Neumüller et al., 2011)
Name Synonym	CG12124   lethal(1)malignant blood neoplasm   multi sex combs (Hill-Burns and Clark, 2009)
Secondary FlyBase IDs
	FBgn0001798 FBgn0005639 FBgn0030112 FBgn0030113
References ( 53 )
Generate a list of	All references relating to this gene ( 53 )
List References by type	Research paper  ( 17 ) Supplementary material  ( 4 ) Review  ( 15 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 5 ) FlyBase analysis  ( 2 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 2 )
	Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] White et al., 2011, J. Cell Biol. 193(4): 677--694 Drosophila histone locus bodies form by hierarchical recruitment of components. [FBrf0213662] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...