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FB2025_04
,
released October 2, 2025
l(1)mbn, MPM2, MPM-2
chromatin factor involved in assembly of histone locus body, an essential histone mRNA processing factor, hemocyte proliferation and differentiation
Please see the JBrowse view of Dmel\mxc for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.52
Low-frequency RNA-Seq exon junction(s) not annotated.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mxc using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
JBrowse - Visual display of RNA-Seq signals
View Dmel\mxc in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Candidate gene for cyst presence/absence quantitative trait locus.
A Pc-group gene. Besides the common homeotic transformations characteristic of Pc-group mutants, mxc mutants zygotically mimic the maternal effect mutants of the posterior group. Loss of normal mxc function can promote uncontrolled malignant growth which indicates a possible relationship between Pc-group genes and tumor suppressor genes.
Mutants display a blood cell neoplastic phenotype.
Source for merge of: mxc CG12124
The mxc locus was previously reported to correspond to the CG12058 annotation, based on rescue data, which could not be repeated. Molecular data from 4 different mxc alleles indicates that the CG12058 annotation is unaffected in the mxc mutants, but that the coding sequence of the adjacent gene, CG12124, is affected in all 4 cases. Thus, mxc corresponds to the CG12124 annotation.
The mxc locus was previously reported to correspond to the CG12058 annotation, but this was found to be an error (see FBrf0206617). The CG12058 annotation has thus been split out into a separate gene from mxc in release 5.16 of the genome annotation and has been renamed "CG42569" to avoid confusion.
FlyBase curator comment: FBrf0129198 states that mxc corresponds to the CG12058 annotation, but this was later found to be an error (see FBrf0206617).
