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Gene Dmel\ctrip

General Information
Symbol	Dmel\ctrip	Species	D. melanogaster
Name	circadian trip	Annotation symbol	CG42574
Feature type	protein_coding_gene	FlyBase ID	FBgn0260794
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	CG17735, CG14656
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	82D5-82D6	Sequence location	3R:612,767..637,788 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene circadian trip is referred to in FlyBase by the symbol Dmel\ctrip (CG42574, FBgn0260794). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ligand-dependent nuclear receptor binding. There is experimental evidence that it is involved in the biological process: regulation of circadian rhythm; neurogenesis. 13 alleles are reported. No phenotypic data is available. It has 8 annotated transcripts and 8 annotated polypeptides. Protein features are: Armadillo-like helical; Armadillo-type fold; HECT; WWE domain; WWE domain, subgroup. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 06-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, inseminated spermatheca, adult male reproductive system, larval/adult carcass. Gene sequence location is 3R:612767..637788.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Controlled Vocabulary Terms regulation of circadian rhythm Insertions P{GSV6}GS11430 Alleles ctrip[NIG.14656R3] ctrip[19F1] ctrip[NIG.17735R3] ctrip[GS11430] Sequence features HFA12242 HFA12287 BKN45298 BKN31565 BKN20611 References Lamaze et al., 2011, EMBO Rep. 12(6): 549--557
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 82D5-82D6   Limits computationally determined from genome sequence between P{PZ}l(3)0273302733 and P{EP}EP974
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\ctrip for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	gene_with_dicistronic_primary_transcript ; SO:0000721 Shares 5' UTR with upstream gene. Gene merge based on EST/cDNA data.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) ctrip-RA FBtr0301437  NM_141239   10417   3140 ctrip-RB FBtr0303911  NM_001202241   10557   3140 ctrip-RC FBtr0303912  NM_001202242   9208   2737 ctrip-RD FBtr0303913  NM_001202243   10576   2561 ctrip-RE FBtr0303914  NM_001202244   9927   2930 ctrip-RF FBtr0303915  NM_001202245   10414   3139 ctrip-RG FBtr0303916  NM_001202246   11226   2561 ctrip-RH FBtr0303917  NM_001202247   9343   2737
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein ctrip-PA   FBpp0290652   336.6   3140   7.26     NP_649496   AAF52092 ctrip-PB   FBpp0292914   336.6   3140   7.26     NP_001189170   ADV37262 ctrip-PC   FBpp0292915   292.5   2737   6.72     NP_001189171   ADV37263 ctrip-PD   FBpp0292916   275.6   2561   7.66     NP_001189172   ADV37264 ctrip-PE   FBpp0292917   314.2   2930   6.99     NP_001189173   ADV37265 ctrip-PF   FBpp0292918   336.5   3139   7.26     NP_001189174   ADV37266 ctrip-PG   FBpp0292919   275.6   2561   7.66     NP_001189175   ADV37267 ctrip-PH   FBpp0292920   292.5   2737   6.72     NP_001189176   ADV37268
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • WWE domain, subgroup (IPR018123) HECT (IPR000569) WWE domain (IPR004170) Armadillo-like helical (IPR011989) Armadillo-type fold (IPR016024)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140744   AA440201   AA567625   AE014297 AAF52092   AE014297 ADV37262   AE014297 ADV37263   AE014297 ADV37264   AE014297 ADV37265   AE014297 ADV37266   AE014297 ADV37267   AE014297 ADV37268   AI297184   AI532895   AI946289   AW942003   AY061045   BE975323   BG632967   BG639698   BI354595   BI617438   BI622320   BP557015   BP557016   BT011134   BT058083   BT100224   CK135555   CK659559   CO178838   CO183494   CO185906   CO186034   CO186748   CO265695   CO272714   CO278719   CO280778   CO280792   CO281025   CO281238   CO283041   CO283671   CO284753   CO285733   CO287612   CO288165   CO299556   CO301115   CO305906   CO305993   CO309432   CO313568   CO315847   CO319435   CO321010   CO322529   CO323316   CO326218   CO326254   CO326619   CO328389   CO329711   CO333828   CO339137   CO340332   EC057431   EC061656   EC061902   EC062638   EC064395   EC065278   EC065677   EC071884   EC072000   EC077885   EC080226   EC083304   EC084104   EC084792   EC198981   EC199830   EC200136   EC201921   EC202696   EC205420   EC210729   EC217581   EC217845   EC218784   EC222904   EC227301   EC227801   EC235032   EC235039   EC237948   EC237984   EC240615   EC240737   EC243368   EC244710   EC245144   EC252762   EC253065   EC254423   EC257038   EC258914   EC259008   EC259996   EV582435   EY198843   EY198983   GH957236   GH981084
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VN58
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0260794    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0260794 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 06-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0260794 expression level Developmental Stage   Expression Level embryo 00-02hr    6148 embryo 02-04hr    3892 embryo 04-06hr    7367 embryo 06-08hr    10136 embryo 08-10hr    8446 embryo 10-12hr    4491 embryo 12-14hr    5717 embryo 14-16hr    5459 embryo 16-18hr    5162 embryo 18-20hr    4488 embryo 20-22hr    2392 embryo 22-24hr    2377 larva L1    1616 larva L2    1314 larva L3 12hr old    1458 larva L3 puffstage 1-2    1203 larva L3 puffstage 3-6    3612 larva L3 puffstage 7-9    4472 white prepupae new    4417 white prepupae 12hr    3543 white prepupae 24hr    5274 pupae 2d postWPP    4361 pupae 3d postWPP    3748 pupae 4d postWPP    3354 adult male 01day    4882 adult male 05day    6084 adult male 30day    5786 adult female 01day    3240 adult female 05day    4847 adult female 30day    4745 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6148) embryo 02-04hr  (3892) embryo 04-06hr  (7367) embryo 06-08hr  (10136) embryo 08-10hr  (8446) embryo 10-12hr  (4491) embryo 12-14hr  (5717) embryo 14-16hr  (5459) embryo 16-18hr  (5162) embryo 18-20hr  (4488) embryo 20-22hr  (2392) embryo 22-24hr  (2377) larva L1  (1616) larva L2  (1314) larva L3 12hr old  (1458) larva L3 puffstage 1-2  (1203) larva L3 puffstage 3-6  (3612) larva L3 puffstage 7-9  (4472) white prepupae new  (4417) white prepupae 12hr  (3543) white prepupae 24hr  (5274) pupae 2d postWPP  (4361) pupae 3d postWPP  (3748) pupae 4d postWPP  (3354) adult male 01day  (4882) adult male 05day  (6084) adult male 30day  (5786) adult female 01day  (3240) adult female 05day  (4847) adult female 30day  (4745) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6148) embryo 02-04hr  (3892) embryo 04-06hr  (7367) embryo 06-08hr  (10136) embryo 08-10hr  (8446) embryo 10-12hr  (4491) embryo 12-14hr  (5717) embryo 14-16hr  (5459) embryo 16-18hr  (5162) embryo 18-20hr  (4488) embryo 20-22hr  (2392) embryo 22-24hr  (2377) larva L1  (1616) larva L2    1314 larva L3 12hr old  1458 larva L3 puffstage 1-2    1203 larva L3 puffstage 3-6  (3612) larva L3 puffstage 7-9  (4472) white prepupae new  (4417) white prepupae 12hr  (3543) white prepupae 24hr  (5274) pupae 2d postWPP  (4361) pupae 3d postWPP  (3748) pupae 4d postWPP  (3354) adult male 01day  (4882) adult male 05day  (6084) adult male 30day  (5786) adult female 01day  (3240) adult female 05day  (4847) adult female 30day  (4745) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6148 embryo 02-04hr    3892 embryo 04-06hr    7367 embryo 06-08hr  10136 embryo 08-10hr    8446 embryo 10-12hr    4491 embryo 12-14hr    5717 embryo 14-16hr    5459 embryo 16-18hr    5162 embryo 18-20hr    4488 embryo 20-22hr    2392 embryo 22-24hr    2377 larva L1    1616 larva L2    1314 larva L3 12hr old    1458 larva L3 puffstage 1-2    1203 larva L3 puffstage 3-6    3612 larva L3 puffstage 7-9    4472 white prepupae new    4417 white prepupae 12hr    3543 white prepupae 24hr    5274 pupae 2d postWPP    4361 pupae 3d postWPP    3748 pupae 4d postWPP    3354 adult male 01day    4882 adult male 05day    6084 adult male 30day    5786 adult female 01day    3240 adult female 05day    4847 adult female 30day    4745 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6148 embryo 02-04hr    3892 embryo 04-06hr    7367 embryo 06-08hr    10136 embryo 08-10hr    8446 embryo 10-12hr    4491 embryo 12-14hr    5717 embryo 14-16hr    5459 embryo 16-18hr    5162 embryo 18-20hr    4488 embryo 20-22hr    2392 embryo 22-24hr    2377 larva L1    1616 larva L2    1314 larva L3 12hr old    1458 larva L3 puffstage 1-2    1203 larva L3 puffstage 3-6    3612 larva L3 puffstage 7-9    4472 white prepupae new    4417 white prepupae 12hr    3543 white prepupae 24hr    5274 pupae 2d postWPP    4361 pupae 3d postWPP    3748 pupae 4d postWPP    3354 adult male 01day    4882 adult male 05day    6084 adult male 30day    5786 adult female 01day    3240 adult female 05day    4847 adult female 30day    4745 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0260794 expression level Developmental Stage   Expression Level embryo 00-02hr    6148 embryo 02-04hr    3892 embryo 04-06hr    7367 embryo 06-08hr    10136 embryo 08-10hr    8446 embryo 10-12hr    4491 embryo 12-14hr    5717 embryo 14-16hr    5459 embryo 16-18hr    5162 embryo 18-20hr    4488 embryo 20-22hr    2392 embryo 22-24hr    2377 larva L1    1616 larva L2    1314 larva L3 12hr old    1458 larva L3 puffstage 1-2    1203 larva L3 puffstage 3-6    3612 larva L3 puffstage 7-9    4472 white prepupae new    4417 white prepupae 12hr    3543 white prepupae 24hr    5274 pupae 2d postWPP    4361 pupae 3d postWPP    3748 pupae 4d postWPP    3354 adult male 01day    4882 adult male 05day    6084 adult male 30day    5786 adult female 01day    3240 adult female 05day    4847 adult female 30day    4745 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6148) embryo 02-04hr  (3892) embryo 04-06hr  (7367) embryo 06-08hr  (10136) embryo 08-10hr  (8446) embryo 10-12hr  (4491) embryo 12-14hr  (5717) embryo 14-16hr  (5459) embryo 16-18hr  (5162) embryo 18-20hr  (4488) embryo 20-22hr  (2392) embryo 22-24hr  (2377) larva L1  (1616) larva L2  (1314) larva L3 12hr old  (1458) larva L3 puffstage 1-2  (1203) larva L3 puffstage 3-6  (3612) larva L3 puffstage 7-9  (4472) white prepupae new  (4417) white prepupae 12hr  (3543) white prepupae 24hr  (5274) pupae 2d postWPP  (4361) pupae 3d postWPP  (3748) pupae 4d postWPP  (3354) adult male 01day  (4882) adult male 05day  (6084) adult male 30day  (5786) adult female 01day  (3240) adult female 05day  (4847) adult female 30day  (4745) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6148) embryo 02-04hr  (3892) embryo 04-06hr  (7367) embryo 06-08hr  (10136) embryo 08-10hr  (8446) embryo 10-12hr  (4491) embryo 12-14hr  (5717) embryo 14-16hr  (5459) embryo 16-18hr  (5162) embryo 18-20hr  (4488) embryo 20-22hr  2392 embryo 22-24hr  2377 larva L1  1616 larva L2    1314 larva L3 12hr old  1458 larva L3 puffstage 1-2    1203 larva L3 puffstage 3-6  (3612) larva L3 puffstage 7-9  (4472) white prepupae new  (4417) white prepupae 12hr  (3543) white prepupae 24hr  (5274) pupae 2d postWPP  (4361) pupae 3d postWPP  (3748) pupae 4d postWPP  (3354) adult male 01day  (4882) adult male 05day  (6084) adult male 30day  (5786) adult female 01day  (3240) adult female 05day  (4847) adult female 30day  (4745) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6148 embryo 02-04hr    3892 embryo 04-06hr    7367 embryo 06-08hr  10136 embryo 08-10hr    8446 embryo 10-12hr    4491 embryo 12-14hr    5717 embryo 14-16hr    5459 embryo 16-18hr    5162 embryo 18-20hr    4488 embryo 20-22hr    2392 embryo 22-24hr    2377 larva L1    1616 larva L2    1314 larva L3 12hr old    1458 larva L3 puffstage 1-2    1203 larva L3 puffstage 3-6    3612 larva L3 puffstage 7-9    4472 white prepupae new    4417 white prepupae 12hr    3543 white prepupae 24hr    5274 pupae 2d postWPP    4361 pupae 3d postWPP    3748 pupae 4d postWPP    3354 adult male 01day    4882 adult male 05day    6084 adult male 30day    5786 adult female 01day    3240 adult female 05day    4847 adult female 30day    4745 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6148 embryo 02-04hr    3892 embryo 04-06hr    7367 embryo 06-08hr    10136 embryo 08-10hr    8446 embryo 10-12hr    4491 embryo 12-14hr    5717 embryo 14-16hr    5459 embryo 16-18hr    5162 embryo 18-20hr    4488 embryo 20-22hr    2392 embryo 22-24hr    2377 larva L1    1616 larva L2    1314 larva L3 12hr old    1458 larva L3 puffstage 1-2    1203 larva L3 puffstage 3-6    3612 larva L3 puffstage 7-9    4472 white prepupae new    4417 white prepupae 12hr    3543 white prepupae 24hr    5274 pupae 2d postWPP    4361 pupae 3d postWPP    3748 pupae 4d postWPP    3354 adult male 01day    4882 adult male 05day    6084 adult male 30day    5786 adult female 01day    3240 adult female 05day    4847 adult female 30day    4745 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0260794    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0260794 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, inseminated spermatheca, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_27
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0260794
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal ctripCA06996 lethal, with Scer\GAL41407 ctripGD16533 lethal, with Scer\GAL4pnr-MD237 ctripGD16533 lethal | pupal stage, with Scer\GAL4pnr-MD237 ctripGD8394 viable ctrip19F1 viable, with Scer\GAL4pnr-MD237 ctripGD9454 Other Phenotypes Allele circadian rhythm defective, with Scer\GAL4P2.4.Pdf ctripNIG.14656R3 ctripNIG.17735R3 circadian rhythm defective, with Scer\GAL4P2.4.Pdf, ctripNIG.14656R3 ctripNIG.17735R3 circadian rhythm defective, with Scer\GAL4P2.4.Pdf, ctripNIG.17735R3 ctripNIG.14656R3 circadian rhythm defective, with Scer\GAL4tim.PE ctripNIG.14656R3 ctripNIG.17735R3 circadian rhythm defective, with Scer\GAL4tim.PE, ctripNIG.14656R3 ctripNIG.17735R3 circadian rhythm defective, with Scer\GAL4tim.PE, ctripNIG.17735R3 ctripNIG.14656R3 locomotor rhythm defective, with Scer\GAL4tim.PE ctripmiRNA.Scer\UAS neuroanatomy defective | larval stage, with Scer\GAL41407 ctripGD16533 Phenotype manifest in Allele embryonic/larval neuroblast | larval stage, with Scer\GAL41407 ctripGD16533 ganglion mother cell | larval stage, with Scer\GAL41407 ctripGD16533
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of ctrip Class Mutagen Stocks Known lesion ctripG19129 P-element activity 1 -- ctripHP35916 1 -- ctrip19F1 P-element activity 0 Yes ctripCA06996 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of ctrip Class Mutagen Stocks Known lesion ctripGD16533 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes ctripGD8394 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ctripGD9454 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ctripHMS00322 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ctripKK100515 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ctripGS11430 in vitro construct - regulatory fusion 0 -- ctripmiRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes ctripNIG.14656R3 in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes ctripNIG.17735R3 in vitro construct - regulatory fusion in vitro construct - RNAi 0 --
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6142 (Ryder, 2004.4.26)
Partially disrupted in	DF(3R)1501 (Lamaze et al., 2011)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}ctripG19129 NA P{EP}EP3416 NA P{EPg}ctripHP35916 NA P{GSV6}GS11430 NA miscellaneous insertions P{PTT-GA}ctripCA06996 NA P{UAST-YFP.CG9807.T21N}03 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) regulation of circadian rhythm inferred from mutant phenotype (Lamaze et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
acid-amino acid ligase activity inferred from electronic annotation with InterPro:IPR000569 (FlyBase Curators et al., 2004-) ligand-dependent nuclear receptor binding inferred from sequence or structural similarity with UniProtKB:Q14669 (FlyBase, 1992-) zinc ion binding inferred from electronic annotation with InterPro:IPR018123 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
protein modification process inferred from electronic annotation with InterPro:IPR000569 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
intracellular inferred from electronic annotation with InterPro:IPR000569 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions ctrip allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65812 DroID - A comprehensive database of gene and protein interactions. • FBgn0260794 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40596
Orthologs
Genome-wide drosophilid orthologs	Dana\GF16087 Dana\GF16088 Dere\GG11355 Dere\GG11366 Dgri\GH17429 Dgri\GH17440 Dmoj\GI22511 Dmoj\GI22512 Dper\GL22220 Dpse\GA30193 Dsec\GM10678 Dsec\GM10679 Dsim\GD19653 Dsim\GD19654 Dvir\GJ10114 Dvir\GJ10115 Dwil\GK14423 Dwil\GK14424 Dyak\GE25329 Dyak\GE25331
Curated drosophilid orthologs	Dpse\GA13151   Dpse\GA30193
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12475 NV13195 LH11940 FBgn0242410 FBgn0216430 FBgn0197403 FBgn0191145 FBgn0165625 JGI_V11_50916 FBgn0074659 FBgn0159812 FBgn0145239 FBgn0124899 FBgn0103666 FBgn0093110 CPIJ012813 CPIJ012812 BGIBMGA007539 ACYPI009777 GB12788 AGAP001296 AAEL017357 PHUM075960 GLEAN_10408
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	21989 w1118; P{EPg}ctripHP35916 33435 y1 sc* v1; P{TRiP.HMS00322}attP2 31840 w1118; P{EP}ctripG19129/TM6C, Sb1
VDRC	v108546 P{KK100515}VIE-260B v18304 w1118 P{GD8394}v18304 v48052 w1118; P{GD16533}v48052 v48117 w1118; P{GD16533}v48117 v50189 w1118; P{GD9454}v50189/TM3
Genomic Clones ( 2 )
	BACR02C19 BACR11M01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 101 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	HL01545 LD01463
Other clones	MIP04713 MIP09720
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH17383 GM27550 LD14818 LP11431 LP17404 RH47774
Other clones	9145 9529 11340 17988 33150 34393 37488 39281 40478 41513 41653 52085 54389 56516 56528 62842 62947 82325 83597 107182 107568 121544 146892 147471 159935 173913 190951 214215.62 214223.51 214279.71 214283.68 214385.60 214437.4 214501.59 282387 bs23b02 bs41d04 CK01.13B.F4 CK01.14C.E7 CK01.22D.D7 CK01.22D.G12 CK01.25D.E9 CK01.30C.G4 CK01.77C.B2 CK01.145D.H1 CK00433 Dmel_dig_005973_0615_2240 DMG2-chr3R.1.072.a.1 DMG2-chr3R.1.073.a.1 EC25825 EK014254 EK015317 EK022719 EK057703 EK060537 EK066309 EK067902 EK108123 EK131325 EK143416 EK154834 EK154860 EK155749 EK156251 EK162105 EK164043 EK166711 EK175808 EK180147 EK188322 EK190154 EK217559 EK233446 EK249655 EK249952 EK262744 EK278120 EK290130 EK293551 EK308118 EP00933 EP03451 EP03525 EP04324 EP09124 EP10436 FGM306H01 RH54166 RP004063105 RP004234001 SD04541
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0260794 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40596 40597
Antibody Information
Other Information
Discoverer
Etymology
	Source for identity of: ctrip CG42574 (Lamaze et al., 2011)
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG17735 CG14656 (FlyBase Genome Annotators, 2008)
Additional comments	Annotations CG17735 and CG14656 merged as CG42574 in release 5.16 of the genome annotation. (FlyBase Genome Annotators, 2008)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141239 NM_001202241 NM_001202242 NM_001202243 NM_001202244 NM_001202245 NM_001202246 NM_001202247 RefSeq (Proteins) • NP_649496 NP_001189170 NP_001189171 NP_001189172 NP_001189173 NP_001189174 NP_001189175 NP_001189176 DDBJ / EMBL / GenBank • AA567625 AAF52092 ADV37262 ADV37263 ADV37264 ADV37265 ADV37266 ADV37267 ADV37268 AW942003 Entrez Gene - A searchable database of RefSeq genes. • 40596 UniProtKB/TrEMBL • Q9VN58
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • WWE domain, subgroup (IPR018123) HECT (IPR000569) WWE domain (IPR004170) Armadillo-like helical (IPR011989) Armadillo-type fold (IPR016024)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65812 DroID - A comprehensive database of gene and protein interactions. • FBgn0260794 DRSC - Results from RNAi screens. • FBgn0260794 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0260794 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0260794 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40596 40597 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40596 modMine - Data generated by the modENCODE project. • FBgn0260794 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12475 NV13195 LH11940 FBgn0242410 FBgn0216430 FBgn0197403 FBgn0191145 FBgn0165625 JGI_V11_50916 FBgn0074659 FBgn0159812 FBgn0145239 FBgn0124899 FBgn0103666 FBgn0093110 CPIJ012813 CPIJ012812 BGIBMGA007539 ACYPI009777 GB12788 AGAP001296 AAEL017357 PHUM075960 GLEAN_10408
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	CG14656 (Buszczak et al., 2007, Zhang et al., 2007) CG17735 (Hoopfer et al., 2008, Sathyanarayanan et al., 2008, Peschel et al., 2009, Keleman et al., 2009.8.5, Ni et al., 2010.12.1, Lamaze et al., 2011) CG42574 (Lamaze et al., 2011, FlyBase Genome Annotators, 2008, ) ctrip (Lamaze et al., 2011)
Name Synonym	CG14656   CG17735   circadian trip (Lamaze et al., 2011, )
Secondary FlyBase IDs
	FBgn0037277 FBgn0037278
References ( 24 )
Generate a list of	All references relating to this gene ( 24 )
List References by type	Research paper  ( 5 ) Supplementary material  ( 5 ) Review  ( 1 ) Personal communication to FlyBase  ( 8 ) FlyBase analysis  ( 2 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 1 )
	Lamaze et al., 2011, EMBO Rep. 12(6): 549--557 The E3 ubiquitin ligase CTRIP controls CLOCK levels and PERIOD oscillations in Drosophila. [FBrf0213851] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...