• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\ctrip

General Information
Symbol	Dmel\ctrip	Species	D. melanogaster
Name	circadian trip	Annotation symbol	CG42574
Feature type	protein_coding_gene	FlyBase ID	FBgn0260794
Gene Model Status	Current	Stock availability	9 publicly available
Also Known As	CG17735, CG14656
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	82D5-82D6	Sequence location	3R:612,006..637,788 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene circadian trip is referred to in FlyBase by the symbol Dmel\ctrip (CG42574, FBgn0260794). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ligand-dependent nuclear receptor binding. There is experimental evidence that it is involved in the biological process: regulation of circadian rhythm; neurogenesis. 14 alleles are reported. No phenotypic data is available. It has 8 annotated transcripts and 8 annotated polypeptides. Protein features are: Armadillo-like helical; Armadillo-type fold; HECT; WWE domain; WWE domain, subgroup. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 06-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, inseminated spermatheca, adult male reproductive system, larval/adult carcass. Gene sequence location is 3R:612006..637788.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 82D5-82D6   Limits computationally determined from genome sequence between P{PZ}l(3)0273302733 and P{EP}EP974
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\ctrip for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47 Annotated transcripts do not represent all supported alternative splices within 5' UTR. Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Shares 5' UTR with upstream gene. Gene merge based on EST/cDNA data.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) ctrip-RA FBtr0301437  NM_141239   10417   3140 ctrip-RB FBtr0303911  NM_001202241   10557   3140 ctrip-RC FBtr0303912  NM_001202242   9208   2737 ctrip-RE FBtr0303914  NM_001202244   9927   2930 ctrip-RF FBtr0303915  NM_001202245   10553   3139 ctrip-RH FBtr0303917  NM_001202247   9343   2737 ctrip-RI FBtr0334902  NM_001202243   10101   2736 ctrip-RJ FBtr0334903  NM_001202246   10685   2929
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein ctrip-PA   FBpp0290652   336.6   3140   7.26     NP_649496   AAF52092 ctrip-PB   FBpp0292914   336.6   3140   7.26     NP_001189170   ADV37262 ctrip-PC   FBpp0292915   292.5   2737   6.72     NP_001189171   ADV37263 ctrip-PE   FBpp0292917   314.2   2930   6.99     NP_001189173   ADV37265 ctrip-PF   FBpp0292918   336.5   3139   7.26     NP_001189174   ADV37266 ctrip-PH   FBpp0292920   292.5   2737   6.72     NP_001189176   ADV37268 ctrip-PI   FBpp0306923   292.4   2736   6.72     NP_001189172   ADV37264 ctrip-PJ   FBpp0306924   314.1   2929   6.99     NP_001189175   ADV37267
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • WWE domain, subgroup (IPR018123) HECT (IPR000569) WWE domain (IPR004170) Armadillo-like helical (IPR011989) Armadillo-type fold (IPR016024)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140744   AA140745   AA440201   AA567625   AE014297 AAF52092   AE014297 ADV37262   AE014297 ADV37263   AE014297 ADV37264   AE014297 ADV37265   AE014297 ADV37266   AE014297 ADV37267   AE014297 ADV37268   AI297184   AI532895   AI946289   AW942003   AY061045   BE975323   BG632967   BG639698   BI354595   BI617438   BI622320   BP557015   BP557016   BT011134   BT058083   BT100224   CK135555   CK659559   CO154843   CO178838   CO183494   CO185906   CO186034   CO186748   CO265695   CO272714   CO278719   CO280778   CO280792   CO281025   CO281238   CO283041   CO283671   CO284473   CO284506   CO284753   CO285733   CO287612   CO288165   CO297883   CO299134   CO299556   CO301115   CO305906   CO305993   CO309432   CO313568   CO315847   CO319435   CO321010   CO322529   CO323316   CO326218   CO326254   CO326619   CO328389   CO329273   CO329711   CO333828   CO339137   CO340332   CO343892   EC057431   EC061656   EC061902   EC062638   EC064395   EC065278   EC065677   EC071884   EC072000   EC077885   EC080226   EC080518   EC083304   EC084104   EC084792   EC090181   EC198981   EC199830   EC200136   EC201921   EC202696   EC205420   EC210729   EC217581   EC217845   EC218784   EC222828   EC222904   EC227301   EC227801   EC235032   EC235039   EC237948   EC237984   EC240615   EC240737   EC243368   EC244710   EC245144   EC252762   EC253065   EC254423   EC257038   EC258914   EC259008   EC259996   EC262866   EV579727   EV582435   EY198843   EY198983   GH957236   GH981084
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VN58
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, inseminated spermatheca, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    76 central nervous system, larvae L3    68 central nervous system, pupae P8    37 head, virgin 1-day female    19 head, virgin 4-day female    15 head, virgin 20-day female    15 head, mated 1-day female    17 head, mated 4-day female    15 head, mated 20-day female    15 head, mated 1-day male    28 head, mated 4-day male    23 head, mated 20-day male    23 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    27 digestive system, 1-day adult    12 digestive system, 4-day adult    17 digestive system, 20-day adult    17 fat body, larvae L3 wandering    16 fat body, white prepupae    38 fat body, pupae P8    16 carcass, larvae L3 wandering    51 carcass, 1-day adult    17 carcass, 4-day adult    17 carcass, 20-day adult    15 ovary, virgin 4-day female    81 ovary, mated 4-day female    81 testis, mated 4-day male    76 accessory gland, mated 4-day male    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (76) central nervous system, larvae L3  (68) central nervous system, pupae P8  (37) head, virgin 1-day female    19 head, virgin 4-day female    15 head, virgin 20-day female    15 head, mated 1-day female    17 head, mated 4-day female    15 head, mated 20-day female    15 head, mated 1-day male  (28) head, mated 4-day male    23 head, mated 20-day male    23 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    15 digestive system, larvae L3 wandering  (27) digestive system, 1-day adult    12 digestive system, 4-day adult    17 digestive system, 20-day adult    17 fat body, larvae L3 wandering    16 fat body, white prepupae  (38) fat body, pupae P8    16 carcass, larvae L3 wandering  (51) carcass, 1-day adult    17 carcass, 4-day adult    17 carcass, 20-day adult    15 ovary, virgin 4-day female  (81) ovary, mated 4-day female  (81) testis, mated 4-day male  (76) accessory gland, mated 4-day male    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    76 central nervous system, larvae L3    68 central nervous system, pupae P8    37 head, virgin 1-day female    19 head, virgin 4-day female    15 head, virgin 20-day female    15 head, mated 1-day female    17 head, mated 4-day female    15 head, mated 20-day female    15 head, mated 1-day male    28 head, mated 4-day male    23 head, mated 20-day male    23 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    27 digestive system, 1-day adult    12 digestive system, 4-day adult    17 digestive system, 20-day adult    17 fat body, larvae L3 wandering    16 fat body, white prepupae    38 fat body, pupae P8    16 carcass, larvae L3 wandering    51 carcass, 1-day adult    17 carcass, 4-day adult    17 carcass, 20-day adult    15 ovary, virgin 4-day female    81 ovary, mated 4-day female    81 testis, mated 4-day male    76 accessory gland, mated 4-day male    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    76 central nervous system, larvae L3    68 central nervous system, pupae P8    37 head, virgin 1-day female    19 head, virgin 4-day female    15 head, virgin 20-day female    15 head, mated 1-day female    17 head, mated 4-day female    15 head, mated 20-day female    15 head, mated 1-day male    28 head, mated 4-day male    23 head, mated 20-day male    23 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    27 digestive system, 1-day adult    12 digestive system, 4-day adult    17 digestive system, 20-day adult    17 fat body, larvae L3 wandering    16 fat body, white prepupae    38 fat body, pupae P8    16 carcass, larvae L3 wandering    51 carcass, 1-day adult    17 carcass, 4-day adult    17 carcass, 20-day adult    15 ovary, virgin 4-day female    81 ovary, mated 4-day female    81 testis, mated 4-day male    76 accessory gland, mated 4-day male    19 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    76 central nervous system, larvae L3    68 central nervous system, pupae P8    37 head, virgin 1-day female    19 head, virgin 4-day female    15 head, virgin 20-day female    15 head, mated 1-day female    17 head, mated 4-day female    15 head, mated 20-day female    15 head, mated 1-day male    28 head, mated 4-day male    23 head, mated 20-day male    23 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    27 digestive system, 1-day adult    12 digestive system, 4-day adult    17 digestive system, 20-day adult    17 fat body, larvae L3 wandering    16 fat body, white prepupae    38 fat body, pupae P8    16 carcass, larvae L3 wandering    51 carcass, 1-day adult    17 carcass, 4-day adult    17 carcass, 20-day adult    15 ovary, virgin 4-day female    81 ovary, mated 4-day female    81 testis, mated 4-day male    76 accessory gland, mated 4-day male    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (76) central nervous system, larvae L3  (68) central nervous system, pupae P8  (37) head, virgin 1-day female    19 head, virgin 4-day female    15 head, virgin 20-day female    15 head, mated 1-day female    17 head, mated 4-day female    15 head, mated 20-day female    15 head, mated 1-day male  28 head, mated 4-day male    23 head, mated 20-day male    23 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    15 digestive system, larvae L3 wandering  27 digestive system, 1-day adult    12 digestive system, 4-day adult    17 digestive system, 20-day adult    17 fat body, larvae L3 wandering    16 fat body, white prepupae  (38) fat body, pupae P8    16 carcass, larvae L3 wandering  (51) carcass, 1-day adult    17 carcass, 4-day adult    17 carcass, 20-day adult    15 ovary, virgin 4-day female  (81) ovary, mated 4-day female  (81) testis, mated 4-day male  (76) accessory gland, mated 4-day male    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    76 central nervous system, larvae L3    68 central nervous system, pupae P8    37 head, virgin 1-day female    19 head, virgin 4-day female    15 head, virgin 20-day female    15 head, mated 1-day female    17 head, mated 4-day female    15 head, mated 20-day female    15 head, mated 1-day male    28 head, mated 4-day male    23 head, mated 20-day male    23 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    27 digestive system, 1-day adult    12 digestive system, 4-day adult    17 digestive system, 20-day adult    17 fat body, larvae L3 wandering    16 fat body, white prepupae    38 fat body, pupae P8    16 carcass, larvae L3 wandering    51 carcass, 1-day adult    17 carcass, 4-day adult    17 carcass, 20-day adult    15 ovary, virgin 4-day female    81 ovary, mated 4-day female    81 testis, mated 4-day male    76 accessory gland, mated 4-day male    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    76 central nervous system, larvae L3    68 central nervous system, pupae P8    37 head, virgin 1-day female    19 head, virgin 4-day female    15 head, virgin 20-day female    15 head, mated 1-day female    17 head, mated 4-day female    15 head, mated 20-day female    15 head, mated 1-day male    28 head, mated 4-day male    23 head, mated 20-day male    23 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    27 digestive system, 1-day adult    12 digestive system, 4-day adult    17 digestive system, 20-day adult    17 fat body, larvae L3 wandering    16 fat body, white prepupae    38 fat body, pupae P8    16 carcass, larvae L3 wandering    51 carcass, 1-day adult    17 carcass, 4-day adult    17 carcass, 20-day adult    15 ovary, virgin 4-day female    81 ovary, mated 4-day female    81 testis, mated 4-day male    76 accessory gland, mated 4-day male    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 06-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    74 embryo 02-04hr    47 embryo 04-06hr    89 embryo 06-08hr    122 embryo 08-10hr    102 embryo 10-12hr    54 embryo 12-14hr    69 embryo 14-16hr    65 embryo 16-18hr    62 embryo 18-20hr    54 embryo 20-22hr    29 embryo 22-24hr    29 larva L1    19 larva L2    16 larva L3 12hr old    18 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    43 larva L3 puffstage 7-9    54 white prepupae new    53 white prepupae 12hr    43 white prepupae 24hr    64 pupae 2d postWPP    52 pupae 3d postWPP    45 pupae 4d postWPP    40 adult male 01day    58 adult male 05day    73 adult male 30day    69 adult female 01day    39 adult female 05day    58 adult female 30day    57 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (74) embryo 02-04hr  (47) embryo 04-06hr  (89) embryo 06-08hr  (122) embryo 08-10hr  (102) embryo 10-12hr  (54) embryo 12-14hr  (69) embryo 14-16hr  (65) embryo 16-18hr  (62) embryo 18-20hr  (54) embryo 20-22hr  (29) embryo 22-24hr  (29) larva L1    19 larva L2    16 larva L3 12hr old    18 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6  (43) larva L3 puffstage 7-9  (54) white prepupae new  (53) white prepupae 12hr  (43) white prepupae 24hr  (64) pupae 2d postWPP  (52) pupae 3d postWPP  (45) pupae 4d postWPP  (40) adult male 01day  (58) adult male 05day  (73) adult male 30day  (69) adult female 01day  (39) adult female 05day  (58) adult female 30day  (57) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    74 embryo 02-04hr    47 embryo 04-06hr    89 embryo 06-08hr  (122) embryo 08-10hr  102 embryo 10-12hr    54 embryo 12-14hr    69 embryo 14-16hr    65 embryo 16-18hr    62 embryo 18-20hr    54 embryo 20-22hr    29 embryo 22-24hr    29 larva L1    19 larva L2    16 larva L3 12hr old    18 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    43 larva L3 puffstage 7-9    54 white prepupae new    53 white prepupae 12hr    43 white prepupae 24hr    64 pupae 2d postWPP    52 pupae 3d postWPP    45 pupae 4d postWPP    40 adult male 01day    58 adult male 05day    73 adult male 30day    69 adult female 01day    39 adult female 05day    58 adult female 30day    57 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    74 embryo 02-04hr    47 embryo 04-06hr    89 embryo 06-08hr    122 embryo 08-10hr    102 embryo 10-12hr    54 embryo 12-14hr    69 embryo 14-16hr    65 embryo 16-18hr    62 embryo 18-20hr    54 embryo 20-22hr    29 embryo 22-24hr    29 larva L1    19 larva L2    16 larva L3 12hr old    18 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    43 larva L3 puffstage 7-9    54 white prepupae new    53 white prepupae 12hr    43 white prepupae 24hr    64 pupae 2d postWPP    52 pupae 3d postWPP    45 pupae 4d postWPP    40 adult male 01day    58 adult male 05day    73 adult male 30day    69 adult female 01day    39 adult female 05day    58 adult female 30day    57 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    74 embryo 02-04hr    47 embryo 04-06hr    89 embryo 06-08hr    122 embryo 08-10hr    102 embryo 10-12hr    54 embryo 12-14hr    69 embryo 14-16hr    65 embryo 16-18hr    62 embryo 18-20hr    54 embryo 20-22hr    29 embryo 22-24hr    29 larva L1    19 larva L2    16 larva L3 12hr old    18 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    43 larva L3 puffstage 7-9    54 white prepupae new    53 white prepupae 12hr    43 white prepupae 24hr    64 pupae 2d postWPP    52 pupae 3d postWPP    45 pupae 4d postWPP    40 adult male 01day    58 adult male 05day    73 adult male 30day    69 adult female 01day    39 adult female 05day    58 adult female 30day    57 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (74) embryo 02-04hr  (47) embryo 04-06hr  (89) embryo 06-08hr  (122) embryo 08-10hr  (102) embryo 10-12hr  (54) embryo 12-14hr  (69) embryo 14-16hr  (65) embryo 16-18hr  (62) embryo 18-20hr  (54) embryo 20-22hr  29 embryo 22-24hr  29 larva L1    19 larva L2    16 larva L3 12hr old    18 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6  (43) larva L3 puffstage 7-9  (54) white prepupae new  (53) white prepupae 12hr  (43) white prepupae 24hr  (64) pupae 2d postWPP  (52) pupae 3d postWPP  (45) pupae 4d postWPP  (40) adult male 01day  (58) adult male 05day  (73) adult male 30day  (69) adult female 01day  (39) adult female 05day  (58) adult female 30day  (57) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    74 embryo 02-04hr    47 embryo 04-06hr    89 embryo 06-08hr  122 embryo 08-10hr  102 embryo 10-12hr    54 embryo 12-14hr    69 embryo 14-16hr    65 embryo 16-18hr    62 embryo 18-20hr    54 embryo 20-22hr    29 embryo 22-24hr    29 larva L1    19 larva L2    16 larva L3 12hr old    18 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    43 larva L3 puffstage 7-9    54 white prepupae new    53 white prepupae 12hr    43 white prepupae 24hr    64 pupae 2d postWPP    52 pupae 3d postWPP    45 pupae 4d postWPP    40 adult male 01day    58 adult male 05day    73 adult male 30day    69 adult female 01day    39 adult female 05day    58 adult female 30day    57 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    74 embryo 02-04hr    47 embryo 04-06hr    89 embryo 06-08hr    122 embryo 08-10hr    102 embryo 10-12hr    54 embryo 12-14hr    69 embryo 14-16hr    65 embryo 16-18hr    62 embryo 18-20hr    54 embryo 20-22hr    29 embryo 22-24hr    29 larva L1    19 larva L2    16 larva L3 12hr old    18 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    43 larva L3 puffstage 7-9    54 white prepupae new    53 white prepupae 12hr    43 white prepupae 24hr    64 pupae 2d postWPP    52 pupae 3d postWPP    45 pupae 4d postWPP    40 adult male 01day    58 adult male 05day    73 adult male 30day    69 adult female 01day    39 adult female 05day    58 adult female 30day    57 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    16 embryonic 1182-4H    46 embryonic GM2    40 embryonic Kc167    29 embryonic S1    39 embryonic S3    21 leg disc CME L1    17 wing disc CME-W2    28 wing disc ML-DmD8    27 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    29 wing disc ML-DmD21    6 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    38 eye-antennal disc ML-DmD11    26 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    32 CNS ML-DmBG2-c2    31 tumorous blood cells mbn2    28 ovary fGS/OSS    51 ovary OSC    59 ovary OSS    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (27) Schneider line 2 Sg4    16 embryonic 1182-4H  (46) embryonic GM2  (40) embryonic Kc167  (29) embryonic S1  (39) embryonic S3    21 leg disc CME L1    17 wing disc CME-W2  (28) wing disc ML-DmD8  (27) wing disc ML-DmD9    24 wing disc ML-DmD16-c3  (29) wing disc ML-DmD21    6 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3  (38) eye-antennal disc ML-DmD11  26 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1  (32) CNS ML-DmBG2-c2  (31) tumorous blood cells mbn2  (28) ovary fGS/OSS  (51) ovary OSC  (59) ovary OSS  (37) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    16 embryonic 1182-4H    46 embryonic GM2    40 embryonic Kc167    29 embryonic S1    39 embryonic S3    21 leg disc CME L1    17 wing disc CME-W2    28 wing disc ML-DmD8    27 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    29 wing disc ML-DmD21    6 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    38 eye-antennal disc ML-DmD11    26 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    32 CNS ML-DmBG2-c2    31 tumorous blood cells mbn2    28 ovary fGS/OSS    51 ovary OSC    59 ovary OSS    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    16 embryonic 1182-4H    46 embryonic GM2    40 embryonic Kc167    29 embryonic S1    39 embryonic S3    21 leg disc CME L1    17 wing disc CME-W2    28 wing disc ML-DmD8    27 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    29 wing disc ML-DmD21    6 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    38 eye-antennal disc ML-DmD11    26 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    32 CNS ML-DmBG2-c2    31 tumorous blood cells mbn2    28 ovary fGS/OSS    51 ovary OSC    59 ovary OSS    37 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    16 embryonic 1182-4H    46 embryonic GM2    40 embryonic Kc167    29 embryonic S1    39 embryonic S3    21 leg disc CME L1    17 wing disc CME-W2    28 wing disc ML-DmD8    27 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    29 wing disc ML-DmD21    6 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    38 eye-antennal disc ML-DmD11    26 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    32 CNS ML-DmBG2-c2    31 tumorous blood cells mbn2    28 ovary fGS/OSS    51 ovary OSC    59 ovary OSS    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  27 Schneider line 2 Sg4    16 embryonic 1182-4H  (46) embryonic GM2  (40) embryonic Kc167  29 embryonic S1  (39) embryonic S3    21 leg disc CME L1    17 wing disc CME-W2  28 wing disc ML-DmD8  27 wing disc ML-DmD9    24 wing disc ML-DmD16-c3  29 wing disc ML-DmD21    6 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3  (38) eye-antennal disc ML-DmD11  26 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1  32 CNS ML-DmBG2-c2  31 tumorous blood cells mbn2  28 ovary fGS/OSS  (51) ovary OSC  (59) ovary OSS  (37) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    16 embryonic 1182-4H    46 embryonic GM2    40 embryonic Kc167    29 embryonic S1    39 embryonic S3    21 leg disc CME L1    17 wing disc CME-W2    28 wing disc ML-DmD8    27 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    29 wing disc ML-DmD21    6 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    38 eye-antennal disc ML-DmD11    26 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    32 CNS ML-DmBG2-c2    31 tumorous blood cells mbn2    28 ovary fGS/OSS    51 ovary OSC    59 ovary OSS    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    16 embryonic 1182-4H    46 embryonic GM2    40 embryonic Kc167    29 embryonic S1    39 embryonic S3    21 leg disc CME L1    17 wing disc CME-W2    28 wing disc ML-DmD8    27 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    29 wing disc ML-DmD21    6 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    38 eye-antennal disc ML-DmD11    26 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    32 CNS ML-DmBG2-c2    31 tumorous blood cells mbn2    28 ovary fGS/OSS    51 ovary OSC    59 ovary OSS    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    43 cold shock, 4-day adult    33 heat shock, 4-day adult    32 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    34 Cadmium 100 mM 48 hrs, 4-day adult    68 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    38 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    80 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    51 Caffeine 25 mg/ml 48 hrs, 4-day adult    39 Paraquat 5 mM 48 hrs, 4-day adult    56 Paraquat 10 mM 48 hrs, 4-day adult    65 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (43) cold shock, 4-day adult  (33) heat shock, 4-day adult  (32) Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult  (34) Cadmium 100 mM 48 hrs, 4-day adult  (68) Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult  (38) Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult  (31) Ethanol 2.5% 3 hrs, larvae L3  (80) Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (51) Caffeine 25 mg/ml 48 hrs, 4-day adult  (39) Paraquat 5 mM 48 hrs, 4-day adult  (56) Paraquat 10 mM 48 hrs, 4-day adult  (65) Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    43 cold shock, 4-day adult    33 heat shock, 4-day adult    32 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    34 Cadmium 100 mM 48 hrs, 4-day adult    68 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    38 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    80 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    51 Caffeine 25 mg/ml 48 hrs, 4-day adult    39 Paraquat 5 mM 48 hrs, 4-day adult    56 Paraquat 10 mM 48 hrs, 4-day adult    65 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    43 cold shock, 4-day adult    33 heat shock, 4-day adult    32 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    34 Cadmium 100 mM 48 hrs, 4-day adult    68 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    38 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    80 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    51 Caffeine 25 mg/ml 48 hrs, 4-day adult    39 Paraquat 5 mM 48 hrs, 4-day adult    56 Paraquat 10 mM 48 hrs, 4-day adult    65 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    43 cold shock, 4-day adult    33 heat shock, 4-day adult    32 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    34 Cadmium 100 mM 48 hrs, 4-day adult    68 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    38 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    80 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    51 Caffeine 25 mg/ml 48 hrs, 4-day adult    39 Paraquat 5 mM 48 hrs, 4-day adult    56 Paraquat 10 mM 48 hrs, 4-day adult    65 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (43) cold shock, 4-day adult  (33) heat shock, 4-day adult  32 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult  (34) Cadmium 100 mM 48 hrs, 4-day adult  (68) Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult  (38) Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult  31 Ethanol 2.5% 3 hrs, larvae L3  (80) Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (51) Caffeine 25 mg/ml 48 hrs, 4-day adult  (39) Paraquat 5 mM 48 hrs, 4-day adult  (56) Paraquat 10 mM 48 hrs, 4-day adult  (65) Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    43 cold shock, 4-day adult    33 heat shock, 4-day adult    32 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    34 Cadmium 100 mM 48 hrs, 4-day adult    68 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    38 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    80 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    51 Caffeine 25 mg/ml 48 hrs, 4-day adult    39 Paraquat 5 mM 48 hrs, 4-day adult    56 Paraquat 10 mM 48 hrs, 4-day adult    65 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    43 cold shock, 4-day adult    33 heat shock, 4-day adult    32 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    34 Cadmium 100 mM 48 hrs, 4-day adult    68 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    38 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    80 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    51 Caffeine 25 mg/ml 48 hrs, 4-day adult    39 Paraquat 5 mM 48 hrs, 4-day adult    56 Paraquat 10 mM 48 hrs, 4-day adult    65 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_27 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • HL01545 LD01463 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0260794
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal ctripCA06996 ctripGD16533 lethal, with Scer\GAL4pnr-MD237 ctripGD16533 lethal | pupal stage, with Scer\GAL4pnr-MD237 ctripGD8394 viable ctrip19F1 viable, with Scer\GAL4pnr-MD237 ctripGD9454 Other Phenotypes Allele circadian rhythm defective, with Scer\GAL4P2.4.Pdf ctripNIG.14656R ctripNIG.17735R circadian rhythm defective, with Scer\GAL4P2.4.Pdf, ctripNIG.14656R ctripNIG.17735R circadian rhythm defective, with Scer\GAL4P2.4.Pdf, ctripNIG.17735R ctripNIG.14656R circadian rhythm defective, with Scer\GAL4tim.PE ctripNIG.14656R ctripNIG.17735R circadian rhythm defective, with Scer\GAL4tim.PE, ctripNIG.14656R ctripNIG.17735R circadian rhythm defective, with Scer\GAL4tim.PE, ctripNIG.17735R ctripNIG.14656R locomotor rhythm defective, with Scer\GAL4tim.PE ctripmiRNA.Scer\UAS neuroanatomy defective | larval stage ctripGD16533 Phenotype manifest in Allele embryonic/larval neuroblast | larval stage ctripGD16533 ganglion mother cell | larval stage ctripGD16533
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of ctrip Class Mutagen Stocks Known lesion ctripG19129 P-element activity 1 -- ctripHP35916 1 -- ctripMI03169 1 -- ctrip19F1 P-element activity 0 Yes ctripCA06996 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of ctrip Class Mutagen Stocks Known lesion ctripGD16533 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes ctripGD8394 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ctripGD9454 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ctripHMS00322 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ctripKK100515 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ctripGS11430 in vitro construct - regulatory fusion 0 -- ctripmiRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes ctripNIG.14656R in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes ctripNIG.17735R in vitro construct - regulatory fusion in vitro construct - RNAi 0 --
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6142 (Ryder, 2004.4.26)
Partially disrupted in	DF(3R)1501 (Lamaze et al., 2011)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data characterization construct P{NIG.14656R} NA P{NIG.17735R} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}ctripG19129 NA P{EP}EP3416 NA P{EPg}ctripHP35916 NA P{GSV6}GS11430 NA miscellaneous insertions Mi{MIC}ctripMI03169 NA P{PTT-GA}ctripCA06996 NA P{UAST-YFP.CG9807.T21N}03 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) regulation of circadian rhythm inferred from mutant phenotype (Lamaze et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
ligand-dependent nuclear receptor binding inferred from sequence or structural similarity with UniProtKB:Q14669 (FlyBase, 1992-) ubiquitin-protein ligase activity inferred from electronic annotation with InterPro:IPR000569 (FlyBase Curators et al., 2004-) zinc ion binding inferred from electronic annotation with InterPro:IPR018123 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
cellular protein modification process inferred from electronic annotation with InterPro:IPR000569 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
intracellular inferred from electronic annotation with InterPro:IPR000569 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	gene_with_edited_transcript (Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions ctrip allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65812 DroID - A comprehensive database of gene and protein interactions. • FBgn0260794 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40596
Orthologs
OrthoDB Orthologs (45) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG647GCN Dipteran inclusive ortholog search EOG61VK9Z Insect inclusive ortholog search EOG6XKT2W Arthropod inclusive ortholog search EOG6BNZSN Metazoa inclusive ortholog search EOG6XQ37K
Orthologs in Drosophila Species (EOG647GCN)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\ctrip     Drosophila simulans   Dsim\GD19654 Y   Drosophila simulans   Dsim\GD22439     Drosophila simulans   Dsim\GD16266     Drosophila sechellia   Dsec\GM10679 Y   Drosophila sechellia   Dsec\GM18547     Drosophila erecta   Dere\GG11366 Y   Drosophila yakuba   Dyak\GE19990     Drosophila yakuba   Dyak\GE25331 Y   Drosophila ananassae   Dana\GF23446     Drosophila ananassae   Dana\GF16088 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA30193 Y   Drosophila persimilis   Dper\GL15022     Drosophila persimilis   Dper\GL22220 Y   Drosophila willistoni   Dwil\GK14424 Y   Drosophila virilis   Dvir\GJ10115 Y   Drosophila mojavensis   Dmoj\GI22511 Y   Drosophila grimshawi   Dgri\GH17429 Y
Orthologs in non-Drosophila Dipterans (EOG61VK9Z)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL017357   Anopheles gambiae Malaria mosquito  Agam\AGAP001296   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012812   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012813
Orthologs in non-Dipteran Insects (EOG6XKT2W)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC409382   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006926   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH27267   Atta cephalotes Leafcutter ant  Acep\ACEP17813   Camponotus floridanus Florida carpenter ant  Cflo\CFLO26989   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22036   Linepithema humile Argentine ant  Lhum\LH11940   Pogonomyrmex barbatus Red harvester ant  Pbar\PB12475   Solenopsis invicta Red fire ant  Sinv\SINV21437   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009777   Bombyx mori Silkmoth  Bmor\BGIBMGA007539   Pediculus humanus Human body louse  Phum\PHUM075960   Tribolium castaneum Red flour beetle  Tcas\TC010408
Orthologs in non-Insect Arthropods (EOG6BNZSN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Irx4
Orthologs in non-Arthropod Metazoa (EOG6XQ37K)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002508gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016715gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003857gn   Danio rerio Zebrafish  Drer\si:ch211-272f3.4   Xenopus tropicalis Western clawed frog  Xtro\trip12   Gallus gallus Domestic chicken  Ggal\TRIP12   Mus musculus House mouse  Mmus\Trip12   Rattus norvegicus Norway rat  Rnor\Trip12   Homo sapiens Human  Hsap\TRIP12
Human Orthologs (1)
Gene OMIM HGNC Hsap\TRIP12
AAA Orthologs (20) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD19653 Drosophila simulans Dsim\GD19654 Drosophila sechellia Dsec\GM10678 Drosophila sechellia Dsec\GM10679 Drosophila erecta Dere\GG11355 Drosophila erecta Dere\GG11366 Drosophila yakuba Dyak\GE25329 Drosophila yakuba Dyak\GE25331 Drosophila ananassae Dana\GF16087 Drosophila ananassae Dana\GF16088 Drosophila pseudoobscura pseudoobscura Dpse\GA30193 Drosophila persimilis Dper\GL22220 Drosophila willistoni Dwil\GK14423 Drosophila willistoni Dwil\GK14424 Drosophila virilis Dvir\GJ10114 Drosophila virilis Dvir\GJ10115 Drosophila mojavensis Dmoj\GI22511 Drosophila mojavensis Dmoj\GI22512 Drosophila grimshawi Dgri\GH17429 Drosophila grimshawi Dgri\GH17440
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	21989 w1118; P{EPg}ctripHP35916 33435 y1 sc* v1; P{TRiP.HMS00322}attP2 31840 w1118; P{EP}ctripG19129/TM6C, Sb1 41385 y1 w*; Mi{MIC}ctripMI03169/TM3, Sb1 Ser1
VDRC	v108546 P{KK100515}VIE-260B v18304 w1118 P{GD8394}v18304 v48052 w1118; P{GD16533}v48052 v48117 w1118; P{GD16533}v48117 v50189 w1118; P{GD9454}v50189/TM3
Genomic Clones ( 2 )
	BACR02C19 BACR11M01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 113 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	HL01545 LD01463
Other clones	MIP04713 MIP09720
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH17383 GM27550 LD14818 LP11431 LP17404 RH47774
Other clones	9145 9529 11340 17988 33150 34393 37488 39281 40478 41513 41653 52085 53364 54389 56516 56528 62842 62947 82325 83597 107182 107568 121544 146892 147471 159935 173913 190249 190951 214215.62 214223.51 214279.71 214283.68 214385.60 214437.4 214501.59 282387 524175 bs23b02 bs41d04 CK01.13B.F4 CK01.14C.E7 CK01.22D.D7 CK01.22D.G12 CK01.25D.E9 CK01.30C.G4 CK01.36A.D10 CK01.77C.B2 CK01.145D.H1 CK00433 Dmel_dig_005973_0615_2240 Dmel_dig_009837_0654_1067 DMG2-chr3R.1.072.a.1 DMG2-chr3R.1.073.a.1 EC25825 EK014254 EK015317 EK022719 EK057703 EK060537 EK066309 EK067902 EK108123 EK131325 EK143416 EK154834 EK154860 EK155749 EK156251 EK162105 EK164043 EK166138 EK166209 EK166711 EK170826 EK174612 EK175808 EK180147 EK188322 EK190154 EK217559 EK233446 EK249655 EK249952 EK262744 EK278120 EK290130 EK292411 EK293551 EK308118 EN04914 EP00933 EP03451 EP03525 EP04324 EP09124 EP10436 EP18313 FGM306H01 RH54166 RP004063105 RP004234001 SD04541
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0260794 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40596
Antibody Information
Other Information
Discoverer
Etymology
	Source for identity of: ctrip CG42574 (Lamaze et al., 2011)
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG17735 CG14656 (FlyBase Genome Annotators, 2008)
Additional comments	Annotations CG17735 and CG14656 merged as CG42574 in release 5.16 of the genome annotation. (FlyBase Genome Annotators, 2008)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141239 NM_001202241 NM_001202242 NM_001202243 NM_001202244 NM_001202245 NM_001202246 NM_001202247 RefSeq (Proteins) • NP_649496 NP_001189170 NP_001189171 NP_001189172 NP_001189173 NP_001189174 NP_001189175 NP_001189176 DDBJ / EMBL / GenBank • AA567625 AAF52092 ADV37262 ADV37263 ADV37264 ADV37265 ADV37266 ADV37267 ADV37268 AW942003 Entrez Gene - A searchable database of RefSeq genes. • 40596 UniProtKB/TrEMBL • Q9VN58
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • WWE domain, subgroup (IPR018123) HECT (IPR000569) WWE domain (IPR004170) Armadillo-like helical (IPR011989) Armadillo-type fold (IPR016024) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • HL01545 LD01463
Linkouts
	BioGRID - A database of protein and genetic interactions • 65812 DroID - A comprehensive database of gene and protein interactions. • FBgn0260794 DRSC - Results from RNAi screens. • FBgn0260794 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0260794 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0260794 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40596 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40596 modMine - Data generated by the modENCODE project. • FBgn0260794
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	CG14656 (Buszczak et al., 2007, Zhang et al., 2007, Yano et al., 2012) CG17735 (Hoopfer et al., 2008, Sathyanarayanan et al., 2008, Peschel et al., 2009, Keleman et al., 2009.8.5, Ni et al., 2010.12.1, Lamaze et al., 2011) CG42574 (Lamaze et al., 2011, FlyBase Genome Annotators, 2008, ) ctrip (Lamaze et al., 2011)
Name Synonym	CG14656   CG17735   circadian trip (Lamaze et al., 2011, )
Secondary FlyBase IDs
	FBgn0037277 FBgn0037278
References ( 31 )
Generate a list of	All references relating to this gene ( 31 )
List References by type	Research paper  ( 7 ) Supplementary material  ( 7 ) Review  ( 1 ) Personal communication to FlyBase  ( 10 ) FlyBase analysis  ( 3 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 3 )
	Fisher et al., 2012, BMC Genomics 13: 506 Advances in genome-wide RNAi cellular screens: a case study using the Drosophila JAK/STAT pathway. [FBrf0220361] Yano et al., 2012, J. Neurogenet. 26(1): 53--63 Identification of proteasome components required for apical localization of chaoptin using functional genomics. [FBrf0217843] Lamaze et al., 2011, EMBO Rep. 12(6): 549--557 The E3 ubiquitin ligase CTRIP controls CLOCK levels and PERIOD oscillations in Drosophila. [FBrf0213851] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...