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Gene Dmel\Gprk1

General Information
Symbol	Dmel\Gprk1	Species	D. melanogaster
Name	G protein-coupled receptor kinase 1	Annotation symbol	CG40129
Feature type	protein_coding_gene	FlyBase ID	FBgn0260798
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	RK, Gprk-1
Genomic Location
Chromosome (arm)	2R	Recombination map	2-[55.1]
Cytogenetic map	41B3-41C2	Sequence location	2R:209,942..358,573 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene G protein-coupled receptor kinase 1 is referred to in FlyBase by the symbol Dmel\Gprk1 (CG40129, FBgn0260798). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: G-protein coupled receptor binding; ATP binding; phosphatidylinositol binding; rhodopsin kinase activity. There is experimental evidence that it is involved in the biological process: protein phosphorylation; imaginal disc-derived wing vein specification; phototransduction, visible light; metarhodopsin inactivation. 7 alleles are reported. The phenotype of these alleles is annotated with: wing. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: AGC-kinase, C-terminal; GPCR kinase; Pleckstrin homology domain; Pleckstrin homology-type; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Regulator of G protein signalling; Regulator of G protein signalling superfamily; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase, catalytic domain; Serine/threonine-protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 and 12-24 hour embryonic stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1630514_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Gprk1. Gene sequence location is 2R:209942..358573.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Controlled Vocabulary Terms termination of G-protein coupled receptor signaling pathway
FB2012_01	Sequence features BKN50787 HFA20732 BKN51199 BKN40510 HFA20916
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 41B3-41C2   Left limit from in situ hybridisation (FBrf0054946) Right limit from in situ hybridisation (FBrf0054946)
Experimentally Determined Cytological Location
Cytogenetic map Notes References 41B3-41C2     (Drosophila Heterochromatin Genome Project, 2004) 41B3-41C2   (determined by in situ hybridisation)   (Cassill et al., 1991)
Experimentally Determined Recombination Data
Location	2-[55.1]
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Gprk1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Gprk1-RA FBtr0111121  NM_001042973   2385   700 Gprk1-RB FBtr0302242  NM_001169580   2285   700
Additional Transcript Data & Comments
Reported size (kB)	2.3 (longest cDNA) (Cassill et al., 1991)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Gprk1-PA   FBpp0110413   80.6   700   6.58     NP_001036438   EAA46156 Gprk1-PB   FBpp0291451   80.6   700   6.58     NP_001163051   ACZ94331
Additional Polypeptide Data & Comments
Reported size (kDa)	700 (aa); 80 (kD predicted) (Cassill et al., 1991)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • GPCR kinase (IPR000239) Regulator of G protein signalling (IPR000342) Protein kinase, catalytic domain (IPR000719) AGC-kinase, C-terminal (IPR000961) Pleckstrin homology domain (IPR001849) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Pleckstrin homology-type (IPR011993) Regulator of G protein signalling superfamily (IPR016137) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140883   AA141122   AA141519   AA141731   AA142147   AA265001   AA390357   AA539249   AABU01002711 EAA46156   AE013599 ACZ94331   AF171865   AI257619   BG637922   BG639612   BI164724   BI168045   BI168590   BI170341   BI172790   BI173489   BI212293   BI212305   BI214120   BI214352   BI216188   BI239961   BI241838   BI242899   BI243105   BI356570   BI356934   BI357455   BI361854   BI369363   BI369864   BI370964   BI373094   BI375605   BI483116   BI484537   BI563870   BI564872   BI565814   BI566006   BI569870   BI571025   BI571915   BI572060   BI572498   BI572698   BI572705   BI572981   BI573517   BI591096   BI591131   BI607529   BI608966   BI610151   BI611641   BI613041   BI613867   BI614168   BI616436   BI617142   BI619901   BI621401   BI624204   BI624920   BI625936   BI631317   BI637740   BI637762   BP549732   BP549733   BP555667   BP555668   BT022770   BT022801   BT022982   BT023082   BT044475   CK134390   CO180425   CO187077   CO194979   CO269230   CO275573   CO276672   CO278634   CO280691   CO295322   CO295818   CO298712   CO298717   CO301906   CO302866   CO304194   CO306904   CO307078   CO321110   CO325595   CO326813   CO332761   CO338252   CO341146   CO342365   CO342912   CO343040   CO344640   CO345052   AE013599 EAA46156   EC051031   EC052541   EC053061   EC053547   EC055034   EC059655   EC061250   EC061919   EC063318   EC071662   EC078211   EC082841   EC083132   EC090679   EC209945   EC212985   EC213701   EC213926   EC214871   EC223455   EC225564   EC225565   EC226258   EC236028   EC239289   EC246181   EC254869   EC257310   EC258418   EC259449   EL873722   EL883976   EV595451   M80493   Z70846
UniProtKB/Swiss-Prot	P32865
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Cassill et al., 1991) adult stage   organism | ubiquitous   (Cassill et al., 1991) adult head   (Cassill et al., 1991) retina   (Cassill et al., 1991)
Additional Descriptive Data
	Gprk1 protein is found at all stages by western blot analysis. Immunohistochemical staining shows that it is ubiquitous in the adult fly. (Cassill et al., 1991)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0260798    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0260798 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 and 12-24 hour embryonic stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0260798 expression level Developmental Stage   Expression Level embryo 00-02hr    1019 embryo 02-04hr    1408 embryo 04-06hr    857 embryo 06-08hr    515 embryo 08-10hr    860 embryo 10-12hr    1050 embryo 12-14hr    1909 embryo 14-16hr    437 embryo 16-18hr    1073 embryo 18-20hr    550 embryo 20-22hr    731 embryo 22-24hr    1415 larva L1    316 larva L2    466 larva L3 12hr old    265 larva L3 puffstage 1-2    426 larva L3 puffstage 3-6    592 larva L3 puffstage 7-9    1209 white prepupae new    1319 white prepupae 12hr    1613 white prepupae 24hr    1623 pupae 2d postWPP    1594 pupae 3d postWPP    954 pupae 4d postWPP    243 adult male 01day    498 adult male 05day    365 adult male 30day    242 adult female 01day    222 adult female 05day    910 adult female 30day    666 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1019) embryo 02-04hr  (1408) embryo 04-06hr  (857) embryo 06-08hr  (515) embryo 08-10hr  (860) embryo 10-12hr  (1050) embryo 12-14hr  (1909) embryo 14-16hr  (437) embryo 16-18hr  (1073) embryo 18-20hr  (550) embryo 20-22hr  (731) embryo 22-24hr  (1415) larva L1  (316) larva L2  (466) larva L3 12hr old  (265) larva L3 puffstage 1-2  (426) larva L3 puffstage 3-6  (592) larva L3 puffstage 7-9  (1209) white prepupae new  (1319) white prepupae 12hr  (1613) white prepupae 24hr  (1623) pupae 2d postWPP  (1594) pupae 3d postWPP  (954) pupae 4d postWPP  (243) adult male 01day  (498) adult male 05day  (365) adult male 30day  (242) adult female 01day  (222) adult female 05day  (910) adult female 30day  (666) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1019 embryo 02-04hr  1408 embryo 04-06hr    857 embryo 06-08hr    515 embryo 08-10hr    860 embryo 10-12hr    1050 embryo 12-14hr  (1909) embryo 14-16hr    437 embryo 16-18hr    1073 embryo 18-20hr    550 embryo 20-22hr    731 embryo 22-24hr  1415 larva L1    316 larva L2    466 larva L3 12hr old    265 larva L3 puffstage 1-2    426 larva L3 puffstage 3-6    592 larva L3 puffstage 7-9    1209 white prepupae new    1319 white prepupae 12hr  (1613) white prepupae 24hr  (1623) pupae 2d postWPP  (1594) pupae 3d postWPP    954 pupae 4d postWPP    243 adult male 01day    498 adult male 05day    365 adult male 30day    242 adult female 01day    222 adult female 05day    910 adult female 30day    666 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1019 embryo 02-04hr    1408 embryo 04-06hr    857 embryo 06-08hr    515 embryo 08-10hr    860 embryo 10-12hr    1050 embryo 12-14hr    1909 embryo 14-16hr    437 embryo 16-18hr    1073 embryo 18-20hr    550 embryo 20-22hr    731 embryo 22-24hr    1415 larva L1    316 larva L2    466 larva L3 12hr old    265 larva L3 puffstage 1-2    426 larva L3 puffstage 3-6    592 larva L3 puffstage 7-9    1209 white prepupae new    1319 white prepupae 12hr    1613 white prepupae 24hr    1623 pupae 2d postWPP    1594 pupae 3d postWPP    954 pupae 4d postWPP    243 adult male 01day    498 adult male 05day    365 adult male 30day    242 adult female 01day    222 adult female 05day    910 adult female 30day    666 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1019 embryo 02-04hr    1408 embryo 04-06hr    857 embryo 06-08hr    515 embryo 08-10hr    860 embryo 10-12hr    1050 embryo 12-14hr    1909 embryo 14-16hr    437 embryo 16-18hr    1073 embryo 18-20hr    550 embryo 20-22hr    731 embryo 22-24hr    1415 larva L1    316 larva L2    466 larva L3 12hr old    265 larva L3 puffstage 1-2    426 larva L3 puffstage 3-6    592 larva L3 puffstage 7-9    1209 white prepupae new    1319 white prepupae 12hr    1613 white prepupae 24hr    1623 pupae 2d postWPP    1594 pupae 3d postWPP    954 pupae 4d postWPP    243 adult male 01day    498 adult male 05day    365 adult male 30day    242 adult female 01day    222 adult female 05day    910 adult female 30day    666 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0260798 expression level Developmental Stage   Expression Level embryo 00-02hr    1019 embryo 02-04hr    1408 embryo 04-06hr    857 embryo 06-08hr    515 embryo 08-10hr    860 embryo 10-12hr    1050 embryo 12-14hr    1909 embryo 14-16hr    437 embryo 16-18hr    1073 embryo 18-20hr    550 embryo 20-22hr    731 embryo 22-24hr    1415 larva L1    316 larva L2    466 larva L3 12hr old    265 larva L3 puffstage 1-2    426 larva L3 puffstage 3-6    592 larva L3 puffstage 7-9    1209 white prepupae new    1319 white prepupae 12hr    1613 white prepupae 24hr    1623 pupae 2d postWPP    1594 pupae 3d postWPP    954 pupae 4d postWPP    243 adult male 01day    498 adult male 05day    365 adult male 30day    242 adult female 01day    222 adult female 05day    910 adult female 30day    666 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1019) embryo 02-04hr  (1408) embryo 04-06hr  (857) embryo 06-08hr  (515) embryo 08-10hr  (860) embryo 10-12hr  (1050) embryo 12-14hr  (1909) embryo 14-16hr  (437) embryo 16-18hr  (1073) embryo 18-20hr  (550) embryo 20-22hr  (731) embryo 22-24hr  (1415) larva L1  (316) larva L2  (466) larva L3 12hr old  (265) larva L3 puffstage 1-2  (426) larva L3 puffstage 3-6  (592) larva L3 puffstage 7-9  (1209) white prepupae new  (1319) white prepupae 12hr  (1613) white prepupae 24hr  (1623) pupae 2d postWPP  (1594) pupae 3d postWPP  (954) pupae 4d postWPP  (243) adult male 01day  (498) adult male 05day  (365) adult male 30day  (242) adult female 01day  (222) adult female 05day  (910) adult female 30day  (666) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1019 embryo 02-04hr  1408 embryo 04-06hr    857 embryo 06-08hr    515 embryo 08-10hr    860 embryo 10-12hr    1050 embryo 12-14hr  1909 embryo 14-16hr    437 embryo 16-18hr    1073 embryo 18-20hr    550 embryo 20-22hr    731 embryo 22-24hr  1415 larva L1    316 larva L2    466 larva L3 12hr old    265 larva L3 puffstage 1-2    426 larva L3 puffstage 3-6    592 larva L3 puffstage 7-9    1209 white prepupae new    1319 white prepupae 12hr  1613 white prepupae 24hr  1623 pupae 2d postWPP  1594 pupae 3d postWPP    954 pupae 4d postWPP    243 adult male 01day    498 adult male 05day    365 adult male 30day    242 adult female 01day    222 adult female 05day    910 adult female 30day    666 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1019 embryo 02-04hr    1408 embryo 04-06hr    857 embryo 06-08hr    515 embryo 08-10hr    860 embryo 10-12hr    1050 embryo 12-14hr    1909 embryo 14-16hr    437 embryo 16-18hr    1073 embryo 18-20hr    550 embryo 20-22hr    731 embryo 22-24hr    1415 larva L1    316 larva L2    466 larva L3 12hr old    265 larva L3 puffstage 1-2    426 larva L3 puffstage 3-6    592 larva L3 puffstage 7-9    1209 white prepupae new    1319 white prepupae 12hr    1613 white prepupae 24hr    1623 pupae 2d postWPP    1594 pupae 3d postWPP    954 pupae 4d postWPP    243 adult male 01day    498 adult male 05day    365 adult male 30day    242 adult female 01day    222 adult female 05day    910 adult female 30day    666 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1019 embryo 02-04hr    1408 embryo 04-06hr    857 embryo 06-08hr    515 embryo 08-10hr    860 embryo 10-12hr    1050 embryo 12-14hr    1909 embryo 14-16hr    437 embryo 16-18hr    1073 embryo 18-20hr    550 embryo 20-22hr    731 embryo 22-24hr    1415 larva L1    316 larva L2    466 larva L3 12hr old    265 larva L3 puffstage 1-2    426 larva L3 puffstage 3-6    592 larva L3 puffstage 7-9    1209 white prepupae new    1319 white prepupae 12hr    1613 white prepupae 24hr    1623 pupae 2d postWPP    1594 pupae 3d postWPP    954 pupae 4d postWPP    243 adult male 01day    498 adult male 05day    365 adult male 30day    242 adult female 01day    222 adult female 05day    910 adult female 30day    666 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0260798    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0260798 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0260798 expression level Tissue   Expression Level Larval Central Nervous System    735.7 Larval Midgut    143.3 Larval Hindgut    261.5 Larval Malpighian Tubules    202.4 Larval Fat Body    144.9 Larval Salivary Gland    177.2 Larval Trachea    267.55 Larval Carcass    195.975 Adult Head    355.1 Adult Eye    337.025 Adult Brain    636.1 Adult Thoracic-Abdominal Ganglion    586.5 Adult Crop    337.7 Adult Midgut    106 Adult Hindgut    215.1 Adult Malpighian Tubules    121.8 Adult Fat Body    140.3 Adult Salivary Gland    218.4 Adult Heart    157.225 Adult VirginFemale Spermatheca    142.8 Adult InseminatedFemale Spermatheca    172.2 Adult Ovary    398.5 Adult Testis    53.1 Adult Male Accessory Gland    188.9 Adult Carcass    137.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (735.7) Larval Midgut    143.3 Larval Hindgut    261.5 Larval Malpighian Tubules    202.4 Larval Fat Body    144.9 Larval Salivary Gland    177.2 Larval Trachea    267.55 Larval Carcass    195.975 Adult Head    355.1 Adult Eye    337.025 Adult Brain  (636.1) Adult Thoracic-Abdominal Ganglion  (586.5) Adult Crop    337.7 Adult Midgut    106 Adult Hindgut    215.1 Adult Malpighian Tubules    121.8 Adult Fat Body    140.3 Adult Salivary Gland    218.4 Adult Heart    157.225 Adult VirginFemale Spermatheca    142.8 Adult InseminatedFemale Spermatheca    172.2 Adult Ovary    398.5 Adult Testis    53.1 Adult Male Accessory Gland    188.9 Adult Carcass    137.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    735.7 Larval Midgut    143.3 Larval Hindgut    261.5 Larval Malpighian Tubules    202.4 Larval Fat Body    144.9 Larval Salivary Gland    177.2 Larval Trachea    267.55 Larval Carcass    195.975 Adult Head    355.1 Adult Eye    337.025 Adult Brain    636.1 Adult Thoracic-Abdominal Ganglion    586.5 Adult Crop    337.7 Adult Midgut    106 Adult Hindgut    215.1 Adult Malpighian Tubules    121.8 Adult Fat Body    140.3 Adult Salivary Gland    218.4 Adult Heart    157.225 Adult VirginFemale Spermatheca    142.8 Adult InseminatedFemale Spermatheca    172.2 Adult Ovary    398.5 Adult Testis    53.1 Adult Male Accessory Gland    188.9 Adult Carcass    137.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    735.7 Larval Midgut    143.3 Larval Hindgut    261.5 Larval Malpighian Tubules    202.4 Larval Fat Body    144.9 Larval Salivary Gland    177.2 Larval Trachea    267.55 Larval Carcass    195.975 Adult Head    355.1 Adult Eye    337.025 Adult Brain    636.1 Adult Thoracic-Abdominal Ganglion    586.5 Adult Crop    337.7 Adult Midgut    106 Adult Hindgut    215.1 Adult Malpighian Tubules    121.8 Adult Fat Body    140.3 Adult Salivary Gland    218.4 Adult Heart    157.225 Adult VirginFemale Spermatheca    142.8 Adult InseminatedFemale Spermatheca    172.2 Adult Ovary    398.5 Adult Testis    53.1 Adult Male Accessory Gland    188.9 Adult Carcass    137.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0260798 expression level Tissue   Expression Level Larval Central Nervous System    735.7 Larval Midgut    143.3 Larval Hindgut    261.5 Larval Malpighian Tubules    202.4 Larval Fat Body    144.9 Larval Salivary Gland    177.2 Larval Trachea    267.55 Larval Carcass    195.975 Adult Head    355.1 Adult Eye    337.025 Adult Brain    636.1 Adult Thoracic-Abdominal Ganglion    586.5 Adult Crop    337.7 Adult Midgut    106 Adult Hindgut    215.1 Adult Malpighian Tubules    121.8 Adult Fat Body    140.3 Adult Salivary Gland    218.4 Adult Heart    157.225 Adult VirginFemale Spermatheca    142.8 Adult InseminatedFemale Spermatheca    172.2 Adult Ovary    398.5 Adult Testis    53.1 Adult Male Accessory Gland    188.9 Adult Carcass    137.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  735.7 Larval Midgut    143.3 Larval Hindgut    261.5 Larval Malpighian Tubules    202.4 Larval Fat Body    144.9 Larval Salivary Gland    177.2 Larval Trachea    267.55 Larval Carcass    195.975 Adult Head    355.1 Adult Eye    337.025 Adult Brain  636.1 Adult Thoracic-Abdominal Ganglion  586.5 Adult Crop    337.7 Adult Midgut    106 Adult Hindgut    215.1 Adult Malpighian Tubules    121.8 Adult Fat Body    140.3 Adult Salivary Gland    218.4 Adult Heart    157.225 Adult VirginFemale Spermatheca    142.8 Adult InseminatedFemale Spermatheca    172.2 Adult Ovary    398.5 Adult Testis    53.1 Adult Male Accessory Gland    188.9 Adult Carcass    137.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    735.7 Larval Midgut    143.3 Larval Hindgut    261.5 Larval Malpighian Tubules    202.4 Larval Fat Body    144.9 Larval Salivary Gland    177.2 Larval Trachea    267.55 Larval Carcass    195.975 Adult Head    355.1 Adult Eye    337.025 Adult Brain    636.1 Adult Thoracic-Abdominal Ganglion    586.5 Adult Crop    337.7 Adult Midgut    106 Adult Hindgut    215.1 Adult Malpighian Tubules    121.8 Adult Fat Body    140.3 Adult Salivary Gland    218.4 Adult Heart    157.225 Adult VirginFemale Spermatheca    142.8 Adult InseminatedFemale Spermatheca    172.2 Adult Ovary    398.5 Adult Testis    53.1 Adult Male Accessory Gland    188.9 Adult Carcass    137.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    735.7 Larval Midgut    143.3 Larval Hindgut    261.5 Larval Malpighian Tubules    202.4 Larval Fat Body    144.9 Larval Salivary Gland    177.2 Larval Trachea    267.55 Larval Carcass    195.975 Adult Head    355.1 Adult Eye    337.025 Adult Brain    636.1 Adult Thoracic-Abdominal Ganglion    586.5 Adult Crop    337.7 Adult Midgut    106 Adult Hindgut    215.1 Adult Malpighian Tubules    121.8 Adult Fat Body    140.3 Adult Salivary Gland    218.4 Adult Heart    157.225 Adult VirginFemale Spermatheca    142.8 Adult InseminatedFemale Spermatheca    172.2 Adult Ovary    398.5 Adult Testis    53.1 Adult Male Accessory Gland    188.9 Adult Carcass    137.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    355.1   NA  Eye    337.025   NA  Brain    636.1   735.7  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    586.5   NA  Crop    337.7   143.3  Midgut    106   261.5  Hindgut    215.1   202.4  Malpighian Tubules    121.8   144.9  Fat Body    140.3   177.2  Salivary Gland    218.4   NA  Heart    157.225   267.55  Trachea    NA   NA  VirginFemale Spermatheca    142.8   NA  InseminatedFemale Spermatheca    172.2   NA  Ovary    398.5   NA  Testis    53.1   NA  Male Accessory Gland    188.9   195.975  Carcass    137.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_05
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0260798
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Gprk1KO Other Phenotypes Allele neurophysiology defective | heat sensitive Gprk1hs.PL Gprk1K220R.hs.T:Hsap\MYC Phenotype manifest in Allele wing Gprk1KO
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Gprk1 Class Mutagen Stocks Known lesion Gprk1c03240 0 -- Gprk1KO recombination SCEI endonuclease FLPase 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Gprk1 Class Mutagen Stocks Known lesion Gprk1GL00133 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Gprk1hs.PL in vitro construct - regulatory fusion 1 Yes Gprk1JF02990 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Gprk1K220R.hs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 1 Yes Gprk1Scer\SceI.RS.cCa in vitro construct 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)247 (Coulthard et al., 2010) Df(2R)M41A2 (Coulthard et al., 2010)
Not disrupted in	Df(2R)34-2 (Coulthard et al., 2010)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{TRiP.GL00133} NA P{TRiP.JF02990} NA heat-shock construct P{hs-Gprk1.K220R} NA P{hs-Gprk1.L} NA characterization construct P{FRT(Gprk1.KO)} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{PB}Gprk1c03240 NA
Gene Ontology: Function, Process & Cellular Component ( 14 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from mutant phenotype (Lee et al., 2004) G-protein coupled receptor binding inferred from physical interaction with ninaE (Lee et al., 2004) phosphatidylinositol binding inferred from direct assay (Lee et al., 2004) rhodopsin kinase activity inferred from mutant phenotype (Lee et al., 2004)
Biological Process
CV term Evidence References
imaginal disc-derived wing vein specification inferred from genetic interaction with Gprk2 (Cheng et al., 2010) metarhodopsin inactivation inferred from mutant phenotype (Lee et al., 2004) phototransduction, visible light inferred from mutant phenotype (Lee et al., 2004) protein phosphorylation inferred from mutant phenotype (Lee et al., 2004)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
G-protein coupled receptor kinase activity inferred from electronic annotation with InterPro:IPR000239 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Cassill et al., 1991) non-traceable author statement (Swiss-Prot Project Members, 1993.10.1) protein serine/threonine kinase activity non-traceable author statement (Morrison et al., 2000)
Biological Process
CV term Evidence References
G-protein coupled receptor signaling pathway non-traceable author statement (Swiss-Prot Project Members, 1993.10.1) protein phosphorylation inferred from sequence or structural similarity (Cassill et al., 1991) non-traceable author statement (Morrison et al., 2000) regulation of G-protein coupled receptor protein signaling pathway inferred from sequence or structural similarity (FlyBase, 1992-) signal transduction inferred from sequence or structural similarity (Cassill et al., 1991) termination of G-protein coupled receptor signaling pathway inferred from electronic annotation with InterPro:IPR000342, InterPro:IPR016137 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Gprk1 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 78138 DroID - A comprehensive database of gene and protein interactions. • FBgn0260798 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 3355013
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL006868-PA Aedes aegypti (mosquito) AGAP012026-PA Anopheles gambiae (mosquito) XP_396647.3 Apis mellifera (honey bee) 218343 Branchiostoma floridae (lancelet) 59385 Branchiostoma floridae (lancelet) BGIBMGA005333-PA Bombyx mori (silk worm) ENSBTAP00000000005 Bos taurus (bovine) CN29675 Caenorhabditis brenneri (small nematode) CE32946 Caenorhabditis elegans (worm) ENSCAFP00000017324 Canis familiaris (dog) ENSCINP00000002847 Ciona intestinalis (sea squirt) JA02254 Caenorhabditis japonica (nematode) ENSCPOP00000013930 Cavia porcellus (guinea pig) RP04780 Caenorhabditis remanei (nematode) ENSCSAVP00000003176 Ciona savignyi (sedentary tunicate) 103369 Capitella spl (polychaete worm) 300795 Daphnia pulex (daphnia) ENSDARP00000094501 Danio rerio (zebra fish) ENSECAP00000003876 Equus caballus (horse) ENSGALP00000008839 Gallus gallus (chicken) 75424 Hypsipyla robusta (cedar shoot borer) ENSP00000312262 Homo sapiens (human) ISCW009785-PA Ixodes scapularis (deer tick) 144613 Lottia gigantea (owl limpet) 38629 Monocosta brevicollis (choanoflagellate) ENSMODP00000013172 Monodelphis domestica (gray opossum) ENSMMUP00000031333 Macaca mulatta (rhesus monkey) ENSMUSP00000086114 Mus musculus (house mouse) 246204 Nematostella vectensis (starlet anemone) XP_001604700.1 Nasonia vitripennis (wasp) ENSORLP00000001399 Oryzias latipes (japanese killifish) PFL2250c Plasmodium falciparum (protozoal parasite) PHUM004512-PA Pediculus humanus (human body louse) 116799 Physcomitrella patens (moss) ENSPPYP00000003477 Pongo pygmaeus (orangutan) 79028 Phytophthora ramorum (sudden oak death pathogen) 135923 Phytophthora sojae (root rot pathogen) ENSPTRP00000006793 Pan troglodytes (chimpanzee) ENSRNOP00000025847 Rattus norvegicus (norway rat) Smp_159010.1 Schistosoma mansoni (trematode parasite) 59012 Trichoplax adhaerens (metazoa) XP_966480.1 Tribolium castaneum (red flour beetle) ENSTNIP00000016581 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000047668 Takifugu rubripes (pufferfish Takifugu) 3732.m00034 Tetrahymena thermophila (ciliate protozoa) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13981 NV12967 LH24330 ISCW009785 FBgn0242147 FBgn0223369 FBgn0206836 FBgn0189244 FBgn0174230 JGI_V11_300795 FBgn0141593 FBgn0129173 FBgn0108942 FBgn0091841 CPIJ004656 CPIJ004653 BGIBMGA005333 GB15959 AGAP012026 AAEL006868 PHUM014910 GLEAN_05590
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	28802 cn1 bw1; P{hs-Gprk1.L}2 28800 cn1 bw1; P{hs-Gprk1.K220R}3 28354 y1 v1; P{TRiP.JF02990}attP2/TM3, Sb1 35246 y1 sc* v1; P{TRiP.GL00133}attP2/TM3, Sb1
Genomic Clones ( 1 )
	BACR04F06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 138 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP13720 IP13920
Other clones	AF171865 IP08451 IP08651 RE28112
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD08861 LD08975 RE61907 RH02041 RH04810 RH04851 RH05833 RH07230 RH07396 RH08030 RH08307 RH08317 RH08558 RH13688 RH15080 RH18014 RH34593 RH35086 RH42109 RH43122 RH43478 RH46385 RH47379 RH51038 RH52737 RH60871 RH62408 RH63639 RH63725 RH64663 RH66446 RH74613 SD03350 SD19808 SD19832
Other clones	578 1596 16552 19732 41671 59024 61711 65921 78166 79490 103113 105994 106034 145402 148127 165808 184039 214215.31 214317.37 214381.40 214499.40 277512 CK01.123B.H9 CK01.141C.C4 CK00355 CK00531 CK01449 CK01893 CK02355 Dmel_neb_012623_0638_0459 EC01538 EC39544 EC051031 EC052541 EC053061 EC053547 EC055034 EK026156 EK093929 EK117942 EK121811 EK130640 EK154631 EK173549 EK173559 EK182561 EK185048 EK196905 EK209429 EK211645 EK244063 EK252741 EK253456 EK290329 EK304463 EN16322 EP04702 EP11939 EP14563 EP15730 EP15964 EP19643 EP21212 FGM103B08 FGM236E05 IP13620 IP13820 LD08681 LD18925 LP06033 RE04456 RE08580 RE09390 RE11749 RE15464 RE16420 RE17354 RE17370 RE19831 RE20129 RE23129 RE36595 RE39023 RE40407 RE40661 RE42749 RE43235 RE43948 RE46236 RE55521 RE56190 RE57752 RE60311 RE63457 RE65957 RE67652 RH09130
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0260798 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 3355013
Antibody Information
	polyclonal (Cassill et al., 1991)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Gprk1 CG40129 (Drosophila Heterochromatin Genome Project, 2004) Source for merge of: Gprk1 Rok (FlyBase, 1992-)
Additional comments
Other Comments
	New annotation (CG40129) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Gprk1 has been cloned and sequenced. (Cassill et al., 1991)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001042973 NM_001169580 RefSeq (Proteins) • NP_001036438 NP_001163051 DDBJ / EMBL / GenBank • AAA28588 AABU01002711 ACZ94331 EAA46156 M80493 Z70846 Entrez Gene - A searchable database of RefSeq genes. • 3355013 UniProtKB/Swiss-Prot • P32865
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • GPCR kinase (IPR000239) Regulator of G protein signalling (IPR000342) Protein kinase, catalytic domain (IPR000719) AGC-kinase, C-terminal (IPR000961) Pleckstrin homology domain (IPR001849) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Pleckstrin homology-type (IPR011993) Regulator of G protein signalling superfamily (IPR016137) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442)
Linkouts
	BioGRID - A database of protein and genetic interactions • 78138 DroID - A comprehensive database of gene and protein interactions. • FBgn0260798 DRSC - Results from RNAi screens. • FBgn0260798 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0260798 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0260798 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 3355013 InParanoid A subset of ortholog calls from InParanoid. • AAEL006868-PA Aedes aegypti (mosquito) AGAP012026-PA Anopheles gambiae (mosquito) XP_396647.3 Apis mellifera (honey bee) 218343 Branchiostoma floridae (lancelet) 59385 Branchiostoma floridae (lancelet) BGIBMGA005333-PA Bombyx mori (silk worm) ENSBTAP00000000005 Bos taurus (bovine) CN29675 Caenorhabditis brenneri (small nematode) CE32946 Caenorhabditis elegans (worm) ENSCAFP00000017324 Canis familiaris (dog) ENSCINP00000002847 Ciona intestinalis (sea squirt) JA02254 Caenorhabditis japonica (nematode) ENSCPOP00000013930 Cavia porcellus (guinea pig) RP04780 Caenorhabditis remanei (nematode) ENSCSAVP00000003176 Ciona savignyi (sedentary tunicate) 103369 Capitella spl (polychaete worm) 300795 Daphnia pulex (daphnia) ENSDARP00000094501 Danio rerio (zebra fish) ENSECAP00000003876 Equus caballus (horse) ENSGALP00000008839 Gallus gallus (chicken) 75424 Hypsipyla robusta (cedar shoot borer) ENSP00000312262 Homo sapiens (human) ISCW009785-PA Ixodes scapularis (deer tick) 144613 Lottia gigantea (owl limpet) 38629 Monocosta brevicollis (choanoflagellate) ENSMODP00000013172 Monodelphis domestica (gray opossum) ENSMMUP00000031333 Macaca mulatta (rhesus monkey) ENSMUSP00000086114 Mus musculus (house mouse) 246204 Nematostella vectensis (starlet anemone) XP_001604700.1 Nasonia vitripennis (wasp) ENSORLP00000001399 Oryzias latipes (japanese killifish) PFL2250c Plasmodium falciparum (protozoal parasite) PHUM004512-PA Pediculus humanus (human body louse) 116799 Physcomitrella patens (moss) ENSPPYP00000003477 Pongo pygmaeus (orangutan) 79028 Phytophthora ramorum (sudden oak death pathogen) 135923 Phytophthora sojae (root rot pathogen) ENSPTRP00000006793 Pan troglodytes (chimpanzee) ENSRNOP00000025847 Rattus norvegicus (norway rat) Smp_159010.1 Schistosoma mansoni (trematode parasite) 59012 Trichoplax adhaerens (metazoa) XP_966480.1 Tribolium castaneum (red flour beetle) ENSTNIP00000016581 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000047668 Takifugu rubripes (pufferfish Takifugu) 3732.m00034 Tetrahymena thermophila (ciliate protozoa) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 3355013 modMine - Data generated by the modENCODE project. • FBgn0260798 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13981 NV12967 LH24330 ISCW009785 FBgn0242147 FBgn0223369 FBgn0206836 FBgn0189244 FBgn0174230 JGI_V11_300795 FBgn0141593 FBgn0129173 FBgn0108942 FBgn0091841 CPIJ004656 CPIJ004653 BGIBMGA005333 GB15959 AGAP012026 AAEL006868 PHUM014910 GLEAN_05590
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG40129 (Giot et al., 2003, Rossi et al., 2007, Perkins et al., 2009, Coulthard et al., 2010, Ni et al., 2011.7.19) CT4320 (Morrison et al., 2000) gprk1 (Lee et al., 2004) Gprk-1 (Brumby et al., 2004, Cassill et al., 1991) GPRK1 (Morrison et al., 2000) Gprk1 (Cheng et al., 2010, Coulthard et al., 2010) RK (Lee et al., 2004, Hardie, 2003) Rok
Name Synonym	G protein-coupled receptor kinase 1   rhodopsin kinase (Lee et al., 2004, Delmas et al., 2004, Hardie, 2003)
Secondary FlyBase IDs
	FBan0040129 FBgn0004833 FBgn0023488 FBgn0058129
References ( 24 )
Generate a list of	All references relating to this gene ( 24 )
List References by type	Research paper  ( 7 ) Supplementary material  ( 3 ) Review  ( 3 ) Personal communication to FlyBase  ( 6 ) FlyBase analysis  ( 3 ) Protein sequence record  ( 1 ) Computer file  ( 1 )
Recent research papers ( 3 )
	Chen et al., 2010, Genes Dev. 24(18): 2054--2067 G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila. [FBrf0211810] Cheng et al., 2010, Dev. Biol. 337(1): 99--109 Regulation of smoothened by Drosophila G-protein-coupled receptor kinases. [FBrf0209432] Coulthard et al., 2010, Genetics 185(2): 479--495 Essential loci in centromeric heterochromatin of Drosophila melanogaster. I: the right arm of chromosome 2. [FBrf0211235] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...