p120, p120ctn, p120-catenin, p120catenin, p120 catenin
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
There is only one protein coding transcript and one polypeptide associated with this gene
781 (aa); 88 (kD observed); 87 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\p120ctn using the Feature Mapper tool.
p120ctn transcripts are expressed in all cells during embryogenesis. Elevated levels are observed in several tissues, many of which are undergoing morphogenetic movements including the invaginating posterior midgut, CNS, migrating anterior and posterior midguts, foregut, hindgut, and cells in the midgut constriction.
In ovaries, p120ctn protein accumulates in the adherens junctions of epithelial follicle cells, at junctions between migrating border cells, and weakly in junctions between germ cells. In embryos, p120ctn protein accumulates at cell-cell adherens junctions in the epidermis and gut. The protein is present throughout embryogenesis, though the levels are lower in early embryonic stages than those of other core adherens junctions proteins such as arm protein and shg protein. p120ctn protein also accumulates in a variety of other tissues as observed in some cases by GFP staining. These include trachea, axons of the CNS, and sensory structures of the PNS. In eye imaginal discs, p120ctn protein localizes at cell-cell boundaries anterior to the morphogenetic furrow and at elevated levels where differentiating cells abut one another. In larval brains, @p120ctn localizes to cell-cell boundaries between nuroblasts, to GMCs, and to axons emerging from neuroblast progeny.
GBrowse - Visual display of RNA-Seq signalsView Dmel\p120ctn in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
p120ctn loss results in increase heat shock sensitivity and reduced animal lifespan.
Not an essential gene.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
p120ctn seems to encode an important positive modulator of cell adhesion though not itself an essential core component of the adherens junction.
A single member of the p120/δ-catenin family (p120ctn) is encoded in the D.melanogaster genome.
Identified by PCR based on homology to the vertebrate homologs.