FlyBase Gene Report: Dmel\dnr1

General Information

Symbol

Dmel\dnr1

Species

D. melanogaster

Name

defense repressor 1

Annotation Symbol

CG12489

Feature Type

protein_coding_gene

FlyBase ID

FBgn0260866

Gene Model Status

Current

Stock Availability

13 publicly available

Gene Snapshot

defense repressor 1 (dnr1) encodes a protein that interacts with the caspase encoded by Dredd. The product of dnr1 is involved in attenuation of innate immune response and neuro-inflammation. [Date last reviewed: 2019-02-28]

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

58E9-58F1

Sequence location

2R:22,563,152..22,592,964 [-]

Recombination map

2-100

RefSeq locus

NT_033778 REGION:22563152..22592964

Sequence

Get Decorated FASTA

Genomic Maps

GBrowse JBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

[Detailed GO annotations]

Gene Group (FlyBase)

OTHER RING DOMAIN UBIQUITIN LIGASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Molecular Function (GO)
[Detailed GO annotations]

Experimental Evidence

Predictions / Assertions

ubiquitin protein ligase activity; ubiquitin-protein transferase activity; zinc ion binding

Summaries

Gene Group (FlyBase)

OTHER RING DOMAIN UBIQUITIN LIGASES -: The RING (Really Interesting New Gene) finger domain co-ordinates two Zn²⁺ ions via conserved Cys and His residues. Most proteins which contain a RING finger are assumed to be ubiquitin (E3) ligases. The RING finger binds ubiquitin-conjugating enzymes (E2) and promotes direct transfer of ubiquitin to the target protein. (Adapted from FBrf0215242 and PMID:19489725).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\dnr1 or the JBrowse view of Dmel\dnr1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

gene_with_stop_codon_read_through ; SO:0000697

Stop-codon suppression (UAG) postulated; FBrf0216884

Gene model reviewed during 5.44

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene

gene

(Anonymous, 2005)

gene_with_edited_transcript

(Graveley et al., 2011)

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

dnr1-RA

FBtr0071837

NM_137836

3194

676

dnr1-RB

FBtr0330229

NM_001274208

3553

696

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

dnr1-PA

FBpp0071748

73.2

676

7.83

NP_611680

AAF46858

dnr1-PB

FBpp0303262

75.5

696

7.80

NP_001261137

AGB93668

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dnr1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

dnr1_1

Linkouts

Gene Ontology (8 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

ubiquitin protein ligase activity

inferred from sequence or structural similarity with UniProtKB:Q8WY64

(FlyBase Curators, 2008--)

ubiquitin-protein transferase activity

inferred from sequence or structural similarity with HGNC:21155

(FlyBase Curators, 2008--)

inferred from biological aspect of ancestor with PANTHER:PTN001150528

(assigned by GO_Central )

(Gaudet et al., 2011)

zinc ion binding

inferred from sequence model

(Ying et al., 2011)

Biological Process (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria

inferred from mutant phenotype

(Guntermann et al., 2009)

sleep

inferred from mutant phenotype

(Harbison and Sehgal, 2008)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

protein ubiquitination

inferred from sequence or structural similarity with HGNC:21155

(FlyBase Curators, 2008--)

ubiquitin-dependent protein catabolic process

inferred from biological aspect of ancestor with PANTHER:PTN001150528

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

cytoskeleton

inferred from electronic annotation with InterPro:IPR000299

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- 6

anlage in statu nascendi

(Fisher et al., 2012)

ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 7 -- 8

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

antennal primordium