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Gene Dmel\Ir76a

General Information
Symbol	Dmel\Ir76a	Species	D. melanogaster
Name	Ionotropic receptor 76a	Annotation symbol	CG42584
Feature type	protein_coding_gene	FlyBase ID	FBgn0260874
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	CG8533
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	76C6-76C6	Sequence location	3L:19,792,378..19,796,527 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ionotropic receptor 76a is referred to in FlyBase by the symbol Dmel\Ir76a (CG42584, FBgn0260874). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: extracellular-glutamate-gated ion channel activity; ligand-gated ion channel activity. There is experimental evidence that it is involved in the biological process: detection of chemical stimulus involved in sensory perception. 9 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Ionotropic glutamate receptor. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult brain. Comments on Affy2 ProbeSet: ProbeSet 1633880_s_at completely aligns to an exonic region common to each of the 5 FlyBase-annotated transcript isoforms of Ir76a. Gene sequence location is 3L:19792378..19796527.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 76C6-76C6
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ir76a for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46 Gene merge based on EST/cDNA data (GB:FJ495546)
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ir76a-RA FBtr0301604  NM_140891   1722   515 Ir76a-RB FBtr0301603  NM_168817   1761   515 Ir76a-RD FBtr0301606  NM_001144510   1735   121 Ir76a-RE FBtr0301607  NM_001104177   1991   646
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ir76a-PA   FBpp0290819   59.3   515   5.32     NP_649148   AAF49113 Ir76a-PB   FBpp0290818   59.3   515   5.32     NP_730452   AAN11633 Ir76a-PD   FBpp0290821   14.2   121   8.93     NP_001137982   ACL83337 Ir76a-PE   FBpp0290822   75.3   646   5.37     NP_001097647   ABW08571
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ionotropic glutamate receptor (IPR001320)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202378   AE014296 AAF49113   AE014296 AAN11633   AE014296 ABW08571   AE014296 ACL83337   AW941510   AY061057 AAL28605   BH610011   BI365552   BT099603   BT120322   CO262546   CO268176   CO297753   CO341868   CZ478860   CZ483974   EC059406   EC070904   EC085577   EC216990   EC219294   EC251816   GH797046   GH851933   GH962309   GH975062
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VW39 A8JNV9 B7Z084 Q7KUT6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference adult stage   neuron of antennal coeloconic sensillum ac4   (Benton et al., 2009)
Additional Descriptive Data
	Ir76a transcript is observed in the neurons of the antennal coeloconic sensillum ac4. In sensillum ac4 it is co-expressed with Ir76b, Ir75d and Ir84a. (Benton et al., 2009)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult brain. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    27.675 Larval Midgut    15.7 Larval Hindgut    10.2 Larval Malpighian Tubules    6.1 Larval Fat Body    12.5 Larval Salivary Gland    28.2 Larval Trachea    20.05 Larval Carcass    15.6 Adult Head    35 Adult Eye    33.275 Adult Brain    112.3 Adult Thoracic-Abdominal Ganglion    81.7 Adult Crop    38.8 Adult Midgut    13.7 Adult Hindgut    16.6 Adult Malpighian Tubules    7.9 Adult Fat Body    22.9 Adult Salivary Gland    35.7 Adult Heart    20.425 Adult VirginFemale Spermatheca    22 Adult InseminatedFemale Spermatheca    25.8 Adult Ovary    26.3 Adult Testis    21.2 Adult Male Accessory Gland    67.4 Adult Carcass    19.9 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    27.675 Larval Midgut    15.7 Larval Hindgut    10.2 Larval Malpighian Tubules    6.1 Larval Fat Body    12.5 Larval Salivary Gland    28.2 Larval Trachea    20.05 Larval Carcass    15.6 Adult Head    35 Adult Eye    33.275 Adult Brain    112.3 Adult Thoracic-Abdominal Ganglion    81.7 Adult Crop    38.8 Adult Midgut    13.7 Adult Hindgut    16.6 Adult Malpighian Tubules    7.9 Adult Fat Body    22.9 Adult Salivary Gland    35.7 Adult Heart    20.425 Adult VirginFemale Spermatheca    22 Adult InseminatedFemale Spermatheca    25.8 Adult Ovary    26.3 Adult Testis    21.2 Adult Male Accessory Gland    67.4 Adult Carcass    19.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    27.675 Larval Midgut    15.7 Larval Hindgut    10.2 Larval Malpighian Tubules    6.1 Larval Fat Body    12.5 Larval Salivary Gland    28.2 Larval Trachea    20.05 Larval Carcass    15.6 Adult Head    35 Adult Eye    33.275 Adult Brain    112.3 Adult Thoracic-Abdominal Ganglion    81.7 Adult Crop    38.8 Adult Midgut    13.7 Adult Hindgut    16.6 Adult Malpighian Tubules    7.9 Adult Fat Body    22.9 Adult Salivary Gland    35.7 Adult Heart    20.425 Adult VirginFemale Spermatheca    22 Adult InseminatedFemale Spermatheca    25.8 Adult Ovary    26.3 Adult Testis    21.2 Adult Male Accessory Gland    67.4 Adult Carcass    19.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    27.675 Larval Midgut    15.7 Larval Hindgut    10.2 Larval Malpighian Tubules    6.1 Larval Fat Body    12.5 Larval Salivary Gland    28.2 Larval Trachea    20.05 Larval Carcass    15.6 Adult Head    35 Adult Eye    33.275 Adult Brain    112.3 Adult Thoracic-Abdominal Ganglion    81.7 Adult Crop    38.8 Adult Midgut    13.7 Adult Hindgut    16.6 Adult Malpighian Tubules    7.9 Adult Fat Body    22.9 Adult Salivary Gland    35.7 Adult Heart    20.425 Adult VirginFemale Spermatheca    22 Adult InseminatedFemale Spermatheca    25.8 Adult Ovary    26.3 Adult Testis    21.2 Adult Male Accessory Gland    67.4 Adult Carcass    19.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    27.675 Larval Midgut    15.7 Larval Hindgut    10.2 Larval Malpighian Tubules    6.1 Larval Fat Body    12.5 Larval Salivary Gland    28.2 Larval Trachea    20.05 Larval Carcass    15.6 Adult Head    35 Adult Eye    33.275 Adult Brain    112.3 Adult Thoracic-Abdominal Ganglion    81.7 Adult Crop    38.8 Adult Midgut    13.7 Adult Hindgut    16.6 Adult Malpighian Tubules    7.9 Adult Fat Body    22.9 Adult Salivary Gland    35.7 Adult Heart    20.425 Adult VirginFemale Spermatheca    22 Adult InseminatedFemale Spermatheca    25.8 Adult Ovary    26.3 Adult Testis    21.2 Adult Male Accessory Gland    67.4 Adult Carcass    19.9 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    27.675 Larval Midgut    15.7 Larval Hindgut    10.2 Larval Malpighian Tubules    6.1 Larval Fat Body    12.5 Larval Salivary Gland    28.2 Larval Trachea    20.05 Larval Carcass    15.6 Adult Head    35 Adult Eye    33.275 Adult Brain    112.3 Adult Thoracic-Abdominal Ganglion    81.7 Adult Crop    38.8 Adult Midgut    13.7 Adult Hindgut    16.6 Adult Malpighian Tubules    7.9 Adult Fat Body    22.9 Adult Salivary Gland    35.7 Adult Heart    20.425 Adult VirginFemale Spermatheca    22 Adult InseminatedFemale Spermatheca    25.8 Adult Ovary    26.3 Adult Testis    21.2 Adult Male Accessory Gland    67.4 Adult Carcass    19.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    27.675 Larval Midgut    15.7 Larval Hindgut    10.2 Larval Malpighian Tubules    6.1 Larval Fat Body    12.5 Larval Salivary Gland    28.2 Larval Trachea    20.05 Larval Carcass    15.6 Adult Head    35 Adult Eye    33.275 Adult Brain    112.3 Adult Thoracic-Abdominal Ganglion    81.7 Adult Crop    38.8 Adult Midgut    13.7 Adult Hindgut    16.6 Adult Malpighian Tubules    7.9 Adult Fat Body    22.9 Adult Salivary Gland    35.7 Adult Heart    20.425 Adult VirginFemale Spermatheca    22 Adult InseminatedFemale Spermatheca    25.8 Adult Ovary    26.3 Adult Testis    21.2 Adult Male Accessory Gland    67.4 Adult Carcass    19.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    27.675 Larval Midgut    15.7 Larval Hindgut    10.2 Larval Malpighian Tubules    6.1 Larval Fat Body    12.5 Larval Salivary Gland    28.2 Larval Trachea    20.05 Larval Carcass    15.6 Adult Head    35 Adult Eye    33.275 Adult Brain    112.3 Adult Thoracic-Abdominal Ganglion    81.7 Adult Crop    38.8 Adult Midgut    13.7 Adult Hindgut    16.6 Adult Malpighian Tubules    7.9 Adult Fat Body    22.9 Adult Salivary Gland    35.7 Adult Heart    20.425 Adult VirginFemale Spermatheca    22 Adult InseminatedFemale Spermatheca    25.8 Adult Ovary    26.3 Adult Testis    21.2 Adult Male Accessory Gland    67.4 Adult Carcass    19.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    35   NA  Eye    33.275   NA  Brain    112.3   no informative data  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    81.7   NA  Crop    no informative data   no informative data  Midgut    no informative data   no informative data  Hindgut    no informative data   6.1  Malpighian Tubules    7.9   no informative data  Fat Body    no informative data   no informative data  Salivary Gland    no informative data   NA  Heart    20.425   20.05  Trachea    NA   NA  VirginFemale Spermatheca    22   NA  InseminatedFemale Spermatheca    25.8   NA  Ovary    26.3   NA  Testis    21.2   NA  Male Accessory Gland    67.4   no informative data  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    0 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    0 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    0 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    0 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    0 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    0 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    0 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    0 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    1 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    5 embryo 04-06hr    2 embryo 06-08hr    2 embryo 08-10hr    3 embryo 10-12hr    3 embryo 12-14hr    3 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    5 white prepupae new    4 white prepupae 12hr    6 white prepupae 24hr    7 pupae 2d postWPP    7 pupae 3d postWPP    4 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    4 adult male 30day    5 adult female 01day    4 adult female 05day    6 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    5 embryo 04-06hr    2 embryo 06-08hr    2 embryo 08-10hr    3 embryo 10-12hr    3 embryo 12-14hr    3 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    5 white prepupae new    4 white prepupae 12hr    6 white prepupae 24hr    7 pupae 2d postWPP    7 pupae 3d postWPP    4 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    4 adult male 30day    5 adult female 01day    4 adult female 05day    6 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    5 embryo 04-06hr    2 embryo 06-08hr    2 embryo 08-10hr    3 embryo 10-12hr    3 embryo 12-14hr    3 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    5 white prepupae new    4 white prepupae 12hr    6 white prepupae 24hr    7 pupae 2d postWPP    7 pupae 3d postWPP    4 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    4 adult male 30day    5 adult female 01day    4 adult female 05day    6 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    5 embryo 04-06hr    2 embryo 06-08hr    2 embryo 08-10hr    3 embryo 10-12hr    3 embryo 12-14hr    3 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    5 white prepupae new    4 white prepupae 12hr    6 white prepupae 24hr    7 pupae 2d postWPP    7 pupae 3d postWPP    4 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    4 adult male 30day    5 adult female 01day    4 adult female 05day    6 adult female 30day    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    5 embryo 04-06hr    2 embryo 06-08hr    2 embryo 08-10hr    3 embryo 10-12hr    3 embryo 12-14hr    3 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    5 white prepupae new    4 white prepupae 12hr    6 white prepupae 24hr    7 pupae 2d postWPP    7 pupae 3d postWPP    4 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    4 adult male 30day    5 adult female 01day    4 adult female 05day    6 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    5 embryo 04-06hr    2 embryo 06-08hr    2 embryo 08-10hr    3 embryo 10-12hr    3 embryo 12-14hr    3 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    5 white prepupae new    4 white prepupae 12hr    6 white prepupae 24hr    7 pupae 2d postWPP    7 pupae 3d postWPP    4 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    4 adult male 30day    5 adult female 01day    4 adult female 05day    6 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    5 embryo 04-06hr    2 embryo 06-08hr    2 embryo 08-10hr    3 embryo 10-12hr    3 embryo 12-14hr    3 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    5 white prepupae new    4 white prepupae 12hr    6 white prepupae 24hr    7 pupae 2d postWPP    7 pupae 3d postWPP    4 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    4 adult male 30day    5 adult female 01day    4 adult female 05day    6 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    7 embryo 02-04hr    5 embryo 04-06hr    2 embryo 06-08hr    2 embryo 08-10hr    3 embryo 10-12hr    3 embryo 12-14hr    3 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    5 white prepupae new    4 white prepupae 12hr    6 white prepupae 24hr    7 pupae 2d postWPP    7 pupae 3d postWPP    4 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    4 adult male 30day    5 adult female 01day    4 adult female 05day    6 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    2 embryonic 1182-4H    1 embryonic GM2    6 embryonic Kc167    4 embryonic S1    21 embryonic S3    16 leg disc CME L1    1 wing disc CME-W2    8 wing disc ML-DmD8    0 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    11 ovary fGS/OSS    2 ovary OSC    5 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    2 embryonic 1182-4H    1 embryonic GM2    6 embryonic Kc167    4 embryonic S1    21 embryonic S3    16 leg disc CME L1    1 wing disc CME-W2    8 wing disc ML-DmD8    0 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    11 ovary fGS/OSS    2 ovary OSC    5 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    2 embryonic 1182-4H    1 embryonic GM2    6 embryonic Kc167    4 embryonic S1    21 embryonic S3    16 leg disc CME L1    1 wing disc CME-W2    8 wing disc ML-DmD8    0 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    11 ovary fGS/OSS    2 ovary OSC    5 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    2 embryonic 1182-4H    1 embryonic GM2    6 embryonic Kc167    4 embryonic S1    21 embryonic S3    16 leg disc CME L1    1 wing disc CME-W2    8 wing disc ML-DmD8    0 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    11 ovary fGS/OSS    2 ovary OSC    5 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    2 embryonic 1182-4H    1 embryonic GM2    6 embryonic Kc167    4 embryonic S1    21 embryonic S3    16 leg disc CME L1    1 wing disc CME-W2    8 wing disc ML-DmD8    0 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    11 ovary fGS/OSS    2 ovary OSC    5 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    2 embryonic 1182-4H    1 embryonic GM2    6 embryonic Kc167    4 embryonic S1    21 embryonic S3    16 leg disc CME L1    1 wing disc CME-W2    8 wing disc ML-DmD8    0 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    11 ovary fGS/OSS    2 ovary OSC    5 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    2 embryonic 1182-4H    1 embryonic GM2    6 embryonic Kc167    4 embryonic S1    21 embryonic S3    16 leg disc CME L1    1 wing disc CME-W2    8 wing disc ML-DmD8    0 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    11 ovary fGS/OSS    2 ovary OSC    5 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    2 embryonic 1182-4H    1 embryonic GM2    6 embryonic Kc167    4 embryonic S1    21 embryonic S3    16 leg disc CME L1    1 wing disc CME-W2    8 wing disc ML-DmD8    0 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    11 ovary fGS/OSS    2 ovary OSC    5 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_06
External Data & Images
Linkouts	BDGP expression data • LD02552 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0260874
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Ir76aα1S1 viable, with Dcr-2Scer\UAS.cDa, Scer\GAL4e22c, Scer\GAL4sqh.PW Ir76aKK104048 Phenotype manifest in Allele
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of Ir76a Class Mutagen Stocks Known lesion Ir76aKG00196 P-element activity 2 -- Ir76ae01030 piggyBac transposase 1 -- Ir76af01501 piggyBac transposase 1 -- Ir76aα1S1 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ir76a Class Mutagen Stocks Known lesion Ir76aHMS01156 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ir76aKK104048 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ir76aScer\UAS.cBa in vitro construct - regulatory fusion 1 Yes Ir76aGD2735 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Ir76aNIG.8533R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Partially disrupted in	Df(3L)α1S1 (Ratan et al., 2008)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data GAL4 construct P{Ir76a-GAL4.PB} No UAS construct P{KK104048} NA P{NIG.8533R} NA P{TRiP.HMS01156} NA P{UAS-Ir76a.B} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}Ir76aKG00196 NA PBac{RB}Ir76ae01030 NA PBac{WH}Ir76af01501 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
detection of chemical stimulus involved in sensory perception inferred from expression pattern (Benton et al., 2009)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
extracellular-glutamate-gated ion channel activity inferred from electronic annotation with InterPro:IPR001320 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Littleton and Ganetzky, 2000) ionotropic glutamate receptor activity inferred from electronic annotation with InterPro:IPR001320 (FlyBase Curators et al., 2004-) ligand-gated ion channel activity inferred from sequence model (Benton et al., 2009)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
integral to membrane inferred from sequence model (Benton et al., 2009) membrane inferred from electronic annotation with InterPro:IPR001320 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene (FlyBase Genome Annotators, 2007)
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ir76a allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0260874
Orthologs
OrthoDB Orthologs (31) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG60CJ2X Dipteran inclusive ortholog search EOG6DZ23W Insect inclusive ortholog search EOG69P8V2 Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG60CJ2X)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Ir76a     Drosophila simulans   Dsim\GD14827 Y   Drosophila sechellia   Dsec\GM19647 Y   Drosophila erecta   Dere\GG16057 Y   Drosophila yakuba   Dyak\GE15192     Drosophila yakuba   Dyak\GE19623 Y   Drosophila ananassae   Dana\GF23592 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA23782 Y   Drosophila persimilis   Dper\GL15733 Y   Drosophila willistoni   Dwil\GK17497 Y   Drosophila virilis   Dvir\GJ11321 Y   Drosophila mojavensis   Dmoj\GI11641 Y   Drosophila grimshawi   Dgri\GH14655 Y
Orthologs in non-Drosophila Dipterans (EOG6DZ23W)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000047 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000018 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000089 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000039 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000031 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000066 Y Anopheles gambiae Malaria mosquito  Agam\AGAP008759 Y Anopheles gambiae Malaria mosquito  Agam\AGAP012969 Y Anopheles gambiae Malaria mosquito  Agam\AGAP012872 Y Anopheles gambiae Malaria mosquito  Agam\AGAP012951 Y Anopheles gambiae Malaria mosquito  Agam\AGAP004432 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016960 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016957 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016953 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016954 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016964 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016959 Y
Orthologs in non-Dipteran Insects (EOG69P8V2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG001380 Y
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD14827 Drosophila sechellia Dsec\GM19647 Drosophila erecta Dere\GG16057 Drosophila yakuba Dyak\GE19623 Drosophila ananassae Dana\GF23592 Drosophila pseudoobscura pseudoobscura Dpse\GA23782 Drosophila persimilis Dper\GL15733 Drosophila willistoni Dwil\GK17497 Drosophila virilis Dvir\GJ11321 Drosophila mojavensis Dmoj\GI11641 Drosophila grimshawi Dgri\GH14655
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	41738 w*; P{UAS-Ir76a.B}294.3; TM2/TM6B, Tb1 34678 y1 sc* v1; P{TRiP.HMS01156}attP2 13060 y1 w67c23; P{SUPor-P}Ir76aKG00196 ry506 25396 w*; Df(3L)α1S1, P{SUPor-P}Ir76aKG00196/TM6B, Tb1
Harvard	- PBac{RB}Ir76ae01030 - PBac{WH}Ir76af01501
VDRC	v101590 P{KK104048}VIE-260B
Genomic Clones ( 1 )
	BACR01B21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 17 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD02552 RE39867 SD10765
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE50908
Other clones	56926 214213.46 CK01.101C.B12 CK01.107C.D8 CK01.111C.H5 EK085730 EK090448 EK170460 EP13314 RP003015646 RP003591666 RP004351018 RP004526624
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0260874 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40157
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Ir76a CG8533 (Benton et al., 2009)
Source for database merge of	Source for merge of: Ir76a CG34257 (FlyBase Genome Annotators, 2009, Benton et al., 2009)
Additional comments	Annotations CG8533 and CG34257 merged as CG42584 in release 5.17 of the genome annotation. (FlyBase Genome Annotators, 2009)
Other Comments
	New annotation (CG34257) in release 5.2 of the genome annotation. (FlyBase Genome Annotators, 2007)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140891 NM_168817 NM_001104177 NM_001144510 RefSeq (Proteins) • NP_649148 NP_730452 NP_001097647 NP_001137982 DDBJ / EMBL / GenBank • AA202378 AAF49113 AAG22571 AAL28605 AAN11633 ABW08571 ACL83337 AW941510 AY061057 BH610011 CZ478860 CZ483974 Entrez Gene - A searchable database of RefSeq genes. • 40157 UniProtKB/TrEMBL • A8JNV9 B7Z084 Q7KUT6 Q9VW39
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ionotropic glutamate receptor (IPR001320) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD02552
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0260874 DRSC - Results from RNAi screens. • FBgn0260874 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0260874 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0260874 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40157 modMine - Data generated by the modENCODE project. • FBgn0260874
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	CG8533 (Ratan et al., 2008, Benton et al., 2009, Lee et al., 2009, Croset et al., 2010, Yang et al., 2004, Keleman et al., 2009.8.5, Japanese National Institute of Genetics, 2012.5.21) CG34257 (FlyBase Genome Annotators, 2007) CG42584 (FlyBase Genome Annotators, 2009, Ni et al., 2010.12.1, Tsubouchi et al., 2012) CT24909 (Littleton and Ganetzky, 2000) DmelIR76a (Croset et al., 2010) IR76a (Benton et al., 2009, Silbering et al., 2011, Marshall et al., 2010, Benton et al., 2009, Croset et al., 2010, Abuin et al., 2011, Endo et al., 2011) Ir76a (Cooper et al., 2010, Ou et al., 2011, Tsubouchi et al., 2012, Senthilan et al., 2012)
Name Synonym	CG8533   ionotropic receptor 76a (Benton et al., 2009) Ionotropic receptor 76a (Tsubouchi et al., 2012)
Secondary FlyBase IDs
	FBgn0036907 FBgn0085286
References ( 30 )
Generate a list of	All references relating to this gene ( 30 )
List References by type	Research paper  ( 14 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 6 ) FlyBase analysis  ( 3 ) Stock list  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 5 )
	Senthilan et al., 2012, Cell 150(5): 1042--1054 Drosophila auditory organ genes and genetic hearing defects. [FBrf0219321] Abuin et al., 2011, Neuron 69(1): 44--60 Functional architecture of olfactory ionotropic glutamate receptors. [FBrf0212725] Endo et al., 2011, Nat. Neurosci. 15(2): 224--233 Chromatin modification of Notch targets in olfactory receptor neuron diversification. [FBrf0217319] Ou et al., 2011, PLoS Biol. 9(9): e1001160 Nuclear Receptor DHR4 Controls the Timing of Steroid Hormone Pulses During Drosophila Development. [FBrf0216318] Silbering et al., 2011, J. Neurosci. 31(38): 13357--13375 Complementary Function and Integrated Wiring of the Evolutionarily Distinct Drosophila Olfactory Subsystems. [FBrf0215822] Show all research papers ...