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Gene Dmel\rempA

General Information
Symbol	Dmel\rempA	Species	D. melanogaster
Name	reduced mechanoreceptor potential A	Annotation symbol	CG11838
Feature type	protein_coding_gene	FlyBase ID	FBgn0260933
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	oseg3, remp, CHE-11, IFT140
Genomic Location
Chromosome (arm)	2L	Recombination map	2-
Cytogenetic map	21E2-21E2	Sequence location	2L:553,742..560,310 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene reduced mechanoreceptor potential A is referred to in FlyBase by the symbol Dmel\rempA (CG11838, FBgn0260933). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: binding. There is experimental evidence that it is involved in the biological process: cilium assembly; sensory perception of sound; nonmotile primary cilium assembly; intraflagellar transport. 9 alleles are reported. The phenotypes of these alleles are annotated with: adult antennal nerve; leg; wing. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Tetratricopeptide-like helical; WD40 repeat; WD40 repeat-like-containing domain; WD40-repeat-containing domain; WD40/YVTN repeat-like-containing domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of very low expression. Peak expression observed within 06-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1632552_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of rempA. Gene sequence location is 2L:553742..560310.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features HFA00327 BKN20960
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 21E2-21E2   Limits computationally determined from genome sequence between P{lacW}l(2)k09610k09610&P{lacW}Sk09538a and P{PZ}l(2)1068510685&P{lacW}Tango14k00619
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	2- (Kernan et al., 1994)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\rempA for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) rempA-RB FBtr0078078  NM_205886   5024   1503 rempA-RC FBtr0303763  NM_134686   5308   1458
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein rempA-PB   FBpp0077738   168.0   1503   5.74     NP_995608   AAS64635 rempA-PC   FBpp0292775   163.1   1458   5.94     NP_608530   AAF51483
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • WD40/YVTN repeat-like-containing domain (IPR015943) WD40-repeat-containing domain (IPR017986) WD40 repeat (IPR001680) WD40 repeat-like-containing domain (IPR011046) Tetratricopeptide-like helical (IPR011990)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF51483   AE014134 AAS64635   BT021360 AAX33508   BT025848
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q5BI64 Q7KTZ4 Q9VPR0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0260933    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0260933 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of very low expression. Peak expression observed within 06-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0260933 expression level Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    30 embryo 04-06hr    48 embryo 06-08hr    124 embryo 08-10hr    220 embryo 10-12hr    348 embryo 12-14hr    291 embryo 14-16hr    225 embryo 16-18hr    143 embryo 18-20hr    124 embryo 20-22hr    80 embryo 22-24hr    104 larva L1    104 larva L2    52 larva L3 12hr old    41 larva L3 puffstage 1-2    48 larva L3 puffstage 3-6    90 larva L3 puffstage 7-9    106 white prepupae new    109 white prepupae 12hr    166 white prepupae 24hr    305 pupae 2d postWPP    288 pupae 3d postWPP    112 pupae 4d postWPP    141 adult male 01day    165 adult male 05day    231 adult male 30day    247 adult female 01day    57 adult female 05day    28 adult female 30day    46 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    30 embryo 04-06hr    48 embryo 06-08hr  (124) embryo 08-10hr  (220) embryo 10-12hr  (348) embryo 12-14hr  (291) embryo 14-16hr  (225) embryo 16-18hr  (143) embryo 18-20hr  (124) embryo 20-22hr    80 embryo 22-24hr  104 larva L1  104 larva L2    52 larva L3 12hr old    41 larva L3 puffstage 1-2    48 larva L3 puffstage 3-6    90 larva L3 puffstage 7-9  106 white prepupae new  (109) white prepupae 12hr  (166) white prepupae 24hr  (305) pupae 2d postWPP  (288) pupae 3d postWPP  (112) pupae 4d postWPP  (141) adult male 01day  (165) adult male 05day  (231) adult male 30day  (247) adult female 01day    57 adult female 05day    28 adult female 30day    46 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    30 embryo 04-06hr    48 embryo 06-08hr    124 embryo 08-10hr    220 embryo 10-12hr    348 embryo 12-14hr    291 embryo 14-16hr    225 embryo 16-18hr    143 embryo 18-20hr    124 embryo 20-22hr    80 embryo 22-24hr    104 larva L1    104 larva L2    52 larva L3 12hr old    41 larva L3 puffstage 1-2    48 larva L3 puffstage 3-6    90 larva L3 puffstage 7-9    106 white prepupae new    109 white prepupae 12hr    166 white prepupae 24hr    305 pupae 2d postWPP    288 pupae 3d postWPP    112 pupae 4d postWPP    141 adult male 01day    165 adult male 05day    231 adult male 30day    247 adult female 01day    57 adult female 05day    28 adult female 30day    46 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    30 embryo 04-06hr    48 embryo 06-08hr    124 embryo 08-10hr    220 embryo 10-12hr    348 embryo 12-14hr    291 embryo 14-16hr    225 embryo 16-18hr    143 embryo 18-20hr    124 embryo 20-22hr    80 embryo 22-24hr    104 larva L1    104 larva L2    52 larva L3 12hr old    41 larva L3 puffstage 1-2    48 larva L3 puffstage 3-6    90 larva L3 puffstage 7-9    106 white prepupae new    109 white prepupae 12hr    166 white prepupae 24hr    305 pupae 2d postWPP    288 pupae 3d postWPP    112 pupae 4d postWPP    141 adult male 01day    165 adult male 05day    231 adult male 30day    247 adult female 01day    57 adult female 05day    28 adult female 30day    46 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    30 embryo 04-06hr    48 embryo 06-08hr    124 embryo 08-10hr    220 embryo 10-12hr    348 embryo 12-14hr    291 embryo 14-16hr    225 embryo 16-18hr    143 embryo 18-20hr    124 embryo 20-22hr    80 embryo 22-24hr    104 larva L1    104 larva L2    52 larva L3 12hr old    41 larva L3 puffstage 1-2    48 larva L3 puffstage 3-6    90 larva L3 puffstage 7-9    106 white prepupae new    109 white prepupae 12hr    166 white prepupae 24hr    305 pupae 2d postWPP    288 pupae 3d postWPP    112 pupae 4d postWPP    141 adult male 01day    165 adult male 05day    231 adult male 30day    247 adult female 01day    57 adult female 05day    28 adult female 30day    46 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0260933 expression level Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    30 embryo 04-06hr    48 embryo 06-08hr    124 embryo 08-10hr    220 embryo 10-12hr    348 embryo 12-14hr    291 embryo 14-16hr    225 embryo 16-18hr    143 embryo 18-20hr    124 embryo 20-22hr    80 embryo 22-24hr    104 larva L1    104 larva L2    52 larva L3 12hr old    41 larva L3 puffstage 1-2    48 larva L3 puffstage 3-6    90 larva L3 puffstage 7-9    106 white prepupae new    109 white prepupae 12hr    166 white prepupae 24hr    305 pupae 2d postWPP    288 pupae 3d postWPP    112 pupae 4d postWPP    141 adult male 01day    165 adult male 05day    231 adult male 30day    247 adult female 01day    57 adult female 05day    28 adult female 30day    46 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    30 embryo 04-06hr    48 embryo 06-08hr  124 embryo 08-10hr  (220) embryo 10-12hr  (348) embryo 12-14hr  (291) embryo 14-16hr  (225) embryo 16-18hr  143 embryo 18-20hr  124 embryo 20-22hr    80 embryo 22-24hr  104 larva L1  104 larva L2    52 larva L3 12hr old    41 larva L3 puffstage 1-2    48 larva L3 puffstage 3-6    90 larva L3 puffstage 7-9  106 white prepupae new  109 white prepupae 12hr  (166) white prepupae 24hr  (305) pupae 2d postWPP  (288) pupae 3d postWPP  112 pupae 4d postWPP  141 adult male 01day  (165) adult male 05day  (231) adult male 30day  (247) adult female 01day    57 adult female 05day    28 adult female 30day    46 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    30 embryo 04-06hr    48 embryo 06-08hr    124 embryo 08-10hr    220 embryo 10-12hr    348 embryo 12-14hr    291 embryo 14-16hr    225 embryo 16-18hr    143 embryo 18-20hr    124 embryo 20-22hr    80 embryo 22-24hr    104 larva L1    104 larva L2    52 larva L3 12hr old    41 larva L3 puffstage 1-2    48 larva L3 puffstage 3-6    90 larva L3 puffstage 7-9    106 white prepupae new    109 white prepupae 12hr    166 white prepupae 24hr    305 pupae 2d postWPP    288 pupae 3d postWPP    112 pupae 4d postWPP    141 adult male 01day    165 adult male 05day    231 adult male 30day    247 adult female 01day    57 adult female 05day    28 adult female 30day    46 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    30 embryo 04-06hr    48 embryo 06-08hr    124 embryo 08-10hr    220 embryo 10-12hr    348 embryo 12-14hr    291 embryo 14-16hr    225 embryo 16-18hr    143 embryo 18-20hr    124 embryo 20-22hr    80 embryo 22-24hr    104 larva L1    104 larva L2    52 larva L3 12hr old    41 larva L3 puffstage 1-2    48 larva L3 puffstage 3-6    90 larva L3 puffstage 7-9    106 white prepupae new    109 white prepupae 12hr    166 white prepupae 24hr    305 pupae 2d postWPP    288 pupae 3d postWPP    112 pupae 4d postWPP    141 adult male 01day    165 adult male 05day    231 adult male 30day    247 adult female 01day    57 adult female 05day    28 adult female 30day    46 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    30 embryo 04-06hr    48 embryo 06-08hr    124 embryo 08-10hr    220 embryo 10-12hr    348 embryo 12-14hr    291 embryo 14-16hr    225 embryo 16-18hr    143 embryo 18-20hr    124 embryo 20-22hr    80 embryo 22-24hr    104 larva L1    104 larva L2    52 larva L3 12hr old    41 larva L3 puffstage 1-2    48 larva L3 puffstage 3-6    90 larva L3 puffstage 7-9    106 white prepupae new    109 white prepupae 12hr    166 white prepupae 24hr    305 pupae 2d postWPP    288 pupae 3d postWPP    112 pupae 4d postWPP    141 adult male 01day    165 adult male 05day    231 adult male 30day    247 adult female 01day    57 adult female 05day    28 adult female 30day    46 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0260933    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0260933 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0260933 expression level Tissue   Expression Level Larval Central Nervous System    8.4 Larval Midgut    1 Larval Hindgut    1 Larval Malpighian Tubules    2.6 Larval Fat Body    1.4 Larval Salivary Gland    1.6 Larval Trachea    1.15 Larval Carcass    1.6 Adult Head    5.3 Adult Eye    3.5 Adult Brain    1.2 Adult Thoracic-Abdominal Ganglion    3.1 Adult Crop    3.5 Adult Midgut    7.1 Adult Hindgut    2.9 Adult Malpighian Tubules    1.3 Adult Fat Body    1.4 Adult Salivary Gland    3.8 Adult Heart    0.675 Adult VirginFemale Spermatheca    0.8 Adult InseminatedFemale Spermatheca    0.9 Adult Ovary    1.5 Adult Testis    8.4 Adult Male Accessory Gland    6.2 Adult Carcass    4.8 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    8.4 Larval Midgut    1 Larval Hindgut    1 Larval Malpighian Tubules    2.6 Larval Fat Body    1.4 Larval Salivary Gland    1.6 Larval Trachea    1.15 Larval Carcass    1.6 Adult Head    5.3 Adult Eye    3.5 Adult Brain    1.2 Adult Thoracic-Abdominal Ganglion    3.1 Adult Crop    3.5 Adult Midgut    7.1 Adult Hindgut    2.9 Adult Malpighian Tubules    1.3 Adult Fat Body    1.4 Adult Salivary Gland    3.8 Adult Heart    0.675 Adult VirginFemale Spermatheca    0.8 Adult InseminatedFemale Spermatheca    0.9 Adult Ovary    1.5 Adult Testis    8.4 Adult Male Accessory Gland    6.2 Adult Carcass    4.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    8.4 Larval Midgut    1 Larval Hindgut    1 Larval Malpighian Tubules    2.6 Larval Fat Body    1.4 Larval Salivary Gland    1.6 Larval Trachea    1.15 Larval Carcass    1.6 Adult Head    5.3 Adult Eye    3.5 Adult Brain    1.2 Adult Thoracic-Abdominal Ganglion    3.1 Adult Crop    3.5 Adult Midgut    7.1 Adult Hindgut    2.9 Adult Malpighian Tubules    1.3 Adult Fat Body    1.4 Adult Salivary Gland    3.8 Adult Heart    0.675 Adult VirginFemale Spermatheca    0.8 Adult InseminatedFemale Spermatheca    0.9 Adult Ovary    1.5 Adult Testis    8.4 Adult Male Accessory Gland    6.2 Adult Carcass    4.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    8.4 Larval Midgut    1 Larval Hindgut    1 Larval Malpighian Tubules    2.6 Larval Fat Body    1.4 Larval Salivary Gland    1.6 Larval Trachea    1.15 Larval Carcass    1.6 Adult Head    5.3 Adult Eye    3.5 Adult Brain    1.2 Adult Thoracic-Abdominal Ganglion    3.1 Adult Crop    3.5 Adult Midgut    7.1 Adult Hindgut    2.9 Adult Malpighian Tubules    1.3 Adult Fat Body    1.4 Adult Salivary Gland    3.8 Adult Heart    0.675 Adult VirginFemale Spermatheca    0.8 Adult InseminatedFemale Spermatheca    0.9 Adult Ovary    1.5 Adult Testis    8.4 Adult Male Accessory Gland    6.2 Adult Carcass    4.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0260933 expression level Tissue   Expression Level Larval Central Nervous System    8.4 Larval Midgut    1 Larval Hindgut    1 Larval Malpighian Tubules    2.6 Larval Fat Body    1.4 Larval Salivary Gland    1.6 Larval Trachea    1.15 Larval Carcass    1.6 Adult Head    5.3 Adult Eye    3.5 Adult Brain    1.2 Adult Thoracic-Abdominal Ganglion    3.1 Adult Crop    3.5 Adult Midgut    7.1 Adult Hindgut    2.9 Adult Malpighian Tubules    1.3 Adult Fat Body    1.4 Adult Salivary Gland    3.8 Adult Heart    0.675 Adult VirginFemale Spermatheca    0.8 Adult InseminatedFemale Spermatheca    0.9 Adult Ovary    1.5 Adult Testis    8.4 Adult Male Accessory Gland    6.2 Adult Carcass    4.8 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    8.4 Larval Midgut    1 Larval Hindgut    1 Larval Malpighian Tubules    2.6 Larval Fat Body    1.4 Larval Salivary Gland    1.6 Larval Trachea    1.15 Larval Carcass    1.6 Adult Head    5.3 Adult Eye    3.5 Adult Brain    1.2 Adult Thoracic-Abdominal Ganglion    3.1 Adult Crop    3.5 Adult Midgut    7.1 Adult Hindgut    2.9 Adult Malpighian Tubules    1.3 Adult Fat Body    1.4 Adult Salivary Gland    3.8 Adult Heart    0.675 Adult VirginFemale Spermatheca    0.8 Adult InseminatedFemale Spermatheca    0.9 Adult Ovary    1.5 Adult Testis    8.4 Adult Male Accessory Gland    6.2 Adult Carcass    4.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    8.4 Larval Midgut    1 Larval Hindgut    1 Larval Malpighian Tubules    2.6 Larval Fat Body    1.4 Larval Salivary Gland    1.6 Larval Trachea    1.15 Larval Carcass    1.6 Adult Head    5.3 Adult Eye    3.5 Adult Brain    1.2 Adult Thoracic-Abdominal Ganglion    3.1 Adult Crop    3.5 Adult Midgut    7.1 Adult Hindgut    2.9 Adult Malpighian Tubules    1.3 Adult Fat Body    1.4 Adult Salivary Gland    3.8 Adult Heart    0.675 Adult VirginFemale Spermatheca    0.8 Adult InseminatedFemale Spermatheca    0.9 Adult Ovary    1.5 Adult Testis    8.4 Adult Male Accessory Gland    6.2 Adult Carcass    4.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    8.4 Larval Midgut    1 Larval Hindgut    1 Larval Malpighian Tubules    2.6 Larval Fat Body    1.4 Larval Salivary Gland    1.6 Larval Trachea    1.15 Larval Carcass    1.6 Adult Head    5.3 Adult Eye    3.5 Adult Brain    1.2 Adult Thoracic-Abdominal Ganglion    3.1 Adult Crop    3.5 Adult Midgut    7.1 Adult Hindgut    2.9 Adult Malpighian Tubules    1.3 Adult Fat Body    1.4 Adult Salivary Gland    3.8 Adult Heart    0.675 Adult VirginFemale Spermatheca    0.8 Adult InseminatedFemale Spermatheca    0.9 Adult Ovary    1.5 Adult Testis    8.4 Adult Male Accessory Gland    6.2 Adult Carcass    4.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    5.3   NA  Eye    3.5   NA  Brain    1.2   8.4  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    3.1   NA  Crop    3.5   1  Midgut    7.1   1  Hindgut    2.9   2.6  Malpighian Tubules    1.3   1.4  Fat Body    1.4   1.6  Salivary Gland    3.8   NA  Heart    0.675   1.15  Trachea    NA   NA  VirginFemale Spermatheca    0.8   NA  InseminatedFemale Spermatheca    0.9   NA  Ovary    1.5   NA  Testis    8.4   NA  Male Accessory Gland    6.2   1.6  Carcass    4.8 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_24
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0260933
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive rempAk12913 viable rempAe02928 viable, with Scer\GAL4pnr-MD237 rempAGD7400 Sterility Allele fertile rempAe02928 Other Phenotypes Allele auditory perception defective | recessive rempA1 behavior defective | recessive rempA1 locomotor behavior defective | recessive rempA1 neurophysiology defective | adult stage rempA1 rempA21Ci-1 rempAk12913 neurophysiology defective | adult stage (with rempA21Ci-1) rempAk12913 neurophysiology defective | adult stage (with rempAk12913) rempA21Ci-1 uncoordinated | recessive rempA1 Phenotype manifest in Allele adult antennal nerve rempA1 leg rempA1 scolopidial cilium & Johnston's organ rempA1 rempAk12913 scolopidial cilium & pentascolopidial chordotonal organ rempA1 wing rempA1
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of rempA Class Mutagen Stocks Known lesion rempAe02928 piggyBac transposase 2 -- rempA1 0 Yes rempA21Ci-1 0 Yes rempAk12913 0 Yes rempAunspecified 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of rempA Class Mutagen Stocks Known lesion rempAGD7400 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes rempAKK100864 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes rempAScer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes rempAT:Avic\GFP-YFP.Venus in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)BSC16 (Lee et al., 2008) Ts(YSt;2Rt)L124 (Lee et al., 2008)
Not disrupted in	Df(2L)al (Lee et al., 2008) Df(2L)BSC4 (Lee et al., 2008)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK100864} NA characterization construct P{rempA+-YFP} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}rempAe02928 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
	There is no information supporting a cellular component term for this gene. (Based on a review of available data before: 2006)
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cilium assembly inferred from expression pattern (Avidor-Reiss et al., 2004) intraflagellar transport inferred from mutant phenotype (Lee et al., 2008) nonmotile primary cilium assembly inferred from mutant phenotype (Lee et al., 2008) sensory perception of sound inferred from mutant phenotype (Eberl et al., 2000, Lee et al., 2008)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
binding inferred from electronic annotation with InterPro:IPR011990 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
cilium assembly inferred from sequence model (Avidor-Reiss et al., 2004) nonmotile primary cilium assembly inferred from sequence or structural similarity with Oseg1 (Avidor-Reiss et al., 2004)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions rempA allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0260933 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33230
Orthologs
Genome-wide drosophilid orthologs	Dana\GF24697 Dere\GG24641 Dgri\GH10508 Dmoj\GI18026 Dper\GL19255 Dpse\GA11225 Dsim\GD22951 Dvir\GJ19704 Dwil\GK24432 Dyak\GE16040
Curated drosophilid orthologs	Dpse\GA11225
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL002943-PA Aedes aegypti (mosquito) AGAP000686-PA Anopheles gambiae (mosquito) XP_001122512.1 Apis mellifera (honey bee) XP_001946444.1 Acyrthosiphon pisum (pea aphid) 92618 Batrachochytrium dendrobatidis (chytrid fungus) 118626 Branchiostoma floridae (lancelet) BGIBMGA007264-PA Bombyx mori (silk worm) ENSBTAP00000044615 Bos taurus (bovine) CBP20705 Caenorhabditis briggsae (nematode) CE42072 Caenorhabditis elegans (worm) ENSCINP00000019435 Ciona intestinalis (sea squirt) JA00902 Caenorhabditis japonica (nematode) CPIJ011749 Culex pipens (mosquito) ENSCPOP00000002994 Cavia porcellus (guinea pig) 192205 Chlamidomonas reinhardtii (green alga) 114177 Capitella spl (polychaete worm) ENSDARP00000046545 Danio rerio (zebra fish) ENSECAP00000007499 Equus caballus (horse) ENSGACP00000011140 Gymnopilus aculeatus (mushroom) ENSGALP00000015148 Gallus gallus (chicken) GL50803_17251 Giardia lamblia (flagellated protozoan) 92025 Hypsipyla robusta (cedar shoot borer) ENSP00000380562 Homo sapiens (human) ISCW008642-PA Ixodes scapularis (deer tick) 223604 Lottia gigantea (owl limpet) LmjF32.0310 Leishmania major (virus) 17802 Monocosta brevicollis (choanoflagellate) ENSMODP00000020197 Monodelphis domestica (gray opossum) ENSMMUP00000004845 Macaca mulatta (rhesus monkey) ENSMUSP00000024983 Mus musculus (house mouse) 122551 Nematostella vectensis (starlet anemone) ENSORLP00000009306 Oryzias latipes (japanese killifish) PHUM001701-PA Pediculus humanus (human body louse) PP05219 Pristionchus pacificus (nematode) 75973 Physcomitrella patens (moss) ENSPPYP00000007875 Pongo pygmaeus (orangutan) 76197 Phytophthora ramorum (sudden oak death pathogen) 134255 Phytophthora sojae (root rot pathogen) ENSPTRP00000012987 Pan troglodytes (chimpanzee) ENSRNOP00000022063 Rattus norvegicus (norway rat) Smp_163250 Schistosoma mansoni (trematode parasite) XP_001192126.1 Strongylocentrotus purpuratus (purple sea urchin) 60914 Trichoplax adhaerens (metazoa) XP_973773.2 Tribolium castaneum (red flour beetle) Tc00.1047053506215.19 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000015787 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000037977 Takifugu rubripes (pufferfish Takifugu) 3701.m00192 Tetrahymena thermophila (ciliate protozoa) 97007.m00130 Trichomonas vaginalis (parasitic flagellated protozoan) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17065 NV50168 LH18752 ISCW008642 FBgn0233591 FBgn0226392 FBgn0206846 FBgn0194345 FBgn0171572 FBgn0171571 JGI_V11_11231 FBgn0071279 FBgn0156854 FBgn0140766 FBgn0117989 FBgn0116773 FBgn0101690 CPIJ011749 BGIBMGA007264 ACYPI006166 GB10317 AGAP000686 AAEL002943 PHUM275030 GLEAN_06692
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	18098 w1118; PBac{RB}rempAe02928
Harvard	- PBac{RB}rempAe02928
VDRC	v103424 P{KK100864}VIE-260B v31575 w1118 P{GD7400}v31575
Genomic Clones ( 1 )
	BACR48E08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 2 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP14838 LP14662
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0260933 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33230 249523
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Oseg3 CG11838 (Avidor-Reiss et al., 2004)
Source for database merge of	Source for merge of: rempA Oseg3 (Lee et al., 2008)
Additional comments
Other Comments
	rempA mutant phenotypes are consistent with it being required for normal retrograde intraflagellar transport in developing chordotonal cilia. rempA is also required for the development of the ciliary dilation in the cilia of the chordotonal organs. (Lee et al., 2008) Mutation causes a reduction in both the mechanoreceptor potential (MRP) amplitude and the transepithelial potential (TEP) value. Mutations cause adult inviability due to severe uncoordination. (Kernan et al., 1994)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_134686 NM_205886 RefSeq (Proteins) • NP_608530 NP_995608 DDBJ / EMBL / GenBank • AAF51483 AAS64635 AAX33508 BT021360 Entrez Gene - A searchable database of RefSeq genes. • 33230 UniProtKB/TrEMBL • Q5BI64 Q7KTZ4 Q9VPR0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • WD40/YVTN repeat-like-containing domain (IPR015943) WD40-repeat-containing domain (IPR017986) WD40 repeat (IPR001680) WD40 repeat-like-containing domain (IPR011046) Tetratricopeptide-like helical (IPR011990)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0260933 DRSC - Results from RNAi screens. • FBgn0260933 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0260933 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0260933 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33230 249523 InParanoid A subset of ortholog calls from InParanoid. • AAEL002943-PA Aedes aegypti (mosquito) AGAP000686-PA Anopheles gambiae (mosquito) XP_001122512.1 Apis mellifera (honey bee) XP_001946444.1 Acyrthosiphon pisum (pea aphid) 92618 Batrachochytrium dendrobatidis (chytrid fungus) 118626 Branchiostoma floridae (lancelet) BGIBMGA007264-PA Bombyx mori (silk worm) ENSBTAP00000044615 Bos taurus (bovine) CBP20705 Caenorhabditis briggsae (nematode) CE42072 Caenorhabditis elegans (worm) ENSCINP00000019435 Ciona intestinalis (sea squirt) JA00902 Caenorhabditis japonica (nematode) CPIJ011749 Culex pipens (mosquito) ENSCPOP00000002994 Cavia porcellus (guinea pig) 192205 Chlamidomonas reinhardtii (green alga) 114177 Capitella spl (polychaete worm) ENSDARP00000046545 Danio rerio (zebra fish) ENSECAP00000007499 Equus caballus (horse) ENSGACP00000011140 Gymnopilus aculeatus (mushroom) ENSGALP00000015148 Gallus gallus (chicken) GL50803_17251 Giardia lamblia (flagellated protozoan) 92025 Hypsipyla robusta (cedar shoot borer) ENSP00000380562 Homo sapiens (human) ISCW008642-PA Ixodes scapularis (deer tick) 223604 Lottia gigantea (owl limpet) LmjF32.0310 Leishmania major (virus) 17802 Monocosta brevicollis (choanoflagellate) ENSMODP00000020197 Monodelphis domestica (gray opossum) ENSMMUP00000004845 Macaca mulatta (rhesus monkey) ENSMUSP00000024983 Mus musculus (house mouse) 122551 Nematostella vectensis (starlet anemone) ENSORLP00000009306 Oryzias latipes (japanese killifish) PHUM001701-PA Pediculus humanus (human body louse) PP05219 Pristionchus pacificus (nematode) 75973 Physcomitrella patens (moss) ENSPPYP00000007875 Pongo pygmaeus (orangutan) 76197 Phytophthora ramorum (sudden oak death pathogen) 134255 Phytophthora sojae (root rot pathogen) ENSPTRP00000012987 Pan troglodytes (chimpanzee) ENSRNOP00000022063 Rattus norvegicus (norway rat) Smp_163250 Schistosoma mansoni (trematode parasite) XP_001192126.1 Strongylocentrotus purpuratus (purple sea urchin) 60914 Trichoplax adhaerens (metazoa) XP_973773.2 Tribolium castaneum (red flour beetle) Tc00.1047053506215.19 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000015787 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000037977 Takifugu rubripes (pufferfish Takifugu) 3701.m00192 Tetrahymena thermophila (ciliate protozoa) 97007.m00130 Trichomonas vaginalis (parasitic flagellated protozoan) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33230 modMine - Data generated by the modENCODE project. • FBgn0260933 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17065 NV50168 LH18752 ISCW008642 FBgn0233591 FBgn0226392 FBgn0206846 FBgn0194345 FBgn0171572 FBgn0171571 JGI_V11_11231 FBgn0071279 FBgn0156854 FBgn0140766 FBgn0117989 FBgn0116773 FBgn0101690 CPIJ011749 BGIBMGA007264 ACYPI006166 GB10317 AGAP000686 AAEL002943 PHUM275030 GLEAN_06692
Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym	CG11838 (Lee et al., 2008, Keleman et al., 2009.8.5) CHE-11 (Avidor-Reiss et al., 2004) Che-11 (Jekely, 2006) IFT40 (Lee et al., 2008) IFT140 (Lee et al., 2007, Jekely, 2006) OSEG (Fliegauf and Omran, 2006) oseg3 (Lee et al., 2008, Lee et al., 2008) OSEG3 (Avidor-Reiss et al., 2004, Jekely, 2006) Oseg3   remp (Ernstrom and Chalfie, 2002, Kernan et al., 1994, ) rempA (Lee et al., 2008, Lee et al., 2008, Lee et al., 2007, Wasbrough et al., 2010) REMPA (Lee et al., 2010)
Name Synonym	Oseg3   reduced mechanoreceptor potential A (Lee et al., 2008, ) reduced mechanoreceptor potentials (Kernan et al., 1994) reduced mechanoreceptor potentials A (Eberl et al., 2000)
Secondary FlyBase IDs
	FBgn0016923 FBgn0031262
References ( 20 )
Research paper	Lee et al., 2010, PLoS ONE 5(6): e11012 Drosophila TRPN(=NOMPC) channel localizes to the distal end of mechanosensory cilia. [FBrf0210994] Lee et al., 2008, Curr. Biol. 18(24): 1899--1906 An IFT-A protein is required to delimit functionally distinct zones in mechanosensory cilia. [FBrf0206532] Avidor-Reiss et al., 2004, Cell 117(4): 527--539 Decoding cilia function; defining specialized genes required for compartmentalized cilia biogenesis. [FBrf0174448] Eberl et al., 2000, J. Neurosci. 20(16): 5981--5988 Genetically similar transduction mechanisms for touch and hearing in Drosophila. [FBrf0129796] Kernan et al., 1994, Neuron 12(6): 1195--1206 Genetic dissection of mechanosensory transduction: mechanoreception-defective mutants of Drosophila. [FBrf0073546]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Wasbrough et al., 2010, J. Proteomics 73(11): Supplemental Table 1. Mass spectrometry data. [FBrf0213252] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Lee et al., 2008, Curr. Biol. 18(24): Supplemental Data. [FBrf0207609]
Review	Fliegauf and Omran, 2006, Trends Genet. 22(5): 241--245 Novel tools to unravel molecular mechanisms in cilia-related disorders. [FBrf0198595] Jekely, 2006, BioEssays 28(2): 191--198 [FBrf0198743] Ernstrom and Chalfie, 2002, A. Rev. Genet. 36: 411--453 Genetics of sensory mechanotransduction. [FBrf0158719] Kernan and Zuker, 1995, Curr. Opin. Neurobiol. 5(4): 443--448 Genetic approaches to mechanosensory transduction. [FBrf0084087]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Bloomington Drosophila Stock Center, 2004.11.6, Exelixis insertion alleles that are not in FlyBase. Exelixis insertion alleles that are not in FlyBase. [FBrf0179797] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
Abstract	Lee et al., 2007, A. Dros. Res. Conf. 48: 601A The intraflagellar transport protein REMPA/IFT140 is a component of the chordotonal ciliary dilation. [FBrf0197899]
FlyBase analysis	FlyBase Curators, 2002-, Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. [FBrf0159398]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]