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General Information
Symbol
Dmel\par-1
Species
D. melanogaster
Name
par-1
Annotation Symbol
CG8201
Feature Type
FlyBase ID
FBgn0260934
Gene Model Status
Stock Availability
Enzyme Name (EC)
[Tau protein] kinase (2.7.11.26)
Gene Snapshot
par-1 (par-1) encodes a protein kinase involved in multiple processes, including microtubule cytoskeleton organization, axis specification and cell polarity. It regulates hippo signaling and osk mRNA localization. [Date last reviewed: 2019-06-13]
Also Known As
l(2)k06323, MARK, dMARK, dPAR-1, l(2)27C1
Key Links
Genomic Location
Cytogenetic map
Sequence location
2R:19,456,170..19,485,686 [+]
Recombination map
2-89
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
-
Catalytic Activity (EC)
Experimental Evidence
ATP + [tau protein] = ADP + [tau protein] phosphate (2.7.11.26)
Predictions / Assertions
ATP + [tau protein] = ADP + [tau protein] phosphate (2.7.11.26)
Summaries
Gene Group (FlyBase)
CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASES -
The Calcium/Calmodulin-dependent kinase family are serine/threonine kinases which, in general, prefer substrates containing basic residues. Many, but not all, members are regulated by calcium or calmodulin. (Adapted from FBrf0132098).
Pathway (FlyBase)
Negative Regulators of Hippo Signaling Pathway -
The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Negative regulators of the pathway promote the nuclear accumulation of yki, enhancing yki-mediated transcriptional regulation and the expression of genes that positively regulate tissue growth (Adapted from FBrf0224870).
Summary (Interactive Fly)
serine/threonine kinase involved in cell polarization during asymmetric cell division - synaptic active zone proteins are transported via mechanisms regulated by Par-1 kinase
Gene Model and Products
Number of Transcripts
11
Number of Unique Polypeptides
11

Please see the GBrowse view of Dmel\par-1 or the JBrowse view of Dmel\par-1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Shares 5' UTR with upstream gene.
gene_with_stop_codon_read_through ; SO:0000697
Gene model reviewed during 5.44
Stop-codon suppression (UGA) postulated; FBrf0216884.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.48
Gene model includes transcripts encoding non-overlapping portions of the full CDS.
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0086450
4827
938
FBtr0086457
4868
993
FBtr0100390
4858
833
FBtr0301503
4849
1141
FBtr0100393
3321
357
FBtr0301504
3918
1046
FBtr0301505
4840
827
FBtr0301506
4990
1058
FBtr0330244
6079
951
FBtr0330243
3863
832
FBtr0330245
4827
1170
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0085646
101.5
938
10.35
FBpp0085653
107.8
993
10.58
FBpp0099804
89.3
833
10.43
FBpp0290718
124.6
1141
10.33
FBpp0099807
38.6
357
10.86
FBpp0290719
113.7
1046
10.44
FBpp0290720
88.5
827
10.42
FBpp0290721
114.9
1058
10.49
FBpp0303277
102.2
951
10.22
FBpp0303276
89.1
832
10.42
FBpp0303278
126.4
1170
10.26
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
A large number of transcripts are produced from the par-1 gene by the use of alternative promoters, multiple 3' ends and additional alternative splicing events. The predicted proteins range from 833-1130 amino acids.
External Data
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\par-1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (31 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441
(assigned by InterPro )
inferred from biological aspect of ancestor with PANTHER:PTN002519176
(assigned by GO_Central )
inferred from sequence or structural similarity with WB:WBGene00003916
inferred from biological aspect of ancestor with PANTHER:PTN000680111
(assigned by GO_Central )
Biological Process (21 terms)
Terms Based on Experimental Evidence (17 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from physical interaction with FLYBASE:sav; FB:FBgn0053193
inferred from physical interaction with FLYBASE:hpo; FB:FBgn0261456
inferred from direct assay
Terms Based on Predictions or Assertions (7 terms)
CV Term
Evidence
References
Cellular Component (7 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN002519176
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
par-1 protein is initially ubiquitously expressed in germline cells, but becomes localized to the presumptive oocyte after fusome disappearance, during oocyte specification. During oocyte polarization par-1 protein relocalizes from the anterior to the posterior of the developing oocyte. In stage 5 oocytes FBgn0260934:par-1 becomes tightly associated with the posterior cell cortex and does not overlap with FBgn0000163:baz @ protein.
par-1 protein localizes cortically within follicle cells at early stages of oogenesis. It is restricted to the basolateral membrane domain of the columnar epithelium in stage 10 egg chambers. The earliest germ line staining is in the fusome in the germarium. par-1 protein then localizes to the ring canals and the cortical cytoskeleton of the nurse cells. No asymmetric localization of par-1 protein is observed in the oocyte during stages 1-8 but in stage 9, a transient enrichment is observed in the anterior of the oocyte. par-1 protein then becomes progressively more concentrated at the posterior pole during stages 9 and 10.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\par-1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 39 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 45 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of par-1
Transgenic constructs containing regulatory region of par-1
Deletions and Duplications ( 6 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
centrosome & oocyte | germ-line clone
follicle cell & microtubule | somatic clone
germarium region 2b & microtubule | germ-line clone
microtubule & oocyte | posterior
oocyte & microtubule (with par-1k06323)
oocyte & microtubule (with par-1W3)
oocyte & pericentriolar material
photoreceptor cell & neuron, with Scer\GAL4elav-C155
photoreceptor cell & neuron, with Scer\GAL4hs.2sev
photoreceptor cell & neuron, with Scer\GAL4hs.PB
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (23)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
12 of 15
Yes
Yes
 
11 of 15
No
Yes
 
10 of 15
No
Yes
 
10 of 15
No
Yes
 
2 of 15
No
No
 
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (40)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
13 of 15
Yes
Yes
11 of 15
No
Yes
10 of 15
No
Yes
10 of 15
No
Yes
3 of 15
No
Yes
3 of 15
No
No
2 of 15
No
Yes
2 of 15
No
Yes
2 of 15
No
Yes
2 of 15
No
Yes
2 of 15
No
Yes
2 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
Yes
2 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (27)
10 of 13
Yes
Yes
8 of 13
No
Yes
8 of 13
No
Yes
5 of 13
No
Yes
2 of 13
No
Yes
2 of 13
No
No
2 of 13
No
Yes
2 of 13
No
Yes
2 of 13
No
Yes
2 of 13
No
No
2 of 13
No
Yes
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (10)
5 of 12
Yes
Yes
4 of 12
No
Yes
4 of 12
No
Yes
2 of 12
No
No
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
Danio rerio (Zebrafish) (20)
12 of 15
Yes
Yes
11 of 15
No
Yes
9 of 15
No
Yes
8 of 15
No
Yes
7 of 15
No
Yes
6 of 15
No
Yes
5 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (21)
12 of 15
Yes
Yes
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (14)
2 of 9
Yes
Yes
1 of 9
No
No
1 of 9
No
Yes
1 of 9
No
No
1 of 9
No
Yes
1 of 9
No
Yes
1 of 9
No
No
1 of 9
No
No
1 of 9
No
No
1 of 9
No
No
1 of 9
No
Yes
1 of 9
No
Yes
1 of 9
No
No
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (11)
6 of 15
Yes
Yes
5 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (9)
4 of 12
Yes
Yes
2 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091901GX )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila sechellia
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150417 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Musca domestica
House fly
Musca domestica
House fly
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0CMH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0CKI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0D1E )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (13)
4 of 10
3 of 10
3 of 10
2 of 10
2 of 10
2 of 10
2 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 6 )
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    Negative Regulators of Hippo Signaling Pathway -
    The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Negative regulators of the pathway promote the nuclear accumulation of yki, enhancing yki-mediated transcriptional regulation and the expression of genes that positively regulate tissue growth (Adapted from FBrf0224870).
    External Data
    Linkouts
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2R
    Recombination map
    2-89
    Cytogenetic map
    Sequence location
    2R:19,456,170..19,485,686 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    56D9-57D12
    Limits computationally determined from genome sequence between P{lacW}l(2)k00705k00705&P{lacW}mei-W68k05603 and P{EP}CG11007EP736; Left limit from (method unavailable) (FBrf0108422) Right limit from (method unavailable) (FBrf0108422)
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    56D8-56D11
    (determined by in situ hybridisation)
    56F9-57D12
    (determined by deficiency mapping, details unspecified).
    Experimentally Determined Recombination Data
    Location
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (24)
    Genomic Clones (31)
    cDNA Clones (159)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of
    Source for merge of: par-1 CG11960
    Source for merge of: par-1 BcDNA:RH48823
    Source for merge of: par-1 l(2)27C1
    Source for merge of: par-1 anon-WO0210402.19
    Additional comments
    One or more of the processed transcripts for this gene share(s) untranslated sequences with a transcript of an adjacent gene, but encode(s) a single open reading frame (ORF). The non-overlapping ORFs that share untranslated sequences are represented by par-1 and mei-W68.
    Source for merge of par-1 anon-WO0210402.19 was sequence comparison ( date:051113 ).
    Other Comments
    RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a greater than three-fold increase in AttA activity in response to heat-killed E.coli after ecdysone treatment in S2 cells.
    When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of G2/M phase cells, an increase in cell size, a decrease in mitotic index and a whole range of mitotic abnormalities are seen.
    dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
    RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: reduced F-actin and altered cell shape. Kc167 cells show change from round to spindle-shaped, with the formation of F-actin puncta and microtubule extensions.
    par-1 protein phosphorylates osk protein and par-1 is required for the accumulation of osk protein.
    par-1 appears to act on the cytoskeleton to affect polarisation within the oocyte in conjunction with BicD, egl and dynein.
    par-1 is required early in the germline for organisation of the microtubule cytoskeleton and subsequent oocyte determination. It has a second role late in oogenesis in axis determination.
    par-1 is required for the maintenance of oocyte identity.
    Loss of par-1 function disrupts pole cell formation and abdominal patterning in the embryo. These defects arise from a disorganisation of the oocyte microtubule cytoskeleton.
    par-1 is maternally required for gametogenesis.
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 140 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    FlyMine - An integrated database for Drosophila genomics
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Linkouts
    ApoDroso - Functional genomic database for photoreceptor development, survival and function
    BioGRID - A database of protein and genetic interactions.
    DPiM - Drosophila Protein interaction map
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (31)
    Reported As
    Symbol Synonym
    BcDNA:RH48823
    CG16701
    CG30132
    anon-WO0210402.19
    par-1
    (Baskar et al., 2019, Kockel et al., 2019, Chiku et al., 2018, Saito et al., 2018, Takeda et al., 2018, Herzmann et al., 2017, Laflamme et al., 2017, Song et al., 2017, Gene Disruption Project members, 2016-, Nashchekin et al., 2016, Chittaranjan et al., 2015, Gailite et al., 2015, Gene Disruption Project members, 2015-, Grotewiel and Bettinger, 2015, Jiang et al., 2015, Venkei and Yamashita, 2015, Zang et al., 2015, Ashwal-Fluss et al., 2014, Claret et al., 2014, Eliazer et al., 2014, Merlo et al., 2014, Morais-de-Sá et al., 2014, Sopko et al., 2014, Taniguchi et al., 2014, Bai et al., 2013, de Celis et al., 2013.9.11, Geisbrecht et al., 2013, Huang et al., 2013, Kwon et al., 2013, Vaque et al., 2013, Gistelinck et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Nakano and Takashima, 2012, Wang et al., 2012, Yuan et al., 2012, Zhao et al., 2012, Abruzzi et al., 2011, Ambegaokar and Jackson, 2011, Friedman et al., 2011, Hu et al., 2011, Jungreis et al., 2011, King et al., 2011, Parton et al., 2011, Becalska and Gavis, 2010, Doerflinger et al., 2010, Fichelson et al., 2010, Gonsalvez et al., 2010, Wasbrough et al., 2010, Amin et al., 2009, Davidson et al., 2009, Dworkin et al., 2009, Simons et al., 2009, Lighthouse et al., 2008, McDonald et al., 2008, Coutelis and Ephrussi, 2007, Ferjoux et al., 2007, Wang et al., 2007, Zhang et al., 2007, Zimyanin et al., 2007, Zimyanin et al., 2007, Lin et al., 2006, Munro et al., 2006, Gotta, 2005, Wiggin et al., 2005, Stanyon et al., 2004)
    Name Synonyms
    ELKL motif kinase
    Par-1 protein kinase
    lethal (2) 27C1
    par-1
    Secondary FlyBase IDs
    • FBgn0026193
    • FBgn0022139
    • FBgn0034448
    • FBgn0034449
    • FBgn0034450
    • FBgn0050131
    • FBgn0050132
    • FBgn0061180
    • FBgn0064805
    • FBgn0065111
    • FBgn0026655
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (302)