FB2021_01, released Feb 18, 2021

Gene: Dmel\bond

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General Information
Symbol
Dmel\bond
Species
D. melanogaster
Name
james bond
Annotation Symbol
CG6921
Feature Type
protein_coding_gene
FlyBase ID
FBgn0260942
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Snapshot
james bond (bond) encodes a member of the Elov1 family of enzymes that function as very long chain fatty acid elongases. It contributes to sperm generation and the production of the male sex pheromone CH503 in the ejaculatory bulb. [Date last reviewed: 2019-02-28]
Other Summaries
Key Links
Genomic Location
Cytogenetic map
94B4-94B4
Sequence location
3R:22,550,680..22,556,494 [+]
Recombination map

3-75

RefSeq locus
NT_033777 REGION:22550680..22556494
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (16 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables fatty acid elongase activity
inferred from genetic interaction with SGD:S000000630,SGD:S000004364
(Szafer-Glusman et al., 2008)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables fatty acid elongase activity
inferred from biological aspect of ancestor with PANTHER:PTN000125390
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (13 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
involved_in actomyosin contractile ring assembly
inferred from mutant phenotype
(Giansanti et al., 2004)
involved_in fatty acid elongation
inferred from genetic interaction with SGD:S000000630,SGD:S000004364
(Szafer-Glusman et al., 2008)
involved_in male meiosis cytokinesis
inferred from mutant phenotype
(Szafer-Glusman et al., 2008)
involved_in meiosis I cytokinesis
inferred from mutant phenotype
(Giansanti et al., 2004)
involved_in meiosis II cytokinesis
inferred from mutant phenotype
(Giansanti et al., 2004)
involved_in meiotic spindle organization
inferred from mutant phenotype
(Szafer-Glusman et al., 2008)
involved_in pheromone biosynthetic process
inferred from mutant phenotype
(Ng et al., 2015)
involved_in spindle assembly
inferred from mutant phenotype
(Giansanti et al., 2004)
involved_in very long-chain fatty acid biosynthetic process
inferred from genetic interaction with SGD:S000000630,SGD:S000004364
(Szafer-Glusman et al., 2008)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
involved_in fatty acid elongation, monounsaturated fatty acid
inferred from biological aspect of ancestor with PANTHER:PTN000125390
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in fatty acid elongation, polyunsaturated fatty acid
inferred from biological aspect of ancestor with PANTHER:PTN000125390
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in fatty acid elongation, saturated fatty acid
inferred from biological aspect of ancestor with PANTHER:PTN000125390
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in sphingolipid biosynthetic process
inferred from biological aspect of ancestor with PANTHER:PTN000125390
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in very long-chain fatty acid biosynthetic process
inferred from biological aspect of ancestor with PANTHER:PTN000125390
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with HGNC:14415
(Szafer-Glusman et al., 2008)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in integral component of endoplasmic reticulum membrane
inferred from biological aspect of ancestor with PANTHER:PTN000125390
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in integral component of membrane
inferred from sequence model
(Szafer-Glusman et al., 2008)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
FATTY ACID ELONGASES -
Fatty acid elongases are conserved from yeast to mammals and mediate elongation of fatty acids into very-long-chain fatty acids (VLCFAs, i.e. with acyl chains of 18 carbon atoms or longer). They are bound to the endoplasmic reticulum membrane where they are believed to perform the first step (condensation) in the elongation cycle. VLCFAs are most commonly found in sphingolipids and are essential for sphingolipid formation and function. (Adapted from PMID:16564093.)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\bond for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
bond-RA
FBtr0084262
NM_170022
1627
322
bond-RB
FBtr0084261
NM_142805
1605
322
bond-RC
FBtr0084263
NM_170023
1503
322
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
bond-PA
FBpp0083655
36.9
322
10.02
NP_732761
AAF56018
bond-PB
FBpp0083654
36.9
322
10.02
NP_651062
AAN13910
bond-PC
FBpp0083656
36.9
322
10.02
NP_732762
AAN13911
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

322 aa isoforms: bond-PA, bond-PB, bond-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\bond using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | male
spermatocyte
(Szafer-Glusman et al., 2008)
male accessory gland
(Ng et al., 2015)
embryonic stage
embryonic/larval oenocyte precursor
(Szafer-Glusman et al., 2008)
corpus allatum
(Szafer-Glusman et al., 2008)
embryonic hindgut
(Szafer-Glusman et al., 2008)
oogenesis stage S9 -- S10
egg chamber
(Szafer-Glusman et al., 2008)
embryonic stage 9 -- 10
dorsal ectoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
corpus allatum primordium
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
large intestine primordium

Comment: reported as large intestine specific anlage

(Fisher et al., 2012)
salivary gland duct primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic dorsal apodeme
(Fisher et al., 2012)
embryonic foregut
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic large intestine
(Fisher et al., 2012)
embryonic proventriculus
(Fisher et al., 2012)
embryonic proventriculus intermediate layer
(Fisher et al., 2012)
embryonic salivary gland duct
(Fisher et al., 2012)
embryonic/larval corpus allatum
(Fisher et al., 2012)
embryonic/larval oenocyte
(Fisher et al., 2012)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | male
male organism
(Ng et al., 2015)
adult head

Comment: RB and RC isoforms

(Ng et al., 2015)
testis
(Ng et al., 2015)
male accessory gland
(Ng et al., 2015)
ejaculatory bulb

Comment: RB and RC isoforms

(Ng et al., 2015)
adult stage | female
female organism
(Ng et al., 2015)
female reproductive system

Comment: RB isoform

(Ng et al., 2015)
Additional Descriptive Data

bond transcripts were observed in spermatocytes but not in spermatogonia. In embryos, they were observed in groups of cells that give rise to steroid-derived molecules such as oenocytes and corpus alatum. They were also observed in the intesting. In ovaries, they were observed in stage S9 and S10 egg chambers

(Szafer-Glusman et al., 2008)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | male
male accessory gland
(Ng et al., 2015)
testis | restricted
(Ng et al., 2015)
ejaculatory bulb
(Ng et al., 2015)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\bond in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 11 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of bond
Transgenic constructs containing regulatory region of bond
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation
Gene disrupted in
Df(3R)Exel6273
(Ryder, 2004.4.26)
Df(3R)hh
(Giansanti et al., 2004)
Inferred from location
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female sterile
fertile
male sterile
male sterile, with Scer\GAL4bond.PN
Other Phenotypes
Allele
abnormal cytokinesis
abnormal cytokinesis | male
abnormal cytokinesis | male (with bondZ3437)
abnormal cytokinesis | male (with bondZ5274)
abnormal cytokinesis | male (with Df(3R)hh)
abnormal cytokinesis | male | recessive
abnormal meiotic cell cycle | male (with Df(3R)hh)
abnormal meiotic cell cycle | male | recessive
abnormal mitotic cell cycle | male | recessive
Phenotype manifest in
Allele
contractile ring & meiotic cell cycle | male
contractile ring & meiotic cell cycle | male (with Df(3R)hh)
Nebenkern
Nebenkern (with Df(3R)hh)
Nebenkern derivative
spermatid
spermatid & nucleus | supernumerary
spermatid & nucleus | supernumerary (with Df(3R)hh)
spermatocyte
spermatocyte (with bondZ3437)
spermatocyte (with bondZ5274)
spindle & meiotic cell cycle | male
spindle & meiotic cell cycle | male (with Df(3R)hh)
spindle microtubule
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ELOVL1
5 of 15
Yes
No
1  
Hsap\ELOVL7
5 of 15
Yes
No
Hsap\ELOVL2
3 of 15
No
No
Hsap\ELOVL3
3 of 15
No
No
Hsap\ELOVL4
3 of 15
No
No
Hsap\ELOVL5
3 of 15
No
No
Hsap\ELOVL6
2 of 15
No
No
1  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Elovl1
5 of 15
Yes
No
Mmus\Elovl7
5 of 15
Yes
No
Mmus\Elovl2
3 of 15
No
No
Mmus\Elovl3
3 of 15
No
No
Mmus\Elovl4
3 of 15
No
No
Mmus\Elovl5
3 of 15
No
No
Mmus\Elovl6
1 of 15
No
No
Rattus norvegicus (Norway rat) (8)
Rnor\Elovl1
5 of 13
Yes
No
Rnor\Elovl7
5 of 13
Yes
No
Rnor\Elovl2
3 of 13
No
No
Rnor\Elovl4
3 of 13
No
No
Rnor\Elovl5
3 of 13
No
No
Rnor\Elovl3
2 of 13
No
No
Rnor\LOC102549542
2 of 13
No
No
Rnor\Elovl6
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (10)
Xtro\elovl1
5 of 12
Yes
No
Xtro\elovl7
4 of 12
No
No
Xtro\elovl2
3 of 12
No
No
Xtro\elovl5
3 of 12
No
No
Xtro\elovl3
2 of 12
No
No
Xtro\elovl4
2 of 12
No
No
Xtro\elovl6
2 of 12
No
No
Xtro\LOC101732387
2 of 12
No
Yes
Xtro\LOC101733189
2 of 12
No
Yes
Xtro\LOC101731836
1 of 12
No
No
Danio rerio (Zebrafish) (13)
Drer\elovl1a
5 of 15
Yes
No
Drer\elovl1b
5 of 15
Yes
No
Drer\elovl7a
5 of 15
Yes
No
Drer\elovl7b
5 of 15
Yes
No
Drer\elovl2
3 of 15
No
No
Drer\elovl4a
3 of 15
No
No
Drer\elovl4b
3 of 15
No
No
Drer\elovl5
3 of 15
No
No
Drer\elovl8a
3 of 15
No
No
Drer\elovl8b
3 of 15
No
No
Drer\elovl6
2 of 15
No
No
Drer\elovl6l
2 of 15
No
No
Drer\zgc:92749
2 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (9)
Cele\elo-9
3 of 15
Yes
No
Cele\elo-1
2 of 15
No
No
Cele\elo-2
2 of 15
No
No
Cele\elo-3
2 of 15
No
No
Cele\elo-4
2 of 15
No
No
Cele\elo-5
2 of 15
No
No
Cele\elo-6
2 of 15
No
No
Cele\elo-7
2 of 15
No
No
Cele\elo-8
2 of 15
No
No
Arabidopsis thaliana (thale-cress) (4)
Atha\AT3G06460
4 of 9
Yes
Yes
Atha\AT3G06470
3 of 9
No
No
Atha\HOS3-1
2 of 9
No
No
Atha\AT1G75000
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\ELO2
5 of 15
Yes
No
Scer\ELO1
4 of 15
No
No
Scer\ELO3
4 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\SPAC1B2.03c
4 of 12
Yes
No
Spom\SPAC1639.01c
3 of 12
No
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190BT7 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00011771
Drosophila simulans
Dsim\GD20962
Drosophila sechellia
Dsec\GM26443
Drosophila erecta
Dere\GG11145
Drosophila yakuba
Dyak\GE10310
Drosophila ananassae
Dana\GF18858
Drosophila pseudoobscura pseudoobscura
Dpse\GA19958
Drosophila persimilis
Dper\GL13809
Drosophila willistoni
Dwil\GK12817
Drosophila virilis
Dvir\GJ24166
Drosophila mojavensis
Dmoj\GI23310
Drosophila grimshawi
Dgri\GH18330
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091508YV )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17025023
Glossina morsitans
Tsetse fly
Gmor\GMOY008820
Glossina morsitans
Tsetse fly
Gmor\GMOY006243
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_08429
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL002662
Anopheles darlingi
American malaria mosquito
Adar\ADAC009944
Anopheles gambiae
Malaria mosquito
Agam\AGAP008781
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ015711
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ015712
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0A7U )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA000291
Bombyx mori
Silkmoth
Bmor\BGIBMGA010922
Bombyx mori
Silkmoth
Bmor\BGIBMGA010945
Bombyx mori
Silkmoth
Bmor\BGIBMGA010921
Bombyx mori
Silkmoth
Bmor\BGIBMGA000422
Bombyx mori
Silkmoth
Bmor\BGIBMGA010919
Bombyx mori
Silkmoth
Bmor\BGIBMGA010918
Bombyx mori
Silkmoth
Bmor\BGIBMGA000424
Danaus plexippus
Monarch butterfly
Dple\DPOGS211377-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS209918-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS211375-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS215875-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS209934-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS215920-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS215874-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS211376-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL009766
Heliconius melpomene
Postman butterfly
Hmel\HMEL017506
Heliconius melpomene
Postman butterfly
Hmel\HMEL004894
Heliconius melpomene
Postman butterfly
Hmel\HMEL009764
Heliconius melpomene
Postman butterfly
Hmel\HMEL017511
Heliconius melpomene
Postman butterfly
Hmel\HMEL017504
Heliconius melpomene
Postman butterfly
Hmel\HMEL005408
Apis florea
Little honeybee
Aflo\2169865410
Apis florea
Little honeybee
Aflo\2165057682
Apis florea
Little honeybee
Aflo\3385891812
Apis florea
Little honeybee
Aflo\2346876004
Apis florea
Little honeybee
Aflo\2346876196
Apis florea
Little honeybee
Aflo\2346875908
Apis florea
Little honeybee
Aflo\2346876036
Apis mellifera
Western honey bee
Amel\GB51250
Apis mellifera
Western honey bee
Amel\GB54302
Apis mellifera
Western honey bee
Amel\Ame.17083
Apis mellifera
Western honey bee
Amel\LOC550828
Apis mellifera
Western honey bee
Amel\LOC552205
Apis mellifera
Western honey bee
Amel\GB51247
Apis mellifera
Western honey bee
Amel\LOC724552
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20099
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20086
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20093
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20094
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20097
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20096
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20092
Bombus terrestris
Buff-tailed bumblebee
Bter\15205907
Bombus terrestris
Buff-tailed bumblebee
Bter\15205912
Bombus terrestris
Buff-tailed bumblebee
Bter\15205909
Bombus terrestris
Buff-tailed bumblebee
Bter\15205914
Bombus terrestris
Buff-tailed bumblebee
Bter\15205905
Bombus terrestris
Buff-tailed bumblebee
Bter\15205906
Bombus terrestris
Buff-tailed bumblebee
Bter\15205913
Linepithema humile
Argentine ant
Lhum\LH17400
Linepithema humile
Argentine ant
Lhum\LH25667
Linepithema humile
Argentine ant
Lhum\LH17398
Linepithema humile
Argentine ant
Lhum\LH17402
Linepithema humile
Argentine ant
Lhum\LH17397
Linepithema humile
Argentine ant
Lhum\LH25665
Linepithema humile
Argentine ant
Lhum\LH10542
Linepithema humile
Argentine ant
Lhum\LH16891
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000678
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000674
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000681
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000680
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000677
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000679
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00067f
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG018103
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG018116
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG018119
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG018104
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG018114
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG018102
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG018106
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00216
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12941
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12924
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12925
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12923
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10051
Tribolium castaneum
Red flour beetle
Tcas\TC016278
Tribolium castaneum
Red flour beetle
Tcas\TC016280
Tribolium castaneum
Red flour beetle
Tcas\TC034276
Tribolium castaneum
Red flour beetle
Tcas\TC011938
Tribolium castaneum
Red flour beetle
Tcas\TC002898
Tribolium castaneum
Red flour beetle
Tcas\TC010977
Tribolium castaneum
Red flour beetle
Tcas\TC034274
Tribolium castaneum
Red flour beetle
Tcas\TC011937
Tribolium castaneum
Red flour beetle
Tcas\TC016279
Tribolium castaneum
Red flour beetle
Tcas\TC002899
Pediculus humanus
Human body louse
Phum\PHUM381320
Pediculus humanus
Human body louse
Phum\PHUM576950
Pediculus humanus
Human body louse
Phum\PHUM381550
Pediculus humanus
Human body louse
Phum\PHUM494510
Pediculus humanus
Human body louse
Phum\PHUM576820
Pediculus humanus
Human body louse
Phum\PHUM047320
Pediculus humanus
Human body louse
Phum\PHUM381440
Pediculus humanus
Human body louse
Phum\PHUM381330
Rhodnius prolixus
Kissing bug
Rpro\RPRC009588
Rhodnius prolixus
Kissing bug
Rpro\RPRC014612
Rhodnius prolixus
Kissing bug
Rpro\RPRC003658
Rhodnius prolixus
Kissing bug
Rpro\RPRC002656
Rhodnius prolixus
Kissing bug
Rpro\RPRC003507
Rhodnius prolixus
Kissing bug
Rpro\RPRC000545
Cimex lectularius
Bed bug
Clec\CLEC013405
Cimex lectularius
Bed bug
Clec\CLEC005993
Cimex lectularius
Bed bug
Clec\CLEC006019
Cimex lectularius
Bed bug
Clec\CLEC008446
Cimex lectularius
Bed bug
Clec\CLEC013425
Cimex lectularius
Bed bug
Clec\CLEC013428
Cimex lectularius
Bed bug
Clec\CLEC011675
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007931
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI22564
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI55275
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006915
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003344
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005277
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001792
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005018
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002989
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_05767
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_00796
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_15239
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_14342
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_07404
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_07409
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0A3S )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR002556
Strigamia maritima
European centipede
Smar\SMAR002349
Strigamia maritima
European centipede
Smar\SMAR001835
Strigamia maritima
European centipede
Smar\SMAR013293
Strigamia maritima
European centipede
Smar\SMAR002560
Strigamia maritima
European centipede
Smar\SMAR002261
Ixodes scapularis
Black-legged tick
Isca\ISCW003063
Ixodes scapularis
Black-legged tick
Isca\ISCW002252
Ixodes scapularis
Black-legged tick
Isca\ISCW005940
Ixodes scapularis
Black-legged tick
Isca\ISCW015231
Ixodes scapularis
Black-legged tick
Isca\ISCW001194
Ixodes scapularis
Black-legged tick
Isca\ISCW015232
Ixodes scapularis
Black-legged tick
Isca\ISCW001195
Ixodes scapularis
Black-legged tick
Isca\ISCW002256
Ixodes scapularis
Black-legged tick
Isca\ISCW015224
Ixodes scapularis
Black-legged tick
Isca\ISCW011553
Ixodes scapularis
Black-legged tick
Isca\ISCW019368
Ixodes scapularis
Black-legged tick
Isca\ISCW015228
Ixodes scapularis
Black-legged tick
Isca\ISCW015239
Ixodes scapularis
Black-legged tick
Isca\ISCW015237
Ixodes scapularis
Black-legged tick
Isca\ISCW015226
Ixodes scapularis
Black-legged tick
Isca\ISCW013893
Ixodes scapularis
Black-legged tick
Isca\ISCW002250
Ixodes scapularis
Black-legged tick
Isca\ISCW023546
Ixodes scapularis
Black-legged tick
Isca\ISCW022846
Ixodes scapularis
Black-legged tick
Isca\ISCW003894
Ixodes scapularis
Black-legged tick
Isca\ISCW017055
Ixodes scapularis
Black-legged tick
Isca\ISCW003066
Ixodes scapularis
Black-legged tick
Isca\ISCW017283
Ixodes scapularis
Black-legged tick
Isca\ISCW015230
Ixodes scapularis
Black-legged tick
Isca\ISCW009915
Ixodes scapularis
Black-legged tick
Isca\ISCW019366
Ixodes scapularis
Black-legged tick
Isca\ISCW012517
Ixodes scapularis
Black-legged tick
Isca\ISCW023550
Ixodes scapularis
Black-legged tick
Isca\ISCW015238
Ixodes scapularis
Black-legged tick
Isca\ISCW010899
Ixodes scapularis
Black-legged tick
Isca\ISCW019367
Ixodes scapularis
Black-legged tick
Isca\ISCW019365
Ixodes scapularis
Black-legged tick
Isca\ISCW013892
Ixodes scapularis
Black-legged tick
Isca\ISCW003067
Ixodes scapularis
Black-legged tick
Isca\ISCW010858
Ixodes scapularis
Black-legged tick
Isca\ISCW015056
Ixodes scapularis
Black-legged tick
Isca\ISCW003062
Ixodes scapularis
Black-legged tick
Isca\ISCW003068
Ixodes scapularis
Black-legged tick
Isca\ISCW010886
Ixodes scapularis
Black-legged tick
Isca\ISCW010647
Ixodes scapularis
Black-legged tick
Isca\ISCW015227
Ixodes scapularis
Black-legged tick
Isca\ISCW002253
Ixodes scapularis
Black-legged tick
Isca\ISCW015235
Ixodes scapularis
Black-legged tick
Isca\ISCW015233
Ixodes scapularis
Black-legged tick
Isca\ISCW015236
Stegodyphus mimosarum
African social velvet spider
Smim\KFM74785.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM82890.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM65625.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM82810.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM79053.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM79273.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM79270.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM70965.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM73200.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM79268.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g06470
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g04190
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g09500
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g08130
Tetranychus urticae
Two-spotted spider mite
Turt\tetur09g01270
Tetranychus urticae
Two-spotted spider mite
Turt\tetur11g03780
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g09190
Tetranychus urticae
Two-spotted spider mite
Turt\tetur34g00930
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g03200
Tetranychus urticae
Two-spotted spider mite
Turt\tetur28g00900
Tetranychus urticae
Two-spotted spider mite
Turt\tetur15g02930
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g04230
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_324296
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_307269
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_324294
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_48753
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_307239
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_307240
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_322487
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_108808
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_307270
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_214082
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_41788
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_41014
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_307241
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_128564
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0N2V )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hsd17b8
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_024642gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Sdr_3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Elovl7
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Elovl4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Elovl4_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Dhrs7
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Elovl7L
Ciona intestinalis
Vase tunicate
Cint\elo
Ciona intestinalis
Vase tunicate
Cint\LOC100181604
Ciona intestinalis
Vase tunicate
Cint\LOC100184237
Ciona intestinalis
Vase tunicate
Cint\LOC100184861
Ciona intestinalis
Vase tunicate
Cint\LOC100176701
Ciona intestinalis
Vase tunicate
Cint\LOC100177165
Ciona intestinalis
Vase tunicate
Cint\LOC100180120
Ciona intestinalis
Vase tunicate
Cint\LOC100182495
Gallus gallus
Domestic chicken
Ggal\ELOVL7
Gallus gallus
Domestic chicken
Ggal\DHRS7
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000009714
Gallus gallus
Domestic chicken
Ggal\ELOVL2
Gallus gallus
Domestic chicken
Ggal\ELOVL4
Gallus gallus
Domestic chicken
Ggal\ELOVL5
Gallus gallus
Domestic chicken
Ggal\ELOVL1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (21)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG9459
7 of 10
CG17821
7 of 10
CG31141
7 of 10
CG5326
6 of 10
CG6660
6 of 10
CG8534
6 of 10
CG9458
6 of 10
CG16904
6 of 10
CG18609
6 of 10
CG30008
6 of 10
CG31522
6 of 10
CG33110
6 of 10
Elo68α
6 of 10
Elo68β
6 of 10
eloF
6 of 10
Elovl7
6 of 10
sit
6 of 10
Baldspot
5 of 10
CG31523
5 of 10
CG32071
1 of 10
tea
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ELOVL1; ELOVL fatty acid elongase 1
    5 of 15
    611813
       
      ELOVL7; ELOVL fatty acid elongase 7
      5 of 15
      614451
          ELOVL2; ELOVL fatty acid elongase 2
          3 of 15
          611814
              ELOVL3; ELOVL fatty acid elongase 3
              3 of 15
              611815
                  ELOVL4; ELOVL fatty acid elongase 4
                  3 of 15
                  605512
                  ELOVL5; ELOVL fatty acid elongase 5
                  3 of 15
                  611805
                  Functional Complementation Data
                  Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                  Interactions
                  Summary of Physical Interactions
                  esyN Network Diagram
                  Interactions Browser
                  Summary of Genetic Interactions
                  esyN Network Diagram
                  esyN Network Key:
                  Suppression
                  Enhancement
                  View in Interactions Browser
                  Please look at the allele data for full details of the genetic interactions
                  Starting gene(s)
                  Interaction type
                  Interacting gene(s)
                  Reference
                  bond
                  suppressible
                  Pex2
                  (Chen et al., 2010)
                  bond|Pex10
                  suppressible
                  Pex2
                  (Chen et al., 2010)
                  bond
                  suppressible
                  Pex10
                  (Chen et al., 2010)
                  bond|Pex2
                  suppressible
                  Pex10
                  (Chen et al., 2010)
                  Starting gene(s)
                  Interaction type
                  Interacting gene(s)
                  Reference
                  External Data
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  DroID - A comprehensive database of gene and protein interactions.
                  InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                  Pathways
                  Signaling Pathways (FlyBase)
                  Metabolic Pathways
                  External Data
                  Linkouts
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  Genomic Location and Detailed Mapping Data
                  Chromosome (arm)
                  3R
                  Recombination map

                  3-75

                  Cytogenetic map
                  94B4-94B4
                  Sequence location
                  3R:22,550,680..22,556,494 [+]
                  FlyBase Computed Cytological Location
                  Cytogenetic map
                  Evidence for location
                  94B4-94B4
                  Limits computationally determined from genome sequence between P{PZ}l(3)rQ178rQ178 and P{lacW}Dph5L4910
                  Experimentally Determined Cytological Location
                  Cytogenetic map
                  Notes
                  References
                  93F11-94D13
                  (Giansanti et al., 2004)
                  Location based on deficiency mapping.
                  (Giansanti et al., 2004)
                  Experimentally Determined Recombination Data
                  Location

                  3-75

                  (FlyBase, 2016)

                  3-77.6

                  (Comeron et al., 2012)

                  3-75.5

                  (Giansanti et al., 2004)
                  Left of (cM)
                  Right of (cM)
                  Notes
                  Stocks and Reagents
                  Stocks (7)
                  Genomic Clones (26)
                  cDNA Clones (30)
                   

                  Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                  cDNA clones, fully sequenced
                  BDGP DGC clones
                  Other clones
                  Drosophila Genomics Resource Center cDNA clones

                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                  Other clones
                  RNAi and Array Information
                  Linkouts
                  DRSC - Results frm RNAi screens
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  Antibody Information
                  Laboratory Generated Antibodies
                   

                  polyclonal

                  (Ng et al., 2015)
                  Commercially Available Antibodies
                   
                  Other Information
                  Relationship to Other Genes
                  Source for database identify of
                  Source for database merge of

                  Source for merge of: bond CG6921

                  (Szafer-Glusman et al., 2008)
                  Additional comments
                  Other Comments
                  Origin and Etymology
                  Discoverer
                  Etymology
                  Identification
                  External Crossreferences and Linkouts ( 42 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  Flygut - An atlas of the Drosophila adult midgut
                  FlyMine - An integrated database for Drosophila genomics
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  modMine - A data warehouse for the modENCODE project
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                  InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  Synonyms and Secondary IDs (4)
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  References (50)