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Gene Dmel\Atg1

General Information
Symbol	Dmel\Atg1	Species	D. melanogaster
Name	Autophagy-specific gene 1	Annotation symbol	CG10967
Feature type	protein_coding_gene	FlyBase ID	FBgn0260945
Gene Model Status	Current	Stock availability	21 publicly available
Also Known As	l(3)00305, unc-51, DK-4
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	69E2-69E4	Sequence location	3L:12,777,529..12,798,214 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Autophagy-specific gene 1 is referred to in FlyBase by the symbol Dmel\Atg1 (CG10967, FBgn0260945). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: kinesin binding; protein kinase activity. There is experimental evidence that it is involved in the biological process: regulation of synaptic transmission; regulation of cell growth; nurse cell apoptosis; larval midgut histolysis; synaptic growth at neuromuscular junction; negative regulation of TOR signaling cascade; regulation of autophagy; autophagy; axon cargo transport; synapse organization. 45 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; multicellular structure; portion of tissue; anatomical structure; adult; embryonic/larval hemocoel; cytoplasmic part; embryonic/larval fat body; synapse; external compound sense organ. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase Unc-51; Serine/threonine-protein kinase, C-terminal; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase, catalytic domain; Serine/threonine-protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system, adult fat body. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1627886_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Atg1. Gene sequence location is 3L:12777529..12798214.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Controlled Vocabulary Terms blastoderm stage organism embryonic stage 8 gastrula stage embryonic/larval central nervous system dorsal closure stage embryonic stage 9 embryonic stage 6 early extended germ band stage extended germ band stage embryonic stage 4 embryonic cycle 9 embryonic stage 2 ventral nerve cord late extended germ band stage embryonic stage 5 third instar larval stage embryonic stage 12 embryonic stage 11 presumptive embryonic/larval central nervous system embryonic stage 3 embryonic stage 15 embryonic stage 13 embryonic stage 14 embryonic stage 10 restricted embryonic stage 16 embryonic stage 7 Unknown in situ
FB2012_01	Sequence features HFA09809 BKN50158 HFA09810 BKN50167 BKN27684
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 69E2-69E4   Limits computationally determined from genome sequence between P{PZ}l(3)0508805088 and P{PZ}l(3)0692406924
Experimentally Determined Cytological Location
Cytogenetic map Notes References 69E3-69E5   (determined by in situ hybridisation)   (Spradling et al., 1999) 69E3-69E5     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Atg1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Atg1-RA FBtr0075945  NM_140344   4086   835 Atg1-RB FBtr0300561  NM_001169962   3415   855
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Atg1-PA   FBpp0075677   90.6   835   8.33     NP_648601   AAF49878 Atg1-PB   FBpp0289788   92.8   855   8.58     NP_001163433   ACZ94704
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Serine/threonine-protein kinase Unc-51 (IPR017184) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442) Serine/threonine-protein kinase, C-terminal (IPR022708)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA441187   AA539224   AA694862   AE014296 AAF49878   AE014296 ACZ94704   AI062265   AI064128   AI107039   AI109191   AI109338   AI113939   AI259702   AI386727   AI405057   AI531335   AI532915   AI533816   AI533983   AQ025204   AQ025215   AQ073934   AQ254741   AW942504   AX094163   AX094254   AY129445 AAM76187   BE978245   BF487638   BF487639   BF493693   BF495233   BG633547   BG633550   BG637195   BG639303   BH614852   BI165678   BI165765   BI171589   BI173550   BI213305   BI215481   BI239787   BI241543   BI243643   BI376007   BI482326   BI482358   BI482386   BI482907   BI484707   BI615845   BI619057   BI639687   BP559426   BP559427   BT021340 AAX33488   BZ286274   CL528008   CL705841   CO177606   CO189331   CO195186   CO269684   CO295641   CO306244   CO312909   CO315835   CO337100   CO341346   CZ467034   CZ467035   CZ468715   CZ469112   CZ472799   CZ476515   CZ477318   CZ479589   CZ490807   CZ490808   EC052546   EC052549   EC052550   EC052554   EC052988   EC053558   EC055348   EC055419   EC055595   EC056204   EC071317   EC076492   EC079368   EC086972   EC198597   EC200681   EC226211   EC238410   EC241200   EC252172   EC261513   EL883078   EL883190   EV575884   G00463   GH739863   GH741355   GH743057   GH744508   GH746381   GH763821   GH764901   GO254386   GO254478
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8MQJ7 Q9VU14
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 2 -- 16   organism | restricted   (Toda et al., 2008) embryonic stage 10 -- 15   presumptive embryonic/larval central nervous system   (Toda et al., 2008) embryonic stage 16   embryonic/larval central nervous system   (Toda et al., 2008)
Additional Descriptive Data
	Atg1 transcripts are widely distributed in stage 2 embryos and continue to be expressed throughout embryogenesis. They become increasingly concentrated in the nervous system. (Toda et al., 2008)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   ventral nerve cord   (Toda et al., 2008) Comment:axonal bundles
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0260945    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0260945 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0260945 expression level Developmental Stage   Expression Level embryo 00-02hr    3689 embryo 02-04hr    2689 embryo 04-06hr    1528 embryo 06-08hr    1665 embryo 08-10hr    1588 embryo 10-12hr    1548 embryo 12-14hr    1510 embryo 14-16hr    1803 embryo 16-18hr    1900 embryo 18-20hr    1969 embryo 20-22hr    2960 embryo 22-24hr    2721 larva L1    1069 larva L2    599 larva L3 12hr old    605 larva L3 puffstage 1-2    517 larva L3 puffstage 3-6    1412 larva L3 puffstage 7-9    2058 white prepupae new    1734 white prepupae 12hr    2372 white prepupae 24hr    1674 pupae 2d postWPP    1815 pupae 3d postWPP    886 pupae 4d postWPP    1961 adult male 01day    1070 adult male 05day    1046 adult male 30day    901 adult female 01day    1744 adult female 05day    2466 adult female 30day    2615 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3689) embryo 02-04hr  (2689) embryo 04-06hr  (1528) embryo 06-08hr  (1665) embryo 08-10hr  (1588) embryo 10-12hr  (1548) embryo 12-14hr  (1510) embryo 14-16hr  (1803) embryo 16-18hr  (1900) embryo 18-20hr  (1969) embryo 20-22hr  (2960) embryo 22-24hr  (2721) larva L1  (1069) larva L2  (599) larva L3 12hr old  (605) larva L3 puffstage 1-2  (517) larva L3 puffstage 3-6  (1412) larva L3 puffstage 7-9  (2058) white prepupae new  (1734) white prepupae 12hr  (2372) white prepupae 24hr  (1674) pupae 2d postWPP  (1815) pupae 3d postWPP  (886) pupae 4d postWPP  (1961) adult male 01day  (1070) adult male 05day  (1046) adult male 30day  (901) adult female 01day  (1744) adult female 05day  (2466) adult female 30day  (2615) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3689) embryo 02-04hr  (2689) embryo 04-06hr  (1528) embryo 06-08hr  (1665) embryo 08-10hr  (1588) embryo 10-12hr  (1548) embryo 12-14hr  (1510) embryo 14-16hr  (1803) embryo 16-18hr  (1900) embryo 18-20hr  (1969) embryo 20-22hr  (2960) embryo 22-24hr  (2721) larva L1    1069 larva L2    599 larva L3 12hr old    605 larva L3 puffstage 1-2    517 larva L3 puffstage 3-6  1412 larva L3 puffstage 7-9  (2058) white prepupae new  (1734) white prepupae 12hr  (2372) white prepupae 24hr  (1674) pupae 2d postWPP  (1815) pupae 3d postWPP    886 pupae 4d postWPP  (1961) adult male 01day    1070 adult male 05day    1046 adult male 30day    901 adult female 01day  (1744) adult female 05day  (2466) adult female 30day  (2615) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3689 embryo 02-04hr    2689 embryo 04-06hr    1528 embryo 06-08hr    1665 embryo 08-10hr    1588 embryo 10-12hr    1548 embryo 12-14hr    1510 embryo 14-16hr    1803 embryo 16-18hr    1900 embryo 18-20hr    1969 embryo 20-22hr    2960 embryo 22-24hr    2721 larva L1    1069 larva L2    599 larva L3 12hr old    605 larva L3 puffstage 1-2    517 larva L3 puffstage 3-6    1412 larva L3 puffstage 7-9    2058 white prepupae new    1734 white prepupae 12hr    2372 white prepupae 24hr    1674 pupae 2d postWPP    1815 pupae 3d postWPP    886 pupae 4d postWPP    1961 adult male 01day    1070 adult male 05day    1046 adult male 30day    901 adult female 01day    1744 adult female 05day    2466 adult female 30day    2615 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3689 embryo 02-04hr    2689 embryo 04-06hr    1528 embryo 06-08hr    1665 embryo 08-10hr    1588 embryo 10-12hr    1548 embryo 12-14hr    1510 embryo 14-16hr    1803 embryo 16-18hr    1900 embryo 18-20hr    1969 embryo 20-22hr    2960 embryo 22-24hr    2721 larva L1    1069 larva L2    599 larva L3 12hr old    605 larva L3 puffstage 1-2    517 larva L3 puffstage 3-6    1412 larva L3 puffstage 7-9    2058 white prepupae new    1734 white prepupae 12hr    2372 white prepupae 24hr    1674 pupae 2d postWPP    1815 pupae 3d postWPP    886 pupae 4d postWPP    1961 adult male 01day    1070 adult male 05day    1046 adult male 30day    901 adult female 01day    1744 adult female 05day    2466 adult female 30day    2615 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0260945 expression level Developmental Stage   Expression Level embryo 00-02hr    3689 embryo 02-04hr    2689 embryo 04-06hr    1528 embryo 06-08hr    1665 embryo 08-10hr    1588 embryo 10-12hr    1548 embryo 12-14hr    1510 embryo 14-16hr    1803 embryo 16-18hr    1900 embryo 18-20hr    1969 embryo 20-22hr    2960 embryo 22-24hr    2721 larva L1    1069 larva L2    599 larva L3 12hr old    605 larva L3 puffstage 1-2    517 larva L3 puffstage 3-6    1412 larva L3 puffstage 7-9    2058 white prepupae new    1734 white prepupae 12hr    2372 white prepupae 24hr    1674 pupae 2d postWPP    1815 pupae 3d postWPP    886 pupae 4d postWPP    1961 adult male 01day    1070 adult male 05day    1046 adult male 30day    901 adult female 01day    1744 adult female 05day    2466 adult female 30day    2615 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3689) embryo 02-04hr  (2689) embryo 04-06hr  (1528) embryo 06-08hr  (1665) embryo 08-10hr  (1588) embryo 10-12hr  (1548) embryo 12-14hr  (1510) embryo 14-16hr  (1803) embryo 16-18hr  (1900) embryo 18-20hr  (1969) embryo 20-22hr  (2960) embryo 22-24hr  (2721) larva L1  (1069) larva L2  (599) larva L3 12hr old  (605) larva L3 puffstage 1-2  (517) larva L3 puffstage 3-6  (1412) larva L3 puffstage 7-9  (2058) white prepupae new  (1734) white prepupae 12hr  (2372) white prepupae 24hr  (1674) pupae 2d postWPP  (1815) pupae 3d postWPP  (886) pupae 4d postWPP  (1961) adult male 01day  (1070) adult male 05day  (1046) adult male 30day  (901) adult female 01day  (1744) adult female 05day  (2466) adult female 30day  (2615) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3689) embryo 02-04hr  (2689) embryo 04-06hr  1528 embryo 06-08hr  1665 embryo 08-10hr  1588 embryo 10-12hr  1548 embryo 12-14hr  1510 embryo 14-16hr  1803 embryo 16-18hr  1900 embryo 18-20hr  1969 embryo 20-22hr  (2960) embryo 22-24hr  (2721) larva L1    1069 larva L2    599 larva L3 12hr old    605 larva L3 puffstage 1-2    517 larva L3 puffstage 3-6  1412 larva L3 puffstage 7-9  2058 white prepupae new  1734 white prepupae 12hr  2372 white prepupae 24hr  1674 pupae 2d postWPP  1815 pupae 3d postWPP    886 pupae 4d postWPP  1961 adult male 01day    1070 adult male 05day    1046 adult male 30day    901 adult female 01day  1744 adult female 05day  2466 adult female 30day  (2615) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3689 embryo 02-04hr    2689 embryo 04-06hr    1528 embryo 06-08hr    1665 embryo 08-10hr    1588 embryo 10-12hr    1548 embryo 12-14hr    1510 embryo 14-16hr    1803 embryo 16-18hr    1900 embryo 18-20hr    1969 embryo 20-22hr    2960 embryo 22-24hr    2721 larva L1    1069 larva L2    599 larva L3 12hr old    605 larva L3 puffstage 1-2    517 larva L3 puffstage 3-6    1412 larva L3 puffstage 7-9    2058 white prepupae new    1734 white prepupae 12hr    2372 white prepupae 24hr    1674 pupae 2d postWPP    1815 pupae 3d postWPP    886 pupae 4d postWPP    1961 adult male 01day    1070 adult male 05day    1046 adult male 30day    901 adult female 01day    1744 adult female 05day    2466 adult female 30day    2615 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3689 embryo 02-04hr    2689 embryo 04-06hr    1528 embryo 06-08hr    1665 embryo 08-10hr    1588 embryo 10-12hr    1548 embryo 12-14hr    1510 embryo 14-16hr    1803 embryo 16-18hr    1900 embryo 18-20hr    1969 embryo 20-22hr    2960 embryo 22-24hr    2721 larva L1    1069 larva L2    599 larva L3 12hr old    605 larva L3 puffstage 1-2    517 larva L3 puffstage 3-6    1412 larva L3 puffstage 7-9    2058 white prepupae new    1734 white prepupae 12hr    2372 white prepupae 24hr    1674 pupae 2d postWPP    1815 pupae 3d postWPP    886 pupae 4d postWPP    1961 adult male 01day    1070 adult male 05day    1046 adult male 30day    901 adult female 01day    1744 adult female 05day    2466 adult female 30day    2615 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0260945    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0260945 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system, adult fat body. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0260945 expression level Tissue   Expression Level Larval Central Nervous System    380.5 Larval Midgut    203 Larval Hindgut    177.3 Larval Malpighian Tubules    444 Larval Fat Body    443.3 Larval Salivary Gland    221.8 Larval Trachea    161.525 Larval Carcass    188.575 Adult Head    340.5 Adult Eye    367.7 Adult Brain    770.7 Adult Thoracic-Abdominal Ganglion    751.3 Adult Crop    308.4 Adult Midgut    247.2 Adult Hindgut    202.6 Adult Malpighian Tubules    274.5 Adult Fat Body    531.5 Adult Salivary Gland    369.3 Adult Heart    282.025 Adult VirginFemale Spermatheca    335.1 Adult InseminatedFemale Spermatheca    303.6 Adult Ovary    326.7 Adult Testis    58.5 Adult Male Accessory Gland    104.3 Adult Carcass    316.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    380.5 Larval Midgut    203 Larval Hindgut    177.3 Larval Malpighian Tubules    444 Larval Fat Body    443.3 Larval Salivary Gland    221.8 Larval Trachea    161.525 Larval Carcass    188.575 Adult Head    340.5 Adult Eye    367.7 Adult Brain  (770.7) Adult Thoracic-Abdominal Ganglion  (751.3) Adult Crop    308.4 Adult Midgut    247.2 Adult Hindgut    202.6 Adult Malpighian Tubules    274.5 Adult Fat Body  531.5 Adult Salivary Gland    369.3 Adult Heart    282.025 Adult VirginFemale Spermatheca    335.1 Adult InseminatedFemale Spermatheca    303.6 Adult Ovary    326.7 Adult Testis    58.5 Adult Male Accessory Gland    104.3 Adult Carcass    316.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    380.5 Larval Midgut    203 Larval Hindgut    177.3 Larval Malpighian Tubules    444 Larval Fat Body    443.3 Larval Salivary Gland    221.8 Larval Trachea    161.525 Larval Carcass    188.575 Adult Head    340.5 Adult Eye    367.7 Adult Brain    770.7 Adult Thoracic-Abdominal Ganglion    751.3 Adult Crop    308.4 Adult Midgut    247.2 Adult Hindgut    202.6 Adult Malpighian Tubules    274.5 Adult Fat Body    531.5 Adult Salivary Gland    369.3 Adult Heart    282.025 Adult VirginFemale Spermatheca    335.1 Adult InseminatedFemale Spermatheca    303.6 Adult Ovary    326.7 Adult Testis    58.5 Adult Male Accessory Gland    104.3 Adult Carcass    316.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    380.5 Larval Midgut    203 Larval Hindgut    177.3 Larval Malpighian Tubules    444 Larval Fat Body    443.3 Larval Salivary Gland    221.8 Larval Trachea    161.525 Larval Carcass    188.575 Adult Head    340.5 Adult Eye    367.7 Adult Brain    770.7 Adult Thoracic-Abdominal Ganglion    751.3 Adult Crop    308.4 Adult Midgut    247.2 Adult Hindgut    202.6 Adult Malpighian Tubules    274.5 Adult Fat Body    531.5 Adult Salivary Gland    369.3 Adult Heart    282.025 Adult VirginFemale Spermatheca    335.1 Adult InseminatedFemale Spermatheca    303.6 Adult Ovary    326.7 Adult Testis    58.5 Adult Male Accessory Gland    104.3 Adult Carcass    316.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0260945 expression level Tissue   Expression Level Larval Central Nervous System    380.5 Larval Midgut    203 Larval Hindgut    177.3 Larval Malpighian Tubules    444 Larval Fat Body    443.3 Larval Salivary Gland    221.8 Larval Trachea    161.525 Larval Carcass    188.575 Adult Head    340.5 Adult Eye    367.7 Adult Brain    770.7 Adult Thoracic-Abdominal Ganglion    751.3 Adult Crop    308.4 Adult Midgut    247.2 Adult Hindgut    202.6 Adult Malpighian Tubules    274.5 Adult Fat Body    531.5 Adult Salivary Gland    369.3 Adult Heart    282.025 Adult VirginFemale Spermatheca    335.1 Adult InseminatedFemale Spermatheca    303.6 Adult Ovary    326.7 Adult Testis    58.5 Adult Male Accessory Gland    104.3 Adult Carcass    316.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    380.5 Larval Midgut    203 Larval Hindgut    177.3 Larval Malpighian Tubules    444 Larval Fat Body    443.3 Larval Salivary Gland    221.8 Larval Trachea    161.525 Larval Carcass    188.575 Adult Head    340.5 Adult Eye    367.7 Adult Brain  770.7 Adult Thoracic-Abdominal Ganglion  751.3 Adult Crop    308.4 Adult Midgut    247.2 Adult Hindgut    202.6 Adult Malpighian Tubules    274.5 Adult Fat Body  531.5 Adult Salivary Gland    369.3 Adult Heart    282.025 Adult VirginFemale Spermatheca    335.1 Adult InseminatedFemale Spermatheca    303.6 Adult Ovary    326.7 Adult Testis    58.5 Adult Male Accessory Gland    104.3 Adult Carcass    316.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    380.5 Larval Midgut    203 Larval Hindgut    177.3 Larval Malpighian Tubules    444 Larval Fat Body    443.3 Larval Salivary Gland    221.8 Larval Trachea    161.525 Larval Carcass    188.575 Adult Head    340.5 Adult Eye    367.7 Adult Brain    770.7 Adult Thoracic-Abdominal Ganglion    751.3 Adult Crop    308.4 Adult Midgut    247.2 Adult Hindgut    202.6 Adult Malpighian Tubules    274.5 Adult Fat Body    531.5 Adult Salivary Gland    369.3 Adult Heart    282.025 Adult VirginFemale Spermatheca    335.1 Adult InseminatedFemale Spermatheca    303.6 Adult Ovary    326.7 Adult Testis    58.5 Adult Male Accessory Gland    104.3 Adult Carcass    316.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    380.5 Larval Midgut    203 Larval Hindgut    177.3 Larval Malpighian Tubules    444 Larval Fat Body    443.3 Larval Salivary Gland    221.8 Larval Trachea    161.525 Larval Carcass    188.575 Adult Head    340.5 Adult Eye    367.7 Adult Brain    770.7 Adult Thoracic-Abdominal Ganglion    751.3 Adult Crop    308.4 Adult Midgut    247.2 Adult Hindgut    202.6 Adult Malpighian Tubules    274.5 Adult Fat Body    531.5 Adult Salivary Gland    369.3 Adult Heart    282.025 Adult VirginFemale Spermatheca    335.1 Adult InseminatedFemale Spermatheca    303.6 Adult Ovary    326.7 Adult Testis    58.5 Adult Male Accessory Gland    104.3 Adult Carcass    316.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    340.5   NA  Eye    367.7   NA  Brain    770.7   380.5  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    751.3   NA  Crop    308.4   203  Midgut    247.2   177.3  Hindgut    202.6   444  Malpighian Tubules    274.5   443.3  Fat Body    531.5   221.8  Salivary Gland    369.3   NA  Heart    282.025   161.525  Trachea    NA   NA  VirginFemale Spermatheca    335.1   NA  InseminatedFemale Spermatheca    303.6   NA  Ovary    326.7   NA  Testis    58.5   NA  Male Accessory Gland    104.3   188.575  Carcass    316.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_27
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0260945
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | germline clone | larval stage Atg1Δ3D lethal | partially, with Scer\GAL4GMR.PF Atg1Scer\UAS.cSa lethal | pupal stage Atg13 Atg125 Atg1Δ3D lethal | pupal stage (with Atg13) Atg125 lethal | pupal stage (with Atg125) Atg13 lethal | pupal stage (with Df(3L)ED4486) Atg13 Atg125 lethal | pupal stage | recessive Atg1Δ3D lethal | pupal stage | recessive, with Scer\GAL4[-]: Atg1EP3009 Atg1EP3348 lethal | recessive Atg100305 Atg101413 semi-lethal Atg1EP3348 semi-lethal | adult stage Atg1EP3348 viable Atg1EP3193 viable, with Scer\GAL4pnr-MD237 Atg1GD7149 Other Phenotypes Allele cell death defective | germline clone Atg1Δ3D cell death defective | germline clone | oogenesis stage S14 Atg1Δ3D cell death defective | somatic clone Atg1Δ3D decreased cell death | somatic clone Atg1Δ3D decreased cell size, with Scer\GAL4Cg.PA Atg1GS10797 decreased cell size | somatic clone, with Scer\GAL4Act5C.PP Atg1Scer\UAS.cSa developmental rate defective | germline clone Atg1Δ3D increased cell death, with Scer\GAL4Cg.PA Atg1GS10797 Atg1Scer\UAS.cSa increased cell death | somatic clone, with Scer\GAL4Act5C.PP Atg1Scer\UAS.cSa increased cell growth, with Scer\GAL4elav.PLu Atg1Scer\UAS.cSa locomotor behavior defective | larval stage Atg1unspecified neuroanatomy defective, with Scer\GAL4elav.PLu Atg1Scer\UAS.cSa neuroanatomy defective | dominant | embryonic stage Atg1EP3348 neuroanatomy defective | embryonic stage Atg1unspecified neurophysiology defective (with Atg13) Atg1EY07351 neurophysiology defective (with Atg1EY07351) Atg13 neurophysiology defective | recessive Atg13 Atg1Scer\UAS.cWa visible, with Scer\GAL4GMR.PF Atg1Scer\UAS.cSa Phenotype manifest in Allele adult heart, with Scer\GAL4HCH.Hand Atg1JF02273 autophagic vacuole | conditional Atg1EP3348 axon & motor neuron | larval stage Atg13 commissure Atg1EP3348 dorsal appendage | somatic clone Atg1Δ3D egg | somatic clone Atg1Δ3D egg chamber | germline clone | oogenesis stage S14 Atg1Δ3D egg chamber | somatic clone Atg1Δ3D embryonic/larval cuticle | somatic clone Atg1Δ3D embryonic/larval fat body, with Scer\GAL4Cg.PA Atg1GS10797 embryonic/larval hemocyte Atg1Δ3D embryonic/larval midgut | P-stage, with Scer\GAL4NP1 Atg1GD7149 embryonic/larval salivary gland, with Scer\GAL4fkh.PH Atg1K38Q.Scer\UAS Atg1GS10797 eye, with Scer\GAL4GMR.PF Atg1Scer\UAS.cSa fat body Atg1Δ3D fat body, with Scer\GAL4Cg.PA Atg1GS10797 fat body, with Scer\GAL4hs.PH Atg1Scer\UAS.cSa fat body | somatic clone, with Scer\GAL4Act5C.PP Atg1Scer\UAS.cSa germarium | somatic clone Atg1Δ3D longitudinal connective Atg1EP3348 Atg1unspecified mitochondrion, with Scer\GAL4Mef2.PR Atg1JF02273 neuromuscular junction Atg1EY09216 Atg125 neuromuscular junction, with Scer\GAL4elav.PLu Atg1Scer\UAS.cSa neuromuscular junction (with Atg13) Atg125 neuromuscular junction (with Atg125) Atg13 neuromuscular junction | larval stage Atg13 neuromuscular junction | larval stage (with Atg13) Atg125 neuromuscular junction | larval stage (with Atg125) Atg13 NMJ bouton, with Scer\GAL4elav.PLu Atg1Scer\UAS.cSa nurse cell | germline clone | oogenesis stage S14 Atg1Δ3D presynaptic active zone & neuromuscular junction | larval stage Atg13 t-bar & neuromuscular junction | larval stage Atg13 ventral nerve cord Atg1unspecified
Classical Alleles ( 33 )
For All Classical Alleles Show
Allele of Atg1 Class Mutagen Stocks Known lesion Atg1KG07993 P-element activity 2 -- Atg100305 P-element activity 1 -- Atg1c01274 piggyBac transposase 1 -- Atg1c03554 piggyBac transposase 1 -- Atg1c04248 piggyBac transposase 1 -- Atg1CB-6698-3 1 -- Atg1d01142 1 -- Atg1d08049 1 -- Atg1DG23110 P-element activity 1 -- Atg1e01773 piggyBac transposase 1 -- Atg1EY07351 P-element activity 1 -- Atg1EY09216 P-element activity 1 -- Atg1f06013 1 -- Atg1f08109 piggyBac transposase 1 -- Atg1KG01077 P-element activity 1 -- Atg1NP1606 1 -- Atg1NP5328 1 -- Atg101413 P-element activity 0 -- Atg125 loss of function allele Delta2-3 P-element activity 0 Yes Atg13 loss of function allele Delta2-3 P-element activity 0 Yes Atg1c02842 0 -- Atg1d02414 P-element activity 0 -- Atg1d06130 0 -- Atg1d09008 P-element activity 0 -- Atg1d10548 P-element activity 0 -- Atg1EP1246 P-element activity 0 -- Atg1EP3009 P-element activity 0 -- Atg1EP3193 P-element activity 0 Yes Atg1EP3348 P-element activity 0 Yes Atg1EP3622 P-element activity 0 -- Atg1GS10797 0 -- Atg1unspecified 0 -- Atg1Δ3D loss of function allele P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Atg1 Class Mutagen Stocks Known lesion Atg1GD7149 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Atg1GL00047 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Atg1JF02273 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Atg1K38A.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes Atg1K38Q.Scer\UAS.T:Hsap\MYC in vitro construct - coding region fusion 0 Yes Atg1K38Q.Scer\UAS in vitro construct - regulatory fusion 0 Yes Atg1Scer\UAS.cSa in vitro construct - regulatory fusion 0 Yes Atg1Scer\UAS.cTa in vitro construct - regulatory fusion 0 Yes Atg1Scer\UAS.cUa in vitro construct - regulatory fusion 0 Yes Atg1Scer\UAS.cWa in vitro construct - regulatory fusion 0 Yes Atg1Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Atg1W.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)BSC613 (Christensen et al., 2008.9.29) Df(3L)BSC730 (Christensen et al., 2009.2.28)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7149} NA P{TRiP.GL00047} NA P{TRiP.JF02273} NA P{UAS-Atg1.K38Q} NA P{UAS-Atg1.Myc} NA P{UAS-Atg1.S} NA P{UAS-Atg1.U} NA P{UAS-Atg1.W} NA P{UAS-Myc-Atg1.KD} NA P{UAS-Myc-Atg1} NA P{UAS-unc-51.K38A} NA P{UAS-unc-51.WT} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Atg1EP1246 NA P{EP}Atg1EP3009 NA P{EP}Atg1EP3348 NA P{EP}CG42709EP3193 NA P{EP}CG42709EP3622 NA P{EPgy2}Atg1EY07351 NA P{EPgy2}Atg1EY09216 NA P{GSV6}Atg1GS10797 NA P{Mae-UAS.6.11}B0432B0432 NA P{Mae-UAS.6.11}B2035B2035 NA P{XP}Atg1d01142 NA P{XP}Atg1d02414 NA P{XP}Atg1d06130 NA P{XP}Atg1d08049 NA P{XP}Atg1d09008 NA P{XP}Atg1d10548 NA insertion of enhancer trap P{PZ}Atg100305 No P{PZ}Atg101413 No miscellaneous insertions P{RS3}Atg1CB-6698-3 NA P{SUPor-P}Atg1KG01077 NA P{SUPor-P}Atg1KG07993 NA P{wHy}Atg1DG23110 NA PBac{PB}Atg1c01274 NA PBac{PB}Atg1c02842 NA PBac{PB}Atg1c03554 NA PBac{PB}Atg1c04248 NA PBac{RB}Atg1e01773 NA PBac{WH}Atg1f06013 NA PBac{WH}Atg1f08109 NA insertion of enhancer trap binary system P{GawB}Atg1NP1606 No P{GawB}Atg1NP5328 No
Gene Ontology: Function, Process & Cellular Component ( 16 unique terms )
Terms Based on Experimental Evidence ( 12 terms )
Molecular Function
CV term Evidence References
kinesin binding inferred from mutant phenotype (Mochizuki et al., 2006) protein kinase activity inferred from direct assay (Toda et al., 2008)
Biological Process
CV term Evidence References
autophagy inferred from mutant phenotype (Scott et al., 2004, Scott et al., 2004, Scott et al., 2007) axon cargo transport inferred from mutant phenotype (Wairkar et al., 2009, Toda et al., 2008) larval midgut histolysis inferred from mutant phenotype (Denton et al., 2009) negative regulation of TOR signaling cascade inferred from mutant phenotype (Lee et al., 2007) nurse cell apoptosis inferred from mutant phenotype (Bass et al., 2009) regulation of autophagy inferred from mutant phenotype (Barth et al., 2011) regulation of cell growth inferred from mutant phenotype (Lee et al., 2007) regulation of synaptic transmission inferred from mutant phenotype (Wairkar et al., 2009) synapse organization inferred from mutant phenotype (Wairkar et al., 2009) synaptic growth at neuromuscular junction inferred from mutant phenotype (Wairkar et al., 2009)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441 (FlyBase Curators et al., 2004-) kinase activity non-traceable author statement (Ahantarig et al., 2003) protein kinase activity inferred from sequence or structural similarity with worm unc-51 (Ahantarig et al., 2001) non-traceable author statement (Morrison et al., 2000) protein serine/threonine kinase activity inferred from sequence or structural similarity with UniProtKB:Q23023 (FlyBase, 1992-)
Biological Process
CV term Evidence References
protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR008271 (FlyBase Curators et al., 2004-) non-traceable author statement (Morrison et al., 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Atg1 allele Gene References Atg1Δ3D Tor (Scott et al., 2004) unspecified Atg12 (Berry and Baehrecke, 2007) bchs (Simonsen et al., 2007)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64801 DroID - A comprehensive database of gene and protein interactions. • FBgn0260945 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39454
Orthologs
Genome-wide drosophilid orthologs	Dana\GF10866 Dere\GG13803 Dgri\GH14495 Dmoj\GI13651 Dper\GL22897 Dpse\GA10675 Dsec\GM24629 Dsim\GD12696 Dvir\GJ13984 Dwil\GK17359 Dyak\GE20096
Curated drosophilid orthologs	Dlit\CG10967   Dpse\GA10675
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL003819-PA Aedes aegypti (mosquito) AGAP011295-PA Anopheles gambiae (mosquito) XP_624950.1 Apis mellifera (honey bee) XP_001944514.1 Acyrthosiphon pisum (pea aphid) At2g37840.1 Arabidopsis thaliana (wall cress) BGIBMGA005492-PA Bombyx mori (silk worm) ENSBTAP00000017268 Bos taurus (bovine) CN19755 Caenorhabditis brenneri (small nematode) CBP28157 Caenorhabditis briggsae (nematode) CE24516 Caenorhabditis elegans (worm) ENSCAFP00000026786 Canis familiaris (dog) CAGL0L06006g Candida glabrata (haploid yeast) JA11795 Caenorhabditis japonica (nematode) cn09073 Cryptococcus neoformans (yeast-like fungus) CPIJ001273 Culex pipens (mosquito) ENSCPOP00000009021 Cavia porcellus (guinea pig) RP28066 Caenorhabditis remanei (nematode) 170802 Capitella spl (polychaete worm) DDB0185178 Dictyostelium discoideum (amoeba) DEHA2D12452g Debaryomyces Hansenii (yeast) 101872 Daphnia pulex (daphnia) ENSDARP00000083843 Danio rerio (zebra fish) ENSECAP00000014390 Equus caballus (horse) ENSGACP00000017889 Gymnopilus aculeatus (mushroom) ENSGALP00000007513 Gallus gallus (chicken) ENSP00000354877 Homo sapiens (human) ISCW007457-PA Ixodes scapularis (deer tick) 34023 Monocosta brevicollis (choanoflagellate) ENSMODP00000005348 Monodelphis domestica (gray opossum) ENSMMUP00000027852 Macaca mulatta (rhesus monkey) ENSMUSP00000004920 Mus musculus (house mouse) XP_001607390.1 Nasonia vitripennis (wasp) ENSORLP00000013892 Oryzias latipes (japanese killifish) PHUM002890-PA Pediculus humanus (human body louse) PP26225 Pristionchus pacificus (nematode) 201085 Physcomitrella patens (moss) ENSPPYP00000009920 Pongo pygmaeus (orangutan) 572478 Populus trichocarpa (black cottonwood) ENSPTRP00000042372 Pan troglodytes (chimpanzee) ENSRNOP00000003792 Rattus norvegicus (norway rat) YGL180W Saccharomyces cerevisiae (budding yeast) Smp_157350 Schistosoma mansoni (trematode parasite) SPCC63.08c Schizosaccharomyces pombe (fission yeast) XP_798577.2 Strongylocentrotus purpuratus (purple sea urchin) XP_970539.1 Tribolium castaneum (red flour beetle) Tc00.1047053510285.70 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000017404 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000029855 Takifugu rubripes (pufferfish Takifugu) 3692.m00138 Tetrahymena thermophila (ciliate protozoa) YALI0D25388g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11803 LH18738 ISCW007457 FBgn0237419 FBgn0219358 FBgn0201202 FBgn0184423 FBgn0184422 FBgn0179492 JGI_V11_101872 FBgn0070731 FBgn0160487 FBgn0136406 FBgn0121971 FBgn0106066 FBgn0087906 CPIJ001273 BGIBMGA005492 ACYPI000902 GB16313 AGAP011295 AAEL016987 AAEL003819 PB25017 PB25018 PHUM233660 GLEAN_05477
Stocks & Reagents
Stocks Listed in FlyBase ( 21 )
Bloomington	26731 y1 v1; P{TRiP.JF02273}attP2 35177 y1 sc* v1; P{TRiP.GL00047}attP2/TM3, Sb1
Harvard	- P{XP}Atg1d01142 - P{XP}Atg1d08049 - PBac{PB}Atg1c01274 - PBac{PB}Atg1c03554 - PBac{PB}Atg1c04248 - PBac{RB}Atg1e01773 - PBac{WH}Atg1f06013 - PBac{WH}Atg1f08109
Kyoto	124187 w1118; P{RS3}Atg1CB-6698-3
VDRC	v16133 w1118; P{GD7149}v16133
	More stocks available...
Genomic Clones ( 2 )
	BACR20B01 BACR20I01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 86 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD18893 LP23904
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT02023 AT04109 AT22630 AT22631 GH01412 GH04395 GH06326 GH08313 GH08489 GH10465 GH16911 GH24968 GM01643 LD16089 RE05619 RE05719 RE13401 RE16486 RE18678 RE21892 RE36373 RE38638 RE41348 RE63926 RE65006 RE65042 RE65072 RE65716 RE67849 RH45718 RH50022 SD02327 SD04565 SD05780 SD06376 SD15073 SD22338
Other clones	16397 63958 77779 105233 144282 159689 214321.38 281539 562161 bs75h04 CK01.54A.E1 CK01.129A.D4 Dmel_dig_010453_0708_2700 EC39837 EC052546 EC052549 EC052550 EC052554 EC052988 EC053558 EC055348 EC055419 EC055595 EC056204 EK044017 EK053908 EK095535 EK211144 EK230534 EK250613 EK262646 EN13832 EP12310 FGM320H07 GM01688 IP12806 IP12906 LP03175 RP01234 RP01355 RP001007262 RP001010919 RP001012319 RP001015230 RP001019534 RP001052076 RP001053595
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0260945 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39454
Antibody Information
	polyclonal (Toda et al., 2008, Ahantarig et al., 2009)
Other Information
Discoverer
Etymology
	The gene is named "Pegarn" which is a Thai word, meaning "unable to function normally since some part is missing". (Ahantarig et al., 2009)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: atg1 l(3)00305 (Scott, 2005.3.2)
Source for database merge of	Source for merge of: Atg1 anon-WO0118547.287 (FlyBase, 1996-) Source for merge of: Atg1 unc-51 (Wairkar et al., 2009) Source for merge of: l(3)00305 CG10967 (FlyBase, 1996-)
Additional comments	The gene corresponding to the CG17667 annotation was previously mistakenly renamed to "Pegarn" in FlyBase. "Pegarn" does not correspond to the CG17667 annotation, but instead corresponds to the "Atg1" gene. The information about "Pegarn" has thus been included under the "Atg1" gene, and the gene corresponding to the CG17667 annotation has been renamed CG42709 in release 5.26 of the genome annotation to avoid confusion. (FlyBase Genome Annotators, 2010) Source for merge of Atg1 anon-WO0118547.287 was sequence comparison (date:051113). (FlyBase, 1996-) Source for merge of l(3)00305 CG10967 was a shared cDNA (date:030206). (FlyBase, 1996-)
Other Comments
	Neuromuscular junction overgrowth caused by Atg1 overexpression is primarily caused by elevated levels of autophagy. (Shen and Ganetzky, 2009) unc-51 genetically interacts with Khc and Unc-76. (Mochizuki et al., 2006) Loss of function of unc-51 results in a reduced rate of locomotion. (Mochizuki et al., 2006) When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, a whole range of mitotic abnormalities, spindle abnormalities, centrosome abnormalities, chromosome abnormalities are seen. (Bettencourt-Dias et al., 2004) Disruption of Atg1 or Atg5 prevents induction of autophagy in response to starvation. (Scott et al., 2004) This protein has 58% identities and 71% similarities to the C.elegans protein kinase unc-51 and 40% identities and 50% similarities with human ULK-1. Using an antibody against a unc-51-GST fusion protein, fluorescence staining in the third instar larvae brains show staining in the motor axons extending from the central nervous system. (Ahantarig et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Area matching Drosophila EST AI062265. This EST forms a1475bp contig with ESTs AA694862 and AI064128 and has sequence similarity to C. elegans UNC51 gene. Probable intron in gene represented by EST AI062265. (Davies, 2001.3.15) Area matching Drosophila EST AA539224 (inverted). (Davies, 2001.3.15)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140344 NM_001169962 RefSeq (Proteins) • NP_648601 NP_001163433 DDBJ / EMBL / GenBank • AA539224 AAF49878 AAM76187 AAX33488 ACZ94704 AI062265 AQ025204 AQ025215 AQ073934 AQ254741 AW942504 AX094163 AX094254 AY129445 BH614852 BT021340 BZ286274 CL528008 CL705841 CZ467034 CZ467035 CZ468715 CZ469112 CZ472799 CZ476515 CZ477318 CZ479589 CZ490807 CZ490808 G00463 Entrez Gene - A searchable database of RefSeq genes. • 39454 UniProtKB/TrEMBL • Q8MQJ7 Q9VU14
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Serine/threonine-protein kinase Unc-51 (IPR017184) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442) Serine/threonine-protein kinase, C-terminal (IPR022708)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64801 DroID - A comprehensive database of gene and protein interactions. • FBgn0260945 DRSC - Results from RNAi screens. • FBgn0260945 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0260945 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0260945 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39454 InParanoid A subset of ortholog calls from InParanoid. • AAEL003819-PA Aedes aegypti (mosquito) AGAP011295-PA Anopheles gambiae (mosquito) XP_624950.1 Apis mellifera (honey bee) XP_001944514.1 Acyrthosiphon pisum (pea aphid) At2g37840.1 Arabidopsis thaliana (wall cress) BGIBMGA005492-PA Bombyx mori (silk worm) ENSBTAP00000017268 Bos taurus (bovine) CN19755 Caenorhabditis brenneri (small nematode) CBP28157 Caenorhabditis briggsae (nematode) CE24516 Caenorhabditis elegans (worm) ENSCAFP00000026786 Canis familiaris (dog) CAGL0L06006g Candida glabrata (haploid yeast) JA11795 Caenorhabditis japonica (nematode) cn09073 Cryptococcus neoformans (yeast-like fungus) CPIJ001273 Culex pipens (mosquito) ENSCPOP00000009021 Cavia porcellus (guinea pig) RP28066 Caenorhabditis remanei (nematode) 170802 Capitella spl (polychaete worm) DDB0185178 Dictyostelium discoideum (amoeba) DEHA2D12452g Debaryomyces Hansenii (yeast) 101872 Daphnia pulex (daphnia) ENSDARP00000083843 Danio rerio (zebra fish) ENSECAP00000014390 Equus caballus (horse) ENSGACP00000017889 Gymnopilus aculeatus (mushroom) ENSGALP00000007513 Gallus gallus (chicken) ENSP00000354877 Homo sapiens (human) ISCW007457-PA Ixodes scapularis (deer tick) 34023 Monocosta brevicollis (choanoflagellate) ENSMODP00000005348 Monodelphis domestica (gray opossum) ENSMMUP00000027852 Macaca mulatta (rhesus monkey) ENSMUSP00000004920 Mus musculus (house mouse) XP_001607390.1 Nasonia vitripennis (wasp) ENSORLP00000013892 Oryzias latipes (japanese killifish) PHUM002890-PA Pediculus humanus (human body louse) PP26225 Pristionchus pacificus (nematode) 201085 Physcomitrella patens (moss) ENSPPYP00000009920 Pongo pygmaeus (orangutan) 572478 Populus trichocarpa (black cottonwood) ENSPTRP00000042372 Pan troglodytes (chimpanzee) ENSRNOP00000003792 Rattus norvegicus (norway rat) YGL180W Saccharomyces cerevisiae (budding yeast) Smp_157350 Schistosoma mansoni (trematode parasite) SPCC63.08c Schizosaccharomyces pombe (fission yeast) XP_798577.2 Strongylocentrotus purpuratus (purple sea urchin) XP_970539.1 Tribolium castaneum (red flour beetle) Tc00.1047053510285.70 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000017404 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000029855 Takifugu rubripes (pufferfish Takifugu) 3692.m00138 Tetrahymena thermophila (ciliate protozoa) YALI0D25388g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/atg1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39454 modMine - Data generated by the modENCODE project. • FBgn0260945 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11803 LH18738 ISCW007457 FBgn0237419 FBgn0219358 FBgn0201202 FBgn0184423 FBgn0184422 FBgn0179492 JGI_V11_101872 FBgn0070731 FBgn0160487 FBgn0136406 FBgn0121971 FBgn0106066 FBgn0087906 CPIJ001273 BGIBMGA005492 ACYPI000902 GB16313 AGAP011295 AAEL016987 AAEL003819 PB25017 PB25018 PHUM233660 GLEAN_05477
Synonyms & Secondary IDs ( 18 )
Reported As
Symbol Synonym	anon-WO0118547.287   atg1 (Nezis et al., 2009, Simonsen et al., 2007, Shelly et al., 2009, Wang et al., 2009, Shen and Ganetzky, 2009, Nezis et al., 2010) Atg1 (Kadandale et al., 2010, Christensen et al., 2009.2.28, Dutta and Baehrecke, 2008, Wairkar et al., 2009, Löw et al., 2007, Berry and Baehrecke, 2007, Kadandale and Kiger, 2008, Chang and Neufeld, 2008, Farkas et al., 2008, Song et al., 2008, Christensen et al., 2008.9.29, Hou et al., 2008, Scott et al., 2007, Ling et al., 2009, Scott et al., 2007, Chang and Neufeld, 2009, Martin et al., 2007, Chang and Neufeld, 2009, Liu and Lehmann, 2008, Berger et al., 2006, Ravikumar et al., 2006, Denton et al., 2009, Wang et al., 2009, Yano et al., 2008, Bass et al., 2009, Juhász et al., 2008, Bhutkar et al., 2007, Filimonenko et al., 2010, Kim et al., 2010, Batlevi et al., 2010, McPhee et al., 2010, Velichkova et al., 2010, Midorikawa et al., 2010, Barth et al., 2011, Ling and Salvaterra, 2011, Nisoli et al., 2010, Demontis and Perrimon, 2010, Shen and Ganetzky, 2009) ATG1 (Cao et al., 2008, Scott, 2005.3.2, Scott et al., 2005, Kim et al., 2008, Lee et al., 2007, Wu et al., 2009, Lee et al., 2010, Siegrist et al., 2010) CG10967 (Bettencourt-Dias et al., 2004, Scott et al., 2004, Bidet, 2003, van Steensel et al., 2003, Borras, 2003, Giot et al., 2003, Grieder et al., 2007, Toda et al., 2008, Perkins et al., 2009.3.31, Lee et al., 2007, Bhutkar et al., 2007, Tomancak et al., 2007, Ling and Salvaterra, 2011, Ni et al., 2011.7.19) dATG1 (Lee et al., 2010) DK-4 (Ahantarig et al., 2003, Ahantarig et al., 2001, ) DmATG1 (Lee et al., 2007) l(3)00305 (Birchler et al., 2001, FlyBase, 1996-, Spradling et al., 1999, BDGP Project Members, 1994-1999, Davies et al., 2001, Liebl et al., 2006, Grieder et al., 2007, Beckstead et al., 2005) ULK1 (Kadandale et al., 2010) unc-51 (Wairkar et al., 2009, Toda et al., 2008, ) Unc-51 (Wairkar et al., 2009) unc51 (Mochizuki et al., 2006) UNC 51-like (Morrison et al., 2000)
Name Synonym	Autophagy-specific gene 1 (Scott et al., 2004, Scott et al., 2004, Scott et al., 2005, Lee et al., 2007, Bass et al., 2009, Ling and Salvaterra, 2011) autophagy-specific gene1 (Ling et al., 2009) Pegarn (Ahantarig et al., 2009) uncoordinated movement-51 (Ahantarig et al., 2003)
Secondary FlyBase IDs
	FBgn0010715 FBgn0036313 FBgn0044321 FBgn0062118 FBgn0064136
References ( 99 )
Generate a list of	All references relating to this gene ( 99 )
List References by type	Research paper  ( 54 ) Supplementary material  ( 9 ) Review  ( 1 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 11 ) FlyBase analysis  ( 4 ) Computer file  ( 4 ) Patent  ( 1 ) DNA/RNA sequence record  ( 2 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 17 )
	Barth et al., 2011, Cell Death Differ. 18(6): 915--924 Autophagy in Drosophila ovaries is induced by starvation and is required for oogenesis. [FBrf0213616] Ling and Salvaterra, 2011, PLoS ONE 6(3): e17762 Robust RT-qPCR Data Normalization: Validation and Selection of Internal Reference Genes during Post-Experimental Data Analysis. [FBrf0213272] Ribeiro et al., 2011, PLoS Genet. 7(2): e1001295 Phosphoinositide regulation of integrin trafficking required for muscle attachment and maintenance. [FBrf0213137] Tanner et al., 2011, Development 138(2): 327--338 Bcl-2 proteins and autophagy regulate mitochondrial dynamics during programmed cell death in the Drosophila ovary. [FBrf0212552] Batlevi et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(2): 742--747 Dynein light chain 1 is required for autophagy, protein clearance, and cell death in Drosophila. [FBrf0209730] Demontis and Perrimon, 2010, Cell 143(5): 813--825 FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging. [FBrf0212347] Filimonenko et al., 2010, Mol. Cell 38(2): 265--279 The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy. [FBrf0210639] Kadandale et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(23): 10502--10507 Conserved role for autophagy in Rho1-mediated cortical remodeling and blood cell recruitment. [FBrf0210996] Kim et al., 2010, BMC Cell Biol. 11: 9 A genetic screen for modifiers of Drosophila caspase Dcp-1 reveals caspase involvement in autophagy and novel caspase-related genes. [FBrf0209948] Lee et al., 2010, Science 327(5970): 1223--1228 Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. [FBrf0210161] McPhee et al., 2010, Nature 465(7301): 1093--1096 Activation of autophagy during cell death requires the engulfment receptor Draper. [FBrf0211145] Midorikawa et al., 2010, J. Neurosci. 30(32): 10703--10719 Autophagy-dependent rhodopsin degradation prevents retinal degeneration in Drosophila. [FBrf0211516] Nezis et al., 2010, J. Cell Biol. 190(4): 523--531 Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late Drosophila melanogaster oogenesis. [FBrf0211647] Nisoli et al., 2010, Cell Death Differ. 17(10): 1577--1587 Neurodegeneration by polyglutamine Atrophin is not rescued by induction of autophagy. [FBrf0212035] Siegrist et al., 2010, Curr. Biol. 20(7): 643--648 Inactivation of both foxo and reaper promotes long-term adult neurogenesis in Drosophila. [FBrf0210555] Velichkova et al., 2010, J. Cell Biol. 190(3): 407--425 Drosophila Mtm and class II PI3K coregulate a PI(3)P pool with cortical and endolysosomal functions. [FBrf0211470] Willis et al., 2010, J. Insect Sci. 10: 66 Microarray Analysis of Juvenile Hormone Response in Drosophila melanogaster S2 cells. [FBrf0211402] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...