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Gene Dmel\asl

General Information
Symbol	Dmel\asl	Species	D. melanogaster
Name	asterless	Annotation symbol	CG2919
Feature type	protein_coding_gene	FlyBase ID	FBgn0261004
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map	3-47.5
Cytogenetic map	83B4-83B5	Sequence location	3R:1,428,949..1,432,244 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene asterless is referred to in FlyBase by the symbol Dmel\asl (CG2919, FBgn0261004). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: centrosome organization; sensory perception of mechanical stimulus; centrosome cycle; sperm axoneme assembly; centriole replication; nonmotile primary cilium assembly; asymmetric cell division; single fertilization. 15 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organelle; multicellular structure; intracellular organelle part; elongation stage spermatid; cytoplasmic part; adult segment; spindle; organ system subdivision; intracellular non-membrane-bounded organelle; centrosome. It has one annotated transcript and one annotated polypeptide. Protein features are: Prefoldin. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval trachea, adult ovary, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1625999_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of asl. Gene sequence location is 3R:1428949..1432244.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	References Pollarolo et al., 2011, Nat. Neurosci. 14(12): 1525--1533 Gopalakrishnan et al., 2011, Nat. Commun. 2: 359 Dzhindzhev et al., 2010, Nature 467(7316): 714--718 Sequence features HFA12319 BKN25788
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 83B4-83B5   Limits computationally determined from genome sequence between P{PZ}Snr101319&P{PZ}Itp-r83A05616 and P{lacW}Atus1938
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	3-47.5   3- (Giansanti et al., 1991)
Left of (cM)	P{EP}RgaEP3713 (Varmark et al., 2007) Ki (Bonaccorsi et al., 1996, Bonaccorsi et al., 1998) cu (Giansanti et al., 1991)
Right of (cM)	st (Giansanti et al., 1991) P{EP}exbaEP3591 (Varmark et al., 2007)
Notes	Mapped halfway between st and cu. (Giansanti et al., 1991)
Gene Model & Products
Please see the GBrowse view of Dmel\asl for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) asl-RA FBtr0078743  NM_141300   3175   994
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein asl-PA   FBpp0078392   116.6   994   5.90     NP_649557   AAF51993
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Prefoldin (IPR009053)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA263789   AA391853   AA940719   AA941965   AA978992   AE014297 AAF51993   AI064675   AI401885   AI517866   AI530765   AI530903   AI533402   BG634388   BG637259   BI167245   BI235597   BI239179   BI353632   BP541422   BT010112 AAQ22581   CK604985   CO280315   CO316966   EC066532   EC226894   EC245217
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VNE4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0261004    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0261004 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0261004 expression level Developmental Stage   Expression Level embryo 00-02hr    2851 embryo 02-04hr    4085 embryo 04-06hr    3996 embryo 06-08hr    3426 embryo 08-10hr    2569 embryo 10-12hr    1074 embryo 12-14hr    1192 embryo 14-16hr    815 embryo 16-18hr    686 embryo 18-20hr    411 embryo 20-22hr    1258 embryo 22-24hr    1191 larva L1    209 larva L2    241 larva L3 12hr old    218 larva L3 puffstage 1-2    396 larva L3 puffstage 3-6    625 larva L3 puffstage 7-9    786 white prepupae new    804 white prepupae 12hr    974 white prepupae 24hr    1081 pupae 2d postWPP    705 pupae 3d postWPP    539 pupae 4d postWPP    415 adult male 01day    603 adult male 05day    827 adult male 30day    707 adult female 01day    787 adult female 05day    1849 adult female 30day    1897 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2851) embryo 02-04hr  (4085) embryo 04-06hr  (3996) embryo 06-08hr  (3426) embryo 08-10hr  (2569) embryo 10-12hr  (1074) embryo 12-14hr  (1192) embryo 14-16hr  (815) embryo 16-18hr  (686) embryo 18-20hr  (411) embryo 20-22hr  (1258) embryo 22-24hr  (1191) larva L1  (209) larva L2  (241) larva L3 12hr old  (218) larva L3 puffstage 1-2  (396) larva L3 puffstage 3-6  (625) larva L3 puffstage 7-9  (786) white prepupae new  (804) white prepupae 12hr  (974) white prepupae 24hr  (1081) pupae 2d postWPP  (705) pupae 3d postWPP  (539) pupae 4d postWPP  (415) adult male 01day  (603) adult male 05day  (827) adult male 30day  (707) adult female 01day  (787) adult female 05day  (1849) adult female 30day  (1897) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2851) embryo 02-04hr  (4085) embryo 04-06hr  (3996) embryo 06-08hr  (3426) embryo 08-10hr  (2569) embryo 10-12hr    1074 embryo 12-14hr    1192 embryo 14-16hr    815 embryo 16-18hr    686 embryo 18-20hr    411 embryo 20-22hr    1258 embryo 22-24hr    1191 larva L1    209 larva L2    241 larva L3 12hr old    218 larva L3 puffstage 1-2    396 larva L3 puffstage 3-6    625 larva L3 puffstage 7-9    786 white prepupae new    804 white prepupae 12hr    974 white prepupae 24hr    1081 pupae 2d postWPP    705 pupae 3d postWPP    539 pupae 4d postWPP    415 adult male 01day    603 adult male 05day    827 adult male 30day    707 adult female 01day    787 adult female 05day  (1849) adult female 30day  (1897) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2851 embryo 02-04hr    4085 embryo 04-06hr    3996 embryo 06-08hr    3426 embryo 08-10hr    2569 embryo 10-12hr    1074 embryo 12-14hr    1192 embryo 14-16hr    815 embryo 16-18hr    686 embryo 18-20hr    411 embryo 20-22hr    1258 embryo 22-24hr    1191 larva L1    209 larva L2    241 larva L3 12hr old    218 larva L3 puffstage 1-2    396 larva L3 puffstage 3-6    625 larva L3 puffstage 7-9    786 white prepupae new    804 white prepupae 12hr    974 white prepupae 24hr    1081 pupae 2d postWPP    705 pupae 3d postWPP    539 pupae 4d postWPP    415 adult male 01day    603 adult male 05day    827 adult male 30day    707 adult female 01day    787 adult female 05day    1849 adult female 30day    1897 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2851 embryo 02-04hr    4085 embryo 04-06hr    3996 embryo 06-08hr    3426 embryo 08-10hr    2569 embryo 10-12hr    1074 embryo 12-14hr    1192 embryo 14-16hr    815 embryo 16-18hr    686 embryo 18-20hr    411 embryo 20-22hr    1258 embryo 22-24hr    1191 larva L1    209 larva L2    241 larva L3 12hr old    218 larva L3 puffstage 1-2    396 larva L3 puffstage 3-6    625 larva L3 puffstage 7-9    786 white prepupae new    804 white prepupae 12hr    974 white prepupae 24hr    1081 pupae 2d postWPP    705 pupae 3d postWPP    539 pupae 4d postWPP    415 adult male 01day    603 adult male 05day    827 adult male 30day    707 adult female 01day    787 adult female 05day    1849 adult female 30day    1897 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0261004 expression level Developmental Stage   Expression Level embryo 00-02hr    2851 embryo 02-04hr    4085 embryo 04-06hr    3996 embryo 06-08hr    3426 embryo 08-10hr    2569 embryo 10-12hr    1074 embryo 12-14hr    1192 embryo 14-16hr    815 embryo 16-18hr    686 embryo 18-20hr    411 embryo 20-22hr    1258 embryo 22-24hr    1191 larva L1    209 larva L2    241 larva L3 12hr old    218 larva L3 puffstage 1-2    396 larva L3 puffstage 3-6    625 larva L3 puffstage 7-9    786 white prepupae new    804 white prepupae 12hr    974 white prepupae 24hr    1081 pupae 2d postWPP    705 pupae 3d postWPP    539 pupae 4d postWPP    415 adult male 01day    603 adult male 05day    827 adult male 30day    707 adult female 01day    787 adult female 05day    1849 adult female 30day    1897 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2851) embryo 02-04hr  (4085) embryo 04-06hr  (3996) embryo 06-08hr  (3426) embryo 08-10hr  (2569) embryo 10-12hr  (1074) embryo 12-14hr  (1192) embryo 14-16hr  (815) embryo 16-18hr  (686) embryo 18-20hr  (411) embryo 20-22hr  (1258) embryo 22-24hr  (1191) larva L1  (209) larva L2  (241) larva L3 12hr old  (218) larva L3 puffstage 1-2  (396) larva L3 puffstage 3-6  (625) larva L3 puffstage 7-9  (786) white prepupae new  (804) white prepupae 12hr  (974) white prepupae 24hr  (1081) pupae 2d postWPP  (705) pupae 3d postWPP  (539) pupae 4d postWPP  (415) adult male 01day  (603) adult male 05day  (827) adult male 30day  (707) adult female 01day  (787) adult female 05day  (1849) adult female 30day  (1897) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2851) embryo 02-04hr  (4085) embryo 04-06hr  (3996) embryo 06-08hr  (3426) embryo 08-10hr  (2569) embryo 10-12hr    1074 embryo 12-14hr    1192 embryo 14-16hr    815 embryo 16-18hr    686 embryo 18-20hr    411 embryo 20-22hr    1258 embryo 22-24hr    1191 larva L1    209 larva L2    241 larva L3 12hr old    218 larva L3 puffstage 1-2    396 larva L3 puffstage 3-6    625 larva L3 puffstage 7-9    786 white prepupae new    804 white prepupae 12hr    974 white prepupae 24hr    1081 pupae 2d postWPP    705 pupae 3d postWPP    539 pupae 4d postWPP    415 adult male 01day    603 adult male 05day    827 adult male 30day    707 adult female 01day    787 adult female 05day  1849 adult female 30day  1897 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2851 embryo 02-04hr    4085 embryo 04-06hr    3996 embryo 06-08hr    3426 embryo 08-10hr    2569 embryo 10-12hr    1074 embryo 12-14hr    1192 embryo 14-16hr    815 embryo 16-18hr    686 embryo 18-20hr    411 embryo 20-22hr    1258 embryo 22-24hr    1191 larva L1    209 larva L2    241 larva L3 12hr old    218 larva L3 puffstage 1-2    396 larva L3 puffstage 3-6    625 larva L3 puffstage 7-9    786 white prepupae new    804 white prepupae 12hr    974 white prepupae 24hr    1081 pupae 2d postWPP    705 pupae 3d postWPP    539 pupae 4d postWPP    415 adult male 01day    603 adult male 05day    827 adult male 30day    707 adult female 01day    787 adult female 05day    1849 adult female 30day    1897 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2851 embryo 02-04hr    4085 embryo 04-06hr    3996 embryo 06-08hr    3426 embryo 08-10hr    2569 embryo 10-12hr    1074 embryo 12-14hr    1192 embryo 14-16hr    815 embryo 16-18hr    686 embryo 18-20hr    411 embryo 20-22hr    1258 embryo 22-24hr    1191 larva L1    209 larva L2    241 larva L3 12hr old    218 larva L3 puffstage 1-2    396 larva L3 puffstage 3-6    625 larva L3 puffstage 7-9    786 white prepupae new    804 white prepupae 12hr    974 white prepupae 24hr    1081 pupae 2d postWPP    705 pupae 3d postWPP    539 pupae 4d postWPP    415 adult male 01day    603 adult male 05day    827 adult male 30day    707 adult female 01day    787 adult female 05day    1849 adult female 30day    1897 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0261004    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0261004 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval trachea, adult ovary, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0261004 expression level Tissue   Expression Level Larval Central Nervous System    150.525 Larval Midgut    31 Larval Hindgut    49 Larval Malpighian Tubules    31.1 Larval Fat Body    65.5 Larval Salivary Gland    71.4 Larval Trachea    110.1 Larval Carcass    73.5 Adult Head no informative data Adult Eye no informative data Adult Brain    34.3 Adult Thoracic-Abdominal Ganglion    23.2 Adult Crop    44.1 Adult Midgut no informative data Adult Hindgut    27.7 Adult Malpighian Tubules no informative data Adult Fat Body    24.3 Adult Salivary Gland no informative data Adult Heart    47.4 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    205.4 Adult Testis    199.9 Adult Male Accessory Gland    24.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    150.525 Larval Midgut    31 Larval Hindgut    49 Larval Malpighian Tubules    31.1 Larval Fat Body    65.5 Larval Salivary Gland    71.4 Larval Trachea    110.1 Larval Carcass    73.5 Adult Head no informative data Adult Eye no informative data Adult Brain    34.3 Adult Thoracic-Abdominal Ganglion    23.2 Adult Crop    44.1 Adult Midgut no informative data Adult Hindgut    27.7 Adult Malpighian Tubules no informative data Adult Fat Body    24.3 Adult Salivary Gland no informative data Adult Heart    47.4 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    205.4 Adult Testis    199.9 Adult Male Accessory Gland    24.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    150.525 Larval Midgut    31 Larval Hindgut    49 Larval Malpighian Tubules    31.1 Larval Fat Body    65.5 Larval Salivary Gland    71.4 Larval Trachea    110.1 Larval Carcass    73.5 Adult Head no informative data Adult Eye no informative data Adult Brain    34.3 Adult Thoracic-Abdominal Ganglion    23.2 Adult Crop    44.1 Adult Midgut no informative data Adult Hindgut    27.7 Adult Malpighian Tubules no informative data Adult Fat Body    24.3 Adult Salivary Gland no informative data Adult Heart    47.4 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    205.4 Adult Testis    199.9 Adult Male Accessory Gland    24.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    150.525 Larval Midgut    31 Larval Hindgut    49 Larval Malpighian Tubules    31.1 Larval Fat Body    65.5 Larval Salivary Gland    71.4 Larval Trachea    110.1 Larval Carcass    73.5 Adult Head no informative data Adult Eye no informative data Adult Brain    34.3 Adult Thoracic-Abdominal Ganglion    23.2 Adult Crop    44.1 Adult Midgut no informative data Adult Hindgut    27.7 Adult Malpighian Tubules no informative data Adult Fat Body    24.3 Adult Salivary Gland no informative data Adult Heart    47.4 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    205.4 Adult Testis    199.9 Adult Male Accessory Gland    24.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0261004 expression level Tissue   Expression Level Larval Central Nervous System    150.525 Larval Midgut    31 Larval Hindgut    49 Larval Malpighian Tubules    31.1 Larval Fat Body    65.5 Larval Salivary Gland    71.4 Larval Trachea    110.1 Larval Carcass    73.5 Adult Head no informative data Adult Eye no informative data Adult Brain    34.3 Adult Thoracic-Abdominal Ganglion    23.2 Adult Crop    44.1 Adult Midgut no informative data Adult Hindgut    27.7 Adult Malpighian Tubules no informative data Adult Fat Body    24.3 Adult Salivary Gland no informative data Adult Heart    47.4 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    205.4 Adult Testis    199.9 Adult Male Accessory Gland    24.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    150.525 Larval Midgut    31 Larval Hindgut    49 Larval Malpighian Tubules    31.1 Larval Fat Body    65.5 Larval Salivary Gland    71.4 Larval Trachea    110.1 Larval Carcass    73.5 Adult Head no informative data Adult Eye no informative data Adult Brain    34.3 Adult Thoracic-Abdominal Ganglion    23.2 Adult Crop    44.1 Adult Midgut no informative data Adult Hindgut    27.7 Adult Malpighian Tubules no informative data Adult Fat Body    24.3 Adult Salivary Gland no informative data Adult Heart    47.4 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    205.4 Adult Testis    199.9 Adult Male Accessory Gland    24.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    150.525 Larval Midgut    31 Larval Hindgut    49 Larval Malpighian Tubules    31.1 Larval Fat Body    65.5 Larval Salivary Gland    71.4 Larval Trachea    110.1 Larval Carcass    73.5 Adult Head no informative data Adult Eye no informative data Adult Brain    34.3 Adult Thoracic-Abdominal Ganglion    23.2 Adult Crop    44.1 Adult Midgut no informative data Adult Hindgut    27.7 Adult Malpighian Tubules no informative data Adult Fat Body    24.3 Adult Salivary Gland no informative data Adult Heart    47.4 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    205.4 Adult Testis    199.9 Adult Male Accessory Gland    24.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    150.525 Larval Midgut    31 Larval Hindgut    49 Larval Malpighian Tubules    31.1 Larval Fat Body    65.5 Larval Salivary Gland    71.4 Larval Trachea    110.1 Larval Carcass    73.5 Adult Head no informative data Adult Eye no informative data Adult Brain    34.3 Adult Thoracic-Abdominal Ganglion    23.2 Adult Crop    44.1 Adult Midgut no informative data Adult Hindgut    27.7 Adult Malpighian Tubules no informative data Adult Fat Body    24.3 Adult Salivary Gland no informative data Adult Heart    47.4 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    205.4 Adult Testis    199.9 Adult Male Accessory Gland    24.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head no informative data Adult Eye no informative data Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    no informative data   NA  Brain    34.3   150.525  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    23.2   NA  Crop    44.1   31  Midgut    no informative data   49  Hindgut    27.7   31.1  Malpighian Tubules    no informative data   65.5  Fat Body    24.3   71.4  Salivary Gland    no informative data   NA  Heart    47.4   110.1  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    205.4   NA  Testis    199.9   NA  Male Accessory Gland    24.9   73.5  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0261004
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 aslGD9853 lethal (with asl2) asl3 lethal (with asl3) asl2 lethal | recessive asl2 viable aslc01524 viable, with Scer\GAL4pnr-MD237 aslGD9853 viable (with asl1) asl2 asl3 viable (with asl2) asl1 viable (with asl3) asl1 Sterility Allele female sterile | recessive asl1 fertile aslc01524 male sterile asl1 male sterile | recessive asl1 Other Phenotypes Allele cell polarity defective asl3 cytokinesis defective | male | recessive asl1 meiotic cell cycle defective asl1 meiotic cell cycle defective | recessive asl1 uncoordinated | adult stage aslmecD Phenotype manifest in Allele anaphase & condensed nuclear chromosome asl2 anaphase & condensed nuclear chromosome (with asl2) asl3 anaphase & condensed nuclear chromosome (with asl3) asl2 aster asl1 asl2 aster & spermatocyte aslunspecified centriole asl1 centriole, with Scer\GAL4mat.αTub67C.T:Hsim\VP16 aslScer\UAS.P\T.T:Avic\GFP centrosome asl1 asl2 centrosome (with asl2) asl3 centrosome (with asl3) asl2 centrosome & spermatocyte aslunspecified cilium & mechanosensory sensory organ aslmecD embryonic/larval brain | larval stage, with Scer\GAL41407 aslGD9853 larval brain & ganglion mother cell asl2 larval brain & ganglion mother cell (with asl2) asl3 larval brain & ganglion mother cell (with asl3) asl2 larval brain & ganglion mother cell & aster asl2 larval brain & ganglion mother cell & aster (with asl2) asl3 larval brain & ganglion mother cell & aster (with asl3) asl2 larval brain & ganglion mother cell & centrosome asl2 larval brain & ganglion mother cell & centrosome (with asl2) asl3 larval brain & ganglion mother cell & centrosome (with asl3) asl2 larval brain & neuroblast asl2 larval brain & neuroblast (with asl2) asl3 larval brain & neuroblast (with asl3) asl2 larval brain & neuroblast & aster asl2 aslunspecified larval brain & neuroblast & aster (with asl2) asl3 larval brain & neuroblast & aster (with asl3) asl2 larval brain & neuroblast & centrosome asl2 aslunspecified larval brain & neuroblast & centrosome (with asl2) asl3 larval brain & neuroblast & centrosome (with asl3) asl2 larval brain & neuroblast & spindle aslunspecified leg aslmecD meiosis I asl1 meiotic anaphase I & nuclear chromosome aslunspecified meiotic anaphase I | male asl1 meiotic cell cycle & spermatocyte aslunspecified meiotic cell cycle & spindle | male aslunspecified meiotic metaphase I | male asl1 microtubule asl2 microtubule (with asl2) asl3 microtubule (with asl3) asl2 microtubule basal body & mechanosensory sensory organ aslmecD microtubule basal body & spermatid aslmecD microtubule basal body & spermatocyte (with Df(3R)ED5177) asl1 asl2 asl3 mitosis & nuclear chromosome asl2 mitosis & nuclear chromosome (with asl2) asl3 mitosis & nuclear chromosome (with asl3) asl2 Nebenkern derivative asl1 aslmecD neuroblast & nucleus asl2 neuroblast & nucleus (with asl2) asl3 neuroblast & nucleus (with asl3) asl2 onion stage spermatid asl1 onion stage spermatid & nucleus asl1 spermatid asl1 spermatid axoneme aslmecD spermatocyte asl1 spermatocyte & aster asl1 asl2 aslunspecified spermatocyte & aster (with asl1) asl2 asl3 spermatocyte & aster (with asl2) asl1 asl3 spermatocyte & aster (with asl3) asl1 asl2 spermatocyte & spindle aslunspecified spindle asl1 spindle & spermatocyte aslunspecified wing aslmecD
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of asl Class Mutagen Stocks Known lesion aslc01524 piggyBac transposase 2 -- aslmecD amorphic allele - genetic evidence 0 Yes asl1 ethyl methanesulfonate 0 Yes asl2 ethyl methanesulfonate 0 Yes asl3 ethyl methanesulfonate 0 Yes aslunspecified 0 --
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of asl Class Mutagen Stocks Known lesion aslGD9853 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes aslHMS01453 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes asl+tGR in vitro construct - genomic fragment 0 Yes aslD44.Ubi-p63E.T:Avic\GFP-EYFP in vitro construct - regulatory fusion 0 Yes aslFL.Ubi-p63E.T:Avic\GFP-EYFP in vitro construct - regulatory fusion 0 Yes aslScer\UAS.P\T.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes aslT:Avic\GFP in vitro construct - coding region fusion 0 Yes aslUbi.S.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes aslUbi.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6144 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{TRiP.HMS01453} NA P{UASp-asl-GFP} NA characterization construct P{asl+tGR} NA P{asl-GFP.B} NA P{Ubi-asl-GFP.S} NA P{Ubi-asl-GFP} NA P{Ubi-YFP-asl.D44} NA P{Ubi-YFP-asl.FL} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{PB}aslc01524 NA
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 12 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
asymmetric cell division inferred from direct assay (Januschke and Gonzalez, 2010) centriole replication inferred from mutant phenotype (Dobbelaere et al., 2008, Blachon et al., 2008) centrosome cycle inferred from mutant phenotype (Bonaccorsi et al., 2000) centrosome organization inferred from mutant phenotype (Varmark et al., 2007) nonmotile primary cilium assembly inferred from mutant phenotype (Blachon et al., 2008) sensory perception of mechanical stimulus inferred from mutant phenotype (Avidor-Reiss et al., 2001) single fertilization inferred from mutant phenotype (Varmark et al., 2007) sperm axoneme assembly inferred from mutant phenotype (Blachon et al., 2008)
Cellular Component
CV term Evidence References
colocalizes_with centriole inferred from direct assay (Blachon et al., 2008) centriole inferred from direct assay (Varmark et al., 2007) centrosome inferred from direct assay (Blachon et al., 2008) microtubule basal body inferred from direct assay (Varmark et al., 2007) pericentriolar material inferred from direct assay (Blachon et al., 2008)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions asl allele Gene References asl2 asp (Wakefield et al., 2001)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65888 DroID - A comprehensive database of gene and protein interactions. • FBgn0261004 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40682
Orthologs
Genome-wide drosophilid orthologs	Dana\GF18661 Dere\GG10928 Dgri\GH17547 Dmoj\GI22525 Dper\GL23026 Dpse\GA26457 Dsec\GM10613 Dsim\GD19601 Dvir\GJ10129 Dwil\GK14076 Dyak\GE24157
Curated drosophilid orthologs	Dpse\GA15519
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL012031-PA Aedes aegypti (mosquito) AGAP003526-PA Anopheles gambiae (mosquito) BGIBMGA010138-PA Bombyx mori (silk worm) ENSCINP00000013334 Ciona intestinalis (sea squirt) CPIJ006753 Culex pipens (mosquito) PHUM006357-PA Pediculus humanus (human body louse) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV21604 LH14240 FBgn0241290 FBgn0216082 FBgn0197417 FBgn0177997 FBgn0165559 JGI_V11_307378 FBgn0247831 FBgn0160616 FBgn0145253 FBgn0125017 FBgn0103231 FBgn0095679 CPIJ013155 CPIJ006753 BGIBMGA010138 ACYPI31977 GB11327 AGAP003526 AAEL012031 PB19561 PHUM050590 GLEAN_03499 GLEAN_14768
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	10582 w1118; PBac{PB}aslc01524 35039 y1 sc* v1; P{TRiP.HMS01453}attP2
Harvard	- PBac{PB}aslc01524
VDRC	v25457 w1118; P{GD9853}v25457
Genomic Clones ( 2 )
	BACR03P13 BACR24O24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 23 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH02902
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT30584 GM24514 LD06941 LD22868 LD27332 LD33225 LD42985 RE07581 RE31482 RE35602 SD01345 SD01672 SD05201 SD15164
Other clones	40323 161804 161838 EK153722 EK266454 FGC001E02 LD10792 UT01592
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0261004 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40682 250471
Antibody Information
	polyclonal (Conduit et al., 2010, Blachon et al., 2008, Stevens et al., 2009, Dzhindzhev et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: asl CG2919 (Varmark et al., 2007) Source for merge of: asl mecD (Blachon et al., 2008)
Additional comments
Other Comments
	asl protein is closely associated with the centriole wall, but is not part of the centriole structure. (Blachon et al., 2008) asl is required for centriole duplication. (Blachon et al., 2008) asl is involved in centriole duplication and is required for efficient recruitment of pericentriolar material. (Dobbelaere et al., 2008) Expression is enriched in embryonic gonads. (Shigenobu et al., 2006) Identification: in a genetic screen for mutants defective in mechanosensation. (Avidor-Reiss et al., 2001) Mutants have severe defects in mechanosensory transduction. (Avidor-Reiss et al., 2001) asl is required for aster formation during male meiosis. (Bonaccorsi et al., 1998) Mutants are male sterile with no spindle aster in primary spermatocytes.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141300 RefSeq (Proteins) • NP_649557 DDBJ / EMBL / GenBank • AAF51993 AAQ22581 AI064675 AI401885 BT010112 Entrez Gene - A searchable database of RefSeq genes. • 40682 UniProtKB/TrEMBL • Q9VNE4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Prefoldin (IPR009053)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65888 DroID - A comprehensive database of gene and protein interactions. • FBgn0261004 DRSC - Results from RNAi screens. • FBgn0261004 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0261004 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0261004 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40682 250471 InParanoid A subset of ortholog calls from InParanoid. • AAEL012031-PA Aedes aegypti (mosquito) AGAP003526-PA Anopheles gambiae (mosquito) BGIBMGA010138-PA Bombyx mori (silk worm) ENSCINP00000013334 Ciona intestinalis (sea squirt) CPIJ006753 Culex pipens (mosquito) PHUM006357-PA Pediculus humanus (human body louse) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40682 modMine - Data generated by the modENCODE project. • FBgn0261004 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV21604 LH14240 FBgn0241290 FBgn0216082 FBgn0197417 FBgn0177997 FBgn0165559 JGI_V11_307378 FBgn0247831 FBgn0160616 FBgn0145253 FBgn0125017 FBgn0103231 FBgn0095679 CPIJ013155 CPIJ006753 BGIBMGA010138 ACYPI31977 GB11327 AGAP003526 AAEL012031 PB19561 PHUM050590 GLEAN_03499 GLEAN_14768
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	Asl (Dix and Raff, 2007, Rebollo et al., 2007, Mottier-Pavie and Megraw, 2009, Dix and Raff, 2007, Rebollo et al., 2009, Stevens et al., 2009, Stevens et al., 2010, Conduit et al., 2010, Stevens et al., 2010) asl (Stevens et al., 2010, Varmark et al., 2007, Bonaccorsi et al., 2007, Rusan and Peifer, 2007, Giansanti et al., 2008, Dobbelaere et al., 2008, Castellanos et al., 2008, Blachon et al., 2008, Brodu et al., 2010, Blachon et al., 2009, Januschke and Gonzalez, 2010, Dzhindzhev et al., 2010, Gopalakrishnan et al., 2011) CG2919 (Varmark et al., 2007, Shigenobu et al., 2006, Rebollo et al., 2007, Dobbelaere et al., 2008, Blachon et al., 2008, Ni et al., 2011.7.19) mecD (Blachon et al., 2008) sdu (Giansanti et al., 1991, )
Name Synonym	asterless (Varmark et al., 2007, Blachon et al., 2008) Asterless (Stevens et al., 2009, Stevens et al., 2010, Januschke and Gonzalez, 2010) CG2919   mechanosensory D (Avidor-Reiss et al., 2001) mechanosensory mutant D (Blachon et al., 2008) star dust
Secondary FlyBase IDs
	FBgn0004830 FBgn0004916 FBgn0037348 FBgn0043878 FBgn0259895
References ( 55 )
Generate a list of	All references relating to this gene ( 55 )
List References by type	Research paper  ( 28 ) Supplementary material  ( 3 ) Review  ( 7 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 9 ) FlyBase analysis  ( 1 ) Computer file  ( 1 ) Conference report  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 9 )
	Gopalakrishnan et al., 2011, Nat. Commun. 2: 359 Sas-4 provides a scaffold for cytoplasmic complexes and tethers them in a centrosome. [FBrf0216370] Pollarolo et al., 2011, Nat. Neurosci. 14(12): 1525--1533 Cytokinesis remnants define first neuronal asymmetry in vivo. [FBrf0216761] Brodu et al., 2010, Dev. Cell 18(5): 790--801 A developmentally regulated two-step process generates a noncentrosomal microtubule network in Drosophila tracheal cells. [FBrf0210851] Conduit et al., 2010, Curr. Biol. 20(24): 2178--2186 Centrioles Regulate Centrosome Size by Controlling the Rate of Cnn Incorporation into the PCM. [FBrf0212603] Dzhindzhev et al., 2010, Nature 467(7316): 714--718 Asterless is a scaffold for the onset of centriole assembly. [FBrf0212014] Januschke and Gonzalez, 2010, J. Cell Biol. 188(5): 693--706 The interphase microtubule aster is a determinant of asymmetric division orientation in Drosophila neuroblasts. [FBrf0210175] Kracklauer et al., 2010, J. Cell Sci. 123(Pt 16): 2763--2772 The Drosophila SUN protein Spag4 cooperates with the coiled-coil protein Yuri Gagarin to maintain association of the basal body and spermatid nucleus. [FBrf0211482] Stevens et al., 2010, J. Cell Biol. 188(3): 313--323 Drosophila Ana2 is a conserved centriole duplication factor. [FBrf0209887] Stevens et al., 2010, Dev. Cell 19(6): 913--919 DSas-6 and Ana2 Coassemble into Tubules to Promote Centriole Duplication and Engagement. [FBrf0212508] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...