FB2021_06, released December 14, 2021

Gene: Dmel\Dscam3

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General Information
Symbol
Dmel\Dscam3
Species
D. melanogaster
Name
Down syndrome cell adhesion molecule 3
Annotation Symbol
CG31190
Feature Type
protein_coding_gene
FlyBase ID
FBgn0261046
Gene Model Status
Current
Stock Availability
10 publicly available
Gene Summary
Down syndrome cell adhesion molecule 3 (Dscam3) encodes a large transmembrane protein that functions in homophilic cell adhesion. It may also function as an axon guidance receptor. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
90B1-90B1
Sequence location
Recombination map
3-61
RefSeq locus
NT_033777 REGION:17473935..17505667
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (8 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables identical protein binding
inferred from physical interaction with FLYBASE:Dscam3; FB:FBgn0261046
(Millard et al., 2007)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables cell-cell adhesion mediator activity
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in axon guidance
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in dendrite self-avoidance
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in homophilic cell adhesion via plasma membrane adhesion molecules
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred by curator from GO:0042802
(Millard et al., 2007)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
is_active_in axon
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in integral component of plasma membrane
inferred from electronic annotation with InterPro:IPR033027
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
inferred from sequence model
(Millard et al., 2007)
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Down syndrome cell adhesion molecule 3 (Dscam3) encodes a large transmembrane protein that functions in homophilic cell adhesion. It may also function as an axon guidance receptor. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
DOWN SYNDROME CELL-ADHESION MOLECULES -
The Dscam (Down syndrome cell-adhesion molecule) transmembrane immunoglobulin superfamily proteins regulate axon branching and guidance by mediating both repulsion and adhesion. (Adapted from FBrf0232776, FBrf0145178 and FBrf0193992).
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
4

Please see the JBrowse view of Dmel\Dscam3 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.44

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
(Millard et al., 2007)
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Dscam3-RC
FBtr0113397
NM_001104355
8231
2007
Dscam3-RD
FBtr0113398
NM_001104356
3712
1006
Dscam3-RE
FBtr0330211
NM_206504
7656
2087
Dscam3-RF
FBtr0330212
NM_169761
7745
2077
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Dscam3-PC
FBpp0112309
219.7
2007
7.93
NP_001097825
ABW08696
Dscam3-PD
FBpp0112310
111.4
1006
8.07
NP_001097826
ABW08697
Dscam3-PE
FBpp0303244
228.3
2087
7.23
NP_996226
AAS65164
Dscam3-PF
FBpp0303245
226.9
2077
7.26
NP_732242
AAF55426
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dscam3 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Dscam3 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 11 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Dscam3
Transgenic constructs containing regulatory region of Dscam3
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Other Phenotypes
Allele
abnormal neuroanatomy
Phenotype manifest in
Allele
symmetrical commissure
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (34)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\DSCAM
9 of 15
Yes
No
3  
Hsap\DSCAML1
9 of 15
Yes
No
2  
Hsap\CEACAM1
1 of 15
No
Yes
Hsap\CEACAM16
1 of 15
No
Yes
Hsap\CNTN2
1 of 15
No
No
0  
Hsap\CNTN4
1 of 15
No
No
Hsap\CNTN6
1 of 15
No
No
Hsap\HSPG2
1 of 15
No
No
Hsap\IGLON5
1 of 15
No
No
Hsap\IGSF9B
1 of 15
No
No
Hsap\IGSF9
1 of 15
No
No
2  
Hsap\KIRREL1
1 of 15
No
No
Hsap\KIRREL2
1 of 15
No
No
Hsap\KIRREL3
1 of 15
No
No
Hsap\LIFR
1 of 15
No
Yes
Hsap\LRIT1
1 of 15
No
Yes
Hsap\LRIT3
1 of 15
No
Yes
Hsap\LSAMP
1 of 15
No
No
Hsap\MDGA1
1 of 15
No
Yes
Hsap\MYPN
1 of 15
No
No
Hsap\NCAM1
1 of 15
No
No
4  
Hsap\NCAM2
1 of 15
No
No
Hsap\NEGR1
1 of 15
No
No
1  
Hsap\NTM
1 of 15
No
No
Hsap\OPCML
1 of 15
No
No
Hsap\PALLD
1 of 15
No
No
Hsap\PAPLN
1 of 15
No
No
Hsap\PSG1
1 of 15
No
Yes
Hsap\PSG4
1 of 15
No
Yes
Hsap\PSG9
1 of 15
No
Yes
Hsap\PTPRQ
1 of 15
No
No
Hsap\SDK1
1 of 15
No
No
Hsap\SDK2
1 of 15
No
No
1  
Hsap\USH2A
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (43)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Dscam
9 of 15
Yes
No
1  
Mmus\Dscaml1
8 of 15
No
No
Mmus\Ceacam1
1 of 15
No
Yes
Mmus\Ceacam2
1 of 15
No
Yes
Mmus\Ceacam5
1 of 15
No
Yes
Mmus\Ceacam16
1 of 15
No
Yes
Mmus\Cntn5
1 of 15
No
No
Mmus\Cntn6
1 of 15
No
No
Mmus\Gm5155
1 of 15
No
Yes
Mmus\Iglon5
1 of 15
No
No
Mmus\Igsf9b
1 of 15
No
No
Mmus\Igsf9
1 of 15
No
No
Mmus\Kirrel2
1 of 15
No
No
1  
Mmus\Kirrel3
1 of 15
No
No
1  
Mmus\Kirrel
1 of 15
No
No
1  
Mmus\Lifr
1 of 15
No
Yes
Mmus\Lrit1
1 of 15
No
Yes
Mmus\Lrit3
1 of 15
No
Yes
Mmus\Lsamp
1 of 15
No
No
Mmus\Mypn
1 of 15
No
No
Mmus\Ncam1
1 of 15
No
No
Mmus\Ncam2
1 of 15
No
No
Mmus\Negr1
1 of 15
No
No
Mmus\Nrcam
1 of 15
No
No
Mmus\Ntm
1 of 15
No
No
Mmus\Opcml
1 of 15
No
No
Mmus\Papln
1 of 15
No
No
Mmus\Psg16
1 of 15
No
Yes
Mmus\Psg17
1 of 15
No
Yes
Mmus\Psg18
1 of 15
No
Yes
Mmus\Psg19
1 of 15
No
Yes
Mmus\Psg21
1 of 15
No
Yes
Mmus\Psg22
1 of 15
No
Yes
Mmus\Psg23
1 of 15
No
Yes
Mmus\Psg25
1 of 15
No
Yes
Mmus\Psg26
1 of 15
No
Yes
Mmus\Psg27
1 of 15
No
Yes
Mmus\Psg28
1 of 15
No
Yes
Mmus\Psg29
1 of 15
No
Yes
Mmus\Ptprq
1 of 15
No
No
Mmus\Sdk1
1 of 15
No
No
Mmus\Sdk2
1 of 15
No
No
Mmus\Vstm2l
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (26)
Rnor\Dscaml1
9 of 13
Yes
No
Rnor\Dscam
9 of 13
Yes
No
Rnor\Ceacam1
1 of 13
No
Yes
Rnor\Ceacam3
1 of 13
No
Yes
Rnor\Ceacam16
1 of 13
No
Yes
Rnor\Cntn4
1 of 13
No
No
Rnor\Iglon5
1 of 13
No
No
Rnor\Igsf9b
1 of 13
No
No
Rnor\Igsf9
1 of 13
No
No
Rnor\Kirrel1
1 of 13
No
No
Rnor\Kirrel2
1 of 13
No
No
Rnor\Kirrel3
1 of 13
No
No
Rnor\LOC100360205
1 of 13
No
Yes
Rnor\LOC102557319
1 of 13
No
Yes
Rnor\Lrit1
1 of 13
No
No
Rnor\Lsamp
1 of 13
No
No
Rnor\Ncam1
1 of 13
No
No
Rnor\Ncam2
1 of 13
No
No
Rnor\Nrcam
1 of 13
No
No
2  
Rnor\Ntm
1 of 13
No
No
Rnor\Opcml
1 of 13
No
No
Rnor\Psg16
1 of 13
No
Yes
Rnor\Psg19
1 of 13
No
Yes
Rnor\Psg29
1 of 13
No
Yes
Rnor\Psgb1
1 of 13
No
Yes
Rnor\Sdk2
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (12)
Xtro\dscaml1
5 of 12
Yes
No
Xtro\dscam
3 of 12
No
No
Xtro\iglon5
1 of 12
No
No
Xtro\igsf9b
1 of 12
No
No
Xtro\igsf9
1 of 12
No
No
Xtro\kirrel2
1 of 12
No
No
Xtro\lrit3
1 of 12
No
Yes
Xtro\lsamp
1 of 12
No
No
Xtro\ncam2
1 of 12
No
No
Xtro\negr1
1 of 12
No
No
Xtro\ntm
1 of 12
No
No
Xtro\papln
1 of 12
No
No
Danio rerio (Zebrafish) (35)
Drer\dscama
9 of 15
Yes
No
Drer\dscamb
9 of 15
Yes
No
Drer\dscaml1
6 of 15
No
No
Drer\robo4
2 of 15
No
No
Drer\cntn3a.1
1 of 15
No
No
Drer\cntn3a.2
1 of 15
No
No
Drer\igsf9a
1 of 15
No
No
Drer\igsf9ba
1 of 15
No
No
Drer\igsf9bb
1 of 15
No
No
Drer\igsf9b
1 of 15
No
No
Drer\itgb4
1 of 15
No
No
Drer\kirrel1b
1 of 15
No
No
Drer\kirrel3a
1 of 15
No
No
Drer\kirrel3b
1 of 15
No
No
Drer\kirrel3l
1 of 15
No
No
Drer\lrit1a
1 of 15
No
Yes
Drer\lrit1b
1 of 15
No
Yes
Drer\lrit3a
1 of 15
No
Yes
Drer\lrit3b
1 of 15
No
No
Drer\ncam1a
1 of 15
No
No
Drer\ncam1b
1 of 15
No
No
Drer\negr1
1 of 15
No
No
Drer\ntm
1 of 15
No
No
Drer\opcml
1 of 15
No
No
Drer\paplna
1 of 15
No
No
Drer\ptprq
1 of 15
No
No
Drer\sdk1a
1 of 15
No
No
Drer\sdk1b
1 of 15
No
No
Drer\sdk2a
1 of 15
No
No
Drer\sdk2b
1 of 15
No
No
Drer\si:ch1073-459j12.1
1 of 15
No
No
Drer\si:dkeyp-75h12.2
1 of 15
No
No
Drer\ush2a
1 of 15
No
Yes
Drer\vstm2l
1 of 15
No
Yes
Drer\zgc:110372
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (20)
Cele\rig-3
2 of 15
Yes
Yes
Cele\zig-2
2 of 15
Yes
No
Cele\zig-3
2 of 15
Yes
No
Cele\zig-4
2 of 15
Yes
No
Cele\C27B7.7
1 of 15
No
Yes
Cele\C53A5.13
1 of 15
No
Yes
Cele\him-4
1 of 15
No
No
Cele\igcm-2
1 of 15
No
No
Cele\lad-2
1 of 15
No
No
Cele\let-805
1 of 15
No
Yes
Cele\ncam-1
1 of 15
No
No
Cele\rig-4
1 of 15
No
No
Cele\rig-5
1 of 15
No
No
Cele\rig-6
1 of 15
No
No
Cele\syg-1
1 of 15
No
No
Cele\wrk-1
1 of 15
No
No
Cele\zig-6
1 of 15
No
Yes
Cele\zig-7
1 of 15
No
Yes
Cele\zig-8
1 of 15
No
No
Cele\zig-11
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190081 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00008298
Drosophila simulans
Dsim\GD20229
Drosophila sechellia
Dsec\GM15359
Drosophila erecta
Dere\GG16771
Drosophila yakuba
Dyak\GE25266
Drosophila yakuba
Dyak\GE29207
Drosophila ananassae
Dana\GF18608
Drosophila pseudoobscura pseudoobscura
Dpse\GA16078
Drosophila persimilis
Dper\GL23930
Drosophila willistoni
Dwil\GK11449
Drosophila virilis
Dvir\GJ22820
Drosophila mojavensis
Dmoj\GI22819
Drosophila grimshawi
Dgri\GH17490
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915004O )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17023832
Musca domestica
House fly
Mdoa\17019752
Glossina morsitans
Tsetse fly
Gmor\GMOY005407
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_07343
Mayetiola destructor
Hessian fly
Mdes\Mdes001652
Mayetiola destructor
Hessian fly
Mdes\Mdes001651
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL011284
Anopheles darlingi
American malaria mosquito
Adar\ADAC001373
Anopheles gambiae
Malaria mosquito
Agam\AGAP005219
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W003W )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA005747
Danaus plexippus
Monarch butterfly
Dple\DPOGS202957-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL014876
Heliconius melpomene
Postman butterfly
Hmel\HMEL002841
Apis florea
Little honeybee
Aflo\2336412036
Apis mellifera
Western honey bee
Amel\GB53701
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP17291
Bombus terrestris
Buff-tailed bumblebee
Bter\15210398
Linepithema humile
Argentine ant
Lhum\LH12315
Linepithema humile
Argentine ant
Lhum\LH12316
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00166b
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012653
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012654
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02442
Tribolium castaneum
Red flour beetle
Tcas\TC031564
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_17738
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X002X )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR010628
Strigamia maritima
European centipede
Smar\SMAR000414
Strigamia maritima
European centipede
Smar\SMAR005060
Strigamia maritima
European centipede
Smar\SMAR005038
Strigamia maritima
European centipede
Smar\SMAR010347
Strigamia maritima
European centipede
Smar\SMAR010787
Strigamia maritima
European centipede
Smar\SMAR014698
Strigamia maritima
European centipede
Smar\SMAR009342
Strigamia maritima
European centipede
Smar\SMAR004329
Strigamia maritima
European centipede
Smar\SMAR000919
Strigamia maritima
European centipede
Smar\SMAR011561
Strigamia maritima
European centipede
Smar\SMAR005057
Strigamia maritima
European centipede
Smar\SMAR005788
Strigamia maritima
European centipede
Smar\SMAR010689
Strigamia maritima
European centipede
Smar\SMAR011672
Strigamia maritima
European centipede
Smar\SMAR013782
Strigamia maritima
European centipede
Smar\SMAR008780
Strigamia maritima
European centipede
Smar\SMAR009392
Strigamia maritima
European centipede
Smar\SMAR010961
Strigamia maritima
European centipede
Smar\SMAR013914
Strigamia maritima
European centipede
Smar\SMAR011548
Strigamia maritima
European centipede
Smar\SMAR007303
Strigamia maritima
European centipede
Smar\SMAR011182
Strigamia maritima
European centipede
Smar\SMAR014353
Strigamia maritima
European centipede
Smar\SMAR010692
Strigamia maritima
European centipede
Smar\SMAR012325
Strigamia maritima
European centipede
Smar\SMAR005787
Strigamia maritima
European centipede
Smar\SMAR013694
Strigamia maritima
European centipede
Smar\SMAR014212
Strigamia maritima
European centipede
Smar\SMAR004313
Strigamia maritima
European centipede
Smar\SMAR010788
Strigamia maritima
European centipede
Smar\SMAR014338
Strigamia maritima
European centipede
Smar\SMAR011726
Strigamia maritima
European centipede
Smar\SMAR010346
Strigamia maritima
European centipede
Smar\SMAR004310
Strigamia maritima
European centipede
Smar\SMAR001994
Strigamia maritima
European centipede
Smar\SMAR010994
Strigamia maritima
European centipede
Smar\SMAR009858
Strigamia maritima
European centipede
Smar\SMAR005058
Strigamia maritima
European centipede
Smar\SMAR000686
Strigamia maritima
European centipede
Smar\SMAR011562
Strigamia maritima
European centipede
Smar\SMAR011320
Strigamia maritima
European centipede
Smar\SMAR011319
Strigamia maritima
European centipede
Smar\SMAR015611
Strigamia maritima
European centipede
Smar\SMAR013749
Strigamia maritima
European centipede
Smar\SMAR011671
Strigamia maritima
European centipede
Smar\SMAR009857
Strigamia maritima
European centipede
Smar\SMAR009349
Strigamia maritima
European centipede
Smar\SMAR013837
Strigamia maritima
European centipede
Smar\SMAR009501
Strigamia maritima
European centipede
Smar\SMAR011727
Strigamia maritima
European centipede
Smar\SMAR009834
Strigamia maritima
European centipede
Smar\SMAR003721
Strigamia maritima
European centipede
Smar\SMAR010629
Ixodes scapularis
Black-legged tick
Isca\ISCW022826
Ixodes scapularis
Black-legged tick
Isca\ISCW017602
Ixodes scapularis
Black-legged tick
Isca\ISCW017597
Ixodes scapularis
Black-legged tick
Isca\ISCW023871
Ixodes scapularis
Black-legged tick
Isca\ISCW001673
Ixodes scapularis
Black-legged tick
Isca\ISCW016099
Ixodes scapularis
Black-legged tick
Isca\ISCW017420
Ixodes scapularis
Black-legged tick
Isca\ISCW001245
Ixodes scapularis
Black-legged tick
Isca\ISCW016844
Ixodes scapularis
Black-legged tick
Isca\ISCW022093
Ixodes scapularis
Black-legged tick
Isca\ISCW019537
Ixodes scapularis
Black-legged tick
Isca\ISCW017407
Ixodes scapularis
Black-legged tick
Isca\ISCW023928
Ixodes scapularis
Black-legged tick
Isca\ISCW020407
Ixodes scapularis
Black-legged tick
Isca\ISCW022837
Ixodes scapularis
Black-legged tick
Isca\ISCW017409
Ixodes scapularis
Black-legged tick
Isca\ISCW010083
Ixodes scapularis
Black-legged tick
Isca\ISCW016847
Ixodes scapularis
Black-legged tick
Isca\ISCW022096
Ixodes scapularis
Black-legged tick
Isca\ISCW022820
Ixodes scapularis
Black-legged tick
Isca\ISCW022831
Ixodes scapularis
Black-legged tick
Isca\ISCW022819
Stegodyphus mimosarum
African social velvet spider
Smim\KFM82055.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM75330.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM71651.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM72780.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM82606.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM64485.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM82057.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM78901.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM78654.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM75331.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM70029.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM81635.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM78043.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM72392.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM68992.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM74747.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM81636.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM79756.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur19g02050
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g02890
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g01100
Tetranychus urticae
Two-spotted spider mite
Turt\tetur19g01590
Tetranychus urticae
Two-spotted spider mite
Turt\tetur11g03400
Tetranychus urticae
Two-spotted spider mite
Turt\tetur07g02520
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g02800
Tetranychus urticae
Two-spotted spider mite
Turt\tetur07g00600
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g02880
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g02780
Tetranychus urticae
Two-spotted spider mite
Turt\tetur17g02480
Tetranychus urticae
Two-spotted spider mite
Turt\tetur16g02990
Tetranychus urticae
Two-spotted spider mite
Turt\tetur21g02250
Tetranychus urticae
Two-spotted spider mite
Turt\tetur09g01130
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g01050
Tetranychus urticae
Two-spotted spider mite
Turt\tetur10g00850
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_127336
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_43826
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_48415
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_262741
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_331991
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_44367
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G005W )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Mlckb
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Mlck
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-DscamL
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-DscamL_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Mlck1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Mlck_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Igf_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Mlcka
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Igcam/Igcam/Igcam
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-TtnL_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-MlckL
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000022039
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000012471
Ciona intestinalis
Vase tunicate
Cint\LOC100179969
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000000824
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000007314
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000006273
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000016138
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000004334
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000011708
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000012845
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (60)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Dscam1
5 of 10
Dscam4
5 of 10
Dscam2
4 of 10
Fas2
3 of 10
tutl
3 of 10
bdl
2 of 10
Cont
2 of 10
Ama
1 of 10
babos
1 of 10
boi
1 of 10
Bsg
1 of 10
CG7166
1 of 10
CG13506
1 of 10
CG33543
1 of 10
CG34353
1 of 10
CG44153
1 of 10
DIP-α
1 of 10
DIP-β
1 of 10
DIP-δ
1 of 10
DIP-ε
1 of 10
DIP-η
1 of 10
DIP-γ
1 of 10
DIP-ι
1 of 10
DIP-κ
1 of 10
DIP-θ
1 of 10
DIP-ζ
1 of 10
dpr1
1 of 10
dpr2
1 of 10
dpr3
1 of 10
dpr4
1 of 10
dpr5
1 of 10
dpr6
1 of 10
dpr7
1 of 10
dpr8
1 of 10
dpr9
1 of 10
dpr10
1 of 10
dpr11
1 of 10
dpr12
1 of 10
dpr13
1 of 10
dpr14
1 of 10
dpr15
1 of 10
dpr16
1 of 10
dpr17
1 of 10
dpr18
1 of 10
dpr19
1 of 10
dpr20
1 of 10
dpr21
1 of 10
fipi
1 of 10
ihog
1 of 10
ImpL2
1 of 10
kirre
1 of 10
klg
1 of 10
Lac
1 of 10
plum
1 of 10
robo2
1 of 10
robo3
1 of 10
rst
1 of 10
sdk
1 of 10
Strn-Mlck
1 of 10
wrapper
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    DSCAM; DS cell adhesion molecule
    9 of 15
    602523
         
        DSCAML1; DS cell adhesion molecule like 1
        9 of 15
        611782
             
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Show neighbor-neighbor interactions:
            Select Layout:
            Legend:
            Protein
            RNA
            Selected Interactor(s)
            Interactions Browser
            View in Interactions Browser
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            Dscam3
            enzyme linked immunosorbent assay, anti tag coimmunoprecipitation, anti tag western blot
            (Ozkan et al., 2013, Millard et al., 2007)
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            fra
            enhanceable
            Dscam3|Dscam1
            (Andrews et al., 2008)
            External Data
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            External Data
            Linkouts
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3R
            Recombination map
            3-61
            Cytogenetic map
            90B1-90B1
            Sequence location
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            90B1-90B1
            Limits computationally determined from genome sequence between P{EP}CG5208EP562&P{EP}DadEP3196 and P{PZ}l(3)0788207882
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            Experimentally Determined Recombination Data
            Location

            3-61

            (FlyBase, 2016)

            3-59.6

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (10)
            Genomic Clones (56)
            cDNA Clones (16)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of
              Source for database merge of

              Source for merge of: Dscam3 CG31190

              (Andrews et al., 2008)

              Source for merge of: CG8106 CG12536

              (FlyBase Genome Annotators, 2002-2003)
              Additional comments

              FlyBase curator comment: Correspondence with author Andrews revealed that 'Dscam3' = 'CG31190'.

              (Andrews and Kidd, 2008)

              Annotations CG8106 and CG12536 merged as CG31190 in release 3 of the genome annotation.

              (FlyBase Genome Annotators, 2002-2003)
              Other Comments
              Origin and Etymology
              Discoverer
              Etymology
              Identification
              External Crossreferences and Linkouts ( 50 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              Flygut - An atlas of the Drosophila adult midgut
              FlyMine - An integrated database for Drosophila genomics
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              modMine - A data warehouse for the modENCODE project
              Linkouts
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              Synonyms and Secondary IDs (8)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              References (51)