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Gene Dmel\Sytα

General Information
Symbol	Dmel\Sytα	Species	D. melanogaster
Name	Synaptotagmin α	Annotation symbol	CG5559
Feature type	protein_coding_gene	FlyBase ID	FBgn0261089
Gene Model Status	Current	Stock availability	10 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	36D-36D	Sequence location	2L:17,592,260..17,604,387 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Synaptotagmin α is referred to in FlyBase by the symbol Dmel\Sytα (CG5559, FBgn0261089). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: calcium-dependent phospholipid binding. Based on sequence similarity, it is predicted to be involved in the biological process: neurotransmitter secretion; vesicle-mediated transport. 10 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: C2 calcium-dependent membrane targeting; C2 calcium/lipid-binding domain, CaLB; C2 domain; C2 membrane targeting protein. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of no expression detected. Peak expression observed within 18-24 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult brain. Comments on Affy2 ProbeSet: ProbeSet 1636968_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of Sytalpha. Gene sequence location is 2L:17592260..17604387.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 36D-36D   Left limit from (method unavailable) (FBrf0127207) Right limit from (method unavailable) (FBrf0127207)
Experimentally Determined Cytological Location
Cytogenetic map Notes References 36D-36D   Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.   (Lloyd et al., 2000)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Sytα for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Sytα-RA FBtr0080987  NM_136009   2037   494 Sytα-RB FBtr0303254  NM_001201903   1931   504 Sytα-RC FBtr0303255  NM_001201904   2189   494 Sytα-RD FBtr0340251     2936   494
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Sytα-PA   FBpp0080540   54.4   494   8.29     NP_609853   AAG22438 Sytα-PB   FBpp0292346   55.4   504   8.00     NP_001188832   ADV37081 Sytα-PC   FBpp0292347   54.4   494   8.29     NP_001188833   ADV37082 Sytα-PD   FBpp0309223   54.4   494   8.29
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • C2 membrane targeting protein (IPR018029) C2 calcium/lipid-binding domain, CaLB (IPR008973) C2 calcium-dependent membrane targeting (IPR000008) C2 domain (IPR020477)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA698066   AE014134 AAG22438   AE014134 ADV37081   AE014134 ADV37082   BH809416   BT060450   CO281481   CO321175   CO340542   CZ479718   CZ482595   EC084872   EC204518   EC214325   EC260341   EW713000   EY198906
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9I7M6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult brain. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    25.975 Larval Midgut    11.3 Larval Hindgut    3.6 Larval Malpighian Tubules    3.4 Larval Fat Body    7.5 Larval Salivary Gland    6.6 Larval Trachea    1.4 Larval Carcass    3.825 Adult Head    68 Adult Eye    13.55 Adult Brain    245 Adult Thoracic-Abdominal Ganglion    57.2 Adult Crop    7.4 Adult Midgut    21.7 Adult Hindgut    6.9 Adult Malpighian Tubules    4.9 Adult Fat Body    10.9 Adult Salivary Gland    13 Adult Heart    3.3 Adult VirginFemale Spermatheca    6.9 Adult InseminatedFemale Spermatheca    5.3 Adult Ovary    2.6 Adult Testis    12.6 Adult Male Accessory Gland    6.4 Adult Carcass    8.1 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    25.975 Larval Midgut    11.3 Larval Hindgut    3.6 Larval Malpighian Tubules    3.4 Larval Fat Body    7.5 Larval Salivary Gland    6.6 Larval Trachea    1.4 Larval Carcass    3.825 Adult Head    68 Adult Eye    13.55 Adult Brain    245 Adult Thoracic-Abdominal Ganglion    57.2 Adult Crop    7.4 Adult Midgut    21.7 Adult Hindgut    6.9 Adult Malpighian Tubules    4.9 Adult Fat Body    10.9 Adult Salivary Gland    13 Adult Heart    3.3 Adult VirginFemale Spermatheca    6.9 Adult InseminatedFemale Spermatheca    5.3 Adult Ovary    2.6 Adult Testis    12.6 Adult Male Accessory Gland    6.4 Adult Carcass    8.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    25.975 Larval Midgut    11.3 Larval Hindgut    3.6 Larval Malpighian Tubules    3.4 Larval Fat Body    7.5 Larval Salivary Gland    6.6 Larval Trachea    1.4 Larval Carcass    3.825 Adult Head    68 Adult Eye    13.55 Adult Brain    245 Adult Thoracic-Abdominal Ganglion    57.2 Adult Crop    7.4 Adult Midgut    21.7 Adult Hindgut    6.9 Adult Malpighian Tubules    4.9 Adult Fat Body    10.9 Adult Salivary Gland    13 Adult Heart    3.3 Adult VirginFemale Spermatheca    6.9 Adult InseminatedFemale Spermatheca    5.3 Adult Ovary    2.6 Adult Testis    12.6 Adult Male Accessory Gland    6.4 Adult Carcass    8.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    25.975 Larval Midgut    11.3 Larval Hindgut    3.6 Larval Malpighian Tubules    3.4 Larval Fat Body    7.5 Larval Salivary Gland    6.6 Larval Trachea    1.4 Larval Carcass    3.825 Adult Head    68 Adult Eye    13.55 Adult Brain    245 Adult Thoracic-Abdominal Ganglion    57.2 Adult Crop    7.4 Adult Midgut    21.7 Adult Hindgut    6.9 Adult Malpighian Tubules    4.9 Adult Fat Body    10.9 Adult Salivary Gland    13 Adult Heart    3.3 Adult VirginFemale Spermatheca    6.9 Adult InseminatedFemale Spermatheca    5.3 Adult Ovary    2.6 Adult Testis    12.6 Adult Male Accessory Gland    6.4 Adult Carcass    8.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    25.975 Larval Midgut    11.3 Larval Hindgut    3.6 Larval Malpighian Tubules    3.4 Larval Fat Body    7.5 Larval Salivary Gland    6.6 Larval Trachea    1.4 Larval Carcass    3.825 Adult Head    68 Adult Eye    13.55 Adult Brain    245 Adult Thoracic-Abdominal Ganglion    57.2 Adult Crop    7.4 Adult Midgut    21.7 Adult Hindgut    6.9 Adult Malpighian Tubules    4.9 Adult Fat Body    10.9 Adult Salivary Gland    13 Adult Heart    3.3 Adult VirginFemale Spermatheca    6.9 Adult InseminatedFemale Spermatheca    5.3 Adult Ovary    2.6 Adult Testis    12.6 Adult Male Accessory Gland    6.4 Adult Carcass    8.1 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    25.975 Larval Midgut    11.3 Larval Hindgut    3.6 Larval Malpighian Tubules    3.4 Larval Fat Body    7.5 Larval Salivary Gland    6.6 Larval Trachea    1.4 Larval Carcass    3.825 Adult Head    68 Adult Eye    13.55 Adult Brain    245 Adult Thoracic-Abdominal Ganglion    57.2 Adult Crop    7.4 Adult Midgut    21.7 Adult Hindgut    6.9 Adult Malpighian Tubules    4.9 Adult Fat Body    10.9 Adult Salivary Gland    13 Adult Heart    3.3 Adult VirginFemale Spermatheca    6.9 Adult InseminatedFemale Spermatheca    5.3 Adult Ovary    2.6 Adult Testis    12.6 Adult Male Accessory Gland    6.4 Adult Carcass    8.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    25.975 Larval Midgut    11.3 Larval Hindgut    3.6 Larval Malpighian Tubules    3.4 Larval Fat Body    7.5 Larval Salivary Gland    6.6 Larval Trachea    1.4 Larval Carcass    3.825 Adult Head    68 Adult Eye    13.55 Adult Brain    245 Adult Thoracic-Abdominal Ganglion    57.2 Adult Crop    7.4 Adult Midgut    21.7 Adult Hindgut    6.9 Adult Malpighian Tubules    4.9 Adult Fat Body    10.9 Adult Salivary Gland    13 Adult Heart    3.3 Adult VirginFemale Spermatheca    6.9 Adult InseminatedFemale Spermatheca    5.3 Adult Ovary    2.6 Adult Testis    12.6 Adult Male Accessory Gland    6.4 Adult Carcass    8.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    25.975 Larval Midgut    11.3 Larval Hindgut    3.6 Larval Malpighian Tubules    3.4 Larval Fat Body    7.5 Larval Salivary Gland    6.6 Larval Trachea    1.4 Larval Carcass    3.825 Adult Head    68 Adult Eye    13.55 Adult Brain    245 Adult Thoracic-Abdominal Ganglion    57.2 Adult Crop    7.4 Adult Midgut    21.7 Adult Hindgut    6.9 Adult Malpighian Tubules    4.9 Adult Fat Body    10.9 Adult Salivary Gland    13 Adult Heart    3.3 Adult VirginFemale Spermatheca    6.9 Adult InseminatedFemale Spermatheca    5.3 Adult Ovary    2.6 Adult Testis    12.6 Adult Male Accessory Gland    6.4 Adult Carcass    8.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    68   NA  Eye    no informative data   NA  Brain    245   25.975  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    57.2   NA  Crop    7.4   no informative data  Midgut    21.7   3.6  Hindgut    6.9   3.4  Malpighian Tubules    4.9   7.5  Fat Body    10.9   6.6  Salivary Gland    no informative data   NA  Heart    3.3   1.4  Trachea    NA   NA  VirginFemale Spermatheca    6.9   NA  InseminatedFemale Spermatheca    5.3   NA  Ovary    2.6   NA  Testis    12.6   NA  Male Accessory Gland    6.4   3.825  Carcass    8.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    5 central nervous system, pupae P8    2 head, virgin 1-day female    13 head, virgin 4-day female    11 head, virgin 20-day female    11 head, mated 1-day female    9 head, mated 4-day female    11 head, mated 20-day female    9 head, mated 1-day male    18 head, mated 4-day male    19 head, mated 20-day male    18 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    5 central nervous system, pupae P8    2 head, virgin 1-day female    13 head, virgin 4-day female    11 head, virgin 20-day female    11 head, mated 1-day female    9 head, mated 4-day female    11 head, mated 20-day female    9 head, mated 1-day male    18 head, mated 4-day male    19 head, mated 20-day male    18 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    5 central nervous system, pupae P8    2 head, virgin 1-day female    13 head, virgin 4-day female    11 head, virgin 20-day female    11 head, mated 1-day female    9 head, mated 4-day female    11 head, mated 20-day female    9 head, mated 1-day male    18 head, mated 4-day male    19 head, mated 20-day male    18 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    5 central nervous system, pupae P8    2 head, virgin 1-day female    13 head, virgin 4-day female    11 head, virgin 20-day female    11 head, mated 1-day female    9 head, mated 4-day female    11 head, mated 20-day female    9 head, mated 1-day male    18 head, mated 4-day male    19 head, mated 20-day male    18 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    5 central nervous system, pupae P8    2 head, virgin 1-day female    13 head, virgin 4-day female    11 head, virgin 20-day female    11 head, mated 1-day female    9 head, mated 4-day female    11 head, mated 20-day female    9 head, mated 1-day male    18 head, mated 4-day male    19 head, mated 20-day male    18 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    5 central nervous system, pupae P8    2 head, virgin 1-day female    13 head, virgin 4-day female    11 head, virgin 20-day female    11 head, mated 1-day female    9 head, mated 4-day female    11 head, mated 20-day female    9 head, mated 1-day male    18 head, mated 4-day male    19 head, mated 20-day male    18 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    5 central nervous system, pupae P8    2 head, virgin 1-day female    13 head, virgin 4-day female    11 head, virgin 20-day female    11 head, mated 1-day female    9 head, mated 4-day female    11 head, mated 20-day female    9 head, mated 1-day male    18 head, mated 4-day male    19 head, mated 20-day male    18 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    5 central nervous system, pupae P8    2 head, virgin 1-day female    13 head, virgin 4-day female    11 head, virgin 20-day female    11 head, mated 1-day female    9 head, mated 4-day female    11 head, mated 20-day female    9 head, mated 1-day male    18 head, mated 4-day male    19 head, mated 20-day male    18 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of no expression detected. Peak expression observed within 18-24 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    3 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    3 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    3 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    3 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    1 adult female 30day    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    3 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    3 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    3 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    3 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    669 embryonic Kc167    14 embryonic S1    59 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2  (669) embryonic Kc167    14 embryonic S1  (59) embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2  (669) embryonic Kc167    14 embryonic S1    59 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    669 embryonic Kc167    14 embryonic S1    59 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    669 embryonic Kc167    14 embryonic S1    59 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2  (669) embryonic Kc167    14 embryonic S1  (59) embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2  (669) embryonic Kc167    14 embryonic S1    59 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    669 embryonic Kc167    14 embryonic S1    59 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_13
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0261089
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 SytαGD1754 Phenotype manifest in Allele
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of Sytα Class Mutagen Stocks Known lesion Sytαe01880 1 -- Sytαe01903 piggyBac transposase 1 -- Sytαf00110 piggyBac transposase 1 -- SytαKG02182 P-element activity 1 -- SytαMI02881 1 -- SytαMI03607 1 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Sytα Class Mutagen Stocks Known lesion SytαGD1754 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes SytαJF02448 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SytαKK106350 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SytαNIG.5559R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7069 (Ryder, 2004.4.26) Df(2L)Exel9044 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}SytαMI02881 NA Mi{MIC}SytαMI03607 NA P{SUPor-P}SytαKG02182 NA PBac{RB}Sytαe01880 NA PBac{RB}Sytαe01903 NA PBac{WH}Sytαf00110 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
calcium-dependent phospholipid binding inferred from sequence or structural similarity with UniProtKB:P29101 (FlyBase, 1992-) non-traceable author statement (Lloyd et al., 2000)
Biological Process
CV term Evidence References
neurotransmitter secretion inferred from sequence or structural similarity with UniProtKB:P29101 (FlyBase, 1992-) non-traceable author statement (Lloyd et al., 2000) vesicle-mediated transport inferred from sequence or structural similarity with UniProtKB:P29101 (FlyBase, 1992-) non-traceable author statement (Lloyd et al., 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene (Adolfsen et al., 2004, ) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Sytα allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0261089 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35068
Orthologs
OrthoDB Orthologs (24) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6960BH Dipteran inclusive ortholog search EOG6RJG8Z Insect inclusive ortholog search EOG6GXDH1 Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search EOG6SR8Q0
Orthologs in Drosophila Species (EOG6960BH)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Sytα     Drosophila simulans   Dsim\GD12033 Y   Drosophila sechellia   Dsec\GM17249 Y   Drosophila erecta   Dere\GG21095 Y   Drosophila yakuba   Dyak\GE12800 Y   Drosophila ananassae   Dana\GF14804 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA18970 Y   Drosophila persimilis   Dper\GL16026 Y   Drosophila willistoni   Dwil\GK18165 Y   Drosophila virilis   Dvir\GJ17702 Y   Drosophila mojavensis   Dmoj\GI17929 Y   Drosophila grimshawi   Dgri\GH11627 Y
Orthologs in non-Drosophila Dipterans (EOG6RJG8Z)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL001167   Anopheles gambiae Malaria mosquito  Agam\AGAP008650   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ017731
Orthologs in non-Dipteran Insects (EOG6GXDH1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007379   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14655   Atta cephalotes Leafcutter ant  Acep\ACEP24054   Camponotus floridanus Florida carpenter ant  Cflo\CFLO14970   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22336   Linepithema humile Argentine ant  Lhum\LH19721   Pogonomyrmex barbatus Red harvester ant  Pbar\PB20931   Solenopsis invicta Red fire ant  Sinv\SINV23327
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (EOG6SR8Q0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_019995gn
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD12033 Drosophila sechellia Dsec\GM17249 Drosophila erecta Dere\GG21095 Drosophila yakuba Dyak\GE12800 Drosophila ananassae Dana\GF14804 Drosophila pseudoobscura pseudoobscura Dpse\GA18970 Drosophila persimilis Dper\GL16026 Drosophila willistoni Dwil\GK18165 Drosophila virilis Dvir\GJ17702 Drosophila mojavensis Dmoj\GI17929 Drosophila grimshawi Dgri\GH11627
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	29308 y1 v1; P{TRiP.JF02448}attP2 37063 y1 w*; Mi{MIC}SytαMI03607 35907 y1 w*; Mi{MIC}SytαMI02881/SM6a 13931 y1 w67c23; P{SUPor-P}SytαKG02182
Harvard	- PBac{RB}Sytαe01880 - PBac{RB}Sytαe01903 - PBac{WH}Sytαf00110
VDRC	v100957 P{KK106350}VIE-260B v9303 w1118; P{GD1754}v9303/TM3 v9305 w1118; P{GD1754}v9305/CyO
Genomic Clones ( 1 )
	BACR48K02 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 9 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones	MIP05618
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	HL03724
Other clones	42469 119379 174936 214439.36 EK157257 EK290439 EP10846
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0261089 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35068
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: sytα CG5559 (Adolfsen et al., 2004) Source for merge of: Sytα Syt3 (Lloyd et al., 2000)
Additional comments	FlyBase Curator comment: Table 1 of FBrf0127207 mentions a Synaptotagmin gene called 'SYT3' at cytological location 36D. 'SYT3' is unknown to FlyBase, but it is assumed to equate to 'Synaptotagmin alpha' (CG5559) because it is the only one of the seven Synaptotagmin genes (see FBrf0179104) that maps to 36D. (Lloyd et al., 2000)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136009 NM_001201903 NM_001201904 RefSeq (Proteins) • NP_609853 NP_001188832 NP_001188833 DDBJ / EMBL / GenBank • AAG22438 ADV37081 ADV37082 BH809416 CZ479718 CZ482595 Entrez Gene - A searchable database of RefSeq genes. • 35068 UniProtKB/TrEMBL • Q9I7M6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • C2 membrane targeting protein (IPR018029) C2 calcium/lipid-binding domain, CaLB (IPR008973) C2 calcium-dependent membrane targeting (IPR000008) C2 domain (IPR020477)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0261089 DRSC - Results from RNAi screens. • FBgn0261089 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0261089 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0261089 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35068 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35068 modMine - Data generated by the modENCODE project. • FBgn0261089
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG5559 (Keleman et al., 2009.8.5, Perkins et al., 2009, Japanese National Institute of Genetics, 2012.5.21) dsytα (Adolfsen et al., 2004) SYT3 (Lloyd et al., 2000) Syt3   Sytalpha (Craxton, 2010) sytα   Syt α (Adolfsen et al., 2004) Sytα   unnamed (Craxton, 2001)
Name Synonym	CG5559   Synaptotagmin α   Syt3   sytα
Secondary FlyBase IDs
	FBgn0032653 FBgn0042690 FBgn0085002 FBgn0261087
References ( 18 )
Research paper	Craxton, 2010, BMC Genomics 11: 37 A manual collection of Syt, Esyt, Rph3a, Rph3al, Doc2, and Dblc2 genes from 46 metazoan genomes - an open access resource for neuroscience and evolutionary biology. [FBrf0210023] Adolfsen et al., 2004, J. Cell Biol. 166(2): 249--260 Synaptotagmins are trafficked to distinct subcellular domains including the postsynaptic compartment. [FBrf0179104] Solano et al., 2003, Development 130(7): 1243--1254 Genome-wide identification of in vivo Drosophila Engrailed-binding DNA fragments and related target genes. [FBrf0155700] Craxton, 2001, Genomics 77(1/2): 43--49 Genomic analysis of synaptotagmin genes. [FBrf0138425] Lloyd et al., 2000, Neuron 26(1): 45--50 A genome-wide search for synaptic vesicle cycle proteins in Drosophila. [FBrf0127207]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Bellen, 2011.5.31, set938.xml set938.xml [FBrf0213719] Bellen, 2011.10.25, set956.xml set956.xml [FBrf0216550] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Perkins et al., 2009, Update to TRiP stock collection. Update to TRiP stock collection. [FBrf0208864] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. (Computer file) Genomic mapping of Exelixis insertion collection. (Computer file) [FBrf0184340] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] Gene Disruption Project members, 2001-, (Computer file) (Computer file) [FBrf0132177]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Stock list	Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY. RNAi stocks available from NIG-FLY. [FBrf0218457]